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Conserved domains on  [gi|108796736|ref|YP_636566|]
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beta subunit of RNA polymerase (chloroplast) [Zygnema circumcarinatum]

Protein Classification

DNA-directed RNA polymerase subunit beta( domain architecture ID 11413981)

DNA-directed RNA polymerase subunit beta catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
rpoB CHL00001
RNA polymerase beta subunit
2-1054 0e+00

RNA polymerase beta subunit


:

Pssm-ID: 214330 [Multi-domain]  Cd Length: 1070  Bit Score: 1807.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736    2 LSINRNAGMFVLPDFKQIQIDSFRHFLTDLLRLELQRFGTIKHANQQLEFKLLGELYRLEIPKFNEREAVYQSATYSSNL 81
Cdd:CHL00001    1 MLRDGNEGMSTIPGFNQIQFEGFCRFIDQGLTEELSKFPKIEDTDQEIEFQLFVETYQLVEPLIKERDAVYESLTYSSEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   82 YAPAYLVDKKRGIIQKQTVFLGSIPLMSARGTFVIRGVSRCIVSQLLRSPGIYYT--LSVQG--VYTATIICNSGKSFKL 157
Cdd:CHL00001   81 YVPAGLIWKKSRDMQEQTVFIGNIPLMNSLGTFIINGIYRVVINQILRSPGIYYRseLDHNGisVYTGTIISDWGGRLEL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  158 ELDRQGCLWVRVGRNSKAPLLLLLIALGLEMRYI------PPMIVQR-TKKLNQLLLCVEDAKIDLCKRLKlkqkttqIE 230
Cdd:CHL00001  161 EIDRKARIWARVSRKQKISILVLLSAMGLNLREIldnvcyPEIFLSFlNDKEKKKIGSKENAILEFYQQFA-------CV 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  231 LGvtDPIYS----------LFLKPYELGRMGRLNLNKRLNLRVSEFEILLRSQDLIVASDYLVQVSNGIGSLDDIDDLKH 300
Cdd:CHL00001  234 GG--DPVFSeslckelqkkFFQQRCELGRIGRRNMNRKLNLDIPENNTFLLPQDVLAAADYLIGMKFGMGTLDDIDHLKN 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  301 KRVKWVSDLFCVQLNMALKKLNVAVHTNLNKMEARISRMSLKSVVSSNAIATTFFRFVASYQLSQFLDQTNPLSEIVHKR 380
Cdd:CHL00001  312 KRIRSVADLLQDQFGLALNRLENAVRGTICGAIRRKLIPTPQNLVTSTPLTTTYESFFGSHPLSQFLDQTNPLTEIVHGR 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  381 KLSLLGPGGLTPRTARFRVRDIHPSQYGRICPVQTAEGQNAGVVNSFTICAHIGDNGAIKTSLYKVCTNSMQGHVIDMLP 460
Cdd:CHL00001  392 KLSSLGPGGLTGRTASFRVRDIHPSHYGRICPIDTSEGINAGLIGSLAIHARIGHWGSLESPFYEISERSKEERMVYLSP 471
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  461 GEDEYSTIATESCLVVANSSNQFQSIPAQHRREFVTLRWDEIGFRNTLPVHSFSVGVVLIPFLEHDDATRALMGSNMQRQ 540
Cdd:CHL00001  472 SEDEYYMIAAGNSLALNQGIQEEQVVPARYRQEFLTIAWEQIHLRSIFPFQYFSIGASLIPFLEHNDANRALMGSNMQRQ 551
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  541 AVPLLKLERPIVGTGIESQVALDSGTVITAVQECKIHNVDATQIAYVPKDsfELLYINLLNYERSNNATCLHQRPIVECG 620
Cdd:CHL00001  552 AVPLSRSEKCIVGTGLERQVALDSGVVAIAEHEGKIIYTDTDKIILSGNG--DTLSIPLVMYQRSNKNTCMHQKPQVRRG 629
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  621 ETVQKGQLIADGSATVDGELALGKNVLVAYMPWEGYNFEDAVLINERLIYEDVYTSLHIERYEAEARETNQAIETITKQI 700
Cdd:CHL00001  630 KCVKKGQILADGAATVGGELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDIYTSFHIRKYEIQTHVTSQGPERITKEI 709
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  701 PHLNAHVLRHLDETGVVSLGAWVETGDVLVGKLTAKQSEGLLHTPESKLLQDILGVQAFGTQDTCLKVPTRGEGRVIDVR 780
Cdd:CHL00001  710 PHLEAHLLRNLDKNGIVMLGSWVETGDILVGKLTPQEAEESSYAPEGRLLRAIFGIQVSTSKETCLKLPIGGRGRVIDVR 789
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  781 WITRDNHLLGHRKVIHVYILQERKIQVGDKVAGRHGNKGVVSRILPRQDMPYLQDGTPVDMVLSPLGVPSRMNVGQVFEC 860
Cdd:CHL00001  790 WIQKKGGSSYNPETIHVYILQKREIQVGDKVAGRHGNKGIISKILPRQDMPYLQDGTPVDMVLNPLGVPSRMNVGQIFEC 869
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  861 LLGLAGGYLNQHYRIMPFDERYGRESSRKLVFSELYKASQTTNYPWIFEPDSPGKSRLFDGRTGEVFNQPVTVGRAYMFK 940
Cdd:CHL00001  870 LLGLAGDLLNRHYRIAPFDERYEQEASRKLVFSELYEASKQTANPWVFEPEYPGKSRLFDGRTGDPFEQPVTIGKAYILK 949
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  941 LIHQVDDKIHARSTGPYALVTQQPVRGRSRQGGQRVGEMEVWAFQGFGAACVLQELLTTKSDHATARAEAPNAIVTGNLV 1020
Cdd:CHL00001  950 LIHQVDDKIHARSSGPYALVTQQPLRGRSKQGGQRVGEMEVWALEGFGVAYILQEMLTYKSDHIRARQEVLGAIITGGTI 1029
                        1050      1060      1070
                  ....*....|....*....|....*....|....
gi 108796736 1021 PKPIGTSDCLGVLIRELQCLGIQLDHTMLSQHNM 1054
Cdd:CHL00001 1030 PKPEDAPESFRLLVRELRSLALELNHFLVSEKNF 1063
 
Name Accession Description Interval E-value
rpoB CHL00001
RNA polymerase beta subunit
2-1054 0e+00

RNA polymerase beta subunit


Pssm-ID: 214330 [Multi-domain]  Cd Length: 1070  Bit Score: 1807.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736    2 LSINRNAGMFVLPDFKQIQIDSFRHFLTDLLRLELQRFGTIKHANQQLEFKLLGELYRLEIPKFNEREAVYQSATYSSNL 81
Cdd:CHL00001    1 MLRDGNEGMSTIPGFNQIQFEGFCRFIDQGLTEELSKFPKIEDTDQEIEFQLFVETYQLVEPLIKERDAVYESLTYSSEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   82 YAPAYLVDKKRGIIQKQTVFLGSIPLMSARGTFVIRGVSRCIVSQLLRSPGIYYT--LSVQG--VYTATIICNSGKSFKL 157
Cdd:CHL00001   81 YVPAGLIWKKSRDMQEQTVFIGNIPLMNSLGTFIINGIYRVVINQILRSPGIYYRseLDHNGisVYTGTIISDWGGRLEL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  158 ELDRQGCLWVRVGRNSKAPLLLLLIALGLEMRYI------PPMIVQR-TKKLNQLLLCVEDAKIDLCKRLKlkqkttqIE 230
Cdd:CHL00001  161 EIDRKARIWARVSRKQKISILVLLSAMGLNLREIldnvcyPEIFLSFlNDKEKKKIGSKENAILEFYQQFA-------CV 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  231 LGvtDPIYS----------LFLKPYELGRMGRLNLNKRLNLRVSEFEILLRSQDLIVASDYLVQVSNGIGSLDDIDDLKH 300
Cdd:CHL00001  234 GG--DPVFSeslckelqkkFFQQRCELGRIGRRNMNRKLNLDIPENNTFLLPQDVLAAADYLIGMKFGMGTLDDIDHLKN 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  301 KRVKWVSDLFCVQLNMALKKLNVAVHTNLNKMEARISRMSLKSVVSSNAIATTFFRFVASYQLSQFLDQTNPLSEIVHKR 380
Cdd:CHL00001  312 KRIRSVADLLQDQFGLALNRLENAVRGTICGAIRRKLIPTPQNLVTSTPLTTTYESFFGSHPLSQFLDQTNPLTEIVHGR 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  381 KLSLLGPGGLTPRTARFRVRDIHPSQYGRICPVQTAEGQNAGVVNSFTICAHIGDNGAIKTSLYKVCTNSMQGHVIDMLP 460
Cdd:CHL00001  392 KLSSLGPGGLTGRTASFRVRDIHPSHYGRICPIDTSEGINAGLIGSLAIHARIGHWGSLESPFYEISERSKEERMVYLSP 471
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  461 GEDEYSTIATESCLVVANSSNQFQSIPAQHRREFVTLRWDEIGFRNTLPVHSFSVGVVLIPFLEHDDATRALMGSNMQRQ 540
Cdd:CHL00001  472 SEDEYYMIAAGNSLALNQGIQEEQVVPARYRQEFLTIAWEQIHLRSIFPFQYFSIGASLIPFLEHNDANRALMGSNMQRQ 551
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  541 AVPLLKLERPIVGTGIESQVALDSGTVITAVQECKIHNVDATQIAYVPKDsfELLYINLLNYERSNNATCLHQRPIVECG 620
Cdd:CHL00001  552 AVPLSRSEKCIVGTGLERQVALDSGVVAIAEHEGKIIYTDTDKIILSGNG--DTLSIPLVMYQRSNKNTCMHQKPQVRRG 629
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  621 ETVQKGQLIADGSATVDGELALGKNVLVAYMPWEGYNFEDAVLINERLIYEDVYTSLHIERYEAEARETNQAIETITKQI 700
Cdd:CHL00001  630 KCVKKGQILADGAATVGGELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDIYTSFHIRKYEIQTHVTSQGPERITKEI 709
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  701 PHLNAHVLRHLDETGVVSLGAWVETGDVLVGKLTAKQSEGLLHTPESKLLQDILGVQAFGTQDTCLKVPTRGEGRVIDVR 780
Cdd:CHL00001  710 PHLEAHLLRNLDKNGIVMLGSWVETGDILVGKLTPQEAEESSYAPEGRLLRAIFGIQVSTSKETCLKLPIGGRGRVIDVR 789
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  781 WITRDNHLLGHRKVIHVYILQERKIQVGDKVAGRHGNKGVVSRILPRQDMPYLQDGTPVDMVLSPLGVPSRMNVGQVFEC 860
Cdd:CHL00001  790 WIQKKGGSSYNPETIHVYILQKREIQVGDKVAGRHGNKGIISKILPRQDMPYLQDGTPVDMVLNPLGVPSRMNVGQIFEC 869
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  861 LLGLAGGYLNQHYRIMPFDERYGRESSRKLVFSELYKASQTTNYPWIFEPDSPGKSRLFDGRTGEVFNQPVTVGRAYMFK 940
Cdd:CHL00001  870 LLGLAGDLLNRHYRIAPFDERYEQEASRKLVFSELYEASKQTANPWVFEPEYPGKSRLFDGRTGDPFEQPVTIGKAYILK 949
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  941 LIHQVDDKIHARSTGPYALVTQQPVRGRSRQGGQRVGEMEVWAFQGFGAACVLQELLTTKSDHATARAEAPNAIVTGNLV 1020
Cdd:CHL00001  950 LIHQVDDKIHARSSGPYALVTQQPLRGRSKQGGQRVGEMEVWALEGFGVAYILQEMLTYKSDHIRARQEVLGAIITGGTI 1029
                        1050      1060      1070
                  ....*....|....*....|....*....|....
gi 108796736 1021 PKPIGTSDCLGVLIRELQCLGIQLDHTMLSQHNM 1054
Cdd:CHL00001 1030 PKPEDAPESFRLLVRELRSLALELNHFLVSEKNF 1063
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
13-1042 0e+00

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 1019.98  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736    13 LPDFKQIQIDSFRHFLTDL----------LRLELQRFGTIKHANQQLEFKLLGelYRLEIPKFNEREAVYQSATYSSNLY 82
Cdd:TIGR02013   17 VPNLLEIQLDSYDWFLQQDtppekrkeegLEEVFKSIFPIEDYTGNIELEYLS--YRLGEPKYSVEECKERGLTYSAPLK 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736    83 APAYLVDKKR---GIIQKQTVFLGSIPLMSARGTFVIRGVSRCIVSQLLRSPGIYYTLSV------QGVYTATIICNSGK 153
Cdd:TIGR02013   95 VKLRLINKEEdgtKEIKEQDVYMGDIPLMTDRGTFIINGAERVVVSQLHRSPGVFFSSEKdttksgKVLFSARIIPYRGS 174
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   154 SFKLELDRQGCLWVRVGRNSKAPLLLLLIALGLEMRYI-------PPMIvqRTKKLNQLLLCVEDAKIDLCKRLKLKQKT 226
Cdd:TIGR02013  175 WLEFETDKKDVLYVRIDRKRKLPATVLLRALGYTIDTLilnrlgsGEYI--RNTLRKDPTNSEEEALVEIYRKLRPGEPP 252
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   227 TqIELGVTDpIYSLFLKP--YELGRMGRLNLNKRLNLRVSEFEILLRSQDLIVASDYLVQVSNGIGSLDDIDDLKHKRVK 304
Cdd:TIGR02013  253 T-VEAARSL-LENLFFDPkrYDLGRVGRYKLNKKLGLDVPESIGVLTKEDIIATIKYLIKLRNGKGEIDDIDHLGNRRIR 330
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   305 WVSDLFCVQlnmalkklnvaVHTNLNKMEARI-SRMSLKSV--------VSSNAIATTFFRFVASYQLSQFLDQTNPLSE 375
Cdd:TIGR02013  331 SVGELLQNQ-----------FRVGLARMERIVrERMSTQDTdtltpqdlINAKPISAAIKEFFGSSQLSQFMDQTNPLAE 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   376 IVHKRKLSLLGPGGLTPRTARFRVRDIHPSQYGRICPVQTAEGQNAGVVNSFTICAHIGDNGAIKTSLYKVCTNSMQGH- 454
Cdd:TIGR02013  400 LTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLSTYARVNEYGFIETPYRKVKDGKVVVTd 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   455 VIDMLPGEDEYS-TIATESCLVVANSSNQFQSIPAQHRREFVTLRWDEIGFRNTLPVHSFSVGVVLIPFLEHDDATRALM 533
Cdd:TIGR02013  480 EIDYLTADEEDNyVIAQANAPLDENGRFVEDLVVARYRGEITLVSPDQVDYMDVSPKQVVSVAASLIPFLEHDDANRALM 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   534 GSNMQRQAVPLLKLERPIVGTGIESQVALDSGTVITAVQECKIHNVDATQI------AYVPKDSFELLYiNLLNYERSNN 607
Cdd:TIGR02013  560 GSNMQRQAVPLLRSEAPLVGTGMEAKVARDSGAVIVAKRGGVVEYVDAKRIvirydeDEEEPDGGIDIY-RLLKYQRSNQ 638
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   608 ATCLHQRPIVECGETVQKGQLIADGSATVDGELALGKNVLVAYMPWEGYNFEDAVLINERLIYEDVYTSLHIERYEAEAR 687
Cdd:TIGR02013  639 DTCINQRPIVSVGDRVEAGDVLADGPSTDLGELALGRNVLVAFMPWNGYNYEDAILISERLVKDDVFTSIHIEEYEVEAR 718
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   688 ETNQAIETITKQIPHLNAHVLRHLDETGVVSLGAWVETGDVLVGKLTAKqSEGLLhTPESKLLQDILGVQAFGTQDTCLK 767
Cdd:TIGR02013  719 DTKLGPEEITRDIPNVSEEALRNLDENGIVRIGAEVKAGDILVGKVTPK-GETEL-TPEEKLLRAIFGEKARDVRDTSLR 796
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   768 VPTRGEGRVIDVRWITR---DNHLLGHRKVIHVYILQERKIQVGDKVAGRHGNKGVVSRILPRQDMPYLQDGTPVDMVLS 844
Cdd:TIGR02013  797 VPPGVEGTVIDVKVFSReqgDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSKILPIEDMPFLEDGTPVDIVLN 876
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   845 PLGVPSRMNVGQVFECLLGLAGGYLNQHyrimpfderyGRESSRKLVFSELYKASQTTNYPWIFEPDspGKSRLFDGRTG 924
Cdd:TIGR02013  877 PLGVPSRMNIGQILETHLGWAGKRLGRK----------GVPIATPVFDGASEEEIKEYLEKAGLPRD--GKVRLYDGRTG 944
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   925 EVFNQPVTVGRAYMFKLIHQVDDKIHARSTGPYALVTQQPVRGRSRQGGQRVGEMEVWAFQGFGAACVLQELLTTKSDHA 1004
Cdd:TIGR02013  945 EQFDRPVTVGYMYMLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDV 1024
                         1050      1060      1070
                   ....*....|....*....|....*....|....*...
gi 108796736  1005 TARAEAPNAIVTGNLVPKPiGTSDCLGVLIRELQCLGI 1042
Cdd:TIGR02013 1025 VGRTKAYEAIVKGENVPEP-GIPESFNVLIKELQSLGL 1061
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
13-1042 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 1000.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   13 LPDFKQIQIDSFRHFLTDLLRLELQRFGTIKHANQQLEFKLLGelYRLEIPKFNEREAVYQSATYSSNLYAPAYLVDKKR 92
Cdd:COG0085    13 LPNLLEIQLDSFNWFLEEGLQEIFDEISPIEDFTGNLSLEFGD--YRLGEPKYTPEECKERDLTYAAPLYVKVRLVNKET 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   93 GIIQKQTVFLGSIPLMSARGTFVIRGVSRCIVSQLLRSPGIYYT----LSVQGVYTATIICNSGKSFKLELDRQGCLWVR 168
Cdd:COG0085    91 GEIKEQEVFMGDFPLMTDSGTFIINGTERVIVSQLVRSPGVYFVeeedKSGKDLYSAKVIPSRGAWLEFETDKDGTIYVR 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  169 VGRNSKAPLL--------------LLLIALGLEMRYIPPMIVQRTKKLnqlllcVEDAKIDLCKRLKLKQKTTqIELGVT 234
Cdd:COG0085   171 IDRKRKIPVTvllralgletdeeiLEAFGDDPIQEYILATLEKDNTKT------QEEALLEIYRKLRPGEPPT-IERAEQ 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  235 DpIYSLFLKP--YELGRMGRLNLNKRLNLRVSEFEILLRSQDLIVASDYLVQVSNGIGSLDDIDDLKHKRVKWVSDLFCV 312
Cdd:COG0085   244 L-LDNLFFDPkrYDLAHVGRYKINKKLGLDVPPEDRVLTAEDIVATIKYLLELHLGEREPDDIDHLGNRRVRLVGELLQN 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  313 QLNMALKKLNVAVHTNLNKMEARisRMSLKSVVSSNAIATTFFRFVASYQLSQFLDQTNPLSEIVHKRKLSLLGPGGLTP 392
Cdd:COG0085   323 QFRVGLSRMERVVRERMTTQDVE--AITPQSLINIRPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLSR 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  393 RTARFRVRDIHPSQYGRICPVQTAEGQNAGVVNSFTICAHIGDNGAIKTSLYKVCTnsmqGHV---IDML-PGEDEYSTI 468
Cdd:COG0085   401 ERAGFEVRDVHPSHYGRMCPIETPEGPNIGLIGSLALYARVNEYGFIETPYRKVEN----GKVtdeIEYLtADEEENYYI 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  469 ATESCLVVANSSNQFQSIPAQHRREFVTLRWDEIGFRNTLPVHSFSVGVVLIPFLEHDDATRALMGSNMQRQAVPLLKLE 548
Cdd:COG0085   477 AQANAPLDEDGNFLEERVLVRYRGEEVLVPPEEVDYMDVSPKQIVSVATSLIPFLEHDDANRALMGANMQRQAVPLLRPE 556
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  549 RPivgtgiesqvaldsgtvitavqeckihnvdatqiayvpkdsfeLLYINLLNYERSNNATCLHQRPIVECGETVQKGQL 628
Cdd:COG0085   557 AP-------------------------------------------LLHYPLQKFQRSNQGTCINQRPIVRVGDRVEKGDV 593
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  629 IADGSATVDGELALGKNVLVAYMPWEGYNFEDAVLINERLIYEDVYTSLHIERYEAEARETNQAIETITKQIPHLNAHVL 708
Cdd:COG0085   594 LADGPATDNGELALGQNLLVAFMPWEGYNYEDAIIISERLVKDDVLTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEAL 673
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  709 RHLDETGVVSLGAWVETGDVLVGKLTAKqSEGLLhTPESKLLQDILGVQAFGTQDTCLKVPTRGEGRVIDVRWITRDN-- 786
Cdd:COG0085   674 RNLDEDGIIRIGAEVKGGDILVGKVTPK-GETEL-TPEERLLRAIFGEKAREVRDTSLRVPHGEKGKVIDVKVFSREEgd 751
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  787 -HLLGHRKVIHVYILQERKIQVGDKVAGRHGNKGVVSRILPRQDMPYLQDGTPVDMVLSPLGVPSRMNVGQVFECLLGLA 865
Cdd:COG0085   752 eLPPGVNKLVRVYVAQKRKIEVGDKLAGRHGNKGVISRILPQEDMPFLEDGTPVDIVLNPLGVPSRMNVGQVLETHLGWA 831
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  866 GGYLNQHYRIMPFDERYGREssrklVFSELYKAsqttnypwIFEPDspGKSRLFDGRTGEVFNQPVTVGRAYMFKLIHQV 945
Cdd:COG0085   832 AALLGRRVATPVFDGAPEEE-----IRELLEKA--------GLPPD--GKEVLYDGRTGEPFDNPVTVGYMYYLKLHHMV 896
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  946 DDKIHARSTGPYALVTQQPVRGRSRQGGQRVGEMEVWAFQGFGAACVLQELLTTKSDHATARAEAPNAIVTGNLVPKPiG 1025
Cdd:COG0085   897 DDKIHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQERLTIKSDDVCGRVKVYEAIVKGENIPEP-G 975
                        1050
                  ....*....|....*..
gi 108796736 1026 TSDCLGVLIRELQCLGI 1042
Cdd:COG0085   976 IPESFKVLLKELQSLGL 992
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
18-1042 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 763.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   18 QIQIDSFRHFLTDLLRLELQRFGTIKHANQQLEFKLLGELYRLEIPKFNE---------REAVYQSATYSSNLYAPAYLV 88
Cdd:cd00653     3 KQQIDSFNYFLNVGLQEIVKSIPPITDTDDDGRLKLKFGDIYLGKPKVEEggvtrkltpNECRLRDLTYSAPLYVDIRLT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   89 DKKRGIIQKQTVFLGSIPLM------------------------SARGTFVIRGVSRCIVSQLLRSPGIYYTLSVQG--V 142
Cdd:cd00653    83 VNDKGKIKEQEVFIGEIPIMlrsklcnlngltpeeliklgecplDPGGYFIINGTEKVIINQEQRSPNVIIVEDSKGkrI 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  143 YTATIICNSGKSFKLELDrqgclwvrvgrnskaplllllialglemryippmivqrtkklnqlllcvedakidlckrLKL 222
Cdd:cd00653   163 YTKTSIPSYSPYRGSWLE-----------------------------------------------------------VKS 183
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  223 KQKTTQIELgvtdpiyslflkpyelgrmgRLNLNKRLNLRvseFEILLRSQDLIVASDYLVQVSNGIGSLDDIDDLKHKR 302
Cdd:cd00653   184 DKKKDRIYV--------------------RIDLKRQEEAL---KYIGKRFEDLIYMIRKLILLVLGKGKLDDIDHLGNKR 240
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  303 VKWVSDLFCVQLNMALKKLNVAVHTNLNKMEARISRMSLKSVVSSNAIATTFFRFVASYQ------------LSQFLDQT 370
Cdd:cd00653   241 VRLAGELLQNLFRSGLKRLEREVKEKLQKQLSKKKDLTPQLLINSKPITSGIKEFLATGNwgskrflmqrsgLSQVLDRL 320
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  371 NPLSEIVHKRKLSllgPGGLTPRTARFRVRDIHPSQYGRICPVQTAEGQNAGVVNSFTICAHIgdNGAIKTSLYKVctns 450
Cdd:cd00653   321 NPLSELSHKRRIS---SLGLFRERKGFEVRDLHPSHWGRICPIETPEGENCGLVKNLALMARI--SGRIERPYRIV---- 391
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  451 mqghvidmlpgedeystiatesclvvanssnqfqsipaqhrREFVTLRwdEIGfrntlPVHSFSVGVVLIPFLEHDDATR 530
Cdd:cd00653   392 -----------------------------------------EKEVTHI--EIS-----PSQILSVAASLIPFPEHNQSPR 423
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  531 ALMGSNMQRQAVP----------------LLKLERPIVGTGIESQVALDsgtvitavqeckihnvdatqiayvpkdsfel 594
Cdd:cd00653   424 NLYQSNMQKQAVGtpalnqqyrmdtklylLLYPQKPLVGTGIEEYIAFG------------------------------- 472
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  595 lyinllnyersnnatclhqrpivecgetvqkgqliadgsatvdgELALGKNVLVAYMPWEGYNFEDAVLINERLIYEDVY 674
Cdd:cd00653   473 --------------------------------------------ELPLGQNAIVAVMSYSGYNFEDAIIINKSSVDRGFF 508
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  675 TSLHIERYEAEARETNQAIETITK-QIPHLNAHVLRHLDETGVVSLGAWVETGDVLVGKLTAKQSEGLLHtpeskllqdI 753
Cdd:cd00653   509 RSIHYKKYEIELRKTKNGPEEITRgDIPNVSEEKLKNLDEDGIIRPGARVEPGDILVGKITPKGETESTP---------I 579
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  754 LGVQAFGTQDTCLKVPTRGEGRVIDVRWITRDNhLLGHRKVIHVYILQERKIQVGDKVAGRHGNKGVVSRILPRQDMPYL 833
Cdd:cd00653   580 FGEKARDVRDTSLKYPGGEKGIVDDVKIFSREL-NDGGNKLVKVYIRQKRKPQIGDKFASRHGQKGVISKILPQEDMPFT 658
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  834 QDGTPVDMVLSPLGVPSRMNVGQVFECLLGLAGGYLNQHYRIMPFDERYGRESSRKLVFSELykasqttNYPwifepdsp 913
Cdd:cd00653   659 EDGIPPDIILNPHGFPSRMTIGQLLESLLGKAGALLGKFGDATPFDGAEEEDISELLGEAGL-------NYY-------- 723
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  914 GKSRLFDGRTGEVFNQPVTVGRAYMFKLIHQVDDKIHARSTGPYALVTQQPVRGRSRQGGQRVGEMEVWAFQGFGAACVL 993
Cdd:cd00653   724 GKEVLYDGRTGEPLEAPIFVGPVYYQRLKHMVDDKIHARSTGPYSLLTRQPLKGRSRGGGQRFGEMERDALIAHGAAYLL 803
                        1050      1060      1070      1080      1090
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 108796736  994 QELLTTKSDHATARAEAPNAIV-TGNLVPKPIGTSDC--------LGVLIRELQCLGI 1042
Cdd:cd00653   804 QERLTIKSDDVVARVCVKCGIIlSANLCRLCKKGTNIskvgipyaFKLLFQELQSMNI 861
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
519-970 1.40e-134

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 411.15  E-value: 1.40e-134
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   519 LIPFLEHDDATRALMGSNMQRQAVpllklerpivgtGIesqvaldsgtvitavqeckihnvdatqiayvpkdsfellyIN 598
Cdd:pfam00562    4 LIPFVDHNQSPRNTYQCAMGKQAM------------GI----------------------------------------YT 31
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   599 LLNYERSNNAT---CLHQRPIVECGeTVQKGQLiadgsatvdGELALGKNVLVAYMPWEGYNFEDAVLINERLIYEDVYT 675
Cdd:pfam00562   32 LNKFYRSDQNTyvlCYPQKPLVKTG-AVEAGGF---------GELPLGQNAIVAVMSYTGYNQEDAIIINKSSVDRGFFT 101
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   676 SLHIERYEAEaRETNQAIETITKQIPHLNAHVLRHLDETGVVSLGAWVETGDVLVGKLTAkqsegllhTPESKLLQDILG 755
Cdd:pfam00562  102 SIHIKEIEAR-KTKLGPIEEITRDIPNVSEEALKKLDEDGIVRVGAEVKPGDILVGKVGP--------TELTKLLRAIFG 172
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   756 VQAFGTQDTCLKVPTRGEGRVIDVRWITRDNHllGHRKVIhVYILQERKIQVGDKVAGRHGNKGVVSRILPRQDMPYLQD 835
Cdd:pfam00562  173 EKARDVKDTSLKVPPGEEGVVDDVIVFELPPG--GIKMVK-VYIRQKRKPEVGDKFASRHGQKGVVSRILPQEDMPFTED 249
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   836 GTPVDMVLSPLGVPSRMNVGQVFECLLGLAGGYLNQHYRIMPFDeryGRESSRKLVFSELYKASqttnypwiFEPDspGK 915
Cdd:pfam00562  250 GIPPDIILNPHGVPSRMTIGQLLETHLGKAAALLGVFVDATPFD---GASTEVEDIGELLEKAG--------YNYY--GK 316
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 108796736   916 SRLFDGRTGEVFNQPVTVGRAYMFKLIHQVDDKIHARSTGPYALVTQQPVRGRSR 970
Cdd:pfam00562  317 EVLYDGRTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGPYSLLTRQPLGGRAR 371
 
Name Accession Description Interval E-value
rpoB CHL00001
RNA polymerase beta subunit
2-1054 0e+00

RNA polymerase beta subunit


Pssm-ID: 214330 [Multi-domain]  Cd Length: 1070  Bit Score: 1807.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736    2 LSINRNAGMFVLPDFKQIQIDSFRHFLTDLLRLELQRFGTIKHANQQLEFKLLGELYRLEIPKFNEREAVYQSATYSSNL 81
Cdd:CHL00001    1 MLRDGNEGMSTIPGFNQIQFEGFCRFIDQGLTEELSKFPKIEDTDQEIEFQLFVETYQLVEPLIKERDAVYESLTYSSEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   82 YAPAYLVDKKRGIIQKQTVFLGSIPLMSARGTFVIRGVSRCIVSQLLRSPGIYYT--LSVQG--VYTATIICNSGKSFKL 157
Cdd:CHL00001   81 YVPAGLIWKKSRDMQEQTVFIGNIPLMNSLGTFIINGIYRVVINQILRSPGIYYRseLDHNGisVYTGTIISDWGGRLEL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  158 ELDRQGCLWVRVGRNSKAPLLLLLIALGLEMRYI------PPMIVQR-TKKLNQLLLCVEDAKIDLCKRLKlkqkttqIE 230
Cdd:CHL00001  161 EIDRKARIWARVSRKQKISILVLLSAMGLNLREIldnvcyPEIFLSFlNDKEKKKIGSKENAILEFYQQFA-------CV 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  231 LGvtDPIYS----------LFLKPYELGRMGRLNLNKRLNLRVSEFEILLRSQDLIVASDYLVQVSNGIGSLDDIDDLKH 300
Cdd:CHL00001  234 GG--DPVFSeslckelqkkFFQQRCELGRIGRRNMNRKLNLDIPENNTFLLPQDVLAAADYLIGMKFGMGTLDDIDHLKN 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  301 KRVKWVSDLFCVQLNMALKKLNVAVHTNLNKMEARISRMSLKSVVSSNAIATTFFRFVASYQLSQFLDQTNPLSEIVHKR 380
Cdd:CHL00001  312 KRIRSVADLLQDQFGLALNRLENAVRGTICGAIRRKLIPTPQNLVTSTPLTTTYESFFGSHPLSQFLDQTNPLTEIVHGR 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  381 KLSLLGPGGLTPRTARFRVRDIHPSQYGRICPVQTAEGQNAGVVNSFTICAHIGDNGAIKTSLYKVCTNSMQGHVIDMLP 460
Cdd:CHL00001  392 KLSSLGPGGLTGRTASFRVRDIHPSHYGRICPIDTSEGINAGLIGSLAIHARIGHWGSLESPFYEISERSKEERMVYLSP 471
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  461 GEDEYSTIATESCLVVANSSNQFQSIPAQHRREFVTLRWDEIGFRNTLPVHSFSVGVVLIPFLEHDDATRALMGSNMQRQ 540
Cdd:CHL00001  472 SEDEYYMIAAGNSLALNQGIQEEQVVPARYRQEFLTIAWEQIHLRSIFPFQYFSIGASLIPFLEHNDANRALMGSNMQRQ 551
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  541 AVPLLKLERPIVGTGIESQVALDSGTVITAVQECKIHNVDATQIAYVPKDsfELLYINLLNYERSNNATCLHQRPIVECG 620
Cdd:CHL00001  552 AVPLSRSEKCIVGTGLERQVALDSGVVAIAEHEGKIIYTDTDKIILSGNG--DTLSIPLVMYQRSNKNTCMHQKPQVRRG 629
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  621 ETVQKGQLIADGSATVDGELALGKNVLVAYMPWEGYNFEDAVLINERLIYEDVYTSLHIERYEAEARETNQAIETITKQI 700
Cdd:CHL00001  630 KCVKKGQILADGAATVGGELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDIYTSFHIRKYEIQTHVTSQGPERITKEI 709
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  701 PHLNAHVLRHLDETGVVSLGAWVETGDVLVGKLTAKQSEGLLHTPESKLLQDILGVQAFGTQDTCLKVPTRGEGRVIDVR 780
Cdd:CHL00001  710 PHLEAHLLRNLDKNGIVMLGSWVETGDILVGKLTPQEAEESSYAPEGRLLRAIFGIQVSTSKETCLKLPIGGRGRVIDVR 789
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  781 WITRDNHLLGHRKVIHVYILQERKIQVGDKVAGRHGNKGVVSRILPRQDMPYLQDGTPVDMVLSPLGVPSRMNVGQVFEC 860
Cdd:CHL00001  790 WIQKKGGSSYNPETIHVYILQKREIQVGDKVAGRHGNKGIISKILPRQDMPYLQDGTPVDMVLNPLGVPSRMNVGQIFEC 869
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  861 LLGLAGGYLNQHYRIMPFDERYGRESSRKLVFSELYKASQTTNYPWIFEPDSPGKSRLFDGRTGEVFNQPVTVGRAYMFK 940
Cdd:CHL00001  870 LLGLAGDLLNRHYRIAPFDERYEQEASRKLVFSELYEASKQTANPWVFEPEYPGKSRLFDGRTGDPFEQPVTIGKAYILK 949
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  941 LIHQVDDKIHARSTGPYALVTQQPVRGRSRQGGQRVGEMEVWAFQGFGAACVLQELLTTKSDHATARAEAPNAIVTGNLV 1020
Cdd:CHL00001  950 LIHQVDDKIHARSSGPYALVTQQPLRGRSKQGGQRVGEMEVWALEGFGVAYILQEMLTYKSDHIRARQEVLGAIITGGTI 1029
                        1050      1060      1070
                  ....*....|....*....|....*....|....
gi 108796736 1021 PKPIGTSDCLGVLIRELQCLGIQLDHTMLSQHNM 1054
Cdd:CHL00001 1030 PKPEDAPESFRLLVRELRSLALELNHFLVSEKNF 1063
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
13-1042 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 1073.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   13 LPDFKQIQIDSFRHFLTDL-------LRLELQRFGTIKHANQQLEFKLLGelYRLEIPKFNEREAVYQSATYSSNLYAPA 85
Cdd:PRK00405   24 LPNLLEIQLDSFDWFLQLDvppedegLEEVFRSIFPIEDFNGNLSLEFVS--YELGEPKYDVEECKERGLTYSAPLRVKL 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   86 YLVDKKRGIIQKQTVFLGSIPLMSARGTFVIRGVSRCIVSQLLRSPGIYY------TLSVQGVYTATIICNSGKSFKLEL 159
Cdd:PRK00405  102 RLINKETGEIKEQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPGVYFdhdkdkTSSGKLLYSARIIPYRGSWLEFEF 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  160 DRQGCLWVRVGRNSKAP---------------------LLLLLIALGLEMRYIPPMIVQRTKKLNQ--LLLCVEDAKIDL 216
Cdd:PRK00405  182 DPKDILYVRIDRRRKLPvtvllralgysdeeildlfyeKEEFGKEIEVPVEYLLGKVLAEDIVDEEtgEVLAEANDEITE 261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  217 CKRLKLKQKTTQIELGVT---------------DP---------IYSLFLKP--YELGRMGRLNLNKRLNLRVSEFEILL 270
Cdd:PRK00405  262 ELDGPYIRNTLEKDPTSSreealveiyrrlrpgEPptveaarslLENLFFDPkrYDLSKVGRYKLNKKLGLDEDEDVRVL 341
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  271 RSQDLIVASDYLVQVSNGIGSLDDIDDLKHKRVKWVSDLFCVQlnmalkklnvaVHTNLNKMEaRI--SRMSL------- 341
Cdd:PRK00405  342 TKEDIIATIKYLINLRNGKGEVDDIDHLGNRRVRSVGELLQNQ-----------FRIGLSRME-RAvrERMSLqdldtlt 409
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  342 -KSVVSSNAIATTFFRFVASYQLSQFLDQTNPLSEIVHKRKLSLLGPGGLTPRTARFRVRDIHPSQYGRICPVQTAEGQN 420
Cdd:PRK00405  410 pQDLINAKPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPN 489
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  421 AGVVNSFTICAHIGDNGAIKTSLYKVcTNsmqGHVIDmlpgEDEYSTIATESCLVVA------NSSNQF--QSIPAQHRR 492
Cdd:PRK00405  490 IGLINSLATYARVNEYGFIETPYRKV-VD---GKVTD----EIVYLTADEEDNYVIAqanaplDEDGRFvdELVTARYKG 561
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  493 EFVTLRWDEIGFRNTLPVHSFSVGVVLIPFLEHDDATRALMGSNMQRQAVPLLKLERPIVGTGIESQVALDSGTVITAVQ 572
Cdd:PRK00405  562 EFVLVPPEEVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRPEAPLVGTGMERRVARDSGAVVVAKR 641
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  573 ECKIHNVDATQI--AYVPKDSFEL---LYiNLLNYERSNNATCLHQRPIVECGETVQKGQLIADGSATVDGELALGKNVL 647
Cdd:PRK00405  642 DGVVEYVDASRIvvRVEELDPGEDgvdIY-NLIKFQRSNQNTCINQRPIVKVGDRVEKGDVLADGPSTDNGELALGQNVL 720
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  648 VAYMPWEGYNFEDAVLINERLIYEDVYTSLHIERYEAEARETNQAIETITKQIPHLNAHVLRHLDETGVVSLGAWVETGD 727
Cdd:PRK00405  721 VAFMPWNGYNFEDAILISERLVKEDVFTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDESGIVRIGAEVKPGD 800
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  728 VLVGKLTAKqSEGLLhTPESKLLQDILGVQAFGTQDTCLKVPTRGEGRVIDVRWITR----DNhlL--GHRKVIHVYILQ 801
Cdd:PRK00405  801 ILVGKVTPK-GETEL-TPEEKLLRAIFGEKARDVKDTSLRVPHGEEGTVIDVKVFTRieqgDE--LppGVNKLVKVYIAQ 876
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  802 ERKIQVGDKVAGRHGNKGVVSRILPRQDMPYLQDGTPVDMVLSPLGVPSRMNVGQVFECLLGLAGGYLNQHYRIMPFDER 881
Cdd:PRK00405  877 KRKIQVGDKMAGRHGNKGVVSRILPVEDMPYLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWAAKGLGIKFATPVFDGA 956
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  882 YGREssrklVFSELYKASqttnypwifePDSPGKSRLFDGRTGEVFNQPVTVGRAYMFKLIHQVDDKIHARSTGPYALVT 961
Cdd:PRK00405  957 KEEE-----IKELLEEAG----------LPEDGKTTLYDGRTGEPFDRPVTVGYMYMLKLHHLVDDKIHARSTGPYSLVT 1021
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  962 QQPVRGRSRQGGQRVGEMEVWAFQGFGAACVLQELLTTKSDHATARAEAPNAIVTGNLVPKPiGTSDCLGVLIRELQCLG 1041
Cdd:PRK00405 1022 QQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKVYEAIVKGENIPEP-GIPESFNVLVKELQSLG 1100

                  .
gi 108796736 1042 I 1042
Cdd:PRK00405 1101 L 1101
rpoB CHL00207
RNA polymerase beta subunit; Provisional
10-1044 0e+00

RNA polymerase beta subunit; Provisional


Pssm-ID: 214397 [Multi-domain]  Cd Length: 1077  Bit Score: 1038.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   10 MFVLPDFKQIQIDSFRHFLTDLLRLELQRFGTIKHANQQLEFKLLGELYRLEIPKFNEREAVYQSATYSSNLYAPAYLVD 89
Cdd:CHL00207    4 NFALPDFLEIQRTSFCWFLNEGLNEELNIFSKIFDYTGNLELLLFGKNYKLKYPKYNLLSAKSYDSNYSIQIYLPLKFIN 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   90 KKRGIIQKQTVFLGSIPLMSARGTFVIRGVSRCIVSQLLRSPGIYYTLSV----QGVYTATIICNSGKSFKLELDRQGCL 165
Cdd:CHL00207   84 LKTNKIKFINYLIGNLPKMTQRGTFIINGLERVIVSQIIRSPGIYFKKEIkknsNKIYSATLIPNRGSWIKFELDKNKEI 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  166 WVRVGRNSKAPLLLLLIALGLEMRYI-PPMIVQRTKKLNQLLLCV------EDAKIDLCKRLKLKQKTTQieLGVTDPIY 238
Cdd:CHL00207  164 WIRIDKNRKKPLIIFLKALGLTDQDIySRLTKSEFLKKLKPILLNsnsytnEEILLEIYKNLSPIEPATV--NDANQNLF 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  239 SLFLKP--YELGRMGRLNLNKRLNLRVSEFEILLRSQDLIVASDYLVQVSNGIGSLDDIDDLKHKRVKWVSDLFCVQLNM 316
Cdd:CHL00207  242 SRFFDPknYDLGKVGRYKINNKLNLNIPERVRNLTYEDILSIIDKLINLKINKGNFDDIDHLKNRRVRSVGELLQNQFRI 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  317 ALKKLNVAVHTNLNKMEarISRMSLKSVVSSNAIATTFFRFVASYQLSQFLDQTNPLSEIVHKRKLSLLGPGGLTPRTAR 396
Cdd:CHL00207  322 GLKRLERILRNRMTICD--IDSLSKFNLINPKPLIALIREFFGSSQLSQYMDQTNPLSELTHKRRISILGPGGLDKDRIS 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  397 FRVRDIHPSQYGRICPVQTAEGQNAGVVNSFTICAHIGDNGAIKTSLYKVCTNSMQGHV----IDMLPgEDEYStIATES 472
Cdd:CHL00207  400 FAVRDIHPSHYGRICPIETPEGPNCGLIGSLATNARINKFGFIETPFYKVINGKVKKFGnpiyLTADS-EDLYR-IAPND 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  473 CLVVANSSNQFQSIPAQHRREFVTLRWDEIGFRNTLPVHSFSVGVVLIPFLEHDDATRALMGSNMQRQAVPLLKLERPIV 552
Cdd:CHL00207  478 INLNKNNYFKKNIIPVRYKQEFKTVNPSKVDFIAISPIQVFSIAESLIPFLEHNDANRALMGSNMQRQAVPLLYPEKPIV 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  553 GTGIESQVALDSGTVITAVQECKIHNVDATQIAYVPKDSFELLYiNLLNYERSNNATCLHQRPIVECGETVQKGQLIADG 632
Cdd:CHL00207  558 GTGYEKQIALDSGMTIISLTEGIVVSVSAYKIIIQDDNNRYIHY-YLQKYQRSNQNTCINYRPIVWVGEKINIGQILADG 636
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  633 SATVDGELALGKNVLVAYMPWEGYNFEDAVLINERLIYEDVYTSLHIERYEAEARETNQAIETITKQIPHLNAHVLRHLD 712
Cdd:CHL00207  637 SDIDNSELALGQNVLVAYMPWEGYNFEDAILINKRLVYEDLFTSIHIEKYEIELRQTKLGSEEITRNIPNVSEYSLKNLD 716
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  713 ETGVVSLGAWVETGDVLVGKLTAKQSEGLLhtPESKLLQDILGVQAFGTQDTCLKVPTRGEGRVIDVRWITR---DNHLL 789
Cdd:CHL00207  717 ENGIISIGSKVLAGDILVGKITPKGESDQL--PEGKLLRAIFGEKAKDVKDTSLRMPNGGYGRVIKVEIFSRskgDELKF 794
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  790 GHRKVIHVYILQERKIQVGDKVAGRHGNKGVVSRILPRQDMPYLQDGTPVDMVLSPLGVPSRMNVGQVFECLLGLAGGYL 869
Cdd:CHL00207  795 GYYLKIRVFIAQIRKIQVGDKLAGRHGNKGIISRILPRQDMPYLPDGTPPDIILNPLGVPSRMNVGQLFECLLGLAGDNL 874
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  870 NQHYRIMPFDERYGRESSRKLVFSELYKASQTTNYPWIFEPDSPGKSRLFDGRTGEVFNQPVTVGRAYMFKLIHQVDDKI 949
Cdd:CHL00207  875 NKRFKILPFDEMYGSEYSRILINNKLNQASIKNNEYWLFNSYHPGKMVLRDGRTGYKFKNPVTVGIAYMLKLIHLVDDKI 954
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  950 HARSTGPYALVTQQPVRGRSRQGGQRVGEMEVWAFQGFGAACVLQELLTTKSDHATARAEAPNAIVTGNLVPKPiGTSDC 1029
Cdd:CHL00207  955 HARTTGPYSLVTQQPLGGKAQHGGQRFGEMEVWALEAFGAAYTLKELLTIKSDDMQGRNETLNAIVKGQPIPKP-GTPES 1033
                        1050
                  ....*....|....*
gi 108796736 1030 LGVLIRELQCLGIQL 1044
Cdd:CHL00207 1034 FKVLMRELQSLGLDI 1048
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
13-1042 0e+00

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 1019.98  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736    13 LPDFKQIQIDSFRHFLTDL----------LRLELQRFGTIKHANQQLEFKLLGelYRLEIPKFNEREAVYQSATYSSNLY 82
Cdd:TIGR02013   17 VPNLLEIQLDSYDWFLQQDtppekrkeegLEEVFKSIFPIEDYTGNIELEYLS--YRLGEPKYSVEECKERGLTYSAPLK 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736    83 APAYLVDKKR---GIIQKQTVFLGSIPLMSARGTFVIRGVSRCIVSQLLRSPGIYYTLSV------QGVYTATIICNSGK 153
Cdd:TIGR02013   95 VKLRLINKEEdgtKEIKEQDVYMGDIPLMTDRGTFIINGAERVVVSQLHRSPGVFFSSEKdttksgKVLFSARIIPYRGS 174
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   154 SFKLELDRQGCLWVRVGRNSKAPLLLLLIALGLEMRYI-------PPMIvqRTKKLNQLLLCVEDAKIDLCKRLKLKQKT 226
Cdd:TIGR02013  175 WLEFETDKKDVLYVRIDRKRKLPATVLLRALGYTIDTLilnrlgsGEYI--RNTLRKDPTNSEEEALVEIYRKLRPGEPP 252
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   227 TqIELGVTDpIYSLFLKP--YELGRMGRLNLNKRLNLRVSEFEILLRSQDLIVASDYLVQVSNGIGSLDDIDDLKHKRVK 304
Cdd:TIGR02013  253 T-VEAARSL-LENLFFDPkrYDLGRVGRYKLNKKLGLDVPESIGVLTKEDIIATIKYLIKLRNGKGEIDDIDHLGNRRIR 330
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   305 WVSDLFCVQlnmalkklnvaVHTNLNKMEARI-SRMSLKSV--------VSSNAIATTFFRFVASYQLSQFLDQTNPLSE 375
Cdd:TIGR02013  331 SVGELLQNQ-----------FRVGLARMERIVrERMSTQDTdtltpqdlINAKPISAAIKEFFGSSQLSQFMDQTNPLAE 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   376 IVHKRKLSLLGPGGLTPRTARFRVRDIHPSQYGRICPVQTAEGQNAGVVNSFTICAHIGDNGAIKTSLYKVCTNSMQGH- 454
Cdd:TIGR02013  400 LTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLSTYARVNEYGFIETPYRKVKDGKVVVTd 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   455 VIDMLPGEDEYS-TIATESCLVVANSSNQFQSIPAQHRREFVTLRWDEIGFRNTLPVHSFSVGVVLIPFLEHDDATRALM 533
Cdd:TIGR02013  480 EIDYLTADEEDNyVIAQANAPLDENGRFVEDLVVARYRGEITLVSPDQVDYMDVSPKQVVSVAASLIPFLEHDDANRALM 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   534 GSNMQRQAVPLLKLERPIVGTGIESQVALDSGTVITAVQECKIHNVDATQI------AYVPKDSFELLYiNLLNYERSNN 607
Cdd:TIGR02013  560 GSNMQRQAVPLLRSEAPLVGTGMEAKVARDSGAVIVAKRGGVVEYVDAKRIvirydeDEEEPDGGIDIY-RLLKYQRSNQ 638
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   608 ATCLHQRPIVECGETVQKGQLIADGSATVDGELALGKNVLVAYMPWEGYNFEDAVLINERLIYEDVYTSLHIERYEAEAR 687
Cdd:TIGR02013  639 DTCINQRPIVSVGDRVEAGDVLADGPSTDLGELALGRNVLVAFMPWNGYNYEDAILISERLVKDDVFTSIHIEEYEVEAR 718
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   688 ETNQAIETITKQIPHLNAHVLRHLDETGVVSLGAWVETGDVLVGKLTAKqSEGLLhTPESKLLQDILGVQAFGTQDTCLK 767
Cdd:TIGR02013  719 DTKLGPEEITRDIPNVSEEALRNLDENGIVRIGAEVKAGDILVGKVTPK-GETEL-TPEEKLLRAIFGEKARDVRDTSLR 796
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   768 VPTRGEGRVIDVRWITR---DNHLLGHRKVIHVYILQERKIQVGDKVAGRHGNKGVVSRILPRQDMPYLQDGTPVDMVLS 844
Cdd:TIGR02013  797 VPPGVEGTVIDVKVFSReqgDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSKILPIEDMPFLEDGTPVDIVLN 876
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   845 PLGVPSRMNVGQVFECLLGLAGGYLNQHyrimpfderyGRESSRKLVFSELYKASQTTNYPWIFEPDspGKSRLFDGRTG 924
Cdd:TIGR02013  877 PLGVPSRMNIGQILETHLGWAGKRLGRK----------GVPIATPVFDGASEEEIKEYLEKAGLPRD--GKVRLYDGRTG 944
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   925 EVFNQPVTVGRAYMFKLIHQVDDKIHARSTGPYALVTQQPVRGRSRQGGQRVGEMEVWAFQGFGAACVLQELLTTKSDHA 1004
Cdd:TIGR02013  945 EQFDRPVTVGYMYMLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDV 1024
                         1050      1060      1070
                   ....*....|....*....|....*....|....*...
gi 108796736  1005 TARAEAPNAIVTGNLVPKPiGTSDCLGVLIRELQCLGI 1042
Cdd:TIGR02013 1025 VGRTKAYEAIVKGENVPEP-GIPESFNVLIKELQSLGL 1061
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
13-1042 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 1000.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   13 LPDFKQIQIDSFRHFLTDLLRLELQRFGTIKHANQQLEFKLLGelYRLEIPKFNEREAVYQSATYSSNLYAPAYLVDKKR 92
Cdd:COG0085    13 LPNLLEIQLDSFNWFLEEGLQEIFDEISPIEDFTGNLSLEFGD--YRLGEPKYTPEECKERDLTYAAPLYVKVRLVNKET 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   93 GIIQKQTVFLGSIPLMSARGTFVIRGVSRCIVSQLLRSPGIYYT----LSVQGVYTATIICNSGKSFKLELDRQGCLWVR 168
Cdd:COG0085    91 GEIKEQEVFMGDFPLMTDSGTFIINGTERVIVSQLVRSPGVYFVeeedKSGKDLYSAKVIPSRGAWLEFETDKDGTIYVR 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  169 VGRNSKAPLL--------------LLLIALGLEMRYIPPMIVQRTKKLnqlllcVEDAKIDLCKRLKLKQKTTqIELGVT 234
Cdd:COG0085   171 IDRKRKIPVTvllralgletdeeiLEAFGDDPIQEYILATLEKDNTKT------QEEALLEIYRKLRPGEPPT-IERAEQ 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  235 DpIYSLFLKP--YELGRMGRLNLNKRLNLRVSEFEILLRSQDLIVASDYLVQVSNGIGSLDDIDDLKHKRVKWVSDLFCV 312
Cdd:COG0085   244 L-LDNLFFDPkrYDLAHVGRYKINKKLGLDVPPEDRVLTAEDIVATIKYLLELHLGEREPDDIDHLGNRRVRLVGELLQN 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  313 QLNMALKKLNVAVHTNLNKMEARisRMSLKSVVSSNAIATTFFRFVASYQLSQFLDQTNPLSEIVHKRKLSLLGPGGLTP 392
Cdd:COG0085   323 QFRVGLSRMERVVRERMTTQDVE--AITPQSLINIRPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLSR 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  393 RTARFRVRDIHPSQYGRICPVQTAEGQNAGVVNSFTICAHIGDNGAIKTSLYKVCTnsmqGHV---IDML-PGEDEYSTI 468
Cdd:COG0085   401 ERAGFEVRDVHPSHYGRMCPIETPEGPNIGLIGSLALYARVNEYGFIETPYRKVEN----GKVtdeIEYLtADEEENYYI 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  469 ATESCLVVANSSNQFQSIPAQHRREFVTLRWDEIGFRNTLPVHSFSVGVVLIPFLEHDDATRALMGSNMQRQAVPLLKLE 548
Cdd:COG0085   477 AQANAPLDEDGNFLEERVLVRYRGEEVLVPPEEVDYMDVSPKQIVSVATSLIPFLEHDDANRALMGANMQRQAVPLLRPE 556
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  549 RPivgtgiesqvaldsgtvitavqeckihnvdatqiayvpkdsfeLLYINLLNYERSNNATCLHQRPIVECGETVQKGQL 628
Cdd:COG0085   557 AP-------------------------------------------LLHYPLQKFQRSNQGTCINQRPIVRVGDRVEKGDV 593
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  629 IADGSATVDGELALGKNVLVAYMPWEGYNFEDAVLINERLIYEDVYTSLHIERYEAEARETNQAIETITKQIPHLNAHVL 708
Cdd:COG0085   594 LADGPATDNGELALGQNLLVAFMPWEGYNYEDAIIISERLVKDDVLTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEAL 673
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  709 RHLDETGVVSLGAWVETGDVLVGKLTAKqSEGLLhTPESKLLQDILGVQAFGTQDTCLKVPTRGEGRVIDVRWITRDN-- 786
Cdd:COG0085   674 RNLDEDGIIRIGAEVKGGDILVGKVTPK-GETEL-TPEERLLRAIFGEKAREVRDTSLRVPHGEKGKVIDVKVFSREEgd 751
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  787 -HLLGHRKVIHVYILQERKIQVGDKVAGRHGNKGVVSRILPRQDMPYLQDGTPVDMVLSPLGVPSRMNVGQVFECLLGLA 865
Cdd:COG0085   752 eLPPGVNKLVRVYVAQKRKIEVGDKLAGRHGNKGVISRILPQEDMPFLEDGTPVDIVLNPLGVPSRMNVGQVLETHLGWA 831
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  866 GGYLNQHYRIMPFDERYGREssrklVFSELYKAsqttnypwIFEPDspGKSRLFDGRTGEVFNQPVTVGRAYMFKLIHQV 945
Cdd:COG0085   832 AALLGRRVATPVFDGAPEEE-----IRELLEKA--------GLPPD--GKEVLYDGRTGEPFDNPVTVGYMYYLKLHHMV 896
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  946 DDKIHARSTGPYALVTQQPVRGRSRQGGQRVGEMEVWAFQGFGAACVLQELLTTKSDHATARAEAPNAIVTGNLVPKPiG 1025
Cdd:COG0085   897 DDKIHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQERLTIKSDDVCGRVKVYEAIVKGENIPEP-G 975
                        1050
                  ....*....|....*..
gi 108796736 1026 TSDCLGVLIRELQCLGI 1042
Cdd:COG0085   976 IPESFKVLLKELQSLGL 992
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
18-1042 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 763.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   18 QIQIDSFRHFLTDLLRLELQRFGTIKHANQQLEFKLLGELYRLEIPKFNE---------REAVYQSATYSSNLYAPAYLV 88
Cdd:cd00653     3 KQQIDSFNYFLNVGLQEIVKSIPPITDTDDDGRLKLKFGDIYLGKPKVEEggvtrkltpNECRLRDLTYSAPLYVDIRLT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   89 DKKRGIIQKQTVFLGSIPLM------------------------SARGTFVIRGVSRCIVSQLLRSPGIYYTLSVQG--V 142
Cdd:cd00653    83 VNDKGKIKEQEVFIGEIPIMlrsklcnlngltpeeliklgecplDPGGYFIINGTEKVIINQEQRSPNVIIVEDSKGkrI 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  143 YTATIICNSGKSFKLELDrqgclwvrvgrnskaplllllialglemryippmivqrtkklnqlllcvedakidlckrLKL 222
Cdd:cd00653   163 YTKTSIPSYSPYRGSWLE-----------------------------------------------------------VKS 183
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  223 KQKTTQIELgvtdpiyslflkpyelgrmgRLNLNKRLNLRvseFEILLRSQDLIVASDYLVQVSNGIGSLDDIDDLKHKR 302
Cdd:cd00653   184 DKKKDRIYV--------------------RIDLKRQEEAL---KYIGKRFEDLIYMIRKLILLVLGKGKLDDIDHLGNKR 240
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  303 VKWVSDLFCVQLNMALKKLNVAVHTNLNKMEARISRMSLKSVVSSNAIATTFFRFVASYQ------------LSQFLDQT 370
Cdd:cd00653   241 VRLAGELLQNLFRSGLKRLEREVKEKLQKQLSKKKDLTPQLLINSKPITSGIKEFLATGNwgskrflmqrsgLSQVLDRL 320
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  371 NPLSEIVHKRKLSllgPGGLTPRTARFRVRDIHPSQYGRICPVQTAEGQNAGVVNSFTICAHIgdNGAIKTSLYKVctns 450
Cdd:cd00653   321 NPLSELSHKRRIS---SLGLFRERKGFEVRDLHPSHWGRICPIETPEGENCGLVKNLALMARI--SGRIERPYRIV---- 391
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  451 mqghvidmlpgedeystiatesclvvanssnqfqsipaqhrREFVTLRwdEIGfrntlPVHSFSVGVVLIPFLEHDDATR 530
Cdd:cd00653   392 -----------------------------------------EKEVTHI--EIS-----PSQILSVAASLIPFPEHNQSPR 423
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  531 ALMGSNMQRQAVP----------------LLKLERPIVGTGIESQVALDsgtvitavqeckihnvdatqiayvpkdsfel 594
Cdd:cd00653   424 NLYQSNMQKQAVGtpalnqqyrmdtklylLLYPQKPLVGTGIEEYIAFG------------------------------- 472
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  595 lyinllnyersnnatclhqrpivecgetvqkgqliadgsatvdgELALGKNVLVAYMPWEGYNFEDAVLINERLIYEDVY 674
Cdd:cd00653   473 --------------------------------------------ELPLGQNAIVAVMSYSGYNFEDAIIINKSSVDRGFF 508
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  675 TSLHIERYEAEARETNQAIETITK-QIPHLNAHVLRHLDETGVVSLGAWVETGDVLVGKLTAKQSEGLLHtpeskllqdI 753
Cdd:cd00653   509 RSIHYKKYEIELRKTKNGPEEITRgDIPNVSEEKLKNLDEDGIIRPGARVEPGDILVGKITPKGETESTP---------I 579
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  754 LGVQAFGTQDTCLKVPTRGEGRVIDVRWITRDNhLLGHRKVIHVYILQERKIQVGDKVAGRHGNKGVVSRILPRQDMPYL 833
Cdd:cd00653   580 FGEKARDVRDTSLKYPGGEKGIVDDVKIFSREL-NDGGNKLVKVYIRQKRKPQIGDKFASRHGQKGVISKILPQEDMPFT 658
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  834 QDGTPVDMVLSPLGVPSRMNVGQVFECLLGLAGGYLNQHYRIMPFDERYGRESSRKLVFSELykasqttNYPwifepdsp 913
Cdd:cd00653   659 EDGIPPDIILNPHGFPSRMTIGQLLESLLGKAGALLGKFGDATPFDGAEEEDISELLGEAGL-------NYY-------- 723
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  914 GKSRLFDGRTGEVFNQPVTVGRAYMFKLIHQVDDKIHARSTGPYALVTQQPVRGRSRQGGQRVGEMEVWAFQGFGAACVL 993
Cdd:cd00653   724 GKEVLYDGRTGEPLEAPIFVGPVYYQRLKHMVDDKIHARSTGPYSLLTRQPLKGRSRGGGQRFGEMERDALIAHGAAYLL 803
                        1050      1060      1070      1080      1090
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 108796736  994 QELLTTKSDHATARAEAPNAIV-TGNLVPKPIGTSDC--------LGVLIRELQCLGI 1042
Cdd:cd00653   804 QERLTIKSDDVVARVCVKCGIIlSANLCRLCKKGTNIskvgipyaFKLLFQELQSMNI 861
PRK09603 PRK09603
DNA-directed RNA polymerase subunit beta/beta';
63-1045 0e+00

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 181983 [Multi-domain]  Cd Length: 2890  Bit Score: 677.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   63 PKFNEREAVYQSATYSSNLYAPAYLV----DKKRG------IIQKQTVFLGSIPLMSARGTFVIRGVSRCIVSQLLRSPG 132
Cdd:PRK09603   78 SKYTVREAMERGITYSIPLKIKVRLIlwekDTKSGekngikDIKEQSIFIREIPLMTERTSFIINGVERVVVNQLHRSPG 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  133 IYY------TLSVQGVYTATIICNSGKSFKLELDRQGCLWVRVGRNSKAPLLLL------------------LIALGLEM 188
Cdd:PRK09603  158 VIFkeeessTSLNKLIYTGQIIPDRGSWLYFEYDSKDVLYARINKRRKVPVTILframdyqkqdiikmfyplVKVRYEND 237
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  189 RYIPP--------------------MIVQRTKKLNQ---------------------------------------LLLCV 209
Cdd:PRK09603  238 KYLIPfasldanqrmefdlkdpqgkIILLAGKKLTSrkikelkenhlewveypmdillnrhlaepvmvgkevlldMLTQL 317
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  210 EDAKI---------------DLC---------------KRLKLKQKTTQIE-------------LGVTDPIYS------- 239
Cdd:PRK09603  318 DKNKLekihdlgvqefviinDLAlghdasiihsfsadsESLKLLKQTEKIDdenalaairihkvMKPGDPVTTevakqfv 397
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  240 --LFLKP--YELGRMGRLNLNKRLNLRVSEFEILLRSQDLIVASDYLVQVSNGIGSLDDIDDLKHKRVKWVSDLFCVQLN 315
Cdd:PRK09603  398 kkLFFDPerYDLTMVGRMKMNHKLGLHVPDYITTLTHEDIITTVKYLMKIKNNQGKIDDRDHLGNRRIRAVGELLANELH 477
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  316 MALKKLNVAVHTNLNKMEARISRMSLKSVVSSNAIATTFFRFVASYQLSQFLDQTNPLSEIVHKRKLSLLGPGGLTPRTA 395
Cdd:PRK09603  478 SGLVKMQKTIKDKLTTMSGAFDSLMPHDLVNSKMITSTIMEFFMGGQLSQFMDQTNPLSEVTHKRRLSALGEGGLVKDRV 557
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  396 RFRVRDIHPSQYGRICPVQTAEGQNAGVVNSFTICAHIGDNGAIKTSLYKVctnsMQGHVIDmlpgEDEYSTIATESCLV 475
Cdd:PRK09603  558 GFEARDVHPTHYGRICPIETPEGQNIGLINTLSTFTRVNDLGFIEAPYKKV----VDGKVVG----ETIYLTAIQEDSHI 629
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  476 VANSSNQFQS--------IPAQHRREFVTLRWDEIGFRNTLPVHSFSVGVVLIPFLEHDDATRALMGSNMQRQAVPLLKL 547
Cdd:PRK09603  630 IAPASTPIDEegnilgdlIETRVEGEIVLNEKSKVTLMDLSSSMLVGVAASLIPFLEHDDANRALMGTNMQRQAVPLLRS 709
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  548 ERPIVGTGIESQVALDSGTVITAVQECKIHNVDATQIaYVPKDSFELLYIN---LLNYERSNNATCLHQRPIVECGETVQ 624
Cdd:PRK09603  710 DAPIVGTGIEKIIARDSWGAIKANRAGVVEKIDSKNI-YILGEGKEEAYIDaysLQKNLRTNQNTSFNQVPIVKVGDKVE 788
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  625 KGQLIADGSATVDGELALGKNVLVAYMPWEGYNFEDAVLINERLIYEDVYTSLHIERYEAEARETNQAIETITKQIPHLN 704
Cdd:PRK09603  789 AGQIIADGPSMDRGELALGKNVRVAFMPWNGYNFEDAIVVSERITKDDIFTSTHIYEKEVDARELKHGVEEFTADIPDVK 868
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  705 AHVLRHLDETGVVSLGAWVETGDVLVGKLTAKQSegLLHTPESKLLQDILGVQAFGTQDTCLKVPTRGEGRVIDVRWITR 784
Cdd:PRK09603  869 EEALAHLDESGIVKVGTYVSAGMILVGKTSPKGE--IKSTPEERLLRAIFGDKAGHVVNKSLYCPPSLEGTVIDVKVFTK 946
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736      --------------------------------------------------------------------------------
Cdd:PRK09603  947 kgyekdarvlsayeeekakldmehfdrltmlnreellrvssllsqaileepfshngkdykegdqipkeeiasinrftlas 1026
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  785 ----------------DNHLLGHRKV-------------------------IHVYILQERKIQVGDKVAGRHGNKGVVSR 823
Cdd:PRK09603 1027 lvkkyskevqnhyeitKNNFLEQKKVlgeeheeklsilekddilpngvikkVKLYIATKRKLKVGDKMAGRHGNKGIVSN 1106
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  824 ILPRQDMPYLQDGTPVDMVLSPLGVPSRMNVGQVFECLLGLAGGYLNQHYRIMPFDER---------------------- 881
Cdd:PRK09603 1107 IVPVADMPYTADGEPVDIVLNPLGVPSRMNIGQILEMHLGLVGKEFGKQIASMLEDKTkdfakelrakmleianainekd 1186
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  882 -----------------YGRESSRKLVFS-ELYKASQTTNYPWIFE---PDSPGKSRLFDGRTGEVFNQPVTVGRAYMFK 940
Cdd:PRK09603 1187 pltihalencsdeelleYAKDWSKGVKMAiPVFEGISQEKFYKLFElakIAMDGKMDLYDGRTGEKMRERVNVGYMYMIK 1266
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  941 LIHQVDDKIHARSTGPYALVTQQPVRGRSRQGGQRVGEMEVWAFQGFGAACVLQELLTTKSDHATARAEAPNAIVTGnlv 1020
Cdd:PRK09603 1267 LHHLVDEKVHARSTGPYSLVTHQPVGGKALFGGQRFGEMEVWALEAYGAAHTLKEMLTIKSDDIRGRENAYRAIAKG--- 1343
                        1290      1300
                  ....*....|....*....|....*...
gi 108796736 1021 pKPIGTS---DCLGVLIRELQCLGIQLD 1045
Cdd:PRK09603 1344 -EQVGESeipETFYVLTKELQSLALDIN 1370
PRK14844 PRK14844
DNA-directed RNA polymerase subunit beta/beta';
28-1055 0e+00

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 173305 [Multi-domain]  Cd Length: 2836  Bit Score: 615.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   28 LTDLLRLELQRFGTI---KHANQQLE------FKLLGELYRLEI---------PKFNEREAVYQSATYSSNLYAPAYLVD 89
Cdd:PRK14844   29 LLDLVKVQKESYDSFtpkNKGNERLEvifhtiFPINDPLHRATIefiscrvddPKYDESECIKRGITFSAQVIASIRLVI 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   90 KKRGI-----------------------IQKQTVFLGSIPLMSARGTFVIRGVSRCIVSQLLRSPGIYYTlSVQG----- 141
Cdd:PRK14844  109 MQDGIsldeyksikesgdhsklatviksIEEQEVHFCELPMMTDKGTFIINGVEKVIVSQMHRSPGVFFD-SDKGktyns 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  142 ---VYTATIICNSGKSFKLELDRQGCLWVRVGRNSKAPLLLLLIAL-----------GLEMRYIP-------PMI----- 195
Cdd:PRK14844  188 gklIYSARVIPYRGSWLDIEFDVKDHLYFRIDRKRKLPISVLLKALglsnndildrfYEKIKYIKhkdgwkvPFVpdkfk 267
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  196 --------------------VQRTKKL----------------------------------NQLLLCVEDAKIDLCKRLK 221
Cdd:PRK14844  268 gvrlpfdlmdvegnvllkanVRITSRLakklydnelkeylvpfdsicglflaedlidsassTKILSAGESIKLEDIKKLE 347
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  222 L----KQKTTQIE-----------------LGVTDPIYSLF--LKP----------------------YELGRMGRLNLN 256
Cdd:PRK14844  348 LlsidEISVLNIDnlsvgpyilntlfldenMSYQDALYEIYkvLRPgevpvleiveeffrnlffspeyYDLSNIGRLKLN 427
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  257 KRLNLRVSEFEILLRSQDLIVASDYLVQVSNGIGSLDDIDDLKHKRVKWVSDLFCVQLNMALKKLNVAVHTNLNKmeARI 336
Cdd:PRK14844  428 SYLGLNYDEDLTVLTHEDIIEIVRKIVLLRDGQGSVDDIDHLGNRRVRSVGEFIENQFRTGLLKLERAVVDSMST--SSL 505
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  337 SRMSLKSVVSSNAIATTFFRFVASYQLSQFLDQTNPLSEIVHKRKLSLLGPGGLTPRTARFRVRDIHPSQYGRICPVQTA 416
Cdd:PRK14844  506 DKVSPSDFINPKVLTNVLRDFFNSSQLSQFMDQTNPLSEITHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETP 585
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  417 EGQNAGVVNSFTICAHIGDNGAIKtSLYKVCTNSMQGHVIDMLPGEDEYST-IATESCLVVANSSNQFQSIPAQHRREFV 495
Cdd:PRK14844  586 EGQNIGLINSLAIYARINKYGFIE-SPYRKVVNRVVTDQIEYLSAIDEGLYyIADTSAKLDENNCFVDDMLYCRYAGSFV 664
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  496 TLRWDEIGFRNTLPVHSFSVGVVLIPFLEHDDATRALMGSNMQRQAVPLLKLERPIVGTGIESQVALDSGTVITAVQECK 575
Cdd:PRK14844  665 MVSSDQVSYIDVSPKQVISVAASLIPFLENDDANRALMGSNMQRQAVPLLKPTAPLVATGMESFVASGSGAVVLAKRDGI 744
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  576 IHNVDATQIAYVPKDSFELLYIN-----LLNYERSNNATCLHQRPIVECGETVQKGQLIADGSATVDGELALGKNVLVAY 650
Cdd:PRK14844  745 VDSSDSNSIVIRAFDKERVNYLDvdiyhLRKFQRSNHNTCINQKPLVCVGDYVKEGDVIADGPAINSGELALGQNLLVAF 824
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  651 MPWEGYNFEDAVLINERLIYEDVYTSLHIERYEAEARETNQAIETITKQIPHLNAHVLRHLDETGVVSLGAWVETGDVLV 730
Cdd:PRK14844  825 MSWQGYNFEDSIIISSEVVKKDLFTSIHIEEFECVVHDTPLGSEKITRAIPGVNEENLYHLDDSGIVKIGTRVGPGYILV 904
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  731 GKLTAKQSegLLHTPESKLLQDILGVQAFGTQDTCLKVPTRGEGRVIDVRWITR-----------------------DNH 787
Cdd:PRK14844  905 GKVTPKPS--LSLPPETKLLMTIFGEKSFDCADSSLYTSPDVEGTVIDVQVFTRrgveenerallikqkeindfekeRDY 982
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  788 LLG-----------------------------------------------------------------HRKV-------- 794
Cdd:PRK14844  983 IINvtseyfydelkkllinsgsqdrekfdsiereqwwgiglknqsiseqvkslkkdfdekvshaiaqfKRKVeklhegyd 1062
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  795 --------IHVYILQERKIQVGDKVAGRHGNKGVVSRILPRQDMPYLQDGTPVDMVLSPLGVPSRMNVGQVFECLLGLA- 865
Cdd:PRK14844 1063 lpqgvsmsVKVFIAVKHSLQPGDKMAGRHGNKGVISRVVPVEDMPYLEDGTPVDIILNPLGVPSRMNVGQILETHVGWAc 1142
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  866 -------GGYLNQ---------------------HYRIMPFDER------------------------------------ 881
Cdd:PRK14844 1143 kklgekvGNILDEinkiksafckgirslnddnftKFAAAYLDNKkienidddeitasvlntpnknalndelnelvenyln 1222
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  882 ------------------YGR-----------------ESSRKL-----VFSELYKASQTTNYPWIFE---PDSPGKSRL 918
Cdd:PRK14844 1223 scksaysnlrnflievysCGSnvsicnnirdisdnnliEFARKLrdgipVAAPVFEGPKDEQIAKLFElagLDNSGQAVL 1302
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  919 FDGRTGEVFNQPVTVGRAYMFKLIHQVDDKIHARSTGPYALVTQQPVRGRSRQGGQRVGEMEVWAFQGFGAACVLQELLT 998
Cdd:PRK14844 1303 YDGCSGEKFDRKVTVGYMYMLKLHHLVDGKIHARSVGPYSLVTQQPLGGKSHFGGQRFGEMECWALQAYGAAYTLQEMLT 1382
                        1370      1380      1390      1400      1410
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 108796736  999 TKSDHATARAEAPNAIVTGNlVPKPIGTSDCLGVLIRELQCLGIQLDhtmLSQHNMI 1055
Cdd:PRK14844 1383 VKSDDINGRVKIYESIIKGD-SNFECGIPESFNVMIKELRSLCLNVD---LKQNDVV 1435
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
519-970 1.40e-134

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 411.15  E-value: 1.40e-134
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   519 LIPFLEHDDATRALMGSNMQRQAVpllklerpivgtGIesqvaldsgtvitavqeckihnvdatqiayvpkdsfellyIN 598
Cdd:pfam00562    4 LIPFVDHNQSPRNTYQCAMGKQAM------------GI----------------------------------------YT 31
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   599 LLNYERSNNAT---CLHQRPIVECGeTVQKGQLiadgsatvdGELALGKNVLVAYMPWEGYNFEDAVLINERLIYEDVYT 675
Cdd:pfam00562   32 LNKFYRSDQNTyvlCYPQKPLVKTG-AVEAGGF---------GELPLGQNAIVAVMSYTGYNQEDAIIINKSSVDRGFFT 101
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   676 SLHIERYEAEaRETNQAIETITKQIPHLNAHVLRHLDETGVVSLGAWVETGDVLVGKLTAkqsegllhTPESKLLQDILG 755
Cdd:pfam00562  102 SIHIKEIEAR-KTKLGPIEEITRDIPNVSEEALKKLDEDGIVRVGAEVKPGDILVGKVGP--------TELTKLLRAIFG 172
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   756 VQAFGTQDTCLKVPTRGEGRVIDVRWITRDNHllGHRKVIhVYILQERKIQVGDKVAGRHGNKGVVSRILPRQDMPYLQD 835
Cdd:pfam00562  173 EKARDVKDTSLKVPPGEEGVVDDVIVFELPPG--GIKMVK-VYIRQKRKPEVGDKFASRHGQKGVVSRILPQEDMPFTED 249
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   836 GTPVDMVLSPLGVPSRMNVGQVFECLLGLAGGYLNQHYRIMPFDeryGRESSRKLVFSELYKASqttnypwiFEPDspGK 915
Cdd:pfam00562  250 GIPPDIILNPHGVPSRMTIGQLLETHLGKAAALLGVFVDATPFD---GASTEVEDIGELLEKAG--------YNYY--GK 316
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 108796736   916 SRLFDGRTGEVFNQPVTVGRAYMFKLIHQVDDKIHARSTGPYALVTQQPVRGRSR 970
Cdd:pfam00562  317 EVLYDGRTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGPYSLLTRQPLGGRAR 371
PRK08565 PRK08565
DNA-directed RNA polymerase subunit B; Provisional
20-1042 2.69e-76

DNA-directed RNA polymerase subunit B; Provisional


Pssm-ID: 236291 [Multi-domain]  Cd Length: 1103  Bit Score: 272.99  E-value: 2.69e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   20 QIDSFRHFLTDLLRLELQRFGTIKHANQQLEFKLlgELYRLEIPKFNE----------REAVYQSATYSSNLYAPAYLVD 89
Cdd:PRK08565   18 HLDSYNDFIERGLQEIVDEFGEIKTEIPGLKIVL--GKIRVGEPEIKEadgserpitpMEARLRNLTYAAPLYLTMIPVE 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   90 KkrGIIQK-QTVFLGSIPLM--SAR----------------------GTFVIRGVSRCIVSQL-LRSPGIYYTLSVQG-- 141
Cdd:PRK08565   96 N--GIEYEpEEVKIGDLPIMvkSKIcplsglspdelieigedpkdpgGYFIINGSERVIVSQEdLAPNRVLVDKGEAGss 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  142 -VYTATIICNS-GKSFKLELDRQ--GCLWVRVGR-NSKAPLLLLlialgleMRY------------------IPPMIVQR 198
Cdd:PRK08565  174 iTHTAKVISSRaGYRAQVTVERRkdGTIYVSFPAvPGKIPFVIL-------MRAlgletdrdivyavsldpeIQQELLPS 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  199 TKKLNQLLLCVEDAKIDLCKRLKLKQ-KTTQIE-------------LGVT--DPIYslflKPYELGRMGRlnlnkrlnlr 262
Cdd:PRK08565  247 LEQASSIAATVEDALDYIGKRVAIGQpREYRIEraeqildkyllphLGTSpeDRIK----KAYFLGQMAS---------- 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  263 vsefeillrsqdlivasdYLVQVSNGIGSLDDIDDLKHKRVKWVSDLFCVQLNMALKKLNVAVHTNLNKMEARISRMSLK 342
Cdd:PRK08565  313 ------------------KLLELYLGRREPDDKDHYANKRLRLAGDLLAELFRVAFKQLVKDLKYQLEKSYARGRKLDLR 374
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  343 SVVSSNAIATTFFRFVASYQ-------LSQFLDQTNPLSEIVH-KRKLSLLgpggltPRT-ARFRVRDIHPSQYGRICPV 413
Cdd:PRK08565  375 AIVRPDIITERIRHALATGNwvggrtgVSQLLDRTNYLSTLSHlRRVVSPL------SRGqPHFEARDLHGTQWGRICPF 448
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  414 QTAEGQNAGVVNSFTICAHIG---DNGAIKTSLYKvctnsmqghvIDMLPGEDEYSTIATESCLVVANSSnqfqsIPAQH 490
Cdd:PRK08565  449 ETPEGPNCGLVKNLALMAQISvgvDEEEVEEILYE----------LGVVPVEEAREEEYISWSRVYLNGR-----LIGYH 513
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  491 R--REFV-TLRwdeiGFRNTLPVHSfsvgVVLIPFLEHDDATRALMGSNMQRQAVPLL-------KLERPIV-----GT- 554
Cdd:PRK08565  514 PdgEELAeKIR----ELRRSGKISD----EVNVAYIETGEINEVYVNCDSGRVRRPLIvvengkpKLTREHVeklkkGEl 585
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  555 --------GI----------ESQVALDSGTVITAVQECK-----IHNVDATQIAYV-----PKDSFEL------LYINLL 600
Cdd:PRK08565  586 tfddlvkmGVieyldaeeeeNAYVALDPEDLTPEHTHLEiwppaILGITASIIPYPehnqsPRNTYQAamakqsLGLYAA 665
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  601 NYERS--NNATCLH--QRPIVEcgetvqkgqliadgSATVD----GELALGKNVLVAYMPWEGYNFEDAVLINERLIYED 672
Cdd:PRK08565  666 NFRIRtdTRGHLLHypQRPLVQ--------------TRALEiigyNDRPAGQNAVVAVLSYTGYNIEDAIIMNKASIERG 731
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  673 VYTSLHIERYEAEARE----TNQAIETITKQIP-HLNAHVLRHLDETGVVSLGAWVETGDVLVGKltakqsegllhTPES 747
Cdd:PRK08565  732 LARSTFFRTYETEERKypggQEDKIEIPEPNVRgYRGEEYYRKLDEDGIVSPEVEVKGGDVLIGK-----------TSPP 800
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  748 KLLQDI--LGVQAFGTQDTclKVPTR-GEGRVIDVRWITRDNhllGHRKVIHVYILQERKIQVGDKVAGRHGNKGVVSRI 824
Cdd:PRK08565  801 RFLEELeeLSLGLQERRDT--SVTVRhGEKGIVDTVLITESP---EGNKLVKVRVRDLRIPELGDKFASRHGQKGVIGML 875
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  825 LPRQDMPYLQDGTPVDMVLSPLGVPSRMNVGQVFECLLGLAGGYLNQHYRIMPFDERyGRESSRKlvfsELYKASqttny 904
Cdd:PRK08565  876 VPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLESIAGKVAALEGRFVDATPFYGE-PEEELRK----ELLKLG----- 945
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  905 pwiFEPDspGKSRLFDGRTGEVFNQPVTVGRAYMFKLIHQVDDKIHARSTGPYALVTQQPVRGRSRQGGQRVGEMEVWAF 984
Cdd:PRK08565  946 ---YKPD--GTEVMYDGRTGEKIKAPIFIGVVYYQKLHHMVADKIHARARGPVQILTRQPTEGRAREGGLRFGEMERDCL 1020
                        1130      1140      1150      1160      1170      1180      1190
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 108796736  985 QGFGAACVLQELLTTKSDHAT--------------ARAEAPNAIV---TGNLvpKPIGTSDCLGVLIRELQCLGI 1042
Cdd:PRK08565 1021 IGHGAAMLLKERLLDSSDKTTiyvcelcghiawydRRKNKYVCPIhgdKGNI--SPVEVSYAFKLLLQELMSMGI 1093
rpoB_arch TIGR03670
DNA-directed RNA polymerase subunit B; This model represents the archaeal version of ...
513-1042 2.94e-65

DNA-directed RNA polymerase subunit B; This model represents the archaeal version of DNA-directed RNA polymerase subunit B (rpoB) and is observed in all archaeal genomes.


Pssm-ID: 274713 [Multi-domain]  Cd Length: 599  Bit Score: 231.84  E-value: 2.94e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   513 FSVGVVLIPFLEHDDATRALMGSNMQRQAVPLLKLERPIvgtgiesqvALDSgtvitavqecKIHnvdatqiayvpkdsf 592
Cdd:TIGR03670  127 LGIIASTIPYPEHNQSPRNTMGAAMAKQSLGLYAANYRI---------RLDT----------RGH--------------- 172
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   593 ellyinLLNYErsnnatclhQRPIVECGETVQKGQliadgsatvdGELALGKNVLVAYMPWEGYNFEDAVLINERLIYED 672
Cdd:TIGR03670  173 ------LLHYP---------QKPLVKTRVLELIGY----------DDRPAGQNFVVAVMSYEGYNIEDALIMNKASIERG 227
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   673 VYTSLHIERYEAEARE----TNQAIETITKQIP-HLNAHVLRHLDETGVVSLGAWVETGDVLVGKltakqsegllhTPES 747
Cdd:TIGR03670  228 LARSTFFRTYEAEERRypggQEDRFEIPEPDVRgYRGEEAYKHLDEDGIVYPEVEVKGGDVLIGK-----------TSPP 296
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   748 KLLQ--DILGVQAFGTQDTclKVPTR-GEGRVIDVRWITRDNHllGHRKViHVYILQERKIQVGDKVAGRHGNKGVVSRI 824
Cdd:TIGR03670  297 RFLEelREFGLVTERRRDT--SVTVRhGEKGIVDKVIITETEE--GNKLV-KVRVRDLRIPELGDKFASRHGQKGVIGMI 371
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   825 LPRQDMPYLQDGTPVDMVLSPLGVPSRMNVGQVFECLLGLAGGYLNQHYRIMPFDERyGRESSRKlvfsELYKASqttny 904
Cdd:TIGR03670  372 VPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLEMIAGKVAALEGRRVDGTPFEGE-PEEELRK----ELLKLG----- 441
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   905 pwiFEPDspGKSRLFDGRTGEVFNQPVTVGRAYMFKLIHQVDDKIHARSTGPYALVTQQPVRGRSRQGGQRVGEMEVWAF 984
Cdd:TIGR03670  442 ---FKPD--GKEVMYDGITGEKLEAEIFIGVIYYQKLHHMVADKIHARSRGPVQVLTRQPTEGRAREGGLRFGEMERDVL 516
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 108796736   985 QGFGAACVLQELLTTKSDHATA-----------------RAEAPNAIVTGNLvpKPIGTSDCLGVLIRELQCLGI 1042
Cdd:TIGR03670  517 IGHGAAMLLKERLLDESDKYVVyvcencghiawedkrkgTAYCPVCGETGDI--SPVEMSYAFKLLLDELKSLGI 589
PRK07225 PRK07225
DNA-directed RNA polymerase subunit B'; Validated
513-1002 6.68e-61

DNA-directed RNA polymerase subunit B'; Validated


Pssm-ID: 235972 [Multi-domain]  Cd Length: 605  Bit Score: 219.45  E-value: 6.68e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  513 FSVGVVLIPFLEHDDATRALMGSNMQRQAVPL----LKLeRPivgtgiesqvaldsgtvitavqECKIHnvdatqiayvp 588
Cdd:PRK07225  133 LGIGAGMIPYPEHNASPRITMGAGMIKQSLGLpaanYKL-RP----------------------DTRGH----------- 178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  589 kdsfellyinLLNYErsnnatclhQRPIVECGETVQKGqliadgsatVDGELAlGKNVLVAYMPWEGYNFEDAVLINERL 668
Cdd:PRK07225  179 ----------LLHYP---------QVPLVKTQTQEIIG---------FDERPA-GQNFVVAVMSYEGYNIEDALIMNKAS 229
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  669 IYEDVYTSLHIERYEAEARE----TNQAIEtitkqIPHLN------AHVLRHLDETGVVSLGAWVETGDVLVGKltakqs 738
Cdd:PRK07225  230 IERGLGRSHFFRTYEGEERRypggQEDRFE-----IPDKDvrgyrgEEAYRHLDEDGLVNPETEVKEGDVLIGK------ 298
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  739 egllhTPESKLL--QDILGVQAFGTQDTclKVPTR-GEGRVIDVRWITRDNHllGHRKViHVYILQERKIQVGDKVAGRH 815
Cdd:PRK07225  299 -----TSPPRFLeePDDFGISPEKRRET--SVTMRsGEEGIVDTVILTETEE--GSRLV-KVRVRDLRIPELGDKFASRH 368
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  816 GNKGVVSRILPRQDMPYLQDGTPVDMVLSPLGVPSRMNVGQVFECLLGLAGGyLNQHyRI--MPF---DERYGRESSRKL 890
Cdd:PRK07225  369 GQKGVIGLIVPQEDMPFTESGVVPDLIINPHAIPSRMTVGHVLEMIGGKVGS-LEGR-RVdgTAFsgeDEEDLREALEKL 446
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736  891 VFSelykasqttnypwifepdSPGKSRLFDGRTGEVFNQPVTVGRAYMFKLIHQVDDKIHARSTGPYALVTQQPVRGRSR 970
Cdd:PRK07225  447 GFE------------------HTGKEVMYDGITGEKIEAEIFVGVIYYQKLHHMVANKLHARSRGPVQVLTRQPTEGRAR 508
                         490       500       510
                  ....*....|....*....|....*....|..
gi 108796736  971 QGGQRVGEMEVWAFQGFGAACVLQELLTTKSD 1002
Cdd:PRK07225  509 EGGLRFGEMERDVLIGHGAAMLLKERLLDESD 540
RNA_pol_Rpb2_3 pfam04565
RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of ...
365-432 2.15e-27

RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 3, s also known as the fork domain and is proximal to catalytic site.


Pssm-ID: 428011 [Multi-domain]  Cd Length: 67  Bit Score: 105.69  E-value: 2.15e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 108796736   365 QFLDQTNPLSEIVHKRKLSLlGPGGLTPRTARFRVRDIHPSQYGRICPVQTAEGQNAGVVNSFTICAH 432
Cdd:pfam04565    1 QVLDRTNYLSTLSHLRRVNS-PRGGLFREMKTTEVRDLHPSHWGRICPVETPEGPNCGLVKHLALYAR 67
RNA_pol_Rpb2_7 pfam04560
RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of ...
972-1042 1.64e-15

RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain comprised of the structural domains anchor and clamp. The clamp region (C-terminal) contains a zinc-binding motif. The clamp region is named due to its interaction with the clamp domain found in Rpb1. The domain also contains a region termed "switch 4". The switches within the polymerase are thought to signal different stages of transcription.


Pssm-ID: 461355 [Multi-domain]  Cd Length: 87  Bit Score: 72.62  E-value: 1.64e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   972 GGQRVGEMEVWAFQGFGAACVLQELLTTKSD----HATARAEAPNA-----IVTGNLVPKPIGTSDCLGVLIRELQCLGI 1042
Cdd:pfam04560    1 GGLRFGEMERWALIAYGAAHTLQERLTIKSDayevDVCGRCGLYAAynkcpICKGETDISPGYIPESFKLLFQELQSLGI 80
RNA_pol_Rpb2_2 pfam04561
RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of ...
129-304 5.85e-15

RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the lobe domain. DNA has been demonstrated to bind to the concave surface of the lobe domain, and plays a role in maintaining the transcription bubble. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 1 (DRI).


Pssm-ID: 398318 [Multi-domain]  Cd Length: 185  Bit Score: 74.31  E-value: 5.85e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   129 RSPGIYYTL-----SVQGVYTATIICNSGKSFKLELDRQGCLWVRVGRNSKaplllllialglemryIPPMIVQR----- 198
Cdd:pfam04561    1 RSNGIYVEKeldknGIIATYTSSLISNRGSWLKLEIDGKTLIWSRPSKKRK----------------IPIVIFLKalglv 64
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   199 TKK--LNQLLLCVEDAKIDLCKRLKLKQK----TTQIELgvtDPIYSLFL----KPYELG--------RMGRLNLNKRLN 260
Cdd:pfam04561   65 SDReiLDRLCYDFNDPQMLELLKPELEEAeniyTQEEAL---DYIGKGFAlrrgEEPRLQrareilysRDPKYNLNKHLG 141
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 108796736   261 LRVSEFEILLRSQDLIVASDYLVQVSNGIGSLDDIDDLKHKRVK 304
Cdd:pfam04561  142 LNEPFENERLKAQDILYMIDRLLNLKLGRRKPDDIDHLGNKRVR 185
RNA_pol_Rpb2_1 pfam04563
RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. ...
18-350 8.53e-11

RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the protrusion domain. The other lobe (pfam04561) is nested within this domain.


Pssm-ID: 367994 [Multi-domain]  Cd Length: 396  Bit Score: 65.09  E-value: 8.53e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736    18 QIQIDSFRHFLTDLLRLELQRFGTI------KHANQQLE-FKLLGELYRLEIPKFNER----------EAVYQSATYSSN 80
Cdd:pfam04563    4 RQQLDSFNEFVDNDLQKIIDENALIesefeiQHPGENGDkLSLKFGQIRLGKPMFDETdgstreiypqECRLRNLTYSAP 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736    81 LYAPAYLVDKKRGIIQKQTVFLGSIPLM--SAR----------------------GTFVIRGVSRCIVSQLLRS---PGI 133
Cdd:pfam04563   84 LYVDLELSVYNGEDIKPIEVFIGRLPIMlrSNAcilsgateselvklgecpldpgGYFIINGSEKVIVAQEHRSrnhPIV 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   134 YY------TLSVQGVYTATIICNSGKSfkleldrqgCLWVRVGRNSKAPLLLLLIALGLemRYIPPMIVQR-------TK 200
Cdd:pfam04563  164 FKkadpkkRGSVASVRSSAEISVRPDS---------TSWVNVLEYLSNGTIYFKFPYIK--KEIPIVIILRalgftsdRE 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   201 KLNQLLLCVEDAKIDLCKRLKLKQ---KTTQIELGVTDPIYSLFLKPYELG--RMGRLN-----LNKRL--NLRVSEFEI 268
Cdd:pfam04563  233 IFELICYDVNDQQLQEELLPSLEEgfkIRIQTQEQALDYIGGRGRAIFRMGrpREPRIKyaeeiLQKEVlpHLGTYELDE 312
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108796736   269 LLRSQDLIVASDYLVQVSNGIGSLDDIDDLKHKRVKWVSDLFCVQLNMALKKLNVAVHTNLNKMEARISRMSLKSVVSSN 348
Cdd:pfam04563  313 TKKAYFIGYMIRRLLLLALGRREVDDRDHLGNKRLRLAGPLLASLFRVLFKKLVRDVRERLQKVLGSPDDLMLQLLVNAK 392

                   ..
gi 108796736   349 AI 350
Cdd:pfam04563  393 PI 394
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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