NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|378978478|ref|YP_005226619|]
View 

hypothetical protein KPHS_23190 [Klebsiella pneumoniae subsp. pneumoniae HS11286]

Protein Classification

type VI secretion lipoprotein TssJ( domain architecture ID 10007514)

type VI secretion lipoprotein TssJ is an outer membrane-associated component that forms the core complex with TssL and TssM inner-membrane proteins

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG3521 COG3521
Predicted component of the type VI protein secretion system [Intracellular trafficking, ...
 21-180 2.21e-51

Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport];


:

Pssm-ID: 442743  Cd Length: 168  Bit Score: 162.45  E-value: 2.21e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378978478  21 SGCGLTQRVSegtksafnAVFYKKINTLHLDFTAREALNTDARENhslSEPVVVRIYQLKDRQTFDRLVYQQLLEEGDIL 100
Cdd:COG3521   22 AGCGSTQKVT--------VIFYKQPTTLHLTLTAAPDLNPDANGR---PSPVVVRVYQLKDDSAFESADFFALLDDDEEA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378978478 101 LAADLLASRDVVIGPGGDASLNMPLEAEATFVAVVGLFRHPDtqRNTWKQVLAREELDPDKPRIFTAEHNQLRLRPEAAK 180
Cdd:COG3521   91 LGADLLSVKELTLLPGESKTLDLPLDPEARYIGVVALFRDPD--GARWRLVIPVPELDSDGKLTIELGGNAITLVPEKEV 168
 
Name Accession Description Interval E-value
COG3521 COG3521
Predicted component of the type VI protein secretion system [Intracellular trafficking, ...
 21-180 2.21e-51

Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442743  Cd Length: 168  Bit Score: 162.45  E-value: 2.21e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378978478  21 SGCGLTQRVSegtksafnAVFYKKINTLHLDFTAREALNTDARENhslSEPVVVRIYQLKDRQTFDRLVYQQLLEEGDIL 100
Cdd:COG3521   22 AGCGSTQKVT--------VIFYKQPTTLHLTLTAAPDLNPDANGR---PSPVVVRVYQLKDDSAFESADFFALLDDDEEA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378978478 101 LAADLLASRDVVIGPGGDASLNMPLEAEATFVAVVGLFRHPDtqRNTWKQVLAREELDPDKPRIFTAEHNQLRLRPEAAK 180
Cdd:COG3521   91 LGADLLSVKELTLLPGESKTLDLPLDPEARYIGVVALFRDPD--GARWRLVIPVPELDSDGKLTIELGGNAITLVPEKEV 168
T6SS-SciN pfam12790
Type VI secretion lipoprotein, VasD, EvfM, TssJ, VC_A0113; One of the virulence mechanisms of ...
 47-170 4.79e-32

Type VI secretion lipoprotein, VasD, EvfM, TssJ, VC_A0113; One of the virulence mechanisms of E coli is the production of toxins which it produces from dedicated machineries called secretion systems. Seven secretion systems have been described, which assemble from 3 to up to more than 20 subunits. These secretion systems derive from or have co-evolved with bacterial organelles such as ABC transporters (type I), type IV pili (type 2), flagella (type 3), or conjugative machines (type IV). The type VI secretion system (T6SS) is present in most pathogens that have contact with animals, plants, or humans. SciN is a lipoprotein tethered to the outer membrane and expressed in the periplasm of E coli and is essential for T6S-dependent secretion of the Hcp-like SciD protein and for biofilm formation.


Pssm-ID: 432786  Cd Length: 120  Bit Score: 111.53  E-value: 4.79e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378978478   47 TLHLDFTAREALNTDArenHSLSEPVVVRIYQLKDRQTFDRLVYQQLLEEGDILLAADLLASRDVVIGPGGDASLNMPLE 126
Cdd:pfam12790   2 TLDLTLVAAADLNPDE---NGRPSPVVVRVYQLKDDSAFNAADFFSLYDDDKAALGADLVAVDEFILRPGETRTLSLPLD 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 378978478  127 AEATFVAVVGLFRHPDtqRNTWKQVLAREELDPDKPRIFTAEHN 170
Cdd:pfam12790  79 PGARYVGVVAAYRDLD--NARWRLVIPIPEAGEKNPLTVELDAN 120
VI_chp_3 TIGR03352
type VI secretion lipoprotein, VC_A0113 family; Work by Mougous, et al. (2006), describes ...
 39-151 3.25e-15

type VI secretion lipoprotein, VC_A0113 family; Work by Mougous, et al. (2006), describes IAHP-related loci as a type VI secretion system (). This protein family is associated with type VI secretion loci, although not treated explicitly by Mougous, et al. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274535  Cd Length: 130  Bit Score: 68.43  E-value: 3.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378978478   39 AVFYKKINTLHLDFTAREALNTDARENHSlsePVVVRIYQLKDRQTFDRLVYQQLLEEGDILLAADLLASRDVVIGPGGD 118
Cdd:TIGR03352   3 APPPKEPTYVTLTLTAAPDVNPDADGRAS---PVVVRVYELKSDTKFEAADFFALTEDAKKALGDDLIETDEIILLPGEK 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 378978478  119 ASLNMPLEAEATFVAVVGLFRHPDTQRntWKQV 151
Cdd:TIGR03352  80 RKITITLDEGTRYIGVVAAYRDIDNAE--WRVV 110
 
Name Accession Description Interval E-value
COG3521 COG3521
Predicted component of the type VI protein secretion system [Intracellular trafficking, ...
 21-180 2.21e-51

Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442743  Cd Length: 168  Bit Score: 162.45  E-value: 2.21e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378978478  21 SGCGLTQRVSegtksafnAVFYKKINTLHLDFTAREALNTDARENhslSEPVVVRIYQLKDRQTFDRLVYQQLLEEGDIL 100
Cdd:COG3521   22 AGCGSTQKVT--------VIFYKQPTTLHLTLTAAPDLNPDANGR---PSPVVVRVYQLKDDSAFESADFFALLDDDEEA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378978478 101 LAADLLASRDVVIGPGGDASLNMPLEAEATFVAVVGLFRHPDtqRNTWKQVLAREELDPDKPRIFTAEHNQLRLRPEAAK 180
Cdd:COG3521   91 LGADLLSVKELTLLPGESKTLDLPLDPEARYIGVVALFRDPD--GARWRLVIPVPELDSDGKLTIELGGNAITLVPEKEV 168
T6SS-SciN pfam12790
Type VI secretion lipoprotein, VasD, EvfM, TssJ, VC_A0113; One of the virulence mechanisms of ...
 47-170 4.79e-32

Type VI secretion lipoprotein, VasD, EvfM, TssJ, VC_A0113; One of the virulence mechanisms of E coli is the production of toxins which it produces from dedicated machineries called secretion systems. Seven secretion systems have been described, which assemble from 3 to up to more than 20 subunits. These secretion systems derive from or have co-evolved with bacterial organelles such as ABC transporters (type I), type IV pili (type 2), flagella (type 3), or conjugative machines (type IV). The type VI secretion system (T6SS) is present in most pathogens that have contact with animals, plants, or humans. SciN is a lipoprotein tethered to the outer membrane and expressed in the periplasm of E coli and is essential for T6S-dependent secretion of the Hcp-like SciD protein and for biofilm formation.


Pssm-ID: 432786  Cd Length: 120  Bit Score: 111.53  E-value: 4.79e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378978478   47 TLHLDFTAREALNTDArenHSLSEPVVVRIYQLKDRQTFDRLVYQQLLEEGDILLAADLLASRDVVIGPGGDASLNMPLE 126
Cdd:pfam12790   2 TLDLTLVAAADLNPDE---NGRPSPVVVRVYQLKDDSAFNAADFFSLYDDDKAALGADLVAVDEFILRPGETRTLSLPLD 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 378978478  127 AEATFVAVVGLFRHPDtqRNTWKQVLAREELDPDKPRIFTAEHN 170
Cdd:pfam12790  79 PGARYVGVVAAYRDLD--NARWRLVIPIPEAGEKNPLTVELDAN 120
VI_chp_3 TIGR03352
type VI secretion lipoprotein, VC_A0113 family; Work by Mougous, et al. (2006), describes ...
 39-151 3.25e-15

type VI secretion lipoprotein, VC_A0113 family; Work by Mougous, et al. (2006), describes IAHP-related loci as a type VI secretion system (). This protein family is associated with type VI secretion loci, although not treated explicitly by Mougous, et al. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274535  Cd Length: 130  Bit Score: 68.43  E-value: 3.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378978478   39 AVFYKKINTLHLDFTAREALNTDARENHSlsePVVVRIYQLKDRQTFDRLVYQQLLEEGDILLAADLLASRDVVIGPGGD 118
Cdd:TIGR03352   3 APPPKEPTYVTLTLTAAPDVNPDADGRAS---PVVVRVYELKSDTKFEAADFFALTEDAKKALGDDLIETDEIILLPGEK 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 378978478  119 ASLNMPLEAEATFVAVVGLFRHPDTQRntWKQV 151
Cdd:TIGR03352  80 RKITITLDEGTRYIGVVAAYRDIDNAE--WRVV 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH