|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NLS1_MFSD2A |
cd17451 |
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ... |
40-493 |
0e+00 |
|
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341009 Cd Length: 419 Bit Score: 739.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 40 KLCYAIGGAPYQITGCAIGFFLQIYLLDVALLDPFYASIILFVGRAWDAVTDPTVGFLVSRTPWTRFGRMMPWIVLSTPF 119
Cdd:cd17451 1 KLCYAIGGAPYQITGCALGFFLQIYLLDVAQLDPFYASIILFVGRAWDAITDPTVGFFVSKSPWTRFGRLMPWIIFSTPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 120 AVLCYFLIWYVPSVDQGKVVWYLIFYCCFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTLIGTAIQGQIV 199
Cdd:cd17451 81 AVLSYFLIWFVPDFSQGKVMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTVLGTAIQGQIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 200 GMAnapcisteidlnstglevapdvnitdphvslqdlrnAYMIASGVICAIYVVCAVVLFLGVKEQKDTCRVRT-EPMSF 278
Cdd:cd17451 161 GMA------------------------------------AYMIAAGVICAIYVLCAIILFLGVREQREPCELKSqKPVSF 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 279 FQGICMVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCIYNLGFRNDFQNVLLVIMLSATLAIPFWQWFLTKFGKKTAVY 358
Cdd:cd17451 205 FKGLKLVMSHGPYIKLITGFLFTSLAFMLLEGNFALFCTYTLGFRNDFQNILLVIMLSATLTIPFWQWFLTRFGKKTAVY 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 359 IGTTSVVPFLISVVLVPSSLAVTYIASFAAGVSVAAAFLLPWSMLPDVVDDFKVQNPESQGHEAIFYSFYVFFTKFASGV 438
Cdd:cd17451 285 IGISSAVPFLILVVLVESNLIVTYVVSVAAGVSVAAAFLLPWSMLPDVVDDFKLKNPDSQGHEAIFYSFYVFFTKFASGV 364
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 57525841 439 SLGVSTLSLDFAGYVTRGCTQPGEVKLTLKILVSAAPIVLIIIGLLIFISYPINE 493
Cdd:cd17451 365 SLGISTLSLDFAGYQTRGCSQPEEVNLTLKMLVSAAPVVLILLGLLLFKLYPIDE 419
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
42-493 |
1.23e-96 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 299.61 E-value: 1.23e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 42 CYAIGGAPYQITGCAIGFFLQIYLLDVALLDPFYASIILFVGRAWDAVTDPTVGFLVSRTPwTRFGRMMPWIVLSTPFAV 121
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTR-TRWGRRRPWLLLSAIILA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 122 LCYFLIWYVPSVDQ-GKVVWYLIFYCCFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTLIGTAIQGQIVG 200
Cdd:pfam13347 80 VSFILLFTPPELGRaPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 201 MANAPcisteidlnstglevapdvnitdphvslQDLRNAYMIASGVICAIYVVCAVVLFLGVKE----QKDTCRVRTEPM 276
Cdd:pfam13347 160 ILGGT----------------------------GLERKGYRIFALIGAVLMLLGVIITAAGTKErvsmRSKEDTGQKEAG 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 277 SFFQGICMVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCIYNLGFRNDFQNVLLVIMLSATLAIPFWQWFLTKFGKKTA 356
Cdd:pfam13347 212 SLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNT 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 357 VYIGTTSVVP-FLISVVLVPSSLAVTYIASFAAGVSVAAAFLLPWSMLPDVVDDFKVQNPESqgHEAIFYSFYVFFTKFA 435
Cdd:pfam13347 292 YILGALITIAgFALALLLGPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGELRTGKR--REGTFFAMWSFISKLA 369
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 57525841 436 SGVSLGVSTLSLDFAGYVTRGCTQPGEVKLTLKILVSAAPIVLIIIGLLIFISYPINE 493
Cdd:pfam13347 370 TGVGLGVSGLLLSAFGYNAGDSVQSPQAVTAIRLLYAVLPAVLFLVALLLLYFYPLDR 427
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
30-509 |
5.48e-82 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 262.15 E-value: 5.48e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 30 ETKSRLSVCSKLCYAIGGAPYQITGCAIGFFLQIYLLDVALLDPFYASIILFVGRAWDAVTDPTVGFLVSRTpWTRFGRM 109
Cdd:COG2211 2 AAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRT-RTRWGRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 110 MPWIVLSTPFAVLCYFLIWYVPSVDQ-GKVVWYLIFYCCFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGT 188
Cdd:COG2211 81 RPWILIGAIPLALSFVLLFTAPDLSPtGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 189 LIGTAIQGQIVGMANApcisteidlnstglevapdvnitdphvslqDLRNAYMIASGVICAIYVVCAVVLFLGVKEQKdt 268
Cdd:COG2211 161 LLASVLPPPLVAAFGG------------------------------DAALGYRLTALIFAVLGLLAFLLTFFGTKERP-- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 269 cRVRTEPMSFFQGICMVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCIYNLGF-RNDFQNVLLVIMLSATLAIPFWQWF 347
Cdd:COG2211 209 -VPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLsAALVGLLLALYFLAALLGAPLWPRL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 348 LTKFGKKTAVYIGTT-SVVPFLISVVLVPSSLAVTYIASFAAGVSVAAAFLLPWSMLPDVVDDFKVQNPESQghEAIFYS 426
Cdd:COG2211 288 AKRFGKKKAFIIGLLlAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRR--EGLYFG 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 427 FYVFFTKFASGVSLGVSTLSLDFAGYVTrGCTQPGEVKLTLKILVSAAPIVLIIIGLLIFISYPINEEKRQGNRKLLNEQ 506
Cdd:COG2211 366 IFTFAIKLGQALAGALAGLLLALFGYVA-GAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAAR 444
|
...
gi 57525841 507 REN 509
Cdd:COG2211 445 RAA 447
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
40-475 |
8.75e-39 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 147.01 E-value: 8.75e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 40 KLCYAIGGAPYQITGCAIGFFLQIYLLDVALLDPFYASIILFVGRAWDAVTDPTVGFLVSRTPwTRFGRMMPWIVL-STP 118
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTR-TRWGKFRPWLLIgAIP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 119 FAVLCYFLIWYVPSVDQGKVVWYLIFYCCFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMtvevlgtlIGTAIQGQI 198
Cdd:TIGR00792 80 FSIVLVLLFTTPDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRR--------FGATLGGLL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 199 VGMANAPCISteidlnstglevapdvnitdpHVSLQDLRNAYMIASGVICAIYVVCAVVLFLGVKEQKDTCRVRTEP-MS 277
Cdd:TIGR00792 152 VAVIVLPLVS---------------------YFGGGDDKFGWFMFALVLALIGVVSLIICFFGTKERYSEIPKNIEKkLS 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 278 FFQGICMVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCIYNLGFRNDFQNVLLVIMLSATLAIPFWQWFLTKFGKKTAV 357
Cdd:TIGR00792 211 LKQIFKALFKNDQLLILCLAYLFYNLAFNIKNGVQVYYFTYVLGDPELFSYMGSIAIVAGLIGVLLFPRLVKKFGRKILF 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 358 YIGttSVVPFLISVVL--VPSSLAVTYIASFAAGVSVAAAFLLPWSMLPDVVDDFKVQNpesqGH--EAIFYSFYVFFTK 433
Cdd:TIGR00792 291 AGG--ILLMVLGYLIFffAGSNLPLILVLIILAGFGQNIVTGLVWALVADTVDYGEWKT----GIraEGLVYSVRTFVRK 364
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 57525841 434 FASGVSLGVSTLSLDFAGYVTrGCTQPGEVKLTLKILVSAAP 475
Cdd:TIGR00792 365 LGQALAGFFVGLILGIIGYVA-NAAQSPITLNGIKILMFAVP 405
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
33-495 |
8.08e-22 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 97.87 E-value: 8.08e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 33 SRLSVCSKLCYAIGGAPYQITGCAIGFFLQIYLLDVALLDPFYASIILFVGRAWDAVTDPTVGFLVSRTPwTRFGRMMPW 112
Cdd:PRK09669 4 SQLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTR-TRHGQFRPY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 113 IV-LSTPFAVLCyFLIWYVPSV-DQGKVVWYLIFYCCFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTLI 190
Cdd:PRK09669 83 LLwFAIPFGVVC-LLTFYTPDFgATGKIIYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGLI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 191 gtaiqgqiVGMANAPCISteidlnstglevapdvnitdpHVSLQDLRNAYMIASGVICAIYVVCAVVLFLGVKEQkdtCR 270
Cdd:PRK09669 162 --------VSVIALPLVD---------------------ILGKGDEQKGYFYAMMVMGLLGVVLFFCCFFMTKER---YT 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 271 VRTEPM-SFFQGICMVMGHGPYaKLVMGFLFTSLAFMLLEGNFALFCIYNLGFRNDFQNVLLVI-MLSATLAIPFWQWFL 348
Cdd:PRK09669 210 PEVDNSsSVWKDLKLLLGNSQW-RIMFIFNVVLLTAVVTRGGATLYYVNYVLLRPDLATLFLVTgMIAGLFGALLSERLL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 349 TKFGKKTAVYIGTTSVVPFLISVVLVP-SSLAVTYIASFAAGVSVAAAFLLPWSMLPDVVDdfkVQNPES-QGHEAIFYS 426
Cdd:PRK09669 289 GKFDRVRAFKWTIVAFVILSALIFFIPpSNVWLIFALNILFNFIQNLTTPLQWSMFSDVVD---YEEKRSgRRLDGLVFS 365
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 57525841 427 FYVFFTKFasGVSLG--VSTLSLDFAGYVTRGCTQPGEVKLTLKILVSAAPIVLIIIGLLIFISYPINEEK 495
Cdd:PRK09669 366 TNLFAIKL--GLAIGgaVVGWILAWVDYVGGAAVQSASVLTTINLLFTVIPGVLFAGMAIILNFYKLNDAR 434
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NLS1_MFSD2A |
cd17451 |
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ... |
40-493 |
0e+00 |
|
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341009 Cd Length: 419 Bit Score: 739.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 40 KLCYAIGGAPYQITGCAIGFFLQIYLLDVALLDPFYASIILFVGRAWDAVTDPTVGFLVSRTPWTRFGRMMPWIVLSTPF 119
Cdd:cd17451 1 KLCYAIGGAPYQITGCALGFFLQIYLLDVAQLDPFYASIILFVGRAWDAITDPTVGFFVSKSPWTRFGRLMPWIIFSTPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 120 AVLCYFLIWYVPSVDQGKVVWYLIFYCCFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTLIGTAIQGQIV 199
Cdd:cd17451 81 AVLSYFLIWFVPDFSQGKVMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTVLGTAIQGQIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 200 GMAnapcisteidlnstglevapdvnitdphvslqdlrnAYMIASGVICAIYVVCAVVLFLGVKEQKDTCRVRT-EPMSF 278
Cdd:cd17451 161 GMA------------------------------------AYMIAAGVICAIYVLCAIILFLGVREQREPCELKSqKPVSF 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 279 FQGICMVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCIYNLGFRNDFQNVLLVIMLSATLAIPFWQWFLTKFGKKTAVY 358
Cdd:cd17451 205 FKGLKLVMSHGPYIKLITGFLFTSLAFMLLEGNFALFCTYTLGFRNDFQNILLVIMLSATLTIPFWQWFLTRFGKKTAVY 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 359 IGTTSVVPFLISVVLVPSSLAVTYIASFAAGVSVAAAFLLPWSMLPDVVDDFKVQNPESQGHEAIFYSFYVFFTKFASGV 438
Cdd:cd17451 285 IGISSAVPFLILVVLVESNLIVTYVVSVAAGVSVAAAFLLPWSMLPDVVDDFKLKNPDSQGHEAIFYSFYVFFTKFASGV 364
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 57525841 439 SLGVSTLSLDFAGYVTRGCTQPGEVKLTLKILVSAAPIVLIIIGLLIFISYPINE 493
Cdd:cd17451 365 SLGISTLSLDFAGYQTRGCSQPEEVNLTLKMLVSAAPVVLILLGLLLFKLYPIDE 419
|
|
| MFS_MFSD2 |
cd17392 |
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ... |
40-493 |
0e+00 |
|
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340950 Cd Length: 446 Bit Score: 612.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 40 KLCYAIGGAPYQITGCAIGFFLQIYLLDVALLDPFYASIILFVGRAWDAVTDPTVGFLVSRTPWTRFGRMMPWIVLSTPF 119
Cdd:cd17392 1 KLCYAIGGAPYQMTSSATGFFLQIFLLDVAQMGAFSVSLILFVGRVWDAVTDPLVGYFISRSQRTGIGRLMPWIVFSTPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 120 AVLCYFLIWYVPSVDQGKVVWYLIFYCCFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTLIGTAIQGQIV 199
Cdd:cd17392 81 IILAYFFLWFLPPFTSLSGLWYLTFYCLFETFMTCFHVPYSALTMFLGGCQRERDSATAYRMTVEVFGTLMGATIQGQIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 200 GMANAPCISteiDLNSTglEVAPDVnitdPHVSLQDLRNAYMIASGVICAIYVVCAVVLFLGVKEQKD-TCRVRTEPMSF 278
Cdd:cd17392 161 GVAHRPRRQ---DCTAT--PGTSDH----PVTVLPNTRRAYLIAALVVVVLYFVCCSILFLGVKEQPDpLSPASGPGLSY 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 279 FQGICMVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCIYNLGFRNDFQNVLLVIMLSATLAIPFWQWFLTKFGKKTAVY 358
Cdd:cd17392 232 LAGLKLVTGHPPYLKLVIGFLFSSLAFQMEQGNFVLFCTHAAGLGDHFQHLVLAILVSATLSIPLWQWVLQRRGKKTTSF 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 359 IGTTSVVPFLISVVLVPSSLAVTYIASFAAGVSVAAAFLLPWSMLPDVVDDFKVQNPESQGHEAIFYSFYVFFTKFASGV 438
Cdd:cd17392 312 IGISAMVPFLILLALVPSNLPVAYVVAVVSGVSLAALFLLPWSMLPDVVDDFQLKNPHCPGLEPIFYSCYVFFTKLGGGL 391
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 57525841 439 SLGVSTLSLDFAGYVTRGCTQPGEVKLTLKILVSAAPIVLIIIGLLIFISYPINE 493
Cdd:cd17392 392 SLGISTLSLHFSGYKAGACKQPEEVVVTLKVLIAPVPICLILAGLVLFYVYPINE 446
|
|
| MFS_MFSD2B |
cd17452 |
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ... |
40-493 |
0e+00 |
|
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341010 Cd Length: 416 Bit Score: 550.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 40 KLCYAIGGAPYQITGCAIGFFLQIYLLDVALLDPFYASIILFVGRAWDAVTDPTVGFLVSRTPWTRFGRMMPWIVLSTPF 119
Cdd:cd17452 1 KLCYAIGGAPNQVAGSATAFFLQIYLLDIAQITPFQASLVLFVGKAWGAATDPVVGFFISKSKWTKIGRLMPWMLGCTPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 120 AVLCYFLIWYVPSVDQGKVVWYLIFYCCFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTLIGTAIQGQIV 199
Cdd:cd17452 81 IVVSYFFLWFVPPFTTGRFLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRMTVEVLGTLVGAAVQGQIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 200 GmanapcisteidlnstglevapdvnitdphvslqdlrNAYMIASGVICAIYVVCAVVLFLGVKEQKDTCRVRTEP-MSF 278
Cdd:cd17452 161 A-------------------------------------SAYMIAAGVIGGLYLLCISVLFLGVKERDDPYAPKSGKaIPF 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 279 FQGICMVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCIYNLGFRNDFQNVLLVIMLSATLAIPFWQWFLTKFGKKTAvY 358
Cdd:cd17452 204 FKGLSLTMRHGPYLKLTASFLFISAAVQLEQSNFVLFCTHAVDLHDHFQNLVLTILVSAVVSIPFWQWFLQRFGKKAA-A 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 359 IGTTSVVPFLISVVLVPSsLAVTYIASFAAGVSVAAAFLLPWSMLPDVVDDFKVQNPESQGHEAIFYSFYVFFTKFASGV 438
Cdd:cd17452 283 CGISWMIPFAIMLVTIPN-LIVAYVVAFVSGLSIAASLLLPWSMLPDVVDDFRLQNPHGKGLETIFYSSYVFFTKLSAGI 361
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 57525841 439 SLGVSTLSLDFAGYVTRGCTQPGEVKLTLKILVSAAPIVLIIIGLLIFISYPINE 493
Cdd:cd17452 362 ALGISTLSLEFAGYETGACKQPESVVLTLKLLIGAAPTCMILIGLCILMFYPITE 416
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
42-493 |
1.23e-96 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 299.61 E-value: 1.23e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 42 CYAIGGAPYQITGCAIGFFLQIYLLDVALLDPFYASIILFVGRAWDAVTDPTVGFLVSRTPwTRFGRMMPWIVLSTPFAV 121
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTR-TRWGRRRPWLLLSAIILA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 122 LCYFLIWYVPSVDQ-GKVVWYLIFYCCFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTLIGTAIQGQIVG 200
Cdd:pfam13347 80 VSFILLFTPPELGRaPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 201 MANAPcisteidlnstglevapdvnitdphvslQDLRNAYMIASGVICAIYVVCAVVLFLGVKE----QKDTCRVRTEPM 276
Cdd:pfam13347 160 ILGGT----------------------------GLERKGYRIFALIGAVLMLLGVIITAAGTKErvsmRSKEDTGQKEAG 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 277 SFFQGICMVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCIYNLGFRNDFQNVLLVIMLSATLAIPFWQWFLTKFGKKTA 356
Cdd:pfam13347 212 SLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNT 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 357 VYIGTTSVVP-FLISVVLVPSSLAVTYIASFAAGVSVAAAFLLPWSMLPDVVDDFKVQNPESqgHEAIFYSFYVFFTKFA 435
Cdd:pfam13347 292 YILGALITIAgFALALLLGPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGELRTGKR--REGTFFAMWSFISKLA 369
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 57525841 436 SGVSLGVSTLSLDFAGYVTRGCTQPGEVKLTLKILVSAAPIVLIIIGLLIFISYPINE 493
Cdd:pfam13347 370 TGVGLGVSGLLLSAFGYNAGDSVQSPQAVTAIRLLYAVLPAVLFLVALLLLYFYPLDR 427
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
40-475 |
2.12e-92 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 288.35 E-value: 2.12e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 40 KLCYAIGGAPYQITGCAIGFFLQIYLLDVALLDPFYASIILFVGRAWDAVTDPTVGFLVSRTPwTRFGRMMPWIVLSTPF 119
Cdd:cd17332 1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTR-SRWGRFRPWLLWGAIP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 120 AVLCYFLIWYVP-SVDQGKVVWYLIFYCCFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTLIGTAIQGQI 198
Cdd:cd17332 80 LALLFVLLFTTPdGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 199 VGMANAPCISTeidlnstglevapdvnitdphvslqdlrnAYMIASGVICAIYVVCAVVLFLGVKEQKDTCRVRTEPMSF 278
Cdd:cd17332 160 VAYFGGGNASR-----------------------------GYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 279 FQGICMVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCIYNLGFRNDFQNVLLVIMLSATLAIPFWQWFLTKFGKKTAVY 358
Cdd:cd17332 211 LKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFF 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 359 IGTTSVVPFLISVVLVP-SSLAVTYIASFAAGVSVAAAFLLPWSMLPDVVDDFKVQNPesQGHEAIFYSFYVFFTKFASG 437
Cdd:cd17332 291 IGLLLAILGLLLLFFLPpGNLVLILVLAVLAGIGYGGANLLPWAMLADVIDYGELKTG--KRREGIFYSVMTFFRKLGLA 368
|
410 420 430
....*....|....*....|....*....|....*...
gi 57525841 438 VSLGVSTLSLDFAGYVTRGCTQPGEVKLTLKILVSAAP 475
Cdd:cd17332 369 LAGALVGLILSLAGYVANAAAQSASALNGIRLLIAVLP 406
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
30-509 |
5.48e-82 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 262.15 E-value: 5.48e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 30 ETKSRLSVCSKLCYAIGGAPYQITGCAIGFFLQIYLLDVALLDPFYASIILFVGRAWDAVTDPTVGFLVSRTpWTRFGRM 109
Cdd:COG2211 2 AAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRT-RTRWGRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 110 MPWIVLSTPFAVLCYFLIWYVPSVDQ-GKVVWYLIFYCCFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGT 188
Cdd:COG2211 81 RPWILIGAIPLALSFVLLFTAPDLSPtGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 189 LIGTAIQGQIVGMANApcisteidlnstglevapdvnitdphvslqDLRNAYMIASGVICAIYVVCAVVLFLGVKEQKdt 268
Cdd:COG2211 161 LLASVLPPPLVAAFGG------------------------------DAALGYRLTALIFAVLGLLAFLLTFFGTKERP-- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 269 cRVRTEPMSFFQGICMVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCIYNLGF-RNDFQNVLLVIMLSATLAIPFWQWF 347
Cdd:COG2211 209 -VPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLsAALVGLLLALYFLAALLGAPLWPRL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 348 LTKFGKKTAVYIGTT-SVVPFLISVVLVPSSLAVTYIASFAAGVSVAAAFLLPWSMLPDVVDDFKVQNPESQghEAIFYS 426
Cdd:COG2211 288 AKRFGKKKAFIIGLLlAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRR--EGLYFG 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 427 FYVFFTKFASGVSLGVSTLSLDFAGYVTrGCTQPGEVKLTLKILVSAAPIVLIIIGLLIFISYPINEEKRQGNRKLLNEQ 506
Cdd:COG2211 366 IFTFAIKLGQALAGALAGLLLALFGYVA-GAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAAR 444
|
...
gi 57525841 507 REN 509
Cdd:COG2211 445 RAA 447
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
40-475 |
8.75e-39 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 147.01 E-value: 8.75e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 40 KLCYAIGGAPYQITGCAIGFFLQIYLLDVALLDPFYASIILFVGRAWDAVTDPTVGFLVSRTPwTRFGRMMPWIVL-STP 118
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTR-TRWGKFRPWLLIgAIP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 119 FAVLCYFLIWYVPSVDQGKVVWYLIFYCCFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMtvevlgtlIGTAIQGQI 198
Cdd:TIGR00792 80 FSIVLVLLFTTPDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRR--------FGATLGGLL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 199 VGMANAPCISteidlnstglevapdvnitdpHVSLQDLRNAYMIASGVICAIYVVCAVVLFLGVKEQKDTCRVRTEP-MS 277
Cdd:TIGR00792 152 VAVIVLPLVS---------------------YFGGGDDKFGWFMFALVLALIGVVSLIICFFGTKERYSEIPKNIEKkLS 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 278 FFQGICMVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCIYNLGFRNDFQNVLLVIMLSATLAIPFWQWFLTKFGKKTAV 357
Cdd:TIGR00792 211 LKQIFKALFKNDQLLILCLAYLFYNLAFNIKNGVQVYYFTYVLGDPELFSYMGSIAIVAGLIGVLLFPRLVKKFGRKILF 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 358 YIGttSVVPFLISVVL--VPSSLAVTYIASFAAGVSVAAAFLLPWSMLPDVVDDFKVQNpesqGH--EAIFYSFYVFFTK 433
Cdd:TIGR00792 291 AGG--ILLMVLGYLIFffAGSNLPLILVLIILAGFGQNIVTGLVWALVADTVDYGEWKT----GIraEGLVYSVRTFVRK 364
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 57525841 434 FASGVSLGVSTLSLDFAGYVTrGCTQPGEVKLTLKILVSAAP 475
Cdd:TIGR00792 365 LGQALAGFFVGLILGIIGYVA-NAAQSPITLNGIKILMFAVP 405
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
33-495 |
8.08e-22 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 97.87 E-value: 8.08e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 33 SRLSVCSKLCYAIGGAPYQITGCAIGFFLQIYLLDVALLDPFYASIILFVGRAWDAVTDPTVGFLVSRTPwTRFGRMMPW 112
Cdd:PRK09669 4 SQLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTR-TRHGQFRPY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 113 IV-LSTPFAVLCyFLIWYVPSV-DQGKVVWYLIFYCCFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTLI 190
Cdd:PRK09669 83 LLwFAIPFGVVC-LLTFYTPDFgATGKIIYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGLI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 191 gtaiqgqiVGMANAPCISteidlnstglevapdvnitdpHVSLQDLRNAYMIASGVICAIYVVCAVVLFLGVKEQkdtCR 270
Cdd:PRK09669 162 --------VSVIALPLVD---------------------ILGKGDEQKGYFYAMMVMGLLGVVLFFCCFFMTKER---YT 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 271 VRTEPM-SFFQGICMVMGHGPYaKLVMGFLFTSLAFMLLEGNFALFCIYNLGFRNDFQNVLLVI-MLSATLAIPFWQWFL 348
Cdd:PRK09669 210 PEVDNSsSVWKDLKLLLGNSQW-RIMFIFNVVLLTAVVTRGGATLYYVNYVLLRPDLATLFLVTgMIAGLFGALLSERLL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 349 TKFGKKTAVYIGTTSVVPFLISVVLVP-SSLAVTYIASFAAGVSVAAAFLLPWSMLPDVVDdfkVQNPES-QGHEAIFYS 426
Cdd:PRK09669 289 GKFDRVRAFKWTIVAFVILSALIFFIPpSNVWLIFALNILFNFIQNLTTPLQWSMFSDVVD---YEEKRSgRRLDGLVFS 365
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 57525841 427 FYVFFTKFasGVSLG--VSTLSLDFAGYVTRGCTQPGEVKLTLKILVSAAPIVLIIIGLLIFISYPINEEK 495
Cdd:PRK09669 366 TNLFAIKL--GLAIGgaVVGWILAWVDYVGGAAVQSASVLTTINLLFTVIPGVLFAGMAIILNFYKLNDAR 434
|
|
| PRK09848 |
PRK09848 |
glucuronide transporter; Provisional |
60-495 |
3.65e-14 |
|
glucuronide transporter; Provisional
Pssm-ID: 182109 [Multi-domain] Cd Length: 448 Bit Score: 74.44 E-value: 3.65e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 60 FLQIYLLDVALLDPFYASIILFVGRAWDAVTDPTVGFLVSRTPwTRFGRMMPWIVLSTPFAVLCYFLIWYVPS--VDQGK 137
Cdd:PRK09848 30 FLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVN-TRWGKFRPFLLFGTAPLMIFSVLVFWVPTdwSHSSK 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 138 VVWYLIFYCCFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMtvevlgtlIGTAIQGQIVGMANAPCISteidlnstg 217
Cdd:PRK09848 109 VVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGAARG--------IAASLTFVCLAFLIGPSIK--------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 218 levapdvnitdpHVSLQDLRNAYmiaSGVICAIYVVCAVVLFLGVKEQKDTCRVRTEPMSFFQGICMVMGHGPYAKLVMG 297
Cdd:PRK09848 172 ------------NSSPEEMVSVY---HFWTIVLAIAGMVLYFICFKSTRENVVRIVAQPSLKISLQTLKRNRPLFMLCIG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 298 FLFTSLAFMLLEGNFALFCIYNLGFRNDFQNVLLVIMLSATLAI-PFWQWFLTKFGKKTAVYIGTT-SVVPFLISVVLVP 375
Cdd:PRK09848 237 ALCVLISTFAVSASSLFYVRYVLNDTGLFTVLVLVQNLVGTVASaPLVPGMVARIGKKNTFLIGALlGTCGYLLFFWVSV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 376 SSLAVTYIASFAAGVSVAAAFLLPWSMLPDVVD--DFKVqnpeSQGHEAIFYSFYVFFTKFASGVSLGVSTLSLDFAGYV 453
Cdd:PRK09848 317 WSLPVALVALAIASIGQGVTMTVMWALEADTVEygEYLT----GVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGYI 392
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 57525841 454 TrGCTQPGEVKLTLKILVSAAPIVLIIIGLLIFISYPINEEK 495
Cdd:PRK09848 393 A-NQVQTPEVIMGIRTSIALVPCGFMLLAFVIIWFYPLTDKK 433
|
|
| PRK10429 |
PRK10429 |
melibiose:sodium transporter MelB; |
35-453 |
1.35e-13 |
|
melibiose:sodium transporter MelB;
Pssm-ID: 182453 Cd Length: 473 Bit Score: 72.82 E-value: 1.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 35 LSVCSKLCYAIGGAPYQITGCAIGFFLQIYLLDVALLDPFYASIILFVGRAWDAVTDPTVGFLVSRTPwTRFGRMMPWIV 114
Cdd:PRK10429 3 ISMTTKLSYGFGAFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNNTR-SRWGKFKPWIL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 115 LSTPFAVLCYFLI---WYVPSVDQgkVVWYLIFYCCFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTLIG 191
Cdd:PRK10429 82 IGTLANSVVLFLLfsaHLFEGTAQ--YVFVCVTYILWGMTYTIMDIPFWSLVPTLTLDKREREQLVPYPRFFASLAGFVT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 192 TAIQGQIVGmanapcisteidlnstglevapdvnitdpHVSLQDLRNAYMIASGVICAIYVVCAVVLFLGVKEQKDTCRV 271
Cdd:PRK10429 160 AGFTLPFVN-----------------------------YVGGGDRGFGFQMFTLVLIAFFIVSTIITLRNVHEVYSSDNQ 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 272 RTEPMSFFQgicmvmghgpyAKLVMGFLF-----TSLAFMLLEGNFALFCI---------YNLGFRNDFQNVLLVIMLSA 337
Cdd:PRK10429 211 VSAEGSHLT-----------LKDIVALIYkndqlSCLLGMALAYNIASNIIngfaiyyftYVIGDADLFPYYLSYAGAAN 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 338 TLAIPFWQWFLTKFGKKTaVYIGtTSVVPFLISVVLV------PSSLAVTYIASFAAGVSVAAAFLLPWSMLPDVVD--D 409
Cdd:PRK10429 280 LVTLILFPRLVKSLSRRI-LWAG-ASIFPVLSCGVLLlmglaaPHNALLIVIAGILLNIGTALFWVLQVIMVADTVDygE 357
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 57525841 410 FKVqnpeSQGHEAIFYSFYVFFTKFASGVSLGVSTLSLDFAGYV 453
Cdd:PRK10429 358 YKL----GIRCESIAYSVQTMVVKGGSAFAAFFIGVVLGLIGYV 397
|
|
| PRK11462 |
PRK11462 |
putative transporter; Provisional |
35-201 |
4.27e-13 |
|
putative transporter; Provisional
Pssm-ID: 183145 Cd Length: 460 Bit Score: 71.12 E-value: 4.27e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 35 LSVCSKLCYAIGGAPYQITGCAIGFFLQIYLLDVALLDPFYASIILFVGRAWDAVTDPTVGFLVSRTPwTRFGRMMPWIV 114
Cdd:PRK11462 6 LSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTR-SRWGKFRPWVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 115 L-STPFAVLCyFLIWYVPSVD-QGKVVWYLIFYCCFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTLIGT 192
Cdd:PRK11462 85 FgALPFGIVC-VLAYSTPDLSmNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGMLST 163
|
....*....
gi 57525841 193 AIQGQIVGM 201
Cdd:PRK11462 164 VLMMPLVNL 172
|
|
| MFS_MFSD12 |
cd17491 |
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ... |
60-439 |
2.47e-07 |
|
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341044 Cd Length: 438 Bit Score: 53.03 E-value: 2.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 60 FLQIYLLDVALLDPFYASIILFVGRAWDAVTDPTVGFLVSRTPW-TRFGRMMPWIVLSTPFAVLCYFLIWYVP-SVDQGK 137
Cdd:cd17491 21 YLLVYFHLVLGFSSALAGILLLIGQVADAISTPLVGYESDRTNGcGKYGRRKSWHLIGTICVLLSFPFIFNPClGCSDST 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 138 VVWY-LIFYCCFQTL-QTCF---HVPYSALTMFISTEQKERDSATAYRMTVEVLGTLIGTAIQGQIVGmanapcISTEID 212
Cdd:cd17491 101 SEWAkLVYYGPFIIIfQFGWaavQISHLSLIPELTSDEHERVELTALRYAFTVIANITVYLIAWLLLQ------QSSGDS 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 213 LNSTGLEVAPDvnitdphvslqdlrnaYMIASGVICAIYVVCAVVLFLGVKEQKDTCRVRTEPMsffQGICMVMGHGPYA 292
Cdd:cd17491 175 VNPTSAQDLPI----------------FRNLSLIVVGIGFLFSLLFHLGTKEPRPPTDLSTTTN---EGEEVTAPEEPRL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 293 KL-----VMGFLFTSLAFML--LEGN-----FALFCIYNLGFRNDFQNVLLVIMLSATLAIPFWQWFLTKF-GKKTAVYI 359
Cdd:cd17491 236 TWkewlrEPQFYQVALLYMCtrLIVNlsqvyIPLYLTETLQLPKESIAIVPLVMYVSGFLTSLVMKPINKKiGRKITYLL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 360 GTTSVVPFLISVVLVP--SSLAVTYIASFAAGVSVAAAFLLPWSMLPDVVDDFKvqnpESqghEAIFYSFYVFFTKFASG 437
Cdd:cd17491 316 GLLFVLGFCIWVWFQSgsSRTYEIYGAAVLLGVGSATLLVTSLSMTADLIGTNT----ES---GAFVYGAMSFTDKLSNG 388
|
..
gi 57525841 438 VS 439
Cdd:cd17491 389 IA 390
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
60-429 |
3.00e-07 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 52.63 E-value: 3.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 60 FLQIYLLDVaLLDPFYASIILFVGRAWDAVTDPTVGFLVSRTpWTRFGRMMPWIVLSTPFAVLCYFLIWYVPSV----DQ 135
Cdd:cd17313 21 YVPPILQTL-GLSHALIGFVWTLGPILGLFVQPLVGSLSDRC-NSRIGRRRPFILVGAPLAALGLILIPNAADIglalGD 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 136 GKVVWYLIFYCCFQTL-----QTCFHvPYSALtMFISTEQKERDSATAYRMTVEVLGTLIGTAIQGQIVgmanapciste 210
Cdd:cd17313 99 GPRTWALVLFVLGIVLldfamNVCQG-PVRAL-LPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILW----------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 211 idlnstglevapDVNITDPHVSLQdLRNAYMIASgvicAIYVVCAVVLFLGVKEQKDTCR-----VRTEPMSFFQGICMV 285
Cdd:cd17313 166 ------------DHNWFGFALGGN-LKVPFYIGA----IILLVCVLVTLFFVKEPPLSPEagehsENPSLGEVLKSLLKL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 286 MGHGPYA--KLVMGFLFTSLAFMLLEGNFALFC-------------IYNLGFRNDFQNVLLVIMLSATLAIPFwQWFLTK 350
Cdd:cd17313 229 LKIMPRSllRLLLVIFFWWIAFFPFELFFTDYMgeevyhgtsaassHYGAGVRMGAWGLLIFSLAFLIFSLPI-GKLGKK 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 351 FGKKTAVYIGTTSVVPFLISVVLVPSSLAVTyIASFAAGVSVAAAFLLPWSMLPDVVDDfkvqNPESQG-HEAIFYSFYV 429
Cdd:cd17313 308 IGRKKVYLIGLVLFAVGMALMALVHNVTVAL-VLFALGGIGWATININPYPLVSDYHSE----SGRGQGtDTGLLNLAIS 382
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
240-408 |
2.01e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 40.64 E-value: 2.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 240 YMIASGVICAIYVVCAVVLFLGV--------KEQKDTCRVRTEPMSFFQGICMVMGHGPYAKLVMGFLFTSLAFMLLEGN 311
Cdd:cd17325 142 LLADALGYRAPFLVCAALALLALvlallllpEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPF 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 312 FALFCIYNLGFrNDFQN--VLLVIMLSATLAIPFWQWFLTKFGKKTAVYIGTTSVVPFLISVVLVPSSLAVtYIASFAAG 389
Cdd:cd17325 222 LPLYAAELGGL-SPAQIglLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLL-LLLLALLG 299
|
170
....*....|....*....
gi 57525841 390 VSVAAAFLLPWSMLPDVVD 408
Cdd:cd17325 300 LGLGLVFPATLALLADIVP 318
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
243-436 |
3.65e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 39.75 E-value: 3.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 243 ASGVICAI-YVVCAVVLFLGVKEQKDTCRVRTEPMSF--FQGICMVMGHGPYAKLVMGFLftsLAFMLLegNFALFCIY- 318
Cdd:COG2270 185 ISFLLTALwWLLFALPLFLFLPERPRPGPAPPRGAVRagFRELRRTLRELRRYRDLLRFL---LAYFFY--RDGVQTVIa 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 319 --------NLGFrnDFQNVLLVIMLSATLAIPF---WQWFLTKFGKKTAVYIGTTSVVPFLISVVLVPSSLAVtYIASFA 387
Cdd:COG2270 260 fagiyaagVLGF--STTELIVFGLLVQIVAALGallFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAF-WILGLL 336
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 57525841 388 AGVSVAAAFLLPWSMLPDVVddfkvqnPEsqGHEAIFYSFYVFFTKFAS 436
Cdd:COG2270 337 IGLVMGGIQALSRSLLARLI-------PP--GREAEFFGLYALSGKAAS 376
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
236-407 |
8.14e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 38.71 E-value: 8.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 236 LRNAYMIASgvicAIYVVCAVVLFLGVKE--QKDTCRVRTEPMSFFQgicmVMGHGPYAKLVMGFLFTSLAFMLLEGNFA 313
Cdd:COG2223 158 WRNAFLILG----ILLLVVAVLAWLFLRDppAGAAAAAKASLRDQLE----ALRDPRFWLLSLLYFGTFGSFIGFSSWLP 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57525841 314 LFCIYNLGF-RNDFQNVLLVIMLSATLAIPFWQWFLTKFGKKTAVYIGTTSVVPFLISVVLVPSSLAVTYIASFAAGVSV 392
Cdd:COG2223 230 PYLVDQFGLsAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLAL 309
|
170
....*....|....*
gi 57525841 393 AAAFLLPWSMLPDVV 407
Cdd:COG2223 310 GGGNGAVFALVPDIF 324
|
|
| |
