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Conserved domains on  [gi|119393899|ref|NP_000159|]
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transcriptional activator GLI3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 542-632 8.27e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.10  E-value: 8.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119393899  542 GEKPHKCTFEGCTKAYSRLENLKTHLRshtgekpyvceHEGCNKAFSNASDRAKHQNRTHSNeKPYVCkiPGCTKRYTDP 621
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHML-----------HGHQNQKLHENPSPEKMNIFSAKD-KPYRC--EVCDKRYKNL 411

                          90
                  ....*....|.
gi 119393899  622 SSLRKHVKTVH 632
Cdd:COG5189   412 NGLKYHRKHSH 422
 
Name Accession Description Interval E-value
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 542-632 8.27e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.10  E-value: 8.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119393899  542 GEKPHKCTFEGCTKAYSRLENLKTHLRshtgekpyvceHEGCNKAFSNASDRAKHQNRTHSNeKPYVCkiPGCTKRYTDP 621
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHML-----------HGHQNQKLHENPSPEKMNIFSAKD-KPYRC--EVCDKRYKNL 411

                          90
                  ....*....|.
gi 119393899  622 SSLRKHVKTVH 632
Cdd:COG5189   412 NGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
532-559 6.36e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 6.36e-05
                           10        20
                   ....*....|....*....|....*...
gi 119393899   532 MLVVHMRRHTGEKPHKCTFegCTKAYSR 559
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Name Accession Description Interval E-value
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 542-632 8.27e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.10  E-value: 8.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119393899  542 GEKPHKCTFEGCTKAYSRLENLKTHLRshtgekpyvceHEGCNKAFSNASDRAKHQNRTHSNeKPYVCkiPGCTKRYTDP 621
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHML-----------HGHQNQKLHENPSPEKMNIFSAKD-KPYRC--EVCDKRYKNL 411

                          90
                  ....*....|.
gi 119393899  622 SSLRKHVKTVH 632
Cdd:COG5189   412 NGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
532-559 6.36e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 6.36e-05
                           10        20
                   ....*....|....*....|....*...
gi 119393899   532 MLVVHMRRHTGEKPHKCTFegCTKAYSR 559
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
562-589 7.97e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 7.97e-05
                           10        20
                   ....*....|....*....|....*...
gi 119393899   562 NLKTHLRSHTGEKPYVCEHegCNKAFSN 589
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
551-624 6.38e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 6.38e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119393899  551 EGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNaSDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSL 624
Cdd:COG5048    37 PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSR-PLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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