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Conserved domains on  [gi|348041327|ref|NP_001003583|]
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opticin precursor [Danio rerio]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12020562)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
134-273 4.12e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 4.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 134 DLTHIPPLPKET--THFYARFNKITEIkAADFINLNQLKRIDLSGNQIGKVNEdAFRSLLQLQDLMMADNNIQALPE--- 208
Cdd:COG4886  102 DLSGNEELSNLTnlESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEelg 179

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 348041327 209 -LPaSLKHIDIRNNKLRSSGmhaEAFKEMKELQFLYLSHNKLDYIPVPLPE--SLRVLHLQNNNIQSI 273
Cdd:COG4886  180 nLT-NLKELDLSNNQITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL 243
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 121-142 2.19e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 34.91  E-value: 2.19e-03
                          10        20
                  ....*....|....*....|...
gi 348041327  121 CVCISGSVYCDDSDLTHIPP-LP 142
Cdd:pfam01462   6 CHCSATVVNCSDRGLTAVPRdLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
134-273 4.12e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 4.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 134 DLTHIPPLPKET--THFYARFNKITEIkAADFINLNQLKRIDLSGNQIGKVNEdAFRSLLQLQDLMMADNNIQALPE--- 208
Cdd:COG4886  102 DLSGNEELSNLTnlESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEelg 179

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 348041327 209 -LPaSLKHIDIRNNKLRSSGmhaEAFKEMKELQFLYLSHNKLDYIPVPLPE--SLRVLHLQNNNIQSI 273
Cdd:COG4886  180 nLT-NLKELDLSNNQITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL 243
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 120-301 3.56e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.95  E-value: 3.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 120 LCVCISGSV-YCDDSDLTHIPPLPKET--THFYARFNKITEIKaaDFINLNQLKRIDLSGNQIGKVNedAFRSLLQLQDL 196
Cdd:cd21340   20 LSLCKNLKVlYLYDNKITKIENLEFLTnlTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVE--GLENLTNLEEL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 197 MMADnniQALPE-------------LPASLKHIDIRNNKLRSsgmhaeafkeMKELQFLYlshnkldyipvplpeSLRVL 263
Cdd:cd21340   96 HIEN---QRLPPgekltfdprslaaLSNSLRVLNISGNNIDS----------LEPLAPLR---------------NLEQL 147

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 348041327 264 HLQNNNIQSITQDTFCNSHDKNyirkaLEDIRLDGNPV 301
Cdd:cd21340  148 DASNNQISDLEELLDLLSSWPS-----LRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
168-249 5.13e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 5.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327  168 QLKRIDLSGNQIGKVNEDAFRSLlqlqdlmmadnniqalpelpASLKHIDIRNNKLRSsgMHAEAFKEMKELQFLYLSHN 247
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGL--------------------SNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGN 59


                  ..
gi 348041327  248 KL 249
Cdd:pfam13855  60 RL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
192-273 9.88e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.47  E-value: 9.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 192 QLQDLMMADNNIQALPE-LPASLKHIDIRNNKL-RSSGMHAEAFKEMK---------------ELQFLYLSHNKLDYIPV 254
Cdd:PRK15370 200 QITTLILDNNELKSLPEnLQGNIKTLYANSNQLtSIPATLPDTIQEMElsinritelperlpsALQSLDLFHNKISCLPE 279

                         90
                 ....*....|....*....
gi 348041327 255 PLPESLRVLHLQNNNIQSI 273
Cdd:PRK15370 280 NLPEELRYLSVYDNSIRTL 298
LRRNT smart00013
Leucine rich repeat N-terminal domain;
121-147 1.70e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.45  E-value: 1.70e-04
                           10        20
                   ....*....|....*....|....*...
gi 348041327   121 CVCISGSVYCDDSDLTHIPP-LPKETTH 147
Cdd:smart00013   6 CNCSGTAVDCSGRGLTEVPLdLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 121-142 2.19e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 34.91  E-value: 2.19e-03
                          10        20
                  ....*....|....*....|...
gi 348041327  121 CVCISGSVYCDDSDLTHIPP-LP 142
Cdd:pfam01462   6 CHCSATVVNCSDRGLTAVPRdLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
134-273 4.12e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 4.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 134 DLTHIPPLPKET--THFYARFNKITEIkAADFINLNQLKRIDLSGNQIGKVNEdAFRSLLQLQDLMMADNNIQALPE--- 208
Cdd:COG4886  102 DLSGNEELSNLTnlESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEelg 179

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 348041327 209 -LPaSLKHIDIRNNKLRSSGmhaEAFKEMKELQFLYLSHNKLDYIPVPLPE--SLRVLHLQNNNIQSI 273
Cdd:COG4886  180 nLT-NLKELDLSNNQITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL 243
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
127-301 1.69e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 1.69e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 127 SVYCDDSDLTHIPP-LPKET--THFYARFNKITEIKAAdFINLNQLKRIDLSGNQIGKVNEdAFRSLLQLQDLMMADNNI 203
Cdd:COG4886  117 SLDLSGNQLTDLPEeLANLTnlKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQI 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 204 QALPE----LPaSLKHIDIRNNKLRSSGmhaEAFKEMKELQFLYLSHNKLDYIPV--PLPeSLRVLHLQNNNIQSITQDT 277
Cdd:COG4886  195 TDLPEplgnLT-NLEELDLSGNQLTDLP---EPLANLTNLETLDLSNNQLTDLPElgNLT-NLEELDLSNNQLTDLPPLA 269

                        170       180
                 ....*....|....*....|....
gi 348041327 278 FCnshdknyirKALEDIRLDGNPV 301
Cdd:COG4886  270 NL---------TNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
127-308 4.80e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 4.80e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 127 SVYCDDSDLTHIP----PLPKeTTHFYARFNKITEIKAAdFINLNQLKRIDLSGNQIGKVNEDaFRSLLQLQDLMMADNN 202
Cdd:COG4886  163 SLDLSNNQLTDLPeelgNLTN-LKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQ 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 203 IQALPELPA--SLKHIDIRNNKLRSsgmhAEAFKEMKELQFLYLSHNKLDYIPVPLPESLRVLHLQNNNIQSITQDTFCN 280
Cdd:COG4886  240 LTDLPELGNltNLEELDLSNNQLTD----LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315

                        170       180
                 ....*....|....*....|....*...
gi 348041327 281 SHDKNYIRKALEDIRLDGNPVDINLYPQ 308
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVTLTTLALS 343
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 120-301 3.56e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.95  E-value: 3.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 120 LCVCISGSV-YCDDSDLTHIPPLPKET--THFYARFNKITEIKaaDFINLNQLKRIDLSGNQIGKVNedAFRSLLQLQDL 196
Cdd:cd21340   20 LSLCKNLKVlYLYDNKITKIENLEFLTnlTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVE--GLENLTNLEEL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 197 MMADnniQALPE-------------LPASLKHIDIRNNKLRSsgmhaeafkeMKELQFLYlshnkldyipvplpeSLRVL 263
Cdd:cd21340   96 HIEN---QRLPPgekltfdprslaaLSNSLRVLNISGNNIDS----------LEPLAPLR---------------NLEQL 147

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 348041327 264 HLQNNNIQSITQDTFCNSHDKNyirkaLEDIRLDGNPV 301
Cdd:cd21340  148 DASNNQISDLEELLDLLSSWPS-----LRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
168-249 5.13e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 5.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327  168 QLKRIDLSGNQIGKVNEDAFRSLlqlqdlmmadnniqalpelpASLKHIDIRNNKLRSsgMHAEAFKEMKELQFLYLSHN 247
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGL--------------------SNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGN 59


                  ..
gi 348041327  248 KL 249
Cdd:pfam13855  60 RL 61
LRR_8 pfam13855
Leucine rich repeat;
212-270 4.87e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 4.87e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 348041327  212 SLKHIDIRNNKLRSsgMHAEAFKEMKELQFLYLSHNKLDYIP----VPLPeSLRVLHLQNNNI 270
Cdd:pfam13855   2 NLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSpgafSGLP-SLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
192-273 9.88e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.47  E-value: 9.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 192 QLQDLMMADNNIQALPE-LPASLKHIDIRNNKL-RSSGMHAEAFKEMK---------------ELQFLYLSHNKLDYIPV 254
Cdd:PRK15370 200 QITTLILDNNELKSLPEnLQGNIKTLYANSNQLtSIPATLPDTIQEMElsinritelperlpsALQSLDLFHNKISCLPE 279

                         90
                 ....*....|....*....
gi 348041327 255 PLPESLRVLHLQNNNIQSI 273
Cdd:PRK15370 280 NLPEELRYLSVYDNSIRTL 298
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
127-270 1.95e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.31  E-value: 1.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 127 SVYCDDSDLTHIPP-LPKETTHFYARFNKITEIKAadfiNL-NQLKRIDLSGNQIGKVNEDAFRsllQLQDLMMADNNIQ 204
Cdd:PRK15370 224 TLYANSNQLTSIPAtLPDTIQEMELSINRITELPE----RLpSALQSLDLFHNKISCLPENLPE---ELRYLSVYDNSIR 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 205 ALPE-LPASLKHIDIRNNKLRS-------------------SGMHAEAFKEMKEL------------------QFLYLSH 246
Cdd:PRK15370 297 TLPAhLPSGITHLNVQSNSLTAlpetlppglktleagenalTSLPASLPPELQVLdvsknqitvlpetlpptiTTLDVSR 376

                        170       180
                 ....*....|....*....|....
gi 348041327 247 NKLDYIPVPLPESLRVLHLQNNNI 270
Cdd:PRK15370 377 NALTNLPENLPAALQIMQASRNNL 400
LRR_8 pfam13855
Leucine rich repeat;
151-203 2.09e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 2.09e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 348041327  151 RFNKITEIKAADFINLNQLKRIDLSGNQIGKVNEDAFRSLLQLQDLMMADNNI 203
Cdd:pfam13855   9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
135-273 3.70e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 48.62  E-value: 3.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 135 LTHIPPLPKETTHFYARFNKIT----------EIKAADfinlNQLKRIDLSGNQIGKV--NEDAFRSLLQL----QDLMM 198
Cdd:PRK15387 274 LTHLPALPSGLCKLWIFGNQLTslpvlppglqELSVSD----NQLASLPALPSELCKLwaYNNQLTSLPTLpsglQELSV 349

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 348041327 199 ADNNIQALPELPASLKHIDIRNNKLRSSGMHAEAFKEmkelqfLYLSHNKLDYIPVpLPESLRVLHLQNNNIQSI 273
Cdd:PRK15387 350 SDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKE------LIVSGNRLTSLPV-LPSELKELMVSGNRLTSL 417
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 162-268 6.28e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 6.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 162 DFINLNQLKRIDLSGNQIGKVNEDAFRSLLQLQDLMMADNNIQA-LPELPASLKH---IDIRNNKLrsSGMHAEAFKEMK 237
Cdd:PLN00113 470 DSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKlvsLDLSHNQL--SGQIPASFSEMP 547

                         90       100       110
                 ....*....|....*....|....*....|....
gi 348041327 238 ELQFLYLSHNKLD-YIPVPLP--ESLRVLHLQNN 268
Cdd:PLN00113 548 VLSQLDLSQNQLSgEIPKNLGnvESLVQVNISHN 581
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 168-249 1.60e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.81  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 168 QLKRIDLSGNQIGKVN----EDAFRSLLQLQDLMMADNNI---------QALPELPASLKHIDIRNNKLRSSG--MHAEA 232
Cdd:cd00116  194 NLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLtdagaaalaSALLSPNISLLTLSLSCNDITDDGakDLAEV 273

                         90
                 ....*....|....*..
gi 348041327 233 FKEMKELQFLYLSHNKL 249
Cdd:cd00116  274 LAEKESLLELDLRGNKF 290
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
135-273 3.58e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.46  E-value: 3.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 135 LTHIPP-LPKETTHFYARFNKITEIKAadfiNLN-QLKRIDLSGNQIGKVNEdAFRSLLQLQDLMMadNNIQALPE-LPA 211
Cdd:PRK15370 190 LTTIPAcIPEQITTLILDNNELKSLPE----NLQgNIKTLYANSNQLTSIPA-TLPDTIQEMELSI--NRITELPErLPS 262

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 348041327 212 SLKHIDIRNNKLRSSgmhAEAFKEmkELQFLYLSHNKLDYIPVPLPESLRVLHLQNNNIQSI 273
Cdd:PRK15370 263 ALQSLDLFHNKISCL---PENLPE--ELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTAL 319
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 163-302 7.87e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 7.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 163 FINLNQLKRIDLSGNQIGKVNEDAFRSLLQ---LQDLMMADNNI---------QALPELPASLKHIDIRNNKLRSSGMH- 229
Cdd:cd00116   77 LTKGCGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLgdrglrllaKGLKDLPPALEKLVLGRNRLEGASCEa 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 230 -AEAFKEMKELQFLYLSHNKLD-----YIPVPLPES--LRVLHLQNNNIQSITQDTFCNSHDKNyirKALEDIRLDGNPV 301
Cdd:cd00116  157 lAKALRANRDLKELNLANNGIGdagirALAEGLKANcnLEVLDLNNNGLTDEGASALAETLASL---KSLEVLNLGDNNL 233


                 .
gi 348041327 302 D 302
Cdd:cd00116  234 T 234
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 167-270 8.31e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.01  E-value: 8.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 167 NQLKRIDLSGNQIG----KVNEDAFRSLLQLQDLMMADNNI---------QALPELPaSLKHIDIRNNKLRSSGMH--AE 231
Cdd:COG5238  180 NSVETVYLGCNQIGdegiEELAEALTQNTTVTTLWLKRNPIgdegaeilaEALKGNK-SLTTLDLSNNQIGDEGVIalAE 258

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 348041327 232 AFKEMKELQFLYLSHNKLD-----YIPVPL--PESLRVLHLQNNNI 270
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGaegaiALAKALqgNTTLTSLDLSVNRI 304
LRRNT smart00013
Leucine rich repeat N-terminal domain;
121-147 1.70e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.45  E-value: 1.70e-04
                           10        20
                   ....*....|....*....|....*...
gi 348041327   121 CVCISGSVYCDDSDLTHIPP-LPKETTH 147
Cdd:smart00013   6 CNCSGTAVDCSGRGLTEVPLdLPPDTTL 33
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
124-273 2.09e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 2.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 124 ISGSVYCDDSDLTHIPPLPKETTHFYARFNKITEIKAADFINLNQLKRIDLSGNQIGKVNEDAFRSLLQLQDLMMADNNI 203
Cdd:COG4886   10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 348041327 204 QALPELpASLKHIDIRNNklrssgmhaEAFKEMKELQFLYLSHNKLDYIPVPLPE--SLRVLHLQNNNIQSI 273
Cdd:COG4886   90 TDLGDL-TNLTELDLSGN---------EELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDL 151
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 160-270 1.47e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 160 AADFINLNQLKRIDLSGNQIGkvnEDAFRSLLQ------------LQDLMMADNNIQALPELPASLK---HIDIRNNKLR 224
Cdd:cd00116  158 AKALRANRDLKELNLANNGIG---DAGIRALAEglkancnlevldLNNNGLTDEGASALAETLASLKsleVLNLGDNNLT 234

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 348041327 225 SSGMHAEAfkemkeLQFLYLSHnkldyipvplpeSLRVLHLQNNNI 270
Cdd:cd00116  235 DAGAAALA------SALLSPNI------------SLLTLSLSCNDI 262
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
175-273 1.81e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.15  E-value: 1.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 175 SGNQIGKVNEDAFRSL-----LQLQDLMMADNNIQALPELPASLKHIDIRNNKLRSSGMHAEAFKEM------------- 236
Cdd:PRK15387 201 NGNAVLNVGESGLTTLpdclpAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELsifsnplthlpal 280

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 348041327 237 -KELQFLYLSHNKLDYIPVpLPESLRVLHLQNNNIQSI 273
Cdd:PRK15387 281 pSGLCKLWIFGNQLTSLPV-LPPGLQELSVSDNQLASL 317
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 121-142 2.19e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 34.91  E-value: 2.19e-03
                          10        20
                  ....*....|....*....|...
gi 348041327  121 CVCISGSVYCDDSDLTHIPP-LP 142
Cdd:pfam01462   6 CHCSATVVNCSDRGLTAVPRdLP 28
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
127-269 3.06e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.15  E-value: 3.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 127 SVYCDDSDLTHIPPLPKET--THFYARFNKITEIKaaDFINLNQLKRIDLSGNQIGKVNEDAFRSLLQLQDLMMADNNIQ 204
Cdd:COG4886  232 TLDLSNNQLTDLPELGNLTnlEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 348041327 205 ALPELPASLKHIDIRNNKLRSSGMHAEAFKEMKELQFLYLSHNKLDYIPVPLPESLRVLHLQNNN 269
Cdd:COG4886  310 LLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 168-270 4.08e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 38.62  E-value: 4.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 348041327 168 QLKRIDLSGNQIGKVNEDAFRSLLQ----LQDLMMADNNI-----QALPEL---PASLKHIDIRNNKLRSSGMH--AEAF 233
Cdd:COG5238  265 TVETLYLSGNQIGAEGAIALAKALQgnttLTSLDLSVNRIgdegaIALAEGlqgNKTLHTLNLAYNGIGAQGAIalAKAL 344

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 348041327 234 KEMKELQFLYLSHNKLD---------YIpvPLPESLRVLHLQNNNI 270
Cdd:COG5238  345 QENTTLHSLDLSDNQIGdegaialakYL--EGNTTLRELNLGKNNI 388
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 242-289 8.06e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.07  E-value: 8.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 348041327 242 LYLSHNKLDYIPV-PLPESLRVLHLQNNNIQSItQDTFCNSH------DKNYIRK 289
Cdd:cd21340    7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKI-ENLEFLTNlthlylQNNQIEK 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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