NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|229324841|ref|YP_002860219|]
View 

NADH dehydrogenase subunit 3 (mitochondrion) [Crassostrea angulata]

Protein Classification

NADH dehydrogenase subunit 3( domain architecture ID 10009588)

NADH dehydrogenase subunit 3 is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that couples the transfer of electrons from NADH to quinone with the translocation of protons across the membrane

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ND3 MTH00148
NADH dehydrogenase subunit 3; Provisional
 1-114 2.47e-38

NADH dehydrogenase subunit 3; Provisional


:

Pssm-ID: 214433 [Multi-domain]  Cd Length: 117  Bit Score: 124.97  E-value: 2.47e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841   1 MSWDLVFLITVLSAIPISVSLGFISLEEDSYDWDKSSPYECGF---VSPKIPgdFSSRFFHLVILFLVWDVEIVLLIPCF 77
Cdd:MTH00148   1 MLSILLSLLFALILSPVLLLLGLVLSKRSYSDREKSSPFECGFdpiSSARSP--FSLRFFLLAILFLVFDVEIVLLFPVL 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 229324841  78 QDLGVWS--AGASPLAIFLLILSLGLYYELMEGTISWTR 114
Cdd:MTH00148  79 QSLGSSFsvWSLTSLFIFLLILILGLFHEWNEGSLDWVS 117
 
Name Accession Description Interval E-value
ND3 MTH00148
NADH dehydrogenase subunit 3; Provisional
 1-114 2.47e-38

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 214433 [Multi-domain]  Cd Length: 117  Bit Score: 124.97  E-value: 2.47e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841   1 MSWDLVFLITVLSAIPISVSLGFISLEEDSYDWDKSSPYECGF---VSPKIPgdFSSRFFHLVILFLVWDVEIVLLIPCF 77
Cdd:MTH00148   1 MLSILLSLLFALILSPVLLLLGLVLSKRSYSDREKSSPFECGFdpiSSARSP--FSLRFFLLAILFLVFDVEIVLLFPVL 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 229324841  78 QDLGVWS--AGASPLAIFLLILSLGLYYELMEGTISWTR 114
Cdd:MTH00148  79 QSLGSSFsvWSLTSLFIFLLILILGLFHEWNEGSLDWVS 117
Oxidored_q4 pfam00507
NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;
35-108 9.33e-13

NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;


Pssm-ID: 459838 [Multi-domain]  Cd Length: 94  Bit Score: 58.97  E-value: 9.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841   35 KSSPYECGFVS---PKIPgdFSSRFFHLVILFLVWDVEIVLLIP---CFQDLGVwsAGASPLAIFLLILSLGLYYELMEG 108
Cdd:pfam00507  16 KLSPYECGFDPvgdARLR--FSVRFYLVAILFLIFDVEVVFLFPwavSFRELGW--FGFVEMLIFIAILLVGLVYAWKKG 91
NuoA COG0838
NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH: ...
 5-112 5.66e-11

NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 3 (chain A) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440600 [Multi-domain]  Cd Length: 117  Bit Score: 55.13  E-value: 5.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841   5 LVFLITVLSAIPISVSLGFIsLEEDSYDWDKSSPYECGFV---SPKIPgdFSSRFFHLVILFLVWDVEIVLLIP---CFQ 78
Cdd:COG0838    9 LIFLLVALGLALAMLLLSRL-LGPKRPNPEKLSPYECGIEpvgDARIR--FSVRYYLVALLFVIFDVEVVFLFPwavVFR 85

                         90       100       110
                 ....*....|....*....|....*....|....
gi 229324841  79 DLGVWsaGASPLAIFLLILSLGLYYELMEGTISW 112
Cdd:COG0838   86 ELGWF--GLIEMLVFIAILLVGLIYAWKKGALEW 117
 
Name Accession Description Interval E-value
ND3 MTH00148
NADH dehydrogenase subunit 3; Provisional
 1-114 2.47e-38

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 214433 [Multi-domain]  Cd Length: 117  Bit Score: 124.97  E-value: 2.47e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841   1 MSWDLVFLITVLSAIPISVSLGFISLEEDSYDWDKSSPYECGF---VSPKIPgdFSSRFFHLVILFLVWDVEIVLLIPCF 77
Cdd:MTH00148   1 MLSILLSLLFALILSPVLLLLGLVLSKRSYSDREKSSPFECGFdpiSSARSP--FSLRFFLLAILFLVFDVEIVLLFPVL 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 229324841  78 QDLGVWS--AGASPLAIFLLILSLGLYYELMEGTISWTR 114
Cdd:MTH00148  79 QSLGSSFsvWSLTSLFIFLLILILGLFHEWNEGSLDWVS 117
ND3 MTH00042
NADH dehydrogenase subunit 3; Validated
 7-112 1.00e-13

NADH dehydrogenase subunit 3; Validated


Pssm-ID: 177117 [Multi-domain]  Cd Length: 116  Bit Score: 62.31  E-value: 1.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841   7 FLITVLSAIPISVSLGFIS--LEEDSYDWDKSSPYECGF---VSPKIPgdFSSRFFHLVILFLVWDVEIVLLIPCFQDLG 81
Cdd:MTH00042   4 LIFFLLIILILTSLLLLAGhfLPSRSPDLEKSSPYECGFdplNSARLP--FSFRFFLVAILFLLFDLEIALLFPLPPATL 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 229324841  82 VWSAGA--SPLAIFLLILSLGLYYELMEGTISW 112
Cdd:MTH00042  82 ITNPSTllPISLIFLIILTIGLVYEWVNGGLEW 114
ND3 MTH00202
NADH dehydrogenase subunit 3; Provisional
 2-112 1.44e-13

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 214455 [Multi-domain]  Cd Length: 117  Bit Score: 61.93  E-value: 1.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841   2 SWDLVFLITVLSAIpISVSLGFISLEedsyDWDKSSPYECGF---VSPKIPgdFSSRFFHLVILFLVWDVEIVLLIPCFQ 78
Cdd:MTH00202   7 MSILSILISSLLFL-VSWMLSFRSLM----DREKSSPFECGFdpkESARLP--FSMRFFLLAVIFLVFDIEIALLLPLPL 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 229324841  79 DLGVWSAGASPLA--IFLLILSLGLYYELMEGTISW 112
Cdd:MTH00202  80 VLKSSWSKGGLLGgtIFLLILIGGLIHEWKEGSLDW 115
ND3 MTH00012
NADH dehydrogenase subunit 3; Validated
 1-113 3.70e-13

NADH dehydrogenase subunit 3; Validated


Pssm-ID: 164588 [Multi-domain]  Cd Length: 117  Bit Score: 60.64  E-value: 3.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841   1 MSWDLVFLITVLSAIPISVSLGFISLEEDSYDWDKSSPYECGF---VSPKIPgdFSSRFFHLVILFLVWDVEIVLLIPCF 77
Cdd:MTH00012   1 MSLMMIPMMISLILPPLVLGAAWVLAARSTADREKTSPFECGFdphKTARIP--FSLRFFLLAIIFIVFDIEIVLLMPVP 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 229324841  78 QDLGVWSAGASPLA--IFLLILSLGLYYELMEGTISWT 113
Cdd:MTH00012  79 TILMTSTSKTVVYTsiLFLLILVIGLIHEWREGSLDWS 116
Oxidored_q4 pfam00507
NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;
35-108 9.33e-13

NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;


Pssm-ID: 459838 [Multi-domain]  Cd Length: 94  Bit Score: 58.97  E-value: 9.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841   35 KSSPYECGFVS---PKIPgdFSSRFFHLVILFLVWDVEIVLLIP---CFQDLGVwsAGASPLAIFLLILSLGLYYELMEG 108
Cdd:pfam00507  16 KLSPYECGFDPvgdARLR--FSVRFYLVAILFLIFDVEVVFLFPwavSFRELGW--FGFVEMLIFIAILLVGLVYAWKKG 91
ND3 MTH00018
NADH dehydrogenase subunit 3; Validated
 5-112 3.22e-12

NADH dehydrogenase subunit 3; Validated


Pssm-ID: 164592 [Multi-domain]  Cd Length: 113  Bit Score: 58.15  E-value: 3.22e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841   5 LVFLITVLSAIPISVSlgfISLEEDSYDWDKSSPYECGFVSPKIPGD-FSSRFFHLVILFLVWDVEIVLLIP-CFQDLGV 82
Cdd:MTH00018   6 LLIFSVVLSALFSGAS---YFLGVKQPDREKVSAYECGFDPFGFPGRpFSIRFFLIGILFLIFDLEISFLFPwCVLYNQI 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 229324841  83 WSAGASPLAIFLLILSLGLYYELMEGTISW 112
Cdd:MTH00018  83 APFGFWTMVGFLFILTLGLIYEWIKGGLEW 112
ND3 MTH00136
NADH dehydrogenase subunit 3; Provisional
 8-112 3.27e-12

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177194 [Multi-domain]  Cd Length: 116  Bit Score: 58.39  E-value: 3.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841   8 LITVLS-AIPISVSLGFIS--LEEDSYDWDKSSPYECGF---VSPKIPgdFSSRFFHLVILFLVWDVEIVLLIPcfqdLG 81
Cdd:MTH00136   4 ITTILTiTIALSLILAIVSfwLPQMTPDHEKLSPYECGFdplGSARLP--FSLRFFLVAILFLLFDLEIALLLP----LP 77

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 229324841  82 VWSAGASPLAIF------LLILSLGLYYELMEGTISW 112
Cdd:MTH00136  78 WGDQLPSPLLTFfwatavLILLTLGLIYEWLQGGLEW 114
ND3 MTH00069
NADH dehydrogenase subunit 3; Provisional
 8-112 5.30e-12

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177141 [Multi-domain]  Cd Length: 114  Bit Score: 57.70  E-value: 5.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841   8 LITVLSAIPISVSLGFIS--LEEDSYDWDKSSPYECGFV---SPKIPgdFSSRFFHLVILFLVWDVEIVLLIPcfqdlgv 82
Cdd:MTH00069   3 MLMLLISTILSLILITISfwLPLNNPDSEKLSPYECGFDplgSARLP--FSIRFFLVAILFLLFDLEIALLLP------- 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 229324841  83 wSAGASPL----------AIFLLILSLGLYYELMEGTISW 112
Cdd:MTH00069  74 -TPWASQLntptntlfwsTLILILLTLGLIYEWIQGGLEW 112
ND3 MTH00113
NADH dehydrogenase subunit 3; Provisional
 5-113 6.52e-12

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177175 [Multi-domain]  Cd Length: 114  Bit Score: 57.58  E-value: 6.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841   5 LVFLITVLSAIPISVSLGFISLEEDSYDWDKSSPYECGF---VSPKIPgdFSSRFFHLVILFLVWDVEIVLLIPCfqdlg 81
Cdd:MTH00113   3 LISMLTISLALSTILTTLNFWLTQTKPDNEKLSPYECGFdplGSARLP--FSIRFFLVAILFLLFDLEIALLLPL----- 75

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 229324841  82 VWSAGASPL-------AIFLLILSLGLYYELMEGTISWT 113
Cdd:MTH00113  76 PWAINLTTPtttltwaTIILTLLTLGLIYEWLQGGLEWA 114
ND3 MTH00203
NADH dehydrogenase subunit 3; Provisional
 5-112 1.03e-11

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 214456 [Multi-domain]  Cd Length: 112  Bit Score: 56.83  E-value: 1.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841   5 LVFLITVLSAIPISVSLGFISLEEDSYDWD--KSSPYECGFV---SPKIPgdFSSRFFHLVILFLVWDVEIVLLIPCFQD 79
Cdd:MTH00203   2 NLIMLFFLIALLLSLILLFIAFWLPKVNPDgeKLSPYECGFDplgSARLP--FSLQFFLVALSFLLFDLEIALLLPLPWS 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 229324841  80 LGVWSAGASPLAIFLLILSLGLYYELMEGTISW 112
Cdd:MTH00203  80 NQLSSLSLLLAFLFLILLTLGLIYEWLQGGLEW 112
ND3 MTH00161
NADH dehydrogenase subunit 3; Provisional
 5-112 1.32e-11

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177217 [Multi-domain]  Cd Length: 113  Bit Score: 56.71  E-value: 1.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841   5 LVFLITVLSAIPISVSLGFISLEEDSYDWDKSSPYECGF---VSPKIPgdFSSRFFHLVILFLVWDVEIVLLIPC----- 76
Cdd:MTH00161   3 LIILLIILLISIILMILASLLSKKSIMDREKSSPFECGFdpkSSARLP--FSLRFFLIAIIFLIFDVEIALLLPMififk 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 229324841  77 FQDLGVWSAGASplaIFLLILSLGLYYELMEGTISW 112
Cdd:MTH00161  81 TSNMMSWLITSS---FFILILLLGLYYEWNQGALEW 113
NuoA COG0838
NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH: ...
 5-112 5.66e-11

NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 3 (chain A) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440600 [Multi-domain]  Cd Length: 117  Bit Score: 55.13  E-value: 5.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841   5 LVFLITVLSAIPISVSLGFIsLEEDSYDWDKSSPYECGFV---SPKIPgdFSSRFFHLVILFLVWDVEIVLLIP---CFQ 78
Cdd:COG0838    9 LIFLLVALGLALAMLLLSRL-LGPKRPNPEKLSPYECGIEpvgDARIR--FSVRYYLVALLFVIFDVEVVFLFPwavVFR 85

                         90       100       110
                 ....*....|....*....|....*....|....
gi 229324841  79 DLGVWsaGASPLAIFLLILSLGLYYELMEGTISW 112
Cdd:COG0838   86 ELGWF--GLIEMLVFIAILLVGLIYAWKKGALEW 117
ND3 MTH00106
NADH dehydrogenase subunit 3; Provisional
 34-113 1.79e-10

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177168 [Multi-domain]  Cd Length: 115  Bit Score: 53.79  E-value: 1.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841  34 DKSSPYECGF---VSPKIPgdFSSRFFHLVILFLVWDVEIVLLIPCfqdlgVWSAGASPLA-------IFLLILSLGLYY 103
Cdd:MTH00106  32 EKASPYECGFdpmGSARLP--FSMKFFLVAITFLLFDLEIALLLPL-----PWASQTNNLNtmltmalLLISLLALSLAY 104

                         90
                 ....*....|
gi 229324841 104 ELMEGTISWT 113
Cdd:MTH00106 105 EWTQKGLEWT 114
PRK06602 PRK06602
NADH:ubiquinone oxidoreductase subunit A; Validated
 5-113 1.18e-09

NADH:ubiquinone oxidoreductase subunit A; Validated


Pssm-ID: 180638 [Multi-domain]  Cd Length: 121  Bit Score: 51.79  E-value: 1.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841   5 LVFLItVLSAIPISVSLGFISLEEDSYDWDKSSPYECGFVSPkipGD----FSSRFFHLVILFLVWDVEIVLLIP---CF 77
Cdd:PRK06602  12 LIFLI-VAIGLGILLLVAGKLLGPRAPDREKNSPYESGFEAF---GDarmkFDVRFYLVAILFVIFDLEAAFLFPwavSF 87

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 229324841  78 QDLGV---WSAGasplaIFLLILSLGLYYELMEGTISWT 113
Cdd:PRK06602  88 REIGWlgfVEAM-----IFILVLLVGLVYLWRKGALDWE 121
PRK08489 PRK08489
NAD(P)H-quinone oxidoreductase subunit 3;
35-112 1.45e-09

NAD(P)H-quinone oxidoreductase subunit 3;


Pssm-ID: 181448 [Multi-domain]  Cd Length: 129  Bit Score: 51.59  E-value: 1.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841  35 KSSPYECGFVSPKIPGDFSSRFFHLVILFLVWDVEIVLLIPC---FQDLGVWsaGASPLAIFLLILSLGLYYELMEGTIS 111
Cdd:PRK08489  47 KLAIYECGPEPVKQPNRISSHFYIMALLFILFDVEIVFMFPWavdFKLLGLF--GLIEMLLFIVLLTIGFIYAWKKGALE 124


                 .
gi 229324841 112 W 112
Cdd:PRK08489 125 W 125
ND3 MTH00055
NADH dehydrogenase subunit 3; Provisional
 32-112 3.09e-08

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177128 [Multi-domain]  Cd Length: 118  Bit Score: 48.17  E-value: 3.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841  32 DWDKSSPYECGF---VSPKIPgdFSSRFFHLVILFLVWDVEIVLLIP-CFQDLGVWSAGASPLAIFLLILSLGLYYELME 107
Cdd:MTH00055  35 DSEKVSVYECGFdpfESSRIP--FSVRFFLVGILFLIFDLEISFLFPwCVVYNQIGLFGFWVMYLFLIILTIGLIYEWVK 112


                 ....*
gi 229324841 108 GTISW 112
Cdd:MTH00055 113 GGLEW 117
ND3 MTH00030
NADH dehydrogenase subunit 3; Provisional
 5-112 3.70e-08

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 164603 [Multi-domain]  Cd Length: 123  Bit Score: 48.01  E-value: 3.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229324841   5 LVFLITVLSAIPISVSLGFISLEEDSYDWDKSSPYECGFVS-PKIPGDFSSRFFHLVILFLVWDVEIVLLIP---CFQDL 80
Cdd:MTH00030  13 LLGVGIILLLVSISFTLGNSRIGLTKPDSEKSSIYECGFDPfGKIRTPFTIKFVLVGILFMIFDIEISFLFPwsiVFNQL 92

                         90       100       110
                 ....*....|....*....|....*....|..
gi 229324841  81 GVWSAGAspLAIFLLILSLGLYYELMEGTISW 112
Cdd:MTH00030  93 NLFSFWI--VYTFLIVLAIGLAYEWIKGGLEW 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH