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Conserved domains on  [gi|4504545|ref|NP_000862|]
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5-hydroxytryptamine receptor 6 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11606721)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
27-331 3.57e-144

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


:

Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 411.89  E-value: 3.57e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   27 GWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFD 106
Cdd:cd15054   1 GWVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  107 VMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHAR-------PPVPGQ 179
Cdd:cd15054  81 VMCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIELGWHELGHERtlpnltsGTVEGQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  180 CRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAArkqavqvaslttgmasqasetlqvprtprpgvesadsrrlatkh 259
Cdd:cd15054 161 CRLLVSLPYALVASCLTFFLPSGAICFTYCRILLAA-------------------------------------------- 196
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4504545  260 sRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15054 197 -RKALKASLTLGILLGMFFVTWLPFFVANVVQAVCDCVSPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 267
 
Name Accession Description Interval E-value
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
27-331 3.57e-144

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 411.89  E-value: 3.57e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   27 GWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFD 106
Cdd:cd15054   1 GWVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  107 VMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHAR-------PPVPGQ 179
Cdd:cd15054  81 VMCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIELGWHELGHERtlpnltsGTVEGQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  180 CRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAArkqavqvaslttgmasqasetlqvprtprpgvesadsrrlatkh 259
Cdd:cd15054 161 CRLLVSLPYALVASCLTFFLPSGAICFTYCRILLAA-------------------------------------------- 196
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4504545  260 sRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15054 197 -RKALKASLTLGILLGMFFVTWLPFFVANVVQAVCDCVSPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 267
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
44-320 3.38e-67

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 214.85  E-value: 3.38e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545     44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALY-GRWVLARGLCLLWTAFDVMCCSASILNLCLISL 122
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545    123 DRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHElgHARPPVPGQCRLLASLP------FVLVASGLT 196
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTL--TVPEGNVTVCFIDFPEDlskpvsYTLLISVLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545    197 FFLPSGAICFTYCRILLAARKQAVQVASLTTgmasqasetlqvprtprpgvesadsrrlaTKHSRKALKaslTLGILLGM 276
Cdd:pfam00001 160 FLLPLLVILVCYTLIIRTLRKSASKQKSSER-----------------------------TQRRRKALK---TLAVVVVV 207
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 4504545    277 FFVTWLPFFVANIVQAVC-DCIS----PGLFDVLTWLGYCNSTMNPIIY 320
Cdd:pfam00001 208 FILCWLPYHIVNLLDSLAlDCELsrllDKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
26-164 3.30e-04

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 42.46  E-value: 3.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545    26 SGWVAAALCVVIALTAAANsLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYGRWVLARGLCLLWTAF 105
Cdd:PHA03087  40 STILIVVYSTIFFFGLVGN-IIVIYVLTKTKIKTPMDIYLLNLAVSDLLF-VMTLPFQIYYYILFQWSFGEFACKIVSGL 117
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545   106 DVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFlPLLL 164
Cdd:PHA03087 118 YYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETT-PILF 175
 
Name Accession Description Interval E-value
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
27-331 3.57e-144

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 411.89  E-value: 3.57e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   27 GWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFD 106
Cdd:cd15054   1 GWVAAFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  107 VMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHAR-------PPVPGQ 179
Cdd:cd15054  81 VMCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIELGWHELGHERtlpnltsGTVEGQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  180 CRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAArkqavqvaslttgmasqasetlqvprtprpgvesadsrrlatkh 259
Cdd:cd15054 161 CRLLVSLPYALVASCLTFFLPSGAICFTYCRILLAA-------------------------------------------- 196
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4504545  260 sRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15054 197 -RKALKASLTLGILLGMFFVTWLPFFVANVVQAVCDCVSPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
28-331 2.15e-94

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 284.84  E-value: 2.15e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDV 107
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGhaRPPVPGQCRLLASLP 187
Cdd:cd14967  81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQ--PSVVDCECEFTPNKI 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 FVLVASGLTFFLPSGAICFTYCRILLAARKQavqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsrkaLKAS 267
Cdd:cd14967 159 YVLVSSVISFFIPLLIMIVLYARIFRVARRE---------------------------------------------LKAA 193
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  268 LTLGILLGMFFVTWLPFFVANIVQAVC--DCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd14967 194 KTLAIIVGAFLLCWLPFFIIYLVSAFCppDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
33-330 8.63e-86

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 264.21  E-value: 8.63e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSA 112
Cdd:cd15065   6 LSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  113 SILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPG-------QCRLLAS 185
Cdd:cd15065  86 SILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIHLGWHRLSQDEIKGLNhasnpkpSCALDLN 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 LPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQasetlqvPRTPRPGVESADSRRLATKHsrkalK 265
Cdd:cd15065 166 PTYAVVSSLISFYIPCLVMLLIYSRLYLYARKHVVNIKSQKLPSESG-------SKFQVPSLSSKHNNQGVSDH-----K 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  266 ASLTLGILLGMFFVTWLPFFVANIVQAVCD-CISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15065 234 AAVTLGIIMGVFLICWLPFFIINIIAAFCKtCIPPKCFKILTWLGYFNSCLNPIIYSIFNSEFRRA 299
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
29-330 1.35e-80

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 250.81  E-value: 1.35e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALR-NTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLArGLCLLWTAFDV 107
Cdd:cd15057   3 TGCILYLLVLLTLLGNALVIAAVLRFRHLRsKVTNYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFG-SFCDVWVSFDI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPV-----PGQCRL 182
Cdd:cd15057  82 MCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVQLGWHRADDTSEALalyadPCQCDS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  183 LASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTtgmasqasetlqvpRTPRPGVESADSRRLATKHSRK 262
Cdd:cd15057 162 SLNRTYAISSSLISFYIPVAIMIVTYTRIYRIARRQIRRIAALE--------------RAAQESTNPDSSLRSSLRRETK 227
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  263 ALKaslTLGILLGMFFVTWLPFFVANIVQAVCD-------CISPGLFDVLTWLGYCNSTMNPIIYPlFMRDFKRA 330
Cdd:cd15057 228 ALK---TLSIIMGVFVCCWLPFFILNCVLPFCDlrtaqfpCVPDTTFIVFVWLGWANSSLNPIIYA-FNADFRKA 298
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
32-331 1.04e-69

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 222.43  E-value: 1.04e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   32 ALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCS 111
Cdd:cd15055   6 VLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLDYILTS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  112 ASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARP-PVPGQCRLLASLPFVL 190
Cdd:cd15055  86 ASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYDNLNQPGLIRYnSCYGECVVVVNFIWGV 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  191 VASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETlqvprtprpgvesadsrRLATKHSRKALKaslTL 270
Cdd:cd15055 166 VDLVLTFILPCTVMIVLYMRIFVVARSQARAIRSHTAQVSLEGSSK-----------------KVSKKSERKAAK---TL 225
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  271 GILLGMFFVTWLPFFVANIVQAVCDcISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15055 226 GIVVGVFLLCWLPYYIVSLVDPYIS-TPSSVFDVLIWLGYFNSCLNPLIYALFYPWFRKAL 285
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
29-331 1.13e-69

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 222.21  E-value: 1.13e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15051   3 LGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLDVM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPV--PGQCRLLASL 186
Cdd:cd15051  83 LCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIHLGWNTPDGRVQNGdtPNQCRFELNP 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  187 PFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTtgmasqasetlqvprtprPGVESADSRRLATKHSRkalKA 266
Cdd:cd15051 163 PYVLLVAIGTFYLPLLIMCGVYLRIFRIAREQAKRINALT------------------PASTANSSKSAATAREH---KA 221
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  267 SLTLGILLGMFFVTWLPFFVANIVQAVCDC-ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15051 222 TVTLAAVLGAFIICWFPYFTYFTYRGLCGDnINETALSVVLWLGYANSALNPILYAFLNRDFRRAF 287
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
29-330 1.05e-68

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 219.15  E-value: 1.05e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGR-WVLARGLCLLWTAFDV 107
Cdd:cd15067   2 LGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGyWLFGRDWCDVWHSFDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFlPLLLGWHELGHARPPvPGQCRLLASLP 187
Cdd:cd15067  82 LASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISF-PAIAWWRAVDPGPSP-PNQCLFTDDSG 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 FVLVASGLTFFLPSGAICFTYCRILLAARKQavqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsRKALKas 267
Cdd:cd15067 160 YLIFSSCVSFYIPLVVMLFTYYRIYRAAAKE------------------------------------------QKAAK-- 195
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  268 lTLGILLGMFFVTWLPFFVANIVQAVC--DCISPG--LFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15067 196 -TLGIVMGVFILCWLPFFVTNILIGFCpsNCVSNPdiLFPLVTWLGYINSGMNPIIYACSSRDFRRA 261
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
29-331 9.10e-68

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 216.44  E-value: 9.10e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15059   3 ISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFlPLLLGWHELGHARPPVPgQCRLLASLPF 188
Cdd:cd15059  83 FCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISL-PPLFGWKDEQPWHGAEP-QCELSDDPGY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  189 VLVASGLTFFLPSGAICFTYCRILLAARKQavqvaslttgmasqasetlqvprtprpgvesadSRRLatkhsrkalkaSL 268
Cdd:cd15059 161 VLFSSIGSFYIPLLIMIIVYARIYRAAKRK---------------------------------ERRF-----------TL 196
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  269 TLGILLGMFFVTWLPFFVANIVQAVCD--CISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15059 197 VLGVVMGAFVLCWLPFFFTYPLVVVCKtcGVPELLFKFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
29-329 2.21e-67

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 215.60  E-value: 2.21e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15329   3 IGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLLGWHELGHarppVPGQCRLLASLPF 188
Cdd:cd15329  83 LCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALIS-IPPLFGWKNKVN----DPGVCQVSQDFGY 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  189 VLVASGLTFFLPSGAICFTYCRILLAARKQAvqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsrkalKASL 268
Cdd:cd15329 158 QIYATFGAFYIPLIVMLVLYYKIYRAAKSER---------------------------------------------KAIK 192
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  269 TLGILLGMFFVTWLPFFVANIVQAVC-----DCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15329 193 TLGIIMGAFTLCWLPFFILALLRPFLkpikcSCIPLWLSRLFLWLGYANSFLNPIIYAKFNREFRT 258
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
44-320 3.38e-67

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 214.85  E-value: 3.38e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545     44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALY-GRWVLARGLCLLWTAFDVMCCSASILNLCLISL 122
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545    123 DRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHElgHARPPVPGQCRLLASLP------FVLVASGLT 196
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTL--TVPEGNVTVCFIDFPEDlskpvsYTLLISVLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545    197 FFLPSGAICFTYCRILLAARKQAVQVASLTTgmasqasetlqvprtprpgvesadsrrlaTKHSRKALKaslTLGILLGM 276
Cdd:pfam00001 160 FLLPLLVILVCYTLIIRTLRKSASKQKSSER-----------------------------TQRRRKALK---TLAVVVVV 207
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 4504545    277 FFVTWLPFFVANIVQAVC-DCIS----PGLFDVLTWLGYCNSTMNPIIY 320
Cdd:pfam00001 208 FILCWLPYHIVNLLDSLAlDCELsrllDKALSVTLWLAYVNSCLNPIIY 256
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
28-330 2.49e-66

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 214.24  E-value: 2.49e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDV 107
Cdd:cd15058   2 GLLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPV----PGQCRLL 183
Cdd:cd15058  82 LCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFVPIMNQWWRANDPEANDcyqdPTCCDFR 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  184 ASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQaVQVASLTTGMASQASETLQVPRTPRpgvESADSRRLATKHSRKA 263
Cdd:cd15058 162 TNMAYAIASSVVSFYIPLLIMIFVYARVFLIATRQ-LQLIDKRRLRFQSECPAPQTTSPEG---KRSSGRRPSRLTVVKE 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504545  264 LKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG-LFDVLTWLGYCNSTMNPIIYPLFMrDFKRA 330
Cdd:cd15058 238 HKALKTLGIIMGTFTLCWLPFFIANIINVFNRNLPPGeVFLLLNWLGYINSGLNPIIYCRSP-EFRTA 304
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
29-330 8.77e-62

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 201.02  E-value: 8.77e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15064   3 ISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDVT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLLGWHelgHARPPVPGQCRLLASLPF 188
Cdd:cd15064  83 CCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICIS-LPPLFGWR---TPDSEDPSECLISQDIGY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  189 VLVASGLTFFLPSGAICFTYCRILLAARKQavqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsRKALKasl 268
Cdd:cd15064 159 TIFSTFGAFYIPLLLMLILYWKIYRAAARE------------------------------------------RKAAK--- 193
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504545  269 TLGILLGMFFVTWLPFFVANIVQAVCDC--ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15064 194 TLGIILGAFIVCWLPFFLVALIVPLCSHcwIPLALKSFFLWLGYFNSLINPLIYTFFNKDFRKA 257
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
33-330 2.50e-61

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 201.18  E-value: 2.50e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSA 112
Cdd:cd15056   7 LSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDVLLTTA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  113 SILNLCLISLDRYLLI-LSPLRYKlrMTPLRALALVLGAWSLAALASFLPLLLGWHELG------HARPPVPGQCRLLAS 185
Cdd:cd15056  87 SIMHLCCIALDRYYAIcCQPLVYK--MTPLRVAVMLGGCWVIPTFISFLPIMQGWNHIGiedliaFNCASGSTSCVFMVN 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 LPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTtgmasqasetlqvprtpRPGVESADSRRLATKHSRKALK 265
Cdd:cd15056 165 KPFAIICSTVAFYIPALLMVLAYYRIYVAAREQAHQIRSLQ-----------------RAGSSNHEADQHRNSRMRTETK 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  266 ASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGL-FDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15056 228 AAKTLGIIMGCFCVCWAPFFVTNIVDPFIGYRVPYLlWTAFLWLGYINSGLNPFLYAFFNKSFRRA 293
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
30-320 3.43e-61

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 200.21  E-value: 3.43e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   30 AAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMC 109
Cdd:cd00637   2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  110 CSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLL-LGWHELGHARPPVPGQCRLLASLPF 188
Cdd:cd00637  82 LLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLgWGVYDYGGYCCCCLCWPDLTLSKAY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  189 VLVASGLTFFLPSGAICFTYCRILLAARKQavqvaslttgmasqasetlqvpRTPRPGVESADSRRLATKHSRKALKasl 268
Cdd:cd00637 162 TIFLFVLLFLLPLLVIIVCYVRIFRKLRRH----------------------RRRIRSSSSNSSRRRRRRRERKVTK--- 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  269 TLGILLGMFFVTWLPFFVANIVQAVCD---CISPGLFDVLTWLGYCNSTMNPIIY 320
Cdd:cd00637 217 TLLIVVVVFLLCWLPYFILLLLDVFGPdpsPLPRILYFLALLLAYLNSAINPIIY 271
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
33-331 2.22e-60

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 199.46  E-value: 2.22e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIALICTQPALRN-TSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLArGLCLLWTAFDVMCCS 111
Cdd:cd15320   8 LSVLILSTLLGNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCST 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  112 ASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWH--------ELGHARPPVP-GQCRL 182
Cdd:cd15320  87 ASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFIPVQLNWHkakptsflDLNASLRDLTmDNCDS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  183 LASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLT-TGMASQASETLQVPRTPRPGVESADSRRLATKHSR 261
Cdd:cd15320 167 SLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALErAAVHAKNCQNSTGNRGSGDCQQPESSFKMSFKRET 246
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  262 KALKaslTLGILLGMFFVTWLPFFVANIVQAVCD-------CISPGLFDVLTWLGYCNSTMNPIIYPlFMRDFKRAL 331
Cdd:cd15320 247 KVLK---TLSVIMGVFVCCWLPFFILNCMVPFCKptstepfCISSTTFDVFVWFGWANSSLNPIIYA-FNADFRKAF 319
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
29-327 2.68e-59

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 195.90  E-value: 2.68e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15959   3 AGALLSLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPV-----PGQCRLL 183
Cdd:cd15959  83 CVTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIMNQWWRDGADEEAQrcydnPRCCDFV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  184 ASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQavqvASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHsRKA 263
Cdd:cd15959 163 TNMPYAIVSSTVSFYVPLLVMIFVYVRVFVVATRQ----VRLIRKDKVRFPPEESPPAESRPACGRRPSRLLAIKE-HKA 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504545  264 LKaslTLGILLGMFFVTWLPFFVANIVQAVCDCISPG-LFDVLTWLGYCNSTMNPIIY---PLFMRDF 327
Cdd:cd15959 238 LK---TLGIIMGTFTLCWLPFFVANIIKVFCRSLVPDpAFLFLNWLGYANSAFNPIIYcrsPDFRSAF 302
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
30-330 1.11e-58

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 192.95  E-value: 1.11e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   30 AAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAM-LNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15053   4 ALFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVyVEVNGGKWYLGPILCDIYIAMDVM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLLGwheLGHARPPVPGQCRLLASlPF 188
Cdd:cd15053  84 CSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIA-CPLLFG---LNNVPYRDPEECRFYNP-DF 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  189 VLVASGLTFFLPSGAICFTYCRILLAARKQavqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsRKALKasl 268
Cdd:cd15053 159 IIYSSISSFYIPCIVMLLLYYRIFRALRRE------------------------------------------KKATK--- 193
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  269 TLGILLGMFFVTWLPFFVANIVQAVCD-------CISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15053 194 TLAIVLGVFLFCWLPFFTLNILNAICPklqnqscHVGPALFSLTTWLGYVNSFLNPIIYTIFNIEFRKA 262
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
32-330 1.44e-58

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 192.98  E-value: 1.44e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   32 ALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCS 111
Cdd:cd15066   5 AMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFST 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  112 ASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWH---ELGHARPPVPGQCRLLASLPF 188
Cdd:cd15066  85 ASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLPIFLGWYtteEHLQYRKTHPDQCEFVVNKIY 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  189 VLVASGLTFFLPSGAICFTYCRILLAARKQAvqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsrkalKASL 268
Cdd:cd15066 165 ALISSSVSFWIPCIVMIFTYYRIYLEAKREH---------------------------------------------KAAK 199
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  269 TLGILLGMFFVTWLPFFVANIVQAVC--DCISPG-LFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15066 200 TLGIIMGAFILCWLPFFLWYVTTTLCgdACPYPPiLVSILFWIGYFNSTLNPLIYAYFNRDFREA 264
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
29-330 2.70e-58

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 193.29  E-value: 2.70e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15048   3 LAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDYT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALAsFLPLLLGWHELGHARPPVPGQC--RLLASL 186
Cdd:cd15048  83 LCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLL-YGPAIIGWDLWTGYSIVPTGDCevEFFDHF 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  187 PFVLVASGLTFFLPSGAICFTYCRILLAARKQavqvaslttgmaSQASETLQVPRTPRPGVESADSRRLATKHSRKALKA 266
Cdd:cd15048 162 YFTFITSVLEFFIPFISVSFFNLLIYLNIRKR------------SRRRPLRSVPILPASQNPSRARSQREQVKLRRDRKA 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  267 SLTLGILLGMFFVTWLPFFVANIVQAVCD--CISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15048 230 AKSLAILVLVFLICWAPYTILTIIRSFCSgsCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRKA 295
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
33-331 6.89e-58

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 191.69  E-value: 6.89e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSA 112
Cdd:cd15314   7 LGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSFDITLCTA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  113 SILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVP--GQCRLLASLPFVL 190
Cdd:cd15314  87 SILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLELNIKGIYYNHVAceGGCLVFFSKVSSV 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  191 VASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGmasqasetlqvprtprpgvesadSRRLATKHSRKALKaslTL 270
Cdd:cd15314 167 VGSVFSFYIPAVIMLCIYLKIFLVAQRQARSIQSARTK-----------------------SGASSSKMERKATK---TL 220
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4504545  271 GILLGMFFVTWLPFFVANIVQAVCDC-ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15314 221 AIVMGVFLLCWTPFFLCNIIDPFINYsIPPVLIEVLNWLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
29-330 2.21e-57

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 189.49  E-value: 2.21e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15061   2 LISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWsLAALASFLPLLLGWHElgHARPPVpGQCRLLASLPF 188
Cdd:cd15061  82 LCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVW-VISLLITSPPLVGPSW--HGRRGL-GSCYYTYDKGY 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  189 VLVASGLTFFLPSGAICFTYCRILLAARKQavqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsRKALKasl 268
Cdd:cd15061 158 RIYSSMGSFFLPLLLMLFVYLRIFRVIAKE------------------------------------------RKTAK--- 192
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504545  269 TLGILLGMFFVTWLPFFVANIVQAVCDC-ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15061 193 TLAIVVGCFIVCWLPFFIMYLIEPFCDCqFSEALSTAFTWLGYFNSVINPFIYAFYNKDFRRA 255
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
33-330 6.86e-57

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 188.41  E-value: 6.86e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSA 112
Cdd:cd15060   7 LSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCCTA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  113 SILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLLGWHEL-GHARPPVPgqCRLLASLPFVLV 191
Cdd:cd15060  87 SILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALIS-VPPLIGWNDWpENFTETTP--CTLTEEKGYVIY 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  192 ASGLTFFLPSGAICFTYCRILLAARKQAvqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsrkalKASLTLG 271
Cdd:cd15060 164 SSSGSFFIPLLIMTIVYVKIFIATSKER---------------------------------------------RAARTLG 198
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  272 ILLGMFFVTWLPFFVANIVQAVCD--CISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15060 199 IIMGVFVVCWLPFFLMYVILPFCEtcSPSAKVVNFITWLGYVNSALNPVIYTIFNLDFRRA 259
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
31-330 2.98e-54

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 181.54  E-value: 2.98e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCC 110
Cdd:cd15063   5 LVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  111 SASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFlPLLLGWHELGHARPP------VPGQCRLLA 184
Cdd:cd15063  85 TASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICF-PPLVGWNDGKDGIMDysgsssLPCTCELTN 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  185 SLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAvqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsrkal 264
Cdd:cd15063 164 GRGYVIYSALGSFYIPMLVMLFFYFRIYRAARMET--------------------------------------------- 198
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  265 KASLTLGILLGMFFVTWLPFFVANIVQAVC-DCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15063 199 KAAKTVAIIVGCFIFCWLPFFTVYLVRAFCeDCIPPLLFSVFFWLGYCNSALNPCIYALFSRDFRFA 265
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
30-331 7.67e-54

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 182.46  E-value: 7.67e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   30 AAALCVVIALTAAANSLLIALICTQPALR-NTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLArGLCLLWTAFDVM 108
Cdd:cd15319   4 GCLLSLLILWTLLGNILVCAAVVRFRHLRsKVTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHE------LGHARPPVP----G 178
Cdd:cd15319  83 CSTASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPVQLNWHKdsgddwVGLHNSSISrqveE 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  179 QCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLttgmaSQASETLQVPRTPRPGVESADSRRLATK 258
Cdd:cd15319 163 NCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQIQIRRISSL-----ERAAEHAQSCRSNRIDCHHHTSLRTSIK 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  259 HSRKALKaslTLGILLGMFFVTWLPFFVANIVQAVCD-----------CISPGLFDVLTWLGYCNSTMNPIIYPlFMRDF 327
Cdd:cd15319 238 KETKVLK---TLSVIMGVFVCCWLPFFILNCMVPFCDrppadpdaglpCVSETTFDVFVWFGWANSSLNPIIYA-FNADF 313

                ....
gi 4504545  328 KRAL 331
Cdd:cd15319 314 RKVF 317
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
27-330 1.42e-53

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 179.82  E-value: 1.42e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   27 GWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYG-RWVLARGLCLLWTAF 105
Cdd:cd15052   1 NWAALLLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGgVWPLPLVLCLLWVTL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  106 DVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHElgHARPPVPGQCrLLAS 185
Cdd:cd15052  81 DVLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGIID--TTNVLNNGTC-VLFN 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 LPFVLVASGLTFFLPSGAICFTYCrillaarkqavqvasLTTgmasqasetlqvprtprpgvesadsRRLATKHsrkalK 265
Cdd:cd15052 158 PNFVIYGSIVAFFIPLLIMVVTYA---------------LTI-------------------------RLLSNEQ-----K 192
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  266 ASLTLGILLGMFFVTWLPFFVANIVQAVCDC----ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15052 193 ASKVLGIVFAVFVICWCPFFITNILTGLCEEcncrISPWLLSVFVWLGYVSSTINPIIYTIFNKTFRRA 261
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
33-327 4.90e-53

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 179.71  E-value: 4.90e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSA 112
Cdd:cd15958   7 MALIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCVTA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  113 SILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGW--HELGHARPPV--PGQCRLLASLPF 188
Cdd:cd15958  87 SIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSFLPIMMHWwrDEDDQALKCYedPGCCDFVTNRAY 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  189 VLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTtgmasqaSETLQVPRTPRPGVESADSRRLATKHsRKALKasl 268
Cdd:cd15958 167 AIASSIISFYIPLLIMIFVYLRVYREAKKQIKKIDKCE-------GRFHNTLTGLGRKCKRRPSRILALRE-QKALK--- 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504545  269 TLGILLGMFFVTWLPFFVANIVQAVC-DCISPGLFDVLTWLGYCNSTMNPIIY---PLFMRDF 327
Cdd:cd15958 236 TLGIIMGVFTLCWLPFFLVNVVNVFNrELVPDWLFVFFNWLGYANSAFNPIIYcrsPDFRKAF 298
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
29-331 6.15e-49

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 167.50  E-value: 6.15e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15049   3 ICIATGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALAsFLPLLLGWHELGHARPPVPGQC--RLLASL 186
Cdd:cd15049  83 ASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVL-WAPAILGWQYFVGERTVPDGQCyiQFLDDP 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  187 PFVLVASGLTFFLPSGAICFTYCRILLAARKQavqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsRKALKa 266
Cdd:cd15049 162 AITFGTAIAAFYLPVLVMTILYWRIYRETARE------------------------------------------RKAAR- 198
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  267 slTLGILLGMFFVTWLPFFVANIVQAVCD-CISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15049 199 --TLSAILLAFIITWTPYNILVLVSTFCAkCIPDTLWSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
32-330 1.05e-48

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 167.22  E-value: 1.05e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   32 ALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCS 111
Cdd:cd15050   6 ALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVAST 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  112 ASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALasFLPLLLGWHELGHARPPV--PGQC--RLLASLP 187
Cdd:cd15050  86 ASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFL--WVIPILGWHHFARGGERVvlEDKCetDFHDVTW 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 FVLVASGLTFFLPSGAICFTYCRILLAARKQavqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsRKALKas 267
Cdd:cd15050 164 FKVLTAILNFYIPSLLMLWFYAKIFKAVNRE------------------------------------------RKAAK-- 199
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504545  268 lTLGILLGMFFVTWLPFFVANIVQAVC-DCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15050 200 -QLGFIMAAFILCWIPYFILFMVIAFCkNCCNENLHMFTIWLGYINSTLNPFIYPLCNENFKKT 262
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
37-331 4.12e-48

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 166.38  E-value: 4.12e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   37 IALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILN 116
Cdd:cd15312  11 ILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFH 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  117 LCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELG----HARPPVPGQCRLLASLPFVLVA 192
Cdd:cd15312  91 LCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFGVVFSEVNLEGiedyVALVSCTGSCVLIFNKLWGVIA 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  193 SGLTFFLPSGAICFTYCRILLAARKQAVQVASlttgmasqasetlqvprtpRPGVESADSRR-LATKHSRKALKaslTLG 271
Cdd:cd15312 171 SLIAFFIPGTVMIGIYIKIFFVARKHAKVINN-------------------RPSVTKGDSKNkLSKKKERKAAK---TLS 228
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  272 ILLGMFFVTWLPFFVANIVQAVCDCISP-GLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15312 229 IVMGVFLLCWLPFFVATLIDPFLNFSTPvDLFDALVWLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
29-331 6.26e-48

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 165.07  E-value: 6.26e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15326   3 LGLVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWHElghARPPVPGQCRLLASLPF 188
Cdd:cd15326  83 CCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGP-LLGWKE---PAPPDDKVCEITEEPFY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  189 VLVASGLTFFLPSGAICFTYCRILLaarkqavqvaslttgmasqasetlqvprtprpgvesadsrrLATKHSRKAlKASL 268
Cdd:cd15326 159 ALFSSLGSFYIPLIVILVMYCRVYI-----------------------------------------VALKFSREK-KAAK 196
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  269 TLGILLGMFFVTWLPFFVANIVQAVCDCISP--GLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15326 197 TLGIVVGMFILCWLPFFIALPLGSLFSHLKPpeTLFKIIFWLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
25-320 7.97e-47

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 163.50  E-value: 7.97e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   25 GSGWVAAALCVVIALtaaANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTA 104
Cdd:cd15957   2 GMGIVMSLIVLAIVF---GNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  105 FDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARP----PVPGQC 180
Cdd:cd15957  79 IDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAincyAEETCC 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  181 RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQasetlqvpRTPRPGVESADSRRLATKHS 260
Cdd:cd15957 159 DFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHNQ--------NIDQNGSGGGGGNRRRSKFC 230
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  261 RKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG-LFDVLTWLGYCNSTMNPIIY 320
Cdd:cd15957 231 LKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKeVYILLNWIGYVNSGFNPLIY 291
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
28-331 1.71e-46

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 162.23  E-value: 1.71e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALtaAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDV 107
Cdd:cd15317   4 YIVLVLAMLITV--SGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGH----ARPPVPGQCRLL 183
Cdd:cd15317  82 LLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYTGANDEGLeeysSEISCVGGCQLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  184 ASLPFVLVASgLTFFLPSGAICFTYCRILLAARKQAVQVAslTTGMASQASETlqvprtprpgvesaDSRRLATKHSRKA 263
Cdd:cd15317 162 FNKIWVLLDF-LTFFIPCLIMIGLYAKIFLVARRQARKIQ--NMEDKFRSSEE--------------NSSKASASRERKA 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  264 LKaslTLGILLGMFFVTWLPFFVANIVQAVCDCISPGL-FDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15317 225 AK---TLAIVMGIFLFCWLPYFIDTIVDEYSNFITPAIvFDAVIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
29-330 5.12e-46

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 159.83  E-value: 5.12e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15331   3 TSIILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCDMWISMDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLIlSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLLGW-HELGHARPPVPGQCRLLASLP 187
Cdd:cd15331  83 CCTASILHLVAIALDRYWAV-TNIDYIRRRTAKRILIMIAVVWFVSLIIS-IAPLFGWkDEDDLDRVLKTGVCLISQDYG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 FVLVASGLTFFLPSGAICFTYCRILLAArkqavqvaslttgmasqasetlqvprtprpgvesadsrrlatKHSRKALKas 267
Cdd:cd15331 161 YTIFSTVGAFYVPLLLMIIIYWKIYQAA------------------------------------------KRERKAAR-- 196
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  268 lTLGILLGMFFVTWLPFFVANIVQAVCDC--ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15331 197 -TLAIITGAFVVCWLPFFLVALVMPFCGAwqISRFLESFFLWLGYFNSLLNPIIYTIFSPDFRGA 260
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
29-330 2.25e-45

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 158.42  E-value: 2.25e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15062   3 VGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWHElghARPPVPGQCRLLASLPF 188
Cdd:cd15062  83 CCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGP-LLGWKE---PAPADEQACGVNEEPGY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  189 VLVASGLTFFLPSGAICFTYCRILlaarkqavqvaslttgmasqasetlqvprtprpgvesadsrRLATKHSRKAlKASL 268
Cdd:cd15062 159 VLFSSLGSFYLPLAIILVMYCRVY-----------------------------------------VVAFKFSREK-KAAK 196
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504545  269 TLGILLGMFFVTWLPFFVANIVQAVCDCISP--GLFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15062 197 TLGIVVGAFVLCWFPFFVVLPLGSLFSTLKPpePVFKVVFWLGYFNSCLNPIIYPCSSREFKRA 260
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
28-337 4.65e-45

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 157.76  E-value: 4.65e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYG-RWVLARGLCLLWTAFD 106
Cdd:cd15305   2 WPALLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDyAWPLPRYLCPIWISLD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  107 VMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHElgHARPPVPGQCRLLASL 186
Cdd:cd15305  82 VLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMPIPVIGLQD--DEKVFVNGTCVLNDEN 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  187 pFVLVASGLTFFLPSGAICFTYCRILLAARKQAvqvaslttgmasqasetlqvprtprpgvesadsrrlATKHSRKALKa 266
Cdd:cd15305 160 -FVLIGSFVAFFIPLIIMVITYCLTIQVLQRQQ------------------------------------AINNERRASK- 201
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  267 slTLGILLGMFFVTWLPFFVANIVQAVCD--C---ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPC 337
Cdd:cd15305 202 --VLGIVFFLFLIMWCPFFITNILSVLCKeaCdqkLMEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAFSNYIRC 275
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
22-331 1.17e-44

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 156.62  E-value: 1.17e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   22 APGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLL 101
Cdd:cd15321   2 SVQATAAIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  102 WTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELG--HARPpvpgQ 179
Cdd:cd15321  82 YLALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDeqGGLP----Q 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  180 CRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKqavqvaslttgmasqasetlqvprtprpgvesadsrrlatkh 259
Cdd:cd15321 158 CKLNEEAWYILSSSIGSFFAPCLIMILVYLRIYLIAKN------------------------------------------ 195
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  260 srKALKASLTLGILLGMFFVTWLPFFVANIVQAVCD--CISP-GLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15321 196 --REKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPelCKVPhSLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
29-331 3.33e-44

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 155.09  E-value: 3.33e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15323   3 LAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPvpgQCRLLASLPF 188
Cdd:cd15323  83 FCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDPEGDVYP---QCKLNDETWY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  189 VLVASGLTFFLPSGAICFTYCRILLAARkqavqvaslttgmasqasetlqvprtprpgvesADSRRLatkhsrkalkaSL 268
Cdd:cd15323 160 ILSSCIGSFFAPCLIMILVYIRIYRVAK---------------------------------AREKRF-----------TF 195
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  269 TLGILLGMFFVTWLPFFVANIVQAVCD--CISP-GLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15323 196 VLAVVMGVFVVCWFPFFFSYSLYGICReaCEVPePLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
35-331 7.42e-44

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 154.33  E-value: 7.42e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15322   9 LLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVpgqCRLLASLPFVLVASG 194
Cdd:cd15322  89 VHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQPEGPI---CKINDEKWYIISSCI 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  195 LTFFLPSGAICFTYCRILLAARKqavqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsrKALKASLTLGILL 274
Cdd:cd15322 166 GSFFAPCLIMVLVYIRIYQIAKN--------------------------------------------REKRFTFVLAVVI 201
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4504545  275 GMFFVTWLPFFVANIVQAVCDCISPG-LFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15322 202 GVFVICWFPFFFTYTLTAVCDCSVPEtLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
28-331 8.72e-44

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 154.32  E-value: 8.72e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYG-RWVLARGLCLLWTAFD 106
Cdd:cd15304   2 WPALLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGyRWPLPSKLCAVWIYLD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  107 VMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHElgHARPPVPGQCrLLASL 186
Cdd:cd15304  82 VLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQD--DSKVFKEGSC-LLADE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  187 PFVLVASGLTFFLPSGAICFTYcrillaarkqavqvaSLTTGMASQASETLQvprtprpgvesadsrrlatkhsrkalKA 266
Cdd:cd15304 159 NFVLIGSFVAFFIPLTIMVITY---------------FLTIKSLQQSISNEQ--------------------------KA 197
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  267 SLTLGILLGMFFVTWLPFFVANIVQAVCD--C---ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15304 198 SKVLGIVFFLFVVMWCPFFITNVMAVICKesCnevVIGGLLNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
28-337 1.08e-43

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 154.34  E-value: 1.08e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIaLTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDV 107
Cdd:cd15307   3 WALLALVLVL-GTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLaALASFLPLLLGWHElGHARPPVPGQCRLLASLp 187
Cdd:cd15307  82 LFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLL-SIAMSLPLSLMYSK-DHASVLVNGTCQIPDPV- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 FVLVASGLTFFLPSGAICFTYCrilLAARKQAVQvaslttgmasqasetlqvprtprpgvesadsRRLATKHSRKALKAS 267
Cdd:cd15307 159 YKLVGSIVCFYIPLGVMLLTYC---LTVRLLARQ-------------------------------RSRHGRIIRLEQKAT 204
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504545  268 LTLGILLGMFFVTWLPFFVANIVQAVCDC----ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPC 337
Cdd:cd15307 205 KVLGVVFFTFVILWSPFFVLNLLPTVCAEceerISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLC 278
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
33-331 2.46e-43

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 152.80  E-value: 2.46e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYG-RWVLARGLCLLWTAFDVMCCS 111
Cdd:cd15328   7 LAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGrRWQLGRSLCQVWISFDVLCCT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  112 ASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWhelGHARPPVPGQCRLLASLPFVLV 191
Cdd:cd15328  87 ASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLLFGW---GETYSEDSEECQVSQEPSYTVF 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  192 ASGLTFFLPSGAICFTYCRILLAARKQAvqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsrkalKASLTLG 271
Cdd:cd15328 164 STFGAFYLPLCVVLFVYWKIYKAAQKEK---------------------------------------------RAALMVG 198
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  272 ILLGMFFVTWLPFFVANIVQAVCDCISPGLF-DVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15328 199 ILIGVFVLCWIPFFLTELISPLCSCDIPPIWkSIFLWLGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
29-331 5.03e-43

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 152.00  E-value: 5.03e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15335   3 IVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDMT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLlgWHElgHARPPVPGQCRLLAS-LP 187
Cdd:cd15335  83 CCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLF--WRN--HHDANIPSQCIIQHDhVI 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 FVLVASGLTFFLPSGAICFTYCRILLAARKQAvqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsrkalKAS 267
Cdd:cd15335 159 YTIYSTFGAFYIPLTLILILYYRIYHAASRER---------------------------------------------KAA 193
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  268 LTLGILLGMFFVTWLPFFVANIVQAVCDC-ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15335 194 RILGLILGAFILSWLPFFIKELIVGLSVMtVSPEVADFLTWLGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
33-331 1.06e-42

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 151.28  E-value: 1.06e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSA 112
Cdd:cd15330   7 LGTLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  113 SILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLLGWhelghaRPPV----PGQCRLLASLPF 188
Cdd:cd15330  87 SILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSIS-IPPMLGW------RTPEdrsdPDACTISKDPGY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  189 VLVASGLTFFLPSGAICFTYCRILLAARKQavqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsRKALKasl 268
Cdd:cd15330 160 TIYSTFGAFYIPLILMLVLYGRIFKAAARE------------------------------------------RKTVK--- 194
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  269 TLGILLGMFFVTWLPFFVANIVQAVCD--CISPG-LFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15330 195 TLGIIMGTFILCWLPFFIVALVLPFCEstCHMPElLGAIINWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
32-331 1.58e-42

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 150.41  E-value: 1.58e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   32 ALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCS 111
Cdd:cd15324   6 VVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  112 ASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHElgharppvPGQCRLLASLPFVLV 191
Cdd:cd15324  86 SSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMTKHD--------EWECLLNDETWYILS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  192 ASGLTFFLPSGAICFTYCRILLAARKQavqvaslttgmasqasetlqvprtprpgvesadSRRLatkhsrkalkaSLTLG 271
Cdd:cd15324 158 SCTVSFFAPGLIMILVYCKIYRVAKMR---------------------------------EKRF-----------TFVLA 193
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504545  272 ILLGMFFVTWLPFFVANIVQAVC--DCISPG-LFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15324 194 VVMGVFVLCWFPFFFTYSLHAVCrkRCGIPDaLFNLFFWIGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
29-331 2.23e-42

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 150.45  E-value: 2.23e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15327   3 VGVFLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWHElghARPPVPGQCRLLASLPF 188
Cdd:cd15327  83 CCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGP-LLGWKE---PPPPDESICSITEEPGY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  189 VLVASGLTFFLPSGAICFTYCRILLaarkqavqvaslttgmasqasetlqvprtprpgvesadsrrLATKHSRKAlKASL 268
Cdd:cd15327 159 ALFSSLFSFYLPLMVILVMYFRVYV-----------------------------------------VALKFSREK-KAAK 196
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  269 TLGILLGMFFVTWLPFFVANIVQAVCDCISP--GLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15327 197 TLAIVVGVFILCWFPFFFVLPLGSFFPALKPseMVFKVIFWLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
29-331 5.23e-42

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 149.33  E-value: 5.23e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15334   3 ISLTLSILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDIT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLlgWHELGHARppvPGQCRLLAS-LP 187
Cdd:cd15334  83 CCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLF--WRHQTTSR---EDECIIKHDhIV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 FVLVASGLTFFLPSGAICFTYCRILLAARKQAvqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsrkalKAS 267
Cdd:cd15334 158 FTIYSTFGAFYIPLALILILYYKIYRAATRER---------------------------------------------KAA 192
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  268 LTLGILLGMFFVTWLPFFVANIVQAVCD-C-ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15334 193 TTLGLILGAFVICWLPFFVKEVIVNTCDsCyISEEMSNFLTWLGYINSLINPLIYTIFNEDFKKAF 258
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
28-331 2.55e-41

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 147.42  E-value: 2.55e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAM-LNALYGRWVLARGLCLLWTAFD 106
Cdd:cd15310   2 YYALSYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVyLEVTGGVWNFSRICCDVFVTLD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  107 VMCCSASILNLCLISLDRYLLILSPLRYKLRMT--PLRALALVLGAWSLAALASFLPLLLGWHELGHarppvPGQCRlLA 184
Cdd:cd15310  82 VMMCTASILNLCAISIDRYTAVVMPVHYQHGTGqsSCRRVSLMITAVWVLAFAVSCPLLFGFNTTGD-----PTVCS-IS 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  185 SLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAvqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsrkal 264
Cdd:cd15310 156 NPDFVIYSSVVSFYLPFGVTLLVYVRIYVVLLREK--------------------------------------------- 190
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  265 KASLTLGILLGMFFVTWLPFFVANIVQAVCDC--ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15310 191 KATQMLAIVLGAFIVCWLPFFLTHILNTHCQAchVPPELYSATTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
29-330 5.50e-41

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 146.86  E-value: 5.50e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15333   7 LAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLSSDIT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLlgWHELGHARppVPGQCRLLASLPF 188
Cdd:cd15333  87 CCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFF--WRQAKAEE--EVSECVVNTDHIL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  189 VLVASGL-TFFLPSGAICFTYCRILLAARKQavqvaslttgmasqasetlqvprtprpgvesadsrrlatkhSRKALKas 267
Cdd:cd15333 163 YTVYSTVgAFYIPTLLLIALYGRIYVEARAR-----------------------------------------ERKATK-- 199
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  268 lTLGILLGMFFVTWLPFFVANIVQAVC-DC--ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15333 200 -TLGIILGAFIVCWLPFFIISLVLPICkDAcwFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQA 264
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
29-331 1.12e-39

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 143.11  E-value: 1.12e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15325   3 LGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWHElgharpPVPGQ---CRLLAS 185
Cdd:cd15325  83 CCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGP-LFGWKE------PAPEDetiCQITEE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 LPFVLVASGLTFFLPSGAICFTYCRILLaarkqavqvaslttgmasqasetlqvprtprpgvesadsrrLATKHSRKAlK 265
Cdd:cd15325 156 PGYALFSALGSFYLPLAIILVMYCRVYV-----------------------------------------VALKFSREK-K 193
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504545  266 ASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG--LFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15325 194 AAKTLGIVVGCFVLCWLPFFLVMPIGSIFPAYKPSdtVFKITFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
35-331 2.09e-39

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 143.16  E-value: 2.09e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAA-NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAML------NALYGrwvlarglCLLWTAFDV 107
Cdd:cd14968   8 VLIAVLSVLgNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILislglpTNFHG--------CLFMACLVL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWHELGHARPPVPG---QCRLLA 184
Cdd:cd14968  80 VLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTP-MFGWNNGAPLESGCGEggiQCLFEE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  185 SLP------FVLVASGLTfflPSGAICFTYCRILLAARKQAVQVASLTTGMASQASetlqvprtprpgvesadsrrlatk 258
Cdd:cd14968 159 VIPmdymvyFNFFACVLV---PLLIMLVIYLRIFRVIRKQLRQIESLLRSRRSRST------------------------ 211
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  259 hSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVC-DCISPG-LFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd14968 212 -LQKEVKAAKSLAIILFLFALCWLPLHIINCITLFCpECKVPKiLTYIAILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
33-331 4.48e-38

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 139.43  E-value: 4.48e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIALICTQPALRNT-SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCS 111
Cdd:cd15104   6 LAVLSPLIITGNLLVIVALLKLIRKKDTkSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITSCA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  112 ASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGwhelGHARPPVPGQCRLLAS--LPFV 189
Cdd:cd15104  86 ASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLISP----QFQQTSYKGKCSFFAAfhPRVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  190 LVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQaSETLQVPRTPrpgvesadsrrlatkhsrkalKASLT 269
Cdd:cd15104 162 LVLSCMVFFPALLLFVFCYCDILKIARVHSRAIYKVEHALARQ-IHPRRTLSDF---------------------KAART 219
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504545  270 LGILLGMFFVTWLPFFVANIVQAVCD--CISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15104 220 VAVLIGCFLLSWLPFQITGLVQALCDecKLYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
28-331 2.18e-37

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 138.12  E-value: 2.18e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLwTAFdV 107
Cdd:cd14993   2 VLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKA-VPY-L 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 M--CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWsLAALASFLPLLLGWH--ELGHARPPVPGQCRLL 183
Cdd:cd14993  80 QgvSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIW-VIAIIIMLPLLVVYEleEIISSEPGTITIYICT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  184 ASLP-------FVLVASGLTFFLPSGAICFTYCRIllaarkqavqvaslttgmasqaseTLQVPRTPRPGVESADSRRLA 256
Cdd:cd14993 159 EDWPspelrkaYNVALFVVLYVLPLLIISVAYSLI------------------------GRRLWRRKPPGDRGSANSTSS 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  257 TKHSRKALKASLTLGILLGMFFVTWLPFFVANIV-------QAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd14993 215 RRILRSKKKVARMLIVVVVLFALSWLPYYVLSILldfgplsSEESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRR 294

                ..
gi 4504545  330 AL 331
Cdd:cd14993 295 GF 296
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
31-331 7.78e-37

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 136.53  E-value: 7.78e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCC 110
Cdd:cd15316   5 IVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDVSFC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  111 SASILNLCLISLDRYLLILSPLRYKLRMT-PLRALALVLgAWSLAALASFLPLLLGWHELGHARPPVP----GQCRLLAS 185
Cdd:cd15316  85 YASLFHLCFISVDRYIAVTDPLVYPTKFTvSVSGICISV-SWIFSLTYSFSVFYTGVNDDGLEELVNAlncvGGCQIILN 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 LPFVLVASgLTFFLPSGAICFTYCRILLAARKQAVQVASlTTGMASQASETLqvprtprpgvesadSRRLAtKHSRKALK 265
Cdd:cd15316 164 QNWVLVDF-LLFFIPTFAMIILYGKIFLVAKQQARKIEM-TSSKAESSSESY--------------KDRVA-RRERKAAK 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  266 aslTLGILLGMFFVTWLPFFVANIVQAVCDCISPGL-FDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15316 227 ---TLGITVIAFLVSWLPYLIDVLIDAFMNFITPPYiYEICCWCAYYNSAMNPLIYALFYPWFRKAI 290
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
35-328 7.57e-36

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 132.65  E-value: 7.57e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGR-WVLARGLCLLWTAFDVMCCSAS 113
Cdd:cd15308   9 LLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYSEFQGGvWTLSPVLCDALMTMDVMLCTAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  114 ILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLA-ALASflPLLLGWHELGHARPPVpgqCRlLASLPFVLVA 192
Cdd:cd15308  89 IFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSfAVAS--PVIFGLNNVPNRDPAV---CK-LEDNNYVVYS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  193 SGLTFFLPSGAICFTYCRILLAARKQavqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsRKALKaslTLGI 272
Cdd:cd15308 163 SVCSFFIPCPVMLVLYCAMFRGLGRE------------------------------------------RKAMR---VLPV 197
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4504545  273 LLGMFFVTWLPFFVANIVQAVCDC--ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFK 328
Cdd:cd15308 198 VVGAFLFCWTPFFVVHITRALCEScsIPPQLISIVTWLGYVNSALNPVIYTVFNAEFR 255
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
28-337 2.43e-35

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 131.88  E-value: 2.43e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGR-WVLARGLCLLWTAFD 106
Cdd:cd15306   2 WAALLILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAmWPLPLVLCPIWLFLD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  107 VMCCSASILNLCLISLDRYLLILSPL---RYKLRMTPLRALALVlgaWSLAALASFlPLLLGWHELGHARpPVPGQCRLL 183
Cdd:cd15306  82 VLFSTASIMHLCAISLDRYIAIKKPIqasQYNSRATAFIKITVV---WLISIGIAI-PVPIKGIETDVDN-PNNITCVLT 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  184 ASL--PFVLVASGLTFFLPSGAICFTYCRILLAARKQAVqvaslttgmasqasetlqvprtprpgvesadsrrlaTKHSR 261
Cdd:cd15306 157 KERfgDFILFGSLAAFFTPLAIMIVTYFLTIHALRKQTI------------------------------------TNEQR 200
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  262 kalkASLTLGILLGMFFVTWLPFFVANIVQAVCDC----ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPC 337
Cdd:cd15306 201 ----ASKVLGIVFFLFLLMWCPFFITNITSVLCDScnqtTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITC 276
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
28-331 1.73e-34

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 129.00  E-value: 1.73e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDV 107
Cdd:cd15309   2 YYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHArppvpgQCrLLASLP 187
Cdd:cd15309  82 MMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISVVWVLSFAISCPLLFGLNNTDQN------EC-IIANPA 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 FVLVASGLTFFLPSGAICFTYCRILLAARKQAvqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsrkalKAS 267
Cdd:cd15309 155 FVVYSSIVSFYVPFIVTLLVYVQIYIVLQKEK---------------------------------------------KAT 189
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  268 LTLGILLGMFFVTWLPFFVANIVQAVCDC-ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15309 190 QMLAIVLGVFIICWLPFFITHILNMHCDCnIPPALYSAFTWLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
28-331 2.29e-33

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 126.90  E-value: 2.29e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIalTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDV 107
Cdd:cd15318   4 YLACAIGMLI--IVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHE--LGHARPPVP--GQCRLL 183
Cdd:cd15318  82 LFCLTSIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSVFLYTKAVEegLAELLTSVPcvGSCQLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  184 AS-----LPFVLvasgltFFLPSGAICFTYCRILLAARKQAVQVASLttgmasqasetlqvprtprpgvesADSRRLATK 258
Cdd:cd15318 162 YNklwgwLNFPV------FFIPCLIMIGLYVKIFIVAKRQARAIASL------------------------LSDTNGASK 211
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504545  259 HSRKALKaslTLGILLGMFFVTWLPFFVANIVQAVCDCISPG-LFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15318 212 RERKAAK---TLGIAVGVYLLCWLPFTIDTMVDSLLNFITPPlLFDIIIWFAYFNSACNPLIYVFSYPWFRKAL 282
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
28-331 4.49e-33

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 126.17  E-value: 4.49e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLClLWTAFDV 107
Cdd:cd14969   2 VLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGC-VIYGFAV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 M-CCSASILNLCLISLDRYLLILSPLRYKlRMTPLRALALVLGAWSLAALASFLPlLLGW----HELGHARppvpgqC-- 180
Cdd:cd14969  81 TfLGLVSISTLAALAFERYLVIVRPLKAF-RLSKRRALILIAFIWLYGLFWALPP-LFGWssyvPEGGGTS------Csv 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  181 ----RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKqavqvaslttgMASQASETLQVPRTprpgvesADSRRLA 256
Cdd:cd14969 153 dwysKDPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRK-----------MSKRAARRKNSAIT-------KRTKKAE 214
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  257 TKHSRKALkasltlgILLGMFFVTWLPF-FVANIVQAVCDCISPGLFDVLTWLGYCNSTM-NPIIYPLFMRDFKRAL 331
Cdd:cd14969 215 KKVAKMVL-------VMIVAFLIAWTPYaVVSLYVSFGGESTIPPLLATIPALFAKSSTIyNPIIYVFMNKQFRRAL 284
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
39-331 1.86e-32

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 123.92  E-value: 1.86e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLC 118
Cdd:cd17790  13 VTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVMNLL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAWsLAALASFLPLLLGWHELGHARPPVPGQCRL-LASLPFVLVASGL-T 196
Cdd:cd17790  93 IISFDRYFSITRPLTYRAKRTPRRAAIMIGLAW-LISFVLWAPAILFWQYLVGERTVLAGQCYIqFLSQPIITFGTAIaA 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  197 FFLPSGAICFTYCRILlaarkqavqvaslttgmasqasetlqvprtprpgvesadsrrlatKHSRKALKASLTLGILLGM 276
Cdd:cd17790 172 FYLPVTIMIILYWRIY---------------------------------------------RETIKEKKAARTLSAILLA 206
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  277 FFVTWLPFFVANIVQAVC-DCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd17790 207 FILTWTPYNIMVLVSTFCkDCVPKTLWELGYWLCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
39-329 1.30e-31

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 121.85  E-value: 1.30e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLC 118
Cdd:cd15301  13 VTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNASVLNLL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLaALASFLPLLLGWHELGHARPPVPGQC--RLLASLPFVLVASGL- 195
Cdd:cd15301  93 IISFDRYFSVTRPLTYRARRTTKKAAVMIASAWII-SLLLWPPWIYSWPYIEGKRTVPAGTCyiQFLETNPYVTFGTALa 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  196 TFFLPSGAICFTYCRILLAARKqavqvaslttgmasqasetlqvprtprpgvesadsrrlatKHSRKALKASLTLGILLG 275
Cdd:cd15301 172 AFYVPVTIMCILYWRIWRETKK----------------------------------------RQKKQESKAAKTLSAILL 211
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  276 MFFVTWLPFFVANIVQAV---CDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15301 212 AFIVTWTPYNVLVLIKAFfpcSDTIPTELWDFSYYLCYINSTINPLCYALCNAAFRR 268
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
29-331 3.01e-30

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 117.82  E-value: 3.01e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15300   3 IAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWsLAALASFLPLLLGWHELGHARPPVPGQCRL-LASLP 187
Cdd:cd15300  83 ASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAW-LISFILWAPPILCWQYFVGKRTVPERECQIqFLSEP 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 FVLVASGL-TFFLPSGAICFTYCRILlaarkqavqvaslttgmasqasetlqvprtprpgvesadsrrlatKHSRKALKA 266
Cdd:cd15300 162 TITFGTAIaAFYIPVSVMTILYCRIY---------------------------------------------KETIKERKA 196
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  267 SLTLGILLGMFFVTWLPFFVANIVQAVC-DCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15300 197 AQTLSAILLAFIITWTPYNIMVLVSTFCsDCIPLTLWHLGYWLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
29-331 3.01e-30

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 118.16  E-value: 3.01e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALtaaANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFdVM 108
Cdd:cd14972   4 VAIVLGVFIVV---ENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSL-VL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWHELGHARPpvpgQC-RLLASLP 187
Cdd:cd14972  80 SLLASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLP-VLGWNCVLCDQE----SCsPLGPGLP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 FVLVASGLT-FFLPSGAICFTYCRILLAARKQAVQVAslttgmasqasetlqvprtprPGVESADSRRLATkhSRKALKa 266
Cdd:cd14972 155 KSYLVLILVfFFIALVIIVFLYVRIFWCLWRHANAIA---------------------ARQEAAVPAQPST--SRKLAK- 210
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  267 slTLGILLGMFFVTWLPFFVANIVQAVC--DCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd14972 211 --TVVIVLGVFLVCWLPLLILLVLDVLCpsVCDIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
31-330 9.45e-29

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 114.76  E-value: 9.45e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAA-ANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGR-WVLARGLCLLWTAFDVM 108
Cdd:cd14979   4 TAIYVAIFVVGIvGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYpWAFGDGGCKLYYFLFEA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLLgWHELGHARPPVPGQ------CRL 182
Cdd:cd14979  84 CTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCA-IPILF-LMGIQYLNGPLPGPvpdsavCTL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  183 LAS----LPFVLVASGLTFFLPSGAICFTYCRILLAARKqavqvaslttgMASQASETLQVPRTPRPGVESADSRRLATK 258
Cdd:cd14979 162 VVDrstfKYVFQVSTFIFFVLPMFVISILYFRIGVKLRS-----------MRNIKKGTRAQGTRNVELSLSQQARRQVVK 230
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  259 hsrkalkaslTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVL-------TWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd14979 231 ----------MLGAVVIAFFVCWLPFHAQRLMFSYASKEDTFLFDFYqylypisGILFYLSSAINPILYNLMSSRFRVA 299
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
29-330 1.41e-28

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 113.35  E-value: 1.41e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15296   3 LAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVDYL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC--RLLASL 186
Cdd:cd15296  83 LCTASVFNIVLISYDRFLSVTRAVSYRAQKGMTRQAVLKMVLVWVLAFLLYGPAIISWEYIAGGSIIPEGECyaEFFYNW 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  187 PFVLVASGLTFFLPSGAICFTYCRILLAARKqavqvaslttgmasqasetlqvprtprpgvesadsRRLATKHSRKALKa 266
Cdd:cd15296 163 YFLMTASTLEFFTPFISVTYFNLSIYLNIQK-----------------------------------RRFRLSRDKKVAK- 206
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  267 slTLGILLGMFFVTWLPFFVANIVQAVCD--CISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15296 207 --SLAIIVCVFGLCWAPYTLLMIIRAACHghCVPDYWYETSFWLLWVNSAINPVLYPLCHMSFRRA 270
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
31-337 3.89e-28

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 112.35  E-value: 3.89e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIAL-TAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMC 109
Cdd:cd15299   7 AFLTGILALvTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  110 CSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWsLAALASFLPLLLGWHELGHARPPVPGQCRL-LASLPF 188
Cdd:cd15299  87 SNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAW-VISFVLWAPAILFWQYFVGKRTVPPDECFIqFLSEPI 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  189 VLVASGL-TFFLPSGAICFTYCRILlaarkqavqvaslttgmasqasetlqvprtprpgvesadsrrlatKHSRKALKAS 267
Cdd:cd15299 166 ITFGTAIaAFYLPVTIMTILYWRIY---------------------------------------------KETIKEKKAA 200
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  268 LTLGILLGMFFVTWLPFFVANIVQAVCD-CISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPC 337
Cdd:cd15299 201 QTLSAILLAFIITWTPYNIMVLVNTFCDsCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLC 271
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
34-331 5.76e-28

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 112.31  E-value: 5.76e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   34 CVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLwtAFDVMCCS-- 111
Cdd:cd15203   8 GLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKL--VPSLQGVSif 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  112 ASILNLCLISLDRYLLILSPLRYklRMTPLRALALVLGAWSLAALASfLPLLLgWHELGHARPPVPGQC----------- 180
Cdd:cd15203  86 VSTLTLTAIAIDRYQLIVYPTRP--RMSKRHALLIIALIWILSLLLS-LPLAI-FQELSDVPIEILPYCgyfcteswpss 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  181 --RLLASLpFVLVasgLTFFLPSGAICFTYCRILLAARKQAVQVASLTTgmasqasetlqvprtprpgvESADSRRLATK 258
Cdd:cd15203 162 ssRLIYTI-SVLV---LQFVIPLLIISFCYFRISLKLRKRVKKKRGKRT--------------------LSSRRRRSELR 217
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  259 HSRKALKasltlgILLGM---FFVTWLPFFVANIV-----QAVCDCISPGLFDVLT-WLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15203 218 RKRRTNR------LLIAMvvvFAVCWLPLNLFNLLrdfepLPQIDGRHFYLIFLIChLIAMSSACVNPLLYGWLNDNFRK 291

                ..
gi 4504545  330 AL 331
Cdd:cd15203 292 EF 293
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
35-331 4.55e-27

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 109.63  E-value: 4.55e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15207   9 LIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWPFGDVMCKLSPLVQGVSVAASV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  115 LNLCLISLDRYLLILSPLRYKlrMTPLRALALVLGAWsLAALASFLP--LLLGWHELGHAR-----------PPVPGQCR 181
Cdd:cd15207  89 FTLVAIAVDRYRAVVHPTEPK--LTNRQAFVIIVAIW-VLALAIMIPqaLVLEVKEYQFFRgqtvhicvefwPSDEYRKA 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  182 LLASLpFVLVasgltFFLPSGAICFTYCRIllaarkqavqvaslttgmasqaseTLQVPRTPRPGVESADSRRLATkHSR 261
Cdd:cd15207 166 YTTSL-FVLC-----YVAPLLIIAVLYVRI------------------------GYRLWFKPVPGGGSASREAQAA-VSK 214
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  262 KALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGL-------FDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15207 215 KKVRVIKMLIVVVVLFALSWLPLHTVTMLDDFGNLSPNQRevlyvyiYPIAHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
30-329 2.68e-26

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 107.52  E-value: 2.68e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   30 AAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMC 109
Cdd:cd14992   4 GVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  110 CSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLlgWHELGHARPPVPGQCRLLASLPFV 189
Cdd:cd14992  84 VYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLY--YATTEVLFSVKNQEKIFCCQIPPV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  190 ----------LVASGLTFFLPSGAICFTYCRIL--LAARKQavqvaslttgmasqasetlqvprtprPGVESADSRRLAT 257
Cdd:cd14992 162 dnktyekvyfLLIFVVIFVLPLIVMTLAYARISreLWFRKV--------------------------PGFSIKEVERKRL 215
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  258 KHSRKALKaslTLGILLGMFFVTWLPFFVANIVQAVCDCISP-----GLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd14992 216 KCKRRVIK---MLVCVVVLFVICWLPFHLFFLLRDFFPLIMKekhtlQVYYFLHWIAMSNSMYNPIIYVTLNNNFRK 289
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
31-335 2.78e-25

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 104.14  E-value: 2.78e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAAA----NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFD 106
Cdd:cd15295   1 VVLLFLMSLLALVivlgNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVID 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  107 VMCCSASILNLCLISLDRYLLILSPLRYKLRMTP-LRALALVLGAWSLAALASFlPLLLGWHELGHARppvpGQC--RLL 183
Cdd:cd15295  81 YLLCTASVYNIVLISYDRYQSVSNAVSYRNQQTAtLRIVTQMVAVWVLAFLVHG-PAILVSDSWKTED----GECepEFF 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  184 ASLPFVLVASGLTFFLPSGAICFTYCRILLAARKqavqvaslttgmasqasetlqvprtprpgvesadsrRLatkhsrKA 263
Cdd:cd15295 156 SNWYILAITSVLEFLVPVILVAYFNTQIYWSLWK------------------------------------RL------RD 193
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504545  264 LKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLT-WLGYCNSTMNPIIYPLFMRDFKRALGRFL 335
Cdd:cd15295 194 RKLAKSLAIILGTFAICWAPYSLFTIIRAACEKHRGSPWYNFAfWLQWFNSFINPFLYPLCHKRFRKAFLKIF 266
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
29-331 3.22e-25

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 104.05  E-value: 3.22e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYG-RWVLARGLCLLWTAFDV 107
Cdd:cd15302   3 LALITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFYTVYVLNGdYWPLGWVLCDLWLSVDY 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALAsFLPLLLGW-HELGHARPPVPGQCRL-LAS 185
Cdd:cd15302  83 TVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALL-FFISIFGWqYFTGQGRSLPEGECYVqFMT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 LPFVLVASGLTFFLPS-GAICFTYCRILLAArkqavqvaslttgmasqasetlqvprtprpgvesadsrrlatKHSRKAL 264
Cdd:cd15302 162 DPYFNMGMYIGYYWTTlIVMLILYAGIYRAA------------------------------------------NRARKAL 199
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  265 KaslTLGILLGMFFVTWLPFFVANIVQAVCD---CISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15302 200 R---TITFILGAFVICWTPYHILATIYGFCEappCVNETLYTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
29-331 5.62e-25

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 103.12  E-value: 5.62e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVialTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15297   6 VAGSLSLV---TIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALAsFLPLLLGWHELGHARPPVPGQCRL-LASLP 187
Cdd:cd15297  83 VSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFIL-WAPAILFWQFIVGGRTVPEGECYIqFFSNA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 FVLVASGL-TFFLPSGAICFTYCRIllaarkqavqvaslttgmasqasetlqvprtprpgvesadsrrlaTKHSRKALKA 266
Cdd:cd15297 162 AVTFGTAIaAFYLPVIIMTVLYWQI---------------------------------------------SRASSREKKV 196
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  267 SLTLGILLGMFFVTWLPFFVANIVQAVC-DCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15297 197 TRTILAILLAFIITWTPYNVMVLINTFCaSCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
31-323 1.34e-23

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 100.14  E-value: 1.34e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCC 110
Cdd:cd14986   5 AVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  111 SASILNLCLISLDRYLLILSPLRYKLRmtPLRALALVLGAWSLAALASfLPLLL--GWHELGHARPpvpgQCRLLASLPF 188
Cdd:cd14986  85 FASTYILVSMSLDRYQAIVKPMSSLKP--RKRARLMIVVAWVLSFLFS-IPQLVifVERELGDGVH----QCWSSFYTPW 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  189 ---VLVASGLT--FFLPSGAICFTYCRILLAARKQAVQVAslTTGMASQASETLQVPRtprpgveSADSRRLATKHSRKA 263
Cdd:cd14986 158 qrkVYITWLATyvFVIPLIILSYCYGRILRTIWIRSRQKT--DRPIAPTAMSCRSVSC-------VSSRVSLISRAKIKT 228
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504545  264 LKASLTlgILLGmFFVTWLPFFVANIVQAVCDcISPGLFDVLTW---LGYCNSTMNPIIYPLF 323
Cdd:cd14986 229 IKMTLV--IILA-FILCWTPYFIVQLLDVYAG-MQQLENDAYVVsetLASLNSALNPLIYGFF 287
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
39-331 8.52e-23

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 97.01  E-value: 8.52e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLC 118
Cdd:cd15298  13 VTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLaALASFLPLLLGWHELGHARPPVPGQCRL-LASLPFVLVASGL-T 196
Cdd:cd15298  93 IISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVL-SFVLWAPAILFWQFVVGKRTVPDNQCFIqFLSNPAVTFGTAIaA 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  197 FFLPSGAICFTYCRILLAARKQAvqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsrkalKASLTLGILLGM 276
Cdd:cd15298 172 FYLPVVIMTVLYIHISLASARER---------------------------------------------KVTRTIFAILLA 206
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  277 FFVTWLPFFVANIVQAVCD-CISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15298 207 FILTWTPYNVMVLVNTFCQsCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTF 262
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
39-328 4.66e-22

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 95.77  E-value: 4.66e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMlnALYGRWVLARGLCLLWTAFDVMCCSASILNLC 118
Cdd:cd15068  13 LAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI--TISTGFCAACHGCLFIACFVLVLTQSSIFSLL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWHElghARPP-----VPGQCR--LLASL-PFVL 190
Cdd:cd15068  91 AIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTP-MLGWNN---CGQPkegknHSQGCGegQVACLfEDVV 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  191 VASGLTFF-------LPSGAICFTYCRILLAARKQAVQVASLTTgMASQASETLQvprtprpgvesadsrrlatkhsrKA 263
Cdd:cd15068 167 PMNYMVYFnffacvlVPLLLMLGVYLRIFLAARRQLKQMESQPL-PGERARSTLQ-----------------------KE 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504545  264 LKASLTLGILLGMFFVTWLPFFVANIVQAVC-DCISPGLF--DVLTWLGYCNSTMNPIIYPLFMRDFK 328
Cdd:cd15068 223 VHAAKSLAIIVGLFALCWLPLHIINCFTFFCpDCSHAPLWlmYLAIVLSHTNSVVNPFIYAYRIREFR 290
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
36-329 4.90e-22

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 95.55  E-value: 4.90e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   36 VIALTA-AANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15393   9 IISLVAvVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVNVSV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  115 LNLCLISLDRYLLILSPLryKLRMTPLRALALVLGAWSLAALASFLPLLLGWHEL------GHARP---PVPGQCRLLAS 185
Cdd:cd15393  89 FTLTVIAVDRYRAVIHPL--KARCSKKSAKIIILIIWILALLVALPVALALRVEEltdktnNGVKPfclPVGPSDDWWKI 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 LPFVLVAsgLTFFLPSGAICFTYCRIllaARKqavqvaslttgmasqasetLQVPRTPRPGVESADSRRLatKHSRKALK 265
Cdd:cd15393 167 YNLYLVC--VQYFVPLVIICYAYTRI---AVK-------------------IWGTKAPGNAQDVRDDEIL--KNKKKVIK 220
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  266 aslTLGILLGMFFVTWLPFFVANIVQAVCDCISPG-----LFDVLTWLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15393 221 ---MLIIVVALFALCWLPLQTYNLLNEIKPEINKYkyiniIWFCSHWLAMSNSCYNPFIYGLYNEKFKR 286
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
34-328 9.44e-22

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 94.46  E-value: 9.44e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   34 CVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALygRWVLARGLCLLWTAFDVMCCSAS 113
Cdd:cd15070   8 ILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSL--GVTIHFYSCLFMSCLLVVFTHAS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  114 ILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLlGWHE----LGHARPPVPGQCRLLASLPFV 189
Cdd:cd15070  86 IMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMF-GWNRkpslESVNTTPLQCQFTSVMRMDYM 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  190 LVASGLTFFL-PSGAICFTYCRILLAARKQAVQvaslttgmasqasetlqvprtprpgveSADSRRLATKHSRKALKASL 268
Cdd:cd15070 165 VYFSFFTWILiPLVIMCALYVDIFYIIRNKLSQ---------------------------NATGFRETGAFYGREFKTAK 217
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  269 TLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFK 328
Cdd:cd15070 218 SLALVLFLFAVCWLPLSIINCVVYFNPKVPKIALYLGILLSHANSMMNPIVYACKIKKFK 277
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
28-320 9.93e-22

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 94.73  E-value: 9.93e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAaaNSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYG-RWVLARGLCLLWTAFD 106
Cdd:cd15392   4 ILMYSTIFVLAVGG--NGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLILqYWPFGEFMCPVVNYLQ 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  107 VMCCSASILNLCLISLDRYLLILSPLRykLRMTPLRALALVLGAWSLAALASfLPLLLgwhelgHAR--PPVPGQC---- 180
Cdd:cd15392  82 AVSVFVSAFTLVAISIDRYVAIMWPLR--PRMTKRQALLLIAVIWIFALATA-LPIAI------TSRlfEDSNASCgqyi 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  181 ------RLLASLPFVLVASGLTFFLPSGAICFTYCRIllaarkqAVQVaslttgmasqasetlQVPRTPRPGVESADSRR 254
Cdd:cd15392 153 cteswpSDTNRYIYSLVLMILQYFVPLAVLVFTYTRI-------GIVV---------------WAKRTPGEAENNRDQRM 210
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  255 LATKhsRKALKASLTLGILlgmFFVTWLPFFVANIVQAVCDCIS-----PGLFDVLTWLGYCNSTMNPIIY 320
Cdd:cd15392 211 AESK--RKLVKMMITVVAI---FALCWLPLNILNLVGDHDESIYswpyiPYLWLAAHWLAMSHCCYNPFIY 276
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
28-331 1.08e-21

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 94.66  E-value: 1.08e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTA-AANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNaLYGR--WVLARGLCLLWTA 104
Cdd:cd14997   1 VLVSVVYGVIFVVGvLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVE-TWARepWLLGEFMCKLVPF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  105 FDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALAS----FLPLLLGWHELGHARPPVpgqC 180
Cdd:cd14997  80 VELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSspvlFITEFKEEDFNDGTPVAV---C 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  181 RLLA----SLPFVLVASGLTFFLPSGAICFTYCRIllaARKqAVQVASLTTGMASQASEtlqvprtprpgvesadsrrlA 256
Cdd:cd14997 157 RTPAdtfwKVAYILSTIVVFFVVPLAILSGLYSVI---CRR-LVGHPALESRRADAANR--------------------H 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  257 TKHSRKALKASLTLGILLgmFFVTWLPFFVAN---IVQAVCDCISPGLFDVLTWLGYC------NSTMNPIIYPLFMRDF 327
Cdd:cd14997 213 TLRSRRQVVYMLITVVVL--FFVCLLPFRVVTlwiIFAPDEDLQALGLEGYLNLLVFCrvmvylNSALNPILYNLMSTKF 290

                ....
gi 4504545  328 KRAL 331
Cdd:cd14997 291 RSAF 294
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
29-331 1.12e-21

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 94.49  E-value: 1.12e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15202   3 LIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYC 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLryKLRMTPLRALALVLGAWSLAALASF-LPLLLGWHELGHARPPVPGQCR------ 181
Cdd:cd15202  83 SVHVSAYTLTAIAVDRYQAIMHPL--KPRISKTKAKFIIAVIWTLALAFALpHAICSKLETFKYSEDIVRSLCLedwper 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  182 -LLASLPFVLVASGLTFFLPSGAICFTYCRILLaarkqavqvaslttgmasqaseTLQVPRTPRPGVESADSRRLATKhs 260
Cdd:cd15202 161 aDLFWKYYDLALFILQYFLPLLVISFAYARVGI----------------------KLWASNMPGDATTERYFALRRKK-- 216
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  261 RKALKASLTLGILlgmFFVTWLPFFVANI-----VQAVCDCIsPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15202 217 KKVIKMLMVVVVL---FALCWLPFNIYVLllsskPDYLIKTI-NAVYFAFHWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
29-330 1.43e-21

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 93.58  E-value: 1.43e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15213   3 LAILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYWF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLIlspLRYKLRMTPLRALALVLGAWSLAALASFlPLLLGWHELG-HARPP--VPGQCRLLAS 185
Cdd:cd15213  83 FVLEGVAILLIISVDRYLII---VQRQDKLNPHRAKILIAVSWVLSFCVSF-PPLVGWGKYEfPPRAPqcVLGYTESPAD 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 LPFVLVASGLTFFLPSGAICFTYCRILLAARkqavqvaSLTTgmasqasetlqvprtprpgvesadsrrlatkhsrkalK 265
Cdd:cd15213 159 RIYVVLLLVAVFFIPFLIMLYSYFCILNTVR-------SFKT-------------------------------------R 194
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  266 ASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG--LFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15213 195 AFTTILILFIGFSVCWLPYTVYSLLSVFSRYSSSFyvISTCLLWLSYLKSAFNPVIYCWRIKKFREA 261
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
31-331 2.14e-21

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 93.91  E-value: 2.14e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAAAN-SLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMC 109
Cdd:cd15382   5 IVYSVLFLIAAVGNlTVLLILLRNRRRKRSRVNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRLMLFFRAFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  110 CSASILNLCLISLDRYLLILSPLRykLRMTPLRALALVLGAWSLAALASfLPLLLGWHELGHarPPVPG--QCRLLASLP 187
Cdd:cd15382  85 LYLSSFVLVCISLDRYFAILKPLR--LSDARRRGRIMLAVAWVISFLCS-IPQSFIFHVESH--PCVTWfsQCVTFNFFP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 -------FVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTtgmaSQASETLQVPRTPRPGVESADSRRLatkhs 260
Cdd:cd15382 160 shdhelaYNIFNMITMYALPLIIIVFCYSLILCEISRKSKEKKEDV----SEKSSSVRLRRSSVGLLERARSRTL----- 230
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  261 rkalkaSLTLGILLgMFFVTWLPFFVANIVQAV----CDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15382 231 ------KMTIVIVL-VFIICWTPYFIMSLWYWFdresASKVDPRIQKGLFLFAVSNSCMNPIVYGYFSIDLRREL 298
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
29-330 3.39e-21

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 92.33  E-value: 3.39e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAA-ANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDV 107
Cdd:cd15210   2 FAAVWGIVFMVVGVpGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWsLAALASFLPLLLG-WHELGHArpPVPGQCRLLA-- 184
Cdd:cd15210  82 GLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTW-IFSFGSFLPLWLGiWGRFGLD--PKVCSCSILRdk 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  185 ---SLPFVLVASGltFFLPSGAICFTYCRillaarkqavqvaslttgmasqasetlqvprtprpgvesadsrrlatkhsR 261
Cdd:cd15210 159 kgrSPKTFLFVFG--FVLPCLVIIICYAR--------------------------------------------------R 186
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  262 KALKASLTLGILLGMFFVTWLPFFVANIVQAvcDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15210 187 EDRRLTRMMLVIFLCFLVCYLPITLVNVFDD--EVAPPVLHIIAYVLIWLSSCINPIIYVAMNRQYRQA 253
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
44-330 4.95e-21

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 92.36  E-value: 4.95e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLD 123
Cdd:cd15096  18 NSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVYTLVLMSLD 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  124 RYLLILSPLRYKLRMTPLRALALVLGAWSLaALASFLPLLL--GWHELGHARPPVpGQCRLLASLPFVLVASGLTFF--- 198
Cdd:cd15096  98 RYLAVVHPITSMSIRTERNTLIAIVGIWIV-ILVANIPVLFlhGVVSYGFSSEAY-SYCTFLTEVGTAAQTFFTSFFlfs 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  199 --LPSGAICFTYCRILLAARKQAVQVAslttgmasqasetlqvprtpRPGVESADSRRLATKhsrkalkaslTLGILLGM 276
Cdd:cd15096 176 ylIPLTLICVLYMLMLRRLRRQKSPGG--------------------RRSAESQRGKRRVTR----------LVVVVVVV 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  277 FFVTWLPFFVANIVQAVcDCISPGLFDVLT-----WLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15096 226 FAICWLPIHIILLLKYY-GVLPETVLYVVIqilsnCLAYGNSCVNPILYAFLSQNFRKA 283
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
29-331 1.17e-20

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 90.97  E-value: 1.17e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTA-AANSLLIALICTQPALRNTSnfFLVSLFTSDLMVGLVVMPPAML--NALYGRWVLARGLCLLWTAF 105
Cdd:cd15220   1 VGLFCMVLLDLTAlVGNTAVMVVIAKTPHLRKFA--FVCHLCVVDLLAALLLMPLGILssSPFFLGVVFGEAECRVYIFL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  106 DVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWHELGHARPPVPGQCRLLAS 185
Cdd:cd15220  79 SVCLVSASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLP-VLGWPSYGGPAPIAARHCSLHWS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 L-----PFVLVASGLTFFLPSGAICFTYCRILLAarkqavqvasLTTGmasqasetlqvprtprpgvesadsrrlatkhs 260
Cdd:cd15220 158 HsghrgVFVVLFALVCFLLPLLLILVVYCGVFKV----------FGGG-------------------------------- 195
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504545  261 rkalKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG--LFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15220 196 ----KAALTLAAIVGQFLCCWLPYFAFHLYSALAASPVSGgeAEEVVTWLAYSCFAVNPFFYGLLNRQIREEL 264
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
44-320 2.77e-20

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 90.71  E-value: 2.77e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLD 123
Cdd:cd15079  18 NGLVIYIFSTTKSLRTPSNMLVVNLAISDFLM-MIKMPIFIYNSFYEGWALGPLGCQIYAFLGSLSGIGSIWTNAAIAYD 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  124 RYLLILSPLRyKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELgharppVP----GQC------RLLASLPFVLVAS 193
Cdd:cd15079  97 RYNVIVKPLN-GNPLTRGKALLLILFIWLYALPWALLPLLFGWGRY------VPegflTSCsfdyltRDWNTRSFVATIF 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  194 GLTFFLPSGAICFTYCRILLAARKQAVQvaslttgMASQASetlqvprtpRPGVESadSRRLATKHSRKA----LKASLT 269
Cdd:cd15079 170 VFAYVIPLIIIIYCYSFIVKAVFAHEKA-------LREQAK---------KMNVVS--LRSNADANKQSAeiriAKVALT 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  270 lgiLLGMFFVTWLPFFVANIVQAVCDC--ISPGlfdvLTWLGYC----NSTMNPIIY 320
Cdd:cd15079 232 ---NVFLWFIAWTPYAVVALIGAFGNQslLTPL----VSMIPALfaktAACYNPIVY 281
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
35-328 5.97e-20

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 89.61  E-value: 5.97e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALyGRWVLARGlCLLWTAFDVMCCSASI 114
Cdd:cd15069   9 IIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISL-GFCTDFHS-CLFLACFVLVLTQSSI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWHELGHARP--PVPGQ-------CRLLAS 185
Cdd:cd15069  87 FSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTP-FLGWNKAMSATNnsTNPADhgtnhscCLISCL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 LPFVLVASGLTFF-------LPSGAICFTYCRILLAARKQAVQvasltTGMASQASETLQvprtprpgvesadsrrlatk 258
Cdd:cd15069 166 FENVVPMSYMVYFnffgcvlPPLLIMLVIYIKIFLVACRQLQR-----TELMDHSRTTLQ-------------------- 220
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504545  259 hsrKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG----LFDVLTWLGYCNSTMNPIIYPLFMRDFK 328
Cdd:cd15069 221 ---REIHAAKSLAIIVGIFALCWLPVHILNCITLFQPEFSKSkpkwAMNVAILLSHANSVVNPIVYAYRNRDFR 291
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
28-331 1.50e-19

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 88.10  E-value: 1.50e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLClLWTAFDV 107
Cdd:cd15074   2 IIGIYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGC-VFYGFCG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 MCCS-ASILNLCLISLDRYLLILSPlRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWhelGHARP-PVPGQCRL--- 182
Cdd:cd15074  81 FLFGcCSINTLTAISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFWAVAP-LVGW---GSYGPePFGTSCSIdwt 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  183 -----LASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQavqvaslttgmasqasetlqvprtpRPGVESADSRRLA- 256
Cdd:cd15074 156 gasasVGGMSYIISIFIFCYLLPVLIIVFSYVKIIRKVKSS-------------------------RKRVAGFDSRSKRq 210
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  257 TKHSRKALKASLTlgILLGmFFVTWLPFFVANIVQAV--CDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15074 211 HKIERKVTKVAVL--ICAG-FLIAWTPYAVVSMWSAFgsPDSVPILASILPALFAKSSCMYNPIIYLLFSSKFRQDL 284
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
44-331 2.54e-19

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 87.76  E-value: 2.54e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAM-LNALYGRWVLARGLCLLW----TAFDVMccsaSILNLC 118
Cdd:cd15337  18 NLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNGFPLKtISSFNKKWIWGKVACELYgfagGIFGFM----SITTLA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLlGWHelghARPPVPGQC--------RLLASLPFVL 190
Cdd:cd15337  94 AISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFF-GWG----RYVPEGFQTsctfdylsRDLNNRLFIL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  191 VASGLTFFLPSGAICFTYCRILLAARKQA-VQVASLTTGMASQasetlqvprtprpgvesadsRRLATKHSRKALKASLT 269
Cdd:cd15337 169 GLFIFGFLCPLLIIIFCYVNIIRAVRNHEkEMTQTAKSGMGKD--------------------TEKNDARKKAEIRIAKV 228
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504545  270 LGILLGMFFVTWLPF-FVANIVQA-VCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15337 229 AIILISLFLLSWTPYaVVALLGQFgPAYWITPYVSELPVMFAKASAIYNPIIYALSHPKFRAAL 292
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
28-330 2.74e-19

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 87.83  E-value: 2.74e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIAL-ICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFD 106
Cdd:cd15208   1 WVLIALYILVFIVGLVGNVLVCFaVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  107 VMCCSASILNLCLISLDRYLLILSPLRYKLrmTPLRALALVLGAWsLAALASFLPLLLgWHELGHARPPVPGQCRLLASL 186
Cdd:cd15208  81 TVSVSVSVLTLSCIALDRWYAICHPLMFKS--TAKRARVSILIIW-IVSLLIMIPQAI-VMECSRVVPLANKTILLTVCD 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  187 P--------------FVLVasglTFFLPSGAICFTYCRIllaARKqavqvasLTTGMASQASETLQVPRT-PRPGVESAD 251
Cdd:cd15208 157 ErwsdsiyqkvyhicFFLV----TYLLPLCLMILAYFQI---FRK-------LWCRQIPGTSSVVQRKWNkPRKSAVAAE 222
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  252 SRRLatkHSRKalKASLTLGILLGMFFVTWLPFFVANIVQAVCDCIS------PGLFDVLTWLGYCNSTMNPIIYPLFMR 325
Cdd:cd15208 223 EKQL---RSRR--KTAKMLIVVVIMFAICYLPVHLLNILRYVFGLFTvdretiYAWFLFSHWLVYANSAINPIIYNFMSG 297

                ....*
gi 4504545  326 DFKRA 330
Cdd:cd15208 298 KFREE 302
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
36-328 1.27e-18

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 85.98  E-value: 1.27e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   36 VIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAmlnaLYGRW-----VLARGLCLLWTAFDVMCC 110
Cdd:cd15358  10 IFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLE----LYEMWsnypfLLGAGGCYFKTLLFETVC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  111 SASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLP--LLLGWHEL-GHARPPVPGQ--CRLLAS 185
Cdd:cd15358  86 FASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCS-IPntSLHGIFQLtVPCRGPVPDSatCMLVKP 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 LPF----VLVASGLTFFLPSGAICFTYCRILLAARKQA-VQVASLTTGMASQASETLQVPRTPRpgvesadSRRLATKhs 260
Cdd:cd15358 165 RWMynliIQITTLLFFFLPMGTISVLYLLIGLQLKREKmLLVLEAKGSKAGDSYQHRRIQQEKR-------RRRQVTK-- 235
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  261 rkalkaslTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTW-------LGYCNSTMNPIIYPLFMRDFK 328
Cdd:cd15358 236 --------MLFVLVVVFGICWAPFHTDRLMWSFISQWTGELHLAFQYvhiisgvFFYLSSAANPVLYNLMSTRFR 302
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
29-331 1.99e-18

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 85.18  E-value: 1.99e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15397   3 LVVSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQCM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKlrMTPLRALALVLGAWSLAALASfLPLLLG-------WHELGHARPP------ 175
Cdd:cd15397  83 SVTVSILSLVLIALERHQLIINPTGWK--PSVSQAYLAVVVIWMLACFIS-LPFLAFhiltdepYKNLSHFFAPladkav 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  176 ----VPGQCRLLASLPFVLVasgLTFFLPSGAICFTYCRILLAARKQavqvasltTGMASQASEtlqvprtprpgvesaD 251
Cdd:cd15397 160 ctesWPSEHHKLAYTTWLLL---FQYCLPLLFILVCYLRIYLRLRRR--------KDMLERRGE---------------Y 213
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  252 SRRLatKHSRkalKASLTLGILLGMFFVTWLPFFVANIV-----QAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRD 326
Cdd:cd15397 214 NRRA--GHSK---RINVMLVSLVAAFALCWLPLNVFNAIadwnhEAIPHCQHNLIFSLCHLAAMASTCVNPIIYGFLNSN 288

                ....*
gi 4504545  327 FKRAL 331
Cdd:cd15397 289 FKKEV 293
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
32-330 2.36e-18

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 84.87  E-value: 2.36e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   32 ALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCS 111
Cdd:cd15391   6 LYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  112 ASILNLCLISLDRYLLILSPLRYklRMTPLRALALVLGAWSLAALASFLPLLLG------WHELG----HARPPVPGQCR 181
Cdd:cd15391  86 ASVLTNTAIGIDRFFAVIFPLRS--RHTKSRTKCIIASIWAISFSLSSVQLFAGrtqrygQYSEGrvlcGESWPGPDTSR 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  182 LLASLpFVLVasgLTFFLPSGAICFTYCRIllaarkqavqvaslttgmasqaSETLQVPRTPRPGVESADSRRLATKhsR 261
Cdd:cd15391 164 SAYTV-FVML---LTYIIPLLILTSTYGYV----------------------GFRLWNRTAPGNADKGRDDMQIKSK--R 215
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  262 KALKaslTLGILLGMFFVTWLPFFVANIVQAVCDCISP-------GLFDVLTWLGYCNSTMNPIIYpLFMRDFKRA 330
Cdd:cd15391 216 KVIK---MLVFVVLMFGICWLPLHLFNLVQDFSTVFRNmpqhttrLIYGACHWIAMSNSFVNPIIY-LFMNDSFRS 287
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
29-330 4.05e-18

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 84.51  E-value: 4.05e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15403   3 LAIVMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLYWF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLIlspLRYKLRMTPLRALALVLGAWSLAALASFlPLLLGWHEL-GHARPP--VPGQCRLLAS 185
Cdd:cd15403  83 FVLEGVAILLIISVDRFLII---VQRQDKLNPHRAKVMIAISWVLSFCISF-PSVVGWTLVeVPARAPqcVLGYTESPAD 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 LPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADsrrLATKhsrkaLK 265
Cdd:cd15403 159 RVYAVLLVVAVFFVPFSIMLYSYLCILNTVRRNAVRIHNHADSLCLSQVSKLGLMGLQRPHQMNVD---MSFK-----TR 230
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  266 ASLTLGILLGMFFVTWLPFFVANIVQAVCDCI--SPGLFDVLT---WLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15403 231 AFTTILILFVGFSLCWLPHTVFSLLSVFSRRFyySSSFYPISTcvlWLSYLKSVFNPVIYCWRIKKFREA 300
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
29-330 7.50e-18

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 83.28  E-value: 7.50e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd14971   3 VPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLLgWHELGHARPPVPGQCRLLASLPF 188
Cdd:cd14971  83 SMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVA-APVLA-LHRLRNYTPGNRTVCSEAWPSRA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  189 VLVASGLTFF-----LPSGAICFTYCRILlaarkqavqvaslttgmasqasetLQVPRTPRPGVESADSRRLATKHSRKA 263
Cdd:cd14971 161 HRRAFALCTFlfgylLPLLLICVCYAAML------------------------RHLWRVAVRPVLSEGSRRAKRKVTRLV 216
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  264 LkasltlgILLGMFFVTWLPFFVANIVQAVCDC-ISPGLFDVLTW---LGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd14971 217 L-------VVVVLFAACWGPIHAILLLVALGPFpLTYATYALRIWahcLAYSNSAVNPVLYAFLSEHFRKA 280
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
33-331 2.10e-17

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 81.90  E-value: 2.10e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIALICTQPALRnTSNFFLV-SLFTSDLMVGLVVMppamLNALYGRWVLARGLCLLWTAFDVMCCS 111
Cdd:cd15962   7 LCISGTVIACENAIVVAIIFYTPTLR-TPMFVLIgSLATADLLAGCGLI----LNFVFQYVIQSETISLITVGFLVASFT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  112 ASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWHELGH------ARPPVPGQCRLLAS 185
Cdd:cd15962  82 ASVSSLLAITVDRYLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLGLLP-VLGWNCLEErascsiVRPLTKSNVTLLSA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 LPFVLVASGLTFFLpsgAICFTYCRillAARKQAVQVASLTTgmasqasetlqvprtprpgvesadSRRLATKhsrkalK 265
Cdd:cd15962 161 SFFFIFILMLHLYI---KICKIVCR---HAHQIALQQHFLTA------------------------SHYVATK------K 204
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  266 ASLTLGILLGMFFVTWLPFfvaNIVQAVCDCISPGLFDVLTWL-GYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15962 205 GVSTLAIILGTFGASWLPF---AIYCVVGDHEYPAVYTYATLLpATYNSMINPIIYAYRNQEIQRSM 268
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
32-331 3.02e-17

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 81.61  E-value: 3.02e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   32 ALCVVIALTAaaNSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLwTAFDV-MCC 110
Cdd:cd15083   8 LIIGLIGVVG--NGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDM-YGFSGgLFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  111 SASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLLGWHelGHARPPVPGQC------RLLA 184
Cdd:cd15083  85 IMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWV-LPPLFGWS--RYVLEGLLTSCsfdylsRDDA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  185 SLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVAslttGMASQASETLQVPRTPRPGVESadsrrlatkhsrKAL 264
Cdd:cd15083 162 NRSYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAMK----EMAKRFSKSELSSPKARRQAEV------------KTA 225
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  265 KASLTLGILlgmFFVTWLPF-FVANIVQA-VCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15083 226 KIALLLVLL---FCLAWTPYaVVALIGQFgYLEVLTPLATAIPAAFAKTSAIYNPVIYAFSHPKFRRAL 291
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
35-330 3.40e-17

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 81.43  E-value: 3.40e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAA-ANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARglCLLWTAFDVMCCSAS 113
Cdd:cd15071   8 VLIALVSVpGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEFYS--CLMVACPVLILTQSS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  114 ILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWHELG-----------HARPPVPGQCRL 182
Cdd:cd15071  86 ILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTP-MFGWNNLNaverawaanssMGELVIKCQFET 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  183 LASLPFVLVASGLTFFLPSgaicftycrILLaarkqavqvaslttgMASQASETLQVPRTPRPGVESADSRRlATKHSRK 262
Cdd:cd15071 165 VISMEYMVYFNFFVWVLPP---------LLL---------------MLLIYLEVFYLIRKQLNKKVSSSSSD-PQKYYGK 219
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  263 ALKASLTLGILLGMFFVTWLPFFVANIVQAVC-DCISPGLFD-VLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15071 220 ELKIAKSLALILFLFALSWLPLHILNCITLFCpSCKKPMILTyIAIFLTHGNSAMNPIVYAFRIKKFRTT 289
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
29-331 3.42e-17

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 81.17  E-value: 3.42e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAaaNSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15001   4 IVYVITFVLGLIG--NSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFlPLLLGW---HELGHARPPVPGQCRLLAS 185
Cdd:cd15001  82 SFICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILAS-PVLFGQglvRYESENGVTVYHCQKAWPS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 LPFVLVASG----LTFFLPSGAICFTYCRIllaARKQAVQvaslttgmasqasetlqvprtprpgvesadsrrlatkhsr 261
Cdd:cd15001 161 TLYSRLYVVylaiVIFFIPLIVMTFAYARD---TRKQVIK---------------------------------------- 197
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  262 kalkaslTLGILLGMFFVTWLPFFVANIVQA--VCDCISPGLFD----VLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15001 198 -------MLISVVVLFAVCWGPLLIDNLLVSfdVISTLHTQALKymriAFHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
33-324 3.84e-17

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 81.33  E-value: 3.84e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSA 112
Cdd:cd15384   7 LAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFGLYL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  113 SILNLCLISLDRYLLILSPLRyKLRMtPLRALALVLGAWSLAALASfLPLLLGWHELGHARPPVPGQCR----------- 181
Cdd:cd15384  87 STYITVLISLDRCVAILYPMK-RNQA-PERVRRMVTVAWILSPIFS-IPQAVIFHVERGPFVEDFHQCVtygfytaewqe 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  182 -LLASLPFVLvasglTFFLPSGAICFTYCRILLAARKqavqvasltTGMASQASETLQVPRTPrpgvesaDSRRLATKHS 260
Cdd:cd15384 164 qLYNMLSLVF-----MFPIPLVIMVTCYVLIFITLSK---------SSRDFQGLEIYTRNRGP-------NRQRLFHKAK 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  261 RKALKasLTLGILLGmFFVTWLPFFVANIVQAVCDC--ISPGLFDVLTWLGYCNSTMNPIIYPLFM 324
Cdd:cd15384 223 VKSLR--MSAVIVTA-FILCWTPYYVIMIWFLFFNPypLNDILFDVIFFFGMSNSCVNPLIYGAFH 285
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
27-330 7.86e-17

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 80.13  E-value: 7.86e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   27 GWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFD 106
Cdd:cd15206   1 ELIIPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  107 VMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWsLAALASFLPLLLgWHELGHARPPVPGQCRLL--- 183
Cdd:cd15206  81 AVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIW-LLSFLIMSPILV-FSNLIPMSRPGGHKCREVwpn 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  184 --ASLPFVLVASGLTFFLPSGAICFTY---CRILLAARKQAVQVaslttgmasqasetlqvprtprpgvesadsrrlatk 258
Cdd:cd15206 159 eiAEQAWYVFLDLMLLVIPGLVMSVAYgliSWTLLEAKKRVIRM------------------------------------ 202
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  259 hsrkalkasltLGILLGMFFVTWLPFFVANIVQA-----VCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15206 203 -----------LFVIVVEFFICWTPLYVINTWKAfdppsAARYVSSTTISLIQLLAYISSCVNPITYCFMNKRFRQA 268
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
35-331 1.22e-16

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 79.85  E-value: 1.22e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSD--LMVGLVVMppAMLNALYgRWVLARGLCLLWTAFDVMCCSA 112
Cdd:cd15972   9 VVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADelFMLGLPFL--AAQNALS-YWPFGSFMCRLVMTVDAINQFT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  113 SILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALAsFLPLLL-----GWHELGHARPPVPGQCRLLAslp 187
Cdd:cd15972  86 SIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLV-VLPVVIfsgvpGGMGTCHIAWPEPAQVWRAG--- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 FVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVaslttgmasqasetlqvprtprpgvesadsRRLATKHSRKALKAS 267
Cdd:cd15972 162 FIIYTATLGFFCPLLVICLCYLLIVVKVRSSGRRV------------------------------RATSTKRRGSERKVT 211
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504545  268 LTLGILLGMFFVTWLPFFVANIVQAVCDCISP----GLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15972 212 RMVVIVVAAFVLCWLPFYALNIVNLVCPLPEEpslfGLYFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
30-320 1.50e-16

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 79.43  E-value: 1.50e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   30 AAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGR-WVLARGLCLLWTAFDVM 108
Cdd:cd15212   4 ALVLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPgWLFGDRLCLANGFFNAC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKlrMTPLRALALVLGAWsLAALASFLPlllgWHELGHARPPV------------ 176
Cdd:cd15212  84 FGIVSTLTMTLISFDRYYAIVRQPQGK--IGRRRALQLLAAAW-LTALGFSLP----WYLLASAPEYYeklgfyhclyvl 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  177 -PGQCRLLASLPFVLVAsgLTFFLPSGAICFTYCRILLAARKQAVQVASLTtgmasqasetlqvprTPRPGVESADSRRL 255
Cdd:cd15212 157 hSGPSRLGAAYSSVLIV--LCYLLPFALMCFCHYNICKTVRLSESRVRPVT---------------TYAHLLRFYSEMRT 219
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  256 ATkhsrkalkaslTLGILLGMFFVTWLPFFVANIVQAVCDC-ISPGLFDVLTWLGYCNSTMNPIIY 320
Cdd:cd15212 220 AT-----------TVLIMIVFIICCWGPYCLLGLVAAAGGYqFPPLMDTVAIWMAWANGAINPLIY 274
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
33-329 1.61e-16

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 79.75  E-value: 1.61e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPpamLNALYGrwvlargLCLLWTAFDVMC--- 109
Cdd:cd15195   7 TWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMP---MDAVWN-------YTVEWLAGDLMCrvm 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  110 -------CSASILNLCLISLDRYLLILSPLryKLRMTPLRALALVLGAWSLAALASFLPLLLgwHELGHARPPVPG--QC 180
Cdd:cd15195  77 mflkqfgMYLSSFMLVVIALDRVFAILSPL--SANQARKRVKIMLTVAWVLSALCSIPQSFI--FSVLRKMPEQPGfhQC 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  181 RLLASL-------PFVLVASGLTFFLPSGAICFTYCRILLAARKqavqvaslttgMASQASETLQVPRTPRpgvesadSR 253
Cdd:cd15195 153 VDFGSAptkkqerLYYFFTMILSFVIPLIITVTCYLLILFEISK-----------MAKRARDTPISNRRRS-------RT 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  254 RLATKHSRKALKASLTLGIllgMFFVTWLPFFVANIV----QAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15195 215 NSLERARMRTLRMTALIVL---TFIVCWGPYYVLGLWywfdKESIKNLPPALSHIMFLLGYLNPCLHPIIYGVFMKEIRN 291
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
29-331 1.89e-16

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 79.38  E-value: 1.89e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWtAFdvm 108
Cdd:cd15336   3 VGSVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELY-AF--- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 cCSA-----SILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWsLAALASFLPLLLGWHELgharppVPGQcrLL 183
Cdd:cd15336  79 -CGAlfgitSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVW-LYSLAWSLPPLFGWSAY------VPEG--LL 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  184 ASLPFVLVASGLT------------FFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQvprtprpgvesad 251
Cdd:cd15336 149 TSCTWDYMTFTPSvraytmllfcfvFFIPLGIIIYCYLFIFLAIRSTGREVQKLGSQDRKEKAKQYQ------------- 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  252 SRRLATKHSRKALkasltlgILLGMFFVTWLPFFVANIVQ--AVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15336 216 RMKNEWKMAKIAF-------VVILLFVLSWSPYACVALIAwaGYAHLLTPYMKSVPAVIAKASAIYNPIIYAITHPKYRE 288

                ..
gi 4504545  330 AL 331
Cdd:cd15336 289 AI 290
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
35-331 1.98e-16

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 79.19  E-value: 1.98e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVmPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15970   9 VVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSV-PFLVTSTLLRHWPFGSLLCRLVLSVDAINMFTSI 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALAsFLPLLLGWHELGHARPPVpgQCRLLASLP------- 187
Cdd:cd15970  88 YCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILV-ILPIIIFSNTAPNSDGSV--ACNMQMPEPsqrwlav 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 FVLVASGLTFFLPSGAICFTYCRILLAARkqavqVASLTTGMAsqasetlQVPRTPRpgvesadsrrlatkhsrkalKAS 267
Cdd:cd15970 165 FVVYTFLMGFLLPVIAICLCYILIIVKMR-----VVALKAGWQ-------QRKRSER--------------------KIT 212
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504545  268 LTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15970 213 LMVMMVVTVFVICWMPFYVVQLVSVFVGQHDATVSQLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
28-331 3.02e-16

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 78.86  E-value: 3.02e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTA-AANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMP-PAMLNALYGrWVLARGLCLLWTAF 105
Cdd:cd15095   1 WLVPLIFAIIFLVGlAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPfTAALYATPS-WVFGDFMCKFVNYM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  106 DVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLL-------GWHELGH-ARPPVP 177
Cdd:cd15095  80 MQVTVQATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLS-IPVAIyyrleegYWYGPQTyCREVWP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  178 GQcrlLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTtgmaSQASEtlqvprtprpgvesadsRRLAT 257
Cdd:cd15095 159 SK---AFQKAYMIYTVLLTYVIPLAIIAVCYGLILRRLWRRSVDGNNQS----EQLSE-----------------RALRQ 214
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  258 KhsRKALKASLTLGILlgmFFVTWLPFFVANIVQAVCDC--ISPGLFDVLTW---LGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15095 215 K--RKVTRMVIVVVVL---FAICWLPNHVLNLWQRFDPNfpETYATYALKIAalcLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
29-330 3.69e-16

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 78.73  E-value: 3.69e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAmlnaLYGRW-----VLARGLCLLWT 103
Cdd:cd15133   3 VCLTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLE----LYELWqnypfLLGSGGCYFKT 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  104 AFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLgwHELGHARPPVPG--QCR 181
Cdd:cd15133  79 FLFETVCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPNTSL--HGIKFLGSGVPAsaQCT 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  182 LL---ASLPFVLVASGLTFF-LPSGAICFTYCRILLAARKQAvqvaslttGMASQASETLQVPRTPRpgvesadsrrlAT 257
Cdd:cd15133 157 VRkpqAIYNMIPQHTGHLFFvLPMAVISVLYLLMALRLARER--------GLDATGAGSKIGTRTGQ-----------LL 217
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  258 KHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTW-------LGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15133 218 QHPRTRAQVTKMLFILVVVFAICWAPFHIDRLMWSFISDWTDNLHEVFQYvhiisgvFFYLSSAVNPILYNLMSTRFREM 297
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
44-331 4.72e-16

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 78.19  E-value: 4.72e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLmvGLVVMPP--AMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLIS 121
Cdd:cd14985  18 NLFVVWVFLFPRGPKRVADIFIANLAAADL--VFVLTLPlwATYTANQYDWPFGAFLCKVSSYVISVNMFASIFLLTCMS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  122 LDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLLgWHELGharpPVPG----QCRLL-----ASLPFVLVA 192
Cdd:cd14985  96 VDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLS-LPTFL-LRSLQ----AIENlnktACIMLypheaWHFGLSLEL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  193 SGLTFFLPSGAICFTYCRILLAARKqavqvaslttgmasqasetlqvprtprpgvesadsRRLATKHSRKALKASLTL-G 271
Cdd:cd14985 170 NILGFVLPLLIILTCYFHIARSLRK-----------------------------------RYERTGKNGRKRRKSLKIiF 214
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  272 ILLGMFFVTWLPF------FVANIVQAVCDCISPGLFD----VLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd14985 215 ALVVAFLVCWLPFhffkflDFLAQLGAIRPCFWELFLDlglpIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
35-331 9.43e-16

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 77.19  E-value: 9.43e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSD--LMVGLVVMppAMLNALYgRWVLARGLCLLWTAFDVMCCSA 112
Cdd:cd15971   9 VVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADelFMLGLPFL--AIQVALV-HWPFGKAICRVVMTVDGINQFT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  113 SILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARppvpGQCRLLASLP----- 187
Cdd:cd15971  86 SIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGR----SSCTIIWPGEssawy 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 --FVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASlttgmasqasetlqvprtprpgvesadsrrlaTKHSRKALK 265
Cdd:cd15971 162 tgFIIYTFILGFFVPLTIICLCYLFIIIKVKSSGIRVGS--------------------------------SKRKKSEKK 209
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  266 ASLTLGILLGMFFVTWLPFFVANiVQAVCDCISP-----GLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15971 210 VTRMVSIVVAVFVFCWLPFYIFN-VSSVSVSISPtpglkGMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
33-331 1.00e-15

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 76.74  E-value: 1.00e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMppamLNALYGRWVLARGLCLLWTAFDVMCCSA 112
Cdd:cd15100   7 LCVSGTLIACENAIVVAIIFSTPSLRAPMFLLIGSLALADLLAGLGLI----LHFVFRYCVYSEALSLVSVGLLVAAFSA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  113 SILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWHELGHArppvpGQCRLLASLPFVLVA 192
Cdd:cd15100  83 SVCSLLAITVDRYLSLYNALTYYSERTLTFTYVMLALLWTLALGLGLLP-VLGWNCLREG-----SSCSVVRPLTKNHLA 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  193 S-GLTFFLPSGAICFTYCRILLAARKQAVQVAslttgmasqasetLQvprtprpgvesadSRRLATKHSRKALKASLTLG 271
Cdd:cd15100 157 VlAVAFLLVFALMLQLYAQICRIVLRHAHQIA-------------LQ-------------RHFLAPSHYVATRKGVSTLA 210
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  272 ILLGMFFVTWLPFFVANIVQavcDCISPGLFDVLTWL-GYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15100 211 LILGTFAACWIPFAVYCLLG---DGSSPALYTYATLLpATYNSMINPIIYAFRNQDIQKVL 268
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
34-329 1.17e-15

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 76.95  E-value: 1.17e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   34 CVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSAS 113
Cdd:cd14970   8 SVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELF-LLGLPFLATSYLLGYWPFGEVMCKIVLSVDAYNMFTS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  114 ILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAAL--------ASFLPLLLGWHELGhARPPVPGQCRLLAS 185
Cdd:cd14970  87 IFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVlglpviifARTLQEEGGTISCN-LQWPDPPDYWGRVF 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 LPFVLVasgLTFFLPSGAICFTYCRILLAARkqavqvaslttgmasqasetLQVPRTPRPGVESADSRRLATKhsrkalk 265
Cdd:cd14970 166 TIYTFV---LGFAVPLLVITVCYSLIIRRLR--------------------SSRNLSTSGAREKRRARRKVTR------- 215
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  266 aslTLGILLGMFFVTWLPFFVANIVQAVcdcISP-------GLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd14970 216 ---LVLVVVAVFVVCWLPFHVFQIVRLL---IDPpetltvvGVFLFCIALSYANSCLNPILYAFLDENFRK 280
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
35-329 1.91e-15

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 76.35  E-value: 1.91e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYgRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15093   9 VVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNALR-HWPFGSVLCRLVLSVDGINMFTSI 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWsLAALASFLPLLLgwhelgHARPPVPGQ----CRLLASLP--- 187
Cdd:cd15093  88 FCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVW-VASLLVILPVVV------FAGTRENQDgssaCNMQWPEPaaa 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 ----FVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASlttgmasqasetlqvprtprpgvesadSRRlatKHSRKa 263
Cdd:cd15093 161 wsagFIIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLRAGW---------------------------QQR---KRSER- 209
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  264 lKASLTLGILLGMFFVTWLPFFVANIVQAVC----DCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15093 210 -KVTRMVVMVVVVFVICWLPFYVLQLVNVFVqlpeTPALVGVYHFVVILSYANSCANPILYGFLSDNFKK 278
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
32-329 2.44e-15

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 76.36  E-value: 2.44e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   32 ALCVVI-ALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCC 110
Cdd:cd15205   5 ITYVLIfVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQSTAV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  111 SASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALasFLPLLLGWHELGHARPPVPGQ----CRLLASL 186
Cdd:cd15205  85 VTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVI--VGSPMLFVQQLEVKYDFLYEKrhvcCLERWYS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  187 P--------FVLVasgLTFFLPSGAICFTYCRIL--LAARKQAVQVASLTTgmasqasetlqvprtpRPGVESADSrrla 256
Cdd:cd15205 163 PtqqkiyttFILV---ILFLLPLTTMLFLYSRIGyeLWIKKRVGDASVLQT----------------IHGIEMSKI---- 219
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  257 tkhSRKALKASLTLGILLGMFFVTWLPFFV-------ANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15205 220 ---SRKKKRAVKMMVTVVLLFAVCWAPFHVvhmmieySNLENKYDGVTIKLIFAIVQLIGFSNSFNNPIVYAFMNENFKK 296
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
34-331 2.83e-15

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 75.92  E-value: 2.83e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   34 CVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSAS 113
Cdd:cd14977   8 LVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQVTSLGVT 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  114 ILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLLGWHELGHARP--PVPGQCRLLASLPFVLV 191
Cdd:cd14977  88 VFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLA-VPEAVLSTVARESSLdnSSLTVCIMKPSTPFAET 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  192 AS--------GLTFFLPSGAICFTYCrilLAARKQavqvaslttgmasqasetlqvpRTPRPGVESADSRRLATKHsrka 263
Cdd:cd14977 167 YPkarswwlfGCYFCLPLAFTAVCYL---LMARTL----------------------IRAAKEYTRGTKKHMKQRR---- 217
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  264 lKASLTLGILLGMFFVTWLPFFVANIVQAVCDC---ISPGLF-DVLTW----LGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd14977 218 -QLAKTVLCLVLVFAFCWLPEHISNILRATLYNevlIDTRSTlDILDLigqfLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
32-331 2.96e-15

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 75.99  E-value: 2.96e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   32 ALCVVIALTAAANSLL-IALICTQPALRNTSNFFLVSLFTSDLMVGLVVmpPAMLNAL--YGRWVLARGLCLLWTAFDVM 108
Cdd:cd15928   5 AVCSVLMLVGASGNLLtVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVL--PLDLYRLwrYRPWRFGDLLCRLMYFFSET 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAAL-ASFLPLLLGWHELGHARPPVPGQCRLLAS-- 185
Cdd:cd15928  83 CTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVsAGPALVLVGVEHIQGQQTPRGFECTVVNVss 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 --LPFVLVASGLTFFLPSGAICFTYCrilLAARKqavqvaslttgmasqasetlqVPRTPRPGVESADSRRlaTKHSRKA 263
Cdd:cd15928 163 glLSVMLWVSTSFFFVPMVCLSLLYG---LIGRA---------------------LWDRRQRSRTAGASRR--DNNHRQT 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  264 LKaslTLGILLGMFFVTWLPFFVANI--------------VQAVCDCISPGLFdvltwlgYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15928 217 VR---MLAVIVLAFVLCWLPFHVGRVifnhsrastkhlhyVSQYFNLVSFVLF-------YLSAAINPILYNLMSKRYRY 286

                ..
gi 4504545  330 AL 331
Cdd:cd15928 287 AV 288
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
31-331 6.28e-15

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 74.92  E-value: 6.28e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCC 110
Cdd:cd15980   5 ASYLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGISV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  111 SASILNLCLISLDRYLLILSPLRYKLrmTPLRALALVLGAWSLA-ALASFLPLLLGWHELGHARPPVPGQCRllaSLPFV 189
Cdd:cd15980  85 SASVFTLVAIAVDRFRCIVYPFKQKL--TISTAVVIIVIIWVLAiAIMCPSAVMLHVQEEKNYRVVLGSQNK---TSPVY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  190 LVASGltffLPSGAICFTYCRILLAARKQAvqVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLT 269
Cdd:cd15980 160 WCRED----WPNQEMRKIYTTVLFANIYLA--PLSLIVIMYARIGITLFKTAMPHTGKHNQEQRHVVSRKKQKVIKMLLI 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  270 LGILlgmFFVTWLPFFV-------ANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15980 234 VALL---FILSWLPLWTlmmlsdyANLSPNQLQIINIYIYPFAHWLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
31-331 7.50e-15

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 75.19  E-value: 7.50e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGR-WVLARGLCLLWTAFDVMC 109
Cdd:cd15005   5 TTLGLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSgWIYGALSCKVIAFLAVLF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  110 CSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLL-LGWHELGHARPPVPGQCRLLAS--- 185
Cdd:cd15005  85 CFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFdVGTYTFIREEDQCTFEHRSYKAndt 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 LPFVLVASGLTFflpsgAICFTYCRILLAAR-----KQAVQVASLT----------TGMASQASET--LQVPRTP----- 243
Cdd:cd15005 165 LGFMLVLAVVIA-----ATHLVYLKLLIFLRhhrkmKPAQLVPAISqnwtfhgpgaTGQAAANWTAgfGRGPTPPtllgi 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  244 RPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQA-VCDCISPGLF-DVLTWLGYCNSTMNPIIYP 321
Cdd:cd15005 240 RQAFHSGARRLLVLDEFKMEKRLTRMFYAITLLFLLLWSPYIVACYIRVfVRGYAVPQGFlTAAVWMTFAQAGVNPIVCF 319
                       330
                ....*....|
gi 4504545  322 LFMRDFKRAL 331
Cdd:cd15005 320 FFNRELRKCL 329
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
29-320 8.21e-15

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 74.64  E-value: 8.21e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15390   3 WSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAIT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYklRMTPLRALALVLGAWSLAALASFlPLLL--GWHELGHARPPVPGQCRL---- 182
Cdd:cd15390  83 TVAASVFTLMAISIDRYIAIVHPLRP--RLSRRTTKIAIAVIWLASFLLAL-PQLLysTTETYYYYTGSERTVCFIawpd 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  183 ----LASLPFVLVASGLTFFLPSGAICFTYCRILLAARkqavqvASLTTGMASQASEtlqvprtprpgvesadsRRLATK 258
Cdd:cd15390 160 gpnsLQDFVYNIVLFVVTYFLPLIIMAVAYTRVGVELW------GSKTIGENTPRQL-----------------ESVRAK 216
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  259 hsRKALKaslTLGILLGMFFVTWLP----FFVANIVQAVCDciSPGLFDV---LTWLGYCNSTMNPIIY 320
Cdd:cd15390 217 --RKVVK---MMIVVVVIFAICWLPyhlyFILTYLYPDINS--WKYIQQIylaIYWLAMSNSMYNPIIY 278
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
35-331 1.33e-14

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 74.21  E-value: 1.33e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIaLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLarGLCLLWTAFDV------- 107
Cdd:cd14978   9 VICIFGIIGNILNL-VVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSS--FLSYFYAYFLPyiyplan 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLLGWH-----ELGHARPPVPGQCRL 182
Cdd:cd14978  86 TFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLN-LPRFFEYEvveceNCNNNSYYYVIPTLL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  183 LASLPFVLVA-----SGLTFFLPSGAICFTYCRILLAARKQAvqvaslttgmasqasetlqvprtpRPGVESADSRRLAT 257
Cdd:cd14978 165 RQNETYLLKYyfwlyAIFVVLLPFILLLILNILLIRALRKSK------------------------KRRRLLRRRRRLLS 220
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  258 KHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLF-----DVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd14978 221 RSQRRERRTTIMLIAVVIVFLICNLPAGILNILEAIFGESFLSPIyqllgDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
33-320 1.41e-14

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 73.62  E-value: 1.41e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSA 112
Cdd:cd14964   5 LSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGANLA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  113 SILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLlgWHELGHARPPVPGQCRLLASLPFVLVA 192
Cdd:cd14964  85 SIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLV--GKGAIPRYNTLTGSCYLICTTIYLTWG 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  193 SGLT-FFLPSGAICFTYCRILLAARKQavqvaslttgmasqasetlqvprtprpgveSADSRRLATKHSRKALKASLTLG 271
Cdd:cd14964 163 FLLVsFLLPLVAFLVIFSRIVLRLRRR------------------------------VRAIRSAASLNTDKNLKATKSLL 212
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 4504545  272 ILLGMFFVTWLPFFVANIVQAV--CDCISPGLFDVLTWLGYCNSTMNPIIY 320
Cdd:cd14964 213 ILVITFLLCWLPFSIVFILHALvaAGQGLNLLSILANLLAVLASTLNPFIY 263
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
30-331 2.58e-14

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 72.66  E-value: 2.58e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   30 AAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMC 109
Cdd:cd15214   3 SIAIIIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  110 CSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWsLAALASFLPLLLGWHELGHARPP---VPGQCRLLASL 186
Cdd:cd15214  83 SSASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIW-LHSLIGCLPPLFGWSSLEFDRFKwmcVAAWHKEAGYT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  187 PFVLVASGLtffLPSGAICFTYCRILLAARkqavqvaslttgmASQAsetlqvprtprpgvesadsrrlatkhsrkalKA 266
Cdd:cd15214 162 AFWQVWCAL---LPFVVMLVCYGFIFRVAR-------------ANQC-------------------------------KA 194
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  267 SLTLGILLGMFFVTWLPFFVANIVQAVC--DCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15214 195 FITILVVLGAFVTTWGPYMVVISTEALWgkNSVSPQLETLATWLSFTSAVCHPLIYGLWNKTVRKEL 261
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
29-331 2.68e-14

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 72.97  E-value: 2.68e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNA------LYGRWVlarglCLLW 102
Cdd:cd15357   3 MSLVYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEVYEMwsnypfLFGPVG-----CYFK 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  103 TAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPlLLGWHELGHARPP----VPG 178
Cdd:cd15357  78 TALFETVCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFS-IP-NTSIHGIKLQYFPngtlIPD 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  179 Q--CRLLASL----PFVLVASGLTFFLPSGAICFTYCRILLAARKQavqvaslTTGMASQASETLQVPrtprpgvesadS 252
Cdd:cd15357 156 SatCTVVKPLwiynLIIQITSLLFYVLPMGVISVLYYLMGLKLRGD-------KSLEADEMNVNIQRP-----------S 217
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  253 RRLATKhsrkalkaslTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTW-------LGYCNSTMNPIIYPLFMR 325
Cdd:cd15357 218 RKSVTK----------MLFVLVLVFAICWAPFHVDRLFFSFVVEWTEPLANVFNLihvvsgvFFYLSSAVNPIIYNLLSR 287

                ....*.
gi 4504545  326 DFKRAL 331
Cdd:cd15357 288 RFRTAF 293
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
32-320 3.80e-14

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 72.46  E-value: 3.80e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   32 ALCVVIALTAaaNSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGR-WVLARGLCLLWTAFDVMCC 110
Cdd:cd15394   8 SLVVLVGVVG--NYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRgWVFGRFMCYFVFLMQPVTV 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  111 SASILNLCLISLDRYLLILSPLRYklRMTPLRALALVLGAWSLAALASfLPLLLGWHELgharpPVPGQ----C------ 180
Cdd:cd15394  86 YVSVFTLTAIAVDRYYVTVYPLRR--RISRRTCAYIVAAIWLLSCGLA-LPAAAHTYYV-----EFKGLdfsiCeefwfg 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  181 ----RLLASLPFVLVasglTFFLPSGAICFTYCRILLAARKQAvqvaslttgmasqasetlqVPRTPRPGVESADSRRla 256
Cdd:cd15394 158 qekqRLAYACSTLLI----TYVLPLLAISLSYLRISVKLRNRV-------------------VPGSMTQSQAEWDRAR-- 212
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  257 tkhSRKALKaslTLGILLGMFFVTWLPFFVANIVQAV-CDCISPGLFDVLT----WLGYCNSTMNPIIY 320
Cdd:cd15394 213 ---RRKTFR---LLVVVVVAFAICWLPLHIFNVIRDIdIDLIDKQYFNLIQllchWLAMSSACYNPFLY 275
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
33-214 5.18e-14

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 71.87  E-value: 5.18e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSA 112
Cdd:cd15431   7 LLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGIT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  113 SILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLL------GWHELGHARPPVPGQCRLL--- 183
Cdd:cd15431  87 ECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLTmplhfcGPNVINHFFCEVQALLKLAcsd 166
                       170       180       190
                ....*....|....*....|....*....|...
gi 4504545  184 --ASLPFVLVASGLTFFLPSGAICFTYCRILLA 214
Cdd:cd15431 167 tsLNEILMFATSIFTLLLPFSFILVSYIRIGVA 199
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
51-331 5.47e-14

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 72.36  E-value: 5.47e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   51 ICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGR-WVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLIL 129
Cdd:cd15134  25 IARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQYpWVFGEVFCKLRAFLSEMSSYASVLTITAFSVERYLAIC 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  130 SPLRYKLRMTPLRALALVLGAWSLAALASF-LPLLLGWHELGHarPPVPG-------QCRLLASLPF---VLVASGLTFF 198
Cdd:cd15134 105 HPLRSHTMSKLSRAIRIIIAIWIIAFVCALpFAIQTRIVYLEY--PPTSGealeesaFCAMLNEIPPitpVFQLSTFLFF 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  199 L-PSGAICFTYCRIllaarkqAVQVASLTTGmasqasetlqvprtpRPGVESADSRRLATKHSRKALKASLTLGIllgMF 277
Cdd:cd15134 183 IiPMIAIIVLYVLI-------GLQLRRSTLL---------------RRGQRSVSGGRRSSQSRRTVLRMLVAVVV---AF 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  278 FVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYC-------NSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15134 238 FICWAPFHAQRLLTVYAKNMTPPYLFINRILFYIsgvlyyvSSTVNPILYNVMSAKYRQAF 298
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
29-331 1.04e-13

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 71.31  E-value: 1.04e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15073   3 VAAYLIVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKlRMTPLRALALVLGAWSLAALASFLPlLLGWHElgHARPPVPGQC-------- 180
Cdd:cd15073  83 FGMASIGLLTVVAVDRYLTICRPDLGR-KMTTNTYTVMILLAWTNAFFWAAMP-LVGWAS--YALDPTGATCtinwrknd 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  181 RLLASlpFVLVASGLTFFLPSGAICFTYCRILLAARKQAvqvaslttgmASQASETLQVPRTprpgvesadsrrlatkHS 260
Cdd:cd15073 159 SSFVS--YTMSVIVVNFIVPLAVMFYCYYNVSRFVKKVL----------ASDCLESVNIDWT----------------DQ 210
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504545  261 RKALKASLtlgILLGMFFVTWLPFFVANIVQAVCDCIS-PGLFDVLTWLGYCNSTM-NPIIYPLFMRDFKRAL 331
Cdd:cd15073 211 NDVTKMSV---IMIVMFLVAWSPYSIVCLWASFGEPKKiPPWMAIIPPLFAKSSTFyNPCIYVIANKKFRRAI 280
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
33-218 2.39e-13

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 69.87  E-value: 2.39e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSA 112
Cdd:cd15215   6 IVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  113 SILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLLGWHELGHARPPVPGQCRLLASLPFVLVA 192
Cdd:cd15215  86 GVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQS-TPPLYGWGQAAFDERNALCSVIWGSSYSYTILS 164
                       170       180
                ....*....|....*....|....*.
gi 4504545  193 SGLTFFLPSGAICFTYCRILLAARKQ 218
Cdd:cd15215 165 VVSSFVLPVIIMLACYSMVFRAARRC 190
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
32-331 3.03e-13

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 69.54  E-value: 3.03e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   32 ALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGL-VVMPPAMLNALYGRWVLARGLCLLWTAFdvmcc 110
Cdd:cd15960   6 ALCVTGTVMACENAIVIAILFYTPSLRAPMFILIGSLALADLLAGLgLIANFVAIYVMNSEAVTLCSAGLLLAAF----- 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  111 SASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWHELGHarppvPGQCRLLASL---- 186
Cdd:cd15960  81 SASVCSLLAITVDRYLSLYNALTYHTERTLTFTYGLLALLWLTCIGIGLLP-AMGWNCLRA-----PASCSVLRPVtknn 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  187 PFVLVASGLTFFLPSGAICFTYCRILLAARKQ-AVQVASLTTGMASqasetlqvprTPRPGVEsadsrrlatkhsrkalk 265
Cdd:cd15960 155 AAVLAVSFLLLFALMMQLYLQICRIAFRHAQQiAVQHQFVNFCLAS----------STRKGVS----------------- 207
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  266 aslTLGILLGMFFVTWLPFFVANIvqaVCDCISPGLFDVLTWL-GYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15960 208 ---TLSLILATFAFCWVPFAVYSM---VADSSYPMIYTYYLVLpAACNSVINPIIYAFRNPDIQKSL 268
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
29-320 3.71e-13

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 69.55  E-value: 3.71e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYGrWVLARGLCLLWTAFDVM 108
Cdd:cd14984   3 LPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLF-VLTLPFWAVYAADG-WVFGSFLCKLVSALYTI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLL---GWHELGHAR--PPVPGQCRLL 183
Cdd:cd14984  81 NFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLS-LPEFIfsqVSEENGSSIcsYDYPEDTATT 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  184 ASLPFVLVASGLTFFLPSGAICFTYCRILlaarkqavqvaslttgmasqasETLqvprtprpgvesadsRRLATKHSRKA 263
Cdd:cd14984 160 WKTLLRLLQNILGFLLPLLVMLFCYSRII----------------------RTL---------------LRARNHKKHRA 202
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504545  264 LKASLTLGILlgmFFVTWLPFFVANIVQAVCD-------CISPGLFDV-LTW---LGYCNSTMNPIIY 320
Cdd:cd14984 203 LRVIFAVVVV---FFLCWLPYNIVLLLDTLQLlgiisrsCELSKSLDYaLQVtesLAFSHCCLNPVLY 267
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
31-323 4.43e-13

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 69.38  E-value: 4.43e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCC 110
Cdd:cd15197   5 ATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVIRYLQVVVT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  111 SASILNLCLISLDRYLLILSPLRYKlrMTPLRALALVLGAWSLAALASF-LPLLLGWHELGHARPpvpgQCRLL-----A 184
Cdd:cd15197  85 YASTYVLVALSIDRYDAICHPMNFS--QSGRQARVLICVAWILSALFSIpMLIIFEKTGLSNGEV----QCWILwpepwY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  185 SLPFVLVASGLTFFLPsgAICFTYCRILLAarkqavqvasLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKAL 264
Cdd:cd15197 159 WKVYMTIVAFLVFFIP--ATIISICYIIIV----------RTIWKKSKIQVTINKAGLHDGSSRRSSSRGIIPRAKIKTI 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  265 KASLtlgILLGMFFVTWLPFFVANIVQAVCDC--------ISPglfdVLTWLGYCNSTMNPIIYPLF 323
Cdd:cd15197 227 KMTF---VIVTVFIICWSPYFVFDLLDVFGLLprsktkiaAAT----FIQSLAPLNSAINPLIYCLF 286
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
34-320 5.06e-13

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 69.22  E-value: 5.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   34 CVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVmpPAML--NALYGRWVLARGLCLLWTAFDVMCCS 111
Cdd:cd14982   8 SLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTL--PFRIyyYLNGGWWPFGDFLCRLTGLLFYINMY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  112 ASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLLGwhelghaRPPVPGQCR---------- 181
Cdd:cd14982  86 GSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVAS-VPLLLL-------RSTIAKENNsttcfeflse 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  182 -LLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQvaslttgmasqasetlqvprtprpgvesadsrrlATKHS 260
Cdd:cd14982 158 wLASAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQ----------------------------------SQKSV 203
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  261 RKAlKASLTLGILLGMFFVTWLPFFVANIV------QAVCDCISPGLFD----VLTWLGYCNSTMNPIIY 320
Cdd:cd14982 204 RKR-KALRMILIVLAVFLVCFLPYHVTRILyllvrlSFIADCSARNSLYkayrITLCLASLNSCLDPLIY 272
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
39-164 5.46e-13

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 68.79  E-value: 5.46e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLC 118
Cdd:cd15235  14 LTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSFLLA 93
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLL 164
Cdd:cd15235  94 VMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLL 139
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
29-331 6.58e-13

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 69.07  E-value: 6.58e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15395   3 LALAYSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQCI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYklRMTPLRALALVLGAWSLAALASfLPLLLgWHELGHA---RPPV--------- 176
Cdd:cd15395  83 SITVSIFSLVLIAIERHQLIINPRGW--RPNNRHAYVGIAVIWVLAVLTS-LPFLI-FQVLTDEpfkNVNVsldaykgky 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  177 ------PGQCRLLASLPFVLVasgLTFFLPSGAICFTYCRILLAARKQavqvasltTGMASQASETlqvprtprpGVESA 250
Cdd:cd15395 159 vcldqfPSDTIRLSYTTCLLV---LQYFGPLCFIFICYLKIYIRLKRR--------NNMMDKMRDN---------KYRSS 218
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  251 DSRRLATkhsrkalkasLTLGILLGmFFVTWLPFFVANIV-----QAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMR 325
Cdd:cd15395 219 ETKRINI----------MLISIVVA-FAVCWLPLNIFNAVfdwnhEAIATCNHNLLFLICHLTAMISTCVNPIFYGFLNK 287

                ....*.
gi 4504545  326 DFKRAL 331
Cdd:cd15395 288 NFQRDL 293
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
28-331 1.18e-12

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 68.13  E-value: 1.18e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLwTAFDV 107
Cdd:cd15389   2 LLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHL-SRFAQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 MCCS-ASILNLCLISLDRYLLILSPLryKLRMTPLRALALVLGAWSLAALASfLPLLL----------GWHELGHARPPV 176
Cdd:cd15389  81 YCSVyVSTLTLTAIALDRHRVILHPL--KPRITPCQGVVVIAIIWIMASCLS-LPHAIyqklvefeysNERTRSRCLPSF 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  177 PGQCRL----LASLPFVLVasgltFFLPSGAICFTYCRIllaARKQAVQVASlttgmasqasetlqvprtprpGVESADS 252
Cdd:cd15389 158 PEPSDLfwkyLDLATFILQ-----YVLPLLIIGVAYTRV---AKKLWLRNAI---------------------GDVTTEQ 208
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  253 RRLATKHSRKALKAsLTLGILLgmFFVTWLPFFVANIVQAVCDcISP--GLFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15389 209 YVAQRRKKKKTIKM-LMLVVLL--FAICWLPLNCYHVLLSSHP-IRSnsALFFAFHWLAMSSTCYNPFIYCWLNDSFRSE 284

                .
gi 4504545  331 L 331
Cdd:cd15389 285 L 285
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
44-331 1.21e-12

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 67.90  E-value: 1.21e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLV-VMPPAMLNALYGRWVLARGLCL--LWTAFDVMCCS---ASILNL 117
Cdd:cd15103  18 NILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSnALETIVIILLNNGYLVPRDSFEqhIDNVIDSMICSsllASICSL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  118 CLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHElgharppvpgqcrllaslpFVLVASGLTF 197
Cdd:cd15103  98 LAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFIIYSDSV-------------------PVIICLISMF 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  198 FLPSGAICFTYCRILLAARKQAVQVASLttgmasqasetlqvprtprPGVESAdsrrlatkHSRKALKASLTLGILLGMF 277
Cdd:cd15103 159 FAMLVLMASLYVHMFLLARSHVKKIAAL-------------------PGQRST--------RQRANMKGAVTLTILLGVF 211
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  278 FVTWLPFFVANIV------QAVCDCISpGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15103 212 IFCWAPFFLHLTLmiscpsNPYCACYM-SHFNVYLILIMCNSVIDPLIYAFRSQELRKTF 270
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
35-330 2.52e-12

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 67.13  E-value: 2.52e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSD--LMVGLVVMppAMLNALyGRWVLARGLCLLWTAFDVMCCSA 112
Cdd:cd15974   9 LVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADelFMLGLPFL--ATQNAI-SYWPFGSFLCRLVMTVDGVNQFT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  113 SILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLL------GWHELGHARPpvpgQCRLLASL 186
Cdd:cd15974  86 SIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVV-LPVIIfsdvqpDLNTCNISWP----EPVSVWST 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  187 PFVLVASGLTFFLPSGAICFTYCRILLAarkqavqvaslttgmasqasetlqvprtprpgVESADSRRLATKHSRKALKA 266
Cdd:cd15974 161 AFIIYTAVLGFFGPLLVICLCYLLIVIK--------------------------------VKSSGLRVGSTKRRKSERKV 208
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504545  267 SLTLGILLGMFFVTWLPFFVANIVQAVC----DCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15974 209 TRMVVIIVVVFVFCWLPFYMLNIVNLIVilpeEPAFVGVYFFVVVLSYANSCANPILYGFLSDNFKQS 276
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
31-331 2.82e-12

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 66.78  E-value: 2.82e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIA-LTAAANSLLIALICTQPALR-NTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRwVLARGLCLLWTAFDVM 108
Cdd:cd15099   4 AVLCFLAGpVTFLENILVLLTILSSTALRrRPSYLFIGSLALADMLASVIFTISFLDFHVFHQ-RDSRNLFLFKLGGVTM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWHELGHARPPvpgqCRLLASLP- 187
Cdd:cd15099  83 AFTASVGSLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISFLP-LMGWRCKTWDSPC----SRLFPYIDr 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 -FVLVASGLTFFLPSGaICFTYCRILLAARKQAVQVASLTTGmasqaseTLQVPRTPRpgvesadsrrlatkhSRKALKA 266
Cdd:cd15099 158 hYLASWTGLQLVLLFL-IIYAYPYILWKAHRHEANMGGPKLG-------RQQVKGQAR---------------MRMDIRL 214
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504545  267 SLTLGILLGMFFVTWLP---FFVANIVQAVCDCISPgLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15099 215 AKTLSLILLVLAICWLPvlaFMLVDVRVTLTNKQKR-MFAFCSMLCLVNSCVNPIIYALRSRELRGAM 281
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
29-320 3.74e-12

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 66.53  E-value: 3.74e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMlnalygRWVLARGlcLLWTAFDVM 108
Cdd:cd15204   3 LGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEM------DYYVVRQ--RSWTHGDVL 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILN----------LCLISLDRYLLILSPLRykLRMTPLRALALVLGAWSLAALASfLPLLLGWHELGHARP---- 174
Cdd:cd15204  75 CAVVNYLRtvslyvstnaLLVIAIDRYLVIVHPLK--PRMKRRTACVVIALVWVVSLLLA-IPSAVYSKTTPYANQgkif 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  175 -----PVPGQCRLLASLPFVLVasgLTFFLPSGAICFTYCRILlaarkqavqvaslttgmasqasetLQVPRTPRPGVES 249
Cdd:cd15204 152 cgqiwPVDQQAYYKAYYLFLFV---LEFVLPVLIMTLCYLRIV------------------------RKVWFRRVPGQQT 204
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  250 ADSRRLAtkhsRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG------LFDVLTWLGYCNSTMNPIIY 320
Cdd:cd15204 205 EQIRRRL----RRRRRKVRLLVVILTAFVLCWAPYYGYAIVRDFFPTLLSKeklnttIFYIVEALAMSNSMINTVVY 277
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
34-331 3.79e-12

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 66.43  E-value: 3.79e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   34 CVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSAS 113
Cdd:cd15978   8 SLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSVS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  114 ILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLA-ALASFLPLLLGWHELGHARPPVPGQCRLLaslpfvlva 192
Cdd:cd15978  88 TFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSfTIMLPYPIYSNLVPFTRINNSTGNMCRLL--------- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  193 sgltffLPSGAICFTYCRILLAarkqavqVASLTTGMASQASETLQVPRTPRpGVESADSRRLATKhsrkalkaslTLGI 272
Cdd:cd15978 159 ------WPNDVTQQSWYIFLLL-------ILFLIPGIVMMTAYGLISLELYR-GIKFLMAKKRVIR----------MLIV 214
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  273 LLGMFFVTWLPFFVANIVQAVcDCISPGL------FDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15978 215 IVILFFLCWTPIFSANAWRAF-DTRSADRllsgapISFIHLLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
32-328 6.20e-12

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 65.72  E-value: 6.20e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   32 ALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCS 111
Cdd:cd16003   6 AYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSVF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  112 ASILNLCLISLDRYLLILSPLRYKLRMTplrALALVLGA-WSLAALASFlplllgwhelgharppvpGQCrlLASLPFVL 190
Cdd:cd16003  86 ASIYSMTAIAVDRYMAIIDPLKPRLSAT---ATKVVIGSiWILAFLLAF------------------PQC--LYSKTKVM 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  191 VASGLTFFL-PSGA----------ICFTYCRILLaarkqAVQVASLTTGMASQASETlqvprtprPGvESADSRRLATKH 259
Cdd:cd16003 143 PGRTLCFVAwPGGPdqhftyhiivIVLVYCLPLL-----VMGITYTIVGITLWGGEI--------PG-DTSDKYHEQLRA 208
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504545  260 SRKALKASLtlgILLGMFFVTWLPFFVANIVQAVCDCIS-----PGLFDVLTWLGYCNSTMNPIIYPLFMRDFK 328
Cdd:cd16003 209 KRKVVKMMI---IVVLTFAICWLPYHIYFIVTGLYQQLNrwkyiQQVYLASFWLAMSSTMYNPIIYCCLNKRFR 279
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
29-329 6.37e-12

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 65.95  E-value: 6.37e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15209   3 LACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGharpPVPGQCRL--LASL 186
Cdd:cd15209  83 SVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPNFFIGSLQYD----PRIYSCTFaqTVST 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  187 PFVLVASGLTFFLPSGAICFTYCRI---LLAARKQAVQVAslttgmasqasetlqvprtpRPGVESADSRRLatkhsrka 263
Cdd:cd15209 159 VYTITVVVIHFLLPLLIVSFCYLRIwvlVLQVRQRVKPDQ--------------------RPKLKPADVRNF-------- 210
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  264 lkasLTLGILLGMFFVTWLPF-----FVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15209 211 ----LTMFVVFVLFAVCWAPLnfiglAVAINPKEMAPKIPEWLFVASYFMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
29-330 6.52e-12

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 65.97  E-value: 6.52e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVmpPAMLNAL--YGRWVLARGLCLLWTAFD 106
Cdd:cd15132   3 VTIVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCL--PFDLYRLwkSRPWIFGEFLCRLYHYIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  107 VMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALAS--FLPLLLGWHELGHARPPVPGQCRL-- 182
Cdd:cd15132  81 EGCTYATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAgpFLFLVGVEQDNNIHPDDFSRECKHtp 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  183 ----LASLPFVLVASGLTFFLPSGAICFTYCRIllaARKqavqvaslttgmasqasetLQVPRTPRPGVESADSRRlatk 258
Cdd:cd15132 161 yavsSGLLGIMIWVTTTYFFLPMLCLSFLYGFI---GRK-------------------LWKSKNDLRGPNAAARER---- 214
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  259 HSRKALKaslTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFD-----VLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15132 215 SHRQTVR---ILAVVVLAFIICWLPFHIGRILFANTEDYRTMMFSqyfniVAMQLFYLSASINPILYNLISRKYRAA 288
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
32-330 6.92e-12

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 65.68  E-value: 6.92e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   32 ALCVVIALTAAANSLLIALICTQ-PALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNAL-YGRWVLARGLCLLWTAFDVMC 109
Cdd:cd15131   5 VTCVLLFVVGVTGNLMTMLVVSKyRDMRTTTNLYLSSMAFSDLLI-FLCMPLDLYRLWqYRPWNFGDLLCKLFQFVSESC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  110 CSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAAL-ASFLPLLLGWHELGHARPPVPGQCR------- 181
Cdd:cd15131  84 TYSTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLsAGPIFVLVGVEHENGTNPIDTNECKateyavr 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  182 --LLASLPFVlvaSGLTFFLPsgAICFTYCRILLAARKQAvqvaslttgmasqasetlqvprtpRPGVESADSRRLATKH 259
Cdd:cd15131 164 sgLLTIMVWV---SSVFFFLP--VFCLTVLYSLIGRKLWR------------------------RRRENIGPNASHRDKN 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  260 SRKALKaslTLGILLGMFFVTWLPFFVAN---------------IVQAVCDCISPGLFdvltwlgYCNSTMNPIIYPLFM 324
Cdd:cd15131 215 NRQTVK---MLAVVVFAFVLCWLPFHVGRylfsksfeagsleiaLISQYCNLVSFVLF-------YLSAAINPILYNIMS 284

                ....*.
gi 4504545  325 RDFKRA 330
Cdd:cd15131 285 KKYRVA 290
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
29-159 7.17e-12

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 65.54  E-value: 7.17e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15012   2 FIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSL 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASF 159
Cdd:cd15012  82 SYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNT 132
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
44-331 9.08e-12

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 65.17  E-value: 9.08e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLmVGLVVMP-PAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISL 122
Cdd:cd15088  18 NGIVLYVLVRCSKLRTAPDIFIFNLAVADL-LFMLGMPfLIHQFAIDGQWYFGEVMCKIITALDANNQFTSTYILTAMSV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  123 DRYLLILSPLRYKLRMTPLRALALVLGAWslaaLASFLPLLLGWheLGHARPPVPGQCRLLA-SLP-------FVLVASG 194
Cdd:cd15088  97 DRYLAVVHPIRSTKYRTRFVAKLVNVGLW----AASFLSILPVW--VYSSLIYFPDGTTFCYvSLPspddlywFTIYHFI 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  195 LTFFLPSGAICFTYCRILlaarkqavqvASLTTGMAsqasetlqvPRTPRPgvesadsrrlatkHSRKALKASLTLGILL 274
Cdd:cd15088 171 LGFAVPLVVITVCYILIL----------HRLARGVA---------PGNQSH-------------GSSRTKRVTKMVILIV 218
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4504545  275 GMFFVTWLPFFVANIVQAVCDciSPGLFDVLTW-----LGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15088 219 VVFIVCWLPFHVVQLVNLAMN--RPTLAFEVAYflsicLGYANSCLNPFVYILVSENFRKRL 278
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
31-331 1.27e-11

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 64.56  E-value: 1.27e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCC 110
Cdd:cd15196   5 AVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVLPQLIWDITYRFYGGDLLCRLVKYLQVVGM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  111 SASILNLCLISLDRYLLILSPLRYkLRMTPLRALALVLGAWSLAALASfLPLLLGWHElgHARPPVPGQCRLLASLPFVL 190
Cdd:cd15196  85 YASSYVLVATAIDRYIAICHPLSS-HRWTSRRVHLMVAIAWVLSLLLS-IPQLFIFSY--QEVGSGVYDCWATFEPPWGL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  191 VA-----SGLTFFLPSGAICFTY---CRILLAARKQAVQvaslttgmasqasetlqvprtprpgvesadsrrlatkhsrk 262
Cdd:cd15196 161 RAyitwfTVAVFVVPLIILAFCYgriCYVVWRAKIKTVK----------------------------------------- 199
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  263 alkasLTLGILLgMFFVTWLPFFVANIVQAVCD--CISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15196 200 -----LTLVVVA-CYIVCWTPFFVVQMWAAWDPtaPIEGPAFVIIMLLASLNSCTNPWIYLAFSGNLRRAL 264
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
31-331 1.44e-11

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 65.08  E-value: 1.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAAAN-SLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPpamLNALYgrwvlarGLCLLWTAFDVMC 109
Cdd:cd15383   5 AVTFVLFVLSACSNlAVLWSATRNRRRKLSHVRILILHLAAADLLVTFVVMP---LDAAW-------NVTVQWYAGDLAC 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  110 ----------CSASILNLCLISLDRYLLILSPL-RYKLRMtplRALALVLGAWSLAALASfLPLLLGWHeLGHARPPVP- 177
Cdd:cd15383  75 rllmflklfaMYSSAFVTVVISLDRHAAILNPLaIGSARR---RNRIMLCAAWGLSALLA-LPQLFLFH-TVTATPPVNf 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  178 GQCRLLASLP--------FVLVASGLtFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTprpgves 249
Cdd:cd15383 150 TQCATHGSFPahwqetlyNMFTFFCL-FLLPLLIMIFCYTRILLEISRRMKEKKDSAKNEVALRSSSDNIPKA------- 221
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  250 adsrRLatkhsrKALKASLtlgILLGMFFVTWLPFFVANI-----VQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFM 324
Cdd:cd15383 222 ----RM------RTLKMTI---VIVSSFIVCWTPYYLLGLwywfsPEMLEQTVPESLSHILFLFGLLNACLDPLIYGLFT 288

                ....*..
gi 4504545  325 RDFKRAL 331
Cdd:cd15383 289 ISFRRGL 295
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
36-158 2.04e-11

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 64.20  E-value: 2.04e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   36 VIALTAaaNSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASIL 115
Cdd:cd15232  12 AAALTG--NSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSELL 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 4504545  116 NLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALAS 158
Cdd:cd15232  90 LLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNS 132
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
31-330 2.24e-11

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 64.09  E-value: 2.24e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAAANSLLIALICTQ-PALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMC 109
Cdd:cd15404   4 SAVMIFILLVSFLGNFVVCLMVYQkAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMFFWLF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  110 CSASILNLCLISLDRYLLIlspLRYKLRMTPLRALALVLGAWSLAALASFlPLLLGWHEL---GHARPPVPGQCRLLASL 186
Cdd:cd15404  84 VMEGVAILLIISIDRFLII---VQKQDKLNPYRAKVLIAVSWAVSFCVAF-PLAVGSPDLqipSRAPQCVFGYTTNPGYQ 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  187 PFVLVASGLTFFLPSGAICFTYCRILLAARkqavqvaSLTTgmasqasetlqvprtprpgvesadsrrlatkhsrkalKA 266
Cdd:cd15404 160 AYVILIMLIFFFIPFMVMLYSFMGILNTVR-------SFKT-------------------------------------RA 195
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  267 SLTLGILLGMFFVTWLPFFVANIVQAVCDCI--SPGLFDVLT---WLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15404 196 FTTILILFIVFTVCWAPFTTYSLVATFNSHFyhKHNFFEISTwllWLCYLKSALNPLIYYWRIKKFRDA 264
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
44-331 2.61e-11

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 64.08  E-value: 2.61e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLD 123
Cdd:cd15008  17 NSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPGVQIYVLLSICVD 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  124 RYLLILSPLRYKLRMTplRALALVLGAWSL-AALASFLPLLLGWHELGHARPPVPGQCRLLA-SLPFVLVAsgltFFLPS 201
Cdd:cd15008  97 RFYTIVYPLSFKVSRE--KAKKMIAASWLFdAAFVSPALFFYGSNWGPHCNFFLPDSWDGAAyAIIHLLVG----FLVPS 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  202 GAICFTYCRIllaarkqavqvaslttgmasqasetlqVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTW 281
Cdd:cd15008 171 ILIILFYQKV---------------------------IKYIWRIGTDGRTVRRTMNIVPRTKVKTIKMFLMLNSMFLLSW 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 4504545  282 LPFFVANIVQAVCDCISPG--LFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15008 224 LPFYVVQLWHPRESDYRQSslVFLAVTWISFSSSASKPTLYSVYNANFRRGM 275
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
33-331 2.80e-11

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 63.89  E-value: 2.80e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMppamLNALYGRWVLARGLCLLWTAFDVMCCSA 112
Cdd:cd15961   7 LCTSGTLISCENAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGIGLI----LNFIFAYLLQSEAAKLVTVGLIVASFSA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  113 SILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWHELGHArppvpGQCRLLASLPFVLVA 192
Cdd:cd15961  83 SVCSLLAITVDRYLSLYYALTYNSERTVTFTYVMLVLLWGASICLGLLP-VMGWNCLADE-----STCSVVRPLTKNNAA 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  193 S-GLTFFLPSGAICFTYCRILLAARKQAVQVAslttgmasqasetLQvprtprpgvesadSRRLATKHSRKALKASLTLG 271
Cdd:cd15961 157 IlSVSFLLMFALMLQLYIQICKIVMRHAHQIA-------------LQ-------------HHFLATSHYVTTRKGVSTLA 210
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  272 ILLGMFFVTWLPFFVANIvqaVCDCISPGLFDVLTWL-GYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15961 211 IILGTFAACWMPFTLYSL---IADYTYPSIYTYATLLpATYNSIINPVIYAFRNQEIQKAL 268
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
29-329 4.35e-11

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 63.47  E-value: 4.35e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMvGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15090   3 IMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGNILCKIVISIDYY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAAlASFLPLLLgWHELGHARPPVpgQCRLLASLP- 187
Cdd:cd15090  82 NMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSS-AIGLPVMF-MATTKYRQGSI--DCTLTFSHPs 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 ------FVLVASGLTFFLPsgAICFTYCRILLAARKQAVQvaslttgMASQASEtlqvprtprpgvESADSRRLatkhSR 261
Cdd:cd15090 158 wywenlLKICVFIFAFIMP--VLIITVCYGLMILRLKSVR-------MLSGSKE------------KDRNLRRI----TR 212
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504545  262 KALkasltlgILLGMFFVTWLPFFVANIVQAVCDcISPGLFDVLTW-----LGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15090 213 MVL-------VVVAVFIVCWTPIHIYVIIKALVT-IPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKR 277
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
29-329 4.47e-11

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 63.38  E-value: 4.47e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15402   3 LACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGharpPVPGQCRLLASLP- 187
Cdd:cd15402  83 SVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNLFVGSLQYD----PRIYSCTFAQSVSs 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 -FVLVASGLTFFLPSGAICFTYCRILLAarkqavqvaslttgmasqaseTLQVPRTPRPgvesaDSRRLATKHSrkaLKA 266
Cdd:cd15402 159 aYTIAVVFFHFILPIIIVTFCYLRIWIL---------------------VIQVRRRVKP-----DNKPKLKPHD---FRN 209
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504545  267 SLTLGILLGMFFVTWLPF-FVANIVQAVCDCISP----GLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15402 210 FVTMFVVFVLFAVCWAPLnFIGLAVAVDPETIVPripeWLFVASYYMAYFNSCLNAIIYGLLNQNFRR 277
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
33-331 5.45e-11

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 62.98  E-value: 5.45e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGL-VVMPPAMLNALYGRWVLARGLCLLWTAFdvmccS 111
Cdd:cd15963   7 LCISGTVISCENAIVVAVIFYTPAFRAPMFLLIGSLATADLLAGLgLILHFAFVYCIQSAPVNLVTVGLLAPSF-----T 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  112 ASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWHELGHarppvPGQCRLLASLPFV-L 190
Cdd:cd15963  82 ASVSSLLAITIDRYLSLYNALTYYSERTVTRTYIMLILTWGASLCLGLLP-VVGWNCLKD-----PSTCSVVKPLTKNhL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  191 VASGLTFFLPSGAICFTYCRILLAARKQAVQVASLttgmasqasetlqvprtprpgvesadSRRLATKHSRKALKASLTL 270
Cdd:cd15963 156 VILSISFFMVFALMLQLYAQICRIVCRHAHQIALQ--------------------------RHFLPTSHYVTTRKGIATL 209
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4504545  271 GILLGMFFVTWLPFFVANIVQavcDCISPGLFDVLTWL-GYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15963 210 AVILGTFASCWLPFAVYCLLG---DYTYPALYTYATLLpATYNSMINPIIYAFRNQEIQKVL 268
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
31-329 6.41e-11

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 62.92  E-value: 6.41e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCC 110
Cdd:cd15981   5 LAYLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQGMSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  111 SASILNLCLISLDRYLLILSPLRYKLrmTPLRALALVLGAWSLAAL-----ASFLPLLLGWH-----ELGHARP------ 174
Cdd:cd15981  85 SASVFTLVAIAVERFRCIVHPFRQKL--TLRKAIVTIVIIWVLALIimcpsAVTLTVTREEHhfmvdDYNNSYPlyscwe 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  175 --PVPGQCRLLASLPFVLVasgltFFLPSGAICFTYCRIllaarkqavqvaslttgmasqASETLQVPRTPRPGVESADS 252
Cdd:cd15981 163 awPDTEMRKIYTTVLFSHI-----YLAPLTLIVIMYARI---------------------AFKLFKSSAPIRGSQGEEEE 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  253 RRLAtkhSRKALKASLTLGILLGMFFVTWLPFFV-------ANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMR 325
Cdd:cd15981 217 GRRV---SKRKIKVINMLIIVALFFTLSWLPLWTlmlltdyGHLSEDQLNLVTVYVFPFAHWLAFFNSSVNPIIYGYFNE 293

                ....
gi 4504545  326 DFKR 329
Cdd:cd15981 294 NFRR 297
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
35-331 6.42e-11

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 62.57  E-value: 6.42e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVmPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15973   9 LVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSV-PFLAASAALQHWPFGSAMCRTVLSVDGINMFTSV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWsLAALASFLPLLLgwheLGHARPPVPG--QCRLLASLP----- 187
Cdd:cd15973  88 FCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVW-ILSLLVISPIII----FADTATRKGQavACNLIWPHPawsaa 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 FVLVASGLTFFLPSGAICFtyCRILLAARKQAVqvaSLTTGMASQasetlqvprtprpgvesadsRRLATKHSRKALkas 267
Cdd:cd15973 163 FVIYTFLLGFLLPVLAIGL--CYILIIGKMRAV---ALKAGWQQR--------------------RKSEKKITRMVL--- 214
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504545  268 ltlgILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15973 215 ----MVVTVFVICWMPFYVVQLLNLFLPRLDATVNHASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
29-337 8.33e-11

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 62.57  E-value: 8.33e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15084  13 VAVLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGFMVSL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRyKLRMTPLRALALVLGAWSLAALASfLPLLLGWHELgharppVPGQCRL------ 182
Cdd:cd15084  93 TGIVGLWSLAILAFERYLVICKPMG-DFRFQQRHAVSGCAFTWGWSLLWT-SPPLFGWSSY------VPEGLRTscgpnw 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  183 ----LASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQvaslttgmaSQASETLQvprtprpgvesadsrrlatk 258
Cdd:cd15084 165 ytggTNNNSYILALFVTCFALPLSTIIFSYSNLLLTLRAVAAQ---------QKESETTQ-------------------- 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  259 hsrKALKASLTLGILLGM-FFVTWLPFFVANIVQAVCD--CISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFL 335
Cdd:cd15084 216 ---RAEKEVTRMVIAMVMaFLICWLPYATFAMVVATNKdvVIQPTLASLPSYFSKTATVYNPIIYVFMNKQFRSCLLELL 292

                ..
gi 4504545  336 PC 337
Cdd:cd15084 293 CC 294
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
35-331 9.74e-11

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 62.14  E-value: 9.74e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15979   9 VIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVSVST 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALAsFLPLLLGWH--ELGHARPPVPGQCRLLASLPFVLVA 192
Cdd:cd15979  89 FSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLI-MIPYPVYSVtvPVPVGDRPRGHQCRHAWPSAQVRQA 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  193 SG-----LTFFLPSGAICFTYCRIL------LAARKQAVQVaslttgmasqasetlqvprtprpgvesadsrrlatkhsr 261
Cdd:cd15979 168 WYvllllILFFIPGVVMIVAYGLISrelyrgLLAKKRVIRM--------------------------------------- 208
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  262 kalkasltLGILLGMFFVTWLPFFVANIVQA-----VCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15979 209 --------LVVIVAMFFLCWLPIFSANTWRAfdplsAHRALSGAPISFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
29-329 1.01e-10

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 62.18  E-value: 1.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLwTAFdVM 108
Cdd:cd15400   3 LSSVLIFTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKV-SGF-VM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCS--ASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGharpPVPGQCRLL--A 184
Cdd:cd15400  81 GLSviGSIFNITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTVVAIVPNFFVGSLEYD----PRIYSCTFVqtA 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  185 SLPFVLVASGLTFFLPSGAICFTYCRI---LLAARKQAvqvaslttgmasqASETlqvprtpRPGVESADSRRLatkhsr 261
Cdd:cd15400 157 SSSYTIAVVVIHFIVPITVVSFCYLRIwvlVIQVRRKV-------------KSES-------KPRLKPSDFRNF------ 210
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504545  262 kalkasLTLGILLGMFFVTWLPFFVANIV-----QAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15400 211 ------LTMFVVFVIFAICWAPLNLIGLAvainpQEMAPKVPEWLFVVSYFMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
31-221 1.04e-10

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 62.19  E-value: 1.04e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAAANSLLIALICTQPALRN---TSNFFLVSLFTSDLMVGLVVMPPAMLNALYGR--WVLARGLCLLWTAF 105
Cdd:cd15356   5 AVYALIWALGAAGNALTIHLVLKKRSLRGlqgTVHYHLVSLALSDLLILLISVPIELYNFVWFHypWVFGDLVCRGYYFV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  106 DVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWsLAALASFLPL--LLGW-HELGHAR-PPVPGQ-- 179
Cdd:cd15356  85 RDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIW-ASSLGFALPMafIMGQkYELETADgEPEPSSrv 163
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 4504545  180 CRLLASLP----FVLVASGLTFFLPSGAICFTYCRILLAARKQAVQ 221
Cdd:cd15356 164 CTVLVSRAtlkvFIQVNAFVSFVLPLALIAFLNGVTVSHLRIQSLQ 209
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
29-331 1.13e-10

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 62.07  E-value: 1.13e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd14999   2 IGTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLY-LLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALaLVLGAWsLAALASFLPLLLgWHELGHARPPVPGQCRLLASLP- 187
Cdd:cd14999  81 TMHASIFTLTVMSTERYLAVVKPLDTVKRSKSYRKL-LAGVIW-LLSLLLTLPMAI-MIRLVTVEDKSGGSKRICLPTWs 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 ------FVLVASGLTFFLPSGAICFTYCRIllaarkqavqvasLTTGMASQAsetlqvprtprpgveSADSRRLATKHSR 261
Cdd:cd14999 158 eesykvYLTLLFSTSIVIPGLVIGYLYIRL-------------ARKYWLSQA---------------AASNSSRKRLPKQ 209
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  262 KALKasLTLGILLgMFFVTWLPFFVANIVQAVCDCISPG------LFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd14999 210 KVLK--MIFTIVL-VFWACFLPFWIWQLLYLYSPSLSLSprtttyVNYLLTCLTYSNSCINPFLYTLLTKNYKEYL 282
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
44-331 1.18e-10

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 61.73  E-value: 1.18e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVL---ARGLCLLWTAFDVMCCSA---SILNL 117
Cdd:cd15351  18 NILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLvcrAPMLQHMDNVIDTMICSSvvsSLSFL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  118 CLISLDRYLLILSPLRYKLRMTPLRALALVLGAWsLAALASFLpLLLGWHElgharppvpGQCRLLASLPFVLVASGLTF 197
Cdd:cd15351  98 GAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIW-LASTVSST-LFIVYYN---------SNAVILCLIVFFLFMLVLML 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  198 FLpsgaicftYCRILLAARKQAVQVASLttgmasqasetlqvprtprpgvesadSRRLATKHSRKALKASLTLGILLGMF 277
Cdd:cd15351 167 VL--------YIHMFILACRHSQSISSQ--------------------------QRRQCPHQQTASLKGAITLTILLGIF 212
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  278 FVTWLPFFVANIV------QAVCDCISpGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15351 213 FLCWGPFFLHLTLivtcptHPFCLCYF-KYFNLFLILIICNSIIDPLIYAFRSQELRKTL 271
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
31-331 1.25e-10

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 61.78  E-value: 1.25e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVI-ALTAAANSLLIALICTQPALRNT-SNFFLVSLFTSDLMVGlVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15341   4 AVLCTLCgLLCILENVAVLYLILSSPKLRRKpSYLFIGSLALADFLAS-VVFACSFVDFHVFHGVDSSAIFLLKLGGVTM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWHELgharpPVPGQC-RLLASLP 187
Cdd:cd15341  83 SFTASLGSLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIAYLP-LMGWNCC-----PLNSPCsELFPLIP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 FVLVASGLTF--FLPSGaICFTYCRILLAARKQAVQVASlttgmasqaSETLQVPRTPRpgvesadsrrlatkhSRKALK 265
Cdd:cd15341 157 NDYLLSWLLLvaILLSG-IIYTYGHVLWKAHKHVVYMEK---------HQDQQGPGNAR---------------MRLDVR 211
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  266 ASLTLGILLGMFFVTWLP---FFVANIVQAVCDCISPgLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15341 212 LAKTLGLVLAVLLICWSPvlaLMMHSLFTSLSDHIKK-AFAFCSTLCLVNSMVNPIIYALRSRELRSSL 279
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
35-331 1.84e-10

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 61.37  E-value: 1.84e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALR---NTSNFFLVSLFTSDLMVGLVVmpPAMLNALYGR--WVLARGLCLLWTAFDVMC 109
Cdd:cd15338   9 VICFLGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLLFLLGM--PFLIHQLLGNgvWHFGETMCTLITALDTNS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  110 CSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLaalaSFLPLLLGWHELGHArpPVPG---QCRLLASL 186
Cdd:cd15338  87 QITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWIL----SLLSITPVWMYAGLM--PLPDgsvGCALLLPN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  187 P------FVLVASGLTFFLPSGAICFTYCRILLaarkqavqvaSLTTGMASQASETLQVpRTprpgvesadsrrlaTKHS 260
Cdd:cd15338 161 PetdtywFTLYQFFLAFALPLVVICVVYFKILQ----------NMASTVAPLPQRSLRV-RT--------------KKVT 215
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504545  261 RKALKASLtlgillgMFFVTWLPFFVANIVQAVCDCISPG---LFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15338 216 RMAVAICL-------AFFICWAPFYILQLAHLSIDRPSLAflyAYNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
44-329 2.58e-10

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 60.72  E-value: 2.58e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLV-VMPPAMLNALYGRWVLARGLCL--LWTAFDVMCC---SASILNL 117
Cdd:cd15354  18 NILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSnAWETITIYLLNNRHLVIEDAFVrhIDNVFDSLICisvVASMCSL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  118 CLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLgwhelgharppvpgqcrllASLPFVLVASGLTF 197
Cdd:cd15354  98 LAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTGCGIIFILY-------------------SESTYVIICLITMF 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  198 FLPSGAICFTYCRILLAARKQAVQVASLttgmasqasetlqvprtprPGVESAdsrrlatkHSRKALKASLTLGILLGMF 277
Cdd:cd15354 159 FAMLFLMVSLYIHMFLLARTHVKRIAAL-------------------PGYNSV--------RQRTSMKGAVTLTILLGIF 211
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  278 FVTWLPFFVANIVQAVCD----CIS-PGLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15354 212 IVCWAPFFLHLILMISCPqnlyCVCfMSHFNMYLILIMCNSVIDPLIYAFRSQEMRK 268
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
32-156 2.65e-10

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 60.99  E-value: 2.65e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   32 ALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCS 111
Cdd:cd15399   6 AYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAVH 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 4504545  112 ASILNLCLISLDRYLLILSPLRYKLRMtplRALALVLG-AWSLAAL 156
Cdd:cd15399  86 VSTVTLTVIALDRHRCIVYHLESKISK---KISFLIIGlTWAASAL 128
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
29-329 2.89e-10

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 60.91  E-value: 2.89e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLClLWTAFDVM 108
Cdd:cd15086   3 VAVFLGFILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGC-RWYGFANS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCS-ASILNLCLISLDRYLLILSPLryKLRMTPLR-ALALVLGAWsLAALASFLPLLLGWHELGHARP----PVPGQCRL 182
Cdd:cd15086  82 LFGiVSLISLAVLSYERYCTLLRPT--EADVSDYRkAWLGVGGSW-LYSLLWTLPPLLGWSSYGPEGPgttcSVQWTSRS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  183 LASLPFVLVASGLTFFLPSGAICFTYCRILLAARkqavQVASLTTGMAsqasetlqvprtprpgvesadsrrlatkhSRK 262
Cdd:cd15086 159 ANSISYIICLFIFCLLLPFLVMVYCYGRLLYAIK----QVGKINKSTA-----------------------------RKR 205
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  263 ALKASLTLGILLGMFFVTWLPFFVANIVQAV--CDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15086 206 EQHVLLMVVTMVICYLLCWLPYGVMALLATFgkPGLVTPVASIVPSILAKSSTVVNPIIYVFMNKQFYR 274
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
29-218 7.50e-10

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 59.39  E-value: 7.50e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALR-NTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDV 107
Cdd:cd15219   2 LAVLLVVVLVVSLLSNLLVLLCFLYSAELRkQVPGIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLET 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHA-------RPPVPGQC 180
Cdd:cd15219  82 FLTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFLSWLGYSSLyasctlhLPREEERR 161
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 4504545  181 RLlasLPFVLVASGLTFFLPSGAICFTYCRILLAARKQ 218
Cdd:cd15219 162 RF---AVFTAFFHAFTFLLSLLVLCVTYLKVLKVRRRQ 196
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
39-214 1.09e-09

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 58.83  E-value: 1.09e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLC 118
Cdd:cd15237  13 LTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVTECVLLA 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLL-------GWHELGHARPPVPGQCRLL-----ASL 186
Cdd:cd15237  93 VMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLtlrlpfcGPNHINHFFCEAPAVLKLAcadtsLNE 172
                       170       180
                ....*....|....*....|....*...
gi 4504545  187 PFVLVASGLTFFLPSGAICFTYCRILLA 214
Cdd:cd15237 173 AVIFVTSVLVLLIPFSLILASYIRILAT 200
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
35-212 1.46e-09

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 58.61  E-value: 1.46e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQpALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15372   9 LVFLVGLPANGLALWVLATQ-VKRLPSTIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFFYGNMYCSV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWsLAALASFLPLLLGWHELGHARPPV-------PGQCRLLASLP 187
Cdd:cd15372  88 LLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIW-LIAAALTLPLTLQRQSYPLERLNItlchdvlPLDEQDTYLFY 166
                       170       180
                ....*....|....*....|....*
gi 4504545  188 FVLVASGLTFFLPSGAICFTYCRIL 212
Cdd:cd15372 167 YFACLAVLGFLLPLVVILFCYGSVL 191
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
44-328 1.92e-09

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 58.33  E-value: 1.92e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLClLWTAFDVMCCS-ASILNLCLISL 122
Cdd:cd15085  18 NVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFC-IFQGFAVNYFGiVSLWSLTLLAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  123 DRYLLILSPLRyKLRMTPLRALALVLGAWSLAALASFLPlLLGWHELGHArpPVPGQC------RLLASLPFVLVASGLT 196
Cdd:cd15085  97 ERYNVVCKPMG-GLKLSTKRGYQGLLFIWLFCLFWAVAP-LFGWSSYGPE--GVQTSCsigweeRSWSNYSYLILYFLMC 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  197 FFLPSGAICFTYCRILLAARKQAVQVASLttGMASQASETLQVPRtprpgvesadsrrlatkhsrkalkasLTLGILLGm 276
Cdd:cd15085 173 FVIPVAIIGFSYGNVLRSLHKLNKKIEQQ--GGKNCPEEEERAVI--------------------------MVLAMVIA- 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 4504545  277 FFVTWLPFFVANIVQAVCD--CISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFK 328
Cdd:cd15085 224 FLICWLPYTVFALIVVVNPelSISPLAATMPTYFAKTSPVYNPIIYIFLNKQFR 277
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
107-320 2.67e-09

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 57.87  E-value: 2.67e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  107 VMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLlgwheLGHARPPVpgqcrllasL 186
Cdd:cd15350  87 CLSLLGSIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTFCGGSGILMIL-----FFHFVATV---------I 152
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  187 PFVLVasgltFFLPSGAICFTYCRILLAARKQAVQVASLTTGMAsqasetlqvprtprpgvesadsrrlatKHSRKALKA 266
Cdd:cd15350 153 CFTVL-----FFLMLVLILCLYVHMFLLARSHARKIASLPNHHA---------------------------QHQRSNMRG 200
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  267 SLTLGILLGMFFVTWLPFFVANIVQAV------CDCISpGLFDVLTWLGYCNSTMNPIIY 320
Cdd:cd15350 201 AITLTILLGVFVCCWAPFVLHLLLMMFcpmnpyCACYR-SLFQVNGTLIMSHAVIDPAIY 259
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
29-329 2.77e-09

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 58.04  E-value: 2.77e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15091   3 ITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALV-TTTMPFQSTVYLMNSWPFGDVLCKIVISIDYY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPV------PGQCRL 182
Cdd:cd15091  82 NMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDSTecslqfPDDDYS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  183 LASLPFVLVASGLTFFLPsgAICFTYCRILLAARKQAVQVASlttgmasqasetlqvprtprpgvesadSRRLATKHSRK 262
Cdd:cd15091 162 WWDTFMKICVFIFAFVIP--VLIIIVCYTLMILRLKSVRLLS---------------------------GSREKDRNLRR 212
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504545  263 ALKASLtlgILLGMFFVTWLPFFVANIVQAVCD------CISPGLFDVLtwLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15091 213 ITRLVL---VVVAVFVVCWTPIHIFILVEALGSvshstaAVSSYYFCIA--LGYTNSSLNPILYAFLDENFKR 280
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
29-329 2.78e-09

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 58.00  E-value: 2.78e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15401   3 LAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKlRMTPLRALALVLG-AWSLAALASFLPLLLGWHELGharpPVPGQCRL--LAS 185
Cdd:cd15401  83 SVIGSVFNITAIAINRYCYICHSLRYD-KLYNMKKTCCYVClTWVLTLAAIVPNFFVGSLQYD----PRIYSCTFaqTVS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 LPFVLVASGLTFFLPSGAICFTYCRILLAarkqAVQVASlttgmasqasetlQVPRTPRPGVESADSRRLatkhsrkalk 265
Cdd:cd15401 158 SSYTITVVVVHFIVPLSIVTFCYLRIWVL----VIQVKH-------------RVRQDSKQKLKANDIRNF---------- 210
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  266 asLTLGILLGMFFVTWLPFFVANIVQA-----VCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15401 211 --LTMFVVFVLFAVCWGPLNFIGLAVAinplkVAPKIPEWLFVLSYFMAYFNSCLNAVIYGVLNQNFRK 277
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
44-331 3.03e-09

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 57.83  E-value: 3.03e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLD 123
Cdd:cd15192  18 NSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKIASALVSFNLYASVFLLTCLSID 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  124 RYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLLgWHELGHARPPVPGQCRLL-----ASLPFV--LVASGLT 196
Cdd:cd15192  98 RYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVAS-LPAII-HRDVFFIENTNITVCAFHypsqnSTLLVGlgLMKNLLG 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  197 FFLPSGAICFTYCRIlLAARKQAVQvaslttgmasqasetlqvprtprpgVESADSRrlatkhSRKALKASLTLGIllgM 276
Cdd:cd15192 176 FLIPFLIILTCYTLI-GKALKKAYE-------------------------IQRNKPR------NDEIFKMIMAVVL---F 220
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  277 FFVTWLPFFVANIVQA------VCDCISPGLFD----VLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15192 221 FFFCWIPHQIFTFLDVliqlkvIQDCHIADIVDtampFTICIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
28-319 3.18e-09

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 57.46  E-value: 3.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALtaaANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVV--MPPAMLNALYGRWvlargLCLLWTAF 105
Cdd:cd15905   3 WLSVPLSSLIIF---ANLFIILGIACNRKLHNTANYFFLSLLLADLLTGVALpfIPGMSNESRRGYH-----SCLFVYVA 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  106 DVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWHelgHARPPVPGQCRLLAS 185
Cdd:cd15905  75 PNFLFLSFLANLLMVHYERYLCIVYPLQYHNFWVHRWVPLALLLTWALPLLFACLP-ALGWN---NWTPGSNCSYKQVFP 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 LPFVLVASgLTFFLPS-GAICFTYCRILLAARKQAVQVASLTTGMASQASetlqvprtprpgveSADSRRLATKHSRKAL 264
Cdd:cd15905 151 AAYIYLEV-YGLVLPSiLAIAFMSVRVLAVARRQLQDICKLLRAVQRDGP--------------SELEQQLNLRYAKCIA 215
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  265 KASLTlgillgmFFVTWLPFFVANIV-----QAVCDCiSPGLFDVLTWLGYCNSTMNPII 319
Cdd:cd15905 216 GVSLT-------FLVCWVPYIAYLLMsvlaiEQRPPL-SPGTLLILSCVGSGSAAAVPVI 267
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
44-320 3.51e-09

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 57.59  E-value: 3.51e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLV-VMPPAMLNALYGRWVLARG--LCLLWTAFDVMCC---SASILNL 117
Cdd:cd15352  18 NILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSnSLETIMIAVLNSGYLVISDqfIQHMDNVFDSMICislVASICNL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  118 CLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELgharppvpgqcrllaslpfVLVASGLTF 197
Cdd:cd15352  98 LAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGIVFIVYSESKT-------------------VIVCLITMF 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  198 FLPSGAICFTYCRILLAARKQAVQVASLTtgmasqasetlqvprtprPGVESADSRrlatkhsRKALKASLTLGILLGMF 277
Cdd:cd15352 159 FAMLVLMATLYVHMFLFARLHVKRIAALP------------------PAVDGAPQQ-------RSCMKGAVTITILLGVF 213
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 4504545  278 FVTWLPFFVANIVQAVCD----CIS-PGLFDVLTWLGYCNSTMNPIIY 320
Cdd:cd15352 214 IVCWAPFFLHLILIISCPhnpyCLCyTSHFNTYLVLIMCNSVIDPLIY 261
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
32-214 3.61e-09

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 57.56  E-value: 3.61e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   32 ALCVVIALTA-AANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCC 110
Cdd:cd15421   5 SLILLIFLVAlTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  111 SASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFL--PLLL-----GWHELGHARPPVPGQCRL- 182
Cdd:cd15421  85 GAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIhtVYTMhfpycGSREIHHFFCEVPALLKLs 164
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 4504545  183 ----LASLPFVLVASGLTFFLPSGAICFTYCRILLA 214
Cdd:cd15421 165 cadtSAYETVVYVSGVLFLLIPFSLILASYALILLT 200
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
29-331 5.48e-09

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 56.71  E-value: 5.48e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVI-ALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMP------PAMLNALYGRWVLARGlcLL 101
Cdd:cd15102   2 ATSVVFVAIcCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLAnillsgARTLRLSPAQWFLREG--SM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  102 WTAFdvmccSASILNLCLISLDRYLLILSPLRYKLRMTpLRALALVLGAWSLAALASFLPlLLGWHELGHArpPVPGQCR 181
Cdd:cd15102  80 FVAL-----SASVFSLLAIAIERHLTMAKMKPYGASKT-SRVLLLIGACWLISLLLGGLP-ILGWNCLGAL--DACSTVL 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  182 LLASLPFVLVASgLTFFLPSGAICFTYCRILLAARKQAVQVAslttgmasqasetlqvprtprpgvesADSRRlatkhsR 261
Cdd:cd15102 151 PLYSKHYVLFCV-TIFAGILAAIVALYARIYCLVRASGRKAT--------------------------RASAS------P 197
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504545  262 KALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCIS-PGLF--DVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15102 198 RSLALLKTVLIVLLVFIACWGPLFILLLLDVACPVKTcPILYkaDWFLALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
65-330 5.83e-09

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 57.11  E-value: 5.83e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   65 LVSLFTSDLMVGLVVMPPAMLNALYG--RWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKlRMTPLR 142
Cdd:cd15135  42 MVSLACSDLLVLLLGMPVELYSAIWDpfATPSGNIACKIYNFLFEACSYATILNVATLSFERYIAICHPFKYK-ALSGSR 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  143 ALALVLGAWSLAALASfLPLLLG---------WHELGHARPPVPGQ------CRLLASLPFVLVASGLTFF------LPS 201
Cdd:cd15135 121 VRLLICFVWLTSALVA-LPLLFAmgtedpleaFPSYRGTRHHCQDQksnltiCTSLSSKWTVFQASIFSAFvlyllvLAS 199
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  202 GAI-CFTYCRILLAARKQAVQVASlttgmasqasetlqvPRTPRPGVESADSRRlaTKHSRKalKASLTLGILLGMFFVT 280
Cdd:cd15135 200 VAFmCRRMMRALMGSKKGAVAVKG---------------PGGSVQLLRKHESAE--GKTARK--QTILFLGLIVGTLAVC 260
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  281 WLPFFVANIVQAVC---DCISPGLFDVLTWLG------YCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15135 261 WMPNQIRRIMAAAKpkdDWTRSYFRAYIILLPiadtffYLSSVLNPLLYNLSSQQFRSV 319
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
35-331 6.21e-09

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 56.83  E-value: 6.21e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTS-NFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSAS 113
Cdd:cd15926   9 VVCALGLVGNLLVLYLMKSKQGWKKSSiNLFVTSLAVTDFQFVLTLPFWAVENALDFTWLFGKAMCKIVSYVTAMNMYAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  114 ILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPlllgwHELGHARPPVPGQCRLLASLPFVLVAS 193
Cdd:cd15926  89 VFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILAS-LP-----NAIFSTTATVSNEELCLVKFPDNRGNA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  194 G------------LTFFLPSGAIcfTYCRILLaarkqavqvaslttgmasqasetlqvprtprpgVESADSRRLATKHSR 261
Cdd:cd15926 163 QfwlglyhaqkvlLGFLIPLGII--SLCYLLL---------------------------------VRFITDKNITGSSTK 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  262 KALKASLTLGILLGMFFVTWLP---------FFVANIVQAVCDCISPG--LFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15926 208 RRSKVTKSVTIVVLSFFLCWLPnqalttwgiLIKLNVVHFSYEYFTTQvyIFPITVCLAHSNSCLNPILYCLMRREFRKA 287

                .
gi 4504545  331 L 331
Cdd:cd15926 288 L 288
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
35-164 7.59e-09

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 56.56  E-value: 7.59e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15411   9 VIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTEC 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLL 164
Cdd:cd15411  89 FLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTL 138
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
28-221 7.66e-09

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 56.24  E-value: 7.66e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTA-AANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGR--WVLARGLCLLWTA 104
Cdd:cd14995   1 VVATFLVLLICGVGiVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAGLPNEIESLLGPdsWIYGYAGCLLITY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  105 FDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLA 184
Cdd:cd14995  81 LQYLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLSIKHYGDDIVVRCGYKV 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 4504545  185 S----LPFVLVASGLTFFLPSGAICFTY---CRILLAARKQAVQ 221
Cdd:cd14995 161 SrhyyLPIYLADFVLFYVIPLLLAIVLYgliGRILFSSRKQVTK 204
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
29-329 9.22e-09

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 56.39  E-value: 9.22e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRN---TSNFFLVSLFTSDLMVGLVVMPPAMLNALYGR--WVLARGLCLLWT 103
Cdd:cd15355   3 VTAIYLALFVVGTVGNSITLYTLARKKSLQHlqsTVHYHLASLALSDLLILLLAMPVELYNFIWVHhpWAFGDAACRGYY 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  104 AFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWsLAALASFLPLLLGWHELgHARPPVPGQ---C 180
Cdd:cd15355  83 FLRDACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIW-LASALLAIPMLFTMGEQ-NRSGTHPGGlicT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  181 RLLASLPFVLVASG---LTFFLPsgaicftycriLLAARKQAVQVASLTTGMASQASETLQV--PRTPRPG--VESADSR 253
Cdd:cd15355 161 PIVDTSTLKVVIQVnafLSFLFP-----------MLVISVLNTLIANQLTVMVNQAEQENQVctIGGQRTVlsVSMEPGR 229
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  254 RLATKHSRKALKAsltlgiLLGMFFVTWLPFFVANIVqaVC----DCISPGLFD-------VLTWLGYCNSTMNPIIYPL 322
Cdd:cd15355 230 VQSLRHGVLVLRA------VVIAFVVCWLPYHVRRLM--FCyvsdEQWTTFLYDfyhyfymLTNVLFYVSSAINPILYNL 301

                ....*..
gi 4504545  323 FMRDFKR 329
Cdd:cd15355 302 VSANFRQ 308
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
29-158 1.15e-08

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 55.91  E-value: 1.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15191   3 IPVLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYNWLFGSVMCKICGSLLTL 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKlRMTPLRALALVLGAWSLAALAS 158
Cdd:cd15191  83 NLFASIFFITCMSVDRYLAVVYPLRSQ-RRRSWQARLVCLLVWVLACLSS 131
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
44-329 1.16e-08

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 55.91  E-value: 1.16e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLD 123
Cdd:cd15193  18 NLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFIIAVNRCSSILFLTGMSVD 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  124 RYLLILSPLRYKLRMTPLRALALVLGAWSLAalasflpLLLGWHELGHARPPVPGQC----RLLASLPFVLVASGLTFFL 199
Cdd:cd15193  98 RYLAVVKLLDSRPLRTRRCALITCCIIWAVS-------LVLGIPSLVYRNLINESVCvedsSSRFFQGISLATLFLTFVL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  200 PSGAICFTYCRILLAARkqavqvaslttgmasqaSETLQVPRTPRpgvesadsRRlatKHSRKALKASLTlgillgMFFV 279
Cdd:cd15193 171 PLIVILFCYCSILVRLR-----------------RHFHGAKRTGR--------RR---RNSLRIVFAIVT------AFVL 216
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  280 TWLPFFVANIVQAVCDCI----SPGLFDVLTW-------LGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15193 217 SWLPFNTLKAVRLLLELGggvlPCHTTVAIRQgltitacLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
44-329 1.35e-08

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 55.68  E-value: 1.35e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCL--LWTAFDVMCCS---ASILNLC 118
Cdd:cd15353  18 NILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLNGNDTDAQSFTvnIDNVIDSVICSsllASICSLL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLgwhelgharppvpgqcrllASLPFVLVASGLTFF 198
Cdd:cd15353  98 SIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSGVLFIIY-------------------SDSSVVIICLISMFF 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  199 LPSGAICFTYCRILLAARKQAVQVASLT-TGMASQASEtlqvprtprpgvesadsrrlatkhsrkaLKASLTLGILLGMF 277
Cdd:cd15353 159 TMLALMASLYVHMFLLARLHIKRIAVLPgTGPIRQGAN----------------------------MKGAITLTILLGVF 210
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  278 FVTWLPFFVANIVQAVCD----CIS-PGLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15353 211 VVCWAPFFLHLIFYISCPrnpyCVCfMSHFNMYLILIMCNSVIDPLIYAFRSQELRK 267
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
110-331 1.41e-08

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 55.67  E-value: 1.41e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  110 CSASILNLCLISLDRYLLILSPLRYKlRMTPLRALALVLGAWSLAALASFLPlLLGWHELGH-------------ARPPV 176
Cdd:cd15137  91 SEVSVLILTLITLDRFICIVFPFSGR-RLGLRRAIIVLACIWLIGLLLAVLP-LLPWDYFGNfygrsgvclplhiTDERP 168
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  177 PGQcrlLASLPFVLVASGLTFFLpsgaICFTYCRILLAARKqavqvaslttgmasqaseTLQVPRTPRPGVESADSRRla 256
Cdd:cd15137 169 AGW---EYSVFVFLGLNFLAFVF----ILLSYIAMFISIRR------------------TRKAAASRKSKRDMAVAKR-- 221
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  257 tkhsrkalkasltlgillgMFFVT------WLPFFVANIVqAVCDCISPGlfDVLTWLGY----CNSTMNPIIYPLFMRD 326
Cdd:cd15137 222 -------------------FFLIVltdflcWIPIIVIGIL-ALSGVPIPG--EVYAWVAVfvlpINSALNPILYTLSTPK 279

                ....*
gi 4504545  327 FKRAL 331
Cdd:cd15137 280 FRKKL 284
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
29-331 1.50e-08

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 55.69  E-value: 1.50e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIA-LTAAANSLLIALICTQPALRNTSNF-FLVSLFTSDLMvGLVVMPPAMLNALYGRWVLARGLCLLWTAFD 106
Cdd:cd15340   2 AIAVLSLTLGtFTVLENLLVLCVILHSRSLRCRPSYhFIGSLAVADLL-GSVIFVYSFLDFHVFHRKDSPNVFLFKLGGV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  107 VMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGW-----HELGHARPPVPGQCR 181
Cdd:cd15340  81 TASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRTKAVIAFCVMWTIAIVIAVLP-LLGWnckklNSVCSDIFPLIDETY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  182 LLAslpFVLVASGLTFFlpsgaICFTYCRILLAARKQAVQVASLTT--GMASQASETLQVpRTPRPgvesadsrrlatKH 259
Cdd:cd15340 160 LMF---WIGVTSVLLLF-----IVYAYMYILWKAHHHAVRMLQRGTqkSIIVYTSEDGKV-QTTRP------------DQ 218
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  260 SRKALKASLTLGILLGMFFVTWLPFF---VANIVQAVCDCISPgLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15340 219 TRMDIRLAKTLVLILVVLIICWGPLLaimVYDVFGKMNKLIKT-VFAFCSMLCLLNSTVNPIIYALRSKDLRHAF 292
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
32-328 1.57e-08

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 55.52  E-value: 1.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   32 ALCVVIALtaAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYGrWVLARGLCLLWTAFDVMCCS 111
Cdd:cd15176   8 TIALVVGL--AGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLL-LFTLPFWAADAVNG-WVLGTAMCKITSALYTMNFS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  112 ASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLgaWSLAALASFLPLLLG---WHELGHA-RPPVPGQCRLLASLP 187
Cdd:cd15176  84 CGMQFLACISVDRYVAITKATSRQFTGKHCWIVCLCV--WLLAILLSIPDLVFStvrENSDRYRcLPVFPPSLVTSAKAT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 FVLVASGLTFFLPSGAICFTYCRIllaarkqavqvaslttgmasqASETLQVPRTPRpgvesadsrrlatkhsRKALKAS 267
Cdd:cd15176 162 IQILEVLLGFVLPFLVMVFCYSRV---------------------ARALSRTPNVKK----------------SRALKVL 204
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4504545  268 LTlgiLLGMFFVTWLPFFVANIVQA-------VCDCISPGLFD----VLTWLGYCNSTMNPIIYPLFMRDFK 328
Cdd:cd15176 205 LA---VVGVFIVTQLPYNVVKFYRAidviyllITDCSMSKTLDiaiqVTESIALFHSCLNPVLYVFMGASFK 273
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
30-320 2.09e-08

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 55.26  E-value: 2.09e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   30 AAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMC 109
Cdd:cd16002   4 AVAYSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  110 CSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLgaWSLAALASFlplLLGWHELGHarpPVPGQCRLLASLP-- 187
Cdd:cd16002  84 VFASIYSMTAIALDRYMAIIHPLQPRLSATATKVVICVI--WVLAFLLAF---PQGYYSDTE---EMPGRVVCYVEWPeh 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 ---------FVLVASGLtFFLPSGAICFTYCRIllaarkqavqvaslttGMASQASETlqvprtprPGvESADSRRLATK 258
Cdd:cd16002 156 eerkyetvyHVCVTVLI-YFLPLLVIGCAYTVV----------------GITLWASEI--------PG-DSSDRYHEQVS 209
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  259 HSRKALKASLtlgILLGMFFVTWLPFFVANIVQAvcdcISPGLFD---------VLTWLGYCNSTMNPIIY 320
Cdd:cd16002 210 AKRKVVKMMI---VVVCTFAICWLPYHIYFLLQY----FHPELYEqkfiqqvylAIMWLAMSSTMYNPIIY 273
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
32-323 2.21e-08

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 55.20  E-value: 2.21e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   32 ALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMV-GLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCC 110
Cdd:cd15198   6 FLGVILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLViGGTALSQIIWELLGDRWMAGDVACRLLKLLQASAR 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  111 SASILNLCLISLDRYLLILSPLRyklrmTPLRALALVLGAWSLAALASFLPL-LLGWHELGHARPPVPGQ--CR-LLASL 186
Cdd:cd15198  86 GASANLVVLLALDRHQAIRAPLG-----QPLRAWKLAALGWLLALLLALPQAyVFRVDFPDDPASAWPGHtlCRgIFAPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  187 P------FVLVASGLTFFLPSGAICFTYCRILLAARKQavqvaslttgmASQASETLQVPRTPRPGVESADSRRLATKHS 260
Cdd:cd15198 161 PrwhlqvYATYEAVVGFVAPVVILGVCYGRLLLKWWER-----------ANQAPGAKKPWKKPSKSHLRATAPSALPRAK 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  261 RKALKASLTLGILlgmFFVTWLPFFVANIVQAVC--DCISPGLFDVLTWLGYCNSTMNPIIYPLF 323
Cdd:cd15198 230 VKTLKMTLVIALL---FVGCSLPYFIAELAAAFGsgDWEPEKVAAALGVMAVANSATNPFVFLFF 291
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
28-331 2.85e-08

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 54.74  E-value: 2.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVvMPPAMLNALYGRWVLARGLCLLWTAFDV 107
Cdd:cd15087   2 ALPVIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLV-LPINIAEHLLQQWPFGELLCKLILSIDH 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLRYklRMTPLR----ALALVLGAWSLAALAsFLPLLL--GWHELGHARP------P 175
Cdd:cd15087  81 YNIFSSIYFLTVMSVDRYLVVLATVRS--RRMPYRtyraAKIVSLCVWLLVTII-VLPFTVfaGVYSNELGRKscvlsfP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  176 VPGQCRLLASLPFVLVasgLTFFLPSGAICFTYCRILLAARKQavqvaslttgmasqasetlqvprtprpgveSADSRRL 255
Cdd:cd15087 158 SPESLWFKASRIYTLV---LGFAIPVSTICILYTMMLYKLRNM------------------------------RLNSNAK 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  256 ATKHSRKalKASLTLGILLGMFFVTWLPFFVANIVQAVCDC----ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15087 205 ALDKAKK--KVTLMVLVVLAVCLFCWTPFHLSTVVALTTDLpqtpLVIGISYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
39-164 3.19e-08

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 54.41  E-value: 3.19e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLC 118
Cdd:cd13954  13 LTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLGGTECFLLA 92
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLL 164
Cdd:cd13954  93 VMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVL 138
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
44-330 3.23e-08

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 54.79  E-value: 3.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLD 123
Cdd:cd15094  18 NGLVIYVVLRYAKMKTVTNLYILNLAVADECF-LIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFTSSFTLTVMSAD 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  124 RYLLILSPLRYKLRMTPLRALALVLGAWSLAALAsFLPLLLgwheLGHARPPVPGQ-CRLL--------ASLPFVLVASG 194
Cdd:cd15094  97 RYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLV-MLPIIL----YASTVPDSGRYsCTIVwpdssavnGQKAFTLYTFL 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  195 LTFFLPSGAICFTYCRILLAARkqavqvaslTTGmasqasetlqvprtprPGVESADSRRlatKHsRKALKASLTlgiLL 274
Cdd:cd15094 172 LGFAIPLLLISVFYTLVILRLR---------TVG----------------PKNKSKEKRR---SH-RKVTRLVLT---VI 219
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  275 GMFFVTWLPFFVAnivQAVCDCISPG---------LFDVLTWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15094 220 SVYIICWLPYWAF---QVHLIFLPPGtdmpkweilMFLLLTVLSYANSMVNPLLYAFLSENFRKS 281
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
30-331 3.53e-08

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 54.44  E-value: 3.53e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   30 AAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMppamLNALYGRWVLARGLCLLWTAFD--- 106
Cdd:cd15348   4 AVAFLAVCAFIVLENLIVLLALWRNKKFHSPMFYLLGSLTLSDLLAGAAYA----ANILMSGANTLKLTPALWFLREggv 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  107 VMCCSASILNLCLISLDRYLLILsplryklRMTPL------RALALVLGAWSLAALASFLPLLlGWHELGhaRPPVPGQC 180
Cdd:cd15348  80 FITLTASVFSLLAIAIERHITMV-------RMKPYpgdkrgRMFLLIGAAWLVSILLGVLPIL-GWNCLG--NLDACSTV 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  181 RLLASLPFVLVASgLTFFLPSGAICFTYCRILLAARKQAVQVASLTTgmasqasetlqvprtprpgvesadsRRLATKHS 260
Cdd:cd15348 150 LPLYAKSYILFCI-TVFLAILAAIVVLYARIYRIVKANSQRLGALPT-------------------------RKGRARRS 203
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504545  261 RKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLF---DVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15348 204 QKYLALLKTVTIVLGTFVACWLPLFLLLLLDVSCPAQACPVLlkaDYFLGLAMINSLLNPIIYTLTSRDMRRAI 277
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
29-320 3.82e-08

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 54.46  E-value: 3.82e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAaaNSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd16004   5 IAYSLIVLVAVTG--NATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPIT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALalVLGAWSLAALASFLPLLLGWHELGHARPPV----PGQCRLLA 184
Cdd:cd16004  83 AMFVSIYSMTAIAADRYMAIIHPFKPRLSAGSTKVV--IAGIWLVALALAFPQCFYSTVTMDQGRTKCivawPGDSGGKH 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  185 SLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVqvaslttgmasqasetlqvprtprPGVESADSRRLATKHSRKAL 264
Cdd:cd16004 161 QLTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAV------------------------PGHQAHGAYHRQLQAKKKFV 216
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  265 KaslTLGILLGMFFVTWLPFFVANIVQAV-----CDCISPGLFDVLTWLGYCNSTMNPIIY 320
Cdd:cd16004 217 K---TMVVVVVTFAICWLPYHLYFILGSFnediyCQKYIQQVYLAIFWLAMSSTMYNPIIY 274
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
59-331 4.19e-08

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 54.34  E-value: 4.19e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   59 NTSNFFLVSLFTSDLmVGLVVMPpaMLNALYGRWVlarglcllWTAFDVMCCS----------ASILNLCLISLDRYLLI 128
Cdd:cd15378  33 KSSNIYLFNLSVSDL-AFLCTLP--MLVYSYSNGQ--------WLFGDFLCKSnryllhanlySSILFLTFISIDRYLLI 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  129 LSPLRYKLRMTPLRALALVLGAWSLAALaSFLPLLLgwhELGHARPPVPGQCRLLASL----PFVLVASGLT---FFLPS 201
Cdd:cd15378 102 KYPFREHILQKKRSAVAISLAIWVLVTL-ELLPILT---FIGPNLKDNVTKCKDYASSgdatNSLIYSLFLTvtgFLIPL 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  202 GAICFTYCRILLAARKQAVQVASLTTgmasqasetlqvprtprpgvesadsrrlatkhsrkaLKASLTLGILLG-MFFVT 280
Cdd:cd15378 178 CVMCFFYYKIALFLKNRNRQLANATS------------------------------------FEKPLTLVILAVvIFSVL 221
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4504545  281 WLPFFVANIV--------QAVCDC---ISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15378 222 FTPYHVMRNVriasrldsIGVSECtliIIKSLYIVTRPIAFLNSVINPVFYFLMGDHFREML 283
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
43-320 4.29e-08

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 54.11  E-value: 4.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   43 ANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVM------PPAMLNALYGRWVLARGLclLWTAFdvmccSASILN 116
Cdd:cd15343  17 SNSLVIAAVVKNKRFHYPFYYLLANLAAADFFAGIAYVflmfntGPVSKTLTVNRWFLRQGL--LDTSL-----SASLTN 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  117 LCLISLDRYLLILSpLRYKLRMTPLRALALVLGAWSLAALASFLPLLlGWHELgharppvpgqCRLLA--SLPFVLVASG 194
Cdd:cd15343  90 LLVIAVERHISIMR-MKVHSNLTKRRVTLLIALVWAIAIFMGAVPTL-GWNCI----------CNISAcsSLAPIYSRSY 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  195 LTFFLPSGAICF-----TYCRILLAARKQAVQVASLTTGMASQAsetlqvpRTPrpgvesadsrrlatkhsrkaLKASLT 269
Cdd:cd15343 158 LVFWSVSNLVVFlimvvVYLRIYVYVQRKTNVLSPHTSGSINRR-------RTP--------------------IKLMKT 210
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 4504545  270 LGILLGMFFVTWLPFFVANIVQAVcDCISPGLFDVLTW---LGYCNSTMNPIIY 320
Cdd:cd15343 211 VMTVLGAFVICWTPGLVVLLLDGL-NCTRCGVQHVKRWfllLALLNSVMNPIIY 263
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
44-330 5.58e-08

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 53.96  E-value: 5.58e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIA-LICTQPALR-NTSNFFLVSLFTSDLMVGLVVMP-PAMLNALYGrWVLARGLCLLWTAFDVMCCSASILNLCLI 120
Cdd:cd15098  18 NSLVITvLARVKPGKRrSTTNVFILNLSIADLFFLLFCVPfQATIYSLPE-WVFGAFMCKFVHYFFTVSMLVSIFTLVAM 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  121 SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLA-ALAS--------FLPLLLGWHELGHARPPVPGQCRLLASLPFVlv 191
Cdd:cd15098  97 SVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSlAMASpvavhqdlVHHWTASNQTFCWENWPEKQQKPVYVVCTFV-- 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  192 asgLTFFLPSGAICFTYCRILLAARKQAvqvaslttgmasqasetlqvprtprpgvesadsRRLATKHSRKALKASLTLG 271
Cdd:cd15098 175 ---FGYLLPLLLITFCYAKVLNHLHKKL---------------------------------KNMSKKSERSKKKTAQTVL 218
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  272 ILLGMFFVTWLPFFVANIvqavcdCISPGLFD------VLTWLGYC----NSTMNPIIYPLFMRDFKRA 330
Cdd:cd15098 219 VVVVVFGISWLPHHIIHL------WVEFGDFPltqasfVLRITAHClayaNSCVNPIIYAFLSENFRKA 281
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
34-331 6.25e-08

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 53.71  E-value: 6.25e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   34 CVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLmVGLVVMPPAM-LNALYGRWVLARGLCLLWTAFDVMCCSA 112
Cdd:cd15194   8 CLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDF-IFLVTLPLWVdKEVVLGPWRSGSFLCKGSSYIISVNMYC 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  113 SILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVA 192
Cdd:cd15194  87 SVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYCNEDAGTPSKVIFSLVS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  193 SGLTFFLPSGAICFTYCRIllaARKQAVQVASlttgmasqasetlqvprtprpgvesadsrrlATKHSRKALKASLTLGI 272
Cdd:cd15194 167 LIVAFFLPLLSILTCYCTI---IWKLCHHYQK-------------------------------SGKHQKKLRKSIKIVFI 212
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  273 LLGMFFVTWLPF------FVANIVQAVCDCISPGL----FDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15194 213 VVAAFVFSWMPFnlfkalAIASGLQVEVTCLPYTLaqlgMEVSAPLAFANSCANPFIYYFFDRYIRRAI 281
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
39-167 6.56e-08

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 53.64  E-value: 6.56e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLC 118
Cdd:cd15912  13 LTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTTEFFLLA 92
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWH 167
Cdd:cd15912  93 VMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQ 141
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
35-331 6.73e-08

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 53.78  E-value: 6.73e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVS-LFTSDLMVGLVVMPPAMLN-------ALYGRWVLARGLCLLwtAFD 106
Cdd:cd14980   9 IIGILALIGNILVIIWHISSKKKKKKVPKLLIInLAIADFLMGIYLLIIAIADqyyrgryAQYSEEWLRSPPCLL--ACF 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  107 VMCCSA--SILNLCLISLDRYLLILSPLRYKlRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPP------VPG 178
Cdd:cd14980  87 LVSLSSlmSVLMMLLITLDRYICIVYPFSNK-RLSYKSAKIILILGWLFSIIFAAIPILYSINQPGDNRLYgyssicMPS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  179 QCRLLASLPFVLVASGLTF--FLpsgAICFTYCRILLAARKqavqvasltTGMASQASetlqvprtprpgvESADSRRLA 256
Cdd:cd14980 166 NVSNPYYRGWLIAYLLLTFiaWI---IICILYILIFISVRK---------SRKSARRS-------------SSKRDKRIA 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  257 TKhsrkalkasltLGILLGMFFVTWLPFFVANIvQAVcdcISPGLFDVLTwLGYC-------NSTMNPIIYPLFMRDFKR 329
Cdd:cd14980 221 IR-----------LALILITDLICWLPYYIVIF-SGL---LTSTEIDIHV-LQFIailalplNSAINPYLYTLTTPTFKR 284

                ..
gi 4504545  330 AL 331
Cdd:cd14980 285 DF 286
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
28-331 9.89e-08

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 53.07  E-value: 9.89e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLM--VGLVVMPPAMlnALYGRWVLARGLCLL--WT 103
Cdd:cd14974   1 IVSLVLYALIFLLGLPGNGLVIWVAGFKMKRTVNTVWFLNLALADFLfcLFLPFLIVYI--AMGHHWPFGSVLCKLnsFV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  104 AFDVMCCSasILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLLGW--HELGHARPPVPGQCR 181
Cdd:cd14974  79 ISLNMFAS--VFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLS-VPYFVFRdtVTHHNGRSCNLTCVE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  182 LLASLPFVLVASGLT-----FFLPSGAICFTYCRILLAARKqavqvaslttgmasqasetlqvprtprpgvesadsRRLA 256
Cdd:cd14974 156 DYDLRRSRHKALTVIrflcgFLLPLLIIAICYSVIAVKLRR-----------------------------------KRLA 200
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  257 TkhSRKALKASLTLGILlgmFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLG----YCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd14974 201 K--SSKPLRVLLAVVVA---FFLCWLPYHVFALLELVAAAGLPEVVLLGLPLAtglaYFNSCLNPILYVFMGQDFRKRL 274
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
29-329 9.92e-08

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 53.03  E-value: 9.92e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMvGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15089   3 ITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSAKYLMETWPFGELLCKAVLSIDYY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFlPLLLgwheLGHARPPVPGQCRLLASLP- 187
Cdd:cd15089  82 NMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGV-PIMV----MAVTKTPRDGAVVCMLQFPs 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 ------FVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASlttgmasqasetlqvprtprpgvESADSRRLATKHSR 261
Cdd:cd15089 157 pswywdTVTKICVFIFAFVVPILVITVCYGLMILRLRSVRLLS-----------------------GSKEKDRNLRRITR 213
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504545  262 KALkasltlgILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTW-----LGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15089 214 MVL-------VVVAAFIICWTPIHIFVIVWTLVDIDRRNPLVVAALhlciaLGYANSSLNPVLYAFLDENFKR 279
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
32-331 1.08e-07

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 53.30  E-value: 1.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   32 ALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCS 111
Cdd:cd15396   6 AYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMCKLTSFVQSVSVS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  112 ASILNLCLISLDRYLLILSPLRYKLRMTplRALALVLGAWSLAALASFlPLLLGWH----ELGHARPPV----------- 176
Cdd:cd15396  86 VSIFSLVLIAIERYQLIVNPRGWKPSAS--HAYWGIVLIWLFSLMISI-PFLIFHQltdePFRNLSSHSdfykdkvvcie 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  177 --PGQC-RLLASLPFVLvasgLTFFLPSGAICFTYCRILLAARKQavqvasltTGMASQASETlqvprtprpgvesaDSR 253
Cdd:cd15396 163 awPSETeRLIFTTSLLV----FQYFVPLGFIFICYLKIFVCLKKR--------NSKIDRMREN--------------ESR 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  254 RLATKhsrkalKASLTLGILLGMFFVTWLPFFVANIV-----QAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFK 328
Cdd:cd15396 217 LSENK------RINTMLISIVVTFAACWLPLNIFNVVfdwnhEVLMSCHHNLVFTLCHLVAMVSTCINPIFYGFLNKNFQ 290

                ...
gi 4504545  329 RAL 331
Cdd:cd15396 291 KDL 293
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
29-331 1.09e-07

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 53.28  E-value: 1.09e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALR--NTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFD 106
Cdd:cd14976   3 VSVVYMVVFTVGLLGNLLVLYLLKSNKKLRqqSESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYVT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  107 VMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASF-------LPLLLGWHELGHARPPVPGQ 179
Cdd:cd14976  83 KLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIpeaifstDTWSSVNHTLCLLRFPKNSS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  180 CRLLASL--PFVLVASGLTFFLPSGAICFTYCRILlaarkqavqvaslttgmasqasETLQvprtprpgvesadsRRLAT 257
Cdd:cd14976 163 VTRWYNWlgMYQLQKVVLGFFLPLGIITLSYLLLL----------------------RFLQ--------------RKRGG 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  258 KHSRKAlKASLTLGILLGMFFVTWLPFFVANIVQAVCD-----------CISPGLFDVLTWLGYCNSTMNPIIYPLFMRD 326
Cdd:cd14976 207 SKRRKS-RVTKSVFIVVLSFFICWLPNQALSLWSALIKfddvpfsdaffAFQTYAFPVAICLAHSNSCLNPVLYCLVRRE 285

                ....*
gi 4504545  327 FKRAL 331
Cdd:cd14976 286 FRDAL 290
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
35-329 1.09e-07

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 53.03  E-value: 1.09e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15125   9 LIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQLTSVGVSV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGwhELGHARP----------PVPGQCRLLA 184
Cdd:cd15125  89 FTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVFS--EVAHIMPddnttftaciPYPQTDEMHP 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  185 SLPFVLVAsgLTFFL-PSGAICFTYCRILLAARKQAVQVaslttgmasqasetlqvprtprPGVESADSRRlaTKHSRKA 263
Cdd:cd15125 167 KIHSVLIF--LVYFLiPLAIISIYYYHIAKTLIKSAHNI----------------------PGEYSEHSKR--QMETRKR 220
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4504545  264 LkASLTLgILLGMFFVTWLPFFVANIVQAV-CDCISPGLFDVLTW-----LGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15125 221 L-AKIVL-VFVGLFAFCWFPNHVLYMYRSFnYNEIDSSLGHMIVTlvarvLSFCNSCVNPFALYLLSESFRR 290
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
35-224 1.52e-07

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 52.70  E-value: 1.52e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWT---AFDVMCcs 111
Cdd:cd15168   9 VVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDHWIFGDFMCKLVRflfYFNLYG-- 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  112 aSILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLLGWHElghARPPVPGQCRLLAS------ 185
Cdd:cd15168  87 -SILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQL-LPILFFATT---GRKNNRTTCYDTTSpeelnd 161
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 4504545  186 -LPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVAS 224
Cdd:cd15168 162 yVIYSMVLTGLGFLLPLLIILACYGLIVRALIRKLGEGVT 201
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
29-223 1.88e-07

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 52.26  E-value: 1.88e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALR---NTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGR--WVLARGLCLLWT 103
Cdd:cd15130   3 VTAIYLALFVVGTVGNSVTLFTLARKKSLQslqSTVRYHLGSLALSDLLILLLAMPVELYNFIWVHhpWAFGDAGCRGYY 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  104 AFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWsLAALASFLPLLLGW---HELGHARPPVPGQC 180
Cdd:cd15130  83 FLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIW-LASALLAIPMLFTMglqNESDDGTHPGGLVC 161
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 4504545  181 RLLASLP----FVLVASGLTFFLPSGAICFTYCRI---LLAARKQAVQVA 223
Cdd:cd15130 162 TPIVDTAtlkvVIQVNTFMSFLFPMLVTSILNTVIankLVQALRRGVLVL 211
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
39-214 1.96e-07

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 52.23  E-value: 1.96e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLC 118
Cdd:cd15918  13 VTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDNFLLA 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPG-QCRLLASLPF--------- 188
Cdd:cd15918  93 VMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHfFCDLNPLLKLscsdthlne 172
                       170       180
                ....*....|....*....|....*...
gi 4504545  189 --VLVASGLTFFLPSGAICFTYCRILLA 214
Cdd:cd15918 173 lvILVLGGLVGLVPFLCILVSYVRIVSA 200
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
29-329 2.03e-07

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 52.18  E-value: 2.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALtaaANSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15092   6 VYLIVCVVGLV---GNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLPFQGTDIFLGFWPFGNALCKTVIAIDYY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELG--------------HARP 174
Cdd:cd15092  82 NMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEdeeieclveiptpqDYWD 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  175 PVPGQCRLLaslpfvlvasgLTFFLPSGAIcfTYCRILLAARKQAVQVASlttgmasqasetlqvprtprpgvESADSRR 254
Cdd:cd15092 162 PVFGICVFL-----------FSFIIPVLII--SVCYSLMIRRLRGVRLLS-----------------------GSKEKDR 205
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545  255 LATKHSRKALkasltlgILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVL----TWLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15092 206 NLRRITRLVL-------VVVAVFVGCWTPIQIFVLAQGLGVQPSSETAVAIlrfcTALGYVNSSLNPVLYAFLDENFKA 277
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
44-156 2.43e-07

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 51.88  E-value: 2.43e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLD 123
Cdd:cd15927  18 NGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFLKDTSIGVSVFTLTALSAD 97
                        90       100       110
                ....*....|....*....|....*....|...
gi 4504545  124 RYLLILSPLRYKLRMTPLRALALVLGAWSLAAL 156
Cdd:cd15927  98 RYFAIVNPMRKHRSQATRRTLVTAASIWIVSIL 130
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
43-164 2.65e-07

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 51.68  E-value: 2.65e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   43 ANSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYG-RWVLARGLCLLWTAFDVMCCSASILNLCLIS 121
Cdd:cd15162  17 ANGMALWVLLFRTKKKAPAVIYMANLAIADLLL-VIWLPFKIAYHIHGnNWIFGEALCRLVTVAFYGNMYCSILLLTCIS 95
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 4504545  122 LDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALAsFLPLLL 164
Cdd:cd15162  96 IDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLV-TLPLYL 137
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
34-219 4.62e-07

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 51.20  E-value: 4.62e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   34 CVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSAS 113
Cdd:cd15159   8 SLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPGRIAYYALGFDWPFGDWLCRLTALLFYINTYAG 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  114 ILNLCLISLDRYLLILSPLR-YKLRMTPlRALALVLGAWSLAALASfLPLLLgwhelghaRP---PVPGQ--CRLLAS-- 185
Cdd:cd15159  88 VNFMTCLSVDRYIAVVHPLRrHRLRKVK-VVRYICVFVWVLVFLQT-LPLLF--------MPmtkEMGGRitCMEYPNfe 157
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 4504545  186 ----LPFVL-VASGLTFFLPSGAICFTYCRILLAARKQA 219
Cdd:cd15159 158 kikrLPLILlGACVIGFGVPVGIILFCYSQITLKLCRTA 196
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
31-158 5.30e-07

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 50.89  E-value: 5.30e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCC 110
Cdd:cd15424   5 VVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLG 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 4504545  111 SASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALAS 158
Cdd:cd15424  85 STECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLS 132
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
44-151 5.47e-07

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 50.73  E-value: 5.47e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLD 123
Cdd:cd15231  18 NLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTECLLLAVMAYD 97
                        90       100
                ....*....|....*....|....*...
gi 4504545  124 RYLLILSPLRYKLRMTPLRALALVLGAW 151
Cdd:cd15231  98 RYVAICNPLHYAVIMSRKVCLQLAAASW 125
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
39-320 6.06e-07

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 50.91  E-value: 6.06e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYGR-WVLARGLCLLWTAFDVMCCSASILNL 117
Cdd:cd14991  13 LGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLL-LICLPFRIDYYLRGEhWIFGEAWCRVNLFMLSVNRSASIAFL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  118 CLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLLGWHELGHARPPVPGQCRLLASLPFVL----VAS 193
Cdd:cd14991  92 TAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLT-LPLLLSTLLTVNSNKSSCHSFSSYTKPSLSIrwhnALF 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  194 GLTFFLPSGAICFTYCRILLAARkqavqvaslttgmasqasetlqvprtprpgvesadsRRLATKHSRKALKASLTLGIL 273
Cdd:cd14991 171 LLEFFLPLGLIVFCSVRIACNLR------------------------------------IRQSLGKQARVQRAIRLVFLV 214
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  274 LGMFFVTWLPFFVA--------NIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIY 320
Cdd:cd14991 215 VIVFVLCFLPSIIAgllalvfkNLGSCRCLNSVAQLFHISLAFTYLNSALDPVIY 269
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
64-214 6.81e-07

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 50.72  E-value: 6.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   64 FLVSLFTSDLMVgLVVMPPAMLNALYG-RWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLR 142
Cdd:cd15170  39 LLLNLTVSDLIF-LLFLPFKMAEAASGmIWPLPYFLCPLSSFIFFSTIYISTLFLTAISVERYLGVAFPIKYKLRRRPLY 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  143 ALALVLGAWSLAALASFLPLLLGWHELGHARP-PVPGQC-------RLLASLPFVLVASGLTFFLPSGAICFTY---CRI 211
Cdd:cd15170 118 AVIASVFFWVLAFSHCSIVYIVEYHIDSENTSvTNNSRCydnftpeQLKILLPVRLELFLVLFCIPFLITCFCYinfIRI 197

                ...
gi 4504545  212 LLA 214
Cdd:cd15170 198 LSS 200
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
33-320 7.49e-07

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 50.57  E-value: 7.49e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTaaaNSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVM-------PPAMLNALYGrWVLARGLclLWTAF 105
Cdd:cd15342  10 VSVIVLLT---NLLVIAAIFINRRFHYPIYYLLGNLAAADLFAGVAYLflmfhtgPWTAKLSLYQ-WFLRQGL--LDTSL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  106 dvmccSASILNLCLISLDRYLLILSpLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWHELGHArppvpGQCRLLAS 185
Cdd:cd15342  84 -----TASVANLLAIAVERHQTIFT-MQLHSKMSNQRVVILIFGIWMVALILGLIP-AMGWNCLCDL-----KRCSTMAP 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 LpfvLVASGLTFFLPSGAICFT-----YCRILLAARKQAVQVASLTTgmasqasetlqvprtprpgvesadsrrLATKHS 260
Cdd:cd15342 152 L---YSRSYLVFWALSNLLTFLimvavYTRIFIYVRRKSQRMSEHHS---------------------------SHPRYR 201
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  261 RKALKASLTLGILLGMFFVTWLPFFVANIVQAVCdCISpglFDVLTW------LGYCNSTMNPIIY 320
Cdd:cd15342 202 ETVLGLMKTVVIILGAFVVCWTPGQVVLLLDGLG-CES---CNVLAYekyfllLAEINSLVNPIVY 263
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
33-329 7.77e-07

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 50.55  E-value: 7.77e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAA----NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLwTAFDVM 108
Cdd:cd15075   3 LSIIMAVFSIAsvvlNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNLGRVGCVL-EGFAVA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCS-ASILNLCLISLDRYLLILSPLRyKLRMTPLRALALVLGAWsLAALASFLPLLLGW--HELGHARPPVPG--QCRLL 183
Cdd:cd15075  82 FFGiAALCTVAVIAVDRLFVVCKPLG-TLTFQTRHALAGIASSW-LWSLIWNTPPLFGWgsYQLEGVMTSCAPdwYSRDP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  184 ASLPFVLVASGLTFFLPSGAICFTYCRILLAARkqavQVASLTTGMASqasetlqvprtprpgvesadsrrlATKHSrKA 263
Cdd:cd15075 160 VNVSYILCYFSFCFAIPFAIILVSYGYLLWTLR----QVAKLGVAEGG------------------------STAKA-EV 210
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504545  264 LKASLTLgILLGMFFVTWLPF--FVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15075 211 QVARMVV-VMVMAFLLCWLPYaaFALTVVSKPDVYINPLIATVPMYLAKSSTVYNPIIYIFMNKQFRD 277
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
35-158 8.40e-07

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 50.40  E-value: 8.40e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15408  22 LIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKVISFTGCLTQLYFYAVFATTEC 101
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALAS 158
Cdd:cd15408 102 YLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNS 145
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
29-164 8.44e-07

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 50.15  E-value: 8.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPalRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15368   5 VVYSLVALISIPGNLFSLWLLCFHTKP--KTPSIIFMINLSLTDLMLACFLPFQIVYHIQRNHWIFGKPLCNVVTVLFYA 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWsLAALASFLPLLL 164
Cdd:cd15368  83 NMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMW-LLVLTALSPLER 137
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
44-160 1.23e-06

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 49.61  E-value: 1.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTA-FDVMCCSASILnLCLISL 122
Cdd:cd15915  18 NGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHfFHFLGSSEAML-LAVMAY 96
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 4504545  123 DRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFL 160
Cdd:cd15915  97 DRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALM 134
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
92-158 2.27e-06

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 49.01  E-value: 2.27e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545   92 WVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALAS 158
Cdd:cd15120  65 WAFGTVLCKVLNSTLSVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLS 131
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
29-132 2.86e-06

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 48.74  E-value: 2.86e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15124   3 IPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQLT 82
                        90       100
                ....*....|....*....|....
gi 4504545  109 CCSASILNLCLISLDRYLLILSPL 132
Cdd:cd15124  83 SVGVSVFTLTALSADRYKAIVRPM 106
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
39-214 3.06e-06

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 48.61  E-value: 3.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLC 118
Cdd:cd15225  13 VTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTECFLLA 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFlplllgwhelgharppvpGQCRLLASLPF---------- 188
Cdd:cd15225  93 AMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSL------------------GQTTLIFSLPFcgsneinhff 154
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 4504545  189 --------------------VLVASGLTFFLPSGAICFTYCRILLA 214
Cdd:cd15225 155 cdippvlklacadtslneiaIFVASVLVILVPFLLILVSYIFIIST 200
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
33-331 3.63e-06

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 48.79  E-value: 3.63e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGR-WVLARGLCLLWTAFDVMCCS 111
Cdd:cd15217   7 LGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSaWTYSVLSCKIVAFMAVLFCF 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  112 ASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLL-LGWHELGHARPPVPGQCRLLA---SLP 187
Cdd:cd15217  87 HAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVFdVGTYKFIREEDQCIFEHRYFKandTLG 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 FVLVASGLTFflpsgAICFTYCRILLAARK----QAVQVASL-----------TTGMASqASETLQVPRTPRP----GVE 248
Cdd:cd15217 167 FMLMLAVLIV-----ATHIVYGKLLLFEYRhrkmKPVQMVPAisqnwtfhgpgATGQAA-ANWIAGFGRGPMPptllGIR 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  249 S---ADSRRLATKHSRKALK--ASLTLGILLgMFFVTWLPFFVANIVQA-VCDCISPGLF-DVLTWLGYCNSTMNPIIYP 321
Cdd:cd15217 241 QnahTANRRLLGMEEFKAEKrlGRMFYVITL-SFLVLWSPYIVACYWRVfVKACSIPHRYlSTAVWMSFAQAGVNPIVCF 319
                       330
                ....*....|
gi 4504545  322 LFMRDFKRAL 331
Cdd:cd15217 320 LLNKDLKKCL 329
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
29-329 3.66e-06

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 48.28  E-value: 3.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIA-LICTQPALRNTSNFFLVSLFTSDLMVGLVVMP-PAMLNALYGrWVLARGLCLLWTAFD 106
Cdd:cd15097   3 VPVVFSLIFLLGTVGNSLVLAvLLRSGQSGHNTTNLFILNLSVADLCFILFCVPfQATIYSLEG-WVFGSFLCKAVHFFI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  107 VMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFlPLL--LGWHELGHARPPVPG----QC 180
Cdd:cd15097  82 YLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAG-PYLsyYDLIDYANSTVCMPGweeaRR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  181 RLLASLPFVlvasgLTFFLPSGAICFTYCRillaarkqavqvaslttgmasqaseTLQVPRTPRPGVESADSRRLATkhs 260
Cdd:cd15097 161 KAMDTCTFA-----FGYLIPVLVVSLSYTR-------------------------TIKYLWTAVDPLEAMSESKRAK--- 207
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  261 RKALKASLTLGILlgmFFVTWLPFFVAnivqAVCDCISPGLFDVLTW--------LGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15097 208 RKVTKMIIIVTAL---FCLCWLPHHVV----ILCYLYGDFPFNQATYafrllshcMAYANSCLNPIVYALVSKHFRK 277
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
43-193 3.75e-06

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 48.31  E-value: 3.75e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   43 ANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRwVLARGLCLLWTAFDVMCCSASILNLCLISL 122
Cdd:cd15211  16 ANVLVIYLVVSFKKLQTTSNAFIVNGCVADLLVCAFWMPQEAVLGSTGT-LLVLGYRLFREGLLFLGLTVSLLSHSLIAL 94
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4504545  123 DRYLLIL-SPLRYKLRMTPLRALALVLGAWSLAALasFLPLLLGWHElghaRPPVPGQCRLLASLPFVLVAS 193
Cdd:cd15211  95 NRYVLITkLPAVYQALYQKRNTEWMIALSWALALG--LLLPWLTSFR----YPTKSCHDSADGSFAVVSVLS 160
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
35-151 3.94e-06

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 48.18  E-value: 3.94e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15415   9 LIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEG 88
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAW 151
Cdd:cd15415  89 FLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSY 125
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
32-212 4.29e-06

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 48.14  E-value: 4.29e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   32 ALCVVIAL-TAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCC 110
Cdd:cd15430   5 VLCLIMYLvILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  111 SASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWhelghaRPPVPGQ-------CRLL 183
Cdd:cd15430  85 STECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAM------QLPFCGNnvinhftCEIL 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 4504545  184 ASLP-----------FVLVASGLTFFLPSGAICFTYCRIL 212
Cdd:cd15430 159 AVLKlacvdislneiIMLVGNIIFLVIPLLLICISYIFIL 198
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
44-331 4.72e-06

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 47.86  E-value: 4.72e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVG------LVVMPPAMLNALYGRWVLARGLclLWTAFdvmccSASILNL 117
Cdd:cd15349  18 NLLVLLAILRRVRLRRWVYICLANIALSDLLTGtsylvnICLSGERTFRLTPALWFLREGL--LFTAL-----AASTFSL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  118 CLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWHELGHARppvpgQCRLLASLP------FVLV 191
Cdd:cd15349  91 LVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIGFLP-LLGWNCLCDFR-----SCSSLLPLYsksyilFCLV 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  192 ASGLTFFLPSGAICFTYCRILLAARKQAvqvaslttgmasqasetlqvprtprpgvesadsRRLATKHSRKALKASLtlg 271
Cdd:cd15349 165 IFFIILLTIIGLYFAIYCLVRASGQRVI---------------------------------SARSRRRSLRLLKTVL--- 208
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504545  272 ILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTW---LGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15349 209 MILGAFMVCWGPLFILLLVDFFCSSRSCKPLFGMEWvlaLAVLNSAINPLIYSFRSLEVRRAV 271
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
35-216 5.95e-06

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 47.76  E-value: 5.95e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYG-RWVLARGLCLLWTAFDVMCCSAS 113
Cdd:cd15160   9 FVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLY-ILTLPLWIDYTANHhNWTFGPLSCKVVGFFFYTNIYAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  114 ILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLllgWHELGHARPPVPGQC-------RLLASL 186
Cdd:cd15160  88 IGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFL---GHDELFRDEPNHTLCyekypmeGWQASY 164
                       170       180       190
                ....*....|....*....|....*....|
gi 4504545  187 PFVLVASGltFFLPSGAICFTYCRILLAAR 216
Cdd:cd15160 165 NYARFLVG--FLIPLSLILFFYRRVLRAVR 192
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
34-156 7.47e-06

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 47.52  E-value: 7.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   34 CVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLA-----RGLCLLWTAFDVM 108
Cdd:cd15128   8 CLIFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIDLPINVYKLLAMDWPFGdqpfgQFLCKLVPFIQKA 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAAL 156
Cdd:cd15128  88 SVGITVLNLCALSVDRYRAVASWSRIQGIGIPMWTAVEIVMIWMLSAV 135
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-156 9.70e-06

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 47.21  E-value: 9.70e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   34 CVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSAS 113
Cdd:cd15977   8 CVIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILIAIPINVIKLIAEDWPFGVHVCKLYPFIQKASVGIT 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 4504545  114 ILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAAL 156
Cdd:cd15977  88 VLSLCALSIDRYRAVASWSRIRGIGIPVWKAVEVTLIWAVAII 130
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
39-159 1.05e-05

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 46.67  E-value: 1.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLC 118
Cdd:cd15940  13 LTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIFLLT 92
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASF 159
Cdd:cd15940  93 IMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSL 133
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
35-135 1.12e-05

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 46.84  E-value: 1.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15123   9 VIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQLTSVGVSV 88
                        90       100
                ....*....|....*....|.
gi 4504545  115 LNLCLISLDRYLLILSPLRYK 135
Cdd:cd15123  89 FTLTVLSADRYRAIVKPLELQ 109
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
31-160 1.41e-05

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 46.29  E-value: 1.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTA-AANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMC 109
Cdd:cd15227   4 FVLFLLIYLAAlTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 4504545  110 CSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFL 160
Cdd:cd15227  84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGAL 134
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
31-153 1.52e-05

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 46.27  E-value: 1.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAAANSLLIALICTQPALRNTSN-FFLVSLFTSDLmVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMC 109
Cdd:cd14983   5 MVYVLTILLGLPSNLLALYAFVNRARLRLTPNvIYMINLCLSDL-VFILSLPIKIVEALSSAWTLPAVLCPLYNLAHFST 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 4504545  110 CSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSL 153
Cdd:cd14983  84 LYASTCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWAL 127
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
28-331 1.61e-05

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 46.24  E-value: 1.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDV 107
Cdd:cd15114   1 VVALVLYAVVFLVGVPGNALVAWVTGFEAKRSVNAVWFLNLAVADLLCCLSLPILAVPIAQDGHWPFGAAACKLLPSLIL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAalasflplllgwhelgharppvpgqcrLLASLP 187
Cdd:cd15114  81 LNMYASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLA---------------------------LLLTVP 133
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 FVLVASGLTFFLPSGAICFTYCRILlAARKQAVQVASLTTGMAsqasetlqvprTPRPGVESADSRRLATKHSRKALKAS 267
Cdd:cd15114 134 SFIYRRIHQEHFPEKTVCVVDYGGS-TGVEWAVAIIRFLLGFL-----------GPLVVIASCHGVLLVRTWSRRRQKSR 201
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504545  268 LTLGILLGM---FFVTWLPFFVANIVQAVCDCISPGLFDVL------TWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15114 202 RTLKVVTAVvvgFFLCWTPYHVVGLIIAASAPNSRLLANALkadpltVSLAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
44-226 1.86e-05

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 46.30  E-value: 1.86e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMvgLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLD 123
Cdd:cd15923  18 NILALWVFCWRLKKWTETNIYMTNLAVADLL--LLISLPFKMHSYRRESAGLQKLCNFVLSLYYINMYVSIFTITAISVD 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  124 RYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLG-WHELGHARPPVPGQCRLLASLPFVLVAsgltFFLPSG 202
Cdd:cd15923  96 RYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIPYFLLDsSNEKTMCFQRTKQTESLKVFLLLEIFG----FLLPLI 171
                       170       180
                ....*....|....*....|....*.
gi 4504545  203 AICFTYCRIL--LAARKQAVQVASLT 226
Cdd:cd15923 172 IMTFCSARVIhtLQKRLDDVGSRSET 197
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
35-151 2.33e-05

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 45.76  E-value: 2.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15419   9 VIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEG 88
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAW 151
Cdd:cd15419  89 FLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSY 125
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
28-164 2.34e-05

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 45.95  E-value: 2.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPpAMLNALygrWVLARGL----CLLWT 103
Cdd:cd15222   2 WISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLP-TVLGIF---WFNAREIsfdaCLAQM 77
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  104 ----AFDVMccSASILnlCLISLDRYLLILSPLRYKLRMTPLRALALVLGAwSLAALASFLPLLL 164
Cdd:cd15222  78 ffihTFSFM--ESSVL--LAMAFDRFVAICNPLRYASILTNSRIAKIGLAI-VLRSVLLLLPLPF 137
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
35-160 2.67e-05

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 45.73  E-value: 2.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15410  22 AIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKAISYSGCMLQFFFFCTFVVTES 101
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFL 160
Cdd:cd15410 102 FLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLI 147
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
35-167 2.87e-05

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 45.50  E-value: 2.87e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWT-AFDVMCCSAS 113
Cdd:cd15942   9 VVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLfFFHFLGCAEC 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 4504545  114 ILnLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWH 167
Cdd:cd15942  89 FL-YTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFR 141
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
36-331 2.89e-05

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 45.58  E-value: 2.89e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   36 VIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDlMVGLVVMPPAMLN-ALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15339   9 ILCSTGLVGNILVLFTIIRSRKKTVPDIYVCNLAVAD-LVHIIVMPFLIHQwARGGEWVFGSPLCTIITSLDTCNQFACS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWslaaLASFLPLLLGWHelgHARPPVPGQ----CRLLASLP--- 187
Cdd:cd15339  88 AIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVW----AASFILVLPVWV---YAKVIKFRDglesCAFNLTSPddv 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 --FVLVASGLTFFLPSGAICFTYCRILlaarkqavqvaslttgmaSQASETLQVPRTPRPGVESADSRRlatkhsrkALK 265
Cdd:cd15339 161 lwYTLYQTITTFFFPLPLILICYILIL------------------CYTWEMYRKNKKAGRYNTSIPRQR--------VMR 214
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  266 ASLTLGILLGMFFVTWLPFFVANIVQAVCDciSPGLFDVLTW-----LGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15339 215 LTKMVLVLVGVFLVSAAPYHVIQLVNLSVS--QPTLAFYVSYylsicLSYASSSINPFLYILLSGNFRKRL 283
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
39-164 3.31e-05

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 45.17  E-value: 3.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSL------FTSDLMvglvvmpPAML-NALYGRWVLARGLCLL-WTAFDVMCC 110
Cdd:cd15911  13 VTMAGNILIIVLVVADRHLHTPMYFFLGNLscleicYTSTIL-------PRMLaSLLTGDRTISVSGCIVqFYFFGSLAA 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 4504545  111 SASILnLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLL 164
Cdd:cd15911  86 TECYL-LAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVIL 138
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
34-169 3.56e-05

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 45.18  E-value: 3.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   34 CVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMvgLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSAS 113
Cdd:cd15187   8 CLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLL--FVFSLPFQAYYLLDQWVFGNAMCKIVSGAYYIGFYSS 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  114 ILNLCLISLDRYLLILSPLrYKLRMTPLR-ALALVLGAWSLAALASfLPLLLGWHEL 169
Cdd:cd15187  86 MFFITLMSIDRYLAIVHAV-YALKVRTAShGTILSLALWLVAILAS-VPLLVFYQVA 140
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
40-156 3.92e-05

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 45.05  E-value: 3.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   40 TAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCL 119
Cdd:cd15406  23 TVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVFAIAECYMLTA 102
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 4504545  120 ISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAAL 156
Cdd:cd15406 103 MAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLI 139
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
33-320 3.98e-05

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 45.20  E-value: 3.98e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALtaaANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVM------PPAMLNALYGRWVLARGLclLWTAFd 106
Cdd:cd15101  10 VCIFIML---ANLLVIAAIYKNRRFHFPIYYLLANLAAADFFAGLAYFflmfntGPNTRRLTVSTWFLRQGL--LDTSL- 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  107 vmccSASILNLCLISLDRYLLILSpLRYKLRMTPLRALALVLGAWSLAALASFLPLLlGWHELGHARppvpgQCRLLASL 186
Cdd:cd15101  84 ----TASVANLLAIAVERHISVMR-MQLHSRLSNRRVVVLIVLVWTMAIVMGAIPSV-GWNCLCAID-----ACSNMAPL 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  187 pfvLVASGLTFFLPSGAICFTYCRILLAarKQAVQVASLTTGMASQASETLQVPRTPrpgvesadsrrlatkhsrkaLKA 266
Cdd:cd15101 153 ---YSRSYLVFWAISNLVTFLVMVVVYA--RIFVYVRRRTNRMSPHTSGSIRNRDTM--------------------MSL 207
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  267 SLTLGILLGMFFVTWLPFFVANIVQAVCdCISPGLFDVLTW---LGYCNSTMNPIIY 320
Cdd:cd15101 208 LKTVVIVLGAFVVCWTPGLVVLLLDGLC-CRQCNVLAVEKFfllLAEFNSAVNPIIY 263
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
35-212 3.99e-05

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 45.21  E-value: 3.99e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMvgLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15186   9 LVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLL--FVATLPFWTHYLINEWGLHNAMCKLTTAFFFIGFFGGI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASG 194
Cdd:cd15186  87 FFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMFTKMKENECLGDYPEVLQEIWPVLRNVELNF 166
                       170
                ....*....|....*...
gi 4504545  195 LTFFLPSGAICFTYCRIL 212
Cdd:cd15186 167 LGFLLPLLIMSYCYFRII 184
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
63-331 4.06e-05

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 45.25  E-value: 4.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   63 FFLVSLFTSDLMVGLVVMPPAMLNALY------GRWVLARGLCLLwtafdvmCCSASILNLCLISLDRYLLILSpLRYKL 136
Cdd:cd15346  37 YFIGNLALSDLLAGVAYTANLLLSGATtykltpTQWFLREGSMFV-------ALSASVFSLLAIAIERYITMLK-MKLHN 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  137 RMTPLRALALVLGAWSLAALASFLPlLLGWHELGHARppvpgQCRLLASL---PFVLVASGLtFFLPSGAICFTYCRILL 213
Cdd:cd15346 109 GSNSFRSFLLISACWVISLILGGLP-IMGWNCISALS-----SCSTVLPLyhkHYILFCTTV-FTLLLLSIVILYCRIYS 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  214 AARKQAVQVASLTTGmasqasetlqvprtprpgvesadsrRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAV 293
Cdd:cd15346 182 LVRTRSRRLTFRKNI-------------------------RKASRSSEKSMALLKTVIIVLSVFIACWAPLFILLLLDVG 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 4504545  294 CDCISPGLFDVLTW---LGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15346 237 CKVKTCSILFKAEYflvLAVLNSATNPIIYTLTNKEMRRAF 277
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
29-331 4.54e-05

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 44.86  E-value: 4.54e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNT-SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDV 107
Cdd:cd15925   3 VALAYGLVCAIGLLGNLAVMYLLRNCARRAPPpIDVFVFNLALADFGFALTLPFWAVESALDFHWPFGGAMCKMVLTATV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGwhelghARPPVPGQCRLLASLP 187
Cdd:cd15925  83 LNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFA------TEGEVCGVELCLLKFP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  188 -------FVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVaslttgmasqasetlqvpRTPRpgvesaDSRRLATkhs 260
Cdd:cd15925 157 snywlgaYHLQRVVVAFVVPLGVITTSYLLLLSFLQQHKVNQ------------------NNRQ------RQSVIAR--- 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  261 rkalkaslTLGILLGMFFVTWLPFFVANIVQAVCD-----------CISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKR 329
Cdd:cd15925 210 --------SVRLVVASFFLCWFPNHVVTFWGVLVKfravpwnstfyFIHTYVFPVTTCLAHSNSCLNPVLYCLMRREFRQ 281

                ..
gi 4504545  330 AL 331
Cdd:cd15925 282 AL 283
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
57-331 4.56e-05

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 45.13  E-value: 4.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   57 LRNTSNF--FLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRY 134
Cdd:cd15924  28 IPSKSSFiiYLKNTVVADLLMILTFPFKILSDAGLGPWQLRTFVCRVTSVLFYFTMYTSIVFLGLISIDRYLKIVRPFKT 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  135 KLRMTPLRALALVLGAWSLAALASFLPLLLgwhELGHARPPVPGQCRLLASlPFvlvasGLTFFLPSGAICftycrilla 214
Cdd:cd15924 108 SFPKSVSFAKILSVVVWALMFLLSLPNMIL---TNQQPREKNVKKCSFLKS-EL-----GLKWHEIVNYIC--------- 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  215 arkQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRlaTKHSRKALkasltlgILLGMFFVTWLPFFVANI----- 289
Cdd:cd15924 170 ---QVIFWIVFLLMIVCYTAITKKVYRSYRRVFRSSSSRR--KKSNVKIF-------IIVAVFFVCFVPYHFARIpytls 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 4504545  290 -VQAVCDCISPG-LF---DVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15924 238 qTRDVFDCTAENiLFyvkEATLFLSALNVCLDPIIYFFLCKSFRESL 284
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
39-163 4.67e-05

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 44.89  E-value: 4.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLC 118
Cdd:cd15229  13 LTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFLLS 92
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASF---LPLL 163
Cdd:cd15229  93 AMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALintLLLL 140
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
35-158 6.36e-05

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 44.39  E-value: 6.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15428   9 IIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITEC 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALAS 158
Cdd:cd15428  89 ALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVS 132
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
39-164 6.44e-05

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 44.58  E-value: 6.44e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDV-MCCSASILnL 117
Cdd:cd15224  13 LTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLsLACTECVL-L 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 4504545  118 CLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLL 164
Cdd:cd15224  92 AVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYF 138
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
31-338 7.26e-05

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 44.40  E-value: 7.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCC 110
Cdd:cd15386   5 GVLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFQVLPQLIWEITYRFQGPDLLCRAVKYLQVLSM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  111 SASILNLCLISLDRYLLILSPLRyKLRMTPLRALALVLGAWSLAALASfLPLLlgwhelgharppvpgqcrLLASLPFVL 190
Cdd:cd15386  85 FASTYMLIMMTVDRYIAVCHPLR-TLQQPSRQAYLMIGATWLLSCILS-LPQV------------------FIFSLREVD 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  191 VASGL-----TFFLPSGA---ICFTYCRILLAARKQAVQVASLTT-------GMASQASETLQVPRTPRPGVESADSRRL 255
Cdd:cd15386 145 QGSGVldcwaDFGFPWGAkayITWTTLSIFVLPVAILIVCYSLICyeicknlKGKTQTSRSEGGGWRTQGMPSRVSSVRT 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  256 ATKHSRKALKasLTLGILLGmFFVTWLPFFVANIvQAVCDCISPG------LFDVLTWLGYCNSTMNPIIYPLFMrdfkr 329
Cdd:cd15386 225 ISRAKIRTVK--MTFVIVLA-YIACWAPFFSVQM-WSVWDENAPDedssdfAFTITMLLASLSSCCNPWIYMFFS----- 295

                ....*....
gi 4504545  330 alGRFLPCP 338
Cdd:cd15386 296 --GHLLQDV 302
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
33-151 9.25e-05

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 43.90  E-value: 9.25e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSA 112
Cdd:cd15914   7 LLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLGIT 86
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 4504545  113 SILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAW 151
Cdd:cd15914  87 ECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCW 125
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
36-151 9.87e-05

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 43.86  E-value: 9.87e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   36 VIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASIL 115
Cdd:cd15936  10 VYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEVF 89
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 4504545  116 NLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAW 151
Cdd:cd15936  90 LLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSW 125
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-135 1.04e-04

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 44.07  E-value: 1.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   34 CVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSAS 113
Cdd:cd15976   8 CLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGIT 87
                        90       100
                ....*....|....*....|..
gi 4504545  114 ILNLCLISLDRYLLILSPLRYK 135
Cdd:cd15976  88 VLSLCALSIDRYRAVASWSRIK 109
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
39-160 1.06e-04

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 43.96  E-value: 1.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLC 118
Cdd:cd15945  26 LTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSIPFYGCALQMFFFAAFADAECLLLA 105
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFL 160
Cdd:cd15945 106 VMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLV 147
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
87-331 1.08e-04

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 43.95  E-value: 1.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   87 ALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGW 166
Cdd:cd15117  60 ALGFHWPFGWFLCKLYSTLVVFNLFASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVFRD 139
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  167 HELGHARPPV------PGQCRLLASLPFVLVASGLT----------FFLPSGAICFtyCRILLAARKQAVQVAslttgma 230
Cdd:cd15117 140 TRKENGCTHCylnfdpWNETAEDPVLWLETVVQRLSaqvitrfvlgFLVPLVIIGG--CYGLIAARLWREGWV------- 210
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  231 sqasetlqvprtprpgvesadsrrlatkHSRKALKaslTLGILLGMFFVTWLPFFVANIVQ-AVCDCISPGLFDVLTW-- 307
Cdd:cd15117 211 ----------------------------HSSRPFR---VLTAVVAAFFLCWFPFHLVSLLElVVILNQKEDLNPLLILll 259
                       250       260
                ....*....|....*....|....*....
gi 4504545  308 -----LGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15117 260 plsssLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
32-329 1.18e-04

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 43.87  E-value: 1.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   32 ALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGR-WVLARGLCLLWTAFDVMCC 110
Cdd:cd15218   6 SLGFIIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFTSVKNGStWTYGTLTCKVIAFLGVLSC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  111 SASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLL-LGWHELGHARPPVPGQCR-------- 181
Cdd:cd15218  86 FHTAFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLdVGTYSFIREEDQCTFQHRsfrandsl 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  182 -LLASLPFVLVASGLTFFlpsGAICFTYCRILLAARKQAVQVASLTT----GMASQASETL-----QVPRTP-----RPG 246
Cdd:cd15218 166 gFMLLLALILLATQLVYL---KLIFFVHDRRKMKPVQFVAAVSQNWTfhgpGASGQAAANWlagfgRGPTPPtllgiRQN 242
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  247 VESADSRRLATKHSRKALK-ASLTLGILLGMFFVTWLPFFVANI--VQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLF 323
Cdd:cd15218 243 ANTTGRRRLLVLDEFKMEKrISRMFYIMTFLFLTLWGPYLVACYwrVFARGPVVPGGFLTAAVWMSFAQAGINPFVCIFS 322

                ....*.
gi 4504545  324 MRDFKR 329
Cdd:cd15218 323 NRELRR 328
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
34-154 1.36e-04

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 43.70  E-value: 1.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   34 CVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARG-----LCLLWTAFDVM 108
Cdd:cd15975   8 CIIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIDIPINVYKLLAQKWPFDDSsfgvfLCKLVPFLQKA 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLA 154
Cdd:cd15975  88 SVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIFSIWVLS 133
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
35-213 1.36e-04

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 43.61  E-value: 1.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLvVMPPAMLN-ALYGRWVLARGLCLLWTAFDVMCCSAS 113
Cdd:cd15968   9 FVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYAL-SLPLLIYNyAMRDRWLFGDFMCRLVRFLFYFNLYGS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  114 ILNLCLISLDRYLLILSPLRyKLRMTPLRALALVLGAWSLAALASFLPLLLgwhelgHARPPVPGQ---CRLLAS----- 185
Cdd:cd15968  88 ILFLTCISVHRYLGICHPMR-PWHKETRRAAWLTCVLVWILVFAQTLPILI------FARTGIIRNrtvCYDLAPpalfp 160
                       170       180       190
                ....*....|....*....|....*....|
gi 4504545  186 --LPFVLVASGLTFFLPSGAICFTYCRILL 213
Cdd:cd15968 161 hyVPYGMALTVSGFLLPFSIILWCYCLVVR 190
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
29-331 1.39e-04

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 43.55  E-value: 1.39e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTS---NFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAF 105
Cdd:cd15002   1 LVPILLGVICLLGFAGNLMVIGILLNNARKGKPsliDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  106 DVMCCSASILNLCLISLDRYLLILSPLRyKLRMTPLRALALVLGAWSLA---ALASFLPLLLGWHE---LGHARPPVPGQ 179
Cdd:cd15002  81 GHACMAAKSFTIAVLAKACYMYVVNPTK-QVTIKQRRITAVVASIWVPAcllPLPQWLFRTVKQSEgvyLCILCIPPLAH 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  180 CRLLAslpFVLVASGLTFFLPSGAICFTYCRILLAARKqavqvasltTGMASQASETlqvprtprpgveSADSRRLatkh 259
Cdd:cd15002 160 EFMSA---FVKLYPLFVFCLPLTFALFYFWRAYGQCQR---------RGTKTQNLRN------------QIRSRKL---- 211
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  260 srkalkaSLTLGILLGMFFVTWLP---FFVANIVQAVCDCISPGLFDVLT-WLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15002 212 -------THMLLSVVLAFTILWLPewvAWLWLIHIKSSGSSPPQLFNVLAqLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
38-160 1.66e-04

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 43.27  E-value: 1.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   38 ALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNL 117
Cdd:cd15230  12 LITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECFLL 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 4504545  118 CLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFL 160
Cdd:cd15230  92 AAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIV 134
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
36-216 1.81e-04

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 43.23  E-value: 1.81e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   36 VIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVmpPAMLNALYGR--WVLARGLCLLWTAFDVMCCSAS 113
Cdd:cd15365  10 VIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVIL--PLWIDYLWNGdnWTLSGFVCIFSAFLLYTNFYTS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  114 ILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALasFLPLLLGWHELGHAR----------PPVPGQCRll 183
Cdd:cd15365  88 TALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEIC--FNAVILTWEDSFHESsshtlcydkfPLEDWQAR-- 163
                       170       180       190
                ....*....|....*....|....*....|...
gi 4504545  184 aslpFVLVASGLTFFLPSGAICFTYCRILLAAR 216
Cdd:cd15365 164 ----LNLFRICLGYLLPLLIILFCYWKIYQAVR 192
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
35-214 1.90e-04

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 43.08  E-value: 1.90e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15420   9 LLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWhelghaRPPVPGQ-------CRLLASLP 187
Cdd:cd15420  89 VLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLL------RLPFCGPnevnhffCEILAVLK 162
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 4504545  188 F---------VLVASGLTFFL--PSGAICFTYCRILLA 214
Cdd:cd15420 163 LacadtwineILIFAGCVFILlgPFSLILISYLHILAA 200
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
44-163 1.99e-04

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 43.00  E-value: 1.99e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNF--FLVSLFTSDLmVGLVVMPPAMLnALY---GRWVLARGLCLlWTAFDVMCCS-ASILNL 117
Cdd:cd14981  18 NLLALIVLARSSKSHKWSVFyrLVAGLAITDL-LGILLTSPVVL-AVYasnFEWDGGQPLCD-YFGFMMSFFGlSSLLIV 94
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 4504545  118 CLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLL 163
Cdd:cd14981  95 CAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPLL 140
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
36-221 2.32e-04

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 42.97  E-value: 2.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   36 VIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLwTAFDVMCCSASIL 115
Cdd:cd15081  22 VVFASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVL-EGFTVSVCGITGL 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  116 -NLCLISLDRYLLILSPLRyKLRMTPLRALALVLGAWSLAALASFLPlLLGW-----HELGHA-RPPVPGQCRLLASLPF 188
Cdd:cd15081 101 wSLTIISWERWVVVCKPFG-NIKFDGKLAIVGIIFSWVWSAVWCAPP-IFGWsrywpHGLKTScGPDVFSGSSDPGVQSY 178
                       170       180       190
                ....*....|....*....|....*....|...
gi 4504545  189 VLVASGLTFFLPSGAICFTYCRILLAARKQAVQ 221
Cdd:cd15081 179 MIVLMITCCIIPLAIIILCYLQVWLAIRAVAQQ 211
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
33-328 2.45e-04

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 42.45  E-value: 2.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   33 LCVVIALTAAANSLLIaLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSA 112
Cdd:cd15115   7 LSLTFLLGVPGNGLVI-WVAGLKMKRTVNTIWFLNLAVADLLCCLSLPFSIAHLLLNGHWPYGRFLCKLLPSIIVLNMFA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  113 SILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLPLLL---GWHELGHARppvpgqCRLLASLPFV 189
Cdd:cd15115  86 SVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLC-LPVFIyrtTVTDGNHTR------CGYDFLVAIT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  190 LVASGLTFFLPSGAICFTYCRIllAARKQAVQVAslttgmasqasetlqvprtprpgvesadsrrlatKHSRKALKASLt 269
Cdd:cd15115 159 ITRAVFGFLLPLLIIAACYSFI--AFRMQRGRFA----------------------------------KSQSKTFRVII- 201
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  270 lgILLGMFFVTWLPFFVANIVQAVCDCISPGLfdVLTW------LGYCNSTMNPIIYPLFMRDFK 328
Cdd:cd15115 202 --AVVVAFFVCWAPYHIIGILSLYGDPPLSKV--LMSWdhlsiaLAYANSCLNPVLYVFMGKDFK 262
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
35-331 2.67e-04

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 42.55  E-value: 2.67e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLmVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15183   9 LVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDL-VFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGLYSEI 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  115 LNLCLISLDRYLLILSPLryklrmTPLRALALVLG------AWSLAALASFLPLLL---GWHELGHA-RPPVPGQCRLLA 184
Cdd:cd15183  88 FFIILLTIDRYLAIVHAV------FALRARTVTFGiitsiiTWALAILASMPCLYFfksQWEFTHHTcSAHFPRKSLIRW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  185 SLPFVLVASGLTFFLPSGAICFTYCRILlaarkqavqvaslttgmasqasetlqvprtprpgvesadsRRLATKHSRKAL 264
Cdd:cd15183 162 KRFQALKLNLLGLILPLLVMIICYTGII----------------------------------------NILLRRPNEKKA 201
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504545  265 KASLTLGILLGMFFVTWLPFFVANIVQAVCD------CISPGLFD----VLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15183 202 KAVRLIFVITLLFFLLWTPYNLAAFVSAFQDvlftpsCEQSQQLDlalqVTEVIAYTHCCVNPVIYVFVGERFRKYL 278
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
63-329 3.08e-04

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 42.49  E-value: 3.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   63 FFLVSLFTSDLMVGLVVMPPAMLNALYG------RWVLARGlcllwTAFDVMCcsASILNLCLISLDRYLLILSPLRYKL 136
Cdd:cd15347  37 FFIGNLAFSDLLAGVAFIANILLSGSVTfrltpvQWFIREG-----TAFITLS--ASVFSLLAIAIERHVAITKVKLYGS 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  137 RMTpLRALALVLGAWSLAALASFLPlLLGWHELGHARppvpgQCR----LLASLPFVLVASGLTFFLPSgaICFTYCRIL 212
Cdd:cd15347 110 DKN-CRMVLLIGACWVISIVLGGLP-ILGWNCIGNLE-----DCStvlpLYSKHYILFVVTIFSIILLS--IVILYVRIY 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  213 LAARKQAVQVAslttgmasqASETLQVPRtprpgvesadsrrlatkhsrkalkaslTLGILLGMFFVTWLPFFVANIVQA 292
Cdd:cd15347 181 CIVRSSHAEMA---------APQTLALLK---------------------------TVTIVLGVFIVCWLPAFIILLLDT 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 4504545  293 VCDCIS-PGLFDVLTWLGYC--NSTMNPIIYPLFMRDFKR 329
Cdd:cd15347 225 SCKVKScPILYKADYFFSVAtlNSALNPVIYTLRSKDMRK 264
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
26-164 3.30e-04

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 42.46  E-value: 3.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545    26 SGWVAAALCVVIALTAAANsLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYGRWVLARGLCLLWTAF 105
Cdd:PHA03087  40 STILIVVYSTIFFFGLVGN-IIVIYVLTKTKIKTPMDIYLLNLAVSDLLF-VMTLPFQIYYYILFQWSFGEFACKIVSGL 117
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 4504545   106 DVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFlPLLL 164
Cdd:PHA03087 118 YYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETT-PILF 175
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
31-320 3.44e-04

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 42.11  E-value: 3.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVmpPAMLNALYGR-WVLARGLCLLWTAFDVMC 109
Cdd:cd15121   5 AILSLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTA--PFFLHFLSGGgWEFGSVVCKLCHYVCGVS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  110 CSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALAS----FLPLLLGW---HELGHARPPVPGQcrl 182
Cdd:cd15121  83 MYASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSlpmpFYRTVLKKninMKLCIPYHPSVGH--- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  183 lasLPFVLVASGLT-FFLPSGAICFTYCRILlaarkqavqvaslttgmasqasetlqvprtprpgvesadsRRLATKHSR 261
Cdd:cd15121 160 ---EAFQYLFETITgFLLPFTAIVTCYSTIG----------------------------------------RRLRSARFR 196
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  262 KALKASLTLGILLGMFFVTWLPFFVANIVQ---AVCDCISPGLF--------DVLTWLGYCNSTMNPIIY 320
Cdd:cd15121 197 RKRRTNRLVVLIIATFALFWLPYHVVNLIQvagALQNQAGNASVlkaaklarPNVTALAFLSSSVNPVLY 266
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
28-163 3.46e-04

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 42.28  E-value: 3.46e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDV 107
Cdd:cd15221   2 WISIPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVH 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLRYKLRMTP--LRALALVLGAWSLAALASFLPLL 163
Cdd:cd15221  82 FVFVTESAILLAMAFDRYVAICYPLRYTTILTHsvIGKIGVAAVARSFCIVFPFVFLL 139
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
35-160 3.90e-04

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 41.92  E-value: 3.90e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15413   9 VIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISEL 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFL 160
Cdd:cd15413  89 FLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALF 134
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
47-151 4.06e-04

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 41.97  E-value: 4.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   47 LIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYL 126
Cdd:cd15943  35 MIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKTISFTGCAAQMYFFVAFATTECFLLAVMAYDRYV 114
                        90       100
                ....*....|....*....|....*
gi 4504545  127 LILSPLRYKLRMTPLRALALVLGAW 151
Cdd:cd15943 115 AICNPLLYTVIMSPRVCIQLVAGSY 139
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
39-217 4.23e-04

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 42.08  E-value: 4.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLC 118
Cdd:cd15432  13 LTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGSTECVLLA 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAW----SLAALASFLPLLL---GWHELGHARPPVPGQCRL-----LASL 186
Cdd:cd15432  93 VMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWisgfANSLVQSTLTLKMprcGRRRVDHFFCEVPALLKLscvdtTANE 172
                       170       180       190
                ....*....|....*....|....*....|.
gi 4504545  187 PFVLVASGLTFFLPSGAICFTYCRILLAARK 217
Cdd:cd15432 173 AELFVISVLLLLIPLGLILISYIFIVRAVLR 203
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
28-216 4.32e-04

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 41.82  E-value: 4.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVG-----LVVMPPAMLNALYG---RWVLARGlC 99
Cdd:cd15136   2 WLRIGVWFVFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGiylglLAIVDAKTLGEYYNyaiDWQTGAG-C 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  100 LLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLlgwHELGHARPPV--P 177
Cdd:cd15136  81 KTAGFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLV---GVSSYSKTSIclP 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 4504545  178 GQCRLLASLPFV---LVASGLTFFLpsgaICFTYCRILLAAR 216
Cdd:cd15136 158 FETETPVSKAYViflLLFNGLAFLI----ICGCYIKIYLSVR 195
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
29-331 4.70e-04

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 41.74  E-value: 4.70e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15080   3 LAAYMFLLILLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFATL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRyKLRMTPLRALALVLGAWsLAALASFLPLLLGWHELgharPPVPGQCRL------ 182
Cdd:cd15080  83 GGEIALWSLVVLAIERYVVVCKPMS-NFRFGENHAIMGVAFTW-VMALACAAPPLVGWSRY----IPEGMQCSCgidyyt 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  183 ----LASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQvaslttgmaSQASETLQvprtprpgvesadsrrlatk 258
Cdd:cd15080 157 lkpeVNNESFVIYMFVVHFTIPLIVIFFCYGRLVCTVKEAAAQ---------QQESATTQ-------------------- 207
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  259 hsrKALKASLTLGILLGMFF-VTWLPF--FVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15080 208 ---KAEKEVTRMVIIMVIAFlICWVPYasVAFYIFTHQGSDFGPIFMTIPAFFAKSSAVYNPVIYILMNKQFRNCM 280
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
64-221 4.84e-04

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 41.67  E-value: 4.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   64 FLVSLFTSDLMVGLVvMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRA 143
Cdd:cd15154  38 YMCNLALSDLLFTLS-LPLRIYYYANHYWPFGNFLCQFSGSIFQMNMYGSCLFLMCINVDRYLAIVHPLRFRHLRRPKVA 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  144 LALVLGAWSLAALASFLPLLLgwHELGHARPPVPGQCRLLAS---------LPFVLVASGLTFFLPSGAICFTYCRILLA 214
Cdd:cd15154 117 RLLCLAVWALILGGSVPAAIV--HSSSDCLLHGEKVYRCFESfsdndwkglLPLVVLAEILGFLLPLAAVLYCSCRIFVE 194

                ....*...
gi 4504545  215 -ARKQAVQ 221
Cdd:cd15154 195 lCRTQEPQ 202
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
36-330 5.08e-04

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 41.64  E-value: 5.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   36 VIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASIL 115
Cdd:cd15000   9 VVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLASVL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  116 NLCLISLDRYLLILSPLRYKLRMtplRALALVLGAWSLAALASFLPLL----------LGWHELGHARppvpgQCRLLAS 185
Cdd:cd15000  89 ALCAVSYDRLTAIVLPSEARLTK---RGAKIVIVITWIVGLLLALPLAiyrsyrerqwKNFLETYCAE-----NTQVLPI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  186 LPFVLVasGLTFFLPSGAICFTYCRILLAARKQavqvaslttgmasqasetlqvprtprpgvESADSRRLATKHSRKALK 265
Cdd:cd15000 161 YWHVII--TVLVWLPLGIMLICYSAIFWKLDKY-----------------------------ERRVLRREHPSVVRYKKK 209
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4504545  266 ASLTLGILLGMFFVTWLPF----FVANIVQA--VCDCISPGLFDVL----TWLGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15000 210 AAKTLFIVLITFVVCRIPFtaliFYRYKLVPndNTQNSVSGSFHILwfasKYLMFLNAAVNPLIYGFTNENFRKA 284
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
28-148 5.70e-04

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 41.51  E-value: 5.70e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFD- 106
Cdd:cd15223   2 WLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIh 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 4504545  107 -VMCCSASILnLCLiSLDRYLLILSPLRYKLRMTPLRALALVL 148
Cdd:cd15223  82 fFTAMESSIL-LVM-ALDRYVAICKPLRYPSIITKSFILKLVL 122
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
40-164 6.12e-04

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 41.29  E-value: 6.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   40 TAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCL 119
Cdd:cd15236  14 TVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSFLLAV 93
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 4504545  120 ISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLL 164
Cdd:cd15236  94 MAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLL 138
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
34-152 7.67e-04

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 41.29  E-value: 7.67e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   34 CVVIALTAA---ANSLLIALICTQPALRNTS-NFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMC 109
Cdd:cd15935   5 VLVLACYAAillGNLLIVVTVHADPHLLQSPmYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFL 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 4504545  110 CSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWS 152
Cdd:cd15935  85 GGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWA 127
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
39-151 8.37e-04

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 41.24  E-value: 8.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLC 118
Cdd:cd15409  13 ITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECFLLA 92
                        90       100       110
                ....*....|....*....|....*....|...
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAW 151
Cdd:cd15409  93 AMAYDRYVAICNPLLYPVVMSNRLCVQLITASY 125
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
44-331 8.84e-04

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 40.97  E-value: 8.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLClLWTAF-DVMCCSASILNLCLISL 122
Cdd:cd15078  18 NLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGC-VWDGFsNSLFGIVSIMTLTVLAY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  123 DRYLLILSPlRYKLRMTPLRALALVlgaWsLAALASFLPLLLGW-------HELGHArppVPGQCRLLASLPFVLVASGL 195
Cdd:cd15078  97 ERYIRVVHA-KVVNFSWSWRAITYI---W-LYSLAWTGAPLLGWnrytlevHGLGCS---FDWKSKDPNDTSFVLLFFLG 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  196 TFFLPSGAICFTYCRILLAARKqavqvasLTTGMASQASETLQVprtprpgvesadsrrlaTKHSRKALKASLtlgILLG 275
Cdd:cd15078 169 CLVVPLGIMAYCYGHILYEIRM-------LRSVEDLQTFQVIKI-----------------LKYEKKVAKMCL---LMIS 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4504545  276 MFFVTWLPFFVANIVQAV--CDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15078 222 TFLICWMPYAVVSLLVTSgySKLVTPTIAIIPSLFAKSSTAYNPVIYIFMIRKFRQCL 279
7tmA_GPR153 cd15907
orphan G protein-coupled receptor 153, member of the class A family of seven-transmembrane G ...
97-324 9.09e-04

orphan G protein-coupled receptor 153, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 153 (GPR153) with unknown endogenous ligand and function. GPR153 shares a common evolutionary origin with GPR162 and is highly expressed in central nervous system (CNS) including the thalamus, cerebellum, and the arcuate nucleus. Although categorized as a member of the rhodopsin-like class A GPCRs, GPR153 contains HRM-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of class A receptors and important for efficient G protein-coupled signal transduction. Moreover, the LPxFL motif, a variant of NPxxY motif that plays a crucial role during receptor activation, is found at the end of TM7 in GPR153. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320573  Cd Length: 301  Bit Score: 41.09  E-value: 9.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   97 GLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPlLLGWH---ELGHAR 173
Cdd:cd15907  74 GLCKVFVSTFYTLTLVTCFSVTSLSYHRMWMVRWPVNYRLSNTKKQAVHTVMGIWMVSFILSTLP-AVGWHdttERFYTR 152
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  174 ppvpgQCRllaslpFVLVASGLTFflpsgAICFtycrILLAARKQAVQVasLTTGMASQASETLQVPRT--------PRP 245
Cdd:cd15907 153 -----DCR------FIVTEIGLGF-----GVCF----LLLISGSVAMGV--VCIGIALFQTFSIQTGHNidknkfnvPTI 210
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  246 GVESADSRRLATKHSRKALKASLTL-----GILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWlgyCnSTMNPIIY 320
Cdd:cd15907 211 VVEDAQGKRRSSIDGSEPIKTSLQItylisGIVFIYDFLMGFPILVVSFASLKADKSYNWMVLCVLW---C-SVAQSLLL 286

                ....
gi 4504545  321 PLFM 324
Cdd:cd15907 287 PMFL 290
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
31-330 9.23e-04

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 40.96  E-value: 9.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNAL------YGRWVLARGLCLLwta 104
Cdd:cd15345   5 IFFLVICSFIVLENLMVLIAIWKNNRFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKktfslsPTQWFLREGSMFV--- 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  105 fdvmCCSASILNLCLISLDRYLLILsplryklRMTPL------RALALVLGAWSLAALASFLPLLlGWHELGHarppVPG 178
Cdd:cd15345  82 ----ALGASTFSLLAIAIERHLTMI-------KMRPYdankryRVFLLIGTCWLISVLLGALPIL-GWNCLDN----LPD 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  179 QCRLLASLPFVLVASGLTFFLPS-GAICFTYCRILLAarkqavqvaslttgmasqasetlqvprtprpgVESADSRRLAT 257
Cdd:cd15345 146 CSTILPLYSKKYVAFCISIFIAIlVAIVILYARIYIL--------------------------------VKSSSRRVTNH 193
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  258 KHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTW---LGYCNSTMNPIIYPLFMRDFKRA 330
Cdd:cd15345 194 RNSERSMALLRTVVIVVGVFIACWSPLFILLLIDVACEVKQCPILYKADWfiaLAVLNSAMNPIIYTLASKEMRRA 269
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
30-153 9.97e-04

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 40.68  E-value: 9.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   30 AAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYGRWVLARGLCLL-WTAFdVM 108
Cdd:cd15155   4 GAVYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLF-VFTLPFKIFYNFNRHWPFGDSLCKIsGTAF-LT 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSL 153
Cdd:cd15155  82 NIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWIL 126
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
28-180 1.15e-03

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 40.66  E-value: 1.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMpPAMLNALygrWVLARGL----CLLWT 103
Cdd:cd15948   3 WISIPFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTV-PKILSIF---WFNSREInfnaCLVQM 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  104 AFdvmCCSASILN---LCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAA-LASFLPLLLgwHELGHARPPVPGQ 179
Cdd:cd15948  79 FF---LHSFSIMEsavLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVtLMTPLPFLL--RRLPYCRSHVIAH 153

                .
gi 4504545  180 C 180
Cdd:cd15948 154 C 154
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
47-160 1.24e-03

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 40.54  E-value: 1.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   47 LIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYL 126
Cdd:cd15944  34 MIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKVISFSGCATQFAFFVGFVDAECYVLAAMAYDRYV 113
                        90       100       110
                ....*....|....*....|....*....|....
gi 4504545  127 LILSPLRYKLRMTPLRALALVLGAWsLAALASFL 160
Cdd:cd15944 114 AICNPLLYSTLMSKRVCLQLMAGSY-LAGLVNLV 146
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
28-164 1.38e-03

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 40.52  E-value: 1.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCL--LWTAF 105
Cdd:cd15955   2 WIGIPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLaqMFFIH 81
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  106 DVMCCSASILnlCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAA-LASFLPLLL 164
Cdd:cd15955  82 TLQAFESGIL--LAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVvLIIPCPLLI 139
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
99-164 1.41e-03

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 40.38  E-value: 1.41e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545   99 CLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLL 164
Cdd:cd15913  73 CFLQFYFFFSLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVL 138
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
34-128 1.44e-03

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 40.51  E-value: 1.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   34 CVVIaLTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYGrWVLARGLCLLWTAFDVMCCSAS 113
Cdd:cd15174   9 LIFL-VGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLF-LCTLPFWATAASSG-WVFGTFLCKVVNSMYKINFYSC 85
                        90
                ....*....|....*
gi 4504545  114 ILNLCLISLDRYLLI 128
Cdd:cd15174  86 MLLLTCISVDRYIAI 100
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
39-164 1.51e-03

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 40.27  E-value: 1.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLC 118
Cdd:cd15939  13 ATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIFLLT 92
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLL 164
Cdd:cd15939  93 VMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILL 138
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
44-167 1.72e-03

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 39.86  E-value: 1.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLD 123
Cdd:cd15938  18 NLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFLLTVMAYD 97
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 4504545  124 RYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWH 167
Cdd:cd15938  98 RYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQ 141
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
35-217 1.90e-03

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 40.08  E-value: 1.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYG-RWVLARGLCLLWTAFDVMCCSAS 113
Cdd:cd15161   9 LVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSY-VLILPMRLVYHLSGnHWPFGEVPCRLAGFLFYLNMYAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  114 ILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALaSFLPLLLGwheLGHARPPVPGQCRLL----ASlPFV 189
Cdd:cd15161  88 LYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTV-AMAPLLVS---PQTVEVNNTTVCLQLyrekAS-RGA 162
                       170       180
                ....*....|....*....|....*...
gi 4504545  190 LVASGLTFFLPSGAICFTYCRILLAARK 217
Cdd:cd15161 163 LVSLAVAFTIPFVTTVTCYLLIIRSLRT 190
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
35-211 1.98e-03

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 39.77  E-value: 1.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIA-LICTQPALRNTSNFFLVSLFTSDLMvgLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSAS 113
Cdd:cd15188   9 LVFLLGLAGNLLLFVvLLLYVPKKKKMTEVYLLNLAVSDLL--FLVTLPFWAMYVAWHWVFGSFLCKFVSTLYTINFYSG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  114 ILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLP--LLLGWHELGHARPPVP---GQCRLLASLPF 188
Cdd:cd15188  87 IFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALS-VPdmVFVQTHHTNNGVWVCHadyGGHHTIWKLVF 165
                       170       180
                ....*....|....*....|...
gi 4504545  189 VLVASGLTFFLPSGAICFTYCRI 211
Cdd:cd15188 166 QFQQNLLGFLFPLLAMVFFYSRI 188
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
35-214 2.08e-03

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 39.69  E-value: 2.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15412   9 VIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEY 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWH-------ELGH---ARPPVpgqCRLLA 184
Cdd:cd15412  89 YMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRlsfcgsnVINHfycADPPL---IKLSC 165
                       170       180       190
                ....*....|....*....|....*....|....*
gi 4504545  185 SLPFV-----LVASGLTFFLPSGAICFTYCRILLA 214
Cdd:cd15412 166 SDTYVketamFIVAGFNLSSSLLIILISYLFILIA 200
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
44-331 2.19e-03

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 39.86  E-value: 2.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPpamlnalYGRWVLARGLCLLWTAFDVMC----------CSAS 113
Cdd:cd15006  17 NFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVP-------FDIVLSASPHCCWWIYTLLFCkvikflhkvfCSVT 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  114 ILNLCLISLDRYLLILSPLRYKLrmTPLRALALVLGAWSLAALASfLPL--LLGWHELGHARPPVPGQCRLLASLPFVLV 191
Cdd:cd15006  90 VLSFAAIALDRYYSVLYPLERKI--SDAKSRDLVIYIWAHAVVAS-VPVfaVTNVTDIYAMSTCTESWGYSLGHLVYVII 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  192 ASGLTFFLPSgAICFTYC----RILLAARKQAVQVASLTTgmasqASETLQVPRTprpgvesadSRRLATKHSrkalkas 267
Cdd:cd15006 167 YNITTVILPV-AVVFLFMilirRALSASQKKKVIIAALRT-----PQNTISIPYV---------SQREAELHA------- 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  268 lTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLT--WLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15006 225 -MLLSMVLVFILCSVPYATLVIYRTILNISDISVFLLLTaiWLPKVSLLANPLLFLTVNKSVRKCL 289
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
35-160 2.27e-03

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 39.74  E-value: 2.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNAL-YGRWVLARGLCLLWTAFDVMCCSAS 113
Cdd:cd15916   9 IIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLePGGKVISFGGCVAQLYFFHFLGSTE 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 4504545  114 ILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFL 160
Cdd:cd15916  89 CFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAI 135
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
44-331 2.28e-03

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 39.67  E-value: 2.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYGrWVLARGLCLLWTAFDVMCCSASILNLCLISLD 123
Cdd:cd15180  18 NGLVLAVLLQKRRNLSVTDTFILHLALADILL-LVTLPFWAVQAVHG-WIFGTGLCKLAGAVFKINFYCGIFLLACISFD 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  124 RYLLILSPLRYKLRMTPLRALALVLGAWSLAALASfLP--LLLGWH--------ELGHARPPVPGQCRLLASLPFVLVAs 193
Cdd:cd15180  96 RYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLS-IPdfIFLEATkdprqnktECVHNFPQSDTYWWLALRLLYHIVG- 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  194 gltFFLPSGAICFTYCRILLaarkqavqvaslttgmasqasetlqvprtprpgvesadsRRLATKHSRKALKASLTLGIL 273
Cdd:cd15180 174 ---FLLPLAVMVYCYTSILL---------------------------------------RLLRSSQGFQKQRAIRVIVAV 211
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4504545  274 LGMFFVTWLPFfvaNIVQAVCDCISPGLFD--------------VLTWLGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15180 212 VVVFFLCWTPY---NIALLVDTLIDLSVLDrncgtesrldialsVTSSLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
31-216 2.29e-03

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 39.76  E-value: 2.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYGrWVLARGLCLLWTAFDVMCC 110
Cdd:cd15177   5 CVYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLL-LLTLPFAAAETLQG-WIFGNAMCKLIQGLYAINF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  111 SASILNLCLISLDRYLLIL-SPLRYKLR-MTPLRALALVLGAWSLAALASfLPLLLGWH-----ELGHARPPVPGQCRLL 183
Cdd:cd15177  83 YSGFLFLTCISVDRYVVIVrATSAHRLRpKTLFYSVLTSLIVWLLSILFA-LPQLIYSRvenrsELSSCRMIFPEVVSRT 161
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 4504545  184 ASLPFVLVASGLTFFLPSGAICFTYC---RILLAAR 216
Cdd:cd15177 162 VKGATALTQVVLGFAIPLIVMAVCYAaigRTLLAAR 197
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
44-151 2.67e-03

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 39.38  E-value: 2.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWT-AFDVMCCSASILnLCLISL 122
Cdd:cd15946  18 NGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMyIFLALGITECTL-FSVMAY 96
                        90       100
                ....*....|....*....|....*....
gi 4504545  123 DRYLLILSPLRYKLRMTPLRALALVLGAW 151
Cdd:cd15946  97 DRYVAICHPLRYKVIMSWGLCILMVAGSW 125
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
44-159 2.76e-03

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 39.43  E-value: 2.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLD 123
Cdd:cd15185  18 NVVVVVILIKYRRLRIMTNIYLLNLAISDLLF-LFTLPFWIHYVRWNNWVFGHGMCKLLSGFYYLGLYSEIFFIILLTID 96
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 4504545  124 RYLLILSPLryklrmTPLRALALVLG------AWSLAALASF 159
Cdd:cd15185  97 RYLAIVHAV------FALRARTVTFGiitsiiTWGLAVLAAL 132
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
34-224 2.78e-03

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 39.36  E-value: 2.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   34 CVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLN-ALYGRWVLARGLCLLWTAFDVMCCSA 112
Cdd:cd16001   8 SVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLY-VCSLPLLIVNyAMRDRWPFGDFLCKLVRFLFYTNLYG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  113 SILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALaSFLPLLLGWHELGHARPPVpgqCRLLAS------- 185
Cdd:cd16001  87 SILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVL-QLLPTLVYARTGSINNRTV---CYDLTSpdnfgny 162
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 4504545  186 LPFVLVASGLTFFLPSGAICFTYCRIL--LAARKQAVQVAS 224
Cdd:cd16001 163 FPYGMVLTVTGFLIPFLIILLCYCLMIksLIRSEEAAGVGK 203
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
28-320 3.14e-03

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 39.35  E-value: 3.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYGrWVLARGLCLLWTAFDV 107
Cdd:cd15181   2 FIPLAYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLL-LLTFPFSVVESIAG-WVFGTFLCKLVGAIHK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLrYKLRMTPLRALALVLGAWSLAALASFLP---LLLGWHELGHARPPVPGQCRLLA 184
Cdd:cd15181  80 LNFYCSSLLLACISVDRYLAIVHAI-HSYRHRRLRSVHLTCGSIWLVCFLLSLPnlvFLEVETSTNANRTSCSFHQYGIH 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  185 SLPFVLVASGLT----FFLPSGAICFTYCRILLAARKQavqvaslttgmasqasetlqvprtprpgvesadSRRLATKhs 260
Cdd:cd15181 159 ESNWWLTSRFLYhvvgFFLPLLIMGYCYATIVVTLCQS---------------------------------SRRLQKQ-- 203
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  261 rKALKASLTlgiLLGMFFVTWLPFFVANIVQAVC-------DCISPGLFD----VLTWLGYCNSTMNPIIY 320
Cdd:cd15181 204 -KAIRVAIL---VTLVFCLCWLPYNIVIFLDTLDdlkavvkNCKLNDLLDaaitVTESLGFSHCCLNPILY 270
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
39-173 3.15e-03

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 39.29  E-value: 3.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDL--MVGLVvmpPAMLNALYG--RWVLARGlCLLWTAFDVMCCSASI 114
Cdd:cd15434  13 LTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLcfTTSII---PQMLVNLWGpdKTISYVG-CAIQLFIALGLGGTEC 88
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFL--PLLLGWHELGHAR 173
Cdd:cd15434  89 VLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVlsPLTLSLPRCGHHR 149
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
40-154 3.32e-03

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 39.32  E-value: 3.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   40 TAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCL 119
Cdd:cd15405  14 TVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISECYVLTA 93
                        90       100       110
                ....*....|....*....|....*....|....*
gi 4504545  120 ISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLA 154
Cdd:cd15405  94 MAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMG 128
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
28-164 3.48e-03

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 39.19  E-value: 3.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMpPAMLNALygrWVLARGL----CLLWT 103
Cdd:cd15917   2 WLSIPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTV-PKMLGIF---WFNAREIsfdaCLAQM 77
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504545  104 AFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTP--LRALALVLGAWSLAALASFlPLLL 164
Cdd:cd15917  78 FFIHSFTAMESGVLLAMAFDRYVAICYPLRYTTILTNtvVGKIGLAILLRAVALIIPL-PLLV 139
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
59-320 3.70e-03

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 39.00  E-value: 3.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   59 NTSNFFLVSLFTSDLMVgLVVMPPAMLNALYG-RWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPlRYKLR 137
Cdd:cd15199  33 KPYAVYLLNLVLADVLL-LICLPFKAYFYLNGnRWSLGGGTCKALLFMLSLSRGVSIAFLTAVALDRYFRVVHP-RGKKN 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  138 MTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPG-QCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAAR 216
Cdd:cd15199 111 SLSLQAAPYISFLVWLLLVGLTIPTLLASQPKNFTECNSFSpKDDEDFSDTWQEAVFFLQFLLPFGLIVFCTVRIIRRLK 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  217 KQAVQVASlttgmasqasetlqvprtprpgvesadsrrlatkhSRKALKASLTLGILLGMFFVTWLPFFVANIVQAV--- 293
Cdd:cd15199 191 KRLRDVGK-----------------------------------QPKLQRAMALVTSVVVVFGFCFLPCFLARVLMLIfqn 235
                       250       260       270
                ....*....|....*....|....*....|..
gi 4504545  294 -----CDCISPGLFDVLTWLGYCNSTMNPIIY 320
Cdd:cd15199 236 kescnALNIAVHTYDVTMCLTYLNSVLDPIVY 267
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
39-151 4.15e-03

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 39.00  E-value: 4.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLC 118
Cdd:cd15433  13 LTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAECVLLA 92
                        90       100       110
                ....*....|....*....|....*....|...
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAW 151
Cdd:cd15433  93 VMAFDRYAAVCRPLHYAALMSPRLCQTLASISW 125
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
35-159 4.16e-03

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 38.78  E-value: 4.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRwvlaRGLCLLWTA-----FDVMC 109
Cdd:cd15417   9 GIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQ----KTISFVGCAtqyfvFSGMG 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 4504545  110 CSASILnLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASF 159
Cdd:cd15417  85 LTECFL-LAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSL 133
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
35-156 4.23e-03

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 39.23  E-value: 4.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545    35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMvgLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:PHA02638 106 IIIFILGLFGNAAIIMILFCKKIKTITDIYIFNLAISDLI--FVIDFPFIIYNEFDQWIFGDFMCKVISASYYIGFFSNM 183
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 4504545   115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAAL 156
Cdd:PHA02638 184 FLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLI 225
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
42-160 4.25e-03

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 38.99  E-value: 4.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   42 AANSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYGR-WVLARGLCLLWTAFDVMCCSASILNLCLI 120
Cdd:cd14988  16 VENVLVIWVNWHRWGSKNLVNLYILNMAIADLGV-VLTLPVWMLEVMLDYtWLWGSFLCKFTHYFYFANMYSSIFFLTCL 94
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 4504545  121 SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFL 160
Cdd:cd14988  95 SVDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLSAIIPLP 134
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
44-328 4.29e-03

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 38.62  E-value: 4.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   44 NSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLvVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCsaSILNLCLISLD 123
Cdd:cd15163  18 NSLALYVFCFRTKTKTTSVIYTINLVVTDLLVGL-SLPTRIVMYYSAGNCLTCSFVHIFSYFVNMYC--SILFLTCICVD 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  124 RYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLllgwhelghARPPVPGQCrllaSLPFVLVASGLTFFLPSGA 203
Cdd:cd15163  95 RYLAIVQVEASRRWRNPNYAKGICVFIWLFAIVVTFSIL---------TTAIKFASC----CLSKLFALTVFEFFLPLLI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  204 ICFTYCRILLAARKqavqvasltTGMASQASEtlqvprtprpgvesadsRRlatkhsrkaLKASLTLGILLGMFFVTWLP 283
Cdd:cd15163 162 ITFFTIRIMCALSR---------PGLMHQSRE-----------------RR---------MRAVQLLITVLIIFMICFTP 206
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 4504545  284 FFVANIVQAVCDCI----SPGLFDVLTWLGYCNSTMNPIIYPLFMRDFK 328
Cdd:cd15163 207 FHVRQVAVAFNPDIphhtSLIVYHVTVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
39-160 4.43e-03

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 38.92  E-value: 4.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLC 118
Cdd:cd15429  13 LTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEFILLA 92
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFL 160
Cdd:cd15429  93 VMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLV 134
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
258-329 4.63e-03

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 38.59  E-value: 4.63e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  258 KHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVC------DCISPGLFDVL----TWLGYCNSTMNPIIYPLFMRDF 327
Cdd:cd15381 201 KEIQTERKATVLVLAVLLMFFICWLPFHIFTFLDTLHklglisGCRWEDILDIGtqiaTFLAYSNSCLNPLLYVIVGKHF 280

                ..
gi 4504545  328 KR 329
Cdd:cd15381 281 RK 282
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
35-214 6.35e-03

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 38.50  E-value: 6.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15416   9 VIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVEC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAW------SLAALASFLPLLL-GWHELGHARPPVPGQCRLLASLP 187
Cdd:cd15416  89 FLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYlggclnALVFTTCVFSLSFcGPNEINHFFCDFPPLLKLSCSDI 168
                       170       180       190
                ....*....|....*....|....*....|..
gi 4504545  188 FVL-----VASGLTFFLPSGAICFTYCRILLA 214
Cdd:cd15416 169 RLAkilpsISSGIIILVTVLTIIISYLYILIA 200
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
35-331 7.28e-03

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 38.21  E-value: 7.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   35 VVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVgLVVMPPAMLNALYGrWVLARGLCLLWTAFDVMCCSASI 114
Cdd:cd15179   9 IIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLF-VLTLPFWAVDAAAN-WYFGNFLCKAVHVIYTVNLYSSV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  115 LNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLL------LGWHELGHARPPVPGQCRLLASLPF 188
Cdd:cd15179  87 LILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVfakvseLDDRYICDRIYPEDTFELWVVAFRF 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545  189 VLVASGltFFLPSGAICFTYCRIllaarkqavqVASLTTGMASQasetlqvprtprpgvesadsrrlatkhSRKALKASL 268
Cdd:cd15179 167 QHILVG--LVLPGLVILTCYCII----------ISKLSHSKGHQ---------------------------KRKALKTTV 207
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504545  269 tlgILLGMFFVTWLPFFVA---------NIVQAVCDCISpglfDVLTW------LGYCNSTMNPIIYPLFMRDFKRAL 331
Cdd:cd15179 208 ---ILILAFFACWLPYYIGisidtfmllEIIKQSCEMEQ----TVHKWisiteaLAFFHCCLNPILYAFLGAKFKTSA 278
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
29-164 7.54e-03

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 38.02  E-value: 7.54e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   29 VAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVmpPAMLNALYGRWVLARGLCLLWTAFDVM 108
Cdd:cd15178   3 LCVIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTL--PFWAVSVVKGWIFGTFMCKLVSLLQEA 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4504545  109 CCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALAlVLGAWSLAALASfLPLLL 164
Cdd:cd15178  81 NFYSGILLLACISVDRYLAIVHATRALTQKRHLVKFV-CAGVWLLSLLLS-LPALL 134
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
28-166 8.45e-03

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 38.10  E-value: 8.45e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDV 107
Cdd:cd15951   2 WISIPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIH 81
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLRYKLRMTPLR----ALALVLGAwslAALASFLPLLLGW 166
Cdd:cd15951  82 SFSTMESGIFVAMALDRYVAICNPLRHSTILTNSVvakiGLAVVLRG---GILVSPHPFLLRR 141
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
39-154 8.52e-03

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 37.85  E-value: 8.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   39 LTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLC 118
Cdd:cd15233  13 VTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADCFLLT 92
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 4504545  119 LISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLA 154
Cdd:cd15233  93 AMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACA 128
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
31-158 8.65e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 37.88  E-value: 8.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   31 AALCVVIALTAAAN-SLLIALICTQpalRNTS--NFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDV 107
Cdd:cd15385   5 AVLAVIFAVAVIGNsSVLLALYKTK---KKASrmHLFIKHLSLADLVVAFFQVLPQLCWDITYRFYGPDFLCRIVKHLQV 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLRyKLRMTPLRALALVLGAWSLAALAS 158
Cdd:cd15385  82 LGMFASTYMLVMMTADRYIAICHPLK-TLQQPTKRSYLMIGSAWALSFILS 131
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
28-139 8.70e-03

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 37.88  E-value: 8.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504545   28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDV 107
Cdd:cd15954   2 WISIPFCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVH 81
                        90       100       110
                ....*....|....*....|....*....|..
gi 4504545  108 MCCSASILNLCLISLDRYLLILSPLRYKLRMT 139
Cdd:cd15954  82 TFTGMESGVLMLMALDRYVAICYPLRYATILT 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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