|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
87-467 |
4.90e-159 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 455.14 E-value: 4.90e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 87 VKSVILVNTFLYAVCFWIQMGVLPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYG 166
Cdd:cd17331 1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 167 ILGLANSATLIFISRIPSLFLHAFQGTQMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACI 246
Cdd:cd17331 81 LLAFASSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 247 GSCVSLSLVILFIPGNTKPVQSTSAKDKSSDSVFSIKTFTHLMRSSPGAAFFLSVNLLAGLPSAIFSSMFALVVIDKFEL 326
Cdd:cd17331 161 GSLLSIVLVILLIPSNTKSKREKEAKESASPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 327 TADQNGYFLSFQGLASIVMQGVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWQLTAVLLPMTCGNCITTTVITS 406
Cdd:cd17331 241 TPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITS 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1752404508 407 VLTKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTNLGFPSLGITGAVINIVLLLVLT 467
Cdd:cd17331 321 LLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLL 381
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
97-466 |
4.68e-44 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 158.16 E-value: 4.68e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 97 LYAVCFWIQMGV------LPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILGL 170
Cdd:cd17390 1 LYLVGFLDLFGVsmilplLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 171 ANSATLIFISRIP-SLFLHAFQGTQMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWIsvSMSEQSAAAVACIGSC 249
Cdd:cd17390 81 STSLALLFLSRIPlGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHL--AETDGGFYYVALLCSA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 250 VSL---SLVILFIPgntkpvqstsakdKSSDsvfsiktfthlmrsspgaafFLSVNLLAGLPSAIFSSMFALVVIDKFEL 326
Cdd:cd17390 159 IFIlnaGLVWFLLS-------------KLWD--------------------LLLVRFLMGFSVLLFRSNFSLYLEERFDL 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 327 TADQNGYFLSFQGLASIVMQGVViGRLTKRY--SEMKLLRASAILLAASYMAMCLVQDVWQLTAVLLPMTCGNCITTTVI 404
Cdd:cd17390 206 SPKTIGYLISYSGVLGALSGFLV-GRILKLYknNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCS 284
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1752404508 405 TSVLTKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTnLGFPSLGITGAVINIVLLLVL 466
Cdd:cd17390 285 TSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQE-FSVSGPGLLGAVLALAAILLM 345
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
91-466 |
5.09e-43 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 155.04 E-value: 5.09e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 91 ILVNTFLYAVCFWIQMGVLPYL---TKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGI 167
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYvreFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 168 LGLANSATLIFISR-IPSLFLHAFQGTQMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACI 246
Cdd:cd17330 81 LGLSRNLWLLFLARfLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 247 GSCVSLSLVILFIPgntkpvqstsakdkssdSVFSIktfthlmrsspgaaffLSVNLLAGLPSAIFSSMFALVVIDKFEL 326
Cdd:cd17330 161 LALLNLVLVLFFLP-----------------PLRRL----------------LLVYFLIALAFAGLESVFSLFLKDRFGF 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 327 TADQNGYFLSFQGLASIVMQGVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWQLTAVLLPMTCGNCITTTVITS 406
Cdd:cd17330 208 SPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSA 287
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 407 VLTKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTNLGFPSLGITGAVINIVLLLVL 466
Cdd:cd17330 288 LLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLL 347
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
90-435 |
1.19e-32 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 127.01 E-value: 1.19e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 90 VILVNTFLYAVCFWIQMGVLPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILG 169
Cdd:COG2814 14 ALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 170 LANSATLIFISRIPSLFLHA--FQGTQMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACIG 247
Cdd:COG2814 94 LAPSLWLLLAARFLQGLGAGalFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 248 SCVSLSLVILFIPGNTKPVQSTSAkdkssdsvfsiKTFTHLMRSSPGAAFFLsVNLLAGLPSAIFSSMFALVVIDKFELT 327
Cdd:COG2814 174 ALLALLLLLRLLPESRPAARARLR-----------GSLRELLRRPRLLLLLL-LAFLLGFGFFALFTYLPLYLQEVLGLS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 328 ADQNGYFLSFQGLASIVMQgVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWQLTAVLLPMTCGNCITTTVITSV 407
Cdd:COG2814 242 ASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQAL 320
|
330 340
....*....|....*....|....*...
gi 1752404508 408 LTKAVPASESGTILGLTHAGTSLLGTLA 435
Cdd:COG2814 321 VAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
91-466 |
6.36e-32 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 125.38 E-value: 6.36e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 91 ILVNTFLYAVCFWIQMGVLPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILGL 170
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 171 ANSATLIFISRIPSLFLHAFQGT--QMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACIGS 248
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPaaMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 249 CVSLSLVILFIPGNTKPVQSTSAKDKSSDSVFsiktftHLMRSSPGAAFFLSVNLLAGLPSAIFSSMFALVVIDKFELTA 328
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGL------RLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 329 DQNGYFLSFQGLASIVMQgVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWQLTAVLLPMTCGNCITTTVITSVL 408
Cdd:cd17325 235 AQIGLLFGAQGLASALSQ-PPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALL 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1752404508 409 TKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTNLGFPSLGITGAVINIVLLLVL 466
Cdd:cd17325 314 ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLF 371
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
90-466 |
4.99e-30 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 120.43 E-value: 4.99e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 90 VILVNTFLYAVCFWIQMGVLPYLTKKF--DMDMV--TFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIY 165
Cdd:cd17388 3 FILVTVLLDAMGIGLIMPVLPTLLREFvgDSADAatHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 166 GILGLANSATLIFISRIPSLFLHAFQGTQM-VISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVsMSEQSAAAVA 244
Cdd:cd17388 83 LLMAFAPTLWWLYLGRIIAGITGATGAVAAaYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-ISPRAPFLVA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 245 CIGSCVSLSLVILFIPGNTKPVQSTSAKDKSSDSVFSIKTFTHLmrssPGAAFFLSVNLLAGLPSAIFSSMFALVVIDKF 324
Cdd:cd17388 162 AGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGF----PGLLGLLAVFFLIQLIGQVPATTWVLFTEDRF 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 325 ELTADQNGYFLSFQGLASIVMQGVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWQLTAVLLPMTCGNcITTTVI 404
Cdd:cd17388 238 DWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGG-IAGPAL 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1752404508 405 TSVLTKAVPASESGTILGlthAGTSLLGtLAPIIGAVLLTNL-GFPSLGITGAVINIVLLLVL 466
Cdd:cd17388 317 QGLLSRQVPENEQGELQG---VLTSLTS-LTSIIGPLLFTGIfAASPATWPGLAWIIGAALYL 375
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
108-468 |
2.44e-23 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 101.11 E-value: 2.44e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 108 VLPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALglayLSAAAIYGILG----LANSATLIFISRip 183
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVL----LPGLLLFGIGGllcgLSDSFALLLAGR-- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 184 slflhAFQG---------TQMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWIsVSMSEQSAAAVACIGSCVSLSL 254
Cdd:cd17474 95 -----ALQGigaaglgplALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLLAALIPVAFLA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 255 VILFIPGNTKPVQSTSAKDKSSdsvfSIKTFTHlmrsspgaAFFLSVNLLAGLPSAIFSSMFA---LVVIDKFELTADQN 331
Cdd:cd17474 169 ILFLLPEPKEKAKSSSATKLRD----LKKALRG--------RGLLTFLVSAFLYFFLYFAFLTylpFLLELLYGISPIII 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 332 GYFLSFQGLASIVMQGVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWQLTAVLLPMTCGNCITTTVITSVLTKA 411
Cdd:cd17474 237 GLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTEL 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1752404508 412 VPASESGTILGLTHAGTSLLGTLAPIIGAVLLTNLGFPSLGITGAVINIVLLLVLTK 468
Cdd:cd17474 317 APEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
91-466 |
2.45e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 101.35 E-value: 2.45e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 91 ILVNTFLYAVCFWIQMGVLPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILGL 170
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 171 ANSATLIFISRIPSLFLHAFQGTQM--VISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVAcIGS 248
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVlaLIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFL-IAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 249 CVSLSLVILFIPGNTKPVQSTSAKDKSSDSVFSIKTFTHLMRSsPGAAFFLSVNLLAGLPSAIFSSMFALVVIDKFELTA 328
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKN-PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 329 DQNGYFLSFQGLASIVMQGVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWQLTAVLLPMTCGNCITTTVITSVL 408
Cdd:cd06174 239 AVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1752404508 409 TKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLL-TNLGFPSLGITGAVINIVLLLVL 466
Cdd:cd06174 319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
91-436 |
1.35e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 95.56 E-value: 1.35e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 91 ILVNTFLYAVCFWIQMGVLP-YLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILG 169
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 170 LANSATLIFISRIPSLFLHA--FQGTQMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACIG 247
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGalFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 248 SCVSLSLVILFIPgntkPVQSTSAKDKSSDSVFSIKTFTHLMRSSPGAAFFLSVNLLAGLPSAIFssmFALVVIDKFELT 327
Cdd:pfam07690 161 SLLAAVLLLLPRP----PPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLT---YLPLYQEVLGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 328 ADQNGYFLSFQGLASIVMQgVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWQLTAVLLPMTC---GNCITTTVI 404
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGR-LLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLlgfGFGLVFPAL 312
|
330 340 350
....*....|....*....|....*....|..
gi 1752404508 405 TSVLTKAVPASESGTILGLTHAGTSLLGTLAP 436
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
90-466 |
3.72e-21 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 94.60 E-value: 3.72e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 90 VILVNTFLYAVCFWIQMGVLP-YLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGIL 168
Cdd:cd17329 3 VLLIGSFLNRLGFFMVWPFMAiYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 169 GLANSATLIFISRIPSLFLHAFQGTQM--VISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACI 246
Cdd:cd17329 83 GFAHSPWLFAIALVLTGFGGGLFEPASeaMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 247 gsCVSLSLVILFIPGNTKPVQSTSAKDKSSDSVFSIKTFTHLMRsspgaafFLSVNLLAGLPSAIFSSMFALVVIDKFEL 326
Cdd:cd17329 163 --FLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLL-------FLLASFLISLIYFQLESTLPVYVVEILGL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 327 TADQNGYFLSFQGLASIVMQgVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWQLTAVLLPMTCGNCITTTVITS 406
Cdd:cd17329 234 GESLLGLLLALNALLIVLLQ-FPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQT 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 407 VLTKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTNLGFPSLGITGAVINIVLLLVL 466
Cdd:cd17329 313 LVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALL 372
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
95-466 |
1.92e-19 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 89.60 E-value: 1.92e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 95 TFLYAVCFWIQMGVLPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAY-LSAAAIYGILGLANS 173
Cdd:cd06173 8 QLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADlLRALLAAVLALLALL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 174 ATLIFISRIPSLFLHAFQGT------QMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACIG 247
Cdd:cd06173 88 GSLSLWLLLVLAFLLGIASAffgparQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALS 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 248 SCVSLsLVILFIPGNTKPVQSTSAKDKSSDSVFSIKTFthlmRSSPGAAFFLSVNLLAGLPSAIFSSMFALVVIDKFELT 327
Cdd:cd06173 168 FLLSA-LLLLFIRRPPPAAPGESSSLLLRDLREGLRYL----RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 328 ADQNGYFLSFQGLASIVMqGVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWQLTAVLLPMTCGNCITTTVITSV 407
Cdd:cd06173 243 AAGYGLLLAAFGVGALLG-ALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTL 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1752404508 408 LTKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTNLGFPSLGITGAVINIVLLLVL 466
Cdd:cd06173 322 LQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
91-465 |
5.98e-17 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 82.26 E-value: 5.98e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 91 ILVNTFLYAVCFWIQMGVLPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILGL 170
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 171 ANSATLIFISRIpslfLHAF------QGTQMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWIsvsMSEQSAAAVA 244
Cdd:cd17489 81 ATSVALLLVLRL----IHGIgwgaftTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFL---YQHLGFAVLF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 245 CIGSCVSL--SLVILFIPGNTKPVQSTSAKDKSSDSVFSIKTFThlmrsSPGAAFFLSvnllaglpSAIFSSMFALVVID 322
Cdd:cd17489 154 IVAAVLALlaLLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVL-----PPALILFLA--------SIAYGAISTFLPLY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 323 KFELTADQNGYFLSFQGLASIVMqGVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWQLTAVLLPMTCGNCITTT 402
Cdd:cd17489 221 AAERGISNAGLFFTVYAIALLLS-RPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFP 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1752404508 403 VITSVLTKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTNLGFPSLGITGAVINIVLLLV 465
Cdd:cd17489 300 ALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
89-467 |
8.50e-17 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 81.83 E-value: 8.50e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 89 SVILVNTFLYAVcfwiqMGVLPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGIL 168
Cdd:cd17324 7 AAFAIGTTEYVI-----QGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 169 GLANSATLIFISRIPSLFLHA--FQGTQMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACI 246
Cdd:cd17324 82 ALAPSFALLLLARALAGLAHGgfWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 247 GSCVSLSLVILFIPgntkpvqstSAKDKSSDSVFSIKTFTHLMRSSPGAAFFLSVNLLAGLPSAIFSSMFALVVIDKFEL 326
Cdd:cd17324 162 LALLAALLLWRLLP---------SLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 327 TADQNGYFLSFqGLASIVMqGVVIGRLTKRYSeMKLLRASAILLAASYMAMCLV-QDVWQLTAVLLPMTCGNCITTTVIT 405
Cdd:cd17324 233 SSAIIGLLLLF-GVAGVVG-SPLAGRLADRGG-RRALLIALLLLAAALLLLTLLgPSPLLLLVGLVLWGLGFFAAHSALQ 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1752404508 406 SVLTKAVPASeSGTILGLTHAGTSLLGTLAPIIGAVLLTNLGFPSLGITGAVINIVLLLVLT 467
Cdd:cd17324 310 TRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
90-468 |
1.87e-15 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 77.60 E-value: 1.87e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 90 VILVNTFLYAVCFWIQMGV---LPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYG 166
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLsvaAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 167 ILGLANSATLIFISRIpslFLHAFQGTQM-----VISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAA 241
Cdd:COG2271 91 LFGFATSFWQLLLLRF---LLGLGEAGFFpaalkLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 242 AVACIGSCVSLSLVILFIpgntkpvqstsakdkssdsvfsiktfthlmrsspGAAFFLSVNLLAGlpsaiFSSMFALVVI 321
Cdd:COG2271 168 LILGLPGLLLALLRFWLL----------------------------------ALAYFLVYFALYG-----FLTWLPTYLV 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 322 DKFELTADQNGYFLSFQGLASIVMqGVVIGRLTKRY--SEMKLLRASAILLAASYMAMCLVQDVWQLTAVLLPMTCGNCI 399
Cdd:COG2271 209 EVRGLSLAQAGLLLSLPFLAGIVG-SLLGGWLSDRLgrRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGG 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1752404508 400 TTTVITSVLTKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTNLGFPS---LGITGAVINIVLLLVLTK 468
Cdd:COG2271 288 AFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAaflLLAALALLAALLALLLLR 359
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
136-466 |
1.06e-14 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 75.30 E-value: 1.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 136 VGGPIYGRFGDVYGGRAALglayLSAAAIYGILGLA----NSATLIFISRIpslFLHAFQGTQMV-----ISDLSDEAGR 206
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLL----IAGLLLYGIGGVAglflDSLYALLASRA---LLGIGVAGIMTlatalIGDYFEGEER 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 207 TEALGRVSMCYSIGIVVGPLIGGWISvSMSEQSAAAVACIGSCVsLSLVILFIPGNTKPVQSTSAKDKSSDSVFSIKTFT 286
Cdd:cd17473 123 AKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYLLALPV-LILVLLFLPEPARKSKSAASPGAATAAALPWKRVL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 287 HLMrsspGAAFFLSVnLLAGLPSAIfssmfALVVIDKFELTADQNGYFLSFQGLASIVMqGVVIGRLTKRYSEMKLLRAS 366
Cdd:cd17473 201 PIY----FLAFLAML-LFYVIPIQL-----PFLLQERGGGSAALIGLALAIASLAGAIG-ALLFGRLKRRLGKRRLLAIG 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 367 AILLAASYMAMCLVQDVWQLTAVLLPMTCGNCITTTVITSVLTKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTNL 446
Cdd:cd17473 270 FALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLT 349
|
330 340
....*....|....*....|....*
gi 1752404508 447 GFPS-----LGITGAVINIVLLLVL 466
Cdd:cd17473 350 GGLSgafliLGVLALVLAIVLLLLR 374
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
90-467 |
2.73e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 74.15 E-value: 2.73e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 90 VILVNTFLYAVCFWIQMG---VLPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYG 166
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLwsvLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 167 ILGLANSATLIFISRIPSLFLHA--FQGTQMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVA 244
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGgsFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 245 CIGSCVSLSLVILFIPgNTKPVQSTSAKDKSSDSVFSIKTF-THLMrsspgaAFFLSVNLLAGLPsaiFSSMFALVVIDK 323
Cdd:COG2223 166 GILLLVVAVLAWLFLR-DPPAGAAAAAKASLRDQLEALRDPrFWLL------SLLYFGTFGSFIG---FSSWLPPYLVDQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 324 FELTADQNGYFLSFQGLASIVMqGVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQ-DVWQLTAVLLPMTCGNCITTT 402
Cdd:COG2223 236 FGLSAATAGLLAALFALLGALG-RPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNG 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1752404508 403 VITSVLTKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTNLGFPSLGITGAVINIVLLLVLT 467
Cdd:COG2223 315 AVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLT 379
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
91-466 |
6.88e-14 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 72.59 E-value: 6.88e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 91 ILVNTFLYAVCFWIQMGVLPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILGL 170
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 171 ANSATLIFISRipsLFLHAFQGTQMVISD-----LSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVsmseQSAAAVAC 245
Cdd:cd17477 81 TDSPWVWFLLR---FVMGIGLAGLFVVSEswlnaLATNENRGRVLGLYSTVLGLGFALGPLLLALVGT----AGALPFLI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 246 IGSCVSLSLVILFIPGNTKPVQSTSAKdkssdsvfsiKTFTHLMRSSPGAaffLSVNLLAGLPSAIFSSMFALVVIDKfE 325
Cdd:cd17477 154 AAVLLLLALVPLLLTRRAAPEIEEAES----------ISLRRLLRIAPLA---LLGAFVAGFLEGAFYSLLPLYGLRL-G 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 326 LTADQNGYFLSFQGLASIVMQgVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWQLTAVLLPMTcGNCITT--TV 403
Cdd:cd17477 220 LSVAQAALLLAAFVLGGLLLQ-WPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLW-GGAAGPlyTL 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1752404508 404 ITSVLTKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTNLGFPSLGITGAVINIVLLLVL 466
Cdd:cd17477 298 ALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
197-464 |
1.04e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 72.63 E-value: 1.04e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 197 ISDLS-DEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAA---AVACIGSCVSLSLVILFIPGNTKPVQSTSAK 272
Cdd:COG2211 135 GAELTpDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALgyrLTALIFAVLGLLAFLLTFFGTKERPVPEEEK 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 273 DKSSDSVFSIKTFTHLMRsspgaafFLSVNLLAGLPSAIFSSMFALVVIDKFELTADQNGYFLSFQGLASIVMQgVVIGR 352
Cdd:COG2211 215 VSLKESLKALLKNRPFLL-------LLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGA-PLWPR 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 353 LTKRYSEMKLLRASAILLAASYMAMCLVQ--DVWQLTAVLLPMTCGNCITTTVITSVLTKAVPASE-------SGTILGL 423
Cdd:COG2211 287 LAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGI 366
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1752404508 424 THAGTSLLGTLAPIIGAVLLTNLGF-PSLGITGAVINIVLLL 464
Cdd:COG2211 367 FTFAIKLGQALAGALAGLLLALFGYvAGAAQSPSALTGIRLL 408
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
124-469 |
2.80e-13 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 71.15 E-value: 2.80e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 124 GYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILGLANSATLIFISRIPSLFLHAFQGTQM-VISDLSD 202
Cdd:cd17389 67 GLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTaIVADVTS 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 203 EAGRTEALGRVSMCYSIGIVVGPLIGGWISV------SMSEQSAAAVACIGSCVSLSLVILFIPgNTKPVQstsakdkss 276
Cdd:cd17389 147 PKKRSKGMALIGVAFSLGFIIGPMIGAYFASftrslgEVFFSMPALFALVLALADLLFIFFFLP-ETLPSN--------- 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 277 dsvfsiktfthlMRSSpGAAFFLSVNLLAGLPsaifssmFALVVI--DKFELTADQNGYFLSFQGLASIVMQGVVIGRLt 354
Cdd:cd17389 217 ------------LRRL-GLVYFLYLFLFSGLE-------FTLTFLthQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRI- 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 355 KRYSEMKLLRASAILLAASYMAMCLVQDVWQLTAVLLPMTCGNCITTTVITSVLTKAVPASESGTILGLTHAGTSLLGTL 434
Cdd:cd17389 276 KPGKEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARAL 355
|
330 340 350
....*....|....*....|....*....|....*
gi 1752404508 435 APIIGAVLLTNLGFPSLGITGAVINIVLLLVLTKY 469
Cdd:cd17389 356 GPIVACTVYWLAGSEACYTIGALLFLLPLLLLARL 390
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
134-447 |
3.99e-13 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 70.43 E-value: 3.99e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 134 MLVGGPIYGRFGDVYGGRA---------ALGLAYLSAAAIYGILGLANSATLIFISRIPSLFLhaFQGTQMVISDLSDEA 204
Cdd:TIGR00900 47 YVVLSPIAGALADRYDRKKvmigadlirAVLVAVLPFVALLGGLNIWQVYVLAGILAIAQAFF--TPAYQAMLPDLVPEE 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 205 GRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACIGSCVSLSLVILF-IPGNTKPvqstSAKDKSSDSVFSIK 283
Cdd:TIGR00900 125 QLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWAIWVDAVGFAISALLIVSVrIPELAAS----EIQALSNAVLRDTR 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 284 TFTHLMRSSPGAAFFLSVNLLAGLPSA-IFSSMFALVVIDKFELTADQNGYFLSFQGLASIvMQGVVIGRLTKRYSEMKL 362
Cdd:TIGR00900 201 EGIKFVLKNPLLRTLLLLALLFNLVFApAIVALFPYVQSKYLGRGSTHYGWVLAAFGLGAL-LGALLLGLLGRYFKRMAL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 363 LRASAILLAASYMAMCLVQDVWQLTAVL-LPMTCGNCITTTVITSVLTKAVPASESGTILGLTHAGTSLLGTLAPIIGAV 441
Cdd:TIGR00900 280 MTGAIFVIGLAILVVGLTPPNFPLFLVLwFAIGVGYGPINVPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILAGP 359
|
....*.
gi 1752404508 442 LLTNLG 447
Cdd:TIGR00900 360 LADHLG 365
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
126-466 |
3.20e-12 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 67.99 E-value: 3.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 126 LQTFFSGiMLVGGPIYGRFGDVYGGRAAL--GLAYLSAAAIygILGLANSATLIFISRipslFLHAFQG------TQMVI 197
Cdd:cd17320 40 LSAYLLG-FALGQLLYGPLSDRFGRRPVLlaGLLLFILASL--LCALASSIEQLLIAR----FLQGLGAaagsvvARAIV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 198 SDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACIGSCVSLSLVILFIPGnTKPVQSTSAKDKSsd 277
Cdd:cd17320 113 RDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPE-TLPEEKRKPLLSS-- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 278 svfSIKTFTHLMRsSPGAAFFLSVNLLAGLPSAIFSSMFALVVIDKFELTADQNGYFLSFQGLASIVMqGVVIGRLTKRY 357
Cdd:cd17320 190 ---LLRAYKRVLK-NRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILG-SLLNGRLVRRF 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 358 SEMKLLRASAILLAASYMAMCLVQ-----DVWQLTAVLLPMTCGNCITTTVITSVLTKAVPasesgtilglTHAGT--SL 430
Cdd:cd17320 265 GPRRLLRLGLLLLLAAALVLLLAAllgglSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP----------HVAGTasAL 334
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1752404508 431 LGTLAPIIGAV------LLTNLGFPSLGITGAVINIVLLLVL 466
Cdd:cd17320 335 LGFLQFLIGALagalvgLLPNGTALPMGLLILVLGLLALLLL 376
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
80-384 |
7.69e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 66.80 E-value: 7.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 80 TNVNMNVVKSVILVNTFLYAVCFWIQMGVLPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYL 159
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 160 SAAAIYGILGLANSATLIFISRIPSLFLHAFQGTQM--VISDLSDEAGRTeALGRVSMCYSIGIVVGPLIGGW-ISVSMS 236
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAAnpYVAALGPETAAS-RLNLLHAFFSLGALLGPLLGGLlILLGLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 237 EQSAAAVACIGSCVSLSLVILF---IPGNTKPVQSTSAKDKSSDSVFSIKTFTHLmrsspGAAFFLSVnllagLPSAIFS 313
Cdd:COG0738 161 LSWHLPYLILAVLLLLLALLFLrskLPEIEEEEEEAAGSAASLKSLLKNPRLLLG-----GLAIFLYV-----GAEGAIG 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1752404508 314 SMFALVVIDKFELTADQNGYFLSFQGLASIVMQgVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVW 384
Cdd:COG0738 231 DWLPLYLKDVLGLSEATAALGLSLFWGGMTIGR-FLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPW 300
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
109-467 |
9.69e-12 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 66.25 E-value: 9.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 109 LPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILGLANSATLIFISRipslFLH 188
Cdd:TIGR00710 28 FPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLR----FVQ 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 189 AFQG------TQMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACIGSCVSLSLVILFIPgn 262
Cdd:TIGR00710 104 AFGAsagsviSQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILP-- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 263 tkpvqSTSAKDKSSDSVFSIKTFTHLMRSspgaaffLSVNLLAGLPSAIFSSMFA------LVVIDKFELTADQNGYFLS 336
Cdd:TIGR00710 182 -----ETLPYEARIQISTYFETFLLLLKS-------KMFWGYALIYGASFGGFFAffsgapFVYIDIMGVSPSVFGLLFA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 337 FQGLASIVMqGVVIGRLTKRYSEMKLLRASAILLAAS--YMAMCLVQDVWQLTAVLLPMTCGNCITTTVITSVLTKAVpa 414
Cdd:TIGR00710 250 LNIIAMIFG-GFLNGRFIKKWGAKSLLRMGLILFAVSavLLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMAYAL-- 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1752404508 415 SESGTILGlthAGTSLLGTLAPIIGAVLLTNLGfpSLGITGAVINIVLLLVLT 467
Cdd:TIGR00710 327 EDFPHVAG---TASALFGTLRLVLGAIVGYLVS--LIHGNTAWPMSLSCLVLA 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
90-259 |
2.20e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 65.29 E-value: 2.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 90 VILVNTFLYAVCFWIQMGVLP-YLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGIL 168
Cdd:cd17325 203 ALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 169 GLANSATLIFISRIPSLFLHAFQGTQM--VISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACI 246
Cdd:cd17325 283 PLATSFWLLLLLLALLGLGLGLVFPATlaLLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAA 362
|
170
....*....|...
gi 1752404508 247 GSCVSLSLVILFI 259
Cdd:cd17325 363 LLLLAAVLFLLLR 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
298-466 |
2.66e-10 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 61.67 E-value: 2.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 298 FLSVNLLAGLPSAIFSSMFALVVIDKFELTADQNGYFLSFQGLASIVMQgVVIGRLTKRYSEMKLLRASAILLAASYMAM 377
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ-PLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 378 CLVQDVWQLTAVLLPMTCGNCITTTVITSVLTKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTNLGFPSLGITGAV 457
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
....*....
gi 1752404508 458 INIVLLLVL 466
Cdd:pfam07690 160 LSLLAAVLL 168
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
108-445 |
3.77e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 61.44 E-value: 3.77e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 108 VLPYLTKKFDMDMVTFGYLQTFFsgiMLVGG---PIYGRFGDVYGGRAALGLAYLSAAAIYGILGLANSATLIFISRips 184
Cdd:cd17504 18 ALPTIQREFGTSAAAVSWVLTAY---LLVGAvstPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGR--- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 185 lflhAFQGTQM--------VISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACIGSCVSLSLVI 256
Cdd:cd17504 92 ----ALQGIGGavfplafaLVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 257 LFipgntkpvqstsakdkssdsvfSIKTFTHlmrssPGAAFFLSVNLLAGLpsAIFSSMFALVVIDK------FELTADQ 330
Cdd:cd17504 168 LI----------------------DLRLLRR-----RNVLLANITALLAGF--GMFMVFQLLPQLLQlptptgFGLGITE 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 331 NGYFLSFQGLASIVMqGVVIGRLTKRYSEMKLLRASAILLAASYMAMCLV-QDVWQLTAVLLPMTCGNCITTTVITSVLT 409
Cdd:cd17504 219 AGLLLLPGALVMLIA-GPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLhSSLWALVVALLLIGIGLGLAFASLPNIVV 297
|
330 340 350
....*....|....*....|....*....|....*.
gi 1752404508 410 KAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTN 445
Cdd:cd17504 298 ESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTT 333
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
91-456 |
5.90e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 60.65 E-value: 5.90e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 91 ILVNTFLYAVCFWIQMGVLPYLTKKFDMDMVTfgyLQTFFSGIMLVGG---PIYGRFGDVYGGRaalgLAYLSAAAIYGI 167
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQ---LQWVVNAYLLAFAallLLAGRLGDRFGRK----RVFLIGLALFGL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 168 ----LGLANSATLIFISRipslflhAFQG---------TQMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVS 234
Cdd:cd17321 74 asllCALAPSLAFLIAAR-------ALQGigaaaimpaSLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLEL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 235 MSEQSAAAVacigsCVSLSLVILFIpgntkpvqstsakdkssdsvfsiktfthlmrsspgAAFFLSVNLLAGLPSAIFSS 314
Cdd:cd17321 147 FGWRWIFLI-----NVPIGLVALLL-----------------------------------ARTFSGAVLAAFLLGAALGG 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 315 MF---ALVVIDKFELTADQNGYFLSFQGLASIVMqGVVIGRLTKRYSEMKLLRASAILLAASYMAMCLV---QDVWQLTA 388
Cdd:cd17321 187 LLfllPLYLQGVLGYSPLQAGLALLPLALAMLVA-APLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLgadSSVWLLLP 265
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1752404508 389 VLLPMTCGNCITTTVITSVLTKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTNLGFPSLGITGA 456
Cdd:cd17321 266 GLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLGDSGV 333
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
296-469 |
3.14e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 58.45 E-value: 3.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 296 AFFLSVNLLAGLPSAIFSSMFALVVIDkFELTADQNGYFLSFQGLASIVMQgVVIGRLTKRYSEMKLLRASAILLAASYM 375
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 376 AMCLVQDVWQLTAVLLPMTCGNCITTTVITSVLTKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTNLGFPSLGITG 455
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170
|
170
....*....|....
gi 1752404508 456 AVINIVLLLVLTKY 469
Cdd:COG2814 171 AVLALLALLLLLRL 184
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
109-466 |
7.12e-09 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 57.59 E-value: 7.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 109 LPYLT---KKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYG-GRAALGLAYLSAAAIYGILGLAnsaTLIFISRIPS 184
Cdd:cd17335 17 LPFLSvylKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFV---AQIFWLLLLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 185 LFLHA-FQGTQMVISD---LSDEAGRTEALGRVSMCYSIGIVVG-PLIGGWISVSMSEQSAAA---VACIGSCVSLSLVI 256
Cdd:cd17335 94 VILGAfFSAPVVPLVDsitLQYLGEERERYGKQRLWGSIGFGIAaLLVGILIDRSSTYKNYTIafyVFAVLMLLALLLAL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 257 LFIPGNTKPVQSTSAKDkssdsvfsiktFTHLMRSSPGAAFFLSVNLLAGLPSAIFSSMFALvvIDKFELTADQNGYFLS 336
Cdd:cd17335 174 KFPFRPKHPEPNENTGG-----------LLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWH--LQDLGGSKTLIGLLWT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 337 FQGLASIVMQgVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWqltaVLLPMTCGNCITTTVI----TSVLTKAV 412
Cdd:cd17335 241 VGVVSEIPFF-FFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPW----LVLPIELLHGLTFALVwaaaVSYASAAA 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1752404508 413 PASESGTILGLTHAGTSLLGT-LAPIIGAVLLTNLGFPSLGITGAVINIVLLLVL 466
Cdd:cd17335 316 PPGLRATAQGLLQGLYFGLGGgLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAF 370
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
109-445 |
9.77e-09 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 57.20 E-value: 9.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 109 LPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAAlglaYLSAAAIYGI----LGLANSATLIFISRIps 184
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRL----FLTALALFTLgsllCGLAPNLASLIIFRI-- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 185 lflhaFQG---------TQMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVA---CIGSCVSL 252
Cdd:cd17503 93 -----LQGfgggvliplAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINlpiGILALLLA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 253 SLVILfipgntkpvqstsakdkssdSVFSIKTFThlmrsspgaaFFLSVNLLAGLpsAIFSSMF--ALVVIDKFELTADQ 330
Cdd:cd17503 168 PLLDL--------------------RLFKDRNFT----------LGLLLSFLLGL--GLFGAMFllPLYLQNVLGYSAFE 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 331 NGYFLSFQGLASIVMQgVVIGRLTKRYSEMKLLRASAILLAASYMAMCLV---QDVWQLTAVLLPMTCGNCITTTVITSV 407
Cdd:cd17503 216 SGLVLAPGGLASAILS-PLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLtpdTSLWLIILPLFIRGLGMGLVFMPLNTL 294
|
330 340 350
....*....|....*....|....*....|....*...
gi 1752404508 408 LTKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTN 445
Cdd:cd17503 295 ALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTN 332
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
139-448 |
4.71e-08 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 54.96 E-value: 4.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 139 PIYGRFGDVYGGRAALGLAYLSAAAIYGILGLANSATLIFISRipsLFLHAFQG-----TQMVISDL-SDEAGRteALGR 212
Cdd:cd17391 54 PIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILR---LLQGVFSGyvpnaTALIASQTpKEKSGW--ALGT 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 213 VSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACIGSCVSLSLVILFIPGNTKPVQSTsaKDKSSDSVFSIKTFTHLMRSs 292
Cdd:cd17391 129 LSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKK--KMVSTKEVWNSVPNPSLLIS- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 293 pgaAFFLSVNLLAGLPSaiFSSMFALVVIdkfELTADQN------GYFLSFQGLASIVmQGVVIGRLTKRYSEMKLLRAS 366
Cdd:cd17391 206 ---LFVTTFIIQLANQS--IEPILTLYIR---QLMGDASnlafisGLVFSATGVSSLL-SAPRLGKLGDRIGHHRILLGA 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 367 AILLAASYMAMCLVQDVWQLTAVLLPMTCGNCITTTVITSVLTKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTNL 446
Cdd:cd17391 277 LLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHF 356
|
..
gi 1752404508 447 GF 448
Cdd:cd17391 357 GY 358
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
90-321 |
5.79e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 54.05 E-value: 5.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 90 VILVNTFLYAVCFWIQMGVLPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILG 169
Cdd:COG0477 18 ALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 170 LANSATLIFISRipslflhAFQG---------TQMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSA 240
Cdd:COG0477 98 LAPSPELLIAAR-------ALQGigagglmpgALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 241 AAVACIGSCVSLSLVILFIPGNTKPVQSTSAKDKSSDSVFSIKTFTHLMRSSPGAAFFLSVNLLAGLPSAIFSSMFALVV 320
Cdd:COG0477 171 FLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLAL 250
|
.
gi 1752404508 321 I 321
Cdd:COG0477 251 L 251
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
128-258 |
3.11e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 52.21 E-value: 3.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 128 TFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILGLANSATLIFISripSLFLHAFQGT-----QMVISDLSD 202
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLA---AVLYGLGFGLlfpalQALAVDLVP 310
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1752404508 203 EAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACIGSCVSLSLVILF 258
Cdd:cd17489 311 PHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
135-260 |
3.63e-07 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 49.19 E-value: 3.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 135 LVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILGLANSATLIFISRIPSLFLHAFQGT--QMVISDLSDEAGRTEALGR 212
Cdd:TIGR00880 12 LIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVagAALIADIYPPEERGVALGL 91
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1752404508 213 VSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACIGSCVSLSLVILFIP 260
Cdd:TIGR00880 92 MSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
95-259 |
5.21e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 51.81 E-value: 5.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 95 TFLYAVCFWIQMGVL----PYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILGL 170
Cdd:COG2223 211 SLLYFGTFGSFIGFSswlpPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLAL 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 171 ANSATLIFIsrIPSLFLHAFQG-----TQMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWIsVSMSEQSAAAVAC 245
Cdd:COG2223 291 ALGSLWLFL--VLFLLLGLALGggngaVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL-LDATGSYTAAFLV 367
|
170
....*....|....
gi 1752404508 246 IGSCVSLSLVILFI 259
Cdd:COG2223 368 FAVLALVALVLTLL 381
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
85-260 |
6.09e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 51.42 E-value: 6.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 85 NVVKSVILVNTFLYAVCFWIQMGVLP-YLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAA 163
Cdd:cd17473 196 WKRVLPIYFLAFLAMLLFYVIPIQLPfLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMAL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 164 IYGILGLANSATLIfisrIPSLFLHAFqGTQMV-------ISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMS 236
Cdd:cd17473 276 GFLLLALASGLWVV----LLGAILAGL-GFGLLlptlnswAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTG 350
|
170 180
....*....|....*....|....
gi 1752404508 237 EQSAAAVACIGSCVSLSLVILFIP 260
Cdd:cd17473 351 GLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
338-466 |
1.02e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 50.67 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 338 QGLASIVMQGVvIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWQLTAVLLPMTCGNCITTTVITSVLTKAVPASES 417
Cdd:cd17489 40 FTLAALLARPF-AGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRR 118
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1752404508 418 GTILGLTHAGTSLLGTLAPIIGAVLLTNLGFPSLGITGAVINIVLLLVL 466
Cdd:cd17489 119 GEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLV 167
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
95-260 |
1.16e-06 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 50.65 E-value: 1.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 95 TFLYA-VCFWIQMG------VLPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRaalgLAYLSAAAIYGI 167
Cdd:cd17323 1 VFIISfLTFVVTFGssiyspALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRR----PVYLVSLFIFVI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 168 ----LGLANSATLIFISRipslFLHAFQG------TQMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSE 237
Cdd:cd17323 77 fqigCALAPNIAMLIILR----FLQGFFGssplaiGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGW 152
|
170 180
....*....|....*....|...
gi 1752404508 238 QSAAAVACIGSCVSLSLVILFIP 260
Cdd:cd17323 153 RWIFWFLAIISGFCLILIFLFLP 175
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
298-466 |
1.67e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 49.85 E-value: 1.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 298 FLSVNLLAGLPSAIFSSMFALVVIDKFELTADQNGYFLSFQGLASIVMqGVVIGRLT-KRYSEMKLLRASAILLAASYMA 376
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVV-SQWLGRLSdRGGDRKPLILLALLAGALGYLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 377 MCLVQDVWQLTAVLLP-MTCGNCITTTVITSV--LTKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTNLGFPSL-G 452
Cdd:cd17471 80 FAFLRNYWVLLLVGVVlLSLGAAAFPQLFALAreYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLfL 159
|
170
....*....|....
gi 1752404508 453 ITGAVINIVLLLVL 466
Cdd:cd17471 160 LAALLYLVVALLVL 173
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
109-467 |
2.12e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 49.49 E-value: 2.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 109 LPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILGLANSATLIFISRIpslFLH 188
Cdd:cd17319 26 APTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRF---LLG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 189 AFQGTQM-----VISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACIgscVSLSLVILFIpgnt 263
Cdd:cd17319 103 VAEAGFFpgaikALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGL---LGLLLAVLWW---- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 264 kpvqstsakdkssdsvFSIKTFTHLMrsspgAAFFLSVNLLAGlpsaiFSSMFALVVIDKFELTADQNGYFLSFQGLASI 343
Cdd:cd17319 176 ----------------FYLRQVWGLA-----LGYFGINYALYG-----LLTWLPTYLKQARGFSLKQVGLLAAIPFLAGA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 344 VMqGVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWQLTAVLLPMTCGNC---ITTTVITSVLTKAVPASESGTI 420
Cdd:cd17319 230 IG-MILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFgigAASPVFWSLPADLLPGEAAATA 308
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1752404508 421 LGLTHAGTSLLGTLAP-IIGAVLLTNLGF-PSLGITGAVINIVLLLVLT 467
Cdd:cd17319 309 GGLINSGGNLGGFVAPlLIGYLVDATGSYtAAFLFLAAVALLAALLVLL 357
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
91-386 |
2.42e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 49.47 E-value: 2.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 91 ILVNTFLYAVCFWIQMGVLP-YLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGIL- 168
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSlFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLf 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 169 -GLANSATLIFI---------SRIPSLFLHAFQgtqmvISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQ 238
Cdd:cd17471 81 aFLRNYWVLLLVgvvllslgaAAFPQLFALARE-----YADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 239 SAAAVACIGSCVSLSLVILFIPGNTKPVQSTSAKDKSSDSvfsiktfthlmRSSPGAAFFLSVNLLAGLPSAIFSSMFAL 318
Cdd:cd17471 156 GLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKA-----------PVNRRLLLLFAAFTLLFAANSMYIIAMPL 224
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1752404508 319 VVIDKFELTADQNGYFLSFQGLASIVMQgVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWQL 386
Cdd:cd17471 225 YVTNELGGSESWVGLLFGLAAALEIPIM-LLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQL 291
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
335-466 |
4.17e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 48.81 E-value: 4.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 335 LSFQGLASIVMQgVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWQLTAVLLPMTCGNCITTT-VITSVLTKAVP 413
Cdd:cd17355 44 FTVGLLAFGLAQ-PFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAaVAFATVAAWWF 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1752404508 414 ASESGTILGLTHAGTSLLGTLAPIIGAVLLTNLGF-PSLGITGAVINIVLLLVL 466
Cdd:cd17355 123 ERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWrTALLVLALLALLVLVPVL 176
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
90-259 |
8.31e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.97 E-value: 8.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 90 VILVNTFLYAVCFWIQMGVLPYLTKK-FDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGIL 168
Cdd:COG2211 232 LLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 169 GLANSATLIFIsRIPSLFLHAFQGTQMV-----ISDLSDEA-----GRTEAL--GRVSMCYSIGIVVGPLIGGWIS---- 232
Cdd:COG2211 312 FFLGPGNLWLL-LVLAALAGIGLGAILVlpwamLADVVDYDewktgRRREGLyfGIFTFAIKLGQALAGALAGLLLalfg 390
|
170 180
....*....|....*....|....*...
gi 1752404508 233 -VSMSEQSAAAVACIGSCVSLSLVILFI 259
Cdd:COG2211 391 yVAGAAQSPSALTGIRLLFFLLPAVLLL 418
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
108-467 |
1.68e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 46.79 E-value: 1.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 108 VLPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILGLANSATLIFISRIpsLFL 187
Cdd:COG2807 40 LLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTA--LIG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 188 HAFQGTQMVI-----SDLSDEAGRteALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACIGSCVSLSLVILFIPGN 262
Cdd:COG2807 118 AGIAVGNVLLpglikRWFPDRVGL--MTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 263 TKPVQSTSAKdkssdsvfsiKTFTHLMRSSPgaafFLSVNLLAGLPSAIFSSMFALVV---IDKfELTADQNGYFLSFQG 339
Cdd:COG2807 196 PAAAAAAPAA----------ASLRSLWRSPL----AWLLTLFFGLQSLLYYAVVAWLPpilRDA-GLSAATAGLLLSLFQ 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 340 LASIVMqGVVIGRLTKRY-SEMKLLRASAILLAASYMAMCLVQDVWQLTAVLLPMTCGNCITTTVITSVLTKAVPASESG 418
Cdd:COG2807 261 LAGIPG-SLLVPLLADRLgDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAA 339
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1752404508 419 TILGLTHAGTSLLGTLAPIIGAVLLTNLGFPSLGITGAVINIVLLLVLT 467
Cdd:COG2807 340 ALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAG 388
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
141-466 |
3.15e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 46.05 E-value: 3.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 141 YGRFGDVYGGRA--ALGLAYLSAAAIygILGLANSATLIFISRipslflhAFQGTQMV-------ISDLSDEAGRTEALG 211
Cdd:cd17472 52 FGLLSDRIGRKPviLFGLLLFIAGSL--LAAYATSIYGLILGR-------ALQGSGAIssvvmalLADLTREENRTKAMA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 212 RVSM----CYSIGIVVGPLIGGWISVSmseqSAAAVACIGSCVSLSLVILFIPGNTKPVQStsaKDKSSDSVFSIKTFTH 287
Cdd:cd17472 123 LIGAsigiAFAISMVLGPLLAAHLGVS----GLFLITAILSLVSLLILLFFVPDPPKIVQI---SEKEKKKLKKLLKNKR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 288 LMRsspgaaFFLSVNLLAGLPSAIFsSMFALVVIDKFELTADQNGYFLSFQGLASIVMQGVVIgrLTKRYSEMKLLRASA 367
Cdd:cd17472 196 LLR------LDFSIFILHFVLMAFF-YILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVI--YAEKKGKMKQVFVSS 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 368 ILL-AASYMAM-CLVQDVWQL-TAVLLPMTCGNCItTTVITSVLTKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLT 444
Cdd:cd17472 267 ILLiAVGFLLLlFAATSLWLLiIGLIIFFIGFNLL-EALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWG 345
|
330 340
....*....|....*....|..
gi 1752404508 445 NLGFPSLGITGAVINIVLLLVL 466
Cdd:cd17472 346 LLGYSSVFLTILILALLWLLVS 367
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
108-453 |
5.43e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 45.24 E-value: 5.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 108 VLPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILGLANS----ATLIFISRIP 183
Cdd:cd17478 18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNywllLLLVALAGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 184 SLFLHAfQGTQMViSDLSDEAgRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACIGSCVSLSLVILFIPGNT 263
Cdd:cd17478 98 SAAFHP-EGARLA-SQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKK 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 264 KPVQSTSAKDKSSDSVFSIktfthlmrsspgAAFFLSVNLLAGLPSAIFSSMFALVVidkFELTadQNGYFLSFQGLASI 343
Cdd:cd17478 175 PEAKKAAAKSSARSTLKGV------------WRALLLLLIIVFLRSWVLSSLTTFLP---FYLV--QRGYSLVFAGLLLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 344 VMQGVVI------GRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWqlTAVLLPMTCGNCITTTVITSVLT-KAVPASE 416
Cdd:cd17478 238 LFLFAGAigtligGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIW--SYILLVLAGFLLFASFPVTVVLAqELLPGNV 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1752404508 417 ---SGTILGLTH----AGTSLLGTLAPIIG--AVLLTNLGFPSLGI 453
Cdd:cd17478 316 glaSGLMMGLSFglggIGAPVLGALADAFGleSVLLILALLPLLGA 361
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
90-258 |
1.61e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.69 E-value: 1.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 90 VILVNTFLYAVCFwIQMGVLPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILG 169
Cdd:cd17370 204 LYLLAVALFALGN-FSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFA 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 170 LANSATLIFISRIPSLFLHAFQGTQM--VISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACIG 247
Cdd:cd17370 283 LGSSLWLLLLGFILWGLYMGAQESIEraAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVL 362
|
170
....*....|.
gi 1752404508 248 ScvSLSLVILF 258
Cdd:cd17370 363 A--LIALLLLL 371
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
309-461 |
1.70e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 43.77 E-value: 1.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 309 SAIFSSMFALVVI--DKFELTADQNGYFLSFQGLASIVMQgVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWQL 386
Cdd:cd17475 9 SLVAQGIPALAPFlqEDLHLSLAQVGLLLSALNLGVAVSM-LPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVL 87
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1752404508 387 TAVLLPMTCGNcittTVITSVLTKAV----PASESGTILGLTHAGTSLLGTLAPIIGAVLLTNLGFPSLGITGAVINIV 461
Cdd:cd17475 88 LVLLFLVGAGY----GSVQPGGGRAImrwfPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSIL 162
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
107-432 |
2.26e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 43.38 E-value: 2.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 107 GVLPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRA--ALGLAYLSAAAIYGilGLANSATLIFISRips 184
Cdd:cd17328 20 GVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWilAVGILIWSAATLLS--SFAPNFWQLLLFR--- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 185 lflhAFQGT---------QMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWI-SVSMSEQSAAAVACIGSCVSLSL 254
Cdd:cd17328 95 ----ALVGIgeasyspiaPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaQATGGWRWAFRVTGVLGVLLAIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 255 VILFIP------GNTKPVQSTSAKDKSSD--SVFSIKTFTHLMRSSPGAAFFLSvNLLAGLPSAIFSsmfALVVIDKFEl 326
Cdd:cd17328 171 LLLFVRepprgaAEGGVMAKSTATSFLADlkALAKNPSFILSTLGFTAVSFVTG-ALAFWAPTFFLR---AFGVGDLSS- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 327 tADQNGYFLSFQGLASIVmqGVVIGRLTKRYSEMKLLRASAILLAAS--------YMAMCLVQDVWQLTAVLL-PMTCGN 397
Cdd:cd17328 246 -ADVGLIFGAITCIAGVL--GVLLGGILADRLRRKTPRADPLVCAVGllaaapflFLALVLALSNLLLAWVLLfLGEFLL 322
|
330 340 350
....*....|....*....|....*....|....*
gi 1752404508 398 CITTTVITSVLTKAVPASESGTILGLTHAGTSLLG 432
Cdd:cd17328 323 SLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLG 357
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
142-466 |
2.63e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.92 E-value: 2.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 142 GRFGDVYGGRAALGLA-YLSAAAIYGILGLANSATLIFISRIPSLFLHAFQG--TQMVISDLSDEAGRTEALGRVSMCYS 218
Cdd:cd17370 55 GYLSDRTGKRKPLVILgYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTppRDALLADATPPSGRGKAFGLHRALDT 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 219 IGIVVGPLIGGWI--SVSMSEQSAAAVACIGSCVSLSLVILFIPGNTKPVQSTSAKDKSSDSVFSIKTFTHLMRSSPGAA 296
Cdd:cd17370 135 LGAVLGPLLAALLlyLLGGNYRTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFAL 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 297 FFLSVNLLA------GLPSAIFSSMFALvvidkfeltadqngyFLSFQGLASIVmqgvvIGRLTKRYSEMKLLRASAILL 370
Cdd:cd17370 215 GNFSFAFLIlraqelGLSAALIPLLYAL---------------FNLVYALAAYP-----AGRLSDRIGRKKLLILGYLSL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 371 AASYMAMCLVQDVWQLTAVLLPMTCGNCITTTVITSVLTKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTNLGFPS 450
Cdd:cd17370 275 ALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSA 354
|
330
....*....|....*.
gi 1752404508 451 LGITGAVINIVLLLVL 466
Cdd:cd17370 355 AFLFSAVLALIALLLL 370
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
108-260 |
2.95e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 43.11 E-value: 2.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 108 VLPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILGLANSATLIFISR-IPSLF 186
Cdd:TIGR00895 39 AAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRfLAGLG 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1752404508 187 LHAFQGTQMVI-SDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACIGSCVSLSLVILFIP 260
Cdd:TIGR00895 119 LGGLMPNLNALvSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLP 193
|
|
| PUCC |
pfam03209 |
PUCC protein; This protein is required for high-level transcription of the PUC operon. |
141-443 |
3.81e-04 |
|
PUCC protein; This protein is required for high-level transcription of the PUC operon.
Pssm-ID: 367394 Cd Length: 401 Bit Score: 42.73 E-value: 3.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 141 YGRFGDVYGGRAAL--GLAYLSAAAIYGILGLANSATLIFISRIPSLFLHAFQGTQMVIS---------DLSDEAGRTEA 209
Cdd:pfam03209 46 WKRTPYIWLGSLAQagGLAIMPFALIVLSGSGDANGAPTWAGLILAAVAFLLYGLGVHMSqtpglalaaDLADEERRPKV 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 210 LGRVSMCYSIGIVVGPLIGGWISVSMSE----QSAAAVACIGSCVSLSLVILFIPGNTKPVQSTSAKDKSSDSVFSiktf 285
Cdd:pfam03209 126 VGIMWVMLLIGIIVSAITVGWLLDDYTParliRVIQGVALITFVLNIIALWKIEVGRPSRPAERPEQDPSFLEAWL---- 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 286 thLMRSSPGAAFFLSVNLLA----GLPSAIFSS----MFALVVIDKFELTADQNGYFLSFQGLASIVM-QGVVIGRLTKR 356
Cdd:pfam03209 202 --LLVAEPQALIFLFFLFLGtlafFMQDVILEPyggeVFGLTVGETTKLTAFFAGGTLVGFGLAGRVLsPGLGPGRLAGL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 357 YSEMKLLRASAILLAAsymamcLVQDVWQLTAVLLPMTCGNCITTTVITSVLTKAVPASESGTILGLTHAGTSLLGTLAP 436
Cdd:pfam03209 280 GCLLGLPSFLALILAG------LLGNVALFFAGVLLFGLGGGLFTVAALTAMMDLAPEGRAGTALGAWGAAQATAAGLAG 353
|
....*..
gi 1752404508 437 IIGAVLL 443
Cdd:pfam03209 354 LLGGALR 360
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
128-466 |
4.39e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 42.26 E-value: 4.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 128 TFFSGIMLVGGPIYGRFGDVYGGRA--ALGLAYLSAA--------------AIYGILGLANSATLifisripslflhaFQ 191
Cdd:cd17355 45 TVGLLAFGLAQPFVGRLLDRFGPRRvmLLGLLLLAAGlvllalatslwqlyLLWGLLGGGGAGTL-------------AA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 192 GTQMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACIGSCVSLSLVILFIPGNTKPVQSTSA 271
Cdd:cd17355 112 VAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAY 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 272 KDKSSDSVFSikTFTHLMRSSPG----AAFF--------LSVNLLAGLPSAIFSSMFALVVidkfeltadqngyfLSFQG 339
Cdd:cd17355 192 DDASPASPGS--TLKEALRSASFwllaLAFFlcgfavvgLIVHLVPYLADRGISPAAAAVA--------------LALIG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 340 LASIVMQgVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWQLTAVLLPMTCGNCITTTVITSVLT-KAVPASESG 418
Cdd:cd17355 256 LFNIVGR-LLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAaRYFGARSYG 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1752404508 419 TILGLTHAGTSLLGTLAPIIGAVLLTNLGfpslGITGAVINIVLLLVL 466
Cdd:cd17355 335 TLFGLVFAPHQLGSALGPWLGGLLYDRTG----SYTAAWALAVALGLI 378
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
92-260 |
7.63e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 41.52 E-value: 7.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 92 LVNTFLYAVCFWIQMGVLPYLTKKFDMDMV-TFGYLQTFFSGiMLVGGPIYGRFGDVYGGRAALGL-AYLSAAAIYGILG 169
Cdd:cd17371 216 LLATGALGGYYGITTWLPSYLTGERGLSFEgSAGYLVVTILG-GFLGYLAGGFLADRIGRRNNFALfALGSAISILLYFF 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 170 LANSATLIFISRIPSLFLH--AFQGTQMVISDLSDEAGRTEALGrvsMCYSIGIVVG---PLIGGWISVSMSEQSAAAVA 244
Cdd:cd17371 295 LPLSPTLILILGFPLGFFAsgPFSGMGAYLTELFPTAVRATAQG---FCYNVGRIIGalfPFLVGFLATSGSLGTAIAVF 371
|
170
....*....|....*.
gi 1752404508 245 CIGSCVSLSLVILFIP 260
Cdd:cd17371 372 AAVYYIAGLVLALLLP 387
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
302-468 |
1.23e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 40.56 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 302 NLLAGLPSAIFSSMFALVVIDkFELTADQNGYFLSFQGLASIVMqGVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQ 381
Cdd:COG0477 23 TFLEGLDFTIVNVALPSIAAD-LGASSAQLGWIVSAYLLGRAIG-LLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAP 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 382 DVWQLTAVLLPMTCGNCITTTVITSVLTKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTNLGFPSLGITGAVINIV 461
Cdd:COG0477 101 SPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLL 180
|
....*..
gi 1752404508 462 LLLVLTK 468
Cdd:COG0477 181 ALVLRLR 187
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
90-258 |
1.39e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.87 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 90 VILVNTFLYAVCFWIQMGVLPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAI-YGIL 168
Cdd:cd06174 208 LLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALgLALL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 169 GLANSATLIFISRIPSLFLHA-FQGTQMV-ISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACI 246
Cdd:cd06174 288 LLAPSLLLLLLLLLLLGFGLGgLLPLSFAlIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLA 367
|
170
....*....|..
gi 1752404508 247 GSCVsLSLVILF 258
Cdd:cd06174 368 VLLL-LAAILLL 378
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
65-258 |
2.25e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 40.25 E-value: 2.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 65 HREKTDLRQQHSLHQTNVNMNVVKSVILVNTFLYAVCFWIQMGVLP-YLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGR 143
Cdd:cd17474 177 KEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPfLLELLYGISPIIIGLLFAGWSVLLALGSLFVGR 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 144 FGDV-YGGRAALGLAYLSAAAIYGILGLANSATLIFIsriPSLFLHAFQGTQM-VISDLSDEAGRTEALGRVSMCYS--- 218
Cdd:cd17474 257 LLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLI---AIVLFGLGLGLNLpLLTTLVTELAPEEERGTASSLYNfvr 333
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1752404508 219 -IGIVVGPLIGGWISVSMSEQSAAAVACIGSCVSLSLVILF 258
Cdd:cd17474 334 fLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
154-466 |
2.60e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.90 E-value: 2.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 154 LGLAYLSAAAIygILGLANSATLIFISRIPSLFLHAFQGTQMVI-SDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWIS 232
Cdd:cd17490 67 IGLLFTVLASL--IMILFPSPWGLLIARFLSGIAAATWVSFTVLyASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 233 VSMSEQSAAAVACIGSCVSLsLVILFIPGNTKPVQSTSAKDKSSDSVFSIKTfthlmrsspgaafFLSVNLLAGLPSAI- 311
Cdd:cd17490 145 EHFGMRAPFLLAALAGVLGF-ILSLFIKEERREKKPVLTELKELLSVLKDKK-------------LLFFSLLAILQQMIt 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 312 FSSMFALVVIDKFELTAD--QNGYFLSFQGLASIVMQGVVIGRLTKRYSEMKLLRASAILLAASYMAMCLVQDVWQLTAV 389
Cdd:cd17490 211 FSTTFGFTPLIAKQLGASsfQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLL 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 390 LLPMTCGNCITTTVITSVLTKAVPASESGTILGLTHAGTSLLGTLAPIIGAVLLTNLG----FPSLGITGAVINIVLLLV 465
Cdd:cd17490 291 QALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGlqtgFFVIGVIALLAAILSLAY 370
|
.
gi 1752404508 466 L 466
Cdd:cd17490 371 Y 371
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
135-446 |
4.05e-03 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 39.18 E-value: 4.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 135 LVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILGL------ANSATLIFISRIPSLFLHAFQGTQM----VISDLSDEA 204
Cdd:cd17386 44 LFSSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLivyfttVPSVWWFYLSAIPLALFGGFTAFLSasfaYISDISSEK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 205 GRTEALGRVSMCYSIGIVVGPLIGGWISVSMSeqSAAAVACIGSCVSLSLVILFipgntkpvqstsakdkssdsvFSIKT 284
Cdd:cd17386 124 KRTYRMAILEVALGLGGFLGSLLSGHLFKALG--YAWSFSISAALLLIALLYIL---------------------FFLTL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 285 FTHLMrsspgAAFFLSVNLLAGLPSaifssMFALVVIDKFELTADQNGYFLSFQGLASIVmqGVVIGRLTKRysemKLLR 364
Cdd:cd17386 181 LILLL-----LAAFLTIFVLSGESD-----VLYLFVLEKFAWNVKDFSYFSTLGSLIYLT--GMLGGVLLLR----CLLK 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 365 ASAILLAASYMAMCLVQDVWQLTAVLLPM---TCG----NCITTTVITSVLTKAVPASESGTILGLthagTSLLGTLAPI 437
Cdd:cd17386 245 MSDSTLAMLGLASHILSSLLFAFATNTWMmylAAVvgmfNGIVGPMIRSILSKLVPKSEQGKIFSL----LSVLESLSPL 320
|
....*....
gi 1752404508 438 IGAVLLTNL 446
Cdd:cd17386 321 VASPIYNNI 329
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
108-467 |
4.43e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.12 E-value: 4.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 108 VLPYLTKKFDMDMVTFGYLQTFFSGI--MLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILGLANSATLIFISR-IPS 184
Cdd:cd17316 21 VAPVLAAEFSLGLSLLQTGLLFAAGFlgRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRfLQG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 185 LFLHA-FQGTQMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACIGSCVsLSLVILFIPGNT 263
Cdd:cd17316 101 IGIGGeYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGAL-PALLALLLRRRT 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 264 kpvqstsakdkssdsvfsiktfthlmrsspgaAFFLSVNLLAGLPSAIFSSMFALVVIDKFELTADQNGYFLSFQGLASI 343
Cdd:cd17316 180 --------------------------------LLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGAL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 344 VMqGVVIGRLTKRYSEMKLLRASAILLAASY--MAMCLVQDVWQLTAVLLPMTCGNCITTTVITSVLTKAVPASESGTIL 421
Cdd:cd17316 228 VG-ALIAGLLSDRIGRKKTLVIGLILSGILAlpLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGV 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1752404508 422 GLTHAGTSLLGTLAPIIGAVLLTNLGFPSLGITGAVINIVLLLVLT 467
Cdd:cd17316 307 GLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVA 352
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
91-236 |
5.75e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 38.70 E-value: 5.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 91 ILVNTFLYAVCFWIQMGVLPYLTKKFDmDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRaalgLAYLSAAAIYGI--- 167
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRK----WVLLIAIVIFELgsl 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1752404508 168 -LGLANSATLIFISRipslflhAFQG---------TQMVISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMS 236
Cdd:cd17502 76 lCGLAPNMTMLIVGR-------AIQGigggglmslAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLS 147
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
299-465 |
7.15e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 38.39 E-value: 7.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 299 LSVNLLAGLPSAIFSSMFALV--VIDKFELTADQNGYFLSFQGLASIVmQGVVIGRLTKRYSEMKLLRASAILLAASYMA 376
Cdd:cd17393 2 LAVAAFFFINGILMASWATRIpaIKDRLGLSDAALGLLLLALGVGALV-AMPLAGRLVARFGSRRVTRLGALLLLLALLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 377 MCLVQDVWQLTAVLLPMTCGNCITTTVItSVLTKAVPASESGTILGLTHAGTSlLGTLAPIIGAVLLTNLGFPSLGITG- 455
Cdd:cd17393 81 LGLAPSVPALALALFLFGAANGALDVAM-NAQGVAVERAYGRPIMSSLHAMWS-LGGLAGALLGAAAIGAGVSPGVHLLa 158
|
170
....*....|.
gi 1752404508 456 -AVINIVLLLV 465
Cdd:cd17393 159 aAVLLLLAALV 169
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
90-257 |
8.20e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.35 E-value: 8.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 90 VILVNTFLYAVCFWIQMGVLPYLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSA---AAIYG 166
Cdd:cd17316 182 LILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSgilALPLF 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 167 ILGLANSATLIFISRIPSLFLHAFQGTQMV-ISDLSDEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVAC 245
Cdd:cd17316 262 YLLSGSPTLLLLLLFILSFFVGGVWGALYAyLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALIL 341
|
170
....*....|..
gi 1752404508 246 IGSCVSLSLVIL 257
Cdd:cd17316 342 ALLAIVALIVAL 353
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
92-232 |
8.20e-03 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 38.45 E-value: 8.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 92 LVN-TFLYavcfWiqmgvLP-YLTKKFDMDMVTFGYLQTFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAA------ 163
Cdd:cd17344 225 LVSyTFLY----W-----LPlYISNTAILSAKKAGDLSTLFDVGGIVGGILAGYISDYTGGRATTCAAMLILAApmlfiy 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 164 -IYGILGLANSATLIFISRI----PSLFLhafqgTQMVISDLSDEA---GRTEALGRVSMCY----SIGIVVGPLIGGWI 231
Cdd:cd17344 296 nYFGQVSMTTNIVLLIVCGLlvngPYALI-----TTAVSADLGTHKslkGNARALATVTAIIdgtgSIGAALGPLLAGLI 370
|
.
gi 1752404508 232 S 232
Cdd:cd17344 371 S 371
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
128-364 |
8.41e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 38.36 E-value: 8.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 128 TFFSGIMLVGGPIYGRFGDVYGGRAALGLAYLSAAAIYGILGLANSATLIFISRipslFLHAFQG------TQMVISDLS 201
Cdd:PRK11102 33 SAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMR----FLHGLAAaaasvvINALMRDMF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 202 DEAGRTEALGRVSMCYSIGIVVGPLIGGWISVSMSEQSAAAVACIGSCVSLSLVILFIPgntkpvqSTSAKDKSSDsvFS 281
Cdd:PRK11102 109 PKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIP-------ETLPKERRQP--FH 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1752404508 282 IKT----FTHLMRSSpgAAFFLsvnLLAGLPSaiFSSMFA------LVVIDKFELTADQNGYFLSFQGLASIVMQgVVIG 351
Cdd:PRK11102 180 LRTtirnFASLFRHK--RVLGY---MLASGFS--FAGMFSfltagpFVYIELNGVSPQNFGYYFALNIVFLFVMT-IINS 251
|
250
....*....|...
gi 1752404508 352 RLTKRYSEMKLLR 364
Cdd:PRK11102 252 RFVRRVGALNMLR 264
|
|
| |
