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Conserved domains on  [gi|119395746|ref|NP_000207|]
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anosmin-1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cys_box pfam17869
Anosmin cysteine rich domain; This is the Cys-box (cysteine-rich) domain found on the ...
 44-125 3.71e-44

Anosmin cysteine rich domain; This is the Cys-box (cysteine-rich) domain found on the N-terminal of anosmin-1 proteins. It is suggested that the Cys-box domain may resemble the cysteine-rich region of the insulin-like growth factor receptor. Family members are found in chordates.


:

Pssm-ID: 465542  Cd Length: 82  Bit Score: 152.74  E-value: 3.71e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746   44 VQRARCASRCLSLQITRISAFFQHFQNNGSLVWCQNHKQCSKCLEPCKESGDLRKHQCQSFCEPLFPKKSYECLTSCEFL 123
Cdd:pfam17869   1 INRARCASRCLSLHITQITAAFQHFQSNGSLGWCQNHKQCAKCLEPCKESWETRKGLCRKLCEPLFPKKHTECVTSCEFL 80


                  ..
gi 119395746  124 KY 125
Cdd:pfam17869  81 KS 82
WAP smart00217
Four-disulfide core domains;
130-176 4.44e-16

Four-disulfide core domains;


:

Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 72.40  E-value: 4.44e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 119395746   130 KQGDCPAPEKASGFAAACVESCEVDNECSGVKKCCSNGCGHTCQVPK 176
Cdd:smart00217   1 KPGSCPWPTIASCPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
fn3 pfam00041
Fibronectin type III domain;
186-275 1.15e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746  186 PRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRwnygiHPSEDDATHWQTVAQTTDeRVQLTDIRPSRWYQFRVAA 265
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYR-----PKNSGEPWNEITVPGTTT-SVTLTGLKPGTEYEVRVQA 75

                          90
                  ....*....|
gi 119395746  266 VNVHGTRGFT 275
Cdd:pfam00041  76 VNGGGEGPPS 85
COG4733 super family cl34810
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
232-422 1.07e-09

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


The actual alignment was detected with superfamily member COG4733:

Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 61.88  E-value: 1.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746 232 DDATHWQTVAQTTDERVQLTDIRPSRwYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRlansTVNSDGSvtV 311
Cdd:COG4733  573 RDDGNWVSVPRTSGTSFEVPGIYAGD-YEVRVRAINALGVSSAWAASSETTVTGKTAPPPAPTGLT----ATGGLGG--I 645

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746 312 TIVWDLPEEPDIPvhHYKVFWSWMVS-SKSLVPtkkkrrkTTDGFQNSVILEKLQPDCDYvvelqaiTYWGQTRLKSAKV 390
Cdd:COG4733  646 TLSWSFPVDADTL--RTEIRYSTTGDwASATVA-------QALYPGNTYTLAGLKAGQTY-------YYRARAVDRSGNV 709

                        170       180       190
                 ....*....|....*....|....*....|..
gi 119395746 391 SLHFTSTHATNNKEQLVKTRKGGIQTQLPFQR 422
Cdd:COG4733  710 SAWWVSGQASADAAGILDAITGQILETELGQE 741
fn3 pfam00041
Fibronectin type III domain;
550-646 1.78e-07

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.34  E-value: 1.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746  550 KPENLSASFIVQDvniTGHFSWKmAKANLYQPMTGFQVTWAEVTTESRqnslpnsiiSQSQILPSDHYVLTVPNLRPSTL 629
Cdd:pfam00041   2 APSNLTVTDVTST---SLTVSWT-PPPDGNGPITGYEVEYRPKNSGEP---------WNEITVPGTTTSVTLTGLKPGTE 68

                          90
                  ....*....|....*..
gi 119395746  630 YRLEVQVLTPGGEGPAT 646
Cdd:pfam00041  69 YEVRVQAVNGGGEGPPS 85
 
Name Accession Description Interval E-value
Cys_box pfam17869
Anosmin cysteine rich domain; This is the Cys-box (cysteine-rich) domain found on the ...
 44-125 3.71e-44

Anosmin cysteine rich domain; This is the Cys-box (cysteine-rich) domain found on the N-terminal of anosmin-1 proteins. It is suggested that the Cys-box domain may resemble the cysteine-rich region of the insulin-like growth factor receptor. Family members are found in chordates.


Pssm-ID: 465542  Cd Length: 82  Bit Score: 152.74  E-value: 3.71e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746   44 VQRARCASRCLSLQITRISAFFQHFQNNGSLVWCQNHKQCSKCLEPCKESGDLRKHQCQSFCEPLFPKKSYECLTSCEFL 123
Cdd:pfam17869   1 INRARCASRCLSLHITQITAAFQHFQSNGSLGWCQNHKQCAKCLEPCKESWETRKGLCRKLCEPLFPKKHTECVTSCEFL 80


                  ..
gi 119395746  124 KY 125
Cdd:pfam17869  81 KS 82
WAP smart00217
Four-disulfide core domains;
130-176 4.44e-16

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 72.40  E-value: 4.44e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 119395746   130 KQGDCPAPEKASGFAAACVESCEVDNECSGVKKCCSNGCGHTCQVPK 176
Cdd:smart00217   1 KPGSCPWPTIASCPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 111-176 1.80e-15

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 70.94  E-value: 1.80e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119395746 111 KKSYECLTSCEFLKyillVKQGDCPAPEKASgfAAACVESCEVDNECSGVKKCCSNGCGHTCQVPK 176
Cdd:cd00199    1 GNNMTKPGSCPRPV----EKPGRCPMVNPPS--LGIPPNRCSSDSDCPGDKKCCENGCGKSCLTPV 60
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 130-175 1.09e-11

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 59.75  E-value: 1.09e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 119395746  130 KQGDCPAPekasGFAAACVESCEVDNECSGVKKCCSNGCGHTCQVP 175
Cdd:pfam00095   1 KPGCCPRL----GARGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
fn3 pfam00041
Fibronectin type III domain;
186-275 1.15e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746  186 PRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRwnygiHPSEDDATHWQTVAQTTDeRVQLTDIRPSRWYQFRVAA 265
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYR-----PKNSGEPWNEITVPGTTT-SVTLTGLKPGTEYEVRVQA 75

                          90
                  ....*....|
gi 119395746  266 VNVHGTRGFT 275
Cdd:pfam00041  76 VNGGGEGPPS 85
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
232-422 1.07e-09

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 61.88  E-value: 1.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746 232 DDATHWQTVAQTTDERVQLTDIRPSRwYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRlansTVNSDGSvtV 311
Cdd:COG4733  573 RDDGNWVSVPRTSGTSFEVPGIYAGD-YEVRVRAINALGVSSAWAASSETTVTGKTAPPPAPTGLT----ATGGLGG--I 645

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746 312 TIVWDLPEEPDIPvhHYKVFWSWMVS-SKSLVPtkkkrrkTTDGFQNSVILEKLQPDCDYvvelqaiTYWGQTRLKSAKV 390
Cdd:COG4733  646 TLSWSFPVDADTL--RTEIRYSTTGDwASATVA-------QALYPGNTYTLAGLKAGQTY-------YYRARAVDRSGNV 709

                        170       180       190
                 ....*....|....*....|....*....|..
gi 119395746 391 SLHFTSTHATNNKEQLVKTRKGGIQTQLPFQR 422
Cdd:COG4733  710 SAWWVSGQASADAAGILDAITGQILETELGQE 741
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
173-333 2.04e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 60.79  E-value: 2.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746 173 QVPKTLYKGVPLKPrKELRFTELQSGQLEVKWSSKFNISIEPviYVVQRrwnygihpSEDDATHWQTVAQTTDERVQLTD 252
Cdd:COG3401  223 EVSVTTPTTPPSAP-TGLTATADTPGSVTLSWDPVTESDATG--YRVYR--------SNSGDGPFTKVATVTTTSYTDTG 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746 253 IRPSRWYQFRVAAVNVHGTRGftAPSKHFRSSKDPSAPPAPANLRlanSTVNSDGSVTVTivWDLPEEPDipVHHYKVFW 332
Cdd:COG3401  292 LTNGTTYYYRVTAVDAAGNES--APSNVVSVTTDLTPPAAPSGLT---ATAVGSSSITLS--WTASSDAD--VTGYNVYR 362


                 .
gi 119395746 333 S 333
Cdd:COG3401  363 S 363
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 290-381 3.10e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 3.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746 290 PPAPANLRLansTVNSDGSVTVTivWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTtdgfqnSVILEKLQPDCD 369
Cdd:cd00063    1 PSPPTNLRV---TDVTSTSVTLS--WTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET------SYTLTGLKPGTE 69

                         90
                 ....*....|..
gi 119395746 370 YVVELQAITYWG 381
Cdd:cd00063   70 YEFRVRAVNGGG 81
fn3 pfam00041
Fibronectin type III domain;
291-378 1.34e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.34  E-value: 1.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746  291 PAPANLRLansTVNSDGSVTVTivWDLPEEPDIPVHHYKVFWsWMVSSkslvpTKKKRRKTTDGFQNSVILEKLQPDCDY 370
Cdd:pfam00041   1 SAPSNLTV---TDVTSTSLTVS--WTPPPDGNGPITGYEVEY-RPKNS-----GEPWNEITVPGTTTSVTLTGLKPGTEY 69


                  ....*...
gi 119395746  371 VVELQAIT 378
Cdd:pfam00041  70 EVRVQAVN 77
fn3 pfam00041
Fibronectin type III domain;
550-646 1.78e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.34  E-value: 1.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746  550 KPENLSASFIVQDvniTGHFSWKmAKANLYQPMTGFQVTWAEVTTESRqnslpnsiiSQSQILPSDHYVLTVPNLRPSTL 629
Cdd:pfam00041   2 APSNLTVTDVTST---SLTVSWT-PPPDGNGPITGYEVEYRPKNSGEP---------WNEITVPGTTTSVTLTGLKPGTE 68

                          90
                  ....*....|....*..
gi 119395746  630 YRLEVQVLTPGGEGPAT 646
Cdd:pfam00041  69 YEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 183-271 1.18e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.11  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746 183 PLKPRKeLRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRwnygihpsEDDATHWQTV--AQTTDERVQLTDIRPSRWYQ 260
Cdd:cd00063    1 PSPPTN-LRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYR--------EKGSGDWKEVevTPGSETSYTLTGLKPGTEYE 71

                         90
                 ....*....|.
gi 119395746 261 FRVAAVNVHGT 271
Cdd:cd00063   72 FRVRAVNGGGE 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 290-382 5.60e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 5.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746   290 PPAPANLRLANSTVNSdgsvtVTIVWDLPEEPDI--PVHHYKVFWSWMVSSKSLVPTKKKrrkttdgfQNSVILEKLQPD 367
Cdd:smart00060   1 PSPPSNLRVTDVTSTS-----VTLSWEPPPDDGItgYIVGYRVEYREEGSEWKEVNVTPS--------STSYTLTGLKPG 67

                           90
                   ....*....|....*
gi 119395746   368 CDYVVELQAITYWGQ 382
Cdd:smart00060  68 TEYEFRVRAVNGAGE 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 183-270 2.31e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 2.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746   183 PLKPRKeLRFTELQSGQLEVKWS-SKFNISIEPVIYvvqrrwnYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQF 261
Cdd:smart00060   1 PSPPSN-LRVTDVTSTSVTLSWEpPPDDGITGYIVG-------YRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72


                   ....*....
gi 119395746   262 RVAAVNVHG 270
Cdd:smart00060  73 RVRAVNGAG 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 550-652 9.47e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.02  E-value: 9.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746 550 KPENLSASFIVQD-VNItghfSWKMAKANLYQPmTGFQVTWAEVTTESRQNSLPNSIISQSqilpsdhyvLTVPNLRPST 628
Cdd:cd00063    3 PPTNLRVTDVTSTsVTL----SWTPPEDDGGPI-TGYVVEYREKGSGDWKEVEVTPGSETS---------YTLTGLKPGT 68

                         90       100
                 ....*....|....*....|....*
gi 119395746 629 LYRLEVQVLTPGGEG-PATIKTFRT 652
Cdd:cd00063   69 EYEFRVRAVNGGGESpPSESVTVTT 93
 
Name Accession Description Interval E-value
Cys_box pfam17869
Anosmin cysteine rich domain; This is the Cys-box (cysteine-rich) domain found on the ...
 44-125 3.71e-44

Anosmin cysteine rich domain; This is the Cys-box (cysteine-rich) domain found on the N-terminal of anosmin-1 proteins. It is suggested that the Cys-box domain may resemble the cysteine-rich region of the insulin-like growth factor receptor. Family members are found in chordates.


Pssm-ID: 465542  Cd Length: 82  Bit Score: 152.74  E-value: 3.71e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746   44 VQRARCASRCLSLQITRISAFFQHFQNNGSLVWCQNHKQCSKCLEPCKESGDLRKHQCQSFCEPLFPKKSYECLTSCEFL 123
Cdd:pfam17869   1 INRARCASRCLSLHITQITAAFQHFQSNGSLGWCQNHKQCAKCLEPCKESWETRKGLCRKLCEPLFPKKHTECVTSCEFL 80


                  ..
gi 119395746  124 KY 125
Cdd:pfam17869  81 KS 82
WAP smart00217
Four-disulfide core domains;
130-176 4.44e-16

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 72.40  E-value: 4.44e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 119395746   130 KQGDCPAPEKASGFAAACVESCEVDNECSGVKKCCSNGCGHTCQVPK 176
Cdd:smart00217   1 KPGSCPWPTIASCPLGNPPNKCSSDSQCPGVKKCCFNGCGKSCLTPV 47
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 111-176 1.80e-15

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 70.94  E-value: 1.80e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119395746 111 KKSYECLTSCEFLKyillVKQGDCPAPEKASgfAAACVESCEVDNECSGVKKCCSNGCGHTCQVPK 176
Cdd:cd00199    1 GNNMTKPGSCPRPV----EKPGRCPMVNPPS--LGIPPNRCSSDSDCPGDKKCCENGCGKSCLTPV 60
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 130-175 1.09e-11

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 59.75  E-value: 1.09e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 119395746  130 KQGDCPAPekasGFAAACVESCEVDNECSGVKKCCSNGCGHTCQVP 175
Cdd:pfam00095   1 KPGCCPRL----GARGCCRSCCSSDDDCPGRQKCCSNGCGSVCVPP 42
fn3 pfam00041
Fibronectin type III domain;
186-275 1.15e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746  186 PRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRwnygiHPSEDDATHWQTVAQTTDeRVQLTDIRPSRWYQFRVAA 265
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYR-----PKNSGEPWNEITVPGTTT-SVTLTGLKPGTEYEVRVQA 75

                          90
                  ....*....|
gi 119395746  266 VNVHGTRGFT 275
Cdd:pfam00041  76 VNGGGEGPPS 85
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
232-422 1.07e-09

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 61.88  E-value: 1.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746 232 DDATHWQTVAQTTDERVQLTDIRPSRwYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRlansTVNSDGSvtV 311
Cdd:COG4733  573 RDDGNWVSVPRTSGTSFEVPGIYAGD-YEVRVRAINALGVSSAWAASSETTVTGKTAPPPAPTGLT----ATGGLGG--I 645

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746 312 TIVWDLPEEPDIPvhHYKVFWSWMVS-SKSLVPtkkkrrkTTDGFQNSVILEKLQPDCDYvvelqaiTYWGQTRLKSAKV 390
Cdd:COG4733  646 TLSWSFPVDADTL--RTEIRYSTTGDwASATVA-------QALYPGNTYTLAGLKAGQTY-------YYRARAVDRSGNV 709

                        170       180       190
                 ....*....|....*....|....*....|..
gi 119395746 391 SLHFTSTHATNNKEQLVKTRKGGIQTQLPFQR 422
Cdd:COG4733  710 SAWWVSGQASADAAGILDAITGQILETELGQE 741
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
173-333 2.04e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 60.79  E-value: 2.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746 173 QVPKTLYKGVPLKPrKELRFTELQSGQLEVKWSSKFNISIEPviYVVQRrwnygihpSEDDATHWQTVAQTTDERVQLTD 252
Cdd:COG3401  223 EVSVTTPTTPPSAP-TGLTATADTPGSVTLSWDPVTESDATG--YRVYR--------SNSGDGPFTKVATVTTTSYTDTG 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746 253 IRPSRWYQFRVAAVNVHGTRGftAPSKHFRSSKDPSAPPAPANLRlanSTVNSDGSVTVTivWDLPEEPDipVHHYKVFW 332
Cdd:COG3401  292 LTNGTTYYYRVTAVDAAGNES--APSNVVSVTTDLTPPAAPSGLT---ATAVGSSSITLS--WTASSDAD--VTGYNVYR 362


                 .
gi 119395746 333 S 333
Cdd:COG3401  363 S 363
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 290-381 3.10e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 3.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746 290 PPAPANLRLansTVNSDGSVTVTivWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTtdgfqnSVILEKLQPDCD 369
Cdd:cd00063    1 PSPPTNLRV---TDVTSTSVTLS--WTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSET------SYTLTGLKPGTE 69

                         90
                 ....*....|..
gi 119395746 370 YVVELQAITYWG 381
Cdd:cd00063   70 YEFRVRAVNGGG 81
fn3 pfam00041
Fibronectin type III domain;
291-378 1.34e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.34  E-value: 1.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746  291 PAPANLRLansTVNSDGSVTVTivWDLPEEPDIPVHHYKVFWsWMVSSkslvpTKKKRRKTTDGFQNSVILEKLQPDCDY 370
Cdd:pfam00041   1 SAPSNLTV---TDVTSTSLTVS--WTPPPDGNGPITGYEVEY-RPKNS-----GEPWNEITVPGTTTSVTLTGLKPGTEY 69


                  ....*...
gi 119395746  371 VVELQAIT 378
Cdd:pfam00041  70 EVRVQAVN 77
fn3 pfam00041
Fibronectin type III domain;
550-646 1.78e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.34  E-value: 1.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746  550 KPENLSASFIVQDvniTGHFSWKmAKANLYQPMTGFQVTWAEVTTESRqnslpnsiiSQSQILPSDHYVLTVPNLRPSTL 629
Cdd:pfam00041   2 APSNLTVTDVTST---SLTVSWT-PPPDGNGPITGYEVEYRPKNSGEP---------WNEITVPGTTTSVTLTGLKPGTE 68

                          90
                  ....*....|....*..
gi 119395746  630 YRLEVQVLTPGGEGPAT 646
Cdd:pfam00041  69 YEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 183-271 1.18e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.11  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746 183 PLKPRKeLRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRwnygihpsEDDATHWQTV--AQTTDERVQLTDIRPSRWYQ 260
Cdd:cd00063    1 PSPPTN-LRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYR--------EKGSGDWKEVevTPGSETSYTLTGLKPGTEYE 71

                         90
                 ....*....|.
gi 119395746 261 FRVAAVNVHGT 271
Cdd:cd00063   72 FRVRAVNGGGE 82
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
208-333 4.01e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.00  E-value: 4.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746 208 FNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTTDERVQLTD----IRPSRWYQFRVAAVNVHGTRgftAPSKHFRS 283
Cdd:COG3401  150 VDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDgggdIEPGTTYYYRVAATDTGGES---APSNEVSV 226

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 119395746 284 SKDPSAPPAPANLRlanSTVNSDGSVTVTivWDLPEEPDipVHHYKVFWS 333
Cdd:COG3401  227 TTPTTPPSAPTGLT---ATADTPGSVTLS--WDPVTESD--ATGYRVYRS 269
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 290-382 5.60e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.91  E-value: 5.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746   290 PPAPANLRLANSTVNSdgsvtVTIVWDLPEEPDI--PVHHYKVFWSWMVSSKSLVPTKKKrrkttdgfQNSVILEKLQPD 367
Cdd:smart00060   1 PSPPSNLRVTDVTSTS-----VTLSWEPPPDDGItgYIVGYRVEYREEGSEWKEVNVTPS--------STSYTLTGLKPG 67

                           90
                   ....*....|....*
gi 119395746   368 CDYVVELQAITYWGQ 382
Cdd:smart00060  68 TEYEFRVRAVNGAGE 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 183-270 2.31e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 2.31e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746   183 PLKPRKeLRFTELQSGQLEVKWS-SKFNISIEPVIYvvqrrwnYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQF 261
Cdd:smart00060   1 PSPPSN-LRVTDVTSTSVTLSWEpPPDDGITGYIVG-------YRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72


                   ....*....
gi 119395746   262 RVAAVNVHG 270
Cdd:smart00060  73 RVRAVNGAG 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 550-652 9.47e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.02  E-value: 9.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119395746 550 KPENLSASFIVQD-VNItghfSWKMAKANLYQPmTGFQVTWAEVTTESRQNSLPNSIISQSqilpsdhyvLTVPNLRPST 628
Cdd:cd00063    3 PPTNLRVTDVTSTsVTL----SWTPPEDDGGPI-TGYVVEYREKGSGDWKEVEVTPGSETS---------YTLTGLKPGT 68

                         90       100
                 ....*....|....*....|....*
gi 119395746 629 LYRLEVQVLTPGGEG-PATIKTFRT 652
Cdd:cd00063   69 EYEFRVRAVNGGGESpPSESVTVTT 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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