NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|378976663|ref|YP_005224804|]
View 

aspartate carbamoyltransferase catalytic subunit [Klebsiella pneumoniae subsp. pneumoniae HS11286]

Protein Classification

aspartate carbamoyltransferase( domain architecture ID 11489502)

aspartate carbamoyltransferase catalyzes the conversion of aspartate and carbamoyl phosphate to carbamoyl-L-aspartate, the first unique step of pyrimidine biosynthesis

CATH:  3.40.50.1370
EC:  2.1.3.2
Gene Ontology:  GO:0004070|GO:0006520|GO:0016597|GO:0016743
SCOP:  4000794

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
asp_carb_tr TIGR00670
aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB ...
 8-306 3.56e-166

aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB encodes the catalytic chain of aspartate carbamoyltransferase, an enzyme of pyrimidine biosynthesis, which organizes into trimers. In some species, including E. coli and the Archaea but excluding Bacillus subtilis, a regulatory subunit PyrI is also present in an allosterically regulated hexameric holoenzyme. Several molecular weight classes of ATCase are described in MEDLINE:96303527 and often vary within taxa. PyrB and PyrI are fused in Thermotoga maritima.Ornithine carbamoyltransferases are in the same superfamily and form an outgroup. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


:

Pssm-ID: 273209 [Multi-domain]  Cd Length: 301  Bit Score: 463.75  E-value: 3.56e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663    8 KHIISINDLSREDLELVLATAAKLKANPQPE----LLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLg 83
Cdd:TIGR00670   1 RHLISISDLSREEIELLLETARELEQVLNGKeplkLLKGKILANLFFEPSTRTRLSFETAMKRLGGSVVNFSDSETSSV- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   84 KKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGgVPVLNAGDGANQHPTQTLLDLFTIQETQGRLENLNVAMVGD 163
Cdd:TIGR00670  80 AKGETLADTIKTLSGYVDAIVIRHPLEGAARLAAEVSE-VPVINAGDGSNQHPTQTLLDLYTIYEEFGRLDGLKIALVGD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  164 LKYGRTVHSLTQALAKFnGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSAIDDVMAEVDILYMTRVQKERL-DPSEYA 242
Cdd:TIGR00670 159 LKYGRTVHSLAEALTRF-GVEVYLISPEELRMPKEILEELKAKGIKVRETESLEEVIDEADVLYVTRIQKERFpDPEEYE 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 378976663  243 NVKAQFVLRAADLEGARANMKVLHPLPRIDEITTDVDKTPHAWYFQQAGNGIFARQALLALVLN 306
Cdd:TIGR00670 238 KVKGSYGITLERLEAAKKGVIIMHPLPRVDEIDPSVDDTPHAKYFKQAFNGVPVRMALLALLLG 301
 
Name Accession Description Interval E-value
asp_carb_tr TIGR00670
aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB ...
 8-306 3.56e-166

aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB encodes the catalytic chain of aspartate carbamoyltransferase, an enzyme of pyrimidine biosynthesis, which organizes into trimers. In some species, including E. coli and the Archaea but excluding Bacillus subtilis, a regulatory subunit PyrI is also present in an allosterically regulated hexameric holoenzyme. Several molecular weight classes of ATCase are described in MEDLINE:96303527 and often vary within taxa. PyrB and PyrI are fused in Thermotoga maritima.Ornithine carbamoyltransferases are in the same superfamily and form an outgroup. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 273209 [Multi-domain]  Cd Length: 301  Bit Score: 463.75  E-value: 3.56e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663    8 KHIISINDLSREDLELVLATAAKLKANPQPE----LLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLg 83
Cdd:TIGR00670   1 RHLISISDLSREEIELLLETARELEQVLNGKeplkLLKGKILANLFFEPSTRTRLSFETAMKRLGGSVVNFSDSETSSV- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   84 KKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGgVPVLNAGDGANQHPTQTLLDLFTIQETQGRLENLNVAMVGD 163
Cdd:TIGR00670  80 AKGETLADTIKTLSGYVDAIVIRHPLEGAARLAAEVSE-VPVINAGDGSNQHPTQTLLDLYTIYEEFGRLDGLKIALVGD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  164 LKYGRTVHSLTQALAKFnGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSAIDDVMAEVDILYMTRVQKERL-DPSEYA 242
Cdd:TIGR00670 159 LKYGRTVHSLAEALTRF-GVEVYLISPEELRMPKEILEELKAKGIKVRETESLEEVIDEADVLYVTRIQKERFpDPEEYE 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 378976663  243 NVKAQFVLRAADLEGARANMKVLHPLPRIDEITTDVDKTPHAWYFQQAGNGIFARQALLALVLN 306
Cdd:TIGR00670 238 KVKGSYGITLERLEAAKKGVIIMHPLPRVDEIDPSVDDTPHAKYFKQAFNGVPVRMALLALLLG 301
pyrB PRK00856
aspartate carbamoyltransferase catalytic subunit;
3-308 7.56e-157

aspartate carbamoyltransferase catalytic subunit;


Pssm-ID: 234849 [Multi-domain]  Cd Length: 305  Bit Score: 440.28  E-value: 7.56e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   3 NPLYQKHIISINDLSREDLELVLATAAKLKANP-----QPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDS 77
Cdd:PRK00856   1 NPLKMKHLLSIEDLSREEIELLLDTAEEFKEVLrrevkKVPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  78 ANTSlgKKGETLADTISVISTY-VDAIVMRHPQEGAARLATEFSGgVPVLNAGDGANQHPTQTLLDLFTIQETQGRLENL 156
Cdd:PRK00856  81 TSSV--SKGETLADTIRTLSAMgADAIVIRHPQSGAARLLAESSD-VPVINAGDGSHQHPTQALLDLLTIREEFGRLEGL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 157 NVAMVGDLKYGRTVHSLTQALAKFnGNRFYFIAPDALaMPQYILDmldekgiaWSLHSAIDDVMAEVDILYMTRVQKERL 236
Cdd:PRK00856 158 KVAIVGDIKHSRVARSNIQALTRL-GAEVRLIAPPTL-LPEGMPE--------YGVHTDLDEVIEDADVVMMLRVQKERM 227

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 378976663 237 D---PSEYANVKAQFVLRAADLEGARANMKVLHPLP--RIDEITTDVDKTPHAWYFQQAGNGIFARQALLALVLNSE 308
Cdd:PRK00856 228 DgglLPSYEEYKRSYGLTAERLALAKPDAIVMHPGPvnRGVEIASDVADGPQSVIFEQVTNGVAVRMAVLELLLGGR 304
PyrB COG0540
Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; ...
 3-308 3.25e-152

Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; Aspartate carbamoyltransferase, catalytic subunit is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440306 [Multi-domain]  Cd Length: 306  Bit Score: 428.32  E-value: 3.25e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   3 NPLYQKHIISINDLSREDLELVLATAAKLKANPQPE----LLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSdSA 78
Cdd:COG0540    1 MSFKMRHLLSIEDLSREEIEELLDTAEEFKEVLRPIkkvpLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFS-AS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  79 NTSLgKKGETLADTISVISTY-VDAIVMRHPQEGAARLATEFSGgVPVLNAGDGANQHPTQTLLDLFTIQETQGRLENLN 157
Cdd:COG0540   80 TSSV-SKGESLADTIRTLEAYgADAIVIRHPQEGAARLLAEHVD-VPVINAGDGAHEHPTQALLDLYTIREEFGRLDGLK 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 158 VAMVGDLKYGRTVHSLTQALAKFnGNRFYFIAPDALaMPQYIldmlDEKGIawSLHSAIDDVMAEVDILYMTRVQKERLD 237
Cdd:COG0540  158 VAIVGDLKHSRVARSNIKALSKL-GAEVTLVAPPTL-LPEEI----EELGV--EVTTDLDEALPDADVVYMLRIQKERFT 229

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 378976663 238 ---PSEYANVKAQFVLRAADLEGARANMKVLHPLP--RIDEITTDVDKTPHAWYFQQAGNGIFARQALLALVLNSE 308
Cdd:COG0540  230 dglFPSYREYKRSYGLTAERLALAKPDAIVMHPGPrnRGVEIDSDVDDTPRSVIFEQVTNGVAVRMALLYLLLGGE 305
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
9-148 1.11e-58

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 184.55  E-value: 1.11e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663    9 HIISINDLSREDLELVLATAAKLKANPQ----PELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFsDSANTSLGk 84
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKrgkkLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYL-SSSDIQLS- 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 378976663   85 KGETLADTISVISTYVDAIVMRHP-QEGAARLAtEFSgGVPVLNAGdGANQHPTQTLLDLFTIQE 148
Cdd:pfam02729  79 SGESLADTARVLSRYVDAIVIRHFgHEDLEELA-EYA-SVPVINAG-GDHEHPTQALADLLTIRE 140
 
Name Accession Description Interval E-value
asp_carb_tr TIGR00670
aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB ...
 8-306 3.56e-166

aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB encodes the catalytic chain of aspartate carbamoyltransferase, an enzyme of pyrimidine biosynthesis, which organizes into trimers. In some species, including E. coli and the Archaea but excluding Bacillus subtilis, a regulatory subunit PyrI is also present in an allosterically regulated hexameric holoenzyme. Several molecular weight classes of ATCase are described in MEDLINE:96303527 and often vary within taxa. PyrB and PyrI are fused in Thermotoga maritima.Ornithine carbamoyltransferases are in the same superfamily and form an outgroup. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 273209 [Multi-domain]  Cd Length: 301  Bit Score: 463.75  E-value: 3.56e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663    8 KHIISINDLSREDLELVLATAAKLKANPQPE----LLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLg 83
Cdd:TIGR00670   1 RHLISISDLSREEIELLLETARELEQVLNGKeplkLLKGKILANLFFEPSTRTRLSFETAMKRLGGSVVNFSDSETSSV- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   84 KKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGgVPVLNAGDGANQHPTQTLLDLFTIQETQGRLENLNVAMVGD 163
Cdd:TIGR00670  80 AKGETLADTIKTLSGYVDAIVIRHPLEGAARLAAEVSE-VPVINAGDGSNQHPTQTLLDLYTIYEEFGRLDGLKIALVGD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  164 LKYGRTVHSLTQALAKFnGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSAIDDVMAEVDILYMTRVQKERL-DPSEYA 242
Cdd:TIGR00670 159 LKYGRTVHSLAEALTRF-GVEVYLISPEELRMPKEILEELKAKGIKVRETESLEEVIDEADVLYVTRIQKERFpDPEEYE 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 378976663  243 NVKAQFVLRAADLEGARANMKVLHPLPRIDEITTDVDKTPHAWYFQQAGNGIFARQALLALVLN 306
Cdd:TIGR00670 238 KVKGSYGITLERLEAAKKGVIIMHPLPRVDEIDPSVDDTPHAKYFKQAFNGVPVRMALLALLLG 301
pyrB PRK00856
aspartate carbamoyltransferase catalytic subunit;
3-308 7.56e-157

aspartate carbamoyltransferase catalytic subunit;


Pssm-ID: 234849 [Multi-domain]  Cd Length: 305  Bit Score: 440.28  E-value: 7.56e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   3 NPLYQKHIISINDLSREDLELVLATAAKLKANP-----QPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDS 77
Cdd:PRK00856   1 NPLKMKHLLSIEDLSREEIELLLDTAEEFKEVLrrevkKVPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSAS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  78 ANTSlgKKGETLADTISVISTY-VDAIVMRHPQEGAARLATEFSGgVPVLNAGDGANQHPTQTLLDLFTIQETQGRLENL 156
Cdd:PRK00856  81 TSSV--SKGETLADTIRTLSAMgADAIVIRHPQSGAARLLAESSD-VPVINAGDGSHQHPTQALLDLLTIREEFGRLEGL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 157 NVAMVGDLKYGRTVHSLTQALAKFnGNRFYFIAPDALaMPQYILDmldekgiaWSLHSAIDDVMAEVDILYMTRVQKERL 236
Cdd:PRK00856 158 KVAIVGDIKHSRVARSNIQALTRL-GAEVRLIAPPTL-LPEGMPE--------YGVHTDLDEVIEDADVVMMLRVQKERM 227

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 378976663 237 D---PSEYANVKAQFVLRAADLEGARANMKVLHPLP--RIDEITTDVDKTPHAWYFQQAGNGIFARQALLALVLNSE 308
Cdd:PRK00856 228 DgglLPSYEEYKRSYGLTAERLALAKPDAIVMHPGPvnRGVEIASDVADGPQSVIFEQVTNGVAVRMAVLELLLGGR 304
PyrB COG0540
Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; ...
 3-308 3.25e-152

Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; Aspartate carbamoyltransferase, catalytic subunit is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440306 [Multi-domain]  Cd Length: 306  Bit Score: 428.32  E-value: 3.25e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   3 NPLYQKHIISINDLSREDLELVLATAAKLKANPQPE----LLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSdSA 78
Cdd:COG0540    1 MSFKMRHLLSIEDLSREEIEELLDTAEEFKEVLRPIkkvpLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFS-AS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  79 NTSLgKKGETLADTISVISTY-VDAIVMRHPQEGAARLATEFSGgVPVLNAGDGANQHPTQTLLDLFTIQETQGRLENLN 157
Cdd:COG0540   80 TSSV-SKGESLADTIRTLEAYgADAIVIRHPQEGAARLLAEHVD-VPVINAGDGAHEHPTQALLDLYTIREEFGRLDGLK 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 158 VAMVGDLKYGRTVHSLTQALAKFnGNRFYFIAPDALaMPQYIldmlDEKGIawSLHSAIDDVMAEVDILYMTRVQKERLD 237
Cdd:COG0540  158 VAIVGDLKHSRVARSNIKALSKL-GAEVTLVAPPTL-LPEEI----EELGV--EVTTDLDEALPDADVVYMLRIQKERFT 229

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 378976663 238 ---PSEYANVKAQFVLRAADLEGARANMKVLHPLP--RIDEITTDVDKTPHAWYFQQAGNGIFARQALLALVLNSE 308
Cdd:COG0540  230 dglFPSYREYKRSYGLTAERLALAKPDAIVMHPGPrnRGVEIDSDVDDTPRSVIFEQVTNGVAVRMALLYLLLGGE 305
PLN02527 PLN02527
aspartate carbamoyltransferase
 8-305 2.54e-113

aspartate carbamoyltransferase


Pssm-ID: 178142 [Multi-domain]  Cd Length: 306  Bit Score: 329.79  E-value: 2.54e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   8 KHIISINDLSREDLELVLATAAKL----KANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLG 83
Cdd:PLN02527   1 SDVIEAQQFDREMLELLFEVAREMekveRGSPGSQMLKGYLMATLFYEPSTRTRLSFESAMKRLGGEVLTTENAGEFSSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  84 KKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGgVPVLNAGDGANQHPTQTLLDLFTIQETQGRLENLNVAMVGD 163
Cdd:PLN02527  81 AKGETLEDTIRTVEGYSDIIVLRHFESGAARRAAATAE-IPVINAGDGPGQHPTQALLDVYTIQREIGRLDGIKVGLVGD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 164 LKYGRTVHSLTQALAKFNGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSAIDDVMAEVDILYMTRVQKERLD--PSEY 241
Cdd:PLN02527 160 LANGRTVRSLAYLLAKYEDVKIYFVAPDVVKMKDDIKDYLTSKGVEWEESSDLMEVASKCDVLYQTRIQRERFGerIDLY 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 378976663 242 ANVKAQFVLRAADLEGARANMKVLHPLPRIDEITTDVDKTPHAWYFQQAGNGIFARQALLALVL 305
Cdd:PLN02527 240 EAARGKYIVDKKVMDVLPKHAVVMHPLPRLDEITTDVDSDPRAAYFRQAKNGLFIRMALLKLLL 303
PRK08192 PRK08192
aspartate carbamoyltransferase; Provisional
 9-308 6.68e-89

aspartate carbamoyltransferase; Provisional


Pssm-ID: 169269 [Multi-domain]  Cd Length: 338  Bit Score: 268.90  E-value: 6.68e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   9 HIISINDLSREDLELVLATAAKLkanpQPELLKHK--------VIASCFFEASTRTRLSFETSMHRLGASV---VGFSDS 77
Cdd:PRK08192   7 HILSVNQLDRDAIQRIFNVADRM----EPYALREKrtrvlegaILGNLFFEPSTRTRVSFGCAFNLLGGHVretTGMASS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  78 ANTslgkKGETLADTISVISTYVDAIVMRHPQEGAARlatEFSGG--VPVLNAGDGANQHPTQTLLDLFTIQ---ETQGR 152
Cdd:PRK08192  83 SLS----KGESLYDTARVLSTYSDVIAMRHPDAGSVK---EFAEGsrVPVINGGDGSNEHPTQALLDLFTIQkelAHAGR 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 153 -LENLNVAMVGDLKYGRTVHSLTQALAKFNGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSAIDDVMAEVDILYMTRV 231
Cdd:PRK08192 156 gIDGMHIAMVGDLKFGRTVHSLSRLLCMYKNVSFTLVSPKELAMPDYVISDIENAGHKITITDQLEGNLDKADILYLTRI 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 232 QKERLDPSEYANV-KAQFVL-RAADLEGARANMKVLHPLPR-----IDEITTDVDKTPHAWYFQQAGNGIFARQALLALV 304
Cdd:PRK08192 236 QEERFPSQEEANKyRGKFRLnQSIYTQHCKSNTVIMHPLPRdsraqANELDNDLNSHPNLAIFRQADNGLLIRMALFALT 315


                 ....
gi 378976663 305 LNSE 308
Cdd:PRK08192 316 LGVD 319
PRK11891 PRK11891
aspartate carbamoyltransferase; Provisional
 9-308 1.44e-73

aspartate carbamoyltransferase; Provisional


Pssm-ID: 183362 [Multi-domain]  Cd Length: 429  Bit Score: 232.45  E-value: 1.44e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   9 HIISINDLSREDLELVLATAAKLkanpQP--------ELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANT 80
Cdd:PRK11891  89 QLLSVDQFSRDSVEALFRVADVM----QPiarrqkisRVLEGAVLGNLFFEASTRTRVSFGAAFCRLGGSVCDTTGFTFS 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  81 SLGKkGETLADTISVISTYVDAIVMRHPQEG-AARLATefSGGVPVLNAGDGANQHPTQTLLDLFTIQETQGRLENL--- 156
Cdd:PRK11891 165 SMAK-GESIYDTSRVMSGYVDALVIRHPEQGsVAEFAR--ATNLPVINGGDGPGEHPSQALLDLYTIQREFSRLGKIvdg 241

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 157 -NVAMVGDLKYGRTVHSLTQALAKFNGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSAIDDVMAEVDILYMTRVQKER 235
Cdd:PRK11891 242 aHIALVGDLKYGRTVHSLVKLLALYRGLKFTLVSPPTLEMPAYIVEQISRNGHVIEQTDDLAAGLRGADVVYATRIQKER 321

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 378976663 236 LDPSEYANVKAQFVLRAADLEGA-RANMKVLHPLPR-----IDEITTDVDKTPHAWYFQQAGNGIFARQALLALVLNSE 308
Cdd:PRK11891 322 FADESFEGYTPDFQINQALVDAVcKPDTLIMHPLPRdsrpgANDLSTDLNRDPRLAIFRQTDNGIPVRMAIFAVLLGVE 400
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
9-148 1.11e-58

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 184.55  E-value: 1.11e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663    9 HIISINDLSREDLELVLATAAKLKANPQ----PELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFsDSANTSLGk 84
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKrgkkLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYL-SSSDIQLS- 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 378976663   85 KGETLADTISVISTYVDAIVMRHP-QEGAARLAtEFSgGVPVLNAGdGANQHPTQTLLDLFTIQE 148
Cdd:pfam02729  79 SGESLADTARVLSRYVDAIVIRHFgHEDLEELA-EYA-SVPVINAG-GDHEHPTQALADLLTIRE 140
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 3-306 8.51e-58

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 188.34  E-value: 8.51e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   3 NPLYQKHIISINDLSREDLELVLATAAKLKANPQ----PELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVgFSDSA 78
Cdd:COG0078    1 TNLKGRHFLSLLDLTPEELRALLDLAAELKAKRKagipHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAI-YLDPG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  79 NTSLGkKGETLADTISVISTYVDAIVMR-HPQEGAARLAtEFSgGVPVLNAGDgANQHPTQTLLDLFTIQETQGRLENLN 157
Cdd:COG0078   80 DSQLG-RGESIKDTARVLSRYVDGIMIRtFGHETLEELA-KYA-GVPVINGLT-DLFHPCQALADLLTIREHFGKLKGLK 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 158 VAMVGDlkyGRTV-HSLTQALAKFnGNRFYFIAPDALAMPQYILDMLDEkgIAWSLHSAI---DDVMAEV---DILY--- 227
Cdd:COG0078  156 VAYVGD---GNNVaNSLLLAAAKL-GMDVRIATPEGYEPDPEIVAKAKE--IAAESGGSItitHDPAEAVkgaDVVYtdv 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 228 ---MTrvqkerlDPSEYANVKAQFvlraAD-------LEGARANMKVLHPLP--RIDEITTDV-DKtPHAWYFQQAGNGI 294
Cdd:COG0078  230 wvsMG-------QEEEAEERIKAF----KPyqvneelMALAKPDAIFMHCLPahRGEEVTDEViDG-PQSVVFDEAENRL 297

                        330
                 ....*....|..
gi 378976663 295 FARQALLALVLN 306
Cdd:COG0078  298 HAQKALLAWLLG 309
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 8-305 1.54e-49

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 166.81  E-value: 1.54e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   8 KHIISINDLSREDLELVLATAAKLKANPQ----PELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVgFSDSANTSLG 83
Cdd:PRK00779   5 RHFLSLDDLSPEELEELLDLAAELKKKRKagepHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAI-FLSPRDTQLG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  84 kKGETLADTISVISTYVDAIVMR-HPQEGAARLAtEFSgGVPVLNA-GDGAnqHPTQTLLDLFTIQETQGRLENLNVAMV 161
Cdd:PRK00779  84 -RGEPIEDTARVLSRYVDAIMIRtFEHETLEELA-EYS-TVPVINGlTDLS--HPCQILADLLTIYEHRGSLKGLKVAWV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 162 GDlkyGRTV-HSLTQALAKFnGNRFYFIAPDALAMPQYILDMLDEK--GIAWSLHSAIDDVmAEVDILYmTRV------- 231
Cdd:PRK00779 159 GD---GNNVaNSLLLAAALL-GFDLRVATPKGYEPDPEIVEKIAKEtgASIEVTHDPKEAV-KGADVVY-TDVwvsmgqe 232

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 378976663 232 --QKERLdpseyaNVKAQFVLRAADLEGARANMKVLHPLP--RIDEITTDVDKTPHAWYFQQAGNGIFARQALLALVL 305
Cdd:PRK00779 233 aeAEERL------KAFAPYQVNEELMALAKPDAIFMHCLPahRGEEVTDEVIDGPQSVVWDEAENRLHAQKALLAWLL 304
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 8-306 7.04e-44

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 152.12  E-value: 7.04e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663    8 KHIISINDLSREDLELVLATAAKLK----ANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSaNTSLG 83
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKkgkkKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPN-DLQLG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   84 kKGETLADTISVISTYVDAIVMR-HPQEGAARLAtEFSgGVPVLNA-GDGAnqHPTQTLLDLFTIQETQGRLENLNVAMV 161
Cdd:TIGR00658  80 -RGESIKDTARVLSRYVDGIMARvYKHEDVEELA-KYA-SVPVINGlTDLF--HPCQALADLLTIIEHFGKLKGVKVVYV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  162 GDlkyGRTV-HSLTQALAKFnGNRFYFIAPDALAMPQYILDM----LDEKGIAWSLHSAIDDVMAEVDILYmTRVQKERL 236
Cdd:TIGR00658 155 GD---GNNVcNSLMLAGAKL-GMDVVVATPEGYEPDADIVKKaqeiAKENGGSVELTHDPVEAVKGADVIY-TDVWVSMG 229

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 378976663  237 DPSEYANVKAQFV---LRAADLEGARANMKVLHPLP--RIDEITTDVDKTPHAWYFQQAGNGIFARQALLALVLN 306
Cdd:TIGR00658 230 EEDKKEERLKLFRpyqVNEELMELAKPEVIFMHCLPahRGEEVTDEVIEGPHSIVFDQAENRLHAQKAVMVALLG 304
pyrB PRK13376
bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase ...
 13-304 2.09e-38

bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; Provisional


Pssm-ID: 237369 [Multi-domain]  Cd Length: 525  Bit Score: 142.21  E-value: 2.09e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  13 INDLSREDLELVLATAAKLKANPQP-------ELLKHKV-IASCFFEASTRTRLSFETS--MHRlGASVVGFsDSANTSL 82
Cdd:PRK13376  13 IEDLSVEEQLFLYEKTRELKQRWYEgedvsefRIKKRDVgIYIVFVEPSTRTKESFINAakFHK-NVKVNIF-DSEHSSF 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  83 GKKgETLADTISVISTYVDA--IVMRHPQEGAARL----ATEFS--GGVPV---LNAGDGANQHPTQTLLDLFTIQEtQG 151
Cdd:PRK13376  91 NKQ-ESYTDTFNMLTGYSDYsiFIVRTRLEGVCRLleekVSEFAsrNGIEVpafINAGDGKHEHPTQELLDEFTFLE-QN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 152 RLEN--LNVAMVGDLKYGRTVHSLTQALAKFNGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSAIDDVMAEVD---IL 226
Cdd:PRK13376 169 NFDNsfIHIALVGDLLHGRTVHSKVNGLKIFKNVKVDLIAPEELAMPEHYVEKMKKNGFEVRIFSSIEEYLSQKDvakIW 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 227 YMTRVQKERL--DPSEYANV-KAQFVLRAADLEGARANMKVLHPLPR--ID-EITTDVDKTPHAWYFQQAGNGIFARQAL 300
Cdd:PRK13376 249 YFTRLQLERMgeDILEKEHIlRKAVTFRKEFLDKLPEGVKFYHPLPRhkVYpTIPTFLDTLPLNGWETQAINGYWVRIVL 328


                 ....
gi 378976663 301 LALV 304
Cdd:PRK13376 329 LSML 332
pyrB PRK13814
aspartate carbamoyltransferase;
9-305 2.16e-38

aspartate carbamoyltransferase;


Pssm-ID: 139876 [Multi-domain]  Cd Length: 310  Bit Score: 137.93  E-value: 2.16e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   9 HIISINDLSREDLELVLATA-----AKLKANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVgfSDSANTSLG 83
Cdd:PRK13814   7 HLLNMRSLTRDHIEKLIQRAnyfltQGMEKNSVFETLKGHVVANLFFEPSTRTRNSFEIAAKRLGAMVL--NPNLKISAI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  84 KKGETLADTISVISTY-VDAIVMRHPQ-EGAARLATEFSGGVpVLNAGDGANQHPTQTLLDLFTIQETQGRLENLNVAMV 161
Cdd:PRK13814  85 SKGETLFDTIKTLEAMgVYFFIVRHSEnETPEQIAKQLSSGV-VINAGDGNHQHPSQALIDLMTIKQHKPHWNKLCVTII 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 162 GDLKYGRTVHSLTQALAKFNGNRFYFIAPDALaMPQYILDMLDEKgiawslHSAIDDVMAEVDILYMTRVQKERLDPS-E 240
Cdd:PRK13814 164 GDIRHSRVANSLMDGLVTMGVPEIRLVGPSSL-LPDKVGNDSIKK------FTELKPSLLNSDVIVTLRLQKERHDNSvD 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 378976663 241 YANVKAQFVLRAADLEGARANMKVLHPLP--RIDEITTDVDKTPHAWYFQQAGNGIFARQALLALVL 305
Cdd:PRK13814 237 IDAFRGSFRLTPEKLYSAKPDAIVMHPGPvnREVEINSDVADNQQSVILQQVRNGVAMRMAVLELFL 303
PRK02102 PRK02102
ornithine carbamoyltransferase; Validated
 1-292 1.53e-32

ornithine carbamoyltransferase; Validated


Pssm-ID: 179366 [Multi-domain]  Cd Length: 331  Bit Score: 122.69  E-value: 1.53e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   1 MANPLYQKHIISINDLSREDLELVLATAAKLKAN-----PQPeLLKHKVIASCFFEASTRTRLSFETSMHRLGASVVgFS 75
Cdd:PRK02102   1 MAFNLKGRSFLKLLDFTPEEIEYLIDLSIELKAAkkagiEHQ-YLEGKNIALIFEKTSTRTRCAFEVAAIDLGAHVT-YL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  76 DSANTSLGKKgETLADTISVISTYVDAIVMR-HPQEGAARLAtEFSgGVPVLNAGDGAnQHPTQTLLDLFTIQETQGRLE 154
Cdd:PRK02102  79 GPNDSQLGKK-ESIEDTARVLGRMYDGIEYRgFKQEIVEELA-KYS-GVPVWNGLTDE-WHPTQMLADFMTMKEHFGPLK 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 155 NLNVAMVGDlkyGR--TVHSLTQALAKFnGNRFYFIAPDAL----AMPQYILDMLDEKGIAWSLHSAIDDVMAEVDILYm 228
Cdd:PRK02102 155 GLKLAYVGD---GRnnMANSLMVGGAKL-GMDVRICAPKELwpeeELVALAREIAKETGAKITITEDPEEAVKGADVIY- 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 229 TRVQKERLDPSEYANVKAQF--------VLRAAdlegARANMKVLHPLPRID-------------------EITTDVDKT 281
Cdd:PRK02102 230 TDVWVSMGEEDEWEERIKLLkpyqvnmdLMKAT----GNPDVIFMHCLPAFHdtetkvgkeiaekyglkglEVTDEVFES 305

                        330
                 ....*....|.
gi 378976663 282 PHAWYFQQAGN 292
Cdd:PRK02102 306 KYSIVFDEAEN 316
OTCace pfam00185
Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;
157-304 2.20e-30

Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;


Pssm-ID: 425511 [Multi-domain]  Cd Length: 154  Bit Score: 112.32  E-value: 2.20e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  157 NVAMVGDlKYGRTVHSLTQALAKFNGNrFYFIAPDALAMPQYILDML----DEKGIAWSLHSAIDDVMAEVDILYMTRVQ 232
Cdd:pfam00185   1 KIAYVGD-GHNNVAHSLIIAAAKLGMD-VRLATPKGYPPDPEVLDKAkkiaEKSGGSIEITDDPAEAVKGADVVYTDVWQ 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 378976663  233 -----KERLDpsEYAnVKAQFVLRAADLEGARANMKVLHPLP--RIDEITTDVDKTPHAWYFQQAGNGIFARQALLALV 304
Cdd:pfam00185  79 smgqeKEREE--RLK-AFKPYQVNEELMKLAKKDAIFMHCLPahRGEEVTDDVFDGPRSVVFDQAENRLHAQKALLALL 154
PLN02342 PLN02342
ornithine carbamoyltransferase
 8-306 7.71e-30

ornithine carbamoyltransferase


Pssm-ID: 177976 [Multi-domain]  Cd Length: 348  Bit Score: 116.04  E-value: 7.71e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   8 KHIISINDLSREDLELVLATAAKLKA-------NPQPelLKHKVIASCFFEASTRTRLSFETSMHRLGASVVgFSDSANT 80
Cdd:PLN02342  46 KHFLHIDDFDKEEILGLLDRAKEVKAllksgdrSFQP--FKGKSMAMIFTKPSMRTRVSFETGFFLLGGHAL-YLGPDDI 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  81 SLGKKGETlADTISVISTYVDAIVMR---HPQegAARLATEFSggVPVLNAGDGANqHPTQTLLDLFTIQETQGRLENLN 157
Cdd:PLN02342 123 QLGKREET-RDIARVLSRYNDIIMARvfaHQD--VLDLAEYSS--VPVINGLTDYN-HPCQIMADALTIIEHIGRLEGTK 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 158 VAMVGDlkyGRT-VHSLTQALAKFNgnrFYFIA-------PDAlampqYILDMLDEKGIA--WSLHSAIDDVMAeVDILY 227
Cdd:PLN02342 197 VVYVGD---GNNiVHSWLLLAAVLP---FHFVCacpkgyePDA-----KTVEKARAAGISkiEITNDPAEAVKG-ADVVY 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 228 mTRV-----QKErldpsEYANVKAQF---VLRAADLEGARANMKVLHPLP--RIDEITTDVDKTPHAWYFQQAGNGIFAR 297
Cdd:PLN02342 265 -TDVwasmgQKE-----EAEKRKKAFqgfQVNEALMKLAGPQAYFMHCLPaeRGVEVTDGVMEAPNSIVFPQAENRMHAQ 338


                 ....*....
gi 378976663 298 QALLALVLN 306
Cdd:PLN02342 339 NAIMLHQLG 347
PRK14805 PRK14805
ornithine carbamoyltransferase; Provisional
 8-306 1.13e-29

ornithine carbamoyltransferase; Provisional


Pssm-ID: 237819 [Multi-domain]  Cd Length: 302  Bit Score: 114.40  E-value: 1.13e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   8 KHIISINDLSREDLELVLATAAKLKANPQP--ELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVgFSDSANTSLGKK 85
Cdd:PRK14805   2 KHLLSIKELTQQQLLDLLALAKTIKANPAEyrQALAGKSVVMLFEKPSLRTRVSFDIGINKLGGHCL-YLDQQNGALGKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  86 gETLADTISVISTYVDAIVMR----HPQEGAARLATefsggVPVLNA-GDgaNQHPTQTLLDLFTIQETQGRLENLNVAM 160
Cdd:PRK14805  81 -ESVADFAANLSCWADAIVARvfshSTIEQLAEHGS-----VPVINAlCD--LYHPCQALADFLTLAEQFGDVSKVKLAY 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 161 VGDlkyGRTV-HSLTQALAKFnGNRFYFIAPDALAMPQYILDMLDEK----GIAWSLHSAIDDVmAEVDILYmTRVQKER 235
Cdd:PRK14805 153 VGD---GNNVtHSLMYGAAIL-GATMTVICPPGHFPDGQIVAEAQELaaksGGKLVLTSDIEAI-EGHDAIY-TDTWISM 226

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 378976663 236 LDPSEYANVKAQFV---LRAADLEGARANMkVLHPLP--RIDEITTDVDKTPHAWYFQQAGNGIFARQALLALVLN 306
Cdd:PRK14805 227 GDDTPLAEIKAKFApyqVNKALMEKAGATF-VMHCQPahRGVEITSEVMDGEGSLILQQAENRMHAQNAVLVTLLS 301
PRK03515 PRK03515
ornithine carbamoyltransferase subunit I; Provisional
 3-309 1.37e-23

ornithine carbamoyltransferase subunit I; Provisional


Pssm-ID: 179587 [Multi-domain]  Cd Length: 336  Bit Score: 98.63  E-value: 1.37e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   3 NPLYQKHIISINDLSREDLELVLATAAKLKANPQP----ELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSA 78
Cdd:PRK03515   2 NQFYQRHFLRLLDFTPAELNSLLQLAAKLKADKKNgkeeQKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  79 nTSLGKKgETLADTISVISTYVDAIVMR-HPQEGAARLAtEFSgGVPVLNaGDGANQHPTQTLLDLFTIQETQ-GR-LEN 155
Cdd:PRK03515  82 -SQIGHK-ESIKDTARVLGRMYDGIQYRgYGQEIVETLA-EYA-GVPVWN-GLTNEFHPTQLLADLLTMQEHLpGKaFNE 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 156 LNVAMVGDLKyGRTVHSLTQAlAKFNGNRFYFIAPDALaMPQYIL-----DMLDEKGIAWSLHSAIDDVMAEVDILYM-- 228
Cdd:PRK03515 157 MTLAYAGDAR-NNMGNSLLEA-AALTGLDLRLVAPKAC-WPEAALvtecrALAQKNGGNITLTEDIAEGVKGADFIYTdv 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 229 -------TRVQKERLD-PSEYanvkaQFVLRAADLEGaRANMKVLHPLPRID--------------------EITTDVDK 280
Cdd:PRK03515 234 wvsmgepKEVWAERIAlLRPY-----QVNSKMMQLTG-NPQVKFLHCLPAFHddqttlgkkmaeeyglhggmEVTDEVFE 307

                        330       340
                 ....*....|....*....|....*....
gi 378976663 281 TPHAWYFQQAGNGIFARQALLALVLNSEL 309
Cdd:PRK03515 308 SAHSIVFDQAENRLHTIKAVMVATLSKDL 336
PRK04523 PRK04523
N-acetylornithine carbamoyltransferase; Reviewed
 8-306 9.99e-23

N-acetylornithine carbamoyltransferase; Reviewed


Pssm-ID: 235304 [Multi-domain]  Cd Length: 335  Bit Score: 96.36  E-value: 9.99e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   8 KHIISINDLSREDLELVLATAAKLKANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFsDSANTSL----- 82
Cdd:PRK04523   4 KHFLNTQDWSRAELDALLTQAAAFKRNKLGSALKGKSIALVFFNPSLRTRTSFELGAFQLGGHAVVL-QPGKDAWpiefe 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  83 ------GKKGETLADTISVISTYVDAIVMR-HPQ-------------EGAARLATefsggVPVLNAGDGAnqHPTQTLLD 142
Cdd:PRK04523  83 lgavmdGETEEHIREVARVLSRYVDLIGVRaFPKfvdwskdrqdqvlNSFAKYST-----VPVINMETIT--HPCQELAH 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 143 LFTIQETQGRLenlnvamVGDLKYGRTVHSLTQALAKFNGNRFYFIAPdALAM--------PQYIldmLDEKGIAWSLHS 214
Cdd:PRK04523 156 ALALQEHFGTT-------LRGKKYVLTWTYHPKPLNTAVANSALLIAT-RLGMdvtllcptPDYI---LDERYMDWAEQN 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 215 A------------IDDVMAEVDILYmtrvQKERLDPSEYANVKAQFVLRAA--------DLEGARANMKVLHPLP--RID 272
Cdd:PRK04523 225 AaesggsltvshdIDSAYAGADVVY----AKSWGALPFFGNWEPEKPIRDQyqhfivdeRKMALTNNGVFSHCLPlrRNV 300

                        330       340       350
                 ....*....|....*....|....*....|....
gi 378976663 273 EITTDVDKTPHAWYFQQAGNGIFARQALLALVLN 306
Cdd:PRK04523 301 KVTDAVMDSPNCIAIDEAENRLHVQKAIMAALAS 334
PRK04284 PRK04284
ornithine carbamoyltransferase; Provisional
 5-227 2.03e-20

ornithine carbamoyltransferase; Provisional


Pssm-ID: 235269 [Multi-domain]  Cd Length: 332  Bit Score: 89.80  E-value: 2.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   5 LYQKHIISINDLSREDLELVLATAAKLK----ANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVgFSDSANT 80
Cdd:PRK04284   4 LRNRSFLTLLDFTPKEIEYLLDLSEDLKrakyAGIEVQKLKGKNIALIFEKDSTRTRCAFEVAAYDQGAHVT-YLGPTGS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  81 SLGKKgETLADTISVISTYVDAIVMR-HPQEGAARLAtEFSgGVPVLNaGDGANQHPTQTLLDLFTIQET-QGRLENLNV 158
Cdd:PRK04284  83 QMGKK-ESTKDTARVLGGMYDGIEYRgFSQRTVETLA-EYS-GVPVWN-GLTDEDHPTQVLADFLTAKEHlKKPYKDIKF 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 378976663 159 AMVGDlkyGR--TVHSLTQALAKFnGNRFYFIAPDALAMPQYILD----MLDEKGIAWSLHSAIDDVMAEVDILY 227
Cdd:PRK04284 159 TYVGD---GRnnVANALMQGAAIM-GMDFHLVCPKELNPDDELLNkckeIAAETGGKITITDDIDEGVKGSDVIY 229
PRK01713 PRK01713
ornithine carbamoyltransferase; Provisional
 1-294 2.87e-17

ornithine carbamoyltransferase; Provisional


Pssm-ID: 167263 [Multi-domain]  Cd Length: 334  Bit Score: 80.80  E-value: 2.87e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   1 MANPLYQKHIISINDLSREDLELVLATAAKLK----ANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVgFSD 76
Cdd:PRK01713   1 MAFNLKNRHLLSLVNHTEREIKYLLDLSRDLKrakyAGTEQQRLKGKNIALIFEKTSTRTRCAFEVAAYDQGAQVT-YID 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  77 SANTSLGKKgETLADTISVISTYVDAIVMR-HPQEGAARLAtEFSgGVPVLNaGDGANQHPTQTLLDLFT-IQETQGRLE 154
Cdd:PRK01713  80 PNSSQIGHK-ESMKDTARVLGRMYDAIEYRgFKQSIVNELA-EYA-GVPVFN-GLTDEFHPTQMLADVLTmIENCDKPLS 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 155 NLNVAMVGDLKyGRTVHSLTQALAKFnGNRFYFIAPDALAMPQYILDMLD----EKGIAWSLHSAIDDVMAEVDILYMT- 229
Cdd:PRK01713 156 EISYVYIGDAR-NNMGNSLLLIGAKL-GMDVRICAPKALLPEASLVEMCEkfakESGARITVTDDIDKAVKGVDFVHTDv 233

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 378976663 230 --------RVQKERLDPSEYANVKAQFVLRAADlegarANMKVLHPLPRIDEITTDVDKTPHAWYFQQAgNGI 294
Cdd:PRK01713 234 wvsmgeplETWGERIKLLMPYQVTPELMKRTGN-----PKVKFMHCLPAFHNSETKVGRQIAEKYPELA-NGI 300
PRK12562 PRK12562
ornithine carbamoyltransferase subunit F; Provisional
 5-192 2.73e-16

ornithine carbamoyltransferase subunit F; Provisional


Pssm-ID: 105755  Cd Length: 334  Bit Score: 78.18  E-value: 2.73e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   5 LYQKHIISINDLSREDLELVLATAAKLKANP----QPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSAnT 80
Cdd:PRK12562   4 FYKKHFLKLLDFTPAELNSLLQLAAKLKADKkngkEVARLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSG-S 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  81 SLGKKgETLADTISVISTYVDAIVMR-HPQEGAARLAtEFSgGVPVLNaGDGANQHPTQTLLDLFTIQE-TQGRLEN-LN 157
Cdd:PRK12562  83 QIGHK-ESIKDTARVLGRMYDGIQYRgHGQEVVETLA-EYA-GVPVWN-GLTNEFHPTQLLADLLTMQEhLPGKAFNeMT 158

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 378976663 158 VAMVGDLKyGRTVHSLTQAlAKFNGNRFYFIAPDA 192
Cdd:PRK12562 159 LVYAGDAR-NNMGNSMLEA-AALTGLDLRLVAPQA 191
PRK14804 PRK14804
ornithine carbamoyltransferase; Provisional
 8-305 5.15e-13

ornithine carbamoyltransferase; Provisional


Pssm-ID: 173265 [Multi-domain]  Cd Length: 311  Bit Score: 68.51  E-value: 5.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   8 KHIISINDLSREDLELVLATAAKLKANpQPELLKH---KVIASCFFEASTRTRLSFETSMHRLGASVVgFSD--SANTSL 82
Cdd:PRK14804   7 KHLISWEDWSDSEILDLLDFAVHVKKN-RVNYAGHmsgRSLAMLFQKTSTRTRVSFEVAMTEMGGHGI-YLDwmASNFQL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  83 GK---KGETLADTISVI----STYVDAIVMRHPQEgaarlatefsggVPVLNAGDGANqHPTQTLLDLFTI--QETQGRL 153
Cdd:PRK14804  85 SDidlEARYLSRNVSVImarlKKHEDLLVMKNGSQ------------VPVINGCDNMF-HPCQSLADIMTIalDSPEIPL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 154 ENLNVAMVGdlKYGRTVHSLTQALAKFnGNRFYFIAPDALA---MPQYIlDMLDEKG-IAW--SLHSAIDDvmaeVDILY 227
Cdd:PRK14804 152 NQKQLTYIG--VHNNVVNSLIGITAAL-GIHLTLVTPIAAKeniHAQTV-ERAKKKGtLSWemNLHKAVSH----ADYVY 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663 228 M-TRVQKERLDPSEYANVKAQ-------FVLRAADLEgaRANMKVLHPLPrID---EITTDVDKTPHAWYFQQAGNGIFA 296
Cdd:PRK14804 224 TdTWLDMEFFNDPSYADKKKQrmelmmpYQINSSLME--KTNAKVMHDMP-IHagyEITREVVLSDRSIIFQQAENRLDA 300


                 ....*....
gi 378976663 297 RQALLALVL 305
Cdd:PRK14804 301 QKAVILKLL 309
PRK07200 PRK07200
aspartate/ornithine carbamoyltransferase family protein; Validated
 5-160 5.23e-09

aspartate/ornithine carbamoyltransferase family protein; Validated


Pssm-ID: 235961 [Multi-domain]  Cd Length: 395  Bit Score: 56.67  E-value: 5.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663   5 LYQKHIISINDLSREDLELVLATAAKLKA----NPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVV----GFSD 76
Cdd:PRK07200  18 MHEKDFLLTWEKTPDELKAVLDVADALRAlreeNISTKVFNSGLGISVFRDNSTRTRFSYASACNLLGLEVQdldeGKSQ 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378976663  77 SANtslgkkGETLADTISVISTYVDAIVMR----------HPQEGAARLATEFSGGV----PVLNAGDGANQHPTQTLLD 142
Cdd:PRK07200  98 IAH------GETVRETANMISFMADVIGIRddmyigkgnaYMREVGAAVDDGYKQGVlpqrPTLVNLQCDIDHPTQSMAD 171

                        170       180
                 ....*....|....*....|.
gi 378976663 143 LFTIQETQGRLENL---NVAM 160
Cdd:PRK07200 172 LLHLIEHFGGLENLkgkKIAM 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH