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Conserved domains on  [gi|51092283|ref|NP_001003672|]
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protocadherin alpha-C2 precursor [Mus musculus]

Protein Classification

protocadherin( domain architecture ID 13228241)

protocadherin is a transmembrane protein belonging to the cadherin superfamily and may be a calcium-dependent cell-adhesion protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 856-972 1.15e-68

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


:

Pssm-ID: 435046  Cd Length: 134  Bit Score: 225.28  E-value: 1.15e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283    856 RQPNPDWRYSASLRAG-MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ 934
Cdd:pfam15974    1 KPPNPDWRYSASLRAGpMQSSVHMEEAGVLRGGPGGLEQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFRYGPGNPKQ 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 51092283    935 SGPGELPDKFIIPGSPAIISIRQEPANNQiDKSDFITF 972
Cdd:pfam15974   81 PVPGEYPENFIIPGSPAIISIRQPQAQTQ-DQSDFITF 117
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 260-360 3.59e-36

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 132.05  E-value: 3.59e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283  260 TYRVQLREDAPPGTLVVKLNASDPDEGSNGELRYSLSSytsDRERQLFSIDVTTGEVRVSGTLDYEESSSYQIYVQATDR 339
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS---GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 51092283  340 GPVPMAGHCKVLVDIIDVNDN 360
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 472-574 2.51e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.41  E-value: 2.51e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283  472 SYSIYIEENNLPGVLLCTVQATDPDQKENAEVTYSLLDREIQGlpvtsYVSINSASGSLYAVNSFDYEKFREFFVTVEAQ 551
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 51092283  552 DKGRPPLSSTVTANVYVVDVNDH 574
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_2 super family cl29227
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 42-126 3.88e-26

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


The actual alignment was detected with superfamily member pfam08266:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 102.61  E-value: 3.88e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283     42 QLRYSVPEEQSPGALVGNVARALGLELRRLGPGCLRInhLGAPSPRYLELDLTNGALFVNERIDREALCEQRPRCLLSLE 121
Cdd:pfam08266    1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARV--VSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQ 78


                   ....*
gi 51092283    122 VLAHN 126
Cdd:pfam08266   79 VLLEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 152-252 8.06e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 8.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283  152 YQLQVSESVAPGARFHIESAQDPDVGANSVQTYELS---PSEHFELDlkplqenSKVLELVLRKGLDREQTALHYLVLTA 228
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSID-------PSTGEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....
gi 51092283  229 VDGGIPARSGTAQIAVRVLDTNDN 252
Cdd:cd11304   75 TDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 373-464 3.82e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 3.82e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283  373 VPEDVALNTVVALLSVNDQDSGSNRKVS---LGLEASLPFRLNGfgNSYTLVVSGPLDRERVAAYNITVTATDGGVPPLT 449
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTysiVSGNEDGLFSIDP--STGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 51092283  450 SQRTLQVEISDINDN 464
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 593-681 5.01e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 5.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283  593 VPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLVPTSDSDLFKVELHTGEIRITRKIGDESGTTFNLTVVVRDNGEPPLSAT 672
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                 ....*....
gi 51092283  673 VAITVAVVD 681
Cdd:cd11304   86 ATVTITVLD 94
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 702-809 2.06e-23

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 94.90  E-value: 2.06e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283    702 EITLYLIIALSTVSFIFLLTIIVLSIIKCYrytaygtaccggfcgvRERCPAELYKQANNnidARIPHglkvqPHFIEVR 781
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLIALRLR----------------RWRSSALLQSSGNL---CSVPA-----PHFPGND 56

                           90       100
                   ....*....|....*....|....*...
gi 51092283    782 GNGSLTKTYCYKACLTAGSGSDTFMFYN 809
Cdd:pfam16492   57 GTGTLPQSYSYEVCLTSDSGKSEFKFLK 84
 
Name Accession Description Interval E-value
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 856-972 1.15e-68

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 225.28  E-value: 1.15e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283    856 RQPNPDWRYSASLRAG-MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ 934
Cdd:pfam15974    1 KPPNPDWRYSASLRAGpMQSSVHMEEAGVLRGGPGGLEQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFRYGPGNPKQ 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 51092283    935 SGPGELPDKFIIPGSPAIISIRQEPANNQiDKSDFITF 972
Cdd:pfam15974   81 PVPGEYPENFIIPGSPAIISIRQPQAQTQ-DQSDFITF 117
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 260-360 3.59e-36

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 132.05  E-value: 3.59e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283  260 TYRVQLREDAPPGTLVVKLNASDPDEGSNGELRYSLSSytsDRERQLFSIDVTTGEVRVSGTLDYEESSSYQIYVQATDR 339
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS---GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 51092283  340 GPVPMAGHCKVLVDIIDVNDN 360
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 472-574 2.51e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.41  E-value: 2.51e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283  472 SYSIYIEENNLPGVLLCTVQATDPDQKENAEVTYSLLDREIQGlpvtsYVSINSASGSLYAVNSFDYEKFREFFVTVEAQ 551
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 51092283  552 DKGRPPLSSTVTANVYVVDVNDH 574
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 42-126 3.88e-26

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 102.61  E-value: 3.88e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283     42 QLRYSVPEEQSPGALVGNVARALGLELRRLGPGCLRInhLGAPSPRYLELDLTNGALFVNERIDREALCEQRPRCLLSLE 121
Cdd:pfam08266    1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARV--VSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQ 78


                   ....*
gi 51092283    122 VLAHN 126
Cdd:pfam08266   79 VLLEN 83
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 279-362 1.05e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 101.27  E-value: 1.05e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283     279 NASDPDEGSNGELRYSLSSytsDRERQLFSIDVTTGEVRVSGTLDYEESSSYQIYVQATDRGPVPMAGHCKVLVDIIDVN 358
Cdd:smart00112    1 SATDADSGENGKVTYSILS---GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 51092283     359 DNAP 362
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 152-252 8.06e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 8.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283  152 YQLQVSESVAPGARFHIESAQDPDVGANSVQTYELS---PSEHFELDlkplqenSKVLELVLRKGLDREQTALHYLVLTA 228
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSID-------PSTGEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....
gi 51092283  229 VDGGIPARSGTAQIAVRVLDTNDN 252
Cdd:cd11304   75 TDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 373-464 3.82e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 3.82e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283  373 VPEDVALNTVVALLSVNDQDSGSNRKVS---LGLEASLPFRLNGfgNSYTLVVSGPLDRERVAAYNITVTATDGGVPPLT 449
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTysiVSGNEDGLFSIDP--STGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 51092283  450 SQRTLQVEISDINDN 464
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 593-681 5.01e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 5.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283  593 VPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLVPTSDSDLFKVELHTGEIRITRKIGDESGTTFNLTVVVRDNGEPPLSAT 672
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                 ....*....
gi 51092283  673 VAITVAVVD 681
Cdd:cd11304   86 ATVTITVLD 94
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 702-809 2.06e-23

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 94.90  E-value: 2.06e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283    702 EITLYLIIALSTVSFIFLLTIIVLSIIKCYrytaygtaccggfcgvRERCPAELYKQANNnidARIPHglkvqPHFIEVR 781
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLIALRLR----------------RWRSSALLQSSGNL---CSVPA-----PHFPGND 56

                           90       100
                   ....*....|....*....|....*...
gi 51092283    782 GNGSLTKTYCYKACLTAGSGSDTFMFYN 809
Cdd:pfam16492   57 GTGTLPQSYSYEVCLTSDSGKSEFKFLK 84
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 491-576 5.52e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.87  E-value: 5.52e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283     491 QATDPDQKENAEVTYSLLDREIQGlpvtsYVSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGRPPLSSTVTANVYVVD 570
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDG-----LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                    ....*.
gi 51092283     571 VNDHAP 576
Cdd:smart00112   76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
261-355 2.18e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.28  E-value: 2.18e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283    261 YRVQLREDAPPGTLVVKLNASDPDEGSNGELRYSLSSytsDRERQLFSIDVTTGEVRVSGTLDYEESSSYQIYVQATDRG 340
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILG---GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 51092283    341 PVPMAGHCKVLVDII 355
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 387-466 1.22e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 1.22e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283     387 SVNDQDSGSNRKVS---LGLEASLPFRLNGfgNSYTLVVSGPLDRERVAAYNITVTATDGGVPPLTSQRTLQVEISDIND 463
Cdd:smart00112    1 SATDADSGENGKVTysiLSGNDDGLFSIDP--ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 51092283     464 NPP 466
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 608-681 4.70e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.62  E-value: 4.70e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 51092283     608 AMDSDSGQNAWLFYHLVPTSDSDLFKVELHTGEIRITRKIGDESGTTFNLTVVVRDNGEPPLSATVAITVAVVD 681
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 170-254 6.11e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.23  E-value: 6.11e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283     170 SAQDPDVGANSVQTYELSPSE---HFELDlkplqENSKVLelVLRKGLDREQTALHYLVLTAVDGGIPARSGTAQIAVRV 246
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNddgLFSID-----PETGEI--TTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                    ....*...
gi 51092283     247 LDTNDNSP 254
Cdd:smart00112   74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
473-568 4.61e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 4.61e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283    473 YSIYIEENNLPGVLLCTVQATDPDQKENAEVTYSLLdreiqGLPVTSYVSINSASGSLYAVNSFDYEKFREFFVTVEAQD 552
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL-----GGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*.
gi 51092283    553 KGRPPLSSTVTANVYV 568
Cdd:pfam00028   76 SGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
593-679 7.14e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 7.14e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283    593 VPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLVPTSDSDLFKVELHTGEIRITRKIGDESGTTFNLTVVVRDNGEPPLSAT 672
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                   ....*..
gi 51092283    673 VAITVAV 679
Cdd:pfam00028   85 ATVTITV 91
Cadherin pfam00028
Cadherin domain;
373-458 4.50e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 4.50e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283    373 VPEDVALNTVVALLSVNDQDSGSNRKVS---LGLEASLPFRLNGfgNSYTLVVSGPLDRERVAAYNITVTATDGGVPPLT 449
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFysiLGGGPGGNFRIDP--DTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82


                   ....*....
gi 51092283    450 SQRTLQVEI 458
Cdd:pfam00028   83 STATVTITV 91
Cadherin pfam00028
Cadherin domain;
152-247 4.77e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 4.77e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283    152 YQLQVSESVAPGARFHIESAQDPDVGANSVQTYELS---PSEHFELDLKPLqenskvlELVLRKGLDREQTALHYLVLTA 228
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*....
gi 51092283    229 VDGGIPARSGTAQIAVRVL 247
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 44-143 2.17e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 52.70  E-value: 2.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283   44 RYSVPEEQSPGALVGNVaRALGLELRRLGPGCLRInhLGAPSPRYLELDLTNGALFVNERIDREALCEqrprclLSLEVL 123
Cdd:cd11304    3 EVSVPENAPPGTVVLTV-SATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSS------YTLTVT 73

                         90       100
                 ....*....|....*....|....*
gi 51092283  124 AHNP-----VAVSAIEVEILDINDN 143
Cdd:cd11304   74 ATDGggpplSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 81-145 1.83e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.18  E-value: 1.83e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 51092283      81 LGAPSPRYLELDLTNGALFVNERIDREalceQRPRCLLSLEVLAHNPVAVSA---IEVEILDINDNSP 145
Cdd:smart00112   18 LSGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSStatVTITVLDVNDNAP 81
PHA02867 PHA02867
C-type lectin protein; Provisional
 698-751 7.32e-03

C-type lectin protein; Provisional


Pssm-ID: 165201  Cd Length: 167  Bit Score: 38.51  E-value: 7.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 51092283   698 RTYSEITLYLIIALSTVSFIFLLTIIVLsIIKC-YRYTAYGTACCGGFCGVRERC 751
Cdd:PHA02867    7 KQVSEVSCYAITVLGILCLILFTILVVV-TCKWyYAFPYFSKVCPDEWIGYNSKC 60
 
Name Accession Description Interval E-value
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 856-972 1.15e-68

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 225.28  E-value: 1.15e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283    856 RQPNPDWRYSASLRAG-MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ 934
Cdd:pfam15974    1 KPPNPDWRYSASLRAGpMQSSVHMEEAGVLRGGPGGLEQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFRYGPGNPKQ 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 51092283    935 SGPGELPDKFIIPGSPAIISIRQEPANNQiDKSDFITF 972
Cdd:pfam15974   81 PVPGEYPENFIIPGSPAIISIRQPQAQTQ-DQSDFITF 117
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 260-360 3.59e-36

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 132.05  E-value: 3.59e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283  260 TYRVQLREDAPPGTLVVKLNASDPDEGSNGELRYSLSSytsDRERQLFSIDVTTGEVRVSGTLDYEESSSYQIYVQATDR 339
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS---GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 51092283  340 GPVPMAGHCKVLVDIIDVNDN 360
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 472-574 2.51e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 112.41  E-value: 2.51e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283  472 SYSIYIEENNLPGVLLCTVQATDPDQKENAEVTYSLLDREIQGlpvtsYVSINSASGSLYAVNSFDYEKFREFFVTVEAQ 551
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 51092283  552 DKGRPPLSSTVTANVYVVDVNDH 574
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 42-126 3.88e-26

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 102.61  E-value: 3.88e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283     42 QLRYSVPEEQSPGALVGNVARALGLELRRLGPGCLRInhLGAPSPRYLELDLTNGALFVNERIDREALCEQRPRCLLSLE 121
Cdd:pfam08266    1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARV--VSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQ 78


                   ....*
gi 51092283    122 VLAHN 126
Cdd:pfam08266   79 VLLEN 83
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 279-362 1.05e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 101.27  E-value: 1.05e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283     279 NASDPDEGSNGELRYSLSSytsDRERQLFSIDVTTGEVRVSGTLDYEESSSYQIYVQATDRGPVPMAGHCKVLVDIIDVN 358
Cdd:smart00112    1 SATDADSGENGKVTYSILS---GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 51092283     359 DNAP 362
Cdd:smart00112   78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 152-252 8.06e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 8.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283  152 YQLQVSESVAPGARFHIESAQDPDVGANSVQTYELS---PSEHFELDlkplqenSKVLELVLRKGLDREQTALHYLVLTA 228
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSID-------PSTGEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....
gi 51092283  229 VDGGIPARSGTAQIAVRVLDTNDN 252
Cdd:cd11304   75 TDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 373-464 3.82e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 3.82e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283  373 VPEDVALNTVVALLSVNDQDSGSNRKVS---LGLEASLPFRLNGfgNSYTLVVSGPLDRERVAAYNITVTATDGGVPPLT 449
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTysiVSGNEDGLFSIDP--STGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 51092283  450 SQRTLQVEISDINDN 464
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 593-681 5.01e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 5.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283  593 VPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLVPTSDSDLFKVELHTGEIRITRKIGDESGTTFNLTVVVRDNGEPPLSAT 672
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                 ....*....
gi 51092283  673 VAITVAVVD 681
Cdd:cd11304   86 ATVTITVLD 94
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 702-809 2.06e-23

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 94.90  E-value: 2.06e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283    702 EITLYLIIALSTVSFIFLLTIIVLSIIKCYrytaygtaccggfcgvRERCPAELYKQANNnidARIPHglkvqPHFIEVR 781
Cdd:pfam16492    1 DLTFYLVIALASVSFLFLLFVIVLIALRLR----------------RWRSSALLQSSGNL---CSVPA-----PHFPGND 56

                           90       100
                   ....*....|....*....|....*...
gi 51092283    782 GNGSLTKTYCYKACLTAGSGSDTFMFYN 809
Cdd:pfam16492   57 GTGTLPQSYSYEVCLTSDSGKSEFKFLK 84
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 491-576 5.52e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.87  E-value: 5.52e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283     491 QATDPDQKENAEVTYSLLDREIQGlpvtsYVSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGRPPLSSTVTANVYVVD 570
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDG-----LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                    ....*.
gi 51092283     571 VNDHAP 576
Cdd:smart00112   76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
261-355 2.18e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.28  E-value: 2.18e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283    261 YRVQLREDAPPGTLVVKLNASDPDEGSNGELRYSLSSytsDRERQLFSIDVTTGEVRVSGTLDYEESSSYQIYVQATDRG 340
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILG---GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 51092283    341 PVPMAGHCKVLVDII 355
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 387-466 1.22e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 1.22e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283     387 SVNDQDSGSNRKVS---LGLEASLPFRLNGfgNSYTLVVSGPLDRERVAAYNITVTATDGGVPPLTSQRTLQVEISDIND 463
Cdd:smart00112    1 SATDADSGENGKVTysiLSGNDDGLFSIDP--ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 51092283     464 NPP 466
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 608-681 4.70e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.62  E-value: 4.70e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 51092283     608 AMDSDSGQNAWLFYHLVPTSDSDLFKVELHTGEIRITRKIGDESGTTFNLTVVVRDNGEPPLSATVAITVAVVD 681
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 170-254 6.11e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.23  E-value: 6.11e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283     170 SAQDPDVGANSVQTYELSPSE---HFELDlkplqENSKVLelVLRKGLDREQTALHYLVLTAVDGGIPARSGTAQIAVRV 246
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNddgLFSID-----PETGEI--TTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                    ....*...
gi 51092283     247 LDTNDNSP 254
Cdd:smart00112   74 LDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
473-568 4.61e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 4.61e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283    473 YSIYIEENNLPGVLLCTVQATDPDQKENAEVTYSLLdreiqGLPVTSYVSINSASGSLYAVNSFDYEKFREFFVTVEAQD 552
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL-----GGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*.
gi 51092283    553 KGRPPLSSTVTANVYV 568
Cdd:pfam00028   76 SGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
593-679 7.14e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 7.14e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283    593 VPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLVPTSDSDLFKVELHTGEIRITRKIGDESGTTFNLTVVVRDNGEPPLSAT 672
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                   ....*..
gi 51092283    673 VAITVAV 679
Cdd:pfam00028   85 ATVTITV 91
Cadherin pfam00028
Cadherin domain;
373-458 4.50e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 4.50e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283    373 VPEDVALNTVVALLSVNDQDSGSNRKVS---LGLEASLPFRLNGfgNSYTLVVSGPLDRERVAAYNITVTATDGGVPPLT 449
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFysiLGGGPGGNFRIDP--DTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82


                   ....*....
gi 51092283    450 SQRTLQVEI 458
Cdd:pfam00028   83 STATVTITV 91
Cadherin pfam00028
Cadherin domain;
152-247 4.77e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.70  E-value: 4.77e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283    152 YQLQVSESVAPGARFHIESAQDPDVGANSVQTYELS---PSEHFELDLKPLqenskvlELVLRKGLDREQTALHYLVLTA 228
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*....
gi 51092283    229 VDGGIPARSGTAQIAVRVL 247
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 44-143 2.17e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 52.70  E-value: 2.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283   44 RYSVPEEQSPGALVGNVaRALGLELRRLGPGCLRInhLGAPSPRYLELDLTNGALFVNERIDREALCEqrprclLSLEVL 123
Cdd:cd11304    3 EVSVPENAPPGTVVLTV-SATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSS------YTLTVT 73

                         90       100
                 ....*....|....*....|....*
gi 51092283  124 AHNP-----VAVSAIEVEILDINDN 143
Cdd:cd11304   74 ATDGggpplSSTATVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 45-143 6.78e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 42.72  E-value: 6.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51092283   45 YSVPEEQSPGALVGNVARALGLELRRLgpgcLRINHLGAPS-PRYLELDLTNGALFVNERIDREALceqrprCLLSLEVL 123
Cdd:cd00031    4 GSAVEGRSRGSFRVSIPTDLIASSGEI----IKISAAGKEAlPSWLHWEPHSGILEGLEKLDREDK------GVHYISVS 73

                         90       100
                 ....*....|....*....|....*
gi 51092283  124 A-----HNPVAVSAIEVEILDINDN 143
Cdd:cd00031   74 AaslgaNVPQTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 81-145 1.83e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.18  E-value: 1.83e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 51092283      81 LGAPSPRYLELDLTNGALFVNERIDREalceQRPRCLLSLEVLAHNPVAVSA---IEVEILDINDNSP 145
Cdd:smart00112   18 LSGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSStatVTITVLDVNDNAP 81
PHA02867 PHA02867
C-type lectin protein; Provisional
 698-751 7.32e-03

C-type lectin protein; Provisional


Pssm-ID: 165201  Cd Length: 167  Bit Score: 38.51  E-value: 7.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 51092283   698 RTYSEITLYLIIALSTVSFIFLLTIIVLsIIKC-YRYTAYGTACCGGFCGVRERC 751
Cdd:PHA02867    7 KQVSEVSCYAITVLGILCLILFTILVVV-TCKWyYAFPYFSKVCPDEWIGYNSKC 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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