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Conserved domains on  [gi|2252659249|ref|YP_010409968|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Alouatta discolor]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 4.99e-38

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 122.73  E-value: 4.99e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252659249  1 MPFIYINTSLAYFMSLLGLLIYRSHLMSSLLCLEGMMLSLFIMVTLTTLNMHLMLTYMMPITLLVFAACEAAVGLALLVL 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 2252659249 81 ISNLYGLDYVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 4.99e-38

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 122.73  E-value: 4.99e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252659249  1 MPFIYINTSLAYFMSLLGLLIYRSHLMSSLLCLEGMMLSLFIMVTLTTLNMHLMLTYMMPITLLVFAACEAAVGLALLVL 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 2252659249 81 ISNLYGLDYVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
4-98 5.10e-13

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 59.11  E-value: 5.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252659249  4 IYINTSLAYFMSLLGLLIYRSHLMSSLLCLEGMMLSLFIMVTLTTLNMHLMLTYMMPITLLVFAACEAAVGLALLVLISN 83
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLLLRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYR 80

                         90
                 ....*....|....*
gi 2252659249 84 LYGLDYVQNLNLLQC 98
Cdd:pfam00420 81 THGTDDVDSLNLLKG 95
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 4.99e-38

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 122.73  E-value: 4.99e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252659249  1 MPFIYINTSLAYFMSLLGLLIYRSHLMSSLLCLEGMMLSLFIMVTLTTLNMHLMLTYMMPITLLVFAACEAAVGLALLVL 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 2252659249 81 ISNLYGLDYVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.91e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 85.79  E-value: 1.91e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252659249  1 MPFIYINTSLAYFMSLLGLLIYRSHLMSSLLCLEGMMLSLFIMVTLTTLNMHLMLTYMMPITLLVFAACEAAVGLALLVL 80
Cdd:MTH00126   1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                         90
                 ....*....|....*...
gi 2252659249 81 ISNLYGLDYVQNLNLLQC 98
Cdd:MTH00126  81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 4.99e-22

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 82.20  E-value: 4.99e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252659249  1 MPFIYINTSLAYFMSLLGLLIYRSHLMSSLLCLEGMMLSLFIMVTLTTLNMHLMLTYMMPITLLVFAACEAAVGLALLVL 80
Cdd:MTH00125   1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                         90
                 ....*....|....*...
gi 2252659249 81 ISNLYGLDYVQNLNLLQC 98
Cdd:MTH00125  81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 5.71e-18

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 71.94  E-value: 5.71e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252659249  1 MPFIYINTSLAYFMSLLGLLIYRSHLMSSLLCLEGMMLSLFIMVTLTTLNMHLMLTYMMPITLLVFAACEAAVGLALLVL 80
Cdd:MTH00067   1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                         90
                 ....*....|....*...
gi 2252659249 81 ISNLYGLDYVQNLNLLQC 98
Cdd:MTH00067  81 TTRTHGTDHLKNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
4-98 5.10e-13

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 59.11  E-value: 5.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252659249  4 IYINTSLAYFMSLLGLLIYRSHLMSSLLCLEGMMLSLFIMVTLTTLNMHLMLTYMMPITLLVFAACEAAVGLALLVLISN 83
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLLLRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYR 80

                         90
                 ....*....|....*
gi 2252659249 84 LYGLDYVQNLNLLQC 98
Cdd:pfam00420 81 THGTDDVDSLNLLKG 95
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 4-96 6.61e-13

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 58.80  E-value: 6.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252659249  4 IYINTSLAYFMSLLGLLIYRSHLMSSLLCLEGMMLSLFIMVTLTTLNMHLMLTYMMPITLLVFAACEAAVGLALLVLISN 83
Cdd:MTH00181   1 MMFVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNR 80

                         90
                 ....*....|...
gi 2252659249 84 LYGLDYVQNLNLL 96
Cdd:MTH00181  81 THGSDHLLKFNLL 93
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 1.82e-09

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 49.92  E-value: 1.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252659249  1 MPFIYINTSLAYFMSLLGLLIYRSHLMSSLLCLEGMMLSLFIMVTLTTLNMHLMLTYMMPITLLVFAACEAAVGLALLVL 80
Cdd:MTH00043   1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                         90
                 ....*....|....*..
gi 2252659249 81 ISNLYGLDYVQNLNLLQ 97
Cdd:MTH00043  81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 13-98 7.30e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 46.12  E-value: 7.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252659249 13 FMSLLGLLIYRSHLMSSLLCLEGMMLSLFIMVTLTTLNMhlMLTYMMPITLLVFAACEAAVGLALLVLISNLYGLDYVQN 92
Cdd:MTH00188  14 VLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYM--EKELYLSLVLLTFAACEASVGLALLVSLIRSHGSDYVSS 91


                 ....*.
gi 2252659249 93 LNLLQC 98
Cdd:MTH00188  92 LNLIKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 9-98 8.24e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 45.61  E-value: 8.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252659249  9 SLAYFMSLLGLLIYRSHLMSSLLCLEGMMLSLFIMvtLTTLNMHLMLTYMMPITLLVFAACEAAVGLALLVLISNLYGLD 88
Cdd:MTH00149  10 LFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVM--MFSSSGLISFSSYLFLIILTFGACEASLGLSLLVSLIRLHGND 87

                         90
                 ....*....|
gi 2252659249 89 YVQNLNLLQC 98
Cdd:MTH00149  88 YVSSLSSLKF 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 12-92 3.98e-06

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 41.29  E-value: 3.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252659249 12 YFMSLLGLLIYRSHLMSSLLCLEGMMLSLFIMVTLTTlnMHLMLTYMMPITLLVFAACEAAVGLALLVLISNLYGLDYVQ 91
Cdd:MTH00162  11 FFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYL--SFFNYELYFLLFFLTFSVCEGALGLSILVSMIRSHGNDYFS 88


                 .
gi 2252659249 92 N 92
Cdd:MTH00162  89 S 89
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 9-98 6.62e-06

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 40.89  E-value: 6.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2252659249  9 SLAYFMSLLGLLIYRSHLMSSLLCLEGMMLSLFIMVTLTTLNMHLMLTYMMpITLLVFAACEAAVGLALLVLISNLYGLD 88
Cdd:MTH00013   9 SISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFANQVNGMLA-IVLLTFGACEASLGLSLLVLMTRSYGND 87

                         90
                 ....*....|
gi 2252659249 89 YVQNLNLLQC 98
Cdd:MTH00013  88 MLKSLTSNKC 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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