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Conserved domains on  [gi|47577609|ref|NP_001000564|]
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olfactory receptor Olr536 [Rattus norvegicus]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11607545)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
25-302 8.95e-155

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 434.05  E-value: 8.95e-155
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15411   1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPY-INHFFCDTTAL 183
Cdd:cd15411  81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNvINHFFCDTPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDN 263
Cdd:cd15411 161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577609 264 TSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLR 302
Cdd:cd15411 241 SYSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
 
Name Accession Description Interval E-value
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
25-302 8.95e-155

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 434.05  E-value: 8.95e-155
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15411   1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPY-INHFFCDTTAL 183
Cdd:cd15411  81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNvINHFFCDTPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDN 263
Cdd:cd15411 161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577609 264 TSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLR 302
Cdd:cd15411 241 SYSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
31-304 4.69e-38

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 136.09  E-value: 4.69e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609    31 FLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGLVCS 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609   111 ECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLC-DPYINHFFCDTTALLALSCV 189
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCgHHVLSHSYCLHMGLARLSCA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609   190 D-AFNTELVIFVLAGFTLLSSLLIItFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQ---PDNTS 265
Cdd:pfam13853 161 DiKVNNIYGLFVVTSTFGIDSLLIV-LSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVhrfGHNVP 239
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 47577609   266 SLTQAQVASVfYTIVIPMLNPLIYSLRNKDVKNALLRVI 304
Cdd:pfam13853 240 PLLQIMMANA-YLFFPPVLNPIVYSVKTKQIRDCVKRML 277
 
Name Accession Description Interval E-value
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
25-302 8.95e-155

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 434.05  E-value: 8.95e-155
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15411   1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPY-INHFFCDTTAL 183
Cdd:cd15411  81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNvINHFFCDTPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDN 263
Cdd:cd15411 161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577609 264 TSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLR 302
Cdd:cd15411 241 SYSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
27-293 5.75e-143

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 403.43  E-value: 5.75e-143
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15230   3 LFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPY-INHFFCDTTALLA 185
Cdd:cd15230  83 FGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNvINHFFCDIPPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15230 163 LSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSY 242
                       250       260
                ....*....|....*....|....*...
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15230 243 SLDQDKVVSVFYTVVIPMLNPLIYSLRN 270
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
12-304 1.72e-132

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 378.15  E-value: 1.72e-132
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  12 FMLSGFSDHPELQVSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKS 91
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  92 ISFVGCFVQMYFFVGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP 171
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 172 -YINHFFCDTTALLALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVF 250
Cdd:cd15410 161 nVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 47577609 251 YGSLIFTYLQPDNTSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLRVI 304
Cdd:cd15410 241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
12-304 1.12e-131

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 375.93  E-value: 1.12e-131
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  12 FMLSGFSDHPELQVSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKS 91
Cdd:cd15943   2 FILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  92 ISFVGCFVQMYFFVGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP 171
Cdd:cd15943  82 ISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 172 -YINHFFCDTTALLALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVF 250
Cdd:cd15943 162 nVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIF 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 47577609 251 YGSLIFTYLQPDNTSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLRVI 304
Cdd:cd15943 242 YGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
12-297 7.30e-131

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 373.58  E-value: 7.30e-131
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  12 FMLSGFSDHPELQVSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKS 91
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  92 ISFVGCFVQMYFFVGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP 171
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 172 Y-INHFFCDTTALLALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVF 250
Cdd:cd15408 161 NvINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 47577609 251 YGSLIFTYLQPDNTSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVK 297
Cdd:cd15408 241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
25-293 2.44e-129

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 369.12  E-value: 2.44e-129
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd13954   1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTAL 183
Cdd:cd13954  81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSnVINHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDN 263
Cdd:cd13954 161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 47577609 264 TSSLTQAQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd13954 241 SYSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
27-300 6.15e-128

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 365.62  E-value: 6.15e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15225   3 LFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPY-INHFFCDTTALLA 185
Cdd:cd15225  83 LGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNeINHFFCDIPPVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15225 163 LACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSY 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15225 243 SPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
25-302 3.03e-126

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 361.58  E-value: 3.03e-126
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15417   1 IILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPY-INHFFCDTTAL 183
Cdd:cd15417  81 SGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNvIDHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDN 263
Cdd:cd15417 161 LSLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577609 264 TSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLR 302
Cdd:cd15417 241 SHSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
27-302 1.53e-123

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 354.78  E-value: 1.53e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15412   3 LFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTALLA 185
Cdd:cd15412  83 LVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSnVINHFYCADPPLIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15412 163 LSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEE 242
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLR 302
Cdd:cd15412 243 SVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
16-304 4.96e-123

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 353.98  E-value: 4.96e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  16 GFSDHPELQVSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFV 95
Cdd:cd15406   1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  96 GCFVQMYFFVGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLC-DPYIN 174
Cdd:cd15406  81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCgDNVIN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 175 HFFCDTTALLALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSL 254
Cdd:cd15406 161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 47577609 255 IFTYLQPDNTSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLRVI 304
Cdd:cd15406 241 IFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
25-302 1.78e-122

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 352.01  E-value: 1.78e-122
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15413   1 IPLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTAL 183
Cdd:cd15413  81 LTFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSnVINHFYCDDLPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDN 263
Cdd:cd15413 161 LALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577609 264 TSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLR 302
Cdd:cd15413 241 SHSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
25-302 5.75e-118

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 340.83  E-value: 5.75e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15419   1 VLLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPY-INHFFCDTTAL 183
Cdd:cd15419  81 SLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNeIDHFFCDVPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDN 263
Cdd:cd15419 161 LKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGA 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577609 264 TSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLR 302
Cdd:cd15419 241 VSSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
25-307 1.20e-117

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 340.17  E-value: 1.20e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15414   1 IPLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTAL 183
Cdd:cd15414  81 GLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPnVINHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDN 263
Cdd:cd15414 161 LSLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSS 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 47577609 264 TSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLRVIDRK 307
Cdd:cd15414 241 SSSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRRK 284
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
12-302 2.99e-115

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 334.41  E-value: 2.99e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  12 FMLSGFSDHPELQVSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKS 91
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  92 ISFVGCFVQMYFFVGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLC-D 170
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCgS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 171 PYINHFFCDTTALLALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVF 250
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577609 251 YGSLIFTYLQPDNTSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLR 302
Cdd:cd15945 241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
27-293 3.83e-113

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 328.08  E-value: 3.83e-113
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15237   3 LFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTALLA 185
Cdd:cd15237  83 LGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPnHINHFFCEAPAVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15237 163 LACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTH 242
                       250       260
                ....*....|....*....|....*...
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15237 243 SPDQDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
27-293 1.74e-112

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 326.36  E-value: 1.74e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15911   3 LFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPY-INHFFCDTTALLA 185
Cdd:cd15911  83 LAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNeIDHFFCDFAPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15911 163 LSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNT 242
                       250       260
                ....*....|....*....|....*...
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15911 243 SRDLNKVFSLFYTVLTPLVNPLIYSLRN 270
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
25-302 3.82e-112

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 325.86  E-value: 3.82e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15416   1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTAL 183
Cdd:cd15416  81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPnEINHFFCDFPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDN 263
Cdd:cd15416 161 LKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577609 264 TSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLR 302
Cdd:cd15416 241 SYSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
27-300 4.29e-112

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 325.71  E-value: 4.29e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15229   3 LFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTALLA 185
Cdd:cd15229  83 FAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPnEINHFSCELPSLLP 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15229 163 LSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSAS 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15229 243 SSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
25-300 3.36e-111

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 323.45  E-value: 3.36e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15231   1 LLLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTAL 183
Cdd:cd15231  81 VSFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSnQISHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDN 263
Cdd:cd15231 161 LKLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577609 264 TSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15231 241 GYSLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
25-302 5.51e-111

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 322.82  E-value: 5.51e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15409   1 VPLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTAL 183
Cdd:cd15409  81 GFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSnEINHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDN 263
Cdd:cd15409 161 LKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577609 264 TSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLR 302
Cdd:cd15409 241 LYALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
25-302 1.42e-110

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 322.06  E-value: 1.42e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15415   1 VPLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTAL 183
Cdd:cd15415  81 AVFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPnVINHYFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDN 263
Cdd:cd15415 161 LKLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577609 264 TSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLR 302
Cdd:cd15415 241 QYSLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
24-300 4.41e-110

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 320.71  E-value: 4.41e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  24 QVSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYF 103
Cdd:cd15235   1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 104 FVGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLC-DPYINHFFCDTTA 182
Cdd:cd15235  81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCgSNEIPHFFCDLQP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 183 LLALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPD 262
Cdd:cd15235 161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47577609 263 NTSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15235 241 SSYSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
25-293 1.01e-108

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 316.73  E-value: 1.01e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15912   1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPY-INHFFCDTTAL 183
Cdd:cd15912  81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNvINHFFCDSGPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDN 263
Cdd:cd15912 161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240
                       250       260       270
                ....*....|....*....|....*....|
gi 47577609 264 TSSLTQAQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15912 241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
27-300 1.21e-108

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 316.80  E-value: 1.21e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15421   3 LFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPY-INHFFCDTTALLA 185
Cdd:cd15421  83 LGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSReIHHFFCEVPALLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15421 163 LSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYH 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15421 243 SPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
25-302 3.00e-107

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 313.59  E-value: 3.00e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15407   1 IPLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTAL 183
Cdd:cd15407  81 VVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSnVINHFFCDIPPV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDN 263
Cdd:cd15407 161 LALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577609 264 TSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLR 302
Cdd:cd15407 241 SHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
25-293 3.63e-106

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 310.31  E-value: 3.63e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15431   1 IILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVIsSLPLCDPY-INHFFCDTTAL 183
Cdd:cd15431  81 LFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLTM-PLHFCGPNvINHFFCEVQAL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDN 263
Cdd:cd15431 160 LKLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQS 239
                       250       260       270
                ....*....|....*....|....*....|
gi 47577609 264 TSSLTQAQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15431 240 KSSSDQDKIISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
12-304 7.49e-106

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 310.56  E-value: 7.49e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  12 FMLSGFSDHPELQVSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKS 91
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  92 ISFVGCFVQMYFFVGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLC-D 170
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCgS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 171 PYINHFFCDTTALLALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVF 250
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 47577609 251 YGSLIFTYLQPDNTSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLRVI 304
Cdd:cd15944 241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
25-293 1.51e-105

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 308.83  E-value: 1.51e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15224   1 LLLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTAL 183
Cdd:cd15224  81 LSLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPnVINHFFCDISPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDN 263
Cdd:cd15224 161 LNLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKA 240
                       250       260       270
                ....*....|....*....|....*....|
gi 47577609 264 TSSLTQAQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15224 241 ISSFDSNKLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
27-293 9.58e-103

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 301.84  E-value: 9.58e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15918   3 LFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLC-DPYINHFFCDTTALLA 185
Cdd:cd15918  83 FGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCaSNEIPHFFCDLNPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15918 163 LSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSH 242
                       250       260
                ....*....|....*....|....*...
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15918 243 SASKDSVAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
25-300 5.18e-102

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 300.09  E-value: 5.18e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15429   1 LGLFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLC-DPYINHFFCDTTAL 183
Cdd:cd15429  81 LALGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCgHNTINHFSCELLAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDN 263
Cdd:cd15429 161 VRLACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577609 264 TSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15429 241 GSSALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
27-293 5.50e-99

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 292.22  E-value: 5.50e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15947   3 LFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLW 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPY-INHFFCDTTALLA 185
Cdd:cd15947  83 LGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHtLDHFFCEVPALIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15947 163 LACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSY 242
                       250       260
                ....*....|....*....|....*...
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15947 243 SQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
24-303 3.73e-98

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 290.53  E-value: 3.73e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  24 QVSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYF 103
Cdd:cd15418   1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 104 FVGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLC-DPYINHFFCDTTA 182
Cdd:cd15418  81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCgDNIIDHFFCDLPP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 183 LLALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPD 262
Cdd:cd15418 161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47577609 263 NTSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNALLRV 303
Cdd:cd15418 241 SSHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
27-300 4.84e-98

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 290.05  E-value: 4.84e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15434   3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPY-INHFFCDTTALLA 185
Cdd:cd15434  83 LGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHrVDHFFCEMPALIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15434 163 LACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSV 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15434 243 SQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
28-293 1.11e-97

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 288.58  E-value: 1.11e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  28 FLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGL 107
Cdd:cd15227   4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 108 VCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTALLAL 186
Cdd:cd15227  84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSnVIHQFFCDIPQLLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 187 SCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTSS 266
Cdd:cd15227 164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243
                       250       260
                ....*....|....*....|....*..
gi 47577609 267 LTQAQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15227 244 SLLDLLLSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
25-300 1.20e-96

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 286.53  E-value: 1.20e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15420   1 LLLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPY-INHFFCDTTAL 183
Cdd:cd15420  81 LALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNeVNHFFCEILAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDN 263
Cdd:cd15420 161 LKLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577609 264 TSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15420 241 SNSAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
27-300 2.51e-95

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 283.15  E-value: 2.51e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15405   3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTALLA 185
Cdd:cd15405  83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSnIINHYMCDILPLLQ 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15405 163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVG 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15405 243 SVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
27-293 3.66e-92

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 274.63  E-value: 3.66e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15430   3 LFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLC-DPYINHFFCDTTALLA 185
Cdd:cd15430  83 MGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCgNNVINHFTCEILAVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15430 163 LACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKN 242
                       250       260
                ....*....|....*....|....*...
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15430 243 AQISDKLITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
27-300 1.21e-91

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 273.59  E-value: 1.21e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15432   3 LFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPY-INHFFCDTTALLA 185
Cdd:cd15432  83 LGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRrVDHFFCEVPALLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15432 163 LSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNS 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15432 243 SHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
27-300 1.55e-91

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 273.30  E-value: 1.55e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15234   3 LFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLC-DPYINHFFCDTTALLA 185
Cdd:cd15234  83 FGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCtDVEIPHFFCELAQVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15234 163 LACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVTH 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15234 243 SSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
27-293 2.81e-91

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 272.64  E-value: 2.81e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15915   3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTALLA 185
Cdd:cd15915  83 LGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPnKINHFFCDIKPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKI-QSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNT 264
Cdd:cd15915 163 LACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSG 242
                       250       260
                ....*....|....*....|....*....
gi 47577609 265 SSLTQAQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15915 243 DSLEQDRIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
27-300 1.24e-90

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 271.28  E-value: 1.24e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15428   3 LFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTALLA 185
Cdd:cd15428  83 FGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHnKINHFLCEMPALLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15428 163 LASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSST 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15428 243 SKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
27-300 1.54e-89

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 268.53  E-value: 1.54e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15424   3 LFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTALLA 185
Cdd:cd15424  83 LGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPnHINHFFCELPVVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15424 163 LACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGS 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15424 243 TPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
27-293 2.24e-89

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 267.59  E-value: 2.24e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15232   3 LFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTW 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTALLA 185
Cdd:cd15232  83 SLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPnIINHFFCEIPPLLL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15232 163 LSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSY 242
                       250       260
                ....*....|....*....|....*...
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15232 243 SPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
27-293 1.61e-86

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 260.22  E-value: 1.61e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15939   3 CFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPY-INHFFCDTTALLA 185
Cdd:cd15939  83 FGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNvIDHFFCDLFPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAiLKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPdnTS 265
Cdd:cd15939 163 LACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRP--VT 239
                       250       260
                ....*....|....*....|....*...
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15939 240 TFPIDKVVAVFYTIITPMLNPLIYTLRN 267
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
27-293 3.36e-86

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 259.61  E-value: 3.36e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15914   3 LFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTALLA 185
Cdd:cd15914  83 LGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPnQIQHIFCDFPPLLS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15914 163 LACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSY 242
                       250       260
                ....*....|....*....|....*...
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15914 243 SLDYDRAIAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
27-293 3.70e-85

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 256.86  E-value: 3.70e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15913   3 LFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTALLA 185
Cdd:cd15913  83 LGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPnIIDHFLCDPGPLLA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15913 163 LSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGN 242
                       250       260
                ....*....|....*....|....*...
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15913 243 STGMQKIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
27-300 7.54e-85

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 256.22  E-value: 7.54e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQ-KSISFVGCFVQMYFFV 105
Cdd:cd15916   3 LFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFFH 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 106 GLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTALL 184
Cdd:cd15916  83 FLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPnRIDYFFCDIPPLL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 185 ALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDnt 264
Cdd:cd15916 163 KLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPG-- 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577609 265 SSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15916 241 SKEALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
28-300 5.10e-81

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 246.60  E-value: 5.10e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  28 FLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGL 107
Cdd:cd15236   4 FALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 108 VCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLC-DPYINHFFCDTTALLAL 186
Cdd:cd15236  84 GCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCaDNVIPHFFCDLVALLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 187 SCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTSS 266
Cdd:cd15236 164 SCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNS 243
                       250       260       270
                ....*....|....*....|....*....|....
gi 47577609 267 LTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15236 244 SDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
27-293 2.08e-80

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 244.70  E-value: 2.08e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15946   3 LFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTALLA 185
Cdd:cd15946  83 LGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPnEINHYFCEVPAVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15946 163 LACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNY 242
                       250       260
                ....*....|....*....|....*...
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15946 243 SPERDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
25-293 4.05e-80

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 243.89  E-value: 4.05e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15940   1 LAFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTAL 183
Cdd:cd15940  81 HLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPnEIDSFFCDVPPV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKiQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDn 263
Cdd:cd15940 161 IKLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRK-RSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPS- 238
                       250       260       270
                ....*....|....*....|....*....|
gi 47577609 264 tSSLTQAQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15940 239 -TSFSEDKVVSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
27-293 8.88e-80

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 243.26  E-value: 8.88e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15226   3 LFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPY-INHFFCDTTALLA 185
Cdd:cd15226  83 FGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNvVDSFFCDLPLVIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKiQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15226 163 LACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRK-HSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241
                       250       260
                ....*....|....*....|....*...
gi 47577609 266 SLTqaQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15226 242 PVD--KFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
27-300 9.52e-80

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 243.55  E-value: 9.52e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15233   3 LFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTALLA 185
Cdd:cd15233  83 LAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPnVINHFFCDLPPLFQ 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15233 163 LSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVY 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15233 243 SSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
27-300 9.68e-78

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 238.10  E-value: 9.68e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15228   3 LFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTALLA 185
Cdd:cd15228  83 LGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSnVVDYFFCDIFPVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPdnTS 265
Cdd:cd15228 163 LACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQP--TP 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15228 241 SPVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
27-300 2.08e-77

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 237.38  E-value: 2.08e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15433   3 LFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTALLA 185
Cdd:cd15433  83 LGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHrLLDHFFCEMPVFLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15433 163 LACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRY 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577609 266 SLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15433 243 SQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
27-300 2.11e-76

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 234.63  E-value: 2.11e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15942   3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTALLA 185
Cdd:cd15942  83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKnEVDYIFCDIPAMLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15942 163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQD 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577609 266 SLTqaQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15942 243 PLD--GVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
27-300 2.67e-74

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 229.35  E-value: 2.67e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHT-PMYFFLSNLAFIDIFYSSTVTPKALVDF-QSTQKSISFVGCFVQMYFF 104
Cdd:cd15941   3 FFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLlTLSGRTISFEGCVVQLYAF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTAL 183
Cdd:cd15941  83 HFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPcQIAYFFCDIPPV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPdn 263
Cdd:cd15941 163 LKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQP-- 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577609 264 TSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15941 241 SSSQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
27-293 3.27e-72

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 223.75  E-value: 3.27e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15936   3 LFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPYI-NHFFCDTTALLA 185
Cdd:cd15936  83 TGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVlDNFYCDVPQVIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYlTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15936 163 LACTDTFLLELLMVSNSGLVTLLIFFILLISY-TVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTF 241
                       250       260
                ....*....|....*....|....*...
gi 47577609 266 SLTQAqvASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15936 242 PMDKA--VSVLYTVITPMLNPMIYTLRN 267
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
25-293 9.67e-66

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 207.42  E-value: 9.67e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15938   1 ALLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTAL 183
Cdd:cd15938  81 HFVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPnQVNNFFCDVPPV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 184 LALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIisaILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPdn 263
Cdd:cd15938 161 IKLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARP-- 235
                       250       260       270
                ....*....|....*....|....*....|
gi 47577609 264 TSSLTQAQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15938 236 FSTFPVDKHVSVLYNVITPMLNPLIYTLRN 265
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
27-293 2.43e-62

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 198.42  E-value: 2.43e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15937   3 LFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPYI-NHFFCDTTALLA 185
Cdd:cd15937  83 LGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVlDNFFCDITQVIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYlTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15937 163 LACTNTYTVELLMFSNSGLVILLCFLLLLISY-AFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSF 241
                       250       260
                ....*....|....*....|....*...
gi 47577609 266 SLTqaQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15937 242 PMD--KVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
27-293 4.35e-61

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 195.37  E-value: 4.35e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQL-HTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFV 105
Cdd:cd15935   3 LFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLH 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 106 GLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTALL 184
Cdd:cd15935  83 FLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPnELDNFYCDVPQVI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 185 ALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYlTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNT 264
Cdd:cd15935 163 KLACMDTYVVEVLMVANSGLLSLVCFLVLLVSY-GIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSS 241
                       250       260
                ....*....|....*....|....*....
gi 47577609 265 SSLTqaQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd15935 242 SSVD--KVASVFYTLITPALNPLIYTLRN 268
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
27-300 1.91e-52

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 173.63  E-value: 1.91e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15223   3 LSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQkvcnwlAVIPYMIGFT---NSLISICVI---SSLPLCDP-YINHFFCD 179
Cdd:cd15223  83 FTAMESSILLVMALDRYVAICKPLRYPSIITK------SFILKLVLFAlirSGLLVLPIVvlaSQLSYCSSnVIEHCYCD 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 180 TTALLALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYL 259
Cdd:cd15223 157 HMALVSLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSL 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 47577609 260 --QPDNTSSLTQAQVASVFYTIVIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15223 237 tyRFGKTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
31-296 1.18e-51

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 171.44  E-value: 1.18e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  31 FLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGLVCS 110
Cdd:cd15950   7 FCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 111 ECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNW--LAVIPYMIGFTNSLisICVISSLPLCDPY-INHFFCDTTALLALS 187
Cdd:cd15950  87 ESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQigLAIVLRALLFMTPL--TCLVTSLPYCGSRvVPHSYCEHMAVVKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 188 CVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFY-GSLIFTYLQ--PDNT 264
Cdd:cd15950 165 CADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYiPGLLSIYTQrfGQGV 244
                       250       260       270
                ....*....|....*....|....*....|..
gi 47577609 265 SSLTQAQVASvFYTIVIPMLNPLIYSLRNKDV 296
Cdd:cd15950 245 PPHTQVLLAD-LYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
31-294 1.28e-50

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 168.62  E-value: 1.28e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  31 FLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGLVCS 110
Cdd:cd15917   7 FCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAM 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 111 ECFLLGSMAYDRYVAICNPLLYSVIMSQKVcnwLAVIPYMIGFTNSLI---SICVISSLPLC-DPYINHFFCDTTALLAL 186
Cdd:cd15917  87 ESGVLLAMAFDRYVAICYPLRYTTILTNTV---VGKIGLAILLRAVALiipLPLLVRRLPYCgSNVISHSYCEHMAVVKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 187 SCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLqpdnTSS 266
Cdd:cd15917 164 ACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFL----THR 239
                       250       260       270
                ....*....|....*....|....*....|....
gi 47577609 267 LTQAQVASV------FYTIVIPMLNPLIYSLRNK 294
Cdd:cd15917 240 FGHHVPPHVhillanLYLLLPPMLNPIVYGVRTK 273
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
31-294 6.60e-47

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 158.97  E-value: 6.60e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  31 FLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGLVCS 110
Cdd:cd15953   7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 111 ECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPY-INHFFCDTTALLALSCV 189
Cdd:cd15953  87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRiIPHTYCEHMAVVKLACG 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 190 DAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLqpdnTSSLTQ 269
Cdd:cd15953 167 DTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFL----THRFGQ 242
                       250       260       270
                ....*....|....*....|....*....|.
gi 47577609 270 AQVASV------FYTIVIPMLNPLIYSLRNK 294
Cdd:cd15953 243 GIAPHIhiilanLYLLVPPMLNPIIYGVKTK 273
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
31-296 1.44e-45

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 155.62  E-value: 1.44e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  31 FLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGLVCS 110
Cdd:cd15952   7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 111 ECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPYI-NHFFCDTTALLALSCV 189
Cdd:cd15952  87 ESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIiPHTYCEHMGIAKLACA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 190 DAFNTelVIFVLAGFTLLS-SLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQ---PDNTS 265
Cdd:cd15952 167 SIRIN--IIYGLFAISVLVlDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLThrfGHNIP 244
                       250       260       270
                ....*....|....*....|....*....|.
gi 47577609 266 SLTQAQVASvFYTIVIPMLNPLIYSLRNKDV 296
Cdd:cd15952 245 RYIHILLAN-LYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
29-296 1.41e-44

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 152.89  E-value: 1.41e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  29 LIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGLV 108
Cdd:cd15951   5 IPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 109 CSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPY-INHFFCDTTALLALS 187
Cdd:cd15951  85 TMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNiIPHTYCEHMAVVKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 188 CVD----AFNTELVIFVLAGFTLLSslliITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQ--- 260
Cdd:cd15951 165 CADtrvsRAYGLSVAFLVGGLDVIF----IAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLThrf 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577609 261 PDNTSSLTQAQVASVfYTIVIPMLNPLIYSLRNKDV 296
Cdd:cd15951 241 GHNVPPHVHILIANV-YLLVPPMLNPIIYGVRTKQI 275
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
31-294 2.55e-44

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 152.44  E-value: 2.55e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  31 FLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGLVCS 110
Cdd:cd15221   7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 111 ECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTALLALSCV 189
Cdd:cd15221  87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHnVIPHTYCEHMGIARLACA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 190 DafnteLVIFVLAGFT--LLSSLL---IITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQ---P 261
Cdd:cd15221 167 D-----ITVNIWYGLTvaLLTVGLdvvLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLThrfG 241
                       250       260       270
                ....*....|....*....|....*....|...
gi 47577609 262 DNTSSLTQAQVASVfYTIVIPMLNPLIYSLRNK 294
Cdd:cd15221 242 RHIPRHVHILLANL-YVLVPPMLNPIVYGVKTK 273
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
27-294 1.17e-42

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 148.03  E-value: 1.17e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15222   3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPYI-NHFFCDTTALLA 185
Cdd:cd15222  83 FSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVlSHSYCLHQDVMK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDA-FNTELVIFVLAgFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLI---FTYLQP 261
Cdd:cd15222 163 LACSDTrVNSIYGLFVVL-STMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIglsMVHRFG 241
                       250       260       270
                ....*....|....*....|....*....|...
gi 47577609 262 DNTSSLTQAQVASVfYTIVIPMLNPLIYSLRNK 294
Cdd:cd15222 242 KHASPLVHVLMANV-YLLVPPVLNPIIYSVKTK 273
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
10-297 2.09e-40

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 142.61  E-value: 2.09e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  10 TVFMLSGFSDHPELQVSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQ 89
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  90 KSISFVGCFVQMYFFVGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLC 169
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 170 DPY-INHFFCDTTALLALSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVT 248
Cdd:cd15949 162 RTNiIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIL 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 47577609 249 VFY-----GSLIFTYLQpdNTSSLTQAQVASvFYTIVIPMLNPLIYSLRNKDVK 297
Cdd:cd15949 242 AFYvpiavSSLIHRFGQ--NVPPPTHILLAN-FYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
31-297 4.37e-40

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 141.20  E-value: 4.37e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  31 FLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGLVCS 110
Cdd:cd15948   8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 111 ECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLC-DPYINHFFCDTTALLALSCV 189
Cdd:cd15948  88 ESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCrSHVIAHCYCEHMAVVKLACG 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 190 DAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTylqpdNTSSLTQ 269
Cdd:cd15948 168 DTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLS-----STMHRFA 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577609 270 AQVA-------SVFYTIVIPMLNPLIYSLRNKDVK 297
Cdd:cd15948 243 RHVAphvhillANFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
27-296 4.24e-38

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 136.15  E-value: 4.24e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15956   3 LSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPY-INHFFCDTTALLA 185
Cdd:cd15956  83 FSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHtIAHTYCEHMAVVK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQPDNTS 265
Cdd:cd15956 163 LACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFGH 242
                       250       260       270
                ....*....|....*....|....*....|...
gi 47577609 266 SLTQAQ--VASVFYTIVIPMLNPLIYSLRNKDV 296
Cdd:cd15956 243 SVPSAAhvLLSNLYLLLPPALNPIVYGIRTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
31-304 4.69e-38

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 136.09  E-value: 4.69e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609    31 FLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGLVCS 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609   111 ECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLC-DPYINHFFCDTTALLALSCV 189
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCgHHVLSHSYCLHMGLARLSCA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609   190 D-AFNTELVIFVLAGFTLLSSLLIItFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQ---PDNTS 265
Cdd:pfam13853 161 DiKVNNIYGLFVVTSTFGIDSLLIV-LSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVhrfGHNVP 239
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 47577609   266 SLTQAQVASVfYTIVIPMLNPLIYSLRNKDVKNALLRVI 304
Cdd:pfam13853 240 PLLQIMMANA-YLFFPPVLNPIVYSVKTKQIRDCVKRML 277
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
31-296 6.75e-38

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 135.72  E-value: 6.75e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  31 FLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGLVCS 110
Cdd:cd15954   7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 111 ECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDP-YINHFFCDTTALLALSC- 188
Cdd:cd15954  87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGnFIPHTYCDHMSVVKLACa 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 189 ---VDAFNTELVIFVLAGFtllsSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQ----P 261
Cdd:cd15954 167 nirVDAIYGLMVALLIGGF----DILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAhrfgG 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577609 262 DNTSSLTQAQVASVfYTIVIPMLNPLIYSLRNKDV 296
Cdd:cd15954 243 HHITPHIHIIMANL-YLLLPPMMNPIVYGVKTKQI 276
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
31-296 7.74e-31

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 116.79  E-value: 7.74e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  31 FLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGLVCS 110
Cdd:cd15955   7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 111 ECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVI-----PYMIGFTNSLISICVISslpLCDPYINHFFCDTTALLA 185
Cdd:cd15955  87 ESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLvvvraVVLIIPCPLLIKLRLHH---FRSTVISHSYCEHMAVVK 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LSCVDA----FNTELVIFVLAGFtllsSLLIITFTYLTIISAILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQP 261
Cdd:cd15955 164 LAADDVrvnkIYGLFVAFSILGF----DIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAH 239
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577609 262 DNTSSLTQAQ--VASVFYTIVIPMLNPLIYSLRNKDV 296
Cdd:cd15955 240 RFGHHVAPYVhiLLSNLYLLVPPVLNPIVYGVKTKQI 276
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
41-289 4.67e-28

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 108.92  E-value: 4.67e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609    41 GNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVD-FQSTQKSISFVGCFVQMYFFVGLVCSECFLLGSMA 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYyLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609   120 YDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPlcDPYINHFFCDTTALLALSCvdafnTELVIF 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLT--VPEGNVTVCFIDFPEDLSK-----PVSYTL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609   200 VLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRC-------KAFSTCASHLTGVTVFYGSLIFTYL------QPDNTSS 266
Cdd:pfam00001 154 LISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSSertqrrrKALKTLAVVVVVFILCWLPYHIVNLldslalDCELSRL 233
                         250       260
                  ....*....|....*....|...
gi 47577609   267 LTQAQVASVFYTIVIPMLNPLIY 289
Cdd:pfam00001 234 LDKALSVTLWLAYVNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
27-293 9.39e-14

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 70.01  E-value: 9.39e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFtnslisicVISSLPLCdpYINHFFCDTTALLAL 186
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSL--------LLALPPLL--GWGVYDYGGYCCCCL 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 187 SCVDAFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRC--------------KAFSTCASHLTGVTVFYG 252
Cdd:cd00637 151 CWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSssnssrrrrrrrerKVTKTLLIVVVVFLLCWL 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 47577609 253 SLIFTYL----QPDNTSSLTQAQVASVFYTIVIPMLNPLIYSLRN 293
Cdd:cd00637 231 PYFILLLldvfGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
27-300 7.95e-10

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 58.34  E-value: 7.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd14967   2 LAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFtnslisicVISSLPLcdpYINHFFCDTTALLAL 186
Cdd:cd14967  82 CCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSL--------LISLPPL---VGWRDETQPSVVDCE 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 187 SCVDAFNTELVIFVLAGFTLlsSLLIITFTYLTIISAILKIQsaagrcKAFSTcashltgVTVFYGSLIFTYLqPDNTSS 266
Cdd:cd14967 151 CEFTPNKIYVLVSSVISFFI--PLLIMIVLYARIFRVARREL------KAAKT-------LAIIVGAFLLCWL-PFFIIY 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 47577609 267 LTQA-----QVASVFYTIVI------PMLNPLIYSLRNKDVKNAL 300
Cdd:cd14967 215 LVSAfcppdCVPPILYAVFFwlgylnSALNPIIYALFNRDFRRAF 259
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
30-300 6.80e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 52.68  E-value: 6.80e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  30 IFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGLVC 109
Cdd:cd14972   4 VAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 110 SECFLLgSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISI----CVISSLPLCDPYINHffcdttalla 185
Cdd:cd14972  84 SAYSLL-AIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVlgwnCVLCDQESCSPLGPG---------- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 lscvdaFNTELVIFVLAGFTLLssLLIITFTYLTI-------ISAILKIQSAA-----GRCKAFSTCASHLTGVTVFYGS 253
Cdd:cd14972 153 ------LPKSYLVLILVFFFIA--LVIIVFLYVRIfwclwrhANAIAARQEAAvpaqpSTSRKLAKTVVIVLGVFLVCWL 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577609 254 LIFTYLQPDnTSSLTQAQVASVFYTIVIPML-----NPLIYSLRNKDVKNAL 300
Cdd:cd14972 225 PLLILLVLD-VLCPSVCDIQAVFYYFLVLALlnsaiNPIIYAFRLKEMRRAV 275
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
25-140 7.55e-07

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 49.47  E-value: 7.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPkalvdfQSTQKSIS---FVG---CF 98
Cdd:cd15055   1 VLLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMP------FSMIRSIEtcwYFGdtfCK 74
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 47577609  99 VQMYFFVGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKV 140
Cdd:cd15055  75 LHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRR 116
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
29-299 1.64e-06

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 48.46  E-value: 1.64e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  29 LIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKA-LVDFQSTQKSISFVGCFVQMYFFVGL 107
Cdd:cd15052   5 LLLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSiLTELFGGVWPLPLVLCLLWVTLDVLF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 108 VCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYmigftnsLISICVisSLPLCdpyINHFFCDTTALLALS 187
Cdd:cd15052  85 CTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVW-------LISIGI--SSPIP---VLGIIDTTNVLNNGT 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 188 CVDAFNTelviFVLAG--FTLLSSLLIITFTYltiisaILKIQSAAGRCKAFSTCASHLTGVTVFYGSLIFTYLQP---D 262
Cdd:cd15052 153 CVLFNPN----FVIYGsiVAFFIPLLIMVVTY------ALTIRLLSNEQKASKVLGIVFAVFVICWCPFFITNILTglcE 222
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577609 263 NTSSLTQAQVASVFYTI--VIPMLNPLIYSLRNKDVKNA 299
Cdd:cd15052 223 ECNCRISPWLLSVFVWLgyVSSTINPIIYTIFNKTFRRA 261
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
33-220 1.83e-06

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 48.75  E-value: 1.83e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  33 FIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGLVCSEC 112
Cdd:cd15959   9 LAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 113 FLLGSMAYDRYVAICNPLLYSVIMSqKVCNWLAVIpyMIGFTNSLISICvisslplcdPYINHFFCDTTALLALSCVD-- 190
Cdd:cd15959  89 ETLCAIAVDRYLAITNPLRYEALVT-KRRARTAVC--LVWAISAAISFL---------PIMNQWWRDGADEEAQRCYDnp 156
                       170       180       190
                ....*....|....*....|....*....|....
gi 47577609 191 ---AFNTELVIFVLAG-FTLLSSLLIITFTYLTI 220
Cdd:cd15959 157 rccDFVTNMPYAIVSStVSFYVPLLVMIFVYVRV 190
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
32-139 3.06e-06

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 47.63  E-value: 3.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  32 LFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVdfQSTQKSISFVGCFVQMYFFVGLVCSE 111
Cdd:cd14968   8 VLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAIL--ISLGLPTNFHGCLFMACLVLVLTQSS 85
                        90       100
                ....*....|....*....|....*...
gi 47577609 112 CFLLGSMAYDRYVAICNPLLYSVIMSQK 139
Cdd:cd14968  86 IFSLLAIAIDRYLAIKIPLRYKSLVTGR 113
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
25-140 4.93e-06

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 47.35  E-value: 4.93e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15312   1 VAMYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLD 80
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKV 140
Cdd:cd15312  81 MMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPV 116
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
25-156 5.66e-06

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 47.16  E-value: 5.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15316   1 VILYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCD 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNS 156
Cdd:cd15316  81 VSFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYS 132
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
25-153 7.64e-06

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 46.67  E-value: 7.64e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVdfqSTQKSISFVG---CFVQM 101
Cdd:cd15317   1 VIIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMI---RTVETCWYFGdlfCKFHT 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 47577609 102 YFFVGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVC------NWLAVIPYMIGF 153
Cdd:cd15317  78 GLDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAwrfiaiGWLVPGIYTFGL 135
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
32-154 8.08e-06

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 46.46  E-value: 8.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  32 LFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKAL---VDFQSTQKSISFVGCFVQMyffvgLV 108
Cdd:cd15069   8 LIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAItisLGFCTDFHSCLFLACFVLV-----LT 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47577609 109 CSECFLLGSMAYDRYVAICNPLLYSVIMSQK----VCNWLAVIPYMIGFT 154
Cdd:cd15069  83 QSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKrargVIAVLWVLAFGIGLT 132
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
29-300 8.49e-06

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 46.44  E-value: 8.49e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  29 LIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVD-FQSTQKSISFVGCFVQMYFFVGL 107
Cdd:cd15305   5 LLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAiLYDYAWPLPRYLCPIWISLDVLF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 108 VCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVcnwlAVIPYMIGFTnslISICVisSLPLcdPYINhFFCDTTALLALS 187
Cdd:cd15305  85 STASIMHLCAISLDRYVAIRNPIEHSRFNSRTK----AMMKIAAVWT---ISIGI--SMPI--PVIG-LQDDEKVFVNGT 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 188 CVdaFNTELVIFVLAGFTLLSSLLIITFTYLTIISAILKIQSAAGRCKafstcASHLTGVTV---------FYGSLIFTY 258
Cdd:cd15305 153 CV--LNDENFVLIGSFVAFFIPLIIMVITYCLTIQVLQRQQAINNERR-----ASKVLGIVFflflimwcpFFITNILSV 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 47577609 259 LQPDNTSSLTQAQVASVFYTI--VIPMLNPLIYSLRNKDVKNAL 300
Cdd:cd15305 226 LCKEACDQKLMEELLNVFVWVgyVSSGINPLVYTLFNKTYRRAF 269
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
25-139 1.33e-05

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 45.65  E-value: 1.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVdfQSTQKSISFVGCFVQMYFF 104
Cdd:cd15325   1 IVLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAI--FEILGYWAFGRVFCNIWAA 78
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 47577609 105 VGLVCSECFLLG--SMAYDRYVAICNPLLYSVIMSQK 139
Cdd:cd15325  79 VDVLCCTASIMSlcIISIDRYIGVSYPLRYPSIMTER 115
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
33-147 1.77e-05

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 45.53  E-value: 1.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  33 FIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSI-SFVGCFVQMYFFVGLVCSE 111
Cdd:cd15005   9 LILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCKVIAFLAVLFCFHS 88
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 47577609 112 CFLLGSMAYDRYVAICNPLLYSVIMSQKVCnwLAVI 147
Cdd:cd15005  89 AFTLFCIAVTRYMAIAHHRFYAKRMTFWTC--LAVI 122
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
29-177 5.70e-05

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 43.87  E-value: 5.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  29 LIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKAL-VDFQSTQKSISFVGCFVQMYFFVGL 107
Cdd:cd15053   5 LFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVyVEVNGGKWYLGPILCDIYIAMDVMC 84
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 108 VCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPYINHFF 177
Cdd:cd15053  85 STASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRDPEECRFY 154
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
32-153 8.21e-05

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 43.39  E-value: 8.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  32 LFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVdfQSTQKSISFVGCFVQMYFFVGLVCSE 111
Cdd:cd15068   8 LAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSS 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 47577609 112 CFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGF 153
Cdd:cd15068  86 IFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSF 127
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
25-135 1.02e-04

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 42.96  E-value: 1.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIylFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCfvQMYFF 104
Cdd:cd14969   3 LAVYLSLIGV--LGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGC--VIYGF 78
                        90       100       110
                ....*....|....*....|....*....|...
gi 47577609 105 VGLVCSEC--FLLGSMAYDRYVAICNPLLYSVI 135
Cdd:cd14969  79 AVTFLGLVsiSTLAALAFERYLVIVRPLKAFRL 111
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
25-138 1.06e-04

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 43.21  E-value: 1.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15058   1 PGLLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVD 80
                        90       100       110
                ....*....|....*....|....*....|....
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQ 138
Cdd:cd15058  81 VLCVTASIETLCVIAVDRYIAITRPLRYQVLLTK 114
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
25-139 1.31e-04

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 42.86  E-value: 1.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPkalvdFQSTQKSI---SFVGCFVQM 101
Cdd:cd15062   1 IVVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLP-----FSATLEVLgywAFGRIFCDV 75
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 47577609 102 YFFVGLVCSECFLLG--SMAYDRYVAICNPLLYSVIMSQK 139
Cdd:cd15062  76 WAAVDVLCCTASIMSlcVISVDRYIGVRYPLNYPTIVTAR 115
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
25-130 1.75e-04

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 42.49  E-value: 1.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15202   1 VLLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQ 80
                        90       100
                ....*....|....*....|....*.
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPL 130
Cdd:cd15202  81 YCSVHVSAYTLTAIAVDRYQAIMHPL 106
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
36-139 2.17e-04

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 42.19  E-value: 2.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  36 LFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPkalvdFQSTQKSIS---FVGCFVQMYFFVGLVC--S 110
Cdd:cd15326  12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLP-----FSATLEILGywvFGRIFCDIWAAVDVLCctA 86
                        90       100
                ....*....|....*....|....*....
gi 47577609 111 ECFLLGSMAYDRYVAICNPLLYSVIMSQK 139
Cdd:cd15326  87 SILSLCAISIDRYIGVRHSLQYPTIVTRK 115
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
25-139 2.90e-04

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 41.82  E-value: 2.90e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGC----FVQ 100
Cdd:cd14993   1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCkavpYLQ 80
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 47577609 101 MYFfvglVCSECFLLGSMAYDRYVAICNPLLYSVIMSQK 139
Cdd:cd14993  81 GVS----VSASVLTLVAISIDRYLAICYPLKARRVSTKR 115
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
27-155 3.28e-04

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 41.49  E-value: 3.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVG 106
Cdd:cd15329   3 IGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDVL 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYSV------IMSQKVCNWLA----VIPYMIGFTN 155
Cdd:cd15329  83 LCTASILNLCAISVDRYLVITRPLTYAVkrtpkrMALMIAIVWLLsaliSIPPLFGWKN 141
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
27-299 3.66e-04

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 41.19  E-value: 3.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIY-LFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVdFQSTQKSISF--VGCFVQMYF 103
Cdd:cd15067   1 LLGVVLSLFcLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSIL-HEMTGGYWLFgrDWCDVWHSF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 104 FVgLVCSECFL-LGSMAYDRYVAICNPLLYSVIMSQKVCnWLAVIpyMIGFTNSLISICVI-----SSLPLCDPYINHFF 177
Cdd:cd15067  80 DV-LASTASILnLCVISLDRYWAITDPISYPSRMTKRRA-LIMIA--LVWICSALISFPAIawwraVDPGPSPPNQCLFT 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 178 CDTTALLALSCVdafntelvifvlagfTLLSSLLIITFTYLTIISAILKIQSAAGRCK----AFSTCAshltgvTVFYGS 253
Cdd:cd15067 156 DDSGYLIFSSCV---------------SFYIPLVVMLFTYYRIYRAAAKEQKAAKTLGivmgVFILCW------LPFFVT 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 47577609 254 LIFTYLQPDNTssLTQAQVASVFYT---IVIPMLNPLIYSLRNKDVKNA 299
Cdd:cd15067 215 NILIGFCPSNC--VSNPDILFPLVTwlgYINSGMNPIIYACSSRDFRRA 261
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
29-160 4.38e-04

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 41.18  E-value: 4.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  29 LIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGLV 108
Cdd:cd15065   4 IFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCS 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577609 109 CSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISI 160
Cdd:cd15065  84 TASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPI 135
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
30-164 5.38e-04

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 41.05  E-value: 5.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  30 IFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYS----STVTPKALVDFQSTQKSISFVGC--FVQMYF 103
Cdd:cd15353   6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSvsngSETVVITLLNGNDTDAQSFTVNIdnVIDSVI 85
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47577609 104 FVGLVCSECFLLgSMAYDRYVAICNPLLYSVIMSQK------VCNWLAV----IPYMIGFTNSLISICVIS 164
Cdd:cd15353  86 CSSLLASICSLL-SIAVDRYFTIFYALQYHNIMTVRragviiTCIWTACtvsgVLFIIYSDSSVVIICLIS 155
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-133 6.19e-04

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 40.87  E-value: 6.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  28 FLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYS-STVTPKALVDFQSTQKSISFVgCFVQMYFFVG 106
Cdd:cd15197   4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGlINVLTDIIWRITVEWRAGDFA-CKVIRYLQVV 82
                        90       100
                ....*....|....*....|....*..
gi 47577609 107 LVCSECFLLGSMAYDRYVAICNPLLYS 133
Cdd:cd15197  83 VTYASTYVLVALSIDRYDAICHPMNFS 109
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
30-139 6.27e-04

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 40.55  E-value: 6.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  30 IFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQ-------MY 102
Cdd:cd15103   6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQhidnvidSM 85
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 47577609 103 FFVGLVCSECFLLgSMAYDRYVAICNPLLYSVIMSQK 139
Cdd:cd15103  86 ICSSLLASICSLL-AIAVDRYITIFYALRYHSIMTVR 121
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
25-139 6.54e-04

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 40.80  E-value: 6.54e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQStQKSISFVGCFVQMYFF 104
Cdd:cd14979   1 VLVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWW-QYPWAFGDGGCKLYYF 79
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 47577609 105 VGLVCSECFLLG--SMAYDRYVAICNPLLYSVIMSQK 139
Cdd:cd14979  80 LFEACTYATVLTivALSVERYVAICHPLKAKTLVTKR 116
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
34-130 7.28e-04

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 40.44  E-value: 7.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  34 IYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYS-STVTPKALVDFqSTQKSISFVGCFVQMYFFVGLVCSEC 112
Cdd:cd14986  10 LFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAfFTVLTQIIWEA-TGEWVAGDVLCRIVKYLQVVGLFAST 88
                        90
                ....*....|....*...
gi 47577609 113 FLLGSMAYDRYVAICNPL 130
Cdd:cd14986  89 YILVSMSLDRYQAIVKPM 106
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
25-153 9.61e-04

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 40.16  E-value: 9.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15056   1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLD 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLA---VIPYMIGF 153
Cdd:cd15056  81 VLLTTASIMHLCCIALDRYYAICCQPLVYKMTPLRVAVMLGgcwVIPTFISF 132
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
36-132 9.63e-04

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 40.23  E-value: 9.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  36 LFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVdfQSTQKSISFVGCFVQMYFFVGLV--CSECF 113
Cdd:cd15318  12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTI--RSVESCWYFGDSFCRLHTCLDTLfcLTSIF 89
                        90
                ....*....|....*....
gi 47577609 114 LLGSMAYDRYVAICNPLLY 132
Cdd:cd15318  90 HLCFISIDRHCAICDPLLY 108
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
30-139 1.01e-03

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 39.89  E-value: 1.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  30 IFLFIY-LFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPkalvdFQSTQKSISFVG---CFVQMYFFV 105
Cdd:cd15327   5 VFLAIFiLMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLP-----FSATLEVLGFWAfgrVFCDIWAAV 79
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 47577609 106 GLVCSECFLLG--SMAYDRYVAICNPLLYSVIMSQK 139
Cdd:cd15327  80 DVLCCTASILSlcVISVDRYVGVKHSLKYPTIMTER 115
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
25-139 1.01e-03

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 40.02  E-value: 1.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15059   1 VAISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALD 80
                        90       100       110
                ....*....|....*....|....*....|....*
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQK 139
Cdd:cd15059  81 VLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPR 115
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
34-154 1.01e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 40.15  E-value: 1.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  34 IYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVdfQSTQKSISFVGCFVQMYFFVGLVCSECF 113
Cdd:cd15070  10 IGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIV--VSLGVTIHFYSCLFMSCLLVVFTHASIM 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47577609 114 LLGSMAYDRYVAICNPLLYSVIMSQKVCnWLAV-----IPYMIGFT 154
Cdd:cd15070  88 SLLAIAVDRYLRVKLTVRYRIVTTQRRI-WLALglcwlVSFLVGLT 132
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
25-208 1.02e-03

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 39.92  E-value: 1.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15314   1 VLLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSFD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKvcnwlaVIPYMIGFT---NSLISICVI-SSLPLCDPYINHFFCDT 180
Cdd:cd15314  81 ITLCTASILNLCFISIDRYYAVCQPLLYRSKITVR------VVLVMILISwsvSALVGFGIIfLELNIKGIYYNHVACEG 154
                       170       180
                ....*....|....*....|....*...
gi 47577609 181 TALLALSCVDAFNTELVIFVLAGFTLLS 208
Cdd:cd15314 155 GCLVFFSKVSSVVGSVFSFYIPAVIMLC 182
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
33-201 1.05e-03

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 39.92  E-value: 1.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  33 FIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGLVCSEC 112
Cdd:cd15323   9 FLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 113 FLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGFTNSLISICVISSLPLCDPYINHFFCDTTALLALSCVDAF 192
Cdd:cd15323  89 VHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDPEGDVYPQCKLNDETWYILSSCIGSF 168

                ....*....
gi 47577609 193 NTELVIFVL 201
Cdd:cd15323 169 FAPCLIMIL 177
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
33-153 1.12e-03

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 39.91  E-value: 1.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  33 FIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYS-STVTPKALVDFqstqkSISFVG----C----FVQMyf 103
Cdd:cd15196   9 TILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAlFNVLPQLIWDI-----TYRFYGgdllCrlvkYLQV-- 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47577609 104 fVGLVCSEcFLLGSMAYDRYVAICNPLLySVIMSQKVCNWLAVIPYMIGF 153
Cdd:cd15196  82 -VGMYASS-YVLVATAIDRYIAICHPLS-SHRWTSRRVHLMVAIAWVLSL 128
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
22-130 1.22e-03

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 39.80  E-value: 1.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  22 ELQVSLFLIFLFIYLFtvwGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSS-TVTPKALVDFQSTQKSISFVGCFVQ 100
Cdd:cd15387   1 KVEVTVLALILFLALT---GNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfQVLPQLIWDITFRFYGPDFLCRLVK 77
                        90       100       110
                ....*....|....*....|....*....|
gi 47577609 101 MYFFVGLVCSeCFLLGSMAYDRYVAICNPL 130
Cdd:cd15387  78 YLQVVGMFAS-TYMLLLMSIDRCLAICQPL 106
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
29-154 1.73e-03

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 39.41  E-value: 1.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  29 LIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGLV 108
Cdd:cd15979   5 LLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSV 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47577609 109 CSECFLLGSMAYDRYVAICNPL----------LYSVIMSQKVCNWLAVIPYMIGFT 154
Cdd:cd15979  85 SVSTFSLVAIAIERYSAICNPLqsrvwqtrshAYRVIAATWLLSGLIMIPYPVYSV 140
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
27-157 1.83e-03

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 39.51  E-value: 1.83e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIF---YSSTVTPKALVDFQSTQKSISfvgCFVQMYF 103
Cdd:cd15203   3 LILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLlclVSLPFTLIYTLTKNWPFGSIL---CKLVPSL 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 47577609 104 FVGLVCSECFLLGSMAYDRYVAICNPLlySVIMSQKVCNWLAVIPYMIGFTNSL 157
Cdd:cd15203  80 QGVSIFVSTLTLTAIAIDRYQLIVYPT--RPRMSKRHALLIIALIWILSLLLSL 131
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
33-133 1.89e-03

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 39.23  E-value: 1.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  33 FIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVdFQSTQKSIsFVGCFVQMYFFVGLVCSEC 112
Cdd:cd15064   9 LIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAV-YELTGRWI-LGQVLCDIWISLDVTCCTA 86
                        90       100
                ....*....|....*....|...
gi 47577609 113 FL--LGSMAYDRYVAICNPLLYS 133
Cdd:cd15064  87 SIlhLCVIALDRYWAITDAVEYA 109
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
33-141 2.05e-03

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 39.16  E-value: 2.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  33 FIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQS-TQKSISFVGCFVQMYFFVGLVCSE 111
Cdd:cd15217   9 LIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNgSAWTYSVLSCKIVAFMAVLFCFHA 88
                        90       100       110
                ....*....|....*....|....*....|
gi 47577609 112 CFLLGSMAYDRYVAICNPLLYSVIMSQKVC 141
Cdd:cd15217  89 AFMLFCISVTRYMAIAHHRFYSKRMTFWTC 118
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
29-133 2.23e-03

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 39.15  E-value: 2.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  29 LIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQK-SISFVGCFVQMYFFVGL 107
Cdd:cd15304   5 LLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRwPLPSKLCAVWIYLDVLF 84
                        90       100
                ....*....|....*....|....*.
gi 47577609 108 VCSECFLLGSMAYDRYVAICNPLLYS 133
Cdd:cd15304  85 STASIMHLCAISLDRYIAIRNPIHHS 110
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
57-300 2.57e-03

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 38.89  E-value: 2.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  57 TPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGLVCSECFLLGSMAYDRYVAICNPLLYSVIM 136
Cdd:cd15104  33 TKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITSCAASVLSLAAIAFDRYLALKQPLRYKQIM 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 137 SQKVCNWLAVIPYMIGFtnslisicVISSLPLCDPYINhffcdTTALLALSCVDAFNTELVIFVLAGFTLLSSLLIITFT 216
Cdd:cd15104 113 TGKSAGALIAGLWLYSG--------LIGFLPLISPQFQ-----QTSYKGKCSFFAAFHPRVLLVLSCMVFFPALLLFVFC 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 217 YLTIIS-------AILKIQSAAGRCKAFSTCASH---LTGVTVFYGSLIFTYLqPDNTSSLTQAQVASVFYTIVI----- 281
Cdd:cd15104 180 YCDILKiarvhsrAIYKVEHALARQIHPRRTLSDfkaARTVAVLIGCFLLSWL-PFQITGLVQALCDECKLYDVLedylw 258
                       250       260
                ....*....|....*....|....*
gi 47577609 282 ------PMLNPLIYSLRNKDVKNAL 300
Cdd:cd15104 259 llglcnSLLNPWIYAFWQKEVRRAL 283
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
25-153 3.42e-03

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 38.25  E-value: 3.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15063   1 LISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVD 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPLLYSVIMSQKVCNWLAVIPYMIGF 153
Cdd:cd15063  81 VWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSF 129
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
25-132 3.48e-03

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 38.18  E-value: 3.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCfvQMYFF 104
Cdd:cd15050   1 APLGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVC--LFWLS 78
                        90       100       110
                ....*....|....*....|....*....|
gi 47577609 105 VGLVCSEC--FLLGSMAYDRYVAICNPLLY 132
Cdd:cd15050  79 MDYVASTAsiFSLFILCIDRYRSVQQPLKY 108
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
29-130 3.63e-03

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 38.37  E-value: 3.63e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  29 LIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDifySSTVTPKALVDFQSTQKSISFVG---CFVQMYFFV 105
Cdd:cd16003   5 LAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSD---ASMAAFNTLINFIYALHSEWYFGeayCRFHNFFPI 81
                        90       100
                ....*....|....*....|....*
gi 47577609 106 GLVCSECFLLGSMAYDRYVAICNPL 130
Cdd:cd16003  82 TSVFASIYSMTAIAVDRYMAIIDPL 106
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
27-130 3.71e-03

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 38.33  E-value: 3.71e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  27 LFLIFLFIYLFTVWGNiGLIMLIRIDSQ-LHTPMYFFLSNLAFIDIFYSSTvTPKALVDFQSTQKSISFVGCfvQMYFFV 105
Cdd:cd15079   3 LGFIYIFLGIVSLLGN-GLVIYIFSTTKsLRTPSNMLVVNLAISDFLMMIK-MPIFIYNSFYEGWALGPLGC--QIYAFL 78
                        90       100
                ....*....|....*....|....*..
gi 47577609 106 GLVCSEC--FLLGSMAYDRYVAICNPL 130
Cdd:cd15079  79 GSLSGIGsiWTNAAIAYDRYNVIVKPL 105
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
23-133 4.33e-03

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 38.24  E-value: 4.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  23 LQVSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMY 102
Cdd:cd15333   3 LKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLS 82
                        90       100       110
                ....*....|....*....|....*....|.
gi 47577609 103 FFVGLVCSECFLLGSMAYDRYVAICNPLLYS 133
Cdd:cd15333  83 SDITCCTASILHLCVIALDRYWAITDAVEYS 113
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
30-139 6.34e-03

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 37.56  E-value: 6.34e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  30 IFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQM-------Y 102
Cdd:cd15352   6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHmdnvfdsM 85
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 47577609 103 FFVGLVCSECFLLgSMAYDRYVAICNPLLYSVIMSQK 139
Cdd:cd15352  86 ICISLVASICNLL-AIAVDRYVTIFYALRYHSIMTVR 121
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
33-139 6.51e-03

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 37.61  E-value: 6.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  33 FIYLFTVWGN-IGLIMLIRiDSQLH--TPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQK---SISFVGCFVQMYFFVG 106
Cdd:cd14981   9 LMFVFGVLGNlLALIVLAR-SSKSHkwSVFYRLVAGLAITDLLGILLTSPVVLAVYASNFEwdgGQPLCDYFGFMMSFFG 87
                        90       100       110
                ....*....|....*....|....*....|...
gi 47577609 107 LvcSECFLLGSMAYDRYVAICNPLLYSVIMSQK 139
Cdd:cd14981  88 L--SSLLIVCAMAVERFLAITHPFFYNSHVKKR 118
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
29-126 8.42e-03

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 37.16  E-value: 8.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  29 LIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFFVGLV 108
Cdd:cd15346   5 VVFIIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPTQWFLREGSMFVALS 84
                        90
                ....*....|....*...
gi 47577609 109 CSeCFLLGSMAYDRYVAI 126
Cdd:cd15346  85 AS-VFSLLAIAIERYITM 101
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
25-130 8.48e-03

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 37.27  E-value: 8.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  25 VSLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQKSISFVGCFVQMYFF 104
Cdd:cd15390   1 VLWSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVA 80
                        90       100
                ....*....|....*....|....*.
gi 47577609 105 VGLVCSECFLLGSMAYDRYVAICNPL 130
Cdd:cd15390  81 ITTVAASVFTLMAISIDRYIAIVHPL 106
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
26-297 9.58e-03

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 37.10  E-value: 9.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609  26 SLFLIFLFIYLFTVWGNIGLIMLIRIDSQLHTPMYFFLSNLAFIDIFYSSTVTPKALVDFQSTQkSISFVGCFVQMYFFV 105
Cdd:cd15347   2 VASIFIVILCCIIVLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGVAFIANILLSGSVTF-RLTPVQWFIREGTAF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 106 GLVCSECFLLGSMAYDRYVAICNPLLYSvimSQKVCNWLAVIPymigfTNSLISIcVISSLPLCDPYINHFFCDTTALLA 185
Cdd:cd15347  81 ITLSASVFSLLAIAIERHVAITKVKLYG---SDKNCRMVLLIG-----ACWVISI-VLGGLPILGWNCIGNLEDCSTVLP 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577609 186 LscvdaFNTELVIFVLAGFTLLssLLIITFTYLTIisaILKIQSAAGRCKAFSTCAShLTGVTVFYGSLI------FTYL 259
Cdd:cd15347 152 L-----YSKHYILFVVTIFSII--LLSIVILYVRI---YCIVRSSHAEMAAPQTLAL-LKTVTIVLGVFIvcwlpaFIIL 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 47577609 260 QPDNTSSLTQAQV---ASVFYTIVI--PMLNPLIYSLRNKDVK 297
Cdd:cd15347 221 LLDTSCKVKSCPIlykADYFFSVATlnSALNPVIYTLRSKDMR 263
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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