|
Name |
Accession |
Description |
Interval |
E-value |
| AMP_deaminase |
pfam19326 |
AMP deaminase; |
137-768 |
0e+00 |
|
AMP deaminase;
Pssm-ID: 437158 [Multi-domain] Cd Length: 622 Bit Score: 1101.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 137 PEFQRVTISGDYCAGITLEDYEQAAKSLAKALMIREKYArlayhrFPRITSQYLGHPRADTAPP-EEGLPDFHPPPLPQE 215
Cdd:pfam19326 1 PEVQRVTISGDYKLGVPTEDLEEAYKSLAECLEIREKYM------FPETTAPYLKSVQGEDSTPkENDEPVFHPPPKKGE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 216 DPYCLDDAPPNLDYLVHMQGGILFVYDNKKMLEHqephSLPYPDLETYTVDMSHILALITDGPTKTYCHRRLNFLESKFS 295
Cdd:pfam19326 75 DPYELFNFPPDLGYHLRMQDGVVHVYANKDALED----SLPYPDLRDFYTDLEHLLALIADGPIKTFCHRRLQYLESKFN 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 296 LHEMLNEMSEFKELKSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQVFDGLHMDP 375
Cdd:pfam19326 151 LHLMLNEMKELKAQKSNPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKSKLRKEPDEVVIFRDGKYLTLREVFESLKLTG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 376 YDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARMVKEVARELEESKYQYSEPRLSIYGRS 455
Cdd:pfam19326 231 YDLSVDTLDVHADRDTFHRFDKFNLKYNPIGESRLREIFLKTDNYINGRYLAEITKEVFSDLEESKYQMAEYRISIYGRS 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 456 PEEWPNLAYWFIQHKVYSPNMRWIIQVPRIYDIFRSKKLLPNFGKMLENIFLPLFKATINPQDHRELHLFLKYVTGFDSV 535
Cdd:pfam19326 311 PDEWDKLASWIVDNKVYSPNVRWLIQVPRLYDIYKKKGIVPSFQKMLENIFLPLFEATVNPQSHPELHVFLKRVIGFDSV 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 536 DDESKHSDHMFSdKSPNPDVWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNI 615
Cdd:pfam19326 391 DDESKPERRMFR-KSPKPALWTNEQNPPYSYYLYYMYANIAVLNSLRKERGFNTFVLRPHCGEAGDIDHLVSAFLLAHGI 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 616 SHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVW 695
Cdd:pfam19326 470 SHGILLRKSPVLQYLYYLAQIGIAMSPLSNNSLFLEYHKNPFPEFFKRGLNVSLSTDDPLQFHFTKEPLMEEYSIAAQVW 549
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4502079 696 KLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYYKEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKS 768
Cdd:pfam19326 550 KLSACDMCELARNSVLQSGFSHQLKSHWLGKDYYKEGPEGNDIRRTNVPDIRVAYRYETLCQELALISDAVKS 622
|
|
| AMP_deaminase |
TIGR01429 |
AMP deaminase; This model describes AMP deaminase, a large, well-conserved eukaryotic protein ... |
155-762 |
0e+00 |
|
AMP deaminase; This model describes AMP deaminase, a large, well-conserved eukaryotic protein involved in energy metabolism. Most members of the family have an additional, poorly alignable region of 150 amino acids or more N-terminal to the region included in the model.
Pssm-ID: 273618 [Multi-domain] Cd Length: 611 Bit Score: 1054.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 155 EDYEQAAKSLAKALMIREKYARLAYHRFPRITSQYL-GHPRADTAPPEEGLPDFHPPPLPQEDPYCLDDAPP--NLDYLV 231
Cdd:TIGR01429 1 EDLAEAAKSLAKALMLREKYARLAYHRFPDTTAQYLsHQGYPESVPLEEGLPDFHPPPDPQEDPYCLDDDAPpiELGYLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 232 HMQGGILFVYDNKKMLEHQEPHSLPYPDLETYTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKELKS 311
Cdd:TIGR01429 81 RMHGGVLFVYDNDTMLERQEPHFLVPPTLETYYVDMEHLLALISDGPTKSFCFRRLQYLESKFNLHELLNEMSELKEQKS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 312 NPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQVFDGLHMDPYDLTVDSLDVHAGRQT 391
Cdd:TIGR01429 161 VPHRDFYNVRKVDTHIHAAASMNQKHLLRFIKHKLKTEPDETVIERDGKKLTLREVFDSLHLDPYDLSVDTLDVHADRNT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 392 FHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARMVKEVARELEESKYQYSEPRLSIYGRSPEEWPNLAYWFIQHKV 471
Cdd:TIGR01429 241 FHRFDKFNLKYNPVGESRLREIFLKTDNYIGGKYFAELVKEVFTDLEDSKYQYAEPRLSIYGRSPKEWDSLARWIIDHDV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 472 YSPNMRWIIQVPRIYDIFRSKKLLPNFGKMLENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDKSP 551
Cdd:TIGR01429 321 FSPNVRWLIQVPRLYDVYRSKKLVPNFGDMLENVFLPLFEVTKDPSSHPELHLFLQQVTGFDSVDDESKHEDHMFSRKFP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 552 NPDVWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYLY 631
Cdd:TIGR01429 401 SPDEWTSEQNPPYSYYLYYMYANIMVLNNFRRERGLNTFLLRPHCGEAGSVDHLVSAFLTSHGINHGILLRKVPVLQYLY 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 632 YLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVL 711
Cdd:TIGR01429 481 YLTQIPIAMSPLSNNSLFLEYSKNPLPEYLHKGLNVSLSTDDPLQFHYTKEALMEEYAIAAQVWKLSTCDMCELARNSVL 560
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|.
gi 4502079 712 QSGLSHQEKQKFLGQNYYKEGPEGNDIRKTNVAQIRMAFRYETLCNELSFL 762
Cdd:TIGR01429 561 QSGFEHQVKQHWLGPNYYKEGPEGNDIRRTNVPDIRVAFRYETLCNELSLL 611
|
|
| AMPD |
cd01319 |
AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at ... |
263-759 |
0e+00 |
|
AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
Pssm-ID: 238644 Cd Length: 496 Bit Score: 892.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 263 YTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKELKSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFI 342
Cdd:cd01319 1 FYLDLEFLLALISDGPAKSFCYRRLQYLESKFQLHVLLNEDRELKEQKTVPHRDFYNVRKVDTHVHHSACMNQKHLLRFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 343 KHTYQTEPDRTVAEKRGRKITLRQVFDGLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLG 422
Cdd:cd01319 81 KKKLRTEPDEVVIFRDGKKLTLKEVFDSLKLTAYDLSVDTLDVHADRNTFHRFDKFNLKYNPIGESRLREIFLKTDNYIN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 423 GEYFARMVKEVARELEESKYQYSEPRLSIYGRSPEEWPNLAYWFIQHKVYSPNMRWIIQVPRIYDIFRSKKLLPNFGKML 502
Cdd:cd01319 161 GRYLAEITKEVFSDLEESKYQHAEYRLSIYGRSKDEWDKLASWVVDNDLFSPNVRWLIQIPRLYDVYKKSGIVNSFQEML 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 503 ENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESKhSDHMFSDKSPNPDVWTSEQNPPYSYYLYYMYANIMVLNNLR 582
Cdd:cd01319 241 ENIFEPLFEATKDPSSHPELHVFLQQVIGFDSVDDESK-SERRFTRKFPKPEEWTSEENPPYSYYLYYMYANITTLNSFR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 583 RERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLH 662
Cdd:cd01319 320 KARGFNTFVLRPHCGEAGDIDHLASAFLLAHGISHGINLRKVPVLQYLYYLTQIGIAMSPLSNNSLFLSYEKNPFPEFFK 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 663 KGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYYKEGPEGNDIRKTN 742
Cdd:cd01319 400 RGLNVSLSTDDPLQFHFTKEPLMEEYSIAAQVWKLSTCDMCELARNSVLQSGFEHSIKRHWLGPNYLKRGVAGNDIRRTN 479
|
490
....*....|....*..
gi 4502079 743 VAQIRMAFRYETLCNEL 759
Cdd:cd01319 480 VPQIRMAYRYETLCEEL 496
|
|
| PLN02768 |
PLN02768 |
AMP deaminase |
109-771 |
0e+00 |
|
AMP deaminase
Pssm-ID: 215411 Cd Length: 835 Bit Score: 683.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 109 PAASPAMSPTTpVVTGATSLPTPAPYAM------PE---FQRVTISGdycAGITLEDYEQAAKSLAKALMIREKYARlay 179
Cdd:PLN02768 187 PIPASSMIRSH-SVSGDLHGVQPDPIAAdilrkePEqetFVRLNITP---LEVPSPDEVEAYKVLQECLELRKRYVF--- 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 180 hrfpritsqylghpRADTAPPEEGLPDFHPPPLPQEDPYCLDDAPPNlDYLVHMQGGILFVYDNKkmleHQEPHSLPYPD 259
Cdd:PLN02768 260 --------------REEVAPWEKEIISDPSTPKPNPNPFSYTPEGKS-DHYFEMQDGVVHVYANK----DSKEELFPVAD 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 260 LETYTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKELKSNPHRDFYNVRKVDTHIHAAACMNQKHLL 339
Cdd:PLN02768 321 ATTFFTDLHHILRVIAAGNIRTLCHHRLNLLEQKFNLHLMLNADREFLAQKSAPHRDFYNVRKVDTHVHHSACMNQKHLL 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 340 RFIKHTYQTEPDRTVAEKRGRKITLRQVFDGLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTEN 419
Cdd:PLN02768 401 RFIKSKLRKEPDEVVIFRDGTYLTLKEVFESLDLTGYDLNVDLLDVHADKSTFHRFDKFNLKYNPCGQSRLREIFLKQDN 480
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 420 YLGGEYFARMVKEVARELEESKYQYSEPRLSIYGRSPEEWPNLAYWFIQHKVYSPNMRWIIQVPRIYDIFRSKKLLPNFG 499
Cdd:PLN02768 481 LIQGRFLAELTKQVFSDLEASKYQMAEYRISIYGRKQSEWDQLASWIVNNELYSENVVWLIQLPRLYNVYKEMGIVTSFQ 560
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 500 KMLENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESK----HSDHMfsdksPNPDVWTSEQNPPYSYYLYYMYANI 575
Cdd:PLN02768 561 NILDNIFIPLFEVTVDPDSHPQLHVFLKQVVGLDLVDDESKperrPTKHM-----PTPAQWTNVFNPAFSYYVYYCYANL 635
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 576 MVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKN 655
Cdd:PLN02768 636 YTLNKLRESKGMTTIKFRPHSGEAGDIDHLAATFLTCHNIAHGINLRKSPVLQYLYYLAQIGLAMSPLSNNSLFLDYHRN 715
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 656 PLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYYKEGPEG 735
Cdd:PLN02768 716 PFPMFFLRGLNVSLSTDDPLQIHLTKEPLVEEYSIAASVWKLSSCDLCEIARNSVYQSGFSHALKSHWIGKEYYKRGPDG 795
|
650 660 670
....*....|....*....|....*....|....*...
gi 4502079 736 NDIRKTNVAQIRMAFRYETLCNELS--FLSDAMKSEEI 771
Cdd:PLN02768 796 NDIHKTNVPHIRVEFRDTIWKEEMQqvYLGKAKIPEEV 833
|
|
| Add |
COG1816 |
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the ... |
583-726 |
2.22e-18 |
|
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 441421 Cd Length: 326 Bit Score: 87.06 E-value: 2.22e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 583 RERGLstfLFRPHCGEAGSITHLVSA--FLTADNISHGLLLKKSPVLqyLYYLA--QIPIAMSPLSNNSL--FLEYSKNP 656
Cdd:COG1816 178 REAGL---HLTAHAGEAGGPESIWEAldLLGAERIGHGVRAIEDPAL--VARLAdrGIPLEVCPTSNVQLgvVPSLAEHP 252
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 657 LREFLHKGLHVSLSTDDPMQFHYTkeaLMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQ 726
Cdd:COG1816 253 LRRLLDAGVRVTLNTDDPLYFGTT---LTDEYELAAEAFGLSDADLAQLARNAIEASFLPEEEKAALLAE 319
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| AMP_deaminase |
pfam19326 |
AMP deaminase; |
137-768 |
0e+00 |
|
AMP deaminase;
Pssm-ID: 437158 [Multi-domain] Cd Length: 622 Bit Score: 1101.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 137 PEFQRVTISGDYCAGITLEDYEQAAKSLAKALMIREKYArlayhrFPRITSQYLGHPRADTAPP-EEGLPDFHPPPLPQE 215
Cdd:pfam19326 1 PEVQRVTISGDYKLGVPTEDLEEAYKSLAECLEIREKYM------FPETTAPYLKSVQGEDSTPkENDEPVFHPPPKKGE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 216 DPYCLDDAPPNLDYLVHMQGGILFVYDNKKMLEHqephSLPYPDLETYTVDMSHILALITDGPTKTYCHRRLNFLESKFS 295
Cdd:pfam19326 75 DPYELFNFPPDLGYHLRMQDGVVHVYANKDALED----SLPYPDLRDFYTDLEHLLALIADGPIKTFCHRRLQYLESKFN 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 296 LHEMLNEMSEFKELKSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQVFDGLHMDP 375
Cdd:pfam19326 151 LHLMLNEMKELKAQKSNPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKSKLRKEPDEVVIFRDGKYLTLREVFESLKLTG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 376 YDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARMVKEVARELEESKYQYSEPRLSIYGRS 455
Cdd:pfam19326 231 YDLSVDTLDVHADRDTFHRFDKFNLKYNPIGESRLREIFLKTDNYINGRYLAEITKEVFSDLEESKYQMAEYRISIYGRS 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 456 PEEWPNLAYWFIQHKVYSPNMRWIIQVPRIYDIFRSKKLLPNFGKMLENIFLPLFKATINPQDHRELHLFLKYVTGFDSV 535
Cdd:pfam19326 311 PDEWDKLASWIVDNKVYSPNVRWLIQVPRLYDIYKKKGIVPSFQKMLENIFLPLFEATVNPQSHPELHVFLKRVIGFDSV 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 536 DDESKHSDHMFSdKSPNPDVWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNI 615
Cdd:pfam19326 391 DDESKPERRMFR-KSPKPALWTNEQNPPYSYYLYYMYANIAVLNSLRKERGFNTFVLRPHCGEAGDIDHLVSAFLLAHGI 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 616 SHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVW 695
Cdd:pfam19326 470 SHGILLRKSPVLQYLYYLAQIGIAMSPLSNNSLFLEYHKNPFPEFFKRGLNVSLSTDDPLQFHFTKEPLMEEYSIAAQVW 549
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4502079 696 KLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYYKEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKS 768
Cdd:pfam19326 550 KLSACDMCELARNSVLQSGFSHQLKSHWLGKDYYKEGPEGNDIRRTNVPDIRVAYRYETLCQELALISDAVKS 622
|
|
| AMP_deaminase |
TIGR01429 |
AMP deaminase; This model describes AMP deaminase, a large, well-conserved eukaryotic protein ... |
155-762 |
0e+00 |
|
AMP deaminase; This model describes AMP deaminase, a large, well-conserved eukaryotic protein involved in energy metabolism. Most members of the family have an additional, poorly alignable region of 150 amino acids or more N-terminal to the region included in the model.
Pssm-ID: 273618 [Multi-domain] Cd Length: 611 Bit Score: 1054.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 155 EDYEQAAKSLAKALMIREKYARLAYHRFPRITSQYL-GHPRADTAPPEEGLPDFHPPPLPQEDPYCLDDAPP--NLDYLV 231
Cdd:TIGR01429 1 EDLAEAAKSLAKALMLREKYARLAYHRFPDTTAQYLsHQGYPESVPLEEGLPDFHPPPDPQEDPYCLDDDAPpiELGYLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 232 HMQGGILFVYDNKKMLEHQEPHSLPYPDLETYTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKELKS 311
Cdd:TIGR01429 81 RMHGGVLFVYDNDTMLERQEPHFLVPPTLETYYVDMEHLLALISDGPTKSFCFRRLQYLESKFNLHELLNEMSELKEQKS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 312 NPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQVFDGLHMDPYDLTVDSLDVHAGRQT 391
Cdd:TIGR01429 161 VPHRDFYNVRKVDTHIHAAASMNQKHLLRFIKHKLKTEPDETVIERDGKKLTLREVFDSLHLDPYDLSVDTLDVHADRNT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 392 FHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARMVKEVARELEESKYQYSEPRLSIYGRSPEEWPNLAYWFIQHKV 471
Cdd:TIGR01429 241 FHRFDKFNLKYNPVGESRLREIFLKTDNYIGGKYFAELVKEVFTDLEDSKYQYAEPRLSIYGRSPKEWDSLARWIIDHDV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 472 YSPNMRWIIQVPRIYDIFRSKKLLPNFGKMLENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDKSP 551
Cdd:TIGR01429 321 FSPNVRWLIQVPRLYDVYRSKKLVPNFGDMLENVFLPLFEVTKDPSSHPELHLFLQQVTGFDSVDDESKHEDHMFSRKFP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 552 NPDVWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYLY 631
Cdd:TIGR01429 401 SPDEWTSEQNPPYSYYLYYMYANIMVLNNFRRERGLNTFLLRPHCGEAGSVDHLVSAFLTSHGINHGILLRKVPVLQYLY 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 632 YLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVL 711
Cdd:TIGR01429 481 YLTQIPIAMSPLSNNSLFLEYSKNPLPEYLHKGLNVSLSTDDPLQFHYTKEALMEEYAIAAQVWKLSTCDMCELARNSVL 560
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|.
gi 4502079 712 QSGLSHQEKQKFLGQNYYKEGPEGNDIRKTNVAQIRMAFRYETLCNELSFL 762
Cdd:TIGR01429 561 QSGFEHQVKQHWLGPNYYKEGPEGNDIRRTNVPDIRVAFRYETLCNELSLL 611
|
|
| AMPD |
cd01319 |
AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at ... |
263-759 |
0e+00 |
|
AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
Pssm-ID: 238644 Cd Length: 496 Bit Score: 892.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 263 YTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKELKSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFI 342
Cdd:cd01319 1 FYLDLEFLLALISDGPAKSFCYRRLQYLESKFQLHVLLNEDRELKEQKTVPHRDFYNVRKVDTHVHHSACMNQKHLLRFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 343 KHTYQTEPDRTVAEKRGRKITLRQVFDGLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLG 422
Cdd:cd01319 81 KKKLRTEPDEVVIFRDGKKLTLKEVFDSLKLTAYDLSVDTLDVHADRNTFHRFDKFNLKYNPIGESRLREIFLKTDNYIN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 423 GEYFARMVKEVARELEESKYQYSEPRLSIYGRSPEEWPNLAYWFIQHKVYSPNMRWIIQVPRIYDIFRSKKLLPNFGKML 502
Cdd:cd01319 161 GRYLAEITKEVFSDLEESKYQHAEYRLSIYGRSKDEWDKLASWVVDNDLFSPNVRWLIQIPRLYDVYKKSGIVNSFQEML 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 503 ENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESKhSDHMFSDKSPNPDVWTSEQNPPYSYYLYYMYANIMVLNNLR 582
Cdd:cd01319 241 ENIFEPLFEATKDPSSHPELHVFLQQVIGFDSVDDESK-SERRFTRKFPKPEEWTSEENPPYSYYLYYMYANITTLNSFR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 583 RERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLH 662
Cdd:cd01319 320 KARGFNTFVLRPHCGEAGDIDHLASAFLLAHGISHGINLRKVPVLQYLYYLTQIGIAMSPLSNNSLFLSYEKNPFPEFFK 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 663 KGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYYKEGPEGNDIRKTN 742
Cdd:cd01319 400 RGLNVSLSTDDPLQFHFTKEPLMEEYSIAAQVWKLSTCDMCELARNSVLQSGFEHSIKRHWLGPNYLKRGVAGNDIRRTN 479
|
490
....*....|....*..
gi 4502079 743 VAQIRMAFRYETLCNEL 759
Cdd:cd01319 480 VPQIRMAYRYETLCEEL 496
|
|
| PLN02768 |
PLN02768 |
AMP deaminase |
109-771 |
0e+00 |
|
AMP deaminase
Pssm-ID: 215411 Cd Length: 835 Bit Score: 683.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 109 PAASPAMSPTTpVVTGATSLPTPAPYAM------PE---FQRVTISGdycAGITLEDYEQAAKSLAKALMIREKYARlay 179
Cdd:PLN02768 187 PIPASSMIRSH-SVSGDLHGVQPDPIAAdilrkePEqetFVRLNITP---LEVPSPDEVEAYKVLQECLELRKRYVF--- 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 180 hrfpritsqylghpRADTAPPEEGLPDFHPPPLPQEDPYCLDDAPPNlDYLVHMQGGILFVYDNKkmleHQEPHSLPYPD 259
Cdd:PLN02768 260 --------------REEVAPWEKEIISDPSTPKPNPNPFSYTPEGKS-DHYFEMQDGVVHVYANK----DSKEELFPVAD 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 260 LETYTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKELKSNPHRDFYNVRKVDTHIHAAACMNQKHLL 339
Cdd:PLN02768 321 ATTFFTDLHHILRVIAAGNIRTLCHHRLNLLEQKFNLHLMLNADREFLAQKSAPHRDFYNVRKVDTHVHHSACMNQKHLL 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 340 RFIKHTYQTEPDRTVAEKRGRKITLRQVFDGLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTEN 419
Cdd:PLN02768 401 RFIKSKLRKEPDEVVIFRDGTYLTLKEVFESLDLTGYDLNVDLLDVHADKSTFHRFDKFNLKYNPCGQSRLREIFLKQDN 480
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 420 YLGGEYFARMVKEVARELEESKYQYSEPRLSIYGRSPEEWPNLAYWFIQHKVYSPNMRWIIQVPRIYDIFRSKKLLPNFG 499
Cdd:PLN02768 481 LIQGRFLAELTKQVFSDLEASKYQMAEYRISIYGRKQSEWDQLASWIVNNELYSENVVWLIQLPRLYNVYKEMGIVTSFQ 560
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 500 KMLENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESK----HSDHMfsdksPNPDVWTSEQNPPYSYYLYYMYANI 575
Cdd:PLN02768 561 NILDNIFIPLFEVTVDPDSHPQLHVFLKQVVGLDLVDDESKperrPTKHM-----PTPAQWTNVFNPAFSYYVYYCYANL 635
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 576 MVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKN 655
Cdd:PLN02768 636 YTLNKLRESKGMTTIKFRPHSGEAGDIDHLAATFLTCHNIAHGINLRKSPVLQYLYYLAQIGLAMSPLSNNSLFLDYHRN 715
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 656 PLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYYKEGPEG 735
Cdd:PLN02768 716 PFPMFFLRGLNVSLSTDDPLQIHLTKEPLVEEYSIAASVWKLSSCDLCEIARNSVYQSGFSHALKSHWIGKEYYKRGPDG 795
|
650 660 670
....*....|....*....|....*....|....*...
gi 4502079 736 NDIRKTNVAQIRMAFRYETLCNELS--FLSDAMKSEEI 771
Cdd:PLN02768 796 NDIHKTNVPHIRVEFRDTIWKEEMQqvYLGKAKIPEEV 833
|
|
| PLN03055 |
PLN03055 |
AMP deaminase; Provisional |
155-763 |
0e+00 |
|
AMP deaminase; Provisional
Pssm-ID: 178613 Cd Length: 602 Bit Score: 668.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 155 EDYEQAAKSLAKALMIREKYarlayhrfpritsqyLGHPRadTAPPEEGLPDfHPPPLPQEDPYCLDDAPPNlDYLVHMQ 234
Cdd:PLN03055 6 DEEEEVCAMMQECLELRDKY---------------LFREK--LPPWRKGIFE-SSTSKPNPDPFRYEPEPPS-QHVFRMV 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 235 GGILFVYDNKKMLEHqephSLPYPDLETYTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKELKSNPH 314
Cdd:PLN03055 67 DGVMHVYAPDDAKEE----LFPVPDATTFFTDMHRILRIVSLGNVRTFCHHRLKLLEQKFSLHLMLNADREFLAQKSAPH 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 315 RDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQVFDGLHMDPYDLTVDSLDVHAGRQTFHR 394
Cdd:PLN03055 143 RDFYNVRKVDTHVHHSSCMNQKHLLRFIKSKLRKEPDEVVIFRDGKYLTLREVFESLDLTGYDLNVDLLDVHADKNTFHR 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 395 FDKFNSKYNPVGASELRDLYLKTENYLGGEYFARMVKEVARELEESKYQYSEPRLSIYGRSPEEWPNLAYWFIQHKVYSP 474
Cdd:PLN03055 223 FDKFNLKYNPCGQSRLREIFLKQDNLIQGRFLAELTKEVFSDLEASKYQMAEYRISIYGRKQSEWDQLASWIVNNRLYSE 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 475 NMRWIIQVPRIYDIFRSKKLLPNFGKMLENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESK----HSDHMfsdks 550
Cdd:PLN03055 303 NVVWLIQLPRLYNVYKEMGIVQSFQQILDNIFKPLFEVTVDPSSHPQLHVFLKMVVGFDMVDDESKperrPTKHM----- 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 551 PNPDVWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYL 630
Cdd:PLN03055 378 QTPEQWDIPFNPAYSYWAYYVYANLYTLNKLRESKGLNTIKFRPHAGEAGDIDHLAAAFLLAHNIAHGNNLRKSPGLQYL 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 631 YYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSV 710
Cdd:PLN03055 458 YYLAQIGLAMSPLSNNSLFLDYHRNPFPMFFARGLNVSLSTDDPLQIHLTKEPLVEEYSIAAQVWKLSSCDLCEIARNSV 537
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|...
gi 4502079 711 LQSGLSHQEKQKFLGQNYYKEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLS 763
Cdd:PLN03055 538 LQSGFPHASKKHWVGDNYWLRGPAGNDIHKTNVPHMRVEFRHEVWKEELQYVF 590
|
|
| PTZ00310 |
PTZ00310 |
AMP deaminase; Provisional |
245-763 |
0e+00 |
|
AMP deaminase; Provisional
Pssm-ID: 240354 [Multi-domain] Cd Length: 1453 Bit Score: 562.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 245 KMLEHQEPHSLPypDLETYTVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEF--KELKSNPHRDFYNVRK 322
Cdd:PTZ00310 769 KGAVHAWPRFLP--TLTEFIRDLSELRDICSSVEVKRLATKRLENLEHKFRLHLALNHSNEAgtTEERESSNRDFYQAYK 846
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 323 VDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQVFDGLHMDPyDLTVDSLDVHAGRQTFHRFDKFNSKY 402
Cdd:PTZ00310 847 VDTHIHMAAGMTARQLLEFVVDKLLESGDDIAFKRGDHIVTLGQLFSKYGITP-NLTVDQLNVQADHTLFERFDNFNSKY 925
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 403 NPVGASELRDLYLKTENYLGGEYFARMVKEVARELEESKYQYSEPRLSIYGRSPEEWPNLAYWFIQHKVYSPNMRWIIQV 482
Cdd:PTZ00310 926 NPMENPDLRSLLLKTDNFMKGRYFAELIKDVFEQYSRDRFTYAENRLSIYGINVKEWDDLAHWFDTHGMASKHNKWMIQV 1005
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 483 PRIYDIFRSKKLLPNFGKMLENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESKhSDHMFSDKSPNPdvWTSEQNP 562
Cdd:PTZ00310 1006 PRVYKVFRAQNVIGSFGQYLDNIFQPLWEASLHPSKHPKFHYFLNHVSGFDSVDNEAT-IDLPFTDVSPWA--WTSVENP 1082
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 563 PYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSP 642
Cdd:PTZ00310 1083 PYNYYLYYLYANIRTLNEFRASRGFSTFALRPHCGESGSMDHLYGAFLCANSICHGINLRNDPPMQYLYYLAQIGLHVSP 1162
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 643 LSNNSLFLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQK 722
Cdd:PTZ00310 1163 LSNNALFLAFLENPFPVFFHRGLNVSLSTDDPLMFHQTQEPLIEEYSIAARVWGLSLNDLCEIARNSVLQSGFDAAFKRN 1242
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 4502079 723 FLGQNYYKEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLS 763
Cdd:PTZ00310 1243 AIGDRWYLSSSLGNDSLRTHLSDIRVAFRFETYHTELNFLE 1283
|
|
| PTZ00310 |
PTZ00310 |
AMP deaminase; Provisional |
137-764 |
2.88e-89 |
|
AMP deaminase; Provisional
Pssm-ID: 240354 [Multi-domain] Cd Length: 1453 Bit Score: 307.51 E-value: 2.88e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 137 PEFQRVTISGDYcAGItleDYEQAAKSLAKALMIREKYARLAYHRFpritsqylGHPRADTappeeglpdfhppplpqed 216
Cdd:PTZ00310 63 STMFRVVIDGDD-GGV---DMRKVHGRIAAAIRVRQLYKPTDTKVP--------EGEREQP------------------- 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 217 pyclDDAPPNLDYLvhmqgGILF---VYdnkkMLEHQEPHSLPYPDLETYTVDMSHILALITDGPTKTYCHRRLNFLESK 293
Cdd:PTZ00310 112 ----SDSTPMPSLV-----TIVQrdgVY----RFSGMDTSVVLPPPWEQYVRDVQAVYLTVGNGPCLSACRHRLTIIQER 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 294 FSLHEMLN-EMSEfkelKSNPHRD---FYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQVFd 369
Cdd:PTZ00310 179 SRMFFLLNaEIEE----RADLYKAggvFSPCTKVDNAVLLSTSVDAQELLEFVVTTYREQPRAPLRLRDGSNSTLREYL- 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 370 GLH--MDPYDLTVDSLDVHA--GRQTFHRFDKFNSKyNPVGA--SELRDLYLKTENYLGGEYFARMVKEvaRELEESKYQ 443
Cdd:PTZ00310 254 EAHgvRDPRELTVEGLGWQPtkYRNKYGQYDLFDAK-NPMGAlgAELRQSFLSLHGNLCGKLLRRELER--REYQKQQPQ 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 444 YSEPRLSIYGRSPEEWPNLAYWFIQHKVYS-PNMRWIIQVpriydifRSKKLLPN--------FGKMLENIFLPLFKATI 514
Cdd:PTZ00310 331 ATEYSLPLYGHHPEELTDLAEWVRRQGFGPfSRNRWILAI-------SFKELGPFqvpsscttVQDQLDNIFLPLFKATL 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 515 NPQDHR--ELHLFLKYVTGFdSVDDESKHSDHMFSDKSPNPDVWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLF 592
Cdd:PTZ00310 404 CPSDPQwsDVAWLLCQVGGL-QILTHAVVRSEDFDETAPDPDQVPYTAKCSDLYYFYYVYANLAVLNSLRKRKGLNTLQL 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 593 RPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSL-FLEYSKNPLREFLHKGLHVSLST 671
Cdd:PTZ00310 483 RPSGEKAPAYDQLISSYLLGDVITRATSIADYPVLQYLCGLHRVGLTVSPLRDHALsITAYFDHPLPKFLHRCLRVSIST 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 672 DDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYYKeGPEGNDIRKTNVAQIRMAFR 751
Cdd:PTZ00310 563 SDPLYFHHHSQPLIEEYATAMKLFSLSPLDTTELARNSVLNSSFPPEVKQQWLGERFQL-GVEGNDFERSGVTNYRLAFR 641
|
650
....*....|...
gi 4502079 752 YETLCNELSFLSD 764
Cdd:PTZ00310 642 EEAWALEEALLND 654
|
|
| ADA_AMPD |
cd00443 |
Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic ... |
321-727 |
2.50e-56 |
|
Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase catalyzes a similar reaction leading to the hydrolytic removal of an amino group at the 6 position of the adenine nucleotide ring, a branch point in the adenylate catabolic pathway.
Pssm-ID: 238250 Cd Length: 305 Bit Score: 195.26 E-value: 2.50e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 321 RKVDTHIHAAACMNQKHLLRFIKhtyqtepdrtvaekrgrkitlrqvfdglhmdpydltvdsldvhagrqtfhrfdkfns 400
Cdd:cd00443 2 PKVELHAHLSGSISPETLLELIK--------------------------------------------------------- 24
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 401 kynpvgaSELRDLYLKTENYL-GGEYFARMVKEVARELEESKYQYSEPRLSIYGRSPEE-WPNLAYWFIQHKVYSPNMRW 478
Cdd:cd00443 25 -------KEFFEKFLLVHNLLqKGEALARALKEVIEEFAEDNVQYLELRTTPRLLETEKgLTKEQYWLLVIEGISEAKQW 97
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 479 --IIQVPRIYDIFRSKkllpnfgkmleniflPLFKATINPQDHRELHLFLK-YVTGFDSVDDESKHsdhmfsdkspnpdv 555
Cdd:cd00443 98 fpPIKVRLILSVDRRG---------------PYVQNYLVASEILELAKFLSnYVVGIDLVGDESKG-------------- 148
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 556 wtseQNPPYSYylyymyanIMVLNNLRRergLSTFLFRPHCGEAGSITHLVSAF-LTADNISHGLLLKKSPVLQYLYYLA 634
Cdd:cd00443 149 ----ENPLRDF--------YSYYEYARR---LGLLGLTLHCGETGNREELLQALlLLPDRIGHGIFLLKHPELIYLVKLR 213
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 635 QIPIAMSPLSNNSLFL--EYSKNPLREFLHKGLHVSLSTDDPMQFHYTkeaLMEEYAIAAQVWKLSTCDLCEIARNSVLQ 712
Cdd:cd00443 214 NIPIEVCPTSNVVLGTvqSYEKHPFMRFFKAGLPVSLSTDDPGIFGTS---LSEEYSLAAKTFGLTFEDLCELNRNSVLS 290
|
410
....*....|....*
gi 4502079 713 SGLSHQEKQKFLGQN 727
Cdd:cd00443 291 SFAKDEEKKSLLEVL 305
|
|
| Add |
COG1816 |
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the ... |
583-726 |
2.22e-18 |
|
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 441421 Cd Length: 326 Bit Score: 87.06 E-value: 2.22e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 583 RERGLstfLFRPHCGEAGSITHLVSA--FLTADNISHGLLLKKSPVLqyLYYLA--QIPIAMSPLSNNSL--FLEYSKNP 656
Cdd:COG1816 178 REAGL---HLTAHAGEAGGPESIWEAldLLGAERIGHGVRAIEDPAL--VARLAdrGIPLEVCPTSNVQLgvVPSLAEHP 252
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 657 LREFLHKGLHVSLSTDDPMQFHYTkeaLMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQ 726
Cdd:COG1816 253 LRRLLDAGVRVTLNTDDPLYFGTT---LTDEYELAAEAFGLSDADLAQLARNAIEASFLPEEEKAALLAE 319
|
|
| PRK09358 |
PRK09358 |
adenosine deaminase; Provisional |
583-724 |
1.02e-17 |
|
adenosine deaminase; Provisional
Pssm-ID: 236480 Cd Length: 340 Bit Score: 85.23 E-value: 1.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 583 RERGLstfLFRPHCGEAG---SITHLVsAFLTADNISHGLLLKKSPVLqyLYYLA--QIPIAMSPLSNNSL--FLEYSKN 655
Cdd:PRK09358 192 RDAGL---RLTAHAGEAGgpeSIWEAL-DELGAERIGHGVRAIEDPAL--MARLAdrRIPLEVCPTSNVQTgaVPSLAEH 265
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502079 656 PLREFLHKGLHVSLSTDDPMQFHYTkeaLMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFL 724
Cdd:PRK09358 266 PLKTLLDAGVRVTINTDDPLVFGTT---LTEEYEALAEAFGLSDEDLAQLARNALEAAFLSEEEKAALL 331
|
|
| ADA |
cd01320 |
Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the ... |
583-724 |
1.17e-16 |
|
Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in the purine pathway. Low, as well as high levels of ADA activity have been linked to several diseases.
Pssm-ID: 238645 Cd Length: 325 Bit Score: 81.87 E-value: 1.17e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 583 RERGLStflFRPHCGEAGSITHLVSAF--LTADNISHGLLLKKSPVLqyLYYLA--QIPIAMSPLSNnsLFL----EYSK 654
Cdd:cd01320 183 REAGLR---LTAHAGEAGGPESVRDALdlLGAERIGHGIRAIEDPEL--VKRLAerNIPLEVCPTSN--VQTgavkSLAE 255
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 655 NPLREFLHKGLHVSLSTDDPMQFHYTkeaLMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFL 724
Cdd:cd01320 256 HPLRELLDAGVKVTINTDDPTVFGTY---LTDEYELLAEAFGLTEEELKKLARNAVEASFLSEEEKAELL 322
|
|
| A_deaminase |
pfam00962 |
Adenosine deaminase; |
583-724 |
7.34e-11 |
|
Adenosine deaminase;
Pssm-ID: 425964 Cd Length: 330 Bit Score: 64.37 E-value: 7.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 583 RERGLstfLFRPHCGEAGSITHLVSA--FLTADNISHGLLLKKSPVLqyLYYLA--QIPIAMSPLSN--NSLFLEYSKNP 656
Cdd:pfam00962 185 RDAGL---HLTVHAGEAGGPQSVWEAldDLGAERIGHGVRSAEDPRL--LDRLAdrQIPLEICPTSNvqTGAVASLAEHP 259
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502079 657 LREFLHKGLHVSLSTDDPMQFhytKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFL 724
Cdd:pfam00962 260 LKTFLRAGVPVSLNTDDPLMF---GSDLLDEYQVAKRAPGFDEEELARLAKNAVKGSFLPADEKRALL 324
|
|
| metallo-dependent_hydrolases |
cd01292 |
Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a ... |
591-706 |
1.90e-10 |
|
Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The family includes urease alpha, adenosine deaminase, phosphotriesterase dihydroorotases, allantoinases, hydantoinases, AMP-, adenine and cytosine deaminases, imidazolonepropionase, aryldialkylphosphatase, chlorohydrolases, formylmethanofuran dehydrogenases and others.
Pssm-ID: 238617 [Multi-domain] Cd Length: 275 Bit Score: 62.35 E-value: 1.90e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 591 LFRPHCGEAGSITHLVSAFLTAD------NISHGLLLkkSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSK-NPLREFLHK 663
Cdd:cd01292 148 PVVIHAGELPDPTRALEDLVALLrlggrvVIGHVSHL--DPELLELLKEAGVSLEVCPLSNYLLGRDGEGaEALRRLLEL 225
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 4502079 664 GLHVSLSTDDPmqFHYTKEALMEEYAIAAQVWKL--STCDLCEIA 706
Cdd:cd01292 226 GIRVTLGTDGP--PHPLGTDLLALLRLLLKVLRLglSLEEALRLA 268
|
|
| ADGF |
cd01321 |
Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors ... |
590-724 |
5.74e-08 |
|
Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.
Pssm-ID: 238646 Cd Length: 345 Bit Score: 55.36 E-value: 5.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 590 FLFrpHCGE-AGSIT----HLVSA-FLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSN--NSLFLEYSKNPLREFL 661
Cdd:cd01321 197 FFF--HAGEtNGDGTetdeNLVDAlLLNTKRIGHGFALPKHPLLMDLVKKKNIAIEVCPISNqvLGLVSDLRNHPAAALL 274
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4502079 662 HKGLHVSLSTDDPMQFHYTK------EALMeeyAIAAQVWKLSTcdLCEIARNSVLQSGLSHQEKQKFL 724
Cdd:cd01321 275 ARGVPVVISSDDPGFWGAKGlshdfyQAFM---GLAPADAGLRG--LKQLAENSIRYSALSDQEKDEAV 338
|
|
| PTZ00124 |
PTZ00124 |
adenosine deaminase; Provisional |
583-677 |
2.24e-03 |
|
adenosine deaminase; Provisional
Pssm-ID: 173415 Cd Length: 362 Bit Score: 41.00 E-value: 2.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502079 583 RERGLSTFLfrpHCGEAGSITHLVSAF-----LTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNnsLFLEYSKN-- 655
Cdd:PTZ00124 216 REAGVNLTV---HAGEDVTLPNLNTLYsaiqvLKVKRIGHGIRVAESQELIDMVKEKDILLEVCPISN--VLLNNAKSmd 290
|
90 100
....*....|....*....|....
gi 4502079 656 --PLREFLHKGLHVSLSTDDPMQF 677
Cdd:PTZ00124 291 thPIRKLYDAGVKVSVNSDDPGMF 314
|
|
| |
