NCBI Conserved Domain Search

Conserved domains on [gi|47577249|ref|NP_001000574|]

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olfactory receptor Olr729 [Rattus norvegicus]

Protein Classification

olfactory receptor family 4A protein( domain architecture ID 11610412)

olfactory receptor family 4A protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

23-289

2.55e-169

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 470.16 E-value: 2.55e-169

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  23 RILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGA 102
Cdd:cd15939   1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 103 HFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPL 182
Cdd:cd15939  81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 183 LELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHSLRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15939 161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                       250       260
                ....*....|....*....|....*..
gi 47577249 263 LSIDKNMAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15939 241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

23-289

2.55e-169

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 470.16 E-value: 2.55e-169

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  23 RILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGA 102
Cdd:cd15939   1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 103 HFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPL 182
Cdd:cd15939  81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 183 LELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHSLRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15939 161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                       250       260
                ....*....|....*....|....*..
gi 47577249 263 LSIDKNMAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15939 241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

29-300

8.68e-41

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 143.03 E-value: 8.68e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249    29 FLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGGV 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249   109 EIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLELACT 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249   189 DTYV---IGLLVVANSGVIcllNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYM--RPSTT 262
Cdd:pfam13853 161 DIKVnniYGLFVVTSTFGI---DSLLIVLSYGLILRTvLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHN 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 47577249   263 LS--IDKNMAVFYGILTPMLNPLIYTLRNEEVKDAMRKLF 300
Cdd:pfam13853 238 VPplLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

PHA03087

G protein-coupled chemokine receptor-like protein; Provisional

24-148

5.82e-03

G protein-coupled chemokine receptor-like protein; Provisional

Pssm-ID: 222976 [Multi-domain] Cd Length: 335 Bit Score: 37.84 E-value: 5.82e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249   24 ILFVVFLVIYAVTVFGNMlIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLaPKLIADSLYEGTTLSYEGC--MAQLFG 101
Cdd:PHA03087  42 ILIVVYSTIFFFGLVGNI-IVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTL-PFQIYYYILFQWSFGEFACkiVSGLYY 119

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 47577249  102 AHFLggVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWL 148
Cdd:PHA03087 120 IGFY--NSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWI 164

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

23-289

2.55e-169

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 470.16 E-value: 2.55e-169

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  23 RILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGA 102
Cdd:cd15939   1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 103 HFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPL 182
Cdd:cd15939  81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 183 LELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHSLRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15939 161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                       250       260
                ....*....|....*....|....*..
gi 47577249 263 LSIDKNMAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15939 241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

25-289

3.62e-134

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 381.17 E-value: 3.62e-134

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  25 LFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHF 104
Cdd:cd15226   3 LFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 105 LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLE 184
Cdd:cd15226  83 FGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 185 LACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHSLRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTTLS 264
Cdd:cd15226 163 LACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTFP 242

                       250       260
                ....*....|....*....|....*
gi 47577249 265 IDKNMAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15226 243 VDKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

24-289

9.45e-125

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 357.56 E-value: 9.45e-125

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd13954   2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd13954  82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd13954 162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTiLKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSS 241

                       250       260
                ....*....|....*....|....*....
gi 47577249 263 LSIDKN--MAVFYGILTPMLNPLIYTLRN 289
Cdd:cd13954 242 YSSDLDkvVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

24-296

1.53e-121

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 349.45 E-value: 1.53e-121

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15225   2 LLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15225  82 FLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15225 162 KLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTiLKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577249 263 LS--IDKNMAVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15225 242 YSpeTDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

23-289

9.68e-118

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 339.70 E-value: 9.68e-118

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  23 RILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGA 102
Cdd:cd15936   1 FFLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 103 HFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPL 182
Cdd:cd15936  81 HFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 183 LELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHSLRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15936 161 IKLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQT 240

                       250       260
                ....*....|....*....|....*..
gi 47577249 263 LSIDKNMAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15936 241 FPMDKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

24-289

1.82e-117

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 339.10 E-value: 1.82e-117

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15230   2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15230  82 VFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15230 162 KLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITiLRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSS 241

                       250       260
                ....*....|....*....|....*....
gi 47577249 263 LSIDKNM--AVFYGILTPMLNPLIYTLRN 289
Cdd:cd15230 242 YSLDQDKvvSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

24-289

1.13e-114

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 331.71 E-value: 1.13e-114

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15940   2 AFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15940  82 LFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHSLRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTTL 263
Cdd:cd15940 162 KLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSF 241

                       250       260
                ....*....|....*....|....*.
gi 47577249 264 SIDKNMAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15940 242 SEDKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

10-300

1.05e-108

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 317.68 E-value: 1.05e-108

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  10 FFMLGLSQRPEIQRILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTT 89
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  90 LSYEGCMAQLFGAHFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGP 169
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 170 NVINHFVCDLYPLLELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALF 248
Cdd:cd15410 161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTiLRIRSAEGRQKAFSTCASHLTAITIF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 47577249 249 FVPCIFSYMRPST--TLSIDKNMAVFYGILTPMLNPLIYTLRNEEVKDAMRKLF 300
Cdd:cd15410 241 HGTILFMYCRPSSsySLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

9-300

1.69e-108

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 317.00 E-value: 1.69e-108

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249   9 EFFMLGLSQRPEIQRILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGT 88
Cdd:cd15943   1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  89 TLSYEGCMAQLFGAHFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCG 168
Cdd:cd15943  81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 169 PNVINHFVCDLYPLLELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVAL 247
Cdd:cd15943 161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAiLRIHSSEGRRKAFSTCASHLMAVTI 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47577249 248 FFVPCIFSYMRPST--TLSIDKNMAVFYGILTPMLNPLIYTLRNEEVKDAMRKLF 300
Cdd:cd15943 241 FYGTTLFMYLRPSSsySLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

24-289

1.44e-107

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 313.65 E-value: 1.44e-107

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15911   2 LLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15911  82 SLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15911 162 KLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTiLRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTN 241

                       250       260
                ....*....|....*....|....*....
gi 47577249 263 LSID--KNMAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15911 242 TSRDlnKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

25-296

1.54e-107

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 314.20 E-value: 1.54e-107

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  25 LFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHF 104
Cdd:cd15231   3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 105 LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLE 184
Cdd:cd15231  83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 185 LACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTTL 263
Cdd:cd15231 163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTiLKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGY 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577249 264 SIDKN--MAVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15231 243 SLDKDtlISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

22-296

3.13e-106

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 310.69 E-value: 3.13e-106

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  22 QRILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFG 101
Cdd:cd15235   1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 102 AHFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYP 181
Cdd:cd15235  81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 182 LLELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPS 260
Cdd:cd15235 161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAvLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47577249 261 TTLSIDKNM--AVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15235 241 SSYSADKDRvaTVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

24-298

6.86e-106

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 309.96 E-value: 6.86e-106

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15417   2 ILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15417  82 GMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15417 162 SLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTiLKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSS 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47577249 263 LSI--DKNMAVFYGILTPMLNPLIYTLRNEEVKDAMRK 298
Cdd:cd15417 242 HSQdqDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

25-296

7.07e-106

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 309.91 E-value: 7.07e-106

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  25 LFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHF 104
Cdd:cd15229   3 LFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 105 LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLE 184
Cdd:cd15229  83 FAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLP 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 185 LACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT- 262
Cdd:cd15229 163 LSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTiLRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSAs 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577249 263 -LSIDKNMAVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15229 243 sSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

25-289

1.79e-105

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 308.34 E-value: 1.79e-105

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  25 LFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHF 104
Cdd:cd15938   3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 105 LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLE 184
Cdd:cd15938  83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 185 LACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHSLRyhSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTTLS 264
Cdd:cd15938 163 LACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTIR--STEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTFP 240

                       250       260
                ....*....|....*....|....*
gi 47577249 265 IDKNMAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15938 241 VDKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

25-296

1.15e-104

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 306.64 E-value: 1.15e-104

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  25 LFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHF 104
Cdd:cd15429   3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 105 LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLE 184
Cdd:cd15429  83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 185 LACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTTL 263
Cdd:cd15429 163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAiLRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577249 264 SI--DKNMAVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15429 243 SAlqEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

24-298

1.35e-104

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 306.60 E-value: 1.35e-104

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15416   2 ILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15416  82 TFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15416 162 KLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAiLRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSS 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47577249 263 LSIDKN--MAVFYGILTPMLNPLIYTLRNEEVKDAMRK 298
Cdd:cd15416 242 YSMDQNkvVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

24-289

5.18e-104

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 304.79 E-value: 5.18e-104

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15912   2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15912  82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15912 162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTiLRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQS 241

                       250       260
                ....*....|....*....|....*....
gi 47577249 263 --LSIDKNMAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15912 242 ssLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

24-298

5.23e-104

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 305.01 E-value: 5.23e-104

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15411   2 PLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15411  82 ALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15411 162 KLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTiLKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSS 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47577249 263 LSIDKN--MAVFYGILTPMLNPLIYTLRNEEVKDAMRK 298
Cdd:cd15411 242 YSLGQDkvASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

10-293

6.18e-103

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 302.70 E-value: 6.18e-103

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  10 FFMLGLSQRPEIQRILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTT 89
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  90 LSYEGCMAQLFGAHFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGP 169
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 170 NVINHFVCDLYPLLELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALF 248
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATiLRMRSAEGRHKAFSTCASHLTAVTLF 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 47577249 249 FVPCIFSYMRPST--TLSIDKNMAVFYGILTPMLNPLIYTLRNEEVK 293
Cdd:cd15408 241 YGSLAFMYLRPSSrySLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

23-289

5.16e-102

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 299.58 E-value: 5.16e-102

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  23 RILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGA 102
Cdd:cd15237   1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 103 HFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPL 182
Cdd:cd15237  81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 183 LELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPST 261
Cdd:cd15237 161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATiLRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 47577249 262 TLSI--DKNMAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15237 241 THSPdqDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

24-289

2.02e-101

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 297.98 E-value: 2.02e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15431   2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIfQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15431  82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLTM-PLHFCGPNVINHFFCEVQALL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15431 161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAvLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSK 240

                       250       260
                ....*....|....*....|....*....
gi 47577249 263 LSIDKN--MAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15431 241 SSSDQDkiISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

24-289

9.97e-101

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 296.29 E-value: 9.97e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSL-ASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGA 102
Cdd:cd15935   2 LLFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 103 HFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPL 182
Cdd:cd15935  82 HFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 183 LELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHSLRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15935 162 IKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSS 241

                       250       260
                ....*....|....*....|....*..
gi 47577249 263 LSIDKNMAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15935 242 SSVDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

23-289

7.39e-100

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 294.14 E-value: 7.39e-100

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  23 RILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGA 102
Cdd:cd15918   1 QLLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 103 HFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPL 182
Cdd:cd15918  81 LLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 183 LELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPST 261
Cdd:cd15918 161 LKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAvLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 47577249 262 TLSIDKNM--AVFYGILTPMLNPLIYTLRN 289
Cdd:cd15918 241 SHSASKDSvaAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

24-298

7.91e-100

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 294.70 E-value: 7.91e-100

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15409   2 PLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15409  82 FSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15409 162 KISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTiLKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSL 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47577249 263 LSIDKNM--AVFYGILTPMLNPLIYTLRNEEVKDAMRK 298
Cdd:cd15409 242 YALDQDMmdSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

26-289

1.36e-99

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 293.59 E-value: 1.36e-99

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  26 FVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFL 105
Cdd:cd15227   4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 106 GGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLEL 185
Cdd:cd15227  84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 186 ACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTTLS 264
Cdd:cd15227 164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTvLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243

                       250       260
                ....*....|....*....|....*..
gi 47577249 265 --IDKNMAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15227 244 slLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

25-298

1.51e-98

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 291.24 E-value: 1.51e-98

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  25 LFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHF 104
Cdd:cd15415   3 LFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 105 LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLE 184
Cdd:cd15415  83 FVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 185 LACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTTL 263
Cdd:cd15415 163 LSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAiLRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQY 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577249 264 SID--KNMAVFYGILTPMLNPLIYTLRNEEVKDAMRK 298
Cdd:cd15415 243 SLEqeKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

24-298

3.53e-98

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 290.36 E-value: 3.53e-98

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15419   2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15419  82 LFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15419 162 KLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTiLRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAV 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47577249 263 LSI--DKNMAVFYGILTPMLNPLIYTLRNEEVKDAMRK 298
Cdd:cd15419 242 SSPeqSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

25-296

7.48e-98

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 289.35 E-value: 7.48e-98

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  25 LFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIAD-SLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15916   3 LFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGfLEPGGKVISFGGCVAQLYFFH 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15916  83 FLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15916 163 KLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAiLRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSK 242

                       250       260       270
                ....*....|....*....|....*....|....
gi 47577249 263 LSIDKNMAVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15916 243 EALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

24-289

3.79e-97

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 287.28 E-value: 3.79e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15915   2 FLFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15915  82 FLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHSL--RYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPST 261
Cdd:cd15915 162 KLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLllKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSS 241

                       250       260       270
                ....*....|....*....|....*....|
gi 47577249 262 TLSIDKNM--AVFYGILTPMLNPLIYTLRN 289
Cdd:cd15915 242 GDSLEQDRivALLYTVVTPVLNPLIYTLRN 271

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

10-298

4.29e-97

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 288.18 E-value: 4.29e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  10 FFMLGLSQRPEIQRILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTT 89
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  90 LSYEGCMAQLFGAHFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGP 169
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 170 NVINHFVCDLYPLLELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALF 248
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITvLKIRSAEGRFKAFSTCASHLTAVGLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577249 249 FVPCIFSYMRPSTTLSI--DKNMAVFYGILTPMLNPLIYTLRNEEVKDAMRK 298
Cdd:cd15945 241 YGTLLFMYLRPSSSYSLdtDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

24-289

7.61e-97

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 286.46 E-value: 7.61e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15232   2 LLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15232  82 WSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15232 162 LLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSiLRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSS 241

                       250       260
                ....*....|....*....|....*....
gi 47577249 263 LSI--DKNMAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15232 242 YSPekDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

24-296

1.02e-96

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 286.37 E-value: 1.02e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15421   2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15421  82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15421 162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTvLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSY 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577249 263 LS--IDKNMAVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15421 242 HSpeQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

24-298

3.79e-96

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 284.98 E-value: 3.79e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15413   2 PLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15413  82 TFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15413 162 ALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAiLRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSS 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47577249 263 --LSIDKNMAVFYGILTPMLNPLIYTLRNEEVKDAMRK 298
Cdd:cd15413 242 hsLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

24-289

9.85e-96

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 283.55 E-value: 9.85e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15937   2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15937  82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHSLRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTTL 263
Cdd:cd15937 162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSF 241

                       250       260
                ....*....|....*....|....*.
gi 47577249 264 SIDKNMAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15937 242 PMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

24-298

3.08e-95

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 282.75 E-value: 3.08e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15412   2 LLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15412  82 ALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYV--IGLLVVANSGVICLLNFLMLgtSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPS 260
Cdd:cd15412 162 KLSCSDTYVkeTAMFIVAGFNLSSSLLIILI--SYLFILIAiLRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPP 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 47577249 261 TTLSI--DKNMAVFYGILTPMLNPLIYTLRNEEVKDAMRK 298
Cdd:cd15412 240 SEESVeqSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

14-299

3.19e-95

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 283.10 E-value: 3.19e-95

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  14 GLSQRPEIQRILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYE 93
Cdd:cd15406   1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  94 GCMAQLFGAHFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVIN 173
Cdd:cd15406  81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 174 HFVCDLYPLLELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPC 252
Cdd:cd15406 161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSiLRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 47577249 253 IFSYMRPSTTLSID--KNMAVFYGILTPMLNPLIYTLRNEEVKDAMRKL 299
Cdd:cd15406 241 IFMYLKPSSSSSMTqeKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

24-296

5.63e-94

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 279.70 E-value: 5.63e-94

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15228   2 ILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15228  82 FLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15228 162 KLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISiLKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPS 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 47577249 263 LSIDKNMAVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15228 242 PVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

23-289

7.91e-94

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 278.74 E-value: 7.91e-94

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  23 RILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGA 102
Cdd:cd15947   1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 103 HFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPL 182
Cdd:cd15947  81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 183 LELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPST 261
Cdd:cd15947 161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAvLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 47577249 262 TLSID--KNMAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15947 241 SYSQDqgKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

25-296

1.16e-91

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 273.82 E-value: 1.16e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  25 LFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHF 104
Cdd:cd15420   3 LFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 105 LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLE 184
Cdd:cd15420  83 LAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 185 LACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTTL 263
Cdd:cd15420 163 LACADTWINEILIFAGCVFILLGPFSLILISYLHILAAiLKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577249 264 S--IDKNMAVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15420 243 SaeQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

10-300

6.14e-91

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 272.43 E-value: 6.14e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  10 FFMLGLSQRPEIQRILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTT 89
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  90 LSYEGCMAQLFGAHFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGP 169
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 170 NVINHFVCDLYPLLELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALF 248
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAiLRMRSAEGRRKAFSTCASHFTGVTLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 47577249 249 FVPCIFSYMRPSTTLSI--DKNMAVFYGILTPMLNPLIYTLRNEEVKDAMRKLF 300
Cdd:cd15944 241 YGTVIFMYLRPTSVYSLdqDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

25-289

6.87e-91

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 271.46 E-value: 6.87e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  25 LFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHF 104
Cdd:cd15224   3 LFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 105 LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLE 184
Cdd:cd15224  83 LACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLN 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 185 LACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTTL 263
Cdd:cd15224 163 LSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTvLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAIS 242

                       250       260
                ....*....|....*....|....*...
gi 47577249 264 SIDKN--MAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15224 243 SFDSNklVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

23-296

2.04e-88

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 265.45 E-value: 2.04e-88

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  23 RILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGA 102
Cdd:cd15424   1 ILLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 103 HFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPL 182
Cdd:cd15424  81 LSLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 183 LELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRP-- 259
Cdd:cd15424 161 LKLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASvLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPrs 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577249 260 STTLSIDKNMAVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15424 241 GSTPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

24-289

3.12e-87

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 262.31 E-value: 3.12e-87

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15430   2 LLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15430  82 AMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPST- 261
Cdd:cd15430 162 KLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTiLRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSk 241

                       250       260
                ....*....|....*....|....*....
gi 47577249 262 -TLSIDKNMAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15430 242 nAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

24-302

3.93e-87

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 262.36 E-value: 3.93e-87

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15414   2 PLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15414  82 LFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15414 162 SLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAiLRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSS 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 47577249 263 LS--IDKNMAVFYGILTPMLNPLIYTLRNEEVKDAMRKLFTR 302
Cdd:cd15414 242 SSldLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRR 283

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

24-296

1.12e-86

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 260.94 E-value: 1.12e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLAS-PMYFFLSNLSFIDTCYSSSLAPKLIADSLY-EGTTLSYEGCMAQLFG 101
Cdd:cd15941   2 LFFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTlSGRTISFEGCVVQLYA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 102 AHFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYP 181
Cdd:cd15941  82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 182 LLELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPS 260
Cdd:cd15941 162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAvLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577249 261 TTLSIDKNMAVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15941 242 SSQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

23-296

3.43e-86

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 259.62 E-value: 3.43e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  23 RILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGA 102
Cdd:cd15434   1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 103 HFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPL 182
Cdd:cd15434  81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 183 LELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPST 261
Cdd:cd15434 161 IKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAvLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKN 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577249 262 TLS--IDKNMAVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15434 241 SVSqdQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

24-289

1.42e-85

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 258.07 E-value: 1.42e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15914   2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15914  82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15914 162 SLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVvLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKS 241

                       250       260
                ....*....|....*....|....*....
gi 47577249 263 LSI--DKNMAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15914 242 YSLdyDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

25-298

8.37e-84

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 253.88 E-value: 8.37e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  25 LFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHF 104
Cdd:cd15407   3 LFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 105 LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLE 184
Cdd:cd15407  83 FATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 185 LACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTTL 263
Cdd:cd15407 163 LSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITiLRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSH 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577249 264 SI--DKNMAVFYGILTPMLNPLIYTLRNEEVKDAMRK 298
Cdd:cd15407 243 SMdtDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

24-296

1.31e-83

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 253.17 E-value: 1.31e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15432   2 VLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15432  82 GLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15432 162 KLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAvLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSN 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577249 263 LSID--KNMAVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15432 242 SSHDrgKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

22-299

2.69e-83

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 252.40 E-value: 2.69e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  22 QRILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFG 101
Cdd:cd15418   1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 102 AHFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYP 181
Cdd:cd15418  81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 182 LLELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPS 260
Cdd:cd15418 161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAiLRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47577249 261 T--TLSIDKNMAVFYGILTPMLNPLIYTLRNEEVKDAMRKL 299
Cdd:cd15418 241 SshTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

25-296

2.75e-83

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 252.35 E-value: 2.75e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  25 LFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHF 104
Cdd:cd15942   3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 105 LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLE 184
Cdd:cd15942  83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 185 LACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTTL 263
Cdd:cd15942 163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAiLKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQD 242

                       250       260       270
                ....*....|....*....|....*....|...
gi 47577249 264 SIDKNMAVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15942 243 PLDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

24-296

5.20e-81

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 246.33 E-value: 5.20e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15234   2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15234  82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15234 162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSiLRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577249 263 LSIDKNM--AVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15234 242 HSSRKTAvaSVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

24-289

3.70e-80

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 244.15 E-value: 3.70e-80

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15913   2 LLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15913  82 SLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYI-VILHSLRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15913 162 ALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTlVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSG 241

                       250       260
                ....*....|....*....|....*....
gi 47577249 263 LS--IDKNMAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15913 242 NStgMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

24-296

4.95e-79

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 241.62 E-value: 4.95e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15233   2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15233  82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYI-VILHSLRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15233 162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAhVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSV 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577249 263 LSIDKN--MAVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15233 242 YSSDKDkvIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

25-296

8.55e-79

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 240.78 E-value: 8.55e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  25 LFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHF 104
Cdd:cd15405   3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 105 LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLE 184
Cdd:cd15405  83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQ 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 185 LACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTTL 263
Cdd:cd15405 163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNiLHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVG 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577249 264 SID--KNMAVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15405 243 SVNqgKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

25-296

6.37e-77

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 236.22 E-value: 6.37e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  25 LFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHF 104
Cdd:cd15428   3 LFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 105 LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLE 184
Cdd:cd15428  83 FGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 185 LACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRP--ST 261
Cdd:cd15428 163 LASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTvFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPksST 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577249 262 TLSIDKNMAVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15428 243 SKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

24-296

4.04e-76

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 234.28 E-value: 4.04e-76

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15236   2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15236  82 FFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15236 162 KLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATiLKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSN 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577249 263 LSIDKN--MAVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15236 242 NSSDKDivASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

24-289

4.32e-74

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 228.52 E-value: 4.32e-74

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15946   2 ILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15946  82 ALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15946 162 KLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAiLKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSN 241

                       250       260
                ....*....|....*....|....*....
gi 47577249 263 LSI--DKNMAVFYGILTPMLNPLIYTLRN 289
Cdd:cd15946 242 YSPerDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

24-296

8.10e-74

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 228.14 E-value: 8.10e-74

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15433   2 VLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLL 183
Cdd:cd15433  82 ALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTT 262
Cdd:cd15433 162 KLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAvLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHR 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577249 263 LSID--KNMAVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15433 242 YSQAhgKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

23-296

4.95e-61

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 195.59 E-value: 4.95e-61

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  23 RILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGA 102
Cdd:cd15223   1 HWLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 103 HFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPL 182
Cdd:cd15223  81 HFFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 183 LELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYM--RP 259
Cdd:cd15223 161 VSLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAvLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLtyRF 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577249 260 STTLSIDKN--MAVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15223 241 GKTIPPDVHvlLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

29-292

9.61e-56

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 181.81 E-value: 9.61e-56

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  29 FLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGGV 108
Cdd:cd15952   7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 109 EIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLELACT 188
Cdd:cd15952  87 ESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 189 DTYVIGLLVVANSGVIcLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMR----PSTTL 263
Cdd:cd15952 167 SIRINIIYGLFAISVL-VLDVILIALSYVLILRAvFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLThrfgHNIPR 245

                       250       260
                ....*....|....*....|....*....
gi 47577249 264 SIDKNMAVFYGILTPMLNPLIYTLRNEEV 292
Cdd:cd15952 246 YIHILLANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

27-292

1.11e-55

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 181.72 E-value: 1.11e-55

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  27 VVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLG 106
Cdd:cd15917   5 IPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFT 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 107 GVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLELA 186
Cdd:cd15917  85 AMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 187 CTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTTLSI 265
Cdd:cd15917 165 CGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAvLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHV 244

                       250       260       270
                ....*....|....*....|....*....|.
gi 47577249 266 DKN----MAVFYGILTPMLNPLIYTLRNEEV 292
Cdd:cd15917 245 PPHvhilLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

29-292

3.00e-52

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 172.60 E-value: 3.00e-52

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  29 FLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGGV 108
Cdd:cd15950   7 FCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 109 EIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLELACT 188
Cdd:cd15950  87 ESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 189 DTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTTLSIDK 267
Cdd:cd15950 167 DPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAvLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIYTQRFGQGVPP 246

                       250       260
                ....*....|....*....|....*....
gi 47577249 268 N----MAVFYGILTPMLNPLIYTLRNEEV 292
Cdd:cd15950 247 HtqvlLADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

29-292

1.80e-51

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 170.55 E-value: 1.80e-51

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  29 FLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGGV 108
Cdd:cd15221   7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 109 EIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLELACT 188
Cdd:cd15221  87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 189 DTYV--IGLLVVANSGVIclLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMR------- 258
Cdd:cd15221 167 DITVniWYGLTVALLTVG--LDVVLIAVSYALILRAvFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLThrfgrhi 244

                       250       260       270
                ....*....|....*....|....*....|....
gi 47577249 259 PSTTLSIDKNMavfYGILTPMLNPLIYTLRNEEV 292
Cdd:cd15221 245 PRHVHILLANL---YVLVPPMLNPIVYGVKTKQI 275

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

25-292

1.43e-47

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 160.74 E-value: 1.43e-47

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  25 LFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHF 104
Cdd:cd15222   3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 105 LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHlCVVLVGVAWLG-GFLHSLVQILLIFQLPFCGPNVINHFVCdLYP-L 182
Cdd:cd15222  83 FSFMESSVLLAMAFDRFVAICNPLRYASILTNS-RIAKIGLAIVLrSVLLLLPLPFLLKRLPFCHSNVLSHSYC-LHQdV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 183 LELACTDTYV---IGLLVVANS-GVICLLNFLmlgtSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCI---- 253
Cdd:cd15222 161 MKLACSDTRVnsiYGLFVVLSTmGLDSLLILL----SYVLILKTvLGIASREERLKALNTCVSHICAVLIFYVPMIglsm 236

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 47577249 254 ---FSYMRPSTTLSIdknMAVFYGILTPMLNPLIYTLRNEEV 292
Cdd:cd15222 237 vhrFGKHASPLVHVL---MANVYLLVPPVLNPIIYSVKTKQI 275

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

29-292

9.50e-46

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 155.88 E-value: 9.50e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  29 FLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGGV 108
Cdd:cd15953   7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 109 EIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLELACT 188
Cdd:cd15953  87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 189 DTYVIGL--LVVANsgVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMrpstTLSI 265
Cdd:cd15953 167 DTTINRIygLVVAL--LVVGLDLLLIALSYALIIRAvLRLSSKKARQKALNTCTAHICVILMSYTPALFSFL----THRF 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577249 266 DKNMAV--------FYGILTPMLNPLIYTLRNEEV 292
Cdd:cd15953 241 GQGIAPhihiilanLYLLVPPMLNPIIYGVKTKEI 275

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

29-292

8.80e-45

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 153.27 E-value: 8.80e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  29 FLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGGV 108
Cdd:cd15951   7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 109 EIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLELACT 188
Cdd:cd15951  87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 189 DTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMR----PSTTL 263
Cdd:cd15951 167 DTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAvFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLThrfgHNVPP 246

                       250       260
                ....*....|....*....|....*....
gi 47577249 264 SIDKNMAVFYGILTPMLNPLIYTLRNEEV 292
Cdd:cd15951 247 HVHILIANVYLLVPPMLNPIIYGVRTKQI 275

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

23-292

9.70e-43

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 148.09 E-value: 9.70e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  23 RILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGA 102
Cdd:cd15956   1 VWLSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 103 HFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRH------LCVVLVGVAWLGGFlhslvqILLIFQLPFCGPNVINHFV 176
Cdd:cd15956  81 HAFSAMESGVLVAMALDRFVAICNPLHYATILTLEvvakagLLLALRGVAIVIPF------PLLVCRLSFCASHTIAHTY 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 177 CDLYPLLELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFS 255
Cdd:cd15956 155 CEHMAVVKLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTvLRLPSPEARGKAFSTCSAHICVILFFYIPGLLS 234

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47577249 256 YM----RPSTTLSIDKNMAVFYGILTPMLNPLIYTLRNEEV 292
Cdd:cd15956 235 VLmhrfGHSVPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

29-300

8.68e-41

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 143.03 E-value: 8.68e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249    29 FLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGGV 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249   109 EIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLELACT 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249   189 DTYV---IGLLVVANSGVIcllNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYM--RPSTT 262
Cdd:pfam13853 161 DIKVnniYGLFVVTSTFGI---DSLLIVLSYGLILRTvLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHN 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 47577249   263 LS--IDKNMAVFYGILTPMLNPLIYTLRNEEVKDAMRKLF 300
Cdd:pfam13853 238 VPplLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

8-293

1.86e-40

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 142.61 E-value: 1.86e-40

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249   8 TEFFMLGLSQRPEIQRILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEG 87
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  88 TTLSYEGCMAQLFGAHFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFC 167
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 168 GPNVINHFVCDLYPLLELACTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHSL-RYHSVEGRRKALSTCGAHFTVVA 246
Cdd:cd15949 162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVqRLATSEARLKTFGTCVSHVCAIL 241

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47577249 247 LFFVPCIFSYM---------RPSTTLsidknMAVFYGILTPMLNPLIYTLRNEEVK 293
Cdd:cd15949 242 AFYVPIAVSSLihrfgqnvpPPTHIL-----LANFYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

29-293

8.00e-40

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 140.42 E-value: 8.00e-40

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  29 FLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGGV 108
Cdd:cd15948   8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 109 EIILLTVMAYDRYVAICKPLHYTTKMTRHLcVVLVGVAWLGGFLHSLVQI-LLIFQLPFCGPNVINHFVCDLYPLLELAC 187
Cdd:cd15948  88 ESAVLLAMAFDRYVAICNPLRYATILTNSV-ITKIGLAALARAVTLMTPLpFLLRRLPYCRSHVIAHCYCEHMAVVKLAC 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 188 TDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFS----YMRPSTT 262
Cdd:cd15948 167 GDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAvLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSstmhRFARHVA 246

                       250       260       270
                ....*....|....*....|....*....|.
gi 47577249 263 LSIDKNMAVFYGILTPMLNPLIYTLRNEEVK 293
Cdd:cd15948 247 PHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

29-292

1.48e-33

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 124.17 E-value: 1.48e-33

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  29 FLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGGV 108
Cdd:cd15954   7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 109 EIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLELACT 188
Cdd:cd15954  87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 189 DTYVIGLLVVANSGVICLLNFLMLGTSYIVILHS-LRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMR-----PSTT 262
Cdd:cd15954 167 NIRVDAIYGLMVALLIGGFDILCISVSYAMILRAvVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAhrfggHHIT 246

                       250       260       270
                ....*....|....*....|....*....|
gi 47577249 263 LSIDKNMAVFYGILTPMLNPLIYTLRNEEV 292
Cdd:cd15954 247 PHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

39-285

6.39e-33

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 122.02 E-value: 6.39e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249    39 GNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGT-TLSYEGCMAQLFGAHFLGGVEIILLTVMA 117
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249   118 YDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPnviNHFVCDLYPLLELACTDTYVIGLLV 197
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEG---NVTVCFIDFPEDLSKPVSYTLLISV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249   198 VAnsgviCLLNFLMLGTSYIVILHSLRYHSVEG--------RRKALSTCGAHFTVVALFFVPCIFSYMRPSTTLSIDKN- 268
Cdd:pfam00001 158 LG-----FLLPLLVILVCYTLIIRTLRKSASKQkssertqrRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSr 232

                         250       260
                  ....*....|....*....|....
gi 47577249   269 -------MAVFYGILTPMLNPLIY 285
Cdd:pfam00001 233 lldkalsVTLWLAYVNSCLNPIIY 256

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

29-292

4.82e-30

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 114.87 E-value: 4.82e-30

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  29 FLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGGV 108
Cdd:cd15955   7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 109 EIILLTVMAYDRYVAICKPLHYTTKMTRH-LCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLELAC 187
Cdd:cd15955  87 ESGILLAMALDRYVAICHPLRHSSILTPQvLLGIGVLVVVRAVVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 188 TDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHSL-RYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMR----PSTT 262
Cdd:cd15955 167 DDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVfRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAhrfgHHVA 246

                       250       260       270
                ....*....|....*....|....*....|
gi 47577249 263 LSIDKNMAVFYGILTPMLNPLIYTLRNEEV 292
Cdd:cd15955 247 PYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

25-289

6.24e-24

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 98.13 E-value: 6.24e-24

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  25 LFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHF 104
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 105 LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYPLLe 184
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSK- 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 185 lactdTYVIGLLVvansgVICLLNFLMLGTSYIVILHSLRYHSVEGRRKALSTCGAH------------FTVVALFFV-- 250
Cdd:cd00637 160 -----AYTIFLFV-----LLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRrrrrerkvtktlLIVVVVFLLcw 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 47577249 251 -PCIFSYM------RPSTTLSIDKNMAVFYGILTPMLNPLIYTLRN 289
Cdd:cd00637 230 lPYFILLLldvfgpDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

27-152

3.21e-14

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 71.47 E-value: 3.21e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  27 VVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLG 106
Cdd:cd14969   5 VYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLG 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47577249 107 GVEIILLTVMAYDRYVAICKPLHYTTKMTRHLcVVLVGVAWLGGFL 152
Cdd:cd14969  85 LVSISTLAALAFERYLVIVRPLKAFRLSKRRA-LILIAFIWLYGLF 129

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

24-296

1.09e-13

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 69.51 E-value: 1.09e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFlhsLVQILLIFQLPFCGPNVINHFVCDLYPLl 183
Cdd:cd14967  81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSL---LISLPPLVGWRDETQPSVVDCECEFTPN- 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 elactDTYVIGLLVVAnsgviCLLNFLMLGTSYIVILHSLRYHsvegrRKALSTcgahFTVVALFFVPC--------IFS 255
Cdd:cd14967 157 -----KIYVLVSSVIS-----FFIPLLIMIVLYARIFRVARRE-----LKAAKT----LAIIVGAFLLCwlpffiiyLVS 217

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 47577249 256 YMRPSTTLSIDKNMAVFY-GILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd14967 218 AFCPPDCVPPILYAVFFWlGYLNSALNPIIYALFNRDFRRAF 259

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

24-285

2.49e-10

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 60.06 E-value: 2.49e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLyegttlsyEGCMaqLFGAH 103
Cdd:cd15312   2 AMYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSV--------ESCW--YFGDL 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 F----------LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWlggflhsLVQILLIFQLPFCGPNV-- 171
Cdd:cd15312  72 FckihssldmmLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISW-------SVPCLFAFGVVFSEVNLeg 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 172 INHFVcdlyplLELACTDTYVigLLVVANSGVIC-LLNFLMLGTS----YIVILHSLRYH-------------------S 227
Cdd:cd15312 145 IEDYV------ALVSCTGSCV--LIFNKLWGVIAsLIAFFIPGTVmigiYIKIFFVARKHakvinnrpsvtkgdsknklS 216

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47577249 228 VEGRRKALSTCGAHFTVVALFFVPCIFS-----YMRPSTTLSIdKNMAVFYGILTPMLNPLIY 285
Cdd:cd15312 217 KKKERKAAKTLSIVMGVFLLCWLPFFVAtlidpFLNFSTPVDL-FDALVWLGYFNSTCNPLIY 278

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

28-148

8.26e-10

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 58.58 E-value: 8.26e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  28 VFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGG 107
Cdd:cd15336   6 VILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGI 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 47577249 108 VEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWL 148
Cdd:cd15336  86 TSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWL 126

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

24-148

8.71e-10

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 58.36 E-value: 8.71e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLaPKLIADSLYEGTTLSYEGCmaQLFGah 103
Cdd:cd15079   2 LLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKM-PIFIYNSFYEGWALGPLGC--QIYA-- 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47577249 104 FLGGV----EIILLTVMAYDRYVAICKPLHyTTKMTRHLCVVLVGVAWL 148
Cdd:cd15079  77 FLGSLsgigSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWL 124

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

24-165

9.99e-10

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 58.33 E-value: 9.99e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFID-------TCYSSSlapKLIADSLYEGTTLsyegCM 96
Cdd:cd15055   2 LLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADflvgllvMPFSMI---RSIETCWYFGDTF----CK 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47577249  97 AQLFGAHFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLP 165
Cdd:cd15055  75 LHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYDNLNQP 143

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

23-171

1.13e-09

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 58.01 E-value: 1.13e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  23 RILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFID--TCYSSSLaPKLIADslyegTTLSYEG----C- 95
Cdd:cd15196   1 KVEIAVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADllVALFNVL-PQLIWD-----ITYRFYGgdllCr 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  96 ------MAQLFGAHFlggveiiLLTVMAYDRYVAICKPLHYTTKMTRHlCVVLVGVAWLGGFLHSLVQiLLIFQLPFCGP 169
Cdd:cd15196  75 lvkylqVVGMYASSY-------VLVATAIDRYIAICHPLSSHRWTSRR-VHLMVAIAWVLSLLLSIPQ-LFIFSYQEVGS 145


                ..
gi 47577249 170 NV 171
Cdd:cd15196 146 GV 147

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

27-296

1.79e-09

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 57.30 E-value: 1.79e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  27 VVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDtCYSSSLAPKLIADSLYEGTTLSYEGCMAqLFGAHFLG 106
Cdd:cd14972   3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAAD-LLAGIAFVFTFLSVLLVSLTPSPATWLL-RKGSLVLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 107 GV-EIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWlggflhslVQILLIFQLPFCGPNVINHFVCDLYPLLEL 185
Cdd:cd14972  81 LLaSAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVW--------VWSVLLALLPVLGWNCVLCDQESCSPLGPG 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 186 AcTDTYVIgLLVVANSGVICLLNFLMLGTSYIVILH----SLRYHSVEGRRKALSTCGAHFtvVALFFVPCIFSYMRPST 261
Cdd:cd14972 153 L-PKSYLV-LILVFFFIALVIIVFLYVRIFWCLWRHanaiAARQEAAVPAQPSTSRKLAKT--VVIVLGVFLVCWLPLLI 228

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 47577249 262 TLSID-------KNMAVFYGILTPML-----NPLIYTLRNEEVKDAM 296
Cdd:cd14972 229 LLVLDvlcpsvcDIQAVFYYFLVLALlnsaiNPIIYAFRLKEMRRAV 275

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

31-147

7.33e-09

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 55.93 E-value: 7.33e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  31 VIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYE-GTTLSYEGCMAQLFGAHFLGGVE 109
Cdd:cd15005   9 LILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGsGWIYGALSCKVIAFLAVLFCFHS 88

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 47577249 110 IILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAW 147
Cdd:cd15005  89 AFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAW 126

7tmA_Peropsin

cd15073

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...

23-159

8.15e-09

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.

Pssm-ID: 320201 [Multi-domain] Cd Length: 280 Bit Score: 55.51 E-value: 8.15e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  23 RILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGA 102
Cdd:cd15073   1 NIVAAYLIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLN 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47577249 103 HFLGGVEIILLTVMAYDRYVAICKPLHYtTKMTRHLCVVLVGVAWLGGFLHSLVQIL 159
Cdd:cd15073  81 IFFGMASIGLLTVVAVDRYLTICRPDLG-RKMTTNTYTVMILLAWTNAFFWAAMPLV 136

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

24-295

5.04e-08

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 53.10 E-value: 5.04e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFL-VIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGA 102
Cdd:cd15064   1 VLISVLLsLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 103 HFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVqillifqlPFCG---PNVINhfvcdl 179
Cdd:cd15064  81 VTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLP--------PLFGwrtPDSED------ 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 180 ypllELACTDTYVIGLLVVANSGVICLLNFLMLgtsyivILHSLRYHSVEGRRKALSTCG---AHFTVVAL-FFVPCIFS 255
Cdd:cd15064 147 ----PSECLISQDIGYTIFSTFGAFYIPLLLML------ILYWKIYRAAARERKAAKTLGiilGAFIVCWLpFFLVALIV 216

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47577249 256 YMRPSTTLS-IDKNMAVFYGILTPMLNPLIYTLRNEEVKDA 295
Cdd:cd15064 217 PLCSHCWIPlALKSFFLWLGYFNSLINPLIYTFFNKDFRKA 257

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

27-224

9.87e-08

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 52.25 E-value: 9.87e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  27 VVFLVIYAVTVFGNMLIVVTITfSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFG----- 101
Cdd:cd14978   5 YVLPVICIFGIIGNILNLVVLT-RKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFLPyiypl 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 102 AHFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFVCDLYP 181
Cdd:cd14978  84 ANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTL 163

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 47577249 182 LLElacTDTYVIGLLVVANSGVICLLNFLMLGTSYIVILHSLR 224
Cdd:cd14978 164 LRQ---NETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALR 203

7tmA_GPR101

cd15215

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...

27-154

1.89e-07

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320343 [Multi-domain] Cd Length: 261 Bit Score: 51.38 E-value: 1.89e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  27 VVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLG 106
Cdd:cd15215   4 VLIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFA 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 47577249 107 GVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHS 154
Cdd:cd15215  84 FAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQS 131

7tmA_5-HT2B

cd15306

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...

30-301

2.36e-07

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341347 [Multi-domain] Cd Length: 277 Bit Score: 50.99 E-value: 2.36e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  30 LVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGT-TLSYEGCMAQLFGAHFLGGV 108
Cdd:cd15306   8 LMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMwPLPLVLCPIWLFLDVLFSTA 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 109 EIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWlggflhsLVQILLIFQLPFCGPNVINHFVCDLYPLLElacT 188
Cdd:cd15306  88 SIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVW-------LISIGIAIPVPIKGIETDVDNPNNITCVLT---K 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 189 DTYviGLLVVANSGVICLLNFLMLGTSYIVILHSLRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTTLSIDKN 268
Cdd:cd15306 158 ERF--GDFILFGSLAAFFTPLAIMIVTYFLTIHALRKQTITNEQRASKVLGIVFFLFLLMWCPFFITNITSVLCDSCNQT 235

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 47577249 269 MA-------VFYGILTPMLNPLIYTLRNEEVKDAMRKLFT 301
Cdd:cd15306 236 TLqmlmeifVWIGYVSSGVNPLVYTLFNKTFRDAFGRYIT 275

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

24-148

2.50e-07

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 51.29 E-value: 2.50e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAP----KLIADSLYEGTTLsyegCMAQL 99
Cdd:cd15317   2 IIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPfsmiRTVETCWYFGDLF----CKFHT 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47577249 100 FGAHFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWL 148
Cdd:cd15317  78 GLDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWL 126

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

28-164

2.54e-07

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 51.22 E-value: 2.54e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  28 VFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYS-SSLAPKLIADSLYEgTTLSYEGCMAQLFGAHFLG 106
Cdd:cd14986   6 VLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAfFTVLTQIIWEATGE-WVAGDVLCRIVKYLQVVGL 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 47577249 107 GVEIILLTVMAYDRYVAICKPLHYTTKMTRhlCVVLVGVAWLGGFLHSLVQiLLIFQL 164
Cdd:cd14986  85 FASTYILVSMSLDRYQAIVKPMSSLKPRKR--ARLMIVVAWVLSFLFSIPQ-LVIFVE 139

7tmA_5-HT2

cd15052

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...

24-295

2.95e-07

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320180 [Multi-domain] Cd Length: 262 Bit Score: 50.77 E-value: 2.95e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIyaVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGT-TLSYEGCMAQLFGA 102
Cdd:cd15052   4 ALLLLLLVI--ATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGGVwPLPLVLCLLWVTLD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 103 HFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPfcgPNVINHFVCDLYpl 182
Cdd:cd15052  82 VLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGIIDT---TNVLNNGTCVLF-- 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 183 lelacTDTYVIgllvvanSGVIC--LLNFLMLGTSYIVILHSLRyhsveGRRKALSTCGAHFTVVALFFVPCIFSYMRPS 260
Cdd:cd15052 157 -----NPNFVI-------YGSIVafFIPLLIMVVTYALTIRLLS-----NEQKASKVLGIVFAVFVICWCPFFITNILTG 219

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 47577249 261 TTLSIDKN-----MAVF--YGILTPMLNPLIYTLRNEEVKDA 295
Cdd:cd15052 220 LCEECNCRispwlLSVFvwLGYVSSTINPIIYTIFNKTFRRA 261

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

24-160

3.03e-07

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 50.70 E-value: 3.03e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLyegttlsyEGCMaqLFGAH 103
Cdd:cd15314   2 LLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSV--------ETCW--YFGDL 71

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47577249 104 F----------LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILL 160
Cdd:cd15314  72 FckihssfditLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFL 138

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

25-251

4.13e-07

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 50.34 E-value: 4.13e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  25 LFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHF 104
Cdd:cd14982   3 FPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLFYI 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 105 LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVqiLLIFQLPFCGPNviNHFVCDLYPLLE 184
Cdd:cd14982  83 NMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVP--LLLLRSTIAKEN--NSTTCFEFLSEW 158

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47577249 185 LACTDTYVIGLLVvansgVICLLNFLMLGTSYIVILHSLRYHSVEG-----RRKALSTCGAHFTVVALFFVP 251
Cdd:cd14982 159 LASAAPIVLIALV-----VGFLIPLLIILVCYSLIIRALRRRSKQSqksvrKRKALRMILIVLAVFLVCFLP 225

7tmA_MC2R_ACTH_R

cd15350

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...

27-147

7.08e-07

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320472 [Multi-domain] Cd Length: 270 Bit Score: 49.78 E-value: 7.08e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  27 VVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEG--------CMAQ 98
Cdd:cd15350   5 EVFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADMGYLNRRGpfetklddIMDS 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47577249  99 LFGAHFLGgvEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAW 147
Cdd:cd15350  85 LFCLSLLG--SIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIW 131

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

24-160

7.40e-07

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 49.66 E-value: 7.40e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEgttlsyegcmAQLFGAH 103
Cdd:cd15065   1 LIGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLG----------YWLFGET 70

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47577249 104 F----------LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILL 160
Cdd:cd15065  71 FcniwisfdvmCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIHL 137

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

24-155

8.58e-07

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 49.64 E-value: 8.58e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15083   2 VLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGG 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSL 155
Cdd:cd15083  82 LFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVL 133

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

30-159

9.95e-07

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 49.55 E-value: 9.95e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  30 LVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLyeGTTLSYEGCmaqLFGAHF---LG 106
Cdd:cd15069   8 LIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISL--GFCTDFHSC---LFLACFvlvLT 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 47577249 107 GVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQIL 159
Cdd:cd15069  83 QSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFL 135

7tmA_tyramine_R-like

cd15061

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

24-152

2.13e-06

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320189 [Multi-domain] Cd Length: 256 Bit Score: 48.13 E-value: 2.13e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15061   1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDV 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFL 152
Cdd:cd15061  81 LLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLL 129

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

24-152

2.18e-06

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 48.43 E-value: 2.18e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYA-VTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGA 102
Cdd:cd15074   1 IIIGIYLTVIGiLSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCG 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47577249 103 HFLGGVEIILLTVMAYDRYVAICKPlHYTTKMTRHLCVVLVGVAWLGGFL 152
Cdd:cd15074  81 FLFGCCSINTLTAISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALF 129

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

26-164

2.57e-06

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 48.19 E-value: 2.57e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  26 FVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYS-SSLAPKLIADSLYEGTTLSYeGCMAQLFGAHF 104
Cdd:cd15197   4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGlINVLTDIIWRITVEWRAGDF-ACKVIRYLQVV 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 105 LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRhlCVVLVGVAWLGGFLHSLvQILLIFQL 164
Cdd:cd15197  83 VTYASTYVLVALSIDRYDAICHPMNFSQSGRQ--ARVLICVAWILSALFSI-PMLIIFEK 139

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

24-155

2.97e-06

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 47.65 E-value: 2.97e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15329   2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDV 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSL 155
Cdd:cd15329  82 LLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISI 133

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

27-155

3.06e-06

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 47.67 E-value: 3.06e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  27 VVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFID-----TCYSSSLAPKLIADSLYEGTTLsyegCMAQLFG 101
Cdd:cd14997   5 VVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADllvllVCMPVALVETWAREPWLLGEFM----CKLVPFV 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 47577249 102 AHFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSL 155
Cdd:cd14997  81 ELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSS 134

7tmA_5-HT6

cd15054

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...

31-160

3.77e-06

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320182 [Multi-domain] Cd Length: 267 Bit Score: 47.49 E-value: 3.77e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  31 VIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGGVEI 110
Cdd:cd15054   9 LIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSASI 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47577249 111 ILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILL 160
Cdd:cd15054  89 LNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIEL 138

7tmA_Opsin_Gq_invertebrates

cd15337

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...

24-155

4.40e-06

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320459 [Multi-domain] Cd Length: 292 Bit Score: 47.32 E-value: 4.40e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVT-VFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYE-----GTTlsyeGCma 97
Cdd:cd15337   1 YLIGIYIAIVGILgVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNGFPLKTISSFNkkwiwGKV----AC-- 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47577249  98 QLFGahFLGGV----EIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSL 155
Cdd:cd15337  75 ELYG--FAGGIfgfmSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSI 134

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

24-148

4.50e-06

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 47.44 E-value: 4.50e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15012   1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWL 148
Cdd:cd15012  81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWL 125

7tmA_UII-R

cd14999

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...

27-161

6.70e-06

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.

Pssm-ID: 320130 [Multi-domain] Cd Length: 282 Bit Score: 46.67 E-value: 6.70e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  27 VVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLaPKLIADSLYEGTTLSYEGCMAqLFGAHFLG 106
Cdd:cd14999   4 TVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTI-PFYVSTYFLKKWYFGDVGCRL-LFSLDFLT 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47577249 107 -GVEIILLTVMAYDRYVAICKPLHyTTKMTRHLCVVLVGVAWLGGFLHSLVQILLI 161
Cdd:cd14999  82 mHASIFTLTVMSTERYLAVVKPLD-TVKRSKSYRKLLAGVIWLLSLLLTLPMAIMI 136

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

24-148

7.17e-06

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 46.82 E-value: 7.17e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAqlfgAH 103
Cdd:cd14993   2 VLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKA----VP 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47577249 104 FLGGV----EIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWL 148
Cdd:cd14993  78 YLQGVsvsaSVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWV 126

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

24-148

7.21e-06

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 46.58 E-value: 7.21e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLsYEGCMAQLFGA- 102
Cdd:cd15067   1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGYWL-FGRDWCDVWHSf 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 47577249 103 HFLGGVEIIL-LTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWL 148
Cdd:cd15067  80 DVLASTASILnLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWI 126

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

31-160

8.31e-06

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 46.68 E-value: 8.31e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  31 VIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGGVEI 110
Cdd:cd15058   9 LIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASI 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47577249 111 ILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILL 160
Cdd:cd15058  89 ETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFVPIMN 138

7tmA_GPR84-like

cd15210

G protein-coupled receptor 84 and similar proteins, member of the class A family of ...

27-161

1.03e-05

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.

Pssm-ID: 320338 [Multi-domain] Cd Length: 254 Bit Score: 46.10 E-value: 1.03e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  27 VVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPkLIADSLYEGT-TLSYEGCMAQLFGAHFL 105
Cdd:cd15210   5 VWGIVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLP-LAASTFLHQAwIHGETLCRVFPLLRYGL 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47577249 106 GGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLI 161
Cdd:cd15210  84 VAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLGI 139

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

24-155

1.21e-05

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 46.13 E-value: 1.21e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLaPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd14970   2 VIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGL-PFLATSYLLGYWPFGEVMCKIVLSVDA 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSL 155
Cdd:cd14970  81 YNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGL 132

7tmA_Parietopsin

cd15085

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...

36-148

1.24e-05

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.

Pssm-ID: 320213 [Multi-domain] Cd Length: 280 Bit Score: 46.00 E-value: 1.24e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  36 TVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGGVEIILLTV 115
Cdd:cd15085  14 SIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYFGIVSLWSLTL 93

                        90       100       110
                ....*....|....*....|....*....|...
gi 47577249 116 MAYDRYVAICKPLHyTTKMTRHLCVVLVGVAWL 148
Cdd:cd15085  94 LAYERYNVVCKPMG-GLKLSTKRGYQGLLFIWL 125

7tmA_D1-like_dopamine_R

cd15057

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...

110-160

1.59e-05

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320185 [Multi-domain] Cd Length: 299 Bit Score: 45.88 E-value: 1.59e-05

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 47577249 110 IILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILL 160
Cdd:cd15057  88 ILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVQL 138

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

35-148

2.17e-05

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 45.24 E-value: 2.17e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  35 VTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGGVEIILLT 114
Cdd:cd15318  13 IIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHLC 92

                        90       100       110
                ....*....|....*....|....*....|....
gi 47577249 115 VMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWL 148
Cdd:cd15318  93 FISIDRHCAICDPLLYPSKFTIRVACIFIAAGWL 126

7tmA_5-HT1A_vertebrates

cd15330

serotonin receptor subtype 1A from vertebrates, member of the class A family of ...

37-295

2.24e-05

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320453 [Multi-domain] Cd Length: 260 Bit Score: 44.97 E-value: 2.24e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  37 VFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGGVEIILLTVM 116
Cdd:cd15330  15 IFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAI 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 117 AYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSlVQILLIFQLP--FCGPNvinhfvcdlypllelACTDTYVIG 194
Cdd:cd15330  95 ALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSIS-IPPMLGWRTPedRSDPD---------------ACTISKDPG 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 195 LLVVANSGVICLLNFLMLgtsyivILHSLRYHSVEGRRKALST----------CGAHFTVVALFFVPCIFSYMRPSTTLS 264
Cdd:cd15330 159 YTIYSTFGAFYIPLILML------VLYGRIFKAAARERKTVKTlgiimgtfilCWLPFFIVALVLPFCESTCHMPELLGA 232

                       250       260       270
                ....*....|....*....|....*....|.
gi 47577249 265 IdknmAVFYGILTPMLNPLIYTLRNEEVKDA 295
Cdd:cd15330 233 I----INWLGYSNSLLNPIIYAYFNKDFQSA 259

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

24-152

2.29e-05

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 45.18 E-value: 2.29e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15063   2 ISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDV 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFL 152
Cdd:cd15063  82 WMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFV 130

7tmA_tyramine_octopamine_R-like

cd15060

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...

24-295

2.82e-05

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320188 [Multi-domain] Cd Length: 260 Bit Score: 44.73 E-value: 2.82e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15060   2 VTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGflhslvqiLLIFQLPFCGPNVINHFVCDLYPll 183
Cdd:cd15060  82 LCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALS--------ALISVPPLIGWNDWPENFTETTP-- 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 elaCTDTYVIGLLVVANSGVICLLNFLMlGTSYIVIlhslrYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYM-RP-ST 261
Cdd:cd15060 152 ---CTLTEEKGYVIYSSSGSFFIPLLIM-TIVYVKI-----FIATSKERRAARTLGIIMGVFVVCWLPFFLMYViLPfCE 222

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577249 262 TLSID---KNMAVFYGILTPMLNPLIYTLRNEEVKDA 295
Cdd:cd15060 223 TCSPSakvVNFITWLGYVNSALNPVIYTIFNLDFRRA 259

7tmA_mAChR_M3

cd15299

muscarinic acetylcholine receptor subtype M3, member of the class A family of ...

23-152

3.01e-05

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320426 [Multi-domain] Cd Length: 274 Bit Score: 44.55 E-value: 3.01e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  23 RILFVVFL--VIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLF 100
Cdd:cd15299   2 QVVLIAFLtgILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLS 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577249 101 GAHFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFL 152
Cdd:cd15299  82 IDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFV 133

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

28-147

3.22e-05

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 44.79 E-value: 3.22e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  28 VFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQ--------L 99
Cdd:cd15103   6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQhidnvidsM 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 47577249 100 FGAHFLGgvEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAW 147
Cdd:cd15103  86 ICSSLLA--SICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIW 131

7tmA_5-HT1B_1D

cd15333

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...

21-148

3.49e-05

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320455 [Multi-domain] Cd Length: 265 Bit Score: 44.40 E-value: 3.49e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  21 IQRILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLF 100
Cdd:cd15333   3 LKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLS 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 47577249 101 GAHFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWL 148
Cdd:cd15333  83 SDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWV 130

7tmA_mAChR_M1

cd17790

muscarinic acetylcholine receptor subtype M1, member of the class A family of ...

35-152

4.31e-05

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341356 [Multi-domain] Cd Length: 262 Bit Score: 44.19 E-value: 4.31e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  35 VTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSsLAPKLIADSLYEGT-TLSYEGCMAQLFGAHFLGGVEIILL 113
Cdd:cd17790  13 VTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGA-FSMNLYTTYILMGHwALGTVACDLWLALDYVASNASVMNL 91

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 47577249 114 TVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFL 152
Cdd:cd17790  92 LIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFV 130

7tmA_V1aR

cd15385

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

23-164

5.11e-05

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320507 [Multi-domain] Cd Length: 301 Bit Score: 44.04 E-value: 5.11e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  23 RILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSS-SLAPKLIADSLYEGTTLSYEGCMA---Q 98
Cdd:cd15385   1 KLEIAVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFfQVLPQLCWDITYRFYGPDFLCRIVkhlQ 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47577249  99 LFGAHflggVEIILLTVMAYDRYVAICKPLHYTTKMTRHlCVVLVGVAWLGGFLHSLVQiLLIFQL 164
Cdd:cd15385  81 VLGMF----ASTYMLVMMTADRYIAICHPLKTLQQPTKR-SYLMIGSAWALSFILSTPQ-YFIFSL 140

7tmA_PrRP_R

cd15394

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...

29-148

5.57e-05

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.

Pssm-ID: 320516 [Multi-domain] Cd Length: 286 Bit Score: 43.96 E-value: 5.57e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  29 FLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFID-----TCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15394   7 YSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDmlmcaTCVPLTLAYAFEPRGWVFGRFMCYFVFLMQPVTVY 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47577249 104 flggVEIILLTVMAYDRYVAICKPLHytTKMTRHLCVVLVGVAWL 148
Cdd:cd15394  87 ----VSVFTLTAIAVDRYYVTVYPLR--RRISRRTCAYIVAAIWL 125

7tmA_mAChR_M5

cd15300

muscarinic acetylcholine receptor subtype M5, member of the class A family of ...

28-152

5.69e-05

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320427 [Multi-domain] Cd Length: 262 Bit Score: 43.86 E-value: 5.69e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  28 VFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDT---CYSSSLAPKLIADSLYEGTTLSyegCMAQLFGAHF 104
Cdd:cd15300   6 VTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLiigIFSMNLYTSYILMGYWALGSLA---CDLWLALDYV 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 47577249 105 LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFL 152
Cdd:cd15300  83 ASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFI 130

7tmA_mAChR_DM1-like

cd15301

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...

24-147

6.67e-05

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320428 [Multi-domain] Cd Length: 270 Bit Score: 43.66 E-value: 6.67e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15301   2 LIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDY 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAW 147
Cdd:cd15301  82 LASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAW 125

7tmA_MC3R

cd15352

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...

28-148

7.23e-05

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320474 [Multi-domain] Cd Length: 272 Bit Score: 43.72 E-value: 7.23e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  28 VFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGG 107
Cdd:cd15352   6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHMDNVFDSM 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 47577249 108 VEIIL------LTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWL 148
Cdd:cd15352  86 ICISLvasicnLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWV 132

7tmA_5-HT2_insect-like

cd15307

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...

27-300

7.58e-05

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320433 [Multi-domain] Cd Length: 279 Bit Score: 43.40 E-value: 7.58e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  27 VVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLG 106
Cdd:cd15307   5 LLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFC 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 107 GVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPfcgPNVINHFVCDL-YPLLEL 185
Cdd:cd15307  85 TASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDH---ASVLVNGTCQIpDPVYKL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 186 actdtyvIGLLVVANSGVICLLNFLMLGTSYIVILHSLRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPSTTLSI 265
Cdd:cd15307 162 -------VGSIVCFYIPLGVMLLTYCLTVRLLARQRSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAEC 234

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 47577249 266 DK-------NMAVFYGILTPMLNPLIYTLRNEEVKDAMRKLF 300
Cdd:cd15307 235 EErishwvfDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVL 276

7tmA_GPR161

cd15214

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...

26-159

8.59e-05

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320342 [Multi-domain] Cd Length: 261 Bit Score: 43.39 E-value: 8.59e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  26 FVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFL 105
Cdd:cd15214   3 SIAIIIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLI 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 47577249 106 GGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWlggfLHSLVQIL 159
Cdd:cd15214  83 SSASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIW----LHSLIGCL 132

7tmA_alpha2B_AR

cd15321

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

27-148

9.46e-05

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320444 [Multi-domain] Cd Length: 268 Bit Score: 43.37 E-value: 9.46e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  27 VVFLVIYavTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLG 106
Cdd:cd15321  13 ITFLILF--TIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFC 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 47577249 107 GVEIILLTVMAYDRYVAICKPLHYTTKMT--RHLCVVLvgVAWL 148
Cdd:cd15321  91 TSSIVHLCAISLDRYWSVSRAIEYNSKRTprRIKCIIL--IVWL 132

7tmA_GPR26_GPR78-like

cd15219

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...

24-160

9.82e-05

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320347 [Multi-domain] Cd Length: 264 Bit Score: 43.22 E-value: 9.82e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMY-FFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGA 102
Cdd:cd15219   1 LLAVLLVVVLVVSLLSNLLVLLCFLYSAELRKQVPgIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLE 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 47577249 103 HFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILL 160
Cdd:cd15219  81 TFLTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFL 138

7tmA_alpha2C_AR

cd15323

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...

27-295

1.03e-04

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320446 [Multi-domain] Cd Length: 261 Bit Score: 43.00 E-value: 1.03e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  27 VVFLVIYavTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLG 106
Cdd:cd15323   7 VGFLIVF--TIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFC 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 107 GVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPfcgpnvinhfVCDLYPLLELA 186
Cdd:cd15323  85 TSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDP----------EGDVYPQCKLN 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 187 cTDTYVIGLLVVANSGVICLLNFLMlgtsYIVIlhslrYHSVEGRRKALSTCGAhftVVALFFVPCIFSYMRPSTTLSI- 265
Cdd:cd15323 155 -DETWYILSSCIGSFFAPCLIMILV----YIRI-----YRVAKAREKRFTFVLA---VVMGVFVVCWFPFFFSYSLYGIc 221

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577249 266 -------DKNMAVFY--GILTPMLNPLIYTLRNEEVKDA 295
Cdd:cd15323 222 reacevpEPLFKFFFwiGYCNSSLNPVIYTIFNQDFRRS 260

7tmA_S1PR

cd15102

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...

23-296

1.09e-04

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320230 [Multi-domain] Cd Length: 270 Bit Score: 42.84 E-value: 1.09e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  23 RILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDtcyssslapkLIADSLYEGTTL-----SYEGCMA 97
Cdd:cd15102   1 GATSVVFVAICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSD----------LLAGAAYLANILlsgarTLRLSPA 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  98 QLF---GAHFLG-GVEIILLTVMAYDRYVAICKP-LHYTTKMTRHLcvVLVGVAWLGGflhslvqiLLIFQLPFCGPNVI 172
Cdd:cd15102  71 QWFlreGSMFVAlSASVFSLLAIAIERHLTMAKMkPYGASKTSRVL--LLIGACWLIS--------LLLGGLPILGWNCL 140

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 173 NHF-----VCDLYPLLELACTDTYVIGLLVvansgVICLLnflmLGTSYIVILHSLRYHSVEGRRKALSTCGAHFTVVAL 247
Cdd:cd15102 141 GALdacstVLPLYSKHYVLFCVTIFAGILA-----AIVAL----YARIYCLVRASGRKATRASASPRSLALLKTVLIVLL 211

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 47577249 248 FFVPC--------IFSYMRPSTTLSIDKNMAVFYG--ILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15102 212 VFIACwgplfillLLDVACPVKTCPILYKADWFLAlaVLNSALNPIIYTLRSRELRRAV 270

7tmA_BRS-3

cd15123

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...

24-277

1.13e-04

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.

Pssm-ID: 320251 [Multi-domain] Cd Length: 294 Bit Score: 42.99 E-value: 1.13e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15123   2 AIYVTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHF-VCDLYPL 182
Cdd:cd15123  82 TSVGVSVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVFSDLYSFRDPEKNTTFeACAPYPV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 183 LELACTDTY-VIGLLV--VANSGVICLLNFLMLGTSYIVIL------HSLRYHSVEGRRKALSTCGAHFTVVALFFVPCI 253
Cdd:cd15123 162 SEKILQEIHsLLCFLVfyIIPLSIISVYYFLIARTLYKSTFnmpaeeHSHARKQIESRKRVAKTVLVLVALFAFCWLPNH 241

                       250       260
                ....*....|....*....|....
gi 47577249 254 FSYMRPSTTLSIDKNMAVFYGILT 277
Cdd:cd15123 242 ILYLYRSFTYHTSVDSSAFHLIAT 265

7tmA_AstC_insect

cd15094

somatostatin-like receptor for allatostatin C, member of the class A family of ...

24-173

1.26e-04

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.

Pssm-ID: 320222 [Multi-domain] Cd Length: 282 Bit Score: 42.85 E-value: 1.26e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLaPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15094   2 ISAVLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGL-PFLIVTMILKYWPFGAAMCKIYMVLTS 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVIN 173
Cdd:cd15094  81 INQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCT 150

7tmA_P2Y1-like

cd15168

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...

25-251

1.38e-04

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).

Pssm-ID: 341329 [Multi-domain] Cd Length: 284 Bit Score: 42.69 E-value: 1.38e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  25 LFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLaPKLIAdSLYEGTTLSY--EGCMAQLFGA 102
Cdd:cd15168   3 LPIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSL-PFLIY-YYANGDHWIFgdFMCKLVRFLF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 103 HFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLggflhsLVQILLIFQLPFCGPNVI-NHFVC-DLY 180
Cdd:cd15168  81 YFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWI------LVLLQLLPILFFATTGRKnNRTTCyDTT 154

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47577249 181 PLLELactDTYVIGLLVVANSGviCLLNFLMLGTSYIVILHSLRYHSVEG-----RRKALSTCGAHFTVVALFFVP 251
Cdd:cd15168 155 SPEEL---NDYVIYSMVLTGLG--FLLPLLIILACYGLIVRALIRKLGEGvtsalRRKSIRLVIIVLALFAVCFLP 225

7tmA_TAAR6_8_9

cd15316

trace amine-associated receptors 6, 8, and 9, member of the class A family of ...

24-148

1.59e-04

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320439 [Multi-domain] Cd Length: 290 Bit Score: 42.54 E-value: 1.59e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKliadslyeGTTLSYEGCMaqLFGAH 103
Cdd:cd15316   2 ILYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPF--------STVRSVESCW--YFGES 71

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47577249 104 F----------LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWL 148
Cdd:cd15316  72 FctfhtccdvsFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWI 126

7tmA_5-HT1F

cd15334

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...

24-297

1.60e-04

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320456 [Multi-domain] Cd Length: 259 Bit Score: 42.63 E-value: 1.60e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAV-TVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGA 102
Cdd:cd15334   1 ILISLTLSILALmTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 103 HFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVI---NHFVCDL 179
Cdd:cd15334  81 ITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFWRHQTTSREDECIikhDHIVFTI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 180 YPLLelactDTYVIGLLVvansgvicllnflmlgtsyIVILHSLRYHSVEGRRKALSTCG---AHFTVVAL-FFVPCIFS 255
Cdd:cd15334 161 YSTF-----GAFYIPLAL-------------------ILILYYKIYRAATRERKAATTLGlilGAFVICWLpFFVKEVIV 216

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 47577249 256 YMRPSTTLSID-KNMAVFYGILTPMLNPLIYTLRNEEVKDAMR 297
Cdd:cd15334 217 NTCDSCYISEEmSNFLTWLGYINSLINPLIYTIFNEDFKKAFQ 259

7tmA_MC4R

cd15353

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...

28-147

1.78e-04

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320475 [Multi-domain] Cd Length: 269 Bit Score: 42.20 E-value: 1.78e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  28 VFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTL---SYEGCMAQLFGAHF 104
Cdd:cd15353   6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLNGNDTdaqSFTVNIDNVIDSVI 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47577249 105 LGGV--EIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAW 147
Cdd:cd15353  86 CSSLlaSICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIW 130

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

24-159

1.88e-04

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 42.23 E-value: 1.88e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSlyEGTTLSYEGCmaqLFGAH 103
Cdd:cd15068   2 VYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS--TGFCAACHGC---LFIAC 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 47577249 104 F---LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQIL 159
Cdd:cd15068  77 FvlvLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPML 135

7tmA_GHSR-like

cd15928

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...

27-296

2.11e-04

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.

Pssm-ID: 320594 [Multi-domain] Cd Length: 288 Bit Score: 42.09 E-value: 2.11e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  27 VVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLG 106
Cdd:cd15928   5 AVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSETCT 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 107 GVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLhSLVQILLIFqlpfcGPNVINHFVcdlyPLLELA 186
Cdd:cd15928  85 YASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIV-SAGPALVLV-----GVEHIQGQQ----TPRGFE 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 187 CTDTYV-IGLLVVAN--SGVICLLNFLMLGtsyivILHSLRYHSVEGRRKALSTCGAH------------FTVVALFFVP 251
Cdd:cd15928 155 CTVVNVsSGLLSVMLwvSTSFFFVPMVCLS-----LLYGLIGRALWDRRQRSRTAGASrrdnnhrqtvrmLAVIVLAFVL 229

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47577249 252 C---------IFSYMRPSTTLSIDKNMAV-------FYgiLTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15928 230 CwlpfhvgrvIFNHSRASTKHLHYVSQYFnlvsfvlFY--LSAAINPILYNLMSKRYRYAV 288

7tmA_AT1R

cd15192

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...

27-285

2.16e-04

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.

Pssm-ID: 320320 [Multi-domain] Cd Length: 285 Bit Score: 42.03 E-value: 2.16e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  27 VVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLApkLIADSLYEGTTLSYEGCMAQLFGAHFLG 106
Cdd:cd15192   5 TVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLP--LWAAYTAMEYHWPFGNFLCKIASALVSF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 107 GV--EIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQIllIFQLPFCGPNViNHFVCDL-YPll 183
Cdd:cd15192  83 NLyaSVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAI--IHRDVFFIENT-NITVCAFhYP-- 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 elACTDTYVIGLLVVANSgVICLLNFLMLGTSYIVILHSLRyhSVEGRRKALSTCGAHFTV---VALFFVPC-----IFS 255
Cdd:cd15192 158 --SQNSTLLVGLGLMKNL-LGFLIPFLIILTCYTLIGKALK--KAYEIQRNKPRNDEIFKMimaVVLFFFFCwiphqIFT 232

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 47577249 256 YMRPSTTLSIDKNMAVFYGILTPM------------LNPLIY 285
Cdd:cd15192 233 FLDVLIQLKVIQDCHIADIVDTAMpfticiayfnscLNPILY 274

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

26-156

2.39e-04

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 41.86 E-value: 2.39e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  26 FVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLyeGTTLSYEGCmaqLFGAHF- 104
Cdd:cd14968   4 IVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISL--GLPTNFHGC---LFMACLv 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 47577249 105 --LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLV 156
Cdd:cd14968  79 lvLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLT 132

7tmA_DmOct-betaAR-like

cd15066

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...

28-160

3.16e-04

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.

Pssm-ID: 320194 [Multi-domain] Cd Length: 265 Bit Score: 41.59 E-value: 3.16e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  28 VFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDT-------CYSSSLApklIADSLYEGTTlsyegcMAQLF 100
Cdd:cd15066   5 AMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMlvalcamTFNASVE---ITGRWMFGYF------MCDVW 75

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47577249 101 GAH--FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILL 160
Cdd:cd15066  76 NSLdvYFSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLPIFL 137

7tmA_Glyco_hormone_R

cd15136

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...

25-159

3.20e-04

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.

Pssm-ID: 320264 [Multi-domain] Cd Length: 275 Bit Score: 41.43 E-value: 3.20e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  25 LFVVFLVIYAVTVFGNmLIVVTITFSSSLASPM-YFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYE-------GCM 96
Cdd:cd15136   3 LRIGVWFVFLLALVGN-IIVLLVLLTSRTKLTVpRFLMCNLAFADFCMGIYLGLLAIVDAKTLGEYYNYAidwqtgaGCK 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47577249  97 AQLFGAHFLGGVEIILLTVMAYDRYVAICKPLHYTTKMT-RHLCVVLVGvAWLGGFLHSLVQIL 159
Cdd:cd15136  82 TAGFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRLSlRQAAIIMLG-GWIFALIMALLPLV 144

7tmA_Histamine_H2R

cd15051

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...

24-160

3.75e-04

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320179 [Multi-domain] Cd Length: 287 Bit Score: 41.55 E-value: 3.75e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSslaspmyfflsNLSFIDTCYSSSLApklIADSLYEGTTLSYEGcMAQLFGAH 103
Cdd:cd15051   2 VLGVVLAVIILLTVIGNVLVCLAVAVNR-----------RLRNLTNYFIVSLA---VTDLLLGLLVLPFSA-IYELRGEW 66

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47577249 104 FLGGV---------------EIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILL 160
Cdd:cd15051  67 PLGPVfcniyisldvmlctaSILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIHL 138

7tmA_Parapinopsin

cd15075

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...

24-147

3.77e-04

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.

Pssm-ID: 320203 [Multi-domain] Cd Length: 279 Bit Score: 41.30 E-value: 3.77e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFID---TCYSSSLAPKLIADSLYegtTLSYEGCMAQLF 100
Cdd:cd15075   2 ILSIIMAVFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADlgtTVFGGLLSVVTNAVGYF---NLGRVGCVLEGF 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 47577249 101 GAHFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHlcvVLVGVAW 147
Cdd:cd15075  79 AVAFFGIAALCTVAVIAVDRLFVVCKPLGTLTFQTRH---ALAGIAS 122

7tmA_D1B_dopamine_R

cd15319

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...

110-160

3.84e-04

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320442 [Multi-domain] Cd Length: 317 Bit Score: 41.48 E-value: 3.84e-04

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 47577249 110 IILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILL 160
Cdd:cd15319  88 ILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPVQL 138

7tmA_V1bR

cd15386

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

28-164

4.48e-04

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320508 [Multi-domain] Cd Length: 302 Bit Score: 41.32 E-value: 4.48e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  28 VFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSS-SLAPKLIADSLY--EGTTLSyegCMAQLFGAHF 104
Cdd:cd15386   6 VLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALfQVLPQLIWEITYrfQGPDLL---CRAVKYLQVL 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 105 LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCvVLVGVAWLGGFLHSLVQIlLIFQL 164
Cdd:cd15386  83 SMFASTYMLIMMTVDRYIAVCHPLRTLQQPSRQAY-LMIGATWLLSCILSLPQV-FIFSL 140

7tmA_CCK-BR

cd15979

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...

27-152

5.11e-04

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320645 [Multi-domain] Cd Length: 275 Bit Score: 40.95 E-value: 5.11e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  27 VVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFID-----TCYSSSLAPKLIADSLYeGTTLsyegCMAQlfg 101
Cdd:cd15979   5 LLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDlmlavFCMPFTLIPNLMGTFIF-GEVI----CKAV--- 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 47577249 102 AHFLG---GVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFL 152
Cdd:cd15979  77 AYLMGvsvSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGL 130

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

30-295

5.58e-04

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 40.69 E-value: 5.58e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  30 LVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYE-GTTLSYEGCMAQLFGAHFLGGV 108
Cdd:cd15304   8 VIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGyRWPLPSKLCAVWIYLDVLFSTA 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 109 EIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWlggflhsLVQILLIFQLPFCGpnVINHfvCDLYPLLELACT 188
Cdd:cd15304  88 SIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVW-------TISVGISMPIPVFG--LQDD--SKVFKEGSCLLA 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 189 DTYviglLVVANSGVICLLNFLMLGTSYIVILHSLRyHSVEGRRKALSTCGAHFTVVALFFVP-CIFSYMRPSTTLSIDK 267
Cdd:cd15304 157 DEN----FVLIGSFVAFFIPLTIMVITYFLTIKSLQ-QSISNEQKASKVLGIVFFLFVVMWCPfFITNVMAVICKESCNE 231

                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577249 268 -------NMAVFYGILTPMLNPLIYTLRNEEVKDA 295
Cdd:cd15304 232 vviggllNVFVWIGYLSSAVNPLVYTLFNKTYRSA 266

7tmA_MC5R

cd15354

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...

28-147

7.93e-04

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320476 [Multi-domain] Cd Length: 270 Bit Score: 40.31 E-value: 7.93e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  28 VFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGG 107
Cdd:cd15354   6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRHIDNVFDSL 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47577249 108 VEIILLTVM------AYDRYVAICKPLHYTTKMTRHLCVVLVGVAW 147
Cdd:cd15354  86 ICISVVASMcsllaiAVDRYVTIFYALRYHNIMTVRRAGIIIACIW 131

7tmA_SREB3_GPR173

cd15217

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...

26-147

7.98e-04

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320345 [Multi-domain] Cd Length: 329 Bit Score: 40.70 E-value: 7.98e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  26 FVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIAdSLYEGTTLSYE-------GCMAQ 98
Cdd:cd15217   4 LVLLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLV-SIRNGSAWTYSvlsckivAFMAV 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47577249  99 LFGAHflggvEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAW 147
Cdd:cd15217  83 LFCFH-----AAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVW 126

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

24-295

8.19e-04

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 40.10 E-value: 8.19e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFL-VIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGA 102
Cdd:cd15050   1 APLGIALsTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 103 HFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHsLVQILLIFQLPFCGPNVINHFVCDlypl 182
Cdd:cd15050  81 YVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLW-VIPILGWHHFARGGERVVLEDKCE---- 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 183 lelacTDTYVIGLLVVansgVICLLNFlMLGTSYIVILHSLRYHSVEGRRKALSTCGAHFTVVALFFVPCIFSYMRPS-- 260
Cdd:cd15050 156 -----TDFHDVTWFKV----LTAILNF-YIPSLLMLWFYAKIFKAVNRERKAAKQLGFIMAAFILCWIPYFILFMVIAfc 225

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577249 261 -TTLSIDKNMA-VFYGILTPMLNPLIYTLRNEEVKDA 295
Cdd:cd15050 226 kNCCNENLHMFtIWLGYINSTLNPFIYPLCNENFKKT 262

7tmA_leucokinin-like

cd15393

leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...

24-155

1.02e-03

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.

Pssm-ID: 320515 [Multi-domain] Cd Length: 288 Bit Score: 40.08 E-value: 1.02e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15393   2 LLSILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQV 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLhyTTKMTRHLCVVLVGVAWLGGFLHSL 155
Cdd:cd15393  82 LSVNVSVFTLTVIAVDRYRAVIHPL--KARCSKKSAKIIILIIWILALLVAL 131

7tmA_Histamine_H3R_H4R

cd15048

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...

24-152

1.08e-03

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320176 [Multi-domain] Cd Length: 296 Bit Score: 39.98 E-value: 1.08e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15048   2 VLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDY 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFL 152
Cdd:cd15048  82 TLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFL 130

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

30-295

1.24e-03

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 39.89 E-value: 1.24e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  30 LVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYE-GTTLSYEGCMAQLFGAHFLGGV 108
Cdd:cd15305   8 LIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDyAWPLPRYLCPIWISLDVLFSTA 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 109 EIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWlggflhsLVQILLIFQLPFCG----PNVINHFVCDLYPlle 184
Cdd:cd15305  88 SIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVW-------TISIGISMPIPVIGlqddEKVFVNGTCVLND--- 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 185 lactdtyviGLLVVANSGVICLLNFLMLGTSYIVILHSL-RYHSVEGRRKALSTCGAHFTVVAL----FFVPCIFSYMRP 259
Cdd:cd15305 158 ---------ENFVLIGSFVAFFIPLIIMVITYCLTIQVLqRQQAINNERRASKVLGIVFFLFLImwcpFFITNILSVLCK 228

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 47577249 260 STT----LSIDKNMAVFYGILTPMLNPLIYTLRNEEVKDA 295
Cdd:cd15305 229 EACdqklMEELLNVFVWVGYVSSGINPLVYTLFNKTYRRA 268

7tmA_D1A_dopamine_R

cd15320

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...

110-160

1.29e-03

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320443 [Multi-domain] Cd Length: 319 Bit Score: 39.99 E-value: 1.29e-03

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 47577249 110 IILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILL 160
Cdd:cd15320  89 ILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFIPVQL 139

7tmA_alpha-2D_AR

cd15324

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

24-148

1.32e-03

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320447 [Multi-domain] Cd Length: 256 Bit Score: 39.47 E-value: 1.32e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAH 103
Cdd:cd15324   2 LIVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDV 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWL 148
Cdd:cd15324  82 LFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWV 126

7tmA_Chemokine_R

cd14984

classical and atypical chemokine receptors, member of the class A family of ...

27-250

1.34e-03

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.

Pssm-ID: 341319 [Multi-domain] Cd Length: 278 Bit Score: 39.51 E-value: 1.34e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  27 VVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLaPKLIADSLYE---GTTLsyegC--MAQLFG 101
Cdd:cd14984   5 VLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTL-PFWAVYAADGwvfGSFL----CklVSALYT 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 102 AHFLGGveIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQlpfcgPNVINHFVCdlYP 181
Cdd:cd14984  80 INFYSG--ILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQV-----SEENGSSIC--SY 150

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 47577249 182 LLELACTDTYVIGLLVVANSGVIcLLNFLMLGTSYIVILHSLRYHSVEGRRKALSTCgahFTVVALFFV 250
Cdd:cd14984 151 DYPEDTATTWKTLLRLLQNILGF-LLPLLVMLFCYSRIIRTLLRARNHKKHRALRVI---FAVVVVFFL 215

7tmA_Mel1

cd15209

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...

25-148

1.37e-03

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320337 [Multi-domain] Cd Length: 279 Bit Score: 39.76 E-value: 1.37e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  25 LFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLF--GA 102
Cdd:cd15209   3 LACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFimGL 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47577249 103 HFLGgvEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWL 148
Cdd:cd15209  83 SVIG--SIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWL 126

7tmA_MCHR-like

cd15088

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...

24-287

1.39e-03

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320216 [Multi-domain] Cd Length: 278 Bit Score: 39.74 E-value: 1.39e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSssLAPKLIADSLYEGTTLSYEGCMAQLFGA- 102
Cdd:cd15088   2 IMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFM--LGMPFLIHQFAIDGQWYFGEVMCKIITAl 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 103 ----HFLGgveIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILLIFQLPFCGPNVINHFvcD 178
Cdd:cd15088  80 dannQFTS---TYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTTFCYV--S 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 179 LYPLLELactDTYVIGLLVVAnsgviCLLNFLMLGTSYIVILHSLRYHSVEGR----RKALSTCGAHFTVVALFFVPCIF 254
Cdd:cd15088 155 LPSPDDL---YWFTIYHFILG-----FAVPLVVITVCYILILHRLARGVAPGNqshgSSRTKRVTKMVILIVVVFIVCWL 226

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 47577249 255 SYM----------RPSTTLSIDKNMAVFYGILTPMLNPLIYTL 287
Cdd:cd15088 227 PFHvvqlvnlamnRPTLAFEVAYFLSICLGYANSCLNPFVYIL 269

7tmA_mAChR_M2

cd15297

muscarinic acetylcholine receptor subtype M2, member of the class A family of ...

28-152

1.41e-03

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320424 [Multi-domain] Cd Length: 262 Bit Score: 39.56 E-value: 1.41e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  28 VFLVIYA-----VTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDtcysssLAPKLIADSLYEGTT------LSYEGCM 96
Cdd:cd15297   1 VFIVLVAgslslVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD------LIIGVFSMNLYTLYTvigywpLGPVVCD 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47577249  97 AQLFGAHFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFL 152
Cdd:cd15297  75 LWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFI 130

7tmA_Gal1_R

cd15098

galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...

24-234

1.73e-03

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320226 [Multi-domain] Cd Length: 282 Bit Score: 39.32 E-value: 1.73e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSL--ASPMYFFLSNLSFIDTCYssslapkLIADSLYEGTTLSYEGcmaQLFG 101
Cdd:cd15098   2 IVPVVFGLIFCLGVLGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFF-------LLFCVPFQATIYSLPE---WVFG 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 102 A------HFLGGV----EIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVqiLLIFQLPFCGPNV 171
Cdd:cd15098  72 AfmckfvHYFFTVsmlvSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASP--VAVHQDLVHHWTA 149

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47577249 172 INHFVC-DLYPllELACTDTYVIGLLVVANsgvicLLNFLMLGTSYIVILHSLRYHSVEGRRKA 234
Cdd:cd15098 150 SNQTFCwENWP--EKQQKPVYVVCTFVFGY-----LLPLLLITFCYAKVLNHLHKKLKNMSKKS 206

7tmA_CB2

cd15341

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...

34-296

1.97e-03

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320463 [Multi-domain] Cd Length: 279 Bit Score: 39.05 E-value: 1.97e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  34 AVTVFGNMLIVVTITFSSSL-ASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTlSYEGCMAQLFGAHFLGGVEIIL 112
Cdd:cd15341  12 LLCILENVAVLYLILSSPKLrRKPSYLFIGSLALADFLASVVFACSFVDFHVFHGVD-SSAIFLLKLGGVTMSFTASLGS 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 113 LTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWlggflhslVQILLIFQLPFCGPNV--INHFVCDLYPLLElactDT 190
Cdd:cd15341  91 LLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMW--------VLTALIAYLPLMGWNCcpLNSPCSELFPLIP----ND 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 191 YVigllvvanSGVICLLNFLMLGT--SYIVILHSLRYHSV--------EGRRKA--------LSTCGAHFTVVALFFVPC 252
Cdd:cd15341 159 YL--------LSWLLLVAILLSGIiyTYGHVLWKAHKHVVymekhqdqQGPGNArmrldvrlAKTLGLVLAVLLICWSPV 230

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 47577249 253 IFSYMRPSTTLSIDKNMAVF-----YGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15341 231 LALMMHSLFTSLSDHIKKAFafcstLCLVNSMVNPIIYALRSRELRSSL 279

7tmA_NPY2R

cd15399

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...

24-148

2.16e-03

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.

Pssm-ID: 320521 [Multi-domain] Cd Length: 285 Bit Score: 39.03 E-value: 2.16e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYE----GTTLSYEGCMAQL 99
Cdd:cd15399   2 VLILAYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDewkfGAVLCHLVPYAQA 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47577249 100 FGAHflggVEIILLTVMAYDRYVaiCKPLHYTTKMTRHLCVVLVGVAWL 148
Cdd:cd15399  82 LAVH----VSTVTLTVIALDRHR--CIVYHLESKISKKISFLIIGLTWA 124

7tmA_Pinopsin

cd15084

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...

30-128

2.22e-03

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320212 [Multi-domain] Cd Length: 295 Bit Score: 39.08 E-value: 2.22e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  30 LVIYAVTVFGNMLIVVTITFSSsLASPMYFFLSNLSFID---TCYSSSLApklIADSLYEGTTLSYEGCMAQLFGAHFLG 106
Cdd:cd15084  19 MVVALASFVNGLVIVVSIKYKK-LRSPLNYILVNLAVADllvTLFGSSVS---FSNNIVGFFVFGKTMCEFEGFMVSLTG 94

                        90       100
                ....*....|....*....|..
gi 47577249 107 GVEIILLTVMAYDRYVAICKPL 128
Cdd:cd15084  95 IVGLWSLAILAFERYLVICKPM 116

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

24-155

2.58e-03

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 38.88 E-value: 2.58e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  24 ILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCY-----------SSSLAPKLIADSLYEGTTLSY 92
Cdd:cd14979   2 LVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLIllvglpvelynFWWQYPWAFGDGGCKLYYFLF 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47577249  93 EGCMAqlfgahflggVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSL 155
Cdd:cd14979  82 EACTY----------ATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAI 134

7tmA_Angiotensin_R-like

cd14985

angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...

23-250

2.63e-03

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.

Pssm-ID: 341320 [Multi-domain] Cd Length: 284 Bit Score: 38.90 E-value: 2.63e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  23 RILFVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLApkLIADSLYEGTTLSYEGCMAQLFGA 102
Cdd:cd14985   1 VVIPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLP--LWATYTANQYDWPFGAFLCKVSSY 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 103 HFLGG--VEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQILL--IFQLPFCGPNvinhfVCD 178
Cdd:cd14985  79 VISVNmfASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLrsLQAIENLNKT-----ACI 153

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47577249 179 LYPLLElactdTYVIGLLVVANSgVICLLNFLMLGTSYIVILHSLR---YHSVEGRRKALSTCGAHFTVVALFFV 250
Cdd:cd14985 154 MLYPHE-----AWHFGLSLELNI-LGFVLPLLIILTCYFHIARSLRkryERTGKNGRKRRKSLKIIFALVVAFLV 222

7tmA_MC1R

cd15351

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...

28-158

3.90e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320473 [Multi-domain] Cd Length: 271 Bit Score: 38.24 E-value: 3.90e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  28 VFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQlfgaHFLGG 107
Cdd:cd15351   6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQ----HMDNV 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47577249 108 VEIIL----------LTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQI 158
Cdd:cd15351  82 IDTMIcssvvsslsfLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFI 142

7tmA_VA_opsin

cd15082

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...

23-128

4.00e-03

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320210 [Multi-domain] Cd Length: 291 Bit Score: 38.24 E-value: 4.00e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  23 RILFVVFLVIYAVTVFGNML-IVVTITFSSsLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFG 101
Cdd:cd15082  14 TVLAALMFVVTSLSLAENFAvMLVTFRFKQ-LRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVWACVLEGFA 92

                        90       100
                ....*....|....*....|....*..
gi 47577249 102 AHFLGGVEIILLTVMAYDRYVAICKPL 128
Cdd:cd15082  93 VTFFGIVALWSLAVLAFERFFVICRPL 119

7tmA_Cannabinoid_R

cd15099

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...

35-296

5.10e-03

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320227 [Multi-domain] Cd Length: 281 Bit Score: 37.89 E-value: 5.10e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  35 VTVFGNMLIVVTITFSSSL-ASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTlSYEGCMAQLFG--AHFLGGVEII 111
Cdd:cd15099  13 VTFLENILVLLTILSSTALrRRPSYLFIGSLALADMLASVIFTISFLDFHVFHQRD-SRNLFLFKLGGvtMAFTASVGSL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 112 LLTvmAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWlggflhsLVQILLIFqLPFCGPNV--INHFVCDLYPLLElactD 189
Cdd:cd15099  92 LLT--ALDRYLCIYQPSNYKLLVTRTRAKVAILLMW-------CVTIIISF-LPLMGWRCktWDSPCSRLFPYID----R 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 190 TYVIGLLVVansgVICLLNFLMLGTSYIV----------ILHSLRYHSVEGRRKA------LSTCGAHFTVVALFFVPcI 253
Cdd:cd15099 158 HYLASWTGL----QLVLLFLIIYAYPYILwkahrheanmGGPKLGRQQVKGQARMrmdirlAKTLSLILLVLAICWLP-V 232

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 47577249 254 FSYMRPSTTLSIDKNMAVFYG------ILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15099 233 LAFMLVDVRVTLTNKQKRMFAfcsmlcLVNSCVNPIIYALRSRELRGAM 281

7tmA_OT_R

cd15387

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

28-171

5.20e-03

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320509 [Multi-domain] Cd Length: 297 Bit Score: 37.87 E-value: 5.20e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  28 VFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSS-SLAPKLIADSLYegttlsyegcmaQLFGAHFLG 106
Cdd:cd15387   6 VLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfQVLPQLIWDITF------------RFYGPDFLC 73

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 47577249 107 GV-----------EIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVlvgVAWLGGFLHSLVQIlLIFQLPFCGPNV 171
Cdd:cd15387  74 RLvkylqvvgmfaSTYMLLLMSIDRCLAICQPLRSLHRRSDRVYVL---FSWLLSLVFSIPQV-HIFSLREVGNGV 145

7tmA_GPR19

cd15008

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...

27-148

5.75e-03

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320137 [Multi-domain] Cd Length: 275 Bit Score: 37.89 E-value: 5.75e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  27 VVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLG 106
Cdd:cd15008   4 LVFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTP 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 47577249 107 GVEIILLTVMAYDRYVAICKPLHYttKMTRHLCVVLVGVAWL 148
Cdd:cd15008  84 GVQIYVLLSICVDRFYTIVYPLSF--KVSREKAKKMIAASWL 123

7tmA_NPR-like_invertebrate

cd15391

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...

33-158

5.75e-03

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.

Pssm-ID: 320513 [Multi-domain] Cd Length: 289 Bit Score: 37.88 E-value: 5.75e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  33 YAVTVF----GNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGGV 108
Cdd:cd15391   7 YQSTIFlsvgGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTA 86

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47577249 109 EIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLvgVAWLGGFLHSLVQI 158
Cdd:cd15391  87 SVLTNTAIGIDRFFAVIFPLRSRHTKSRTKCIIA--SIWAISFSLSSVQL 134

PHA03087

G protein-coupled chemokine receptor-like protein; Provisional

24-148

5.82e-03

G protein-coupled chemokine receptor-like protein; Provisional

Pssm-ID: 222976 [Multi-domain] Cd Length: 335 Bit Score: 37.84 E-value: 5.82e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249   24 ILFVVFLVIYAVTVFGNMlIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLaPKLIADSLYEGTTLSYEGC--MAQLFG 101
Cdd:PHA03087  42 ILIVVYSTIFFFGLVGNI-IVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTL-PFQIYYYILFQWSFGEFACkiVSGLYY 119

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 47577249  102 AHFLggVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWL 148
Cdd:PHA03087 120 IGFY--NSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWI 164

7tmA_SREB2_GPR85

cd15218

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...

32-147

6.10e-03

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320346 [Multi-domain] Cd Length: 330 Bit Score: 37.70 E-value: 6.10e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  32 IYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPkLIADSLYEGTTLSYEGCMAQLFGahFLGGVEI- 110
Cdd:cd15218  10 IIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFP-FVFTSVKNGSTWTYGTLTCKVIA--FLGVLSCf 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 47577249 111 ---ILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAW 147
Cdd:cd15218  87 htaFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVW 126

7tmA_S1PR2_Edg5

cd15347

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...

27-300

6.15e-03

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320469 [Multi-domain] Cd Length: 266 Bit Score: 37.48 E-value: 6.15e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  27 VVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSlapkLIADSLYEGT---TLSYEGCMAQLFGAH 103
Cdd:cd15347   5 IFIVILCCIIVLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGVA----FIANILLSGSvtfRLTPVQWFIREGTAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 104 FLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLcVVLVGVAWlggflhslVQILLIFQLPFCGPNVINHFVcDLYPLL 183
Cdd:cd15347  81 ITLSASVFSLLAIAIERHVAITKVKLYGSDKNCRM-VLLIGACW--------VISIVLGGLPILGWNCIGNLE-DCSTVL 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 184 ELAcTDTYVigLLVVANSGVICLLNFLMLGTSYIVILHSlryHSVEGRRKALSTCGAHFTVVALF-------FVPCIFSY 256
Cdd:cd15347 151 PLY-SKHYI--LFVVTIFSIILLSIVILYVRIYCIVRSS---HAEMAAPQTLALLKTVTIVLGVFivcwlpaFIILLLDT 224

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 47577249 257 MRPSTTLSIDKNMAVFYGI--LTPMLNPLIYTLRNEEvkdaMRKLF 300
Cdd:cd15347 225 SCKVKSCPILYKADYFFSVatLNSALNPVIYTLRSKD----MRKEF 266

7tmA_BNGR-A34-like

cd15000

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...

28-296

6.39e-03

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320131 [Multi-domain] Cd Length: 285 Bit Score: 37.79 E-value: 6.39e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  28 VFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGG 107
Cdd:cd15000   5 MFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 108 VEIILLTVMAYDRYVAICKPLHytTKMTRHLCVVLVGVAWLGGFLHSL---------VQILLIFQLPFCGPNVInhfVCD 178
Cdd:cd15000  85 ASVLALCAVSYDRLTAIVLPSE--ARLTKRGAKIVIVITWIVGLLLALplaiyrsyrERQWKNFLETYCAENTQ---VLP 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 179 LYPLLelactdtyVIGLLVVANSGV--ICLLN-FLMLGTSYIVILHSLRYHSVEGRRKALSTcgahFTVVALFFVPC--- 252
Cdd:cd15000 160 IYWHV--------IITVLVWLPLGImlICYSAiFWKLDKYERRVLRREHPSVVRYKKKAAKT----LFIVLITFVVCrip 227

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 47577249 253 -----IFSYMRP---STTLSIDKNM------AVFYGILTPMLNPLIYTLRNEEVKDAM 296
Cdd:cd15000 228 ftaliFYRYKLVpndNTQNSVSGSFhilwfaSKYLMFLNAAVNPLIYGFTNENFRKAF 285

7tmA_GPR25

cd15193

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...

27-152

6.73e-03

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.

Pssm-ID: 320321 [Multi-domain] Cd Length: 279 Bit Score: 37.42 E-value: 6.73e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  27 VVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLG 106
Cdd:cd15193   5 ILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFIIAVNR 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47577249 107 GVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFL 152
Cdd:cd15193  85 CSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLV 130

7tmA_alpha2A_AR

cd15322

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

36-148

6.87e-03

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320445 [Multi-domain] Cd Length: 259 Bit Score: 37.62 E-value: 6.87e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  36 TVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFLGGVEIILLTV 115
Cdd:cd15322  14 TVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCA 93

                        90       100       110
                ....*....|....*....|....*....|...
gi 47577249 116 MAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWL 148
Cdd:cd15322  94 ISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWV 126

7tmA_Adenosine_R_A1

cd15071

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...

31-159

7.42e-03

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.

Pssm-ID: 341323 [Multi-domain] Cd Length: 290 Bit Score: 37.52 E-value: 7.42e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  31 VIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLyeGTTLSYEGCMAQLFGAHFLGGVEI 110
Cdd:cd15071   9 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINI--GPQTEFYSCLMVACPVLILTQSSI 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47577249 111 ILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQIL 159
Cdd:cd15071  87 LALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMF 135

7tmA_FP

cd15145

prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G ...

95-159

8.11e-03

prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The PGF2-alpha receptor, also called prostanoid FP receptor, is a class A G-protein coupled receptor whose endogenous ligand is prostaglandin F2-alpha. PGF2-alpha binding to this receptor is coupled to the stimulation of phospholipase C (PLC) pathway via G-protein subunit G(q). This leads to the release of inositol trisphosphate (IP3) and diacylglycerol (DAG) which results in increased intracellular Ca2+ levels and activation of PKC. The receptor activation primarily induces uterine contraction and bronchoconstriction, and stimulates luteolysis. Like most prostanoid receptors, the PGF2-alpha receptor has also been implicated in tumor angiogenesis and metastasis.

Pssm-ID: 320273 [Multi-domain] Cd Length: 290 Bit Score: 37.49 E-value: 8.11e-03

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47577249  95 CMAqlfgahFLGGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQIL 159
Cdd:cd15145  88 CMV------FFGLCPLLLGSVMAVERCIGVTKPIFHSTKMTSKHVKMMLSGVCLFAVLVALLPIL 146

7tmA_CCR10

cd15177

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...

28-159

8.24e-03

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.

Pssm-ID: 341332 [Multi-domain] Cd Length: 280 Bit Score: 37.45 E-value: 8.24e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  28 VFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLaPKLIADSLyEGTTLSYEGCMA--QLFGAHFL 105
Cdd:cd15177   6 VYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTL-PFAAAETL-QGWIFGNAMCKLiqGLYAINFY 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47577249 106 GGveIILLTVMAYDRYVAICK--PLHYTTKMTRHLCVVLVGVAWLGGFLHSLVQIL 159
Cdd:cd15177  84 SG--FLFLTCISVDRYVVIVRatSAHRLRPKTLFYSVLTSLIVWLLSILFALPQLI 137

7tmA_GnRHR-like

cd15195

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...

28-285

8.78e-03

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320323 [Multi-domain] Cd Length: 293 Bit Score: 37.38 E-value: 8.78e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  28 VFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPkliADSLYEGTTLSYEG---CMAQLFGAHF 104
Cdd:cd15195   6 VTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMP---MDAVWNYTVEWLAGdlmCRVMMFLKQF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 105 LGGVEIILLTVMAYDRYVAICKPLHYTTKMTRhlCVVLVGVAWLGGFLHSLVQiLLIFQLPFCGPNVINHFVC------- 177
Cdd:cd15195  83 GMYLSSFMLVVIALDRVFAILSPLSANQARKR--VKIMLTVAWVLSALCSIPQ-SFIFSVLRKMPEQPGFHQCvdfgsap 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249 178 -----DLYPLLELACtdTYVIGLL--VVANSGVICLLNFLMLGT--SYIVILHSLRYHSVEGRRKALSTCGAhfTVVALF 248
Cdd:cd15195 160 tkkqeRLYYFFTMIL--SFVIPLIitVTCYLLILFEISKMAKRArdTPISNRRRSRTNSLERARMRTLRMTA--LIVLTF 235

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 47577249 249 FV-------PCIFSYMRPSTTLSIDKNMAVF---YGILTPMLNPLIY 285
Cdd:cd15195 236 IVcwgpyyvLGLWYWFDKESIKNLPPALSHImflLGYLNPCLHPIIY 282

7tmA_TACR

cd15390

neurokinin receptors (or tachykinin receptors), member of the class A family of ...

26-159

9.09e-03

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320512 [Multi-domain] Cd Length: 289 Bit Score: 37.27 E-value: 9.09e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  26 FVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFL 105
Cdd:cd15390   4 SIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITT 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 47577249 106 GGVEIILLTVMAYDRYVAICKPLHytTKMTRHLCVVLVGVAWLGGFLHSLVQIL 159
Cdd:cd15390  84 VAASVFTLMAISIDRYIAIVHPLR--PRLSRRTTKIAIAVIWLASFLLALPQLL 135

7tmA_GPRnna14-like

cd15001

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...

26-152

9.97e-03

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320132 [Multi-domain] Cd Length: 266 Bit Score: 36.87 E-value: 9.97e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577249  26 FVVFLVIYAVTVFGNMLIVVTITFSSSLASPMYFFLSNLSFIDTCYSSSLAPKLIADSLYEGTTLSYEGCMAQLFGAHFL 105
Cdd:cd15001   3 IIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLS 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 47577249 106 GGVEIILLTVMAYDRYVAICKPLHYTTKMTRHLCVVLVGVAWLGGFL 152
Cdd:cd15001  83 FICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAI 129

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01