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Conserved domains on  [gi|47578039|ref|NP_001000146|]
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olfactory receptor Olr105 [Rattus norvegicus]

Protein Classification

olfactory receptor family 51 protein( domain architecture ID 11607012)

olfactory receptor family 51 protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
28-302 4.44e-150

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320350  Cd Length: 275  Bit Score: 421.91  E-value: 4.44e-150
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  28 WTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIH 107
Cdd:cd15222   2 WISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 108 TFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVL 187
Cdd:cd15222  82 TFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVM 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 188 RLSCSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFG 267
Cdd:cd15222 162 KLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRFG 241
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47578039 268 rKKLPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEI 302
Cdd:cd15222 242 -KHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
 
Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
28-302 4.44e-150

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 421.91  E-value: 4.44e-150
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  28 WTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIH 107
Cdd:cd15222   2 WISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 108 TFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVL 187
Cdd:cd15222  82 TFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVM 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 188 RLSCSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFG 267
Cdd:cd15222 162 KLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRFG 241
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47578039 268 rKKLPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEI 302
Cdd:cd15222 242 -KHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
34-310 1.71e-95

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 283.62  E-value: 1.71e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039    34 CLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIE 113
Cdd:pfam13853   2 CLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIME 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039   114 SAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSS 193
Cdd:pfam13853  82 SAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCAD 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039   194 TVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFGRkKLPA 273
Cdd:pfam13853 162 IKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGH-NVPP 240
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 47578039   274 QVYMLLSYLHFLMPPMLNPIVYSVKTKEIRVRILKML 310
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
21-161 2.23e-03

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 39.38  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039   21 GLETSHCWTAIPICLIYILSVLGNIIIMhIVKSVPSLHTPMYLFLSMLSMADLgLSASTLPSMVAVFLLGQRLIGAAACF 100
Cdd:PHA03087  35 GYDTNSTILIVVYSTIFFFGLVGNIIVI-YVLTKTKIKTPMDIYLLNLAVSDL-LFVMTLPFQIYYYILFQWSFGEFACK 112
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47578039  101 MQ--LFFIHTFSVIesAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPL 161
Cdd:PHA03087 113 IVsgLYYIGFYNSM--NFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPI 173
 
Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
28-302 4.44e-150

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 421.91  E-value: 4.44e-150
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  28 WTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIH 107
Cdd:cd15222   2 WISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 108 TFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVL 187
Cdd:cd15222  82 TFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVM 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 188 RLSCSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFG 267
Cdd:cd15222 162 KLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRFG 241
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47578039 268 rKKLPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEI 302
Cdd:cd15222 242 -KHASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
27-302 1.05e-106

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 312.30  E-value: 1.05e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  27 CWTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFI 106
Cdd:cd15917   1 IWLSIPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 107 HTFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDV 186
Cdd:cd15917  81 HSFTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 187 LRLSCSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRF 266
Cdd:cd15917 161 VKLACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47578039 267 GRkKLPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEI 302
Cdd:cd15917 241 GH-HVPPHVHILLANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
28-302 6.13e-100

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 295.02  E-value: 6.13e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  28 WTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIH 107
Cdd:cd15951   2 WISIPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 108 TFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVL 187
Cdd:cd15951  82 SFSTMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 188 RLSCSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFG 267
Cdd:cd15951 162 KLACADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFG 241
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47578039 268 rKKLPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEI 302
Cdd:cd15951 242 -HNVPPHVHILIANVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
28-302 1.72e-98

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 291.12  E-value: 1.72e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  28 WTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIH 107
Cdd:cd15221   2 WISIPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 108 TFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVL 187
Cdd:cd15221  82 FVFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 188 RLSCSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFG 267
Cdd:cd15221 162 RLACADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRFG 241
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47578039 268 RkKLPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEI 302
Cdd:cd15221 242 R-HIPRHVHILLANLYVLVPPMLNPIVYGVKTKQI 275
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
27-302 1.61e-96

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 286.08  E-value: 1.61e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  27 CWTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFI 106
Cdd:cd15953   1 IWISIPFCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 107 HTFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDV 186
Cdd:cd15953  81 HTLSIMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 187 LRLSCSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRF 266
Cdd:cd15953 161 VKLACGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRF 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47578039 267 GRkKLPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEI 302
Cdd:cd15953 241 GQ-GIAPHIHIILANLYLLVPPMLNPIIYGVKTKEI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
34-310 1.71e-95

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 283.62  E-value: 1.71e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039    34 CLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIE 113
Cdd:pfam13853   2 CLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIME 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039   114 SAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSS 193
Cdd:pfam13853  82 SAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCAD 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039   194 TVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFGRkKLPA 273
Cdd:pfam13853 162 IKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGH-NVPP 240
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 47578039   274 QVYMLLSYLHFLMPPMLNPIVYSVKTKEIRVRILKML 310
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
28-302 1.36e-91

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 273.49  E-value: 1.36e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  28 WTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIH 107
Cdd:cd15952   2 WIGFPFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 108 TFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVL 187
Cdd:cd15952  82 TFTGMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 188 RLSCSSTVVNSGFGLFVmLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFG 267
Cdd:cd15952 162 KLACASIRINIIYGLFA-ISVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFG 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47578039 268 RkKLPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEI 302
Cdd:cd15952 241 H-NIPRYIHILLANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
26-303 1.67e-90

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 271.01  E-value: 1.67e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  26 HCWTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFF 105
Cdd:cd15948   1 HPWISIPFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 106 IHTFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPD 185
Cdd:cd15948  81 LHSFSIMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 186 VLRLSCSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHR 265
Cdd:cd15948 161 VVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTMHR 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47578039 266 FGRKKLPaQVYMLLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15948 241 FARHVAP-HVHILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
14-303 3.68e-89

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 268.18  E-value: 3.68e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  14 FILMDLPGLETSHCWTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRL 93
Cdd:cd15949   4 FILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSSNE 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  94 IGAAACFMQLFFIHTFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPV 173
Cdd:cd15949  84 IPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWYRT 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 174 SALSHSYCVHPDVLRLSCSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLF 253
Cdd:cd15949 164 NIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAILAF 243
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 47578039 254 YTPLVSLSMIHRFGRkKLPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15949 244 YVPIAVSSLIHRFGQ-NVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
28-302 2.87e-88

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 265.43  E-value: 2.87e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  28 WTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIH 107
Cdd:cd15950   2 WIAIPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 108 TFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVL 187
Cdd:cd15950  82 SFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 188 RLSCSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFG 267
Cdd:cd15950 162 KLACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIYTQRFG 241
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47578039 268 rKKLPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEI 302
Cdd:cd15950 242 -QGVPPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
28-306 8.97e-84

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 253.75  E-value: 8.97e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  28 WTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIH 107
Cdd:cd15223   2 WLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 108 TFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVL 187
Cdd:cd15223  82 FFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 188 RLSCSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFG 267
Cdd:cd15223 162 SLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFG 241
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47578039 268 rKKLPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEIRVRI 306
Cdd:cd15223 242 -KTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
27-302 2.65e-79

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 242.37  E-value: 2.65e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  27 CWTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFI 106
Cdd:cd15955   1 HWIGIPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 107 HTFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLG-RLAFQPVSALSHSYCVHPD 185
Cdd:cd15955  81 HTLQAFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIKlRLHHFRSTVISHSYCEHMA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 186 VLRLSCSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHR 265
Cdd:cd15955 161 VVKLAADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHR 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47578039 266 FGRkKLPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEI 302
Cdd:cd15955 241 FGH-HVAPYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
28-302 5.05e-75

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 231.68  E-value: 5.05e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  28 WTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIH 107
Cdd:cd15956   2 WLSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 108 TFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVL 187
Cdd:cd15956  82 AFSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 188 RLSCSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFG 267
Cdd:cd15956 162 KLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFG 241
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47578039 268 RkKLPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEI 302
Cdd:cd15956 242 H-SVPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
28-302 3.74e-70

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 218.92  E-value: 3.74e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  28 WTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIH 107
Cdd:cd15954   2 WISIPFCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 108 TFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVL 187
Cdd:cd15954  82 TFTGMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 188 RLSCSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFG 267
Cdd:cd15954 162 KLACANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRFG 241
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47578039 268 RKKLPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEI 302
Cdd:cd15954 242 GHHITPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
31-298 1.68e-65

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 206.95  E-value: 1.68e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  31 IPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFS 110
Cdd:cd13954   5 VLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 111 VIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLS 190
Cdd:cd13954  85 GTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 191 CSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHrfgRKK 270
Cdd:cd13954 165 CSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRP---SSS 241
                       250       260
                ....*....|....*....|....*...
gi 47578039 271 LPAQVYMLLSYLHFLMPPMLNPIVYSVK 298
Cdd:cd13954 242 YSSDLDKVVSVFYTVVTPMLNPIIYSLR 269
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
33-304 2.09e-53

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 176.11  E-value: 2.09e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  33 ICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVI 112
Cdd:cd15225   7 FLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 113 ESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCS 192
Cdd:cd15225  87 ECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLACA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 193 STVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFY--TPLVSL--SMIHRFGR 268
Cdd:cd15225 167 DTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYgcASFTYLrpKSSYSPET 246
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47578039 269 KKlpaqvymLLSYLHFLMPPMLNPIVYSVKTKEIRV 304
Cdd:cd15225 247 DK-------LLSLFYTVVTPMLNPIIYSLRNKEVKG 275
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
35-303 6.23e-53

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 174.72  E-value: 6.23e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15235  10 AMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDS 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSST 194
Cdd:cd15235  90 FLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCSDT 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 VVNSGF----GLFVMLSTLgmdaVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMihrfgrkk 270
Cdd:cd15235 170 SLNELLifteGAVVVLGPF----LLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYF-------- 237
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47578039 271 LPAQVY-----MLLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15235 238 QPSSSYsadkdRVATVMYTVVTPMLNPFIYSLRNKDVK 275
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
35-303 7.12e-51

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 169.37  E-value: 7.12e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15231   9 IIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILttRRIGAIGLAVVV-----RSAALHlplPVLLGRLAFQPVSALSHSYCVHPDVLRL 189
Cdd:cd15231  89 LLLAVMAYDRYVAICNPLHYAVIM--SRKVCLQLAAASwlcgfLNSAVH---TVLTFRLSFCGSNQISHFFCDIPPLLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 190 SCSSTVVNSgFGLFVMLSTLGMDAVL-ILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTplvslSMIHRFGR 268
Cdd:cd15231 164 SCSDTSLNE-VLLLVASVFIGLTPFLfIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYG-----TAIFNYNR 237
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47578039 269 --KKLPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15231 238 psSGYSLDKDTLISVLYSIVTPMLNPIIYSLRNKEVK 274
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
36-296 8.57e-49

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 163.94  E-value: 8.57e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  36 IYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIESA 115
Cdd:cd15918  10 MYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDNF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 116 ILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSSTV 195
Cdd:cd15918  90 LLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCSDTH 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 196 VNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSL----SMIHRFGRKKL 271
Cdd:cd15918 170 LNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVylspPSSHSASKDSV 249
                       250       260
                ....*....|....*....|....*
gi 47578039 272 PAQVYMLLSylhflmpPMLNPIVYS 296
Cdd:cd15918 250 AAVMYTVVT-------PMLNPFIYS 267
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
33-296 1.01e-48

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 163.60  E-value: 1.01e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  33 ICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVI 112
Cdd:cd15237   7 FLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 113 ESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCS 192
Cdd:cd15237  87 ECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKLACA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 193 STVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMihRFGRKKLP 272
Cdd:cd15237 167 DTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYM--RPHSTHSP 244
                       250       260
                ....*....|....*....|....
gi 47578039 273 AQVYMlLSYLHFLMPPMLNPIVYS 296
Cdd:cd15237 245 DQDKM-ISVFYTIVTPMLNPLIYS 267
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
35-303 1.32e-48

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 163.65  E-value: 1.32e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15420   9 LLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRigAIGLAVVVRSAALHLPLP--VLLGRLAFQPVSALSHSYCVHPDVLRLSCS 192
Cdd:cd15420  89 VLLAVMSYDRYVAICHPLRYTVIMNWRV--CTTLAATSWACGFLLALVhvVLLLRLPFCGPNEVNHFFCEILAVLKLACA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 193 STVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFGRKKLP 272
Cdd:cd15420 167 DTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNSAEQ 246
                       250       260       270
                ....*....|....*....|....*....|.
gi 47578039 273 AQVymlLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15420 247 EKI---LSLFYSLFNPMLNPLIYSLRNKQVK 274
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
35-298 3.33e-48

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 162.29  E-value: 3.33e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15230   9 LIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIgaIGLAVVVRSAAL--HLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCS 192
Cdd:cd15230  89 FLLAAMAYDRYVAICNPLLYTVIMSKRVC--IQLVAGSYLCGFvnSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 193 ST----VVNSGFGLFVMLSTLgmdaVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLvsLSMIHRFGR 268
Cdd:cd15230 167 DThineLVLFAFSGFIGLSTL----LIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTL--IFMYLRPSS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 47578039 269 KKLPAQVyMLLSYLHFLMPPMLNPIVYSVK 298
Cdd:cd15230 241 SYSLDQD-KVVSVFYTVVIPMLNPLIYSLR 269
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
35-303 4.70e-48

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 162.49  E-value: 4.70e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15408  22 LIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKVISFTGCLTQLYFYAVFATTEC 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTR-RIGAIGLAVV--VRSAALHlplPVLLGRLAFQPVSALSHSYCVHPDVLRLSC 191
Cdd:cd15408 102 YLLAAMAYDRYVAICNPLLYTVIMSQRvCVSLVAGSYLagFLNSTVH---TGFILRLSFCGSNVINHFFCDGPPLLALSC 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 192 SSTVVNSG----FGLFVMLSTlgmdAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFG 267
Cdd:cd15408 179 SDTSLNEMllfaFVGFNVLTT----TLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLFYGSLAFMYLRPSSR 254
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47578039 268 RKKLPAQVymlLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15408 255 YSLDLDKV---ASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
35-308 6.28e-48

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 162.10  E-value: 6.28e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15411   9 VIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRigAIGLAVVVRSAAL--HLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCS 192
Cdd:cd15411  89 FLLGLMAYDRYVAICNPLLYTVVMSRRV--CLKLAAGSYAAGFlnSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLSCS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 193 STVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFGRKKLP 272
Cdd:cd15411 167 DTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSYSLGQ 246
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47578039 273 AQVymlLSYLHFLMPPMLNPIVYSVKTKEIRVRILK 308
Cdd:cd15411 247 DKV---ASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
35-303 8.27e-48

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 161.61  E-value: 8.27e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15229   9 VIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEA 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSST 194
Cdd:cd15229  89 FLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSCSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 VVNS----GFGLFVMLSTLgmdaVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLvslsmihrFGRKK 270
Cdd:cd15229 169 FANKmvllTSSVIFGLGSF----LLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTG--------FFRYL 236
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47578039 271 LPAQVY-----MLLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15229 237 RPNSASssvldRVFSIQYSILTPMLNPIIYSLKNKEVK 274
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
35-303 1.81e-46

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 158.19  E-value: 1.81e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15417   9 GIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSST 194
Cdd:cd15417  89 FLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLSCSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 VVNSgFGLFVMLSTLGMDAVL-ILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFGRKKLPA 273
Cdd:cd15417 169 FISQ-VVLFLVAVLFGVFSVLvVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSHSQDQD 247
                       250       260       270
                ....*....|....*....|....*....|
gi 47578039 274 QVymlLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15417 248 KV---ASVFYTVVIPMLNPLIYSLRNKEIK 274
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
35-303 2.37e-46

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 157.91  E-value: 2.37e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15416   9 VIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCS-- 192
Cdd:cd15416  89 FLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKLSCSdi 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 193 --STVVNSGFGLFVMLSTLgmdaVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFGRKK 270
Cdd:cd15416 169 rlAKILPSISSGIIILVTV----LTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYSM 244
                       250       260       270
                ....*....|....*....|....*....|...
gi 47578039 271 LPAQVymlLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15416 245 DQNKV---VSVFYMVVIPMLNPLIYSLRNKEVK 274
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
35-303 3.26e-46

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 157.56  E-value: 3.26e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15412   9 VIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEY 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSST 194
Cdd:cd15412  89 YMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLSCSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 VVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSL----SMIHRFGRKK 270
Cdd:cd15412 169 YVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMylrpPSEESVEQSK 248
                       250       260       270
                ....*....|....*....|....*....|...
gi 47578039 271 LPAQVYMLLSylhflmpPMLNPIVYSVKTKEIR 303
Cdd:cd15412 249 IVAVFYTFVS-------PMLNPLIYSLRNKDVK 274
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
35-304 1.13e-45

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 155.81  E-value: 1.13e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15234   9 SMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDN 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSST 194
Cdd:cd15234  89 FLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLACSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 VVNSGFgLFVMLSTLGMDAVL-ILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFY-TPL---VSLSMIHrFGRK 269
Cdd:cd15234 169 LINNIL-IYLATVIFGGIPLSgIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYgTGLgvyISSAVTH-SSRK 246
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47578039 270 KLPAQVymllsyLHFLMPPMLNPIVYSVKTKEIRV 304
Cdd:cd15234 247 TAVASV------MYTVVTPMLNPFIYSLRNKDMKG 275
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
33-296 2.42e-45

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 154.95  E-value: 2.42e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  33 ICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVI 112
Cdd:cd15912   7 LLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 113 ESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCS 192
Cdd:cd15912  87 EFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLKLSCS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 193 ST----VVNSGFGLFVMLSTLgmdaVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTplvslSMIHRFGR 268
Cdd:cd15912 167 DTrlieLLDFILASVVLLGSL----LLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYG-----SCIFMYVR 237
                       250       260       270
                ....*....|....*....|....*....|...
gi 47578039 269 kklPAQVYML-----LSYLHFLMPPMLNPIVYS 296
Cdd:cd15912 238 ---PSQSSSLdlnkvVALLNTVVTPLLNPFIYT 267
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
33-302 2.84e-45

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 155.02  E-value: 2.84e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  33 ICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVI 112
Cdd:cd15421   7 ILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 113 ESAILLAMAFDRCVAIREPLRYaTILTTRR----------IGAIGLAVVVRSAALHLPlpvllgrlaFQPVSALSHSYCV 182
Cdd:cd15421  87 ECLLLALMAYDRYVAICHPLRY-PVLMSPRvcllmaagswLGGSLNSLIHTVYTMHFP---------YCGSREIHHFFCE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 183 HPDVLRLSCSSTvvnSGFGLFVMLSTLGMDAV---LILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVS 259
Cdd:cd15421 157 VPALLKLSCADT---SAYETVVYVSGVLFLLIpfsLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIF 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 47578039 260 LSMihRFGRKKLPAQvYMLLSYLHFLMPPMLNPIVYSVKTKEI 302
Cdd:cd15421 234 TYM--RPGSYHSPEQ-DKVVSVFYTILTPMLNPLIYSLRNKEV 273
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
35-296 6.74e-45

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 153.76  E-value: 6.74e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15227   9 LIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASEL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRS---AALHlplPVLLGRLAFQPVSALSHSYCVHPDVLRLSC 191
Cdd:cd15227  89 ALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGllyGALH---TANTFSLPFCGSNVIHQFFCDIPQLLKLSC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 192 SSTVVNSgFGLFVMLSTLGMDA-VLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYtplVSLSMIHRFGRKK 270
Cdd:cd15227 166 SDTYLNE-IGVLVLSVCLGLGCfVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFL---STGSFAYLKPPSD 241
                       250       260
                ....*....|....*....|....*.
gi 47578039 271 LPAQVYMLLSYLHFLMPPMLNPIVYS 296
Cdd:cd15227 242 SPSLLDLLLSVFYSVVPPTLNPIIYS 267
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
35-296 2.02e-44

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 152.64  E-value: 2.02e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15911   9 VIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRR----------IGAIGLAVVVrsaalhlplpVLLGRLAFQPVSALSHSYCVHP 184
Cdd:cd15911  89 YLLAVMSYDRYLAICKPLHYASLMNGRLclqlaagswiSGFLASTITV----------ILMSQLTFCGPNEIDHFFCDFA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 185 DVLRLSCSST----VVNSGFGLFVMLSTLgmdaVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSL 260
Cdd:cd15911 159 PLLKLSCSDTslveLVTFILSSIVTLPPF----LLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIV 234
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47578039 261 SMIHRFGRKKLPAQVymlLSYLHFLMPPMLNPIVYS 296
Cdd:cd15911 235 YVVPSTNTSRDLNKV---FSLFYTVLTPLVNPLIYS 267
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
35-310 1.36e-43

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 151.27  E-value: 1.36e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15410  22 AIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKAISYSGCMLQFFFFCTFVVTES 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILtTRRIGAIGLAVVVRSAALH-LPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSS 193
Cdd:cd15410 102 FLLAVMAYDRYVAICNPLLYTVIM-SRKLCVLLVAGSYLWGIVCsLIHTCGLLRLSFCGSNVINHFFCDLPPLLSLSCSD 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 194 TVVN----SGFGLFVMLSTLgmdaVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLvsLSMIHRFGRK 269
Cdd:cd15410 181 TYLNelllFIFGSLNEASTL----LIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIFHGTI--LFMYCRPSSS 254
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47578039 270 KLPAQVYMlLSYLHFLMPPMLNPIVYSVKTKEIRVRILKML 310
Cdd:cd15410 255 YSLDTDKV-ASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
14-303 3.00e-43

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 150.21  E-value: 3.00e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  14 FILMDLPGLETSHCWTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRL 93
Cdd:cd15943   2 FILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  94 IGAAACFMQLFFIHTFSVIESAILLAMAFDRCVAIREPLRYaTILTTRRIGAIGLAVVVRSAALHLPLPVLLG-RLAFQP 172
Cdd:cd15943  82 ISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLY-TVIMSPRVCIQLVAGSYLIGFVNALIQTICTfRLPFCG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 173 VSALSHSYCVHPDVLRLSCSSTVVNsGFGLFVMLSTLGMDAVL-ILLSYVLILKTVLSIASNAERLKAFNTCISHICAVL 251
Cdd:cd15943 161 SNVINHFFCDVPPLLKLSCSDTHVN-EIVLFAFAIFLGIFTSLeILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVT 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47578039 252 LFYTPLVSLSMihrfgrkkLPAQVYML-----LSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15943 240 IFYGTTLFMYL--------RPSSSYSLdqdkvVSVFYTVVIPMLNPLIYSLRNKEVK 288
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
35-296 4.36e-43

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 148.91  E-value: 4.36e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15431   9 IVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRigAIGLAVVVRSAALHLPL-PVLLGRLAFQPVSALSHSYCVHPDVLRLSCSS 193
Cdd:cd15431  89 LLLAVMAYDRFVAICNPLRYTLIMSWRV--CIQLAAGSWVSAFLLTViPVLTMPLHFCGPNVINHFFCEVQALLKLACSD 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 194 TVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFgrKKLPA 273
Cdd:cd15431 167 TSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQS--KSSSD 244
                       250       260
                ....*....|....*....|...
gi 47578039 274 QVYMlLSYLHFLMPPMLNPIVYS 296
Cdd:cd15431 245 QDKI-ISVFYGVVTPMLNPLIYS 266
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
35-302 1.01e-42

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 148.32  E-value: 1.01e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15409   9 AIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTR---RIGAIGLAVVVRSAALHLplpVLLGRLAFQPVSALSHSYCVHPDVLRLSC 191
Cdd:cd15409  89 FLLAAMAYDRYVAICNPLLYPVVMSNRlcvQLITASYIGGFLHSMIHV---GLTFRLSFCGSNEINHFFCDIPPLLKISC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 192 SSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFGRKkl 271
Cdd:cd15409 166 TDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYA-- 243
                       250       260       270
                ....*....|....*....|....*....|.
gi 47578039 272 pAQVYMLLSYLHFLMPPMLNPIVYSVKTKEI 302
Cdd:cd15409 244 -LDQDMMDSLFYTIVIPLLNPFIYSLRNKEV 273
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
36-310 2.30e-42

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 147.90  E-value: 2.30e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  36 IYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIESA 115
Cdd:cd15406  19 IYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVFAIAECY 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 116 ILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSSTV 195
Cdd:cd15406  99 MLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPLLKLSCSSTY 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 196 VNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSL----SMIHRFGRKKL 271
Cdd:cd15406 179 INELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMylkpSSSSSMTQEKV 258
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47578039 272 PAQVYMLLSylhflmpPMLNPIVYSVKTKEIRVRILKML 310
Cdd:cd15406 259 SSVFYTTVI-------PMLNPLIYSLRNKDVKNALKKVL 290
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
35-303 3.94e-42

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 146.68  E-value: 3.94e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15419   9 VIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEG 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTR---RIGAIGLAVVVRSAALHLPLPVllgRLAFQPVSALSHSYCVHPDVLRLSC 191
Cdd:cd15419  89 FLLAAMAYDRFIAICNPLLYPVIMSRRvcvQLVAGSYLCGCINSIIQTSFTF---SLSFCGSNEIDHFFCDVPPLLKLSC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 192 SSTVVNS----GFGLFVMLSTlgmdAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLvsLSMIHRFG 267
Cdd:cd15419 166 SDTFINElvmfVLCGLIIVST----ILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTV--FFMYAQPG 239
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47578039 268 RKKLPAQVYMlLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15419 240 AVSSPEQSKV-VSVFYTLVIPMLNPLIYSLRNKDVK 274
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
35-303 4.26e-42

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 147.20  E-value: 4.26e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15945  22 LVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSIPFYGCALQMFFFAAFADAEC 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSST 194
Cdd:cd15945 102 LLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGSNTINHFFCDIPPLLALSCSDT 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 VVNSGFGL----FVMLSTLgmdaVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLvsLSMIHRFGRKK 270
Cdd:cd15945 182 QINELLLFalcgFIQTSTF----LAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLFYGTL--LFMYLRPSSSY 255
                       250       260       270
                ....*....|....*....|....*....|...
gi 47578039 271 LPAQVYMlLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15945 256 SLDTDKM-TSVFYTLVIPMLNPLIYSLRNKDVK 287
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
35-303 7.58e-42

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 146.03  E-value: 7.58e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15407   9 LIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFATVEN 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRS---AALHLplpVLLGRLAFQPVSALSHSYCVHPDVLRLSC 191
Cdd:cd15407  89 FLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGflnASIHT---GNTFRLSFCKSNVINHFFCDIPPVLALSC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 192 SSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSL----SMIHRFG 267
Cdd:cd15407 166 SDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMylqpSSSHSMD 245
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47578039 268 RKKLPAQVYMLLSylhflmpPMLNPIVYSVKTKEIR 303
Cdd:cd15407 246 TDKMASVFYTMVI-------PMLNPLVYSLRNKEVK 274
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
33-302 1.92e-41

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 144.88  E-value: 1.92e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  33 ICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVI 112
Cdd:cd15424   7 ILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGST 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 113 ESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCS 192
Cdd:cd15424  87 ECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 193 STVVNS----GFGLFVMLSTLGmdavLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFG- 267
Cdd:cd15424 167 DTHITEaivfGAGVLILLVPLS----VILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGs 242
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47578039 268 ---RKKLPAQVYMLLSylhflmpPMLNPIVYSVKTKEI 302
Cdd:cd15424 243 tpdRDKQIAVFYIVIT-------PLLNPIIYTLRNKDV 273
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
31-298 2.05e-41

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 144.82  E-value: 2.05e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  31 IPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFS 110
Cdd:cd15914   5 ILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 111 VIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLS 190
Cdd:cd15914  85 ITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 191 CSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLvsLSMIHRFgRKK 270
Cdd:cd15914 165 CTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSV--SFMYLRL-SKS 241
                       250       260
                ....*....|....*....|....*...
gi 47578039 271 LPAQVYMLLSYLHFLMPPMLNPIVYSVK 298
Cdd:cd15914 242 YSLDYDRAIAVVYAVLTPFFNPIIYSLR 269
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
35-303 1.14e-40

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 142.85  E-value: 1.14e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15413   9 VIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISEL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSST 194
Cdd:cd15413  89 FLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 VVNS----GFGLFVMLSTLgmdaVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSM----IHRF 266
Cdd:cd15413 169 HEKEliilIFAGFNLISSL----LIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLqpksSHSL 244
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47578039 267 GRKKLPAQVYMLLSylhflmpPMLNPIVYSVKTKEIR 303
Cdd:cd15413 245 DTDKMASVFYTLVI-------PMLNPLIYSLRNKEVK 274
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
35-296 2.57e-40

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 142.01  E-value: 2.57e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15232   9 FLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSEL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSST 194
Cdd:cd15232  89 LLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 VVNSGFgLFVMLSTLGM-DAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPL----VSLSMIHRFGRK 269
Cdd:cd15232 169 SLNEIM-AFVADVFFGVgNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTViytyIRPSSSYSPEKD 247
                       250       260
                ....*....|....*....|....*..
gi 47578039 270 KLPAQVYMLLSylhflmpPMLNPIVYS 296
Cdd:cd15232 248 KVVAVLYSVVT-------PTLNPLIYS 267
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
35-303 2.60e-40

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 142.17  E-value: 2.60e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15415   9 LIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEG 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSST 194
Cdd:cd15415  89 FLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCSDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 VVNSGFgLFVMLSTLGMDAVL-ILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPlVSLSMIHrfgrkklPA 273
Cdd:cd15415 169 HINELL-LLTFSGVIAMSTLLtIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGS-VSFSYIQ-------PS 239
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47578039 274 QVYML-----LSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15415 240 SQYSLeqekvSAVFYTLVIPMLNPLIYSLRNKDVK 274
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
35-310 7.17e-40

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 141.46  E-value: 7.17e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15944  22 IIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKVISFSGCATQFAFFVGFVDAEC 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSST 194
Cdd:cd15944 102 YVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGSNIINHFFCDVPPLLALSCSDT 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 VVNS----GFGLFVMLSTLgmdaVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMihrfgrkk 270
Cdd:cd15944 182 HINEillyVFCGFVEMSSL----SIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLFYGTVIFMYL-------- 249
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 47578039 271 LPAQVYML-----LSYLHFLMPPMLNPIVYSVKTKEIRVRILKML 310
Cdd:cd15944 250 RPTSVYSLdqdkwASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
36-303 1.10e-39

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 140.23  E-value: 1.10e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  36 IYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIESA 115
Cdd:cd15429  10 MYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEFI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 116 ILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSSTV 195
Cdd:cd15429  90 LLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLACVDTS 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 196 VNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMihrFGRKKLPAQV 275
Cdd:cd15429 170 LNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYM---RPRSGSSALQ 246
                       250       260
                ....*....|....*....|....*...
gi 47578039 276 YMLLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15429 247 EKMISLFYAVVTPMLNPLIYSLRNKEVK 274
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
37-303 1.36e-39

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 140.31  E-value: 1.36e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  37 YILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIESAI 116
Cdd:cd15432  11 YILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGSTECVL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 117 LLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSSTVV 196
Cdd:cd15432  91 LAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCVDTTA 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 197 NSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFGRKKLPAQvy 276
Cdd:cd15432 171 NEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNSSHDRGK-- 248
                       250       260
                ....*....|....*....|....*..
gi 47578039 277 mLLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15432 249 -MVALFYGIITPMLNPLIYTLRNKDVK 274
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
35-298 3.95e-39

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 138.50  E-value: 3.95e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15939   9 LIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILtTRRIGAIGLAVVVRSAALHLPLPVLLG-RLAFQPVSALSHSYC-VHPdVLRLSCS 192
Cdd:cd15939  89 FLLTVMAYDRYVAICKPLHYTTIM-NRRVCGLLVGVAWVGGFLHSTIQILLTlQLPFCGPNVIDHFFCdLFP-LLKLACT 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 193 STVVnsgFGLFVMLSTlGMDAVLI----LLSYVLILKTvLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSM--IHRF 266
Cdd:cd15939 167 DTYV---IGLLVVANS-GLICLLSflilLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMrpVTTF 241
                       250       260       270
                ....*....|....*....|....*....|..
gi 47578039 267 GRKKLPAQVYMllsylhfLMPPMLNPIVYSVK 298
Cdd:cd15939 242 PIDKVVAVFYT-------IITPMLNPLIYTLR 266
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
35-298 4.91e-39

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 138.59  E-value: 4.91e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15915   9 LLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEA 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTR---RIGAIGLAVVVRSAALHLplpVLLGRLAFQPVSALSHSYCVHPDVLRLSC 191
Cdd:cd15915  89 MLLAVMAYDRYVAICNPLRYTVIMNPQvclLLAVACWVTGFFHALMHT---VMTSRLPFCGPNKINHFFCDIKPLLKLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 192 SSTVVNSGFgLFVMLSTLGMDA-VLILLSYVLILKTVLSIASNAE-RLKAFNTCISHICAVLLFYTPLVSLSMIHRFGrk 269
Cdd:cd15915 166 GDTSLNLWL-LNIVTGSIALGTfILTLLSYIYIISFLLLKVRSKEgRHKAFSTCASHLTVVLLLYGPALFTYIRPSSG-- 242
                       250       260
                ....*....|....*....|....*....
gi 47578039 270 kLPAQVYMLLSYLHFLMPPMLNPIVYSVK 298
Cdd:cd15915 243 -DSLEQDRIVALLYTVVTPVLNPLIYTLR 270
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
36-304 6.05e-39

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 138.32  E-value: 6.05e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  36 IYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIESA 115
Cdd:cd15405  10 IYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISECY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 116 ILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSSTV 195
Cdd:cd15405  90 VLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLSCTSTY 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 196 VNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFY--------TPLVSLSMIHRfg 267
Cdd:cd15405 170 VNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFgsgafmylKPSSVGSVNQG-- 247
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47578039 268 rkKLPAQVYMLLSylhflmpPMLNPIVYSVKTKEIRV 304
Cdd:cd15405 248 --KVSSVFYTNVV-------PMLNPLIYSLRNKDVKL 275
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
35-314 8.30e-39

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 138.33  E-value: 8.30e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15414   9 LVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTR---RIGAIGLAVVVRSAALHlplPVLLGRLAFQPVSALSHSYCVHPDVLRLSC 191
Cdd:cd15414  89 FLLASMAYDRYVAICNPLLYTVIMSQRvcvQLVVGPYVVGLLNTTTH---TTAAFFLPFCGPNVINHFFCDIPPLLSLSC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 192 SSTVVNSgFGLFVMLSTLG-MDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVslsMIHRFGRKK 270
Cdd:cd15414 166 ADTQINK-WVLFIMAGALGvLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLF---FIYVRPSSS 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 47578039 271 LPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEIRVRILKMLHPKK 314
Cdd:cd15414 242 SSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRRKM 285
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
35-303 1.07e-38

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 137.95  E-value: 1.07e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15942   9 VVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSST 194
Cdd:cd15942  89 FLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 VVNSGFgLFVMLSTLGMDAV-LILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMihRFGRKKLPA 273
Cdd:cd15942 169 AFNELV-TFIDIGLVAMTCFlLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYL--RPGSQDPLD 245
                       250       260       270
                ....*....|....*....|....*....|
gi 47578039 274 QVymlLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15942 246 GV---VAVFYTTVTPLLNPVIYTLRNKEMK 272
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
35-295 4.68e-38

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 135.87  E-value: 4.68e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15224   9 IAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSST 194
Cdd:cd15224  89 VLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLSCTDM 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 VVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTplVSLSMIHRfGRKKLPAQ 274
Cdd:cd15224 169 SLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYS--ATLFMYAR-PKAISSFD 245
                       250       260
                ....*....|....*....|.
gi 47578039 275 VYMLLSYLHFLMPPMLNPIVY 295
Cdd:cd15224 246 SNKLVSVLYTVVTPLLNPIIY 266
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
35-303 4.74e-38

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 136.04  E-value: 4.74e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFL-LGQRLIGAAACFMQLFFIHTFSVIE 113
Cdd:cd15916   9 IIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLePGGKVISFGGCVAQLYFFHFLGSTE 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 114 SAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSS 193
Cdd:cd15916  89 CFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLACAD 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 194 TVVNSgfglFVMLSTLGMDA----VLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMihrfgRK 269
Cdd:cd15916 169 TTINE----LVIFASIGVVAlgcfILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYL-----RP 239
                       250       260       270
                ....*....|....*....|....*....|....
gi 47578039 270 KLPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15916 240 GSKEALDGVIAVFYTVVTPLLNPLIYTLRNKEVK 273
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
34-298 9.03e-38

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 135.02  E-value: 9.03e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  34 CLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIE 113
Cdd:cd15226   8 SLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSE 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 114 SAILLAMAFDRCVAIREPLRYATILTTRR-IG------AIGLAVVVRSAALHLPLPvllgrlaFQPVSALSHSYCVHPDV 186
Cdd:cd15226  88 MVLLIAMAFDRYVAICKPLHYLTIMSPRMcILlvvaswIIGFIHSLSQLAFVVNLP-------FCGPNVVDSFFCDLPLV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 187 LRLSCSST-------VVNSGfglFVMLSTLgmdaVLILLSYVLILKTVLSIASNAeRLKAFNTCISHICAVLLFYTPLVs 259
Cdd:cd15226 161 IKLACTDTyvlelmvVANSG---LISLVCF----LLLLISYIVILVTVRKHSSGG-SSKALSTCSAHITVVVLFFGPCI- 231
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47578039 260 lsMIHRFGRKKLPAQVYmlLSYLHFLMPPMLNPIVYSVK 298
Cdd:cd15226 232 --FIYVWPFSTFPVDKF--LAVFYTVITPLLNPIIYTLR 266
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
36-303 8.09e-37

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 132.94  E-value: 8.09e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  36 IYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIESA 115
Cdd:cd15228  10 FYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTECL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 116 ILLAMAFDRCVAIREPLRYaTILTTRRIGAIGLAVVVRSAALHLP-LPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSST 194
Cdd:cd15228  90 LYTVMAYDRYVAICHPLRY-LLIMNRRVCALLAAGTWITSSFHATiLTSLTFTLPYCGSNVVDYFFCDIFPVLKLACADT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 -----VVNSGFGLFVMLSTLgmdavLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPlVSLSMIHRFGRK 269
Cdd:cd15228 169 siaetVSFTNVGLVPLTCFL-----LILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGP-CALIYTQPTPSP 242
                       250       260       270
                ....*....|....*....|....*....|....
gi 47578039 270 KLPAQVYMLLSylhfLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15228 243 VLVTPVQIFNN----VVTPMLNPLIYTLRNKEVK 272
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
36-303 1.15e-36

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 132.58  E-value: 1.15e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  36 IYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIESA 115
Cdd:cd15236  10 MYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 116 ILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSSTV 195
Cdd:cd15236  90 LLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSSTS 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 196 VNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFGRKKLPAQV 275
Cdd:cd15236 170 LNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNSSDKDIV 249
                       250       260
                ....*....|....*....|....*...
gi 47578039 276 ymlLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15236 250 ---ASVMYTVVTPMLNPFIYSLRNRDIK 274
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
35-303 1.29e-36

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 132.22  E-value: 1.29e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15233   9 LAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSST 194
Cdd:cd15233  89 FLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLSCSST 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 VVNsGFGLFVMLSTLGM-DAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFGRKKLPA 273
Cdd:cd15233 169 HLN-ELLLFVFAFFMALaPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVYSSDKD 247
                       250       260       270
                ....*....|....*....|....*....|
gi 47578039 274 QVymlLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15233 248 KV---IGILNTVLSPMLNPLIYSLRNKDVK 274
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
32-298 1.42e-36

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 132.11  E-value: 1.42e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  32 PICLI-YILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFS 110
Cdd:cd15430   5 VLCLImYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 111 VIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLS 190
Cdd:cd15430  85 STECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 191 CSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLvsLSMIHRFGRKK 270
Cdd:cd15430 165 CVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTI--LFMYMKPKSKN 242
                       250       260
                ....*....|....*....|....*...
gi 47578039 271 LPAqVYMLLSYLHFLMPPMLNPIVYSVK 298
Cdd:cd15430 243 AQI-SDKLITLFYGVVTPMLNPIIYSLR 269
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
35-298 2.64e-36

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 131.28  E-value: 2.64e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15913   9 VIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVrSAALHLPLPV-LLGRLAFQPVSALSHSYCVHPDVLRLSCSS 193
Cdd:cd15913  89 FFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWV-CGFLWFLIPVvLISQLPFCGPNIIDHFLCDPGPLLALSCVP 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 194 T----VVNSGFGLFVMLSTLgmdaVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTplvSLSMIHRFGRK 269
Cdd:cd15913 168 ApgteLICYTLSSLIIFGTF----LFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYG---SVMVMYVSPGS 240
                       250       260
                ....*....|....*....|....*....
gi 47578039 270 KLPAQVYMLLSYLHFLMPPMLNPIVYSVK 298
Cdd:cd15913 241 GNSTGMQKIVTLFYSVVTPLLNPLIYSLR 269
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
33-298 4.38e-36

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 130.82  E-value: 4.38e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  33 ICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVI 112
Cdd:cd15947   7 VLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGST 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 113 ESAILLAMAFDRCVAIREPLRYATILTTR-------RIGAIGLAVVVRSAALHLPLPvLLGRlafqpvSALSHSYCVHPD 185
Cdd:cd15947  87 ECVLLAVMAFDRYVAVCRPLHYTVIMHPRlcvqlaaLSWLSGLANSLLQTTLTLQLP-LCGH------HTLDHFFCEVPA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 186 VLRLSCSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHR 265
Cdd:cd15947 160 LIKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPP 239
                       250       260       270
                ....*....|....*....|....*....|...
gi 47578039 266 FGRKKLPAQvymLLSYLHFLMPPMLNPIVYSVK 298
Cdd:cd15947 240 SSYSQDQGK---FISLFYTVVTPTLNPLIYTLR 269
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
36-303 7.74e-36

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 130.29  E-value: 7.74e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  36 IYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIESA 115
Cdd:cd15428  10 IYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITECA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 116 ILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSSTv 195
Cdd:cd15428  90 LLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLASTDT- 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 196 VNSGFGLFVM-LSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFGRKKlpaQ 274
Cdd:cd15428 169 HQAEMAMFIMcVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSSTSK---E 245
                       250       260
                ....*....|....*....|....*....
gi 47578039 275 VYMLLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15428 246 YDKMISVFYIIVTPMLNPLIYSLRNKEVK 274
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
33-303 1.94e-35

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 129.42  E-value: 1.94e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  33 ICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVI 112
Cdd:cd15434   7 VLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLGGT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 113 ESAILLAMAFDRCVAIREPLRYATILTTR---RIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSalsHSYCVHPDVLRL 189
Cdd:cd15434  87 ECVLLAVMAYDRYAAVCQPLHYTVVMHPRlcwKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVD---HFFCEMPALIKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 190 SCSSTVVNSG----FGLFVMLSTLgmdaVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIhr 265
Cdd:cd15434 164 ACVDTTAYEAtifaLGVFILLFPL----SLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQ-- 237
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47578039 266 fGRKKLPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15434 238 -PKNSVSQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVK 274
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
35-298 2.57e-35

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 128.61  E-value: 2.57e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15936   9 LVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSST 194
Cdd:cd15936  89 FLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLACTDT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 VVNSgfglFVMLSTLGMDAVLI----LLSYVLILKTVLSIASNAERlKAFNTCISHICAVLLFYTPLVslsMIHRFGRKK 270
Cdd:cd15936 169 FLLE----LLMVSNSGLVTLLIffilLISYTVILVKIRTHVTEGKR-KALSTCASQITVVTLIFVPCI---YIYARPFQT 240
                       250       260
                ....*....|....*....|....*...
gi 47578039 271 LPAQvyMLLSYLHFLMPPMLNPIVYSVK 298
Cdd:cd15936 241 FPMD--KAVSVLYTVITPMLNPMIYTLR 266
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
36-298 9.56e-35

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 127.17  E-value: 9.56e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  36 IYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIESA 115
Cdd:cd15940  10 LYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 116 ILLAMAFDRCVAIREPLRYATILTTR----RIGAIGLAVVVRSaalhLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSC 191
Cdd:cd15940  90 LLTIMAYDRYVAICNPLHYPTVMNHKvclwLVAALWLGGTVHS----LAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLAC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 192 SST-------VVNSGFGLFVMLstlgmdaVLILLSYVLILKTVLSIASNAeRLKAFNTCISHICAVLLFYTPLVSLSMih 264
Cdd:cd15940 166 TDTylidiliVSNSGLISLVCF-------VALLGSYIVILVSLRKRSTEG-RRKALSTCASHLTVVTLFFGPCIFIYT-- 235
                       250       260       270
                ....*....|....*....|....*....|....
gi 47578039 265 rfgRKKLPAQVYMLLSYLHFLMPPMLNPIVYSVK 298
Cdd:cd15940 236 ---RPSTSFSEDKVVSVFYTVVTPLLNPIIYTLR 266
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
35-298 2.46e-33

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 123.36  E-value: 2.46e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15946   9 LIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSST 194
Cdd:cd15946  89 TLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKLACADT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 VVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMihRFGRKKLPAQ 274
Cdd:cd15946 169 SLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYM--RPGSNYSPER 246
                       250       260
                ....*....|....*....|....
gi 47578039 275 VYMlLSYLHFLMPPMLNPIVYSVK 298
Cdd:cd15946 247 DKK-ISLFYNVFTALLNPVIYSLR 269
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
35-303 2.49e-33

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 123.74  E-value: 2.49e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15418  10 LSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSEC 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSST 194
Cdd:cd15418  90 FLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACDDT 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 VVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSL----SMIHRFGRKK 270
Cdd:cd15418 170 RVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIysrpSSSHTPDRDK 249
                       250       260       270
                ....*....|....*....|....*....|...
gi 47578039 271 LPAQVYMLLSylhflmpPMLNPIVYSVKTKEIR 303
Cdd:cd15418 250 VVALFYTVVN-------PLLNPLIYSLRNKDVK 275
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
35-303 1.80e-32

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 121.49  E-value: 1.80e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHT-PMYLFLSMLSMADLGLSASTLPSMVAVFL-LGQRLIGAAACFMQLFFIHTFSVI 112
Cdd:cd15941   9 LIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLtLSGRTISFEGCVVQLYAFHFLAST 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 113 ESAILLAMAFDRCVAIREPLRYATILTTR---RIGAIGLAVVVRSAALHLPLPVllgRLAFQPVSALSHSYCVHPDVLRL 189
Cdd:cd15941  89 ECFLYTVMAYDRYLAICHPLHYPTAMNRRmcaGLAGGTWATGATHAAIHTSLTF---RLPYCGPCQIAYFFCDIPPVLKL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 190 SCSSTVVNSgfglFVMLSTLGMDA----VLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMihr 265
Cdd:cd15941 166 ACADTTINE----LVILANIGIVAagcfLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYL--- 238
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47578039 266 fgRKKLPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15941 239 --QPSSSQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVK 274
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
33-303 6.18e-31

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 117.20  E-value: 6.18e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  33 ICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVI 112
Cdd:cd15433   7 VLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 113 ESAILLAMAFDRCVAIREPLRYATILTTRRIGAI-------GLAVVVRSAALHLPLPVLLGRLafqpvsaLSHSYCVHPD 185
Cdd:cd15433  87 ECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLasiswlsGFVNSVAQTGLLAERPLCGHRL-------LDHFFCEMPV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 186 VLRLSCSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVS--LSMI 263
Cdd:cd15433 160 FLKLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYtyLQPI 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 47578039 264 HRFGRKKlpaqvYMLLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15433 240 HRYSQAH-----GKFVSLFYTVMTPALNPLIYTLRNKDVK 274
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
35-298 1.67e-30

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 115.74  E-value: 1.67e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15938   9 LAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEM 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILtTRRIGAIGLAVVVRSAALHLPLPVLLG-RLAFQPVSALSHSYCVHPDVLRLSCSS 193
Cdd:cd15938  89 FLLTVMAYDRYVAICKPLHYTTIM-SRRLCWVLVAASWAGGFLHSIVQTLLTiQLPFCGPNQVNNFFCDVPPVIKLACTD 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 194 TVVNSgfglFVMLSTLGMDA----VLILLSYVLILktvLSIASNAERLKAFNTCISHICAVLLFYTPLVSLsmihrFGRK 269
Cdd:cd15938 168 TCVTE----LLMVSNSGLIStvcfVVLVTSYTTIL---VTIRSTEGRRKALSTCASHLMVVTLFFGPCIFI-----YARP 235
                       250       260
                ....*....|....*....|....*....
gi 47578039 270 KLPAQVYMLLSYLHFLMPPMLNPIVYSVK 298
Cdd:cd15938 236 FSTFPVDKHVSVLYNVITPMLNPLIYTLR 264
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
37-298 3.13e-28

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 109.85  E-value: 3.13e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  37 YILSVLGNIIIMHIVKSVPSL-HTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIESA 115
Cdd:cd15935  11 YAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEML 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 116 ILLAMAFDRCVAIREPLRYATILTTRRIGAIgLAVVVRSAALHLPLP-VLLGRLAFQPVSALSHSYCVHPDVLRLSCSST 194
Cdd:cd15935  91 LLTLMAYDRYVAICHPLRYLAVMNRQLCIKL-LAACWAGGFLHSATQaALVLRLPFCGPNELDNFYCDVPQVIKLACMDT 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 -------VVNSGFGLFVMLSTLgmdavliLLSYVLILKTVLSIASNAeRLKAFNTCISHICAVLLFYTP--LVSLSMIHR 265
Cdd:cd15935 170 yvvevlmVANSGLLSLVCFLVL-------LVSYGIILTTLRGRFREG-GGKALSTCSSHLTVVSLIFVPciFVYLRPFSS 241
                       250       260       270
                ....*....|....*....|....*....|...
gi 47578039 266 FGRKKLPAQVYMLLSylhflmpPMLNPIVYSVK 298
Cdd:cd15935 242 SSVDKVASVFYTLIT-------PALNPLIYTLR 267
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
35-298 2.04e-24

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 99.81  E-value: 2.04e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15937   9 LFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGAAEM 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCSST 194
Cdd:cd15937  89 FLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIKLACTNT 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 VVNSgfglFVMLSTLGMDAV----LILLSYVLILKTVLSIASNAERlKAFNTCISHICAVLLFYTPLVSLSM--IHRFGR 268
Cdd:cd15937 169 YTVE----LLMFSNSGLVILlcflLLLISYAFLLAKLRTHSSKGKS-KAASTCITHIIIVFVMFGPAIYIYArpFRSFPM 243
                       250       260       270
                ....*....|....*....|....*....|
gi 47578039 269 KKlpaqvymLLSYLHFLMPPMLNPIVYSVK 298
Cdd:cd15937 244 DK-------VVAVFHTVIFPLLNPMIYTLR 266
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
43-295 1.50e-23

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 96.98  E-value: 1.50e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039    43 GNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQR-LIGAAACFMQLFFIHTFSVIESAILLAMA 121
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039   122 FDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPlPVLLGRLAFQPVSalSHSYCVHPDVLRLSCSS--TVVNSG 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLP-PLLFGWTLTVPEG--NVTVCFIDFPEDLSKPVsyTLLISV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039   200 FGLFVMLStlgmdavLILLSYVLILKTVLSIAS-------NAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFGRK-KL 271
Cdd:pfam00001 158 LGFLLPLL-------VILVCYTLIIRTLRKSASkqksserTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDcEL 230
                         250       260
                  ....*....|....*....|....*.
gi 47578039   272 PAQVYMLLSYLHFLMP--PMLNPIVY 295
Cdd:pfam00001 231 SRLLDKALSVTLWLAYvnSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
30-298 3.74e-23

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 96.20  E-value: 3.74e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  30 AIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTF 109
Cdd:cd00637   2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 110 SVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPvsalshsycvhPDVLRL 189
Cdd:cd00637  82 LLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGG-----------YCCCCL 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 190 SCSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVL--------------SIASNAERLKAFNTCISHICAVLLFYT 255
Cdd:cd00637 151 CWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRrhrrrirssssnssRRRRRRRERKVTKTLLIVVVVFLLCWL 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 47578039 256 PLVSLSMIHRFGRK--KLPAQVYMLLSYLHFLmPPMLNPIVYSVK 298
Cdd:cd00637 231 PYFILLLLDVFGPDpsPLPRILYFLALLLAYL-NSAINPIIYAFF 274
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
28-303 9.31e-16

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 75.68  E-value: 9.31e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  28 WTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIH 107
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 108 TFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPlPVLLGRlaFQPVSALSHSYCVHpdvl 187
Cdd:cd14967  81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLP-PLVGWR--DETQPSVVDCECEF---- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 188 rlscsstVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVlsiasnAERLKAFNTCISHICAVLLFYTPLVSLSMIHRF- 266
Cdd:cd14967 154 -------TPNKIYVLVSSVISFFIPLLIMIVLYARIFRVA------RRELKAAKTLAIIVGAFLLCWLPFFIIYLVSAFc 220
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47578039 267 GRKKLPAQVYMLLSYLHFLmPPMLNPIVYSVKTKEIR 303
Cdd:cd14967 221 PPDCVPPILYAVFFWLGYL-NSALNPIIYALFNRDFR 256
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
28-303 3.81e-11

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 62.61  E-value: 3.81e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  28 WTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIH 107
Cdd:cd14969   2 VLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 108 TFSVIESAILLAMAFDRCVAIREPLRYATIltTRRIGAIGLAVVVRSAALhLPLPVLLGRLAFQpvsalshsycvhPDVL 187
Cdd:cd14969  82 FLGLVSISTLAALAFERYLVIVRPLKAFRL--SKRRALILIAFIWLYGLF-WALPPLFGWSSYV------------PEGG 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 188 RLSCS-----STVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERL--------------KAFNTCISHIC 248
Cdd:cd14969 147 GTSCSvdwysKDPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRknsaitkrtkkaekKVAKMVLVMIV 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47578039 249 AVLLFYTPLVSLSMIHRFGRKKLPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd14969 227 AFLIAWTPYAVVSLYVSFGGESTIPPLLATIPALFAKSSTIYNPIIYVFMNKQFR 281
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
35-204 5.46e-10

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 59.29  E-value: 5.46e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15065   8 LIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASI 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALH-LPLPVLLGRLAFQPVSALSHSYCVHPD-VLRLSCS 192
Cdd:cd15065  88 LNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISfLPIHLGWHRLSQDEIKGLNHASNPKPScALDLNPT 167
                       170
                ....*....|..
gi 47578039 193 STVVNSGFGLFV 204
Cdd:cd15065 168 YAVVSSLISFYI 179
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
33-166 4.65e-09

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 56.57  E-value: 4.65e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  33 ICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVI 112
Cdd:cd15083   7 ILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIM 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 47578039 113 ESAILLAMAFDRCVAIREPLRYATILTTRRigAIGLAVVVRSAALHLPLPVLLG 166
Cdd:cd15083  87 SINTLAAIAVDRYLVITRPMKASVRISHRR--ALIVIAVVWLYSLLWVLPPLFG 138
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
34-303 5.71e-09

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 55.94  E-value: 5.71e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  34 CLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLlgQRLIGAAACFMQLFFIHTFSVIE 113
Cdd:cd15070   8 ILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSL--GVTIHFYSCLFMSCLLVVFTHAS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 114 SAILLAMAFDRCVAIREPLRYATILTTRRI-GAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSyCVHPDVLRLscs 192
Cdd:cd15070  86 IMSLLAIAVDRYLRVKLTVRYRIVTTQRRIwLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTTPLQ-CQFTSVMRM--- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 193 STVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAER----LKAFNTCISHICAVLLFYTPLVSLSMIH--RF 266
Cdd:cd15070 162 DYMVYFSFFTWILIPLVIMCALYVDIFYIIRNKLSQNATGFRETgafyGREFKTAKSLALVLFLFAVCWLPLSIINcvVY 241
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47578039 267 GRKKLPaQVYMLLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15070 242 FNPKVP-KIALYLGILLSHANSMMNPIVYACKIKKFK 277
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
29-166 2.86e-08

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 53.97  E-value: 2.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  29 TAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLffihT 108
Cdd:cd15060   3 TTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWL----T 78
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47578039 109 FSVI--ESAI--LLAMAFDRCVAIREPLRYATILTTRRIgaIGLAVVVRSAALHLPLPVLLG 166
Cdd:cd15060  79 CDILccTASIlnLCAIALDRYWAIHDPINYAQKRTLKRV--LLMIVVVWALSALISVPPLIG 138
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
34-229 4.94e-08

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 53.37  E-value: 4.94e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  34 CLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMqLFFIHTFSVIE 113
Cdd:cd14993   8 VVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKA-VPYLQGVSVSA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 114 SAI-LLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVllgrlafqpVSALSHSYCVHPDVLRLSC- 191
Cdd:cd14993  87 SVLtLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLV---------VYELEEIISSEPGTITIYIc 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 47578039 192 ----SSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLS 229
Cdd:cd14993 158 tedwPSPELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWR 199
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
34-161 6.64e-08

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 53.06  E-value: 6.64e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  34 CLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPS-MVAVFLLGQRLIGAAACFMQLFFIHTFSVI 112
Cdd:cd14997   8 GVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVaLVETWAREPWLLGEFMCKLVPFVELTVAHA 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47578039 113 ESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPL 161
Cdd:cd14997  88 SVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPV 136
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
34-306 1.46e-07

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 51.88  E-value: 1.46e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  34 CLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLgLSASTLPSMVAVFLLGQRLI-GAAACFMQ--LFFIHTFS 110
Cdd:cd14982   8 SLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADL-LFVLTLPFRIYYYLNGGWWPfGDFLCRLTglLFYINMYG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 111 VIesAILLAMAFDRCVAIREPLRYATILTTRRigAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLS 190
Cdd:cd14982  87 SI--LFLTCISVDRYLAVVHPLKSRRLRRKRY--AVGVCAGVWILVLVASVPLLLLRSTIAKENNSTTCFEFLSEWLASA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 191 CSSTVVNSGFGLFVMLstlgmdaVLILLSYVLILKTVLSIASNA----ERLKAFNTCISHICAVLLFYTPLVSLSMIHRF 266
Cdd:cd14982 163 APIVLIALVVGFLIPL-------LIILVCYSLIIRALRRRSKQSqksvRKRKALRMILIVLAVFLVCFLPYHVTRILYLL 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 47578039 267 GRKKLPAQVYMLLSYLHFL--------MPPMLNPIVYSVKTKEIRVRI 306
Cdd:cd14982 236 VRLSFIADCSARNSLYKAYritlclasLNSCLDPLIYYFLSKTFRKRL 283
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
36-181 1.84e-07

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 51.74  E-value: 1.84e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  36 IYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFiHTFSVIESA 115
Cdd:cd15202  10 IIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFA-QYCSVHVSA 88
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47578039 116 I-LLAMAFDRCVAIREPLRYAtilTTRRIGAIGLAVV-VRSAALHLPLPVLLGRLAFQPVSALSHSYC 181
Cdd:cd15202  89 YtLTAIAVDRYQAIMHPLKPR---ISKTKAKFIIAVIwTLALAFALPHAICSKLETFKYSEDIVRSLC 153
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
38-146 2.73e-07

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 51.09  E-value: 2.73e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  38 ILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQlffiHTFSVIESAI- 116
Cdd:cd15354  12 IISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVR----HIDNVFDSLIc 87
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 47578039 117 ---------LLAMAFDRCVAIREPLRYATILTTRRIGAI 146
Cdd:cd15354  88 isvvasmcsLLAIAVDRYVTIFYALRYHNIMTVRRAGII 126
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
28-156 3.20e-07

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 50.91  E-value: 3.20e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  28 WTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFfIH 107
Cdd:cd15058   2 GLLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTS-VD 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47578039 108 TFSVIES-AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAA 156
Cdd:cd15058  81 VLCVTASiETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSAL 130
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
33-162 3.24e-07

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 50.70  E-value: 3.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  33 ICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSA-STLPSM---VAVFLLGQRLIGAAACFMQLFFIHt 108
Cdd:cd15196   7 LATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALfNVLPQLiwdITYRFYGGDLLCRLVKYLQVVGMY- 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 47578039 109 fsvIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVvrsAALHLPLP 162
Cdd:cd15196  86 ---ASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAIAWV---LSLLLSIP 133
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
34-146 3.29e-07

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 50.72  E-value: 3.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  34 CLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVfllgqrLIGAAACFMQLFFIHTFSVI- 112
Cdd:cd14968   8 VLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILI------SLGLPTNFHGCLFMACLVLVl 81
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 47578039 113 -ESAI--LLAMAFDRCVAIREPLRYATILTTRRIGAI 146
Cdd:cd14968  82 tQSSIfsLLAIAIDRYLAIKIPLRYKSLVTGRRAWGA 118
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
38-157 3.98e-07

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 50.28  E-value: 3.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039    38 ILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSmvAVFLLGQRLIGAAACFMQLFFIHTFSVIESAIL 117
Cdd:pfam10320   2 VIGLFGNVLMIHLTFRKKKLRSKCSILICVQCIAHLICLCGEIVF--VVLLFTGTQLTRNECFWMISFYIFGQTAQGPLM 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 47578039   118 LAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAAL 157
Cdd:pfam10320  80 LMIGIDRLIAVKFPIFYRLLSSSKYLFIQLIFPVIYSSFI 119
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
32-164 4.03e-07

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 50.71  E-value: 4.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  32 PICLIYILSVLGNII-IMHIVKSVPSLH-TPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTF 109
Cdd:cd14981   6 PPALMFVFGVLGNLLaLIVLARSSKSHKwSVFYRLVAGLAITDLLGILLTSPVVLAVYASNFEWDGGQPLCDYFGFMMSF 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47578039 110 SVIESA-ILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLpLPVL 164
Cdd:cd14981  86 FGLSSLlIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIAS-LPLL 140
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
30-160 4.44e-07

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 50.31  E-value: 4.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  30 AIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTF 109
Cdd:cd15321  10 AAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLF 89
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 47578039 110 SVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLP 160
Cdd:cd15321  90 CTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLP 140
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
30-303 4.99e-07

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 50.06  E-value: 4.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  30 AIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTF 109
Cdd:cd15213   4 AILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWFF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 110 SVIESAILLAMAFDRCVAIrepLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPvsalSHSYCVhpdvlrL 189
Cdd:cd15213  84 VLEGVAILLIISVDRYLII---VQRQDKLNPHRAKILIAVSWVLSFCVSFPPLVGWGKYEFPP----RAPQCV------L 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 190 SCSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIasnaeRLKAFNTCISHICAVLLFYTPLVSLSMIHRFGRK 269
Cdd:cd15213 151 GYTESPADRIYVVLLLVAVFFIPFLIMLYSYFCILNTVRSF-----KTRAFTTILILFIGFSVCWLPYTVYSLLSVFSRY 225
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47578039 270 K----LPAQVYMLLSYLHflmpPMLNPIVYSVKTKEIR 303
Cdd:cd15213 226 SssfyVISTCLLWLSYLK----SAFNPVIYCWRIKKFR 259
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
38-146 7.67e-07

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 49.52  E-value: 7.67e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  38 ILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAaacfmQLFFIHTFSVIESAI- 116
Cdd:cd15353  12 IVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLNGNDTDA-----QSFTVNIDNVIDSVIc 86
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 47578039 117 ---------LLAMAFDRCVAIREPLRYATILTTRRIGAI 146
Cdd:cd15353  87 ssllasicsLLSIAVDRYFTIFYALQYHNIMTVRRAGVI 125
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
35-163 7.90e-07

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 49.67  E-value: 7.90e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLP-SMVAVFLLGQRLIGAAACFMqLFFIHTFSVIE 113
Cdd:cd15392   9 TIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPfSFIALLILQYWPFGEFMCPV-VNYLQAVSVFV 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47578039 114 SAI-LLAMAFDRCVAIREPLRyatILTTRRIGAIGLAVV-VRSAALHLPLPV 163
Cdd:cd15392  88 SAFtLVAISIDRYVAIMWPLR---PRMTKRQALLLIAVIwIFALATALPIAI 136
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
38-146 1.12e-06

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 49.02  E-value: 1.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  38 ILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQlffiHTFSVIESAI- 116
Cdd:cd15103  12 IVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQ----HIDNVIDSMIc 87
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 47578039 117 ---------LLAMAFDRCVAIREPLRYATILTTRRIGAI 146
Cdd:cd15103  88 ssllasicsLLAIAVDRYITIFYALRYHSIMTVRRAGVI 126
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
35-160 1.14e-06

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 49.17  E-value: 1.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMhIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLL---GQRLIGAAACFMQL--FFIHTF 109
Cdd:cd14978   9 VICIFGIIGNILNL-VVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIAdysSSFLSYFYAYFLPYiyPLANTF 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 47578039 110 SVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLP 160
Cdd:cd14978  88 QTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLP 138
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
35-166 1.47e-06

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 48.78  E-value: 1.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLlgqrliGAAACFMQLFFIHTFSVI-- 112
Cdd:cd15069   9 IIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISL------GFCTDFHSCLFLACFVLVlt 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47578039 113 ESAI--LLAMAFDRCVAIREPLRYATILTTRRigAIGLAVVVRSAALHLPLPVLLG 166
Cdd:cd15069  83 QSSIfsLLAVAVDRYLAIKVPLRYKSLVTGKR--ARGVIAVLWVLAFGIGLTPFLG 136
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
35-146 1.66e-06

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 48.78  E-value: 1.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFllgqrlIGAAACFMQLFFIHTFSVI-- 112
Cdd:cd15068   9 AIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS------TGFCAACHGCLFIACFVLVlt 82
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 47578039 113 ESAI--LLAMAFDRCVAIREPLRYATILTTRRIGAI 146
Cdd:cd15068  83 QSSIfsLLAIAIDRYIAIRIPLRYNGLVTGTRAKGI 118
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
35-152 1.73e-06

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 48.41  E-value: 1.73e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15299  12 ILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASV 91
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGA-IGLAVVV 152
Cdd:cd15299  92 MNLLVISFDRYFSITRPLTYRAKRTTKRAGVmIGLAWVI 130
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
33-237 2.51e-06

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 48.18  E-value: 2.51e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  33 ICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVI 112
Cdd:cd15336   7 ILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGIT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 113 ESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSaaLHLPLPVLLGRLAFQpvsalshsycvhPDVLRLSCS 192
Cdd:cd15336  87 SMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYS--LAWSLPPLFGWSAYV------------PEGLLTSCT 152
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 47578039 193 -----STVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERL 237
Cdd:cd15336 153 wdymtFTPSVRAYTMLLFCFVFFIPLGIIIYCYLFIFLAIRSTGREVQKL 202
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
31-167 2.71e-06

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 48.12  E-value: 2.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  31 IPICLIYIL----SVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPsmVAVFLLGQR---LIGAAACFMQL 103
Cdd:cd14979   1 VLVTAIYVAifvvGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLP--VELYNFWWQypwAFGDGGCKLYY 78
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47578039 104 FFIHTFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGR 167
Cdd:cd14979  79 FLFEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGI 142
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
33-160 2.84e-06

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 48.01  E-value: 2.84e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  33 ICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVI 112
Cdd:cd15323   7 VGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTS 86
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 47578039 113 ESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLP 160
Cdd:cd15323  87 SIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFP 134
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
36-142 2.99e-06

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 47.81  E-value: 2.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  36 IYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIESA 115
Cdd:cd15050  10 ISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIF 89
                        90       100
                ....*....|....*....|....*..
gi 47578039 116 ILLAMAFDRCVAIREPLRYATILTTRR 142
Cdd:cd15050  90 SLFILCIDRYRSVQQPLKYLKYRTKTR 116
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
33-164 3.03e-06

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 47.98  E-value: 3.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  33 ICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAAC--FMQLFFIHTFS 110
Cdd:cd15959   7 LSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCelWTSVDVLCVTA 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 47578039 111 VIESaiLLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLpLPVL 164
Cdd:cd15959  87 SIET--LCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISF-LPIM 137
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
36-154 4.44e-06

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 47.10  E-value: 4.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  36 IYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIESA 115
Cdd:cd15062  10 FILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIM 89
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 47578039 116 ILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRS 154
Cdd:cd15062  90 SLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLS 128
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
35-225 5.04e-06

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 47.29  E-value: 5.04e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15096   9 LIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIgaIGLAVVVRSAALHLPLPVLLG-RLAFQPVSALSHSYCVHPDVLRLScss 193
Cdd:cd15096  89 YTLVLMSLDRYLAVVHPITSMSIRTERNT--LIAIVGIWIVILVANIPVLFLhGVVSYGFSSEAYSYCTFLTEVGTA--- 163
                       170       180       190
                ....*....|....*....|....*....|..
gi 47578039 194 tvVNSGFGLFVMLSTLgMDAVLILLSYVLILK 225
Cdd:cd15096 164 --AQTFFTSFFLFSYL-IPLTLICVLYMLMLR 192
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
35-160 5.16e-06

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 46.86  E-value: 5.16e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15322   9 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSI 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLP 160
Cdd:cd15322  89 VHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFP 134
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
34-304 5.82e-06

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 47.17  E-value: 5.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  34 CLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIE 113
Cdd:cd15978   8 SLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSVS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 114 SAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCvhpdvlRLSCSS 193
Cdd:cd15978  88 TFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPFTRINNSTGNMC------RLLWPN 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 194 TVVNSGFGLFVMLSTLGMDAVLILLSYVLI-LKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSMIHRFGRKK-- 270
Cdd:cd15978 162 DVTQQSWYIFLLLILFLIPGIVMMTAYGLIsLELYRGIKFLMAKKRVIRMLIVIVILFFLCWTPIFSANAWRAFDTRSad 241
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47578039 271 -----LPAQVYMLLSYlhflMPPMLNPIVYSVKTKEIRV 304
Cdd:cd15978 242 rllsgAPISFIHLLSY----TSACVNPIIYCFMNKRFRM 276
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
28-230 8.63e-06

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 46.34  E-value: 8.63e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  28 WTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIH 107
Cdd:cd15054   2 WVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 108 TFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSA-ALHLPLPVLLGRLAFQPVSALSHSYCVHPD- 185
Cdd:cd15054  82 MCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAAlASFLPIELGWHELGHERTLPNLTSGTVEGQc 161
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 47578039 186 VLRLSCSSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSI 230
Cdd:cd15054 162 RLLVSLPYALVASCLTFFLPSGAICFTYCRILLAARKALKASLTL 206
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
28-164 8.89e-06

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 46.46  E-value: 8.89e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  28 WTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLP-SMVAVFLLGQRLIGAAACFMQLFFI 106
Cdd:cd15304   2 WPALLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVWIYLD 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 47578039 107 HTFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVL 164
Cdd:cd15304  82 VLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVF 139
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
35-306 1.42e-05

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 45.73  E-value: 1.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMqLFFIHTFSVIES 114
Cdd:cd15001   8 ITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKA-VAYLQLLSFICS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AI-LLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPdvlrlsCSS 193
Cdd:cd15001  87 VLtLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHCQKA------WPS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 194 TVVNSGFGLFVMLSTLGMDAVLILLSYVLIlktvlsiasnaERLKAFNTCISHICAVLLFYTPLVSLSMIHRF------- 266
Cdd:cd15001 161 TLYSRLYVVYLAIVIFFIPLIVMTFAYARD-----------TRKQVIKMLISVVVLFAVCWGPLLIDNLLVSFdvistlh 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47578039 267 -GRKKLPAQVYMLLSYLHflmpPMLNPIVYSVKTKEIRVRI 306
Cdd:cd15001 230 tQALKYMRIAFHLLSYAN----SCINPIIYAFMSKNFRSSF 266
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
30-303 1.67e-05

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 45.77  E-value: 1.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  30 AIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLI-GAAACFMQLFFIHT 108
Cdd:cd15337   4 GIYIAIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNGFPLKTISSFNKKWIwGKVACELYGFAGGI 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 109 FSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAfqpvsalshsycvhPDVLR 188
Cdd:cd15337  84 FGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRYV--------------PEGFQ 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 189 LSC-----SSTVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLS----------------IASNAER----LKAFNTC 243
Cdd:cd15337 150 TSCtfdylSRDLNNRLFILGLFIFGFLCPLLIIIFCYVNIIRAVRNhekemtqtaksgmgkdTEKNDARkkaeIRIAKVA 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47578039 244 ISHICAVLLFYTPLVSLSMIHRFGRKklpaqvyMLLSYLHFLMPPML-------NPIVYSVKTKEIR 303
Cdd:cd15337 230 IILISLFLLSWTPYAVVALLGQFGPA-------YWITPYVSELPVMFakasaiyNPIIYALSHPKFR 289
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
27-165 2.22e-05

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 45.36  E-value: 2.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  27 CWtAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFI 106
Cdd:cd15390   2 LW-SIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVA 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47578039 107 HTFSVIESAILLAMAFDRCVAIREPLRyatilttRRIG---AIGLAVVVRSAALHLPLPVLL 165
Cdd:cd15390  81 ITTVAASVFTLMAISIDRYIAIVHPLR-------PRLSrrtTKIAIAVIWLASFLLALPQLL 135
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
28-164 2.75e-05

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 44.90  E-value: 2.75e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  28 WTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLP-SMVAVFLLGQRLIGAAACFMQLFFI 106
Cdd:cd15305   2 WPALLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPvSLIAILYDYAWPLPRYLCPIWISLD 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 47578039 107 HTFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVL 164
Cdd:cd15305  82 VLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMPIPVI 139
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
35-149 3.00e-05

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 44.57  E-value: 3.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd17790   9 ILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASV 88
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIG-AIGLA 149
Cdd:cd17790  89 MNLLIISFDRYFSITRPLTYRAKRTPRRAAiMIGLA 124
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
30-161 3.02e-05

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 44.64  E-value: 3.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  30 AIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPsmVAVFLL---GQRLIGAAACFmqlFFI 106
Cdd:cd15053   4 ALFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMP--FAVYVEvngGKWYLGPILCD---IYI 78
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 47578039 107 hTFSVIESAI----LLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPL 161
Cdd:cd15053  79 -AMDVMCSTAsifnLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPL 136
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
38-142 3.85e-05

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 44.50  E-value: 3.85e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  38 ILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIESAIL 117
Cdd:cd15325  12 LFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSL 91
                        90       100
                ....*....|....*....|....*
gi 47578039 118 LAMAFDRCVAIREPLRYATILTTRR 142
Cdd:cd15325  92 CIISIDRYIGVSYPLRYPSIMTERR 116
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
38-142 4.10e-05

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 44.11  E-value: 4.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  38 ILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIESAIL 117
Cdd:cd15326  12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSL 91
                        90       100
                ....*....|....*....|....*
gi 47578039 118 LAMAFDRCVAIREPLRYATILTTRR 142
Cdd:cd15326  92 CAISIDRYIGVRHSLQYPTIVTRKR 116
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
35-133 4.26e-05

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 44.25  E-value: 4.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15389   9 IIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVYVST 88
                        90
                ....*....|....*....
gi 47578039 115 AILLAMAFDRCVAIREPLR 133
Cdd:cd15389  89 LTLTAIALDRHRVILHPLK 107
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
34-164 4.30e-05

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 44.21  E-value: 4.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  34 CLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVie 113
Cdd:cd14972   6 IVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLA-- 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47578039 114 SAI-LLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLpLPVL 164
Cdd:cd14972  84 SAYsLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAL-LPVL 134
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
35-152 4.63e-05

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 44.25  E-value: 4.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15300   9 VVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYVASNASV 88
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIG-AIGLAVVV 152
Cdd:cd15300  89 MNLLVISFDRYFSITRPLTYRAKRTPKRAGiMIGLAWLI 127
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
38-142 4.69e-05

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 44.11  E-value: 4.69e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  38 ILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQlffiHTFSVIESAI- 116
Cdd:cd15352  12 IVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQ----HMDNVFDSMIc 87
                        90       100       110
                ....*....|....*....|....*....|....*
gi 47578039 117 ---------LLAMAFDRCVAIREPLRYATILTTRR 142
Cdd:cd15352  88 islvasicnLLAIAVDRYVTIFYALRYHSIMTVRK 122
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
34-306 5.13e-05

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 44.31  E-value: 5.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  34 CLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAAC----FMQLFFIHtf 109
Cdd:cd15195   8 WVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCrvmmFLKQFGMY-- 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 110 svIESAILLAMAFDRCVAIREPLryaTILTTRRIGAIGLAVV-VRSAALHLPLPVLLGRLAFQP-----VSALSHSYCVH 183
Cdd:cd15195  86 --LSSFMLVVIALDRVFAILSPL---SANQARKRVKIMLTVAwVLSALCSIPQSFIFSVLRKMPeqpgfHQCVDFGSAPT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 184 PDVLRLscsstvvnsgFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFN---TCISHI------------- 247
Cdd:cd15195 161 KKQERL----------YYFFTMILSFVIPLIITVTCYLLILFEISKMAKRARDTPISNrrrSRTNSLerarmrtlrmtal 230
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47578039 248 --CAVLLFYTPLVSLSMIHRF---GRKKLPA--QVYM-LLSYLHflmpPMLNPIVYSVKTKEIRVRI 306
Cdd:cd15195 231 ivLTFIVCWGPYYVLGLWYWFdkeSIKNLPPalSHIMfLLGYLN----PCLHPIIYGVFMKEIRNWI 293
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
35-148 5.63e-05

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 44.05  E-value: 5.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIV-KSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIE 113
Cdd:cd15097   9 LIFLLGTVGNSLVLAVLlRSGQSGHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLTMYAS 88
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 47578039 114 SAILLAMAFDRCVAIREPLRYATILTTRR-IGAIGL 148
Cdd:cd15097  89 SFTLAAVSVDRYLAIRYPLRSRELRTPRNaVAAIAL 124
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
38-160 5.95e-05

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 43.80  E-value: 5.95e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  38 ILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIESAIL 117
Cdd:cd15297  12 LVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNL 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 47578039 118 LAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLP 160
Cdd:cd15297  92 LIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAP 134
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
33-165 6.19e-05

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 44.12  E-value: 6.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  33 ICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAAC--FMQLFFIHTFS 110
Cdd:cd15958   7 MALIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCelWTSVDVLCVTA 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47578039 111 VIESaiLLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLpLPVLL 165
Cdd:cd15958  87 SIET--LCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSF-LPIMM 138
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
30-160 6.26e-05

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 43.97  E-value: 6.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  30 AIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTF 109
Cdd:cd15012   3 IILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLS 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 47578039 110 SVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLP 160
Cdd:cd15012  83 YTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTP 133
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
29-160 7.45e-05

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 43.48  E-value: 7.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  29 TAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQL---FF 105
Cdd:cd15059   3 ISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLaldVL 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47578039 106 IHTFSVIEsaiLLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLP 160
Cdd:cd15059  83 FCTASIVN---LCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLP 134
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
28-310 8.33e-05

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 43.40  E-value: 8.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  28 WTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIH 107
Cdd:cd15307   2 YWALLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 108 TFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRlafQPVSALSHSYCVHPDVL 187
Cdd:cd15307  82 LFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSK---DHASVLVNGTCQIPDPV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 188 rlscsSTVVNSGFGLFVMLstlgmdaVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLF-----YTPLVSLSM 262
Cdd:cd15307 159 -----YKLVGSIVCFYIPL-------GVMLLTYCLTVRLLARQRSRHGRIIRLEQKATKVLGVVFFtfvilWSPFFVLNL 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 47578039 263 IHRFG---RKKLPAQVYMLLSYLHFlMPPMLNPIVYSVKTKEIRVRILKML 310
Cdd:cd15307 227 LPTVCaecEERISHWVFDVVTWLGY-ASSMVNPIFYTIFNKVFRQAFKKVL 276
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
34-163 8.72e-05

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 43.36  E-value: 8.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  34 CLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMqLFFIHTFSVIE 113
Cdd:cd15203   8 GLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKL-VPSLQGVSIFV 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 47578039 114 SAI-LLAMAFDRCVAIREPLRyaTILTTRRIGAIGLAVVVRSAALHLPLPV 163
Cdd:cd15203  87 STLtLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLLLSLPLAI 135
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
35-182 9.50e-05

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 43.18  E-value: 9.50e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSL--HTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVI 112
Cdd:cd15098   9 LIFCLGVLGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHYFFTVSMLV 88
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 113 ESAILLAMAFDRCVAIREPLRYATIlTTRRIGAIGLaVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCV 182
Cdd:cd15098  89 SIFTLVAMSVDRYIAVVHSRTSSSL-RTRRNALLGV-LVIWVLSLAMASPVAVHQDLVHHWTASNQTFCW 156
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
38-156 9.60e-05

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 43.24  E-value: 9.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  38 ILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLF-----FIHTFSVI 112
Cdd:cd15351  12 LVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMdnvidTMICSSVV 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47578039 113 ES-AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAA 156
Cdd:cd15351  92 SSlSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTV 136
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
35-166 9.74e-05

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 43.13  E-value: 9.74e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15066   8 LIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFSTASI 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIgAIGLAVVVRSAALHLPLPVLLG 166
Cdd:cd15066  88 LHLCCISVDRYYAIVQPLEYPSKMTKRRV-AIMLANVWISPALISFLPIFLG 138
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
28-295 9.92e-05

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 43.42  E-value: 9.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  28 WTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIH 107
Cdd:cd15074   2 IIGIYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 108 TFSVIESAILLAMAFDRCVAIREPlRYATILTTRRIgaIGLAVVVRSAALHLPLPVLLGrlafqpvsalSHSYcvHPDVL 187
Cdd:cd15074  82 LFGCCSINTLTAISIYRYLKICHP-PYGPKLSRRHV--CIVIVAIWLYALFWAVAPLVG----------WGSY--GPEPF 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 188 RLSCS-------STVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTV----LSIASNAERLKAFNTCISH-------ICA 249
Cdd:cd15074 147 GTSCSidwtgasASVGGMSYIISIFIFCYLLPVLIIVFSYVKIIRKVkssrKRVAGFDSRSKRQHKIERKvtkvavlICA 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47578039 250 V-LLFYTPLVSLSMIHRFGRK-KLPAQVYMLlsylhflmPP-------MLNPIVY 295
Cdd:cd15074 227 GfLIAWTPYAVVSMWSAFGSPdSVPILASIL--------PAlfaksscMYNPIIY 273
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
35-303 1.16e-04

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 43.09  E-value: 1.16e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15051   9 VIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDVMLCTASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLpLPVLLG----RLAFQPVSalshsycvHPDVLRLS 190
Cdd:cd15051  89 LNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSF-LPIHLGwntpDGRVQNGD--------TPNQCRFE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 191 csstvVNSGFGLFVMLSTLGMDAVLILLSYVLILKTV---------LSIASNAERLKAFNTCISH---------ICAVLL 252
Cdd:cd15051 160 -----LNPPYVLLVAIGTFYLPLLIMCGVYLRIFRIAreqakrinaLTPASTANSSKSAATAREHkatvtlaavLGAFII 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 47578039 253 FYTPLVSLSMIHRFGRKKLPAQVYMLLSYLHFLmPPMLNPIVYSVKTKEIR 303
Cdd:cd15051 235 CWFPYFTYFTYRGLCGDNINETALSVVLWLGYA-NSALNPILYAFLNRDFR 284
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
30-160 1.66e-04

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 42.26  E-value: 1.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  30 AIPICLIYILSVLGNIIIMHIVKSVPSLHTPM-YLFLSmLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMqlfFIhT 108
Cdd:cd15329   4 GIVLLIIILGTVVGNALVIIAVCLVKKLRTPSnYLIVS-LAVSDLLVALLVMPLAIIYELSGYWPFGEILCDV---WI-S 78
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47578039 109 FSVI--ESAI--LLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLP 160
Cdd:cd15329  79 FDVLlcTASIlnLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIP 134
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
31-167 1.98e-04

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 42.17  E-value: 1.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  31 IPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFS 110
Cdd:cd15324   5 LVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFC 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47578039 111 VIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPlPVLLGR 167
Cdd:cd15324  85 TSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFP-PLLMTK 140
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
36-303 2.22e-04

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 42.21  E-value: 2.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  36 IYILS-VLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15327   9 IFILMaIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIglAVVVRSAALHLPLPVLLGRLAFQPvsalshsycvhPDVlrlSCSST 194
Cdd:cd15327  89 LSLCVISVDRYVGVKHSLKYPTIMTERKAGVI--LVLLWVSSMVISIGPLLGWKEPPP-----------PDE---SICSI 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 VVNSGFGLFVMLSTLGMDAVLILLSY--VLILKTVLSIASNAERLKAFNTCISHICAVLLFYT-PLVSLsmihrFGRKKL 271
Cdd:cd15327 153 TEEPGYALFSSLFSFYLPLMVILVMYfrVYVVALKFSREKKAAKTLAIVVGVFILCWFPFFFVlPLGSF-----FPALKP 227
                       250       260       270
                ....*....|....*....|....*....|..
gi 47578039 272 PAQVYMLLSYLHFLmPPMLNPIVYSVKTKEIR 303
Cdd:cd15327 228 SEMVFKVIFWLGYF-NSCVNPIIYPCSSKEFK 258
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
33-304 2.48e-04

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 42.10  E-value: 2.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  33 ICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQL---FFIHTF 109
Cdd:cd15063   7 LTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLavdVWMCTA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 110 SVIEsaiLLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCvhpdvlrl 189
Cdd:cd15063  87 SILN---LCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGKDGIMDYSGSSSL-------- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 190 SCSSTVVNS-GFGLFVMLSTLGMDAVLILLSYVLILKtvlsiASNAErLKAFNTCISHICAVLLFYTPLVSLSMIHRFGR 268
Cdd:cd15063 156 PCTCELTNGrGYVIYSALGSFYIPMLVMLFFYFRIYR-----AARME-TKAAKTVAIIVGCFIFCWLPFFTVYLVRAFCE 229
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47578039 269 KKLPAQVYMLLSYLHFLMPPMlNPIVYSVKTKEIRV 304
Cdd:cd15063 230 DCIPPLLFSVFFWLGYCNSAL-NPCIYALFSRDFRF 264
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
30-303 2.86e-04

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 41.63  E-value: 2.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  30 AIPICL--IYILSVLGNIIIMHIV-----KSVPSLHTPMYLflsMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQ 102
Cdd:cd15002   1 LVPILLgvICLLGFAGNLMVIGILlnnarKGKPSLIDSLIL---NLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTA 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 103 LFFIHTFSVIESAILLAMAFDRCVAIREPLRYATILtTRRIGAIGLAVVVRSAALHLPLpvllgrLAFQPVSALSHSYCV 182
Cdd:cd15002  78 DWFGHACMAAKSFTIAVLAKACYMYVVNPTKQVTIK-QRRITAVVASIWVPACLLPLPQ------WLFRTVKQSEGVYLC 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 183 HPDVLRLSCSSTVVnsgFGLFVMLSTLGMDAVLILLSYVLILKTV--LSIASNAERLKAFNTCISHICAVLLFYTPLV-- 258
Cdd:cd15002 151 ILCIPPLAHEFMSA---FVKLYPLFVFCLPLTFALFYFWRAYGQCqrRGTKTQNLRNQIRSRKLTHMLLSVVLAFTILwl 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 47578039 259 -----SLSMIHRFGRKKLPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEIR 303
Cdd:cd15002 228 pewvaWLWLIHIKSSGSSPPQLFNVLAQLLAFSISSVNPIIFLLMSEEFR 277
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
35-304 3.10e-04

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 41.68  E-value: 3.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd14971   9 LIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSMHASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRlaFQPVSAlSHSYCVHpdvlrlSCSST 194
Cdd:cd14971  89 FTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRL--RNYTPG-NRTVCSE------AWPSR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 195 VVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASN------AERLKAFNTCISHICAVLLF--YTPLVSLSMIHRF 266
Cdd:cd14971 160 AHRRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRpvlsegSRRAKRKVTRLVLVVVVLFAacWGPIHAILLLVAL 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 47578039 267 GRKKLPAQVYMLLSYLHFL--MPPMLNPIVYSVKTKEIRV 304
Cdd:cd14971 240 GPFPLTYATYALRIWAHCLaySNSAVNPVLYAFLSEHFRK 279
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
38-297 3.28e-04

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 41.54  E-value: 3.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  38 ILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIESAIL 117
Cdd:cd15298  12 LVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 118 LAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYcvhpdVLRLSCSSTVVN 197
Cdd:cd15298  92 LIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCF-----IQFLSNPAVTFG 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 198 SGFGLFVmlstlgMDAVLILLSYVLIlktvlSIASNAERlKAFNTCISHICAVLLFYTPLVSLSMIHRFGRKKLPAQVYM 277
Cdd:cd15298 167 TAIAAFY------LPVVIMTVLYIHI-----SLASARER-KVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWS 234
                       250       260
                ....*....|....*....|
gi 47578039 278 LLSYLHFLmPPMLNPIVYSV 297
Cdd:cd15298 235 IGYWLCYV-NSTINPACYAL 253
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
34-174 3.61e-04

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 41.49  E-value: 3.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  34 CLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLgLSASTLPsMVAVFLLGQRLIGAAACFMqLFFIHTFSVIE 113
Cdd:cd15178   8 VLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADL-LFALTLP-FWAVSVVKGWIFGTFMCKL-VSLLQEANFYS 84
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47578039 114 SAILLA-MAFDRCVAIrepLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVS 174
Cdd:cd15178  85 GILLLAcISVDRYLAI---VHATRALTQKRHLVKFVCAGVWLLSLLLSLPALLNRDAFKPPN 143
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
30-208 3.63e-04

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 41.57  E-value: 3.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  30 AIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQR-LIGAAACFMqlffIHT 108
Cdd:cd15067   3 GVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGYwLFGRDWCDV----WHS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 109 FSVIESAI----LLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPlPVLLGRLAFQPVSALSHsyCVHP 184
Cdd:cd15067  79 FDVLASTAsilnLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFP-AIAWWRAVDPGPSPPNQ--CLFT 155
                       170       180
                ....*....|....*....|....*.
gi 47578039 185 -DVLRLSCSSTVvnSGFG-LFVMLST 208
Cdd:cd15067 156 dDSGYLIFSSCV--SFYIpLVVMLFT 179
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
35-164 3.80e-04

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 41.47  E-value: 3.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADlGLSASTLPSMVAVFLLGQRLIGAAAC--FMQLFFIHTFSVI 112
Cdd:cd15089   9 VVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSAKYLMETWPFGELLCkaVLSIDYYNMFTSI 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 47578039 113 ESaiLLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVL 164
Cdd:cd15089  88 FT--LTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVM 137
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
38-306 4.12e-04

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 41.26  E-value: 4.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  38 ILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIESAIL 117
Cdd:cd15073  12 IISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 118 LAMAFDRCVAIREPLRYATiLTTRRIGAIGLAVVVrSAALHLPLPVL-LGRLAFQPVSALSHSYCVHPDVLRLSCSSTVV 196
Cdd:cd15073  92 TVVAVDRYLTICRPDLGRK-MTTNTYTVMILLAWT-NAFFWAAMPLVgWASYALDPTGATCTINWRKNDSSFVSYTMSVI 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 197 NSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFN-TCISHICAVLLFYTPLVSLSMIHRFGR-KKLPAQ 274
Cdd:cd15073 170 VVNFIVPLAVMFYCYYNVSRFVKKVLASDCLESVNIDWTDQNDVTkMSVIMIVMFLVAWSPYSIVCLWASFGEpKKIPPW 249
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47578039 275 VYmllsylhfLMPPML-------NPIVYSVKTKEIRVRI 306
Cdd:cd15073 250 MA--------IIPPLFaksstfyNPCIYVIANKKFRRAI 280
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
30-303 4.22e-04

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 41.08  E-value: 4.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  30 AIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTF 109
Cdd:cd15214   3 SIAIIIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 110 SVIESAILLAMAFDRCVAIREPLRYATILTTRRigAIGLAVVVRSAALHLPLPVLLGRLAFQpvsalshsycvhPDVLRL 189
Cdd:cd15214  83 SSASMLTLGAIAIDRYYAVLYPMVYPMKITGNR--AVLALVYIWLHSLIGCLPPLFGWSSLE------------FDRFKW 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 190 SCSSTV-VNSGFGLFVMLSTLGMDAVLILLSYVLILKTvlsiaSNAERLKAFNTCISHICAVLLFYTP-LVSLSMIHRFG 267
Cdd:cd15214 149 MCVAAWhKEAGYTAFWQVWCALLPFVVMLVCYGFIFRV-----ARANQCKAFITILVVLGAFVTTWGPyMVVISTEALWG 223
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47578039 268 RKKLPAQVYMLLSYLHFlMPPMLNPIVYSVKTKEIR 303
Cdd:cd15214 224 KNSVSPQLETLATWLSF-TSAVCHPLIYGLWNKTVR 258
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
33-133 4.75e-04

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 41.34  E-value: 4.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  33 ICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLglsastlpsMVAVFLLGQRLI--------GAAACFMQLF 104
Cdd:cd15387   7 LALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADL---------VVAVFQVLPQLIwditfrfyGPDFLCRLVK 77
                        90       100       110
                ....*....|....*....|....*....|
gi 47578039 105 FIHTFSVIESA-ILLAMAFDRCVAIREPLR 133
Cdd:cd15387  78 YLQVVGMFASTyMLLLMSIDRCLAICQPLR 107
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
27-166 5.22e-04

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 40.94  E-value: 5.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  27 CWTAIPICLiYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLgLSASTLP-SMVAVFLLGQRLIGAAACFMQLFF 105
Cdd:cd15928   2 AVTAVCSVL-MLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDL-LIFLVLPlDLYRLWRYRPWRFGDLLCRLMYFF 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47578039 106 IHTFSVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLG 166
Cdd:cd15928  80 SETCTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVG 140
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
35-304 5.72e-04

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 41.02  E-value: 5.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACfmQLFFIHTFSVIES 114
Cdd:cd15131   9 LLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWQYRPWNFGDLLC--KLFQFVSESCTYS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AIL--LAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCVHPDVLRLSCS 192
Cdd:cd15131  87 TILniTALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIFVLVGVEHENGTNPIDTNECKATEYAVRSGL 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 193 STVVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKAFNTCISHICAVLLFYTPLVSLSM-IHRFGRKK- 270
Cdd:cd15131 167 LTIMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRRENIGPNASHRDKNNRQTVKMLAVVVFAFVLCWLPFhVGRYLFSKs 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 47578039 271 ---------LPAQVYMLLSYLHFLMPPMLNPIVYSVKTKEIRV 304
Cdd:cd15131 247 feagsleiaLISQYCNLVSFVLFYLSAAINPILYNIMSKKYRV 289
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
35-144 6.52e-04

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 40.60  E-value: 6.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15071   9 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEFYSCLMVACPVLILTQSSILA 88
                        90       100       110
                ....*....|....*....|....*....|
gi 47578039 115 aiLLAMAFDRCVAIREPLRYATILTTRRIG 144
Cdd:cd15071  89 --LLAIAVDRYLRVKIPTRYKSVVTPRRAA 116
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
30-172 7.59e-04

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 40.33  E-value: 7.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  30 AIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTF 109
Cdd:cd15210   4 AVWGIVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGL 83
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47578039 110 SVIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPL-PVLLGRLAFQP 172
Cdd:cd15210  84 VAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLwLGIWGRFGLDP 147
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
31-132 7.94e-04

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 40.50  E-value: 7.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  31 IPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAAC----FMQLFFI 106
Cdd:cd15384   5 VVLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCklvkYLQVFGL 84
                        90       100
                ....*....|....*....|....*.
gi 47578039 107 HtfsvIESAILLAMAFDRCVAIREPL 132
Cdd:cd15384  85 Y----LSTYITVLISLDRCVAILYPM 106
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
38-141 8.72e-04

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 40.23  E-value: 8.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  38 ILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIESAIL 117
Cdd:cd15318  12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHL 91
                        90       100
                ....*....|....*....|....
gi 47578039 118 LAMAFDRCVAIREPLRYATILTTR 141
Cdd:cd15318  92 CFISIDRHCAICDPLLYPSKFTIR 115
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
35-142 1.05e-03

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 40.19  E-value: 1.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15301   9 VLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNASV 88
                        90       100
                ....*....|....*....|....*...
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRR 142
Cdd:cd15301  89 LNLLIISFDRYFSVTRPLTYRARRTTKK 116
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
35-187 1.20e-03

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 40.13  E-value: 1.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15005   9 LILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIYGALSCKVIAFLAVLFCFHS 88
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47578039 115 AI-LLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPlPVL-LGRLAFQPVS---ALSHSYCVHPDVL 187
Cdd:cd15005  89 AFtLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFP-PVFdVGTYTFIREEdqcTFEHRSYKANDTL 165
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
27-163 1.59e-03

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 39.43  E-value: 1.59e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  27 CWTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRL-IGAAACFMQLFF 105
Cdd:cd15306   1 HWAALLILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMWpLPLVLCPIWLFL 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 47578039 106 IHTFSVIESAILLAMAFDRCVAIREPLRyATILTTRRIGAIGLAVV-VRSAALHLPLPV 163
Cdd:cd15306  81 DVLFSTASIMHLCAISLDRYIAIKKPIQ-ASQYNSRATAFIKITVVwLISIGIAIPVPI 138
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
35-239 1.68e-03

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 39.57  E-value: 1.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15095   9 IIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKFVNYMMQVTVQATC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGrlAFQPVSALSHSYCVHPdvlrlsCSST 194
Cdd:cd15095  89 LTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYR--LEEGYWYGPQTYCREV------WPSK 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 47578039 195 VVNSGFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERLKA 239
Cdd:cd15095 161 AFQKAYMIYTVLLTYVIPLAIIAVCYGLILRRLWRRSVDGNNQSE 205
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
35-181 1.69e-03

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 39.56  E-value: 1.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMqLFFIHTFSVIES 114
Cdd:cd15927   9 LIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKL-SEFLKDTSIGVS 87
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47578039 115 AILL-AMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYC 181
Cdd:cd15927  88 VFTLtALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFTLTDNQTIQIC 155
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
31-133 1.76e-03

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 39.28  E-value: 1.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  31 IPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAAC----FMQLFFI 106
Cdd:cd14986   5 AVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCrivkYLQVVGL 84
                        90       100
                ....*....|....*....|....*..
gi 47578039 107 HTfsviESAILLAMAFDRCVAIREPLR 133
Cdd:cd14986  85 FA----STYILVSMSLDRYQAIVKPMS 107
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
30-152 2.10e-03

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 39.23  E-value: 2.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  30 AIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTF 109
Cdd:cd15049   4 CIATGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYVA 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 47578039 110 SVIESAILLAMAFDRCVAIREPLRYATILTTRRIG-AIGLAVVV 152
Cdd:cd15049  84 SNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAIlMIALAWVI 127
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
34-304 2.23e-03

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 38.89  E-value: 2.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  34 CLIYILSVLGNIIIMHIV-KSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVI 112
Cdd:cd15104   7 AVLSPLIITGNLLVIVALlKLIRKKDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITSCAA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 113 ESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLpLPVLLGRLAFQPVSAL-SHSYCVHPDVLRLSC 191
Cdd:cd15104  87 SVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGF-LPLISPQFQQTSYKGKcSFFAAFHPRVLLVLS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 192 SSTVvnsgFGLFVMLSTLGMDAVLILLSYVLILKTVLSIASNAERL-------KAFNTCISHICAVLLFYTPLVSLSMIH 264
Cdd:cd15104 166 CMVF----FPALLLFVFCYCDILKIARVHSRAIYKVEHALARQIHPrrtlsdfKAARTVAVLIGCFLLSWLPFQITGLVQ 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 47578039 265 RFGRKKLPAQVymLLSYLHFL--MPPMLNPIVYSVKTKEIRV 304
Cdd:cd15104 242 ALCDECKLYDV--LEDYLWLLglCNSLLNPWIYAFWQKEVRR 281
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
21-161 2.23e-03

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 39.38  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039   21 GLETSHCWTAIPICLIYILSVLGNIIIMhIVKSVPSLHTPMYLFLSMLSMADLgLSASTLPSMVAVFLLGQRLIGAAACF 100
Cdd:PHA03087  35 GYDTNSTILIVVYSTIFFFGLVGNIIVI-YVLTKTKIKTPMDIYLLNLAVSDL-LFVMTLPFQIYYYILFQWSFGEFACK 112
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47578039  101 MQ--LFFIHTFSVIesAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPL 161
Cdd:PHA03087 113 IVsgLYYIGFYNSM--NFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPI 173
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
35-163 2.27e-03

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 39.03  E-value: 2.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15979   9 VIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVSVST 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPV 163
Cdd:cd15979  89 FSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPV 137
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
63-256 2.44e-03

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 39.01  E-value: 2.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  63 LFLSMLSMADLgLSASTLPSMVAVFLLGQRLI-GAAACFMQLFFIHTFSVIESAILLAMAFDRCVAIREPLRYATIlttR 141
Cdd:cd15366  37 VYLLNLSVSDL-LYIATLPLWIDYFLHRDNWIhGPESCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFAKV---R 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 142 RI-GAIGLAVVVRSAALHLPLPVLLGRLAFQpvSALSHSYCVHpdvlRLSCSSTVvnSGFGLFVMLSTLGMDAVLILLSY 220
Cdd:cd15366 113 RVkTAVAVSAVVWAIEIGANSAPLFHDELFR--DRYNHTFCFE----KYPMEDWV--AWMNLYRVFVGFLFPWVLMLFSY 184
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 47578039 221 VLILKTVLSIAS--NAERLKAFNTCISHICAVLLFYTP 256
Cdd:cd15366 185 RGILRAVRGNVSteQQEKAKIKRLALSLIAIVLLCFAP 222
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
34-166 2.86e-03

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 38.85  E-value: 2.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  34 CLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLlgQR---LIGAAACFMQLFFIHTFS 110
Cdd:cd15134   8 GIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIW--QQypwVFGEVFCKLRAFLSEMSS 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47578039 111 VIESAILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLG 166
Cdd:cd15134  86 YASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAIQTR 141
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
35-182 3.16e-03

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 38.76  E-value: 3.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLglsastlpsMVAVF---------LLGQRLIGAAACFMQLfF 105
Cdd:cd15207   9 LIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDL---------LVGVFcmpftlvdnILTGWPFGDVMCKLSP-L 78
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47578039 106 IHTFSVIESAI-LLAMAFDRCVAIREPLRYAtiLTTRRIGAIGLAVVVRSAALHLPLPVLLGRLAFQPVSALSHSYCV 182
Cdd:cd15207  79 VQGVSVAASVFtLVAIAVDRYRAVVHPTEPK--LTNRQAFVIIVAIWVLALAIMIPQALVLEVKEYQFFRGQTVHICV 154
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
30-131 3.30e-03

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 38.60  E-value: 3.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  30 AIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLP-SMVAVFLLGQRLIGAAACFMQLFFIHT 108
Cdd:cd15212   4 ALVLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPfAFLTLFSRPGWLFGDRLCLANGFFNAC 83
                        90       100
                ....*....|....*....|....
gi 47578039 109 FSVIESAILLAMAFDR-CVAIREP 131
Cdd:cd15212  84 FGIVSTLTMTLISFDRyYAIVRQP 107
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
31-143 4.04e-03

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 38.30  E-value: 4.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  31 IPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLP-SMVavfllgqRLIGAAACFMQLF-FIHT 108
Cdd:cd15055   5 IVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPfSMI-------RSIETCWYFGDTFcKLHS 77
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 47578039 109 F--SVIESAILLAM---AFDRCVAIREPLRYATILTTRRI 143
Cdd:cd15055  78 SldYILTSASIFNLvliAIDRYVAVCDPLLYPTKITIRRV 117
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
28-185 5.59e-03

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 37.68  E-value: 5.59e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  28 WTAIPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLP-SMVAVFLLGQRLIGAAACFMQLF-- 104
Cdd:cd15052   2 WAALLLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTld 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039 105 -FIHTFSVIEsaiLLAMAFDRCVAIREPLRYATiLTTRRIGAIGLAVV-VRSAALHLPLPVLlgrLAFQPVSALSHSYCV 182
Cdd:cd15052  82 vLFCTASIMH---LCTISLDRYMAIRYPLRTRR-NKSRTTVFLKIAIVwLISIGISSPIPVL---GIIDTTNVLNNGTCV 154

                ...
gi 47578039 183 HPD 185
Cdd:cd15052 155 LFN 157
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
35-134 6.12e-03

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 37.89  E-value: 6.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGN-IIIMHIVKSVPSLHTPMYLFLSMlSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIE 113
Cdd:cd15008   8 VLWLVSVFGNsLVCLVIHRSRRTQSTTNYFVVSM-ACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPGVQ 86
                        90       100
                ....*....|....*....|.
gi 47578039 114 SAILLAMAFDRCVAIREPLRY 134
Cdd:cd15008  87 IYVLLSICVDRFYTIVYPLSF 107
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
35-164 6.59e-03

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 37.57  E-value: 6.59e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFIHTFSVIES 114
Cdd:cd15124   9 IIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQLTSVGVSV 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47578039 115 AILLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVL 164
Cdd:cd15124  89 FTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEAVF 138
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
38-133 7.14e-03

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 37.49  E-value: 7.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  38 ILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAACFMQLFFiHTFSVIESAI- 116
Cdd:cd15391  12 FLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYV-QLVSVTASVLt 90
                        90
                ....*....|....*..
gi 47578039 117 LLAMAFDRCVAIREPLR 133
Cdd:cd15391  91 NTAIGIDRFFAVIFPLR 107
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
35-142 8.15e-03

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 37.36  E-value: 8.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADL-GLSASTLPSMVAVFL-LGQRLIGAAACFMQLFFIHTFSVI 112
Cdd:cd14995   9 LICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLmVLVAAGLPNEIESLLgPDSWIYGYAGCLLITYLQYLGINA 88
                        90       100       110
                ....*....|....*....|....*....|
gi 47578039 113 ESAILLAMAFDRCVAIREPLRYATILTTRR 142
Cdd:cd14995  89 SSLSITAFTIERYIAICHPMKAQFICTVSR 118
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
35-166 8.45e-03

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 37.24  E-value: 8.45e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  35 LIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADlGLSASTLPSMVAVFLLGQRLIGAAAC--FMQLFFIHTFSVI 112
Cdd:cd15091   9 VVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALAD-ALVTTTMPFQSTVYLMNSWPFGDVLCkiVISIDYYNMFTSI 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 47578039 113 ESaiLLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSAALHLPLPVLLG 166
Cdd:cd15091  88 FT--LTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGG 139
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
31-155 9.51e-03

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 37.15  E-value: 9.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47578039  31 IPICLIYILSVLGNIIIMHIVKSVPSLHTPMYLFLSMLSMADLGLSASTLPSMVAVFLLGQRLIGAAAC--FMQLFFIHT 108
Cdd:cd15957   5 IVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCefWTSIDVLCV 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 47578039 109 FSVIESaiLLAMAFDRCVAIREPLRYATILTTRRIGAIGLAVVVRSA 155
Cdd:cd15957  85 TASIET--LCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSG 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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