|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
13-254 |
1.12e-71 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 220.57 E-value: 1.12e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 13 IGIGTGTsikDLKRGQPTAENKArIVDILRYALSIGYNHIDTAEVYTTQPEVGTAIA--GFQREKLWITTKYSVTSSMIK 90
Cdd:cd19120 7 IAFGTGT---AWYKSGDDDIQRD-LVDSVKLALKAGFRHIDTAEMYGNEKEVGEALKesGVPREDLFITTKVSPGIKDPR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 91 KKsftptdfVEQALDEMNTNYIDLLLIHFPP-KPNDPYTIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGT--P 167
Cdd:cd19120 83 EA-------LRKSLAKLGVDYVDLYLIHSPFfAKEGGPTLAEAWAELEALKDAGLVRSIGVSNFRIEDLEELLDTAKikP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 168 TINQIQY--YLGSDNLEVVEFCKNHGILVEAYGPLTPL-RNPNPKTDALIEKLQNANHLTKSQALFRYLLDNNILPITTS 244
Cdd:cd19120 156 AVNQIEFhpYLYPQQPALLEYCREHGIVVSAYSPLSPLtRDAGGPLDPVLEKIAEKYGVTPAQVLLRWALQKGIVVVTTS 235
|
250
....*....|
gi 68482081 245 FKKERLKEAL 254
Cdd:cd19120 236 SKEERMKEYL 245
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
13-252 |
5.62e-63 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 197.70 E-value: 5.62e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 13 IGIGTGTSIKDlkrgqptaenkaRIVDILRYALSIGYNHIDTAEVYTTQPEVGTAIA--GFQREKLWITTKysvtssmik 90
Cdd:cd19071 4 IGLGTYKLKPE------------ETAEAVLAALEAGYRHIDTAAAYGNEAEVGEAIResGVPREELFITTK--------- 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 91 kksFTPTDF--------VEQALDEMNTNYIDLLLIHFP---PKPNDPYTIQSLWQEFVSIKATGKVRYIGVSNFDIPQLN 159
Cdd:cd19071 63 ---LWPTDHgyervreaLEESLKDLGLDYLDLYLIHWPvpgKEGGSKEARLETWRALEELVDEGLVRSIGVSNFNVEHLE 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 160 TLLEIGT--PTINQIQYYLGSDNLEVVEFCKNHGILVEAYGPLTPLRNPnPKTDALIEKLQNANHLTKSQALFRYLLDNN 237
Cdd:cd19071 140 ELLAAARikPAVNQIELHPYLQQKELVEFCKEHGIVVQAYSPLGRGRRP-LLDDPVLKEIAKKYGKTPAQVLLRWALQRG 218
|
250
....*....|....*
gi 68482081 238 ILPITTSFKKERLKE 252
Cdd:cd19071 219 VVVIPKSSNPERIKE 233
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
38-252 |
9.22e-56 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 179.48 E-value: 9.22e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 38 VDILRYALSIGYNHIDTAEVYTTQPEVGTAIA--GFQREKLWITTKysvtssmikkksFTPTDF--------VEQALDEM 107
Cdd:COG0656 21 AAAVRTALEAGYRHIDTAAMYGNEEGVGEAIAasGVPREELFVTTK------------VWNDNHgyddtlaaFEESLERL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 108 NTNYIDLLLIHFPPkpndPYTIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEI--GTPTINQIQYYLGSDNLEVVE 185
Cdd:COG0656 89 GLDYLDLYLIHWPG----PGPYVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAEtgVKPAVNQVELHPYLQQRELLA 164
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 186 FCKNHGILVEAYGPL---TPLRNPnpktdaLIEKLQNANHLTKSQALFRYLLDNNILPITTSFKKERLKE 252
Cdd:COG0656 165 FCREHGIVVEAYSPLgrgKLLDDP------VLAEIAEKHGKTPAQVVLRWHLQRGVVVIPKSVTPERIRE 228
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
38-254 |
4.76e-46 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 153.97 E-value: 4.76e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 38 VDILRYALSIGYNHIDTAEVYTTQPEVGTAIAGFQ--REKLWITTKysVTSSMIKKKSFTPtdFVEQALDEMNTNYIDLL 115
Cdd:cd19073 17 ANAVKEALELGYRHIDTAEIYNNEAEVGEAIAESGvpREDLFITTK--VWRDHLRPEDLKK--SVDRSLEKLGTDYVDLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 116 LIHFppkPNDPYTIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGT--PTINQIQYYLGSDNLEVVEFCKNHGIL 193
Cdd:cd19073 93 LIHW---PNPTVPLEETLGALKELKEAGKVKSIGVSNFTIELLEEALDISPlpIAVNQVEFHPFLYQAELLEYCRENDIV 169
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68482081 194 VEAYGPL---TPLRNPnpktdaLIEKLQNANHLTKSQALFRYLLDNNILPITTSFKKERLKEAL 254
Cdd:cd19073 170 ITAYSPLargEVLRDP------VIQEIAEKYDKTPAQVALRWLVQKGIVVIPKASSEDHLKENL 227
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
13-256 |
1.71e-44 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 150.84 E-value: 1.71e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 13 IGIGTGTSIKdlkRGQPTAENKARIVDILRYALSIGYNHIDTAEVY---TTQPEVGTAIAGFQREKLWITTKYSVTSSMI 89
Cdd:cd19072 7 LGLGTWGIGG---GMSKDYSDDKKAIEALRYAIELGINLIDTAEMYgggHAEELVGKAIKGFDREDLFITTKVSPDHLKY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 90 K--KKSFtptdfvEQALDEMNTNYIDLLLIHFppkPNDPYTIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEI--- 164
Cdd:cd19072 84 DdvIKAA------KESLKRLGTDYIDLYLIHW---PNPSIPIEETLRAMEELVEEGKIRYIGVSNFSLEELEEAQSYlkk 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 165 GTPTINQIQYYLGSDNLE--VVEFCKNHGILVEAYGPLTPLRNPNPKTDALIEKLQNANHLTKSQALFRYLL-DNNILPI 241
Cdd:cd19072 155 GPIVANQVEYNLFDREEEsgLLPYCQKNGIAIIAYSPLEKGKLSNAKGSPLLDEIAKKYGKTPAQIALNWLIsKPNVIAI 234
|
250
....*....|....*
gi 68482081 242 TTSFKKERLKEALHS 256
Cdd:cd19072 235 PKASNIEHLEENAGA 249
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
37-255 |
2.20e-44 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 150.47 E-value: 2.20e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 37 IVDILRYALSIGYNHIDTAEVYTTQPEVGTAIA------GFQREKLWITTKYSvTSSMIKKKSftpTDFVEQALDEMNTN 110
Cdd:cd19136 17 VRQAVDAALKAGYRLIDTASVYRNEADIGKALRdllpkyGLSREDIFITSKLA-PKDQGYEKA---RAACLGSLERLGTD 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 111 YIDLLLIHFP----PKPNDP----YTIQSlWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGT--PTINQIQYYLGSDN 180
Cdd:cd19136 93 YLDLYLIHWPgvqgLKPSDPrnaeLRRES-WRALEDLYKEGKLRAIGVSNYTVRHLEELLKYCEvpPAVNQVEFHPHLVQ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 181 LEVVEFCKNHGILVEAY-----GPLTPLRNPNPKtdALIEKLQNanhlTKSQALFRYLLDNNILPITTSFKKERLKEALH 255
Cdd:cd19136 172 KELLKFCKDHGIHLQAYsslgsGDLRLLEDPTVL--AIAKKYGR----TPAQVLLRWALQQGIGVIPKSTNPERIAENIK 245
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
12-252 |
1.33e-42 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 146.66 E-value: 1.33e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 12 TIGIGTGTSIKDLKrgqptaenkarIVDILRYALSIGYNHIDTAEVYTTQPEVGTAIA------GFQREKLWITTKYSvt 85
Cdd:cd19116 13 AIALGTWKLKDDEG-----------VRQAVKHAIEAGYRHIDTAYLYGNEAEVGEAIRekiaegVVKREDLFITTKLW-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 86 ssmikkKSFTPTDFVEQALDE----MNTNYIDLLLIHFP--------PKPNDPYTIQSL-----WQEFVSIKATGKVRYI 148
Cdd:cd19116 80 ------NSYHEREQVEPALREslkrLGLDYVDLYLIHWPvafkenndSESNGDGSLSDIdyletWRGMEDLVKLGLTRSI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 149 GVSNFDIPQLNTLLEIGT--PTINQIQYYLGSDNLEVVEFCKNHGILVEAYGPL-----TPLRNPNPK-TDALIEKLQNA 220
Cdd:cd19116 154 GVSNFNSEQINRLLSNCNikPAVNQIEVHPTLTQEKLVAYCQSNGIVVMAYSPFgrlvpRGQTNPPPRlDDPTLVAIAKK 233
|
250 260 270
....*....|....*....|....*....|..
gi 68482081 221 NHLTKSQALFRYLLDNNILPITTSFKKERLKE 252
Cdd:cd19116 234 YGKTTAQIVLRYLIDRGVVPIPKSSNKKRIKE 265
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
38-254 |
7.85e-42 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 143.55 E-value: 7.85e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 38 VDILRYALSIGYNHIDTAEVYTTQPEVGTAIA--GFQREKLWITTKysVTSSMIKKKSFTPTdfVEQALDEMNTNYIDLL 115
Cdd:cd19140 24 TRAVEHALELGYRHIDTAQMYGNEAQVGEAIAasGVPRDELFLTTK--VWPDNYSPDDFLAS--VEESLRKLRTDYVDLL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 116 LIHFPPK--PNDPyTIQSLwqefVSIKATGKVRYIGVSNFDIPQLNTLLEIGTPTI--NQIQYYLGSDNLEVVEFCKNHG 191
Cdd:cd19140 100 LLHWPNKdvPLAE-TLGAL----NEAQEAGLARHIGVSNFTVALLREAVELSEAPLftNQVEYHPYLDQRKLLDAAREHG 174
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68482081 192 ILVEAYGPLTplRNPNPKtDALIEKLQNANHLTKSQALFRYLLD-NNILPITTSFKKERLKEAL 254
Cdd:cd19140 175 IALTAYSPLA--RGEVLK-DPVLQEIGRKHGKTPAQVALRWLLQqEGVAAIPKATNPERLEENL 235
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
43-252 |
6.40e-41 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 141.69 E-value: 6.40e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 43 YALSI-GYNHIDTAEVYTTQPEVGTAIA--GFQREKLWITTK-------YSVTssmikKKSFtptdfvEQALDEMNTNYI 112
Cdd:cd19135 33 YALKEcGYRHIDTAKRYGCEELLGKAIKesGVPREDLFLTTKlwpsdygYEST-----KQAF------EASLKRLGVDYL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 113 DLLLIHFP----PKPNDPYTIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGT--PTINQIQYYLGSDNLEVVEF 186
Cdd:cd19135 102 DLYLLHWPdcpsSGKNVKETRAETWRALEELYDEGLCRAIGVSNFLIEHLEQLLEDCSvvPHVNQVEFHPFQNPVELIEY 181
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68482081 187 CKNHGILVEAYGPLTP---LRNPNpktdalIEKLQNANHLTKSQALFRYLLDNNILPITTSFKKERLKE 252
Cdd:cd19135 182 CRDNNIVFEGYCPLAKgkaLEEPT------VTELAKKYQKTPAQILIRWSIQNGVVTIPKSTKEERIKE 244
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
32-252 |
9.64e-39 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 135.98 E-value: 9.64e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 32 ENKARIVDILRYALSIGYNHIDTAEVYTTQPEVGTAIA--GFQREKLWITTK-------YSVTSsmikkKSFtptdfvEQ 102
Cdd:cd19157 21 EEGSEVVNAVKTALKNGYRSIDTAAIYGNEEGVGKGIKesGIPREELFITSKvwnadqgYDSTL-----KAF------EA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 103 ALDEMNTNYIDLLLIHFPPKpnDPYtiQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIG--TPTINQIQYYLGSDN 180
Cdd:cd19157 90 SLERLGLDYLDLYLIHWPVK--GKY--KETWKALEKLYKDGRVRAIGVSNFQVHHLEDLLADAeiVPMVNQVEFHPRLTQ 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 68482081 181 LEVVEFCKNHGILVEAYGPLTP---LRNPnpktdaLIEKLQNANHLTKSQALFRYLLDNNILPITTSFKKERLKE 252
Cdd:cd19157 166 KELRDYCKKQGIQLEAWSPLMQgqlLDNP------VLKEIAEKYNKSVAQVILRWDLQNGVVTIPKSIKEHRIIE 234
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
33-252 |
7.83e-38 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 134.46 E-value: 7.83e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 33 NKARIVDILRYALSIGYNHIDTAEVYTTQPEVGTAIAGF------QREKLWITTKYSVTssmikkksFTPTDFVEQALDE 106
Cdd:cd19154 23 KGAEGITAVRTALKAGYRLIDTAFLYQNEEAIGEALAELleegvvKREDLFITTKLWTH--------EHAPEDVEEALRE 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 107 ----MNTNYIDLLLIHFP-----------PKPN-----DPYTIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGT 166
Cdd:cd19154 95 slkkLQLEYVDLYLIHAPaafkddegesgTMENgmsihDAVDVEDVWRGMEKVYDEGLTKAIGVSNFNNDQIQRILDNAR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 167 --PTINQIQYYLGSDNLEVVEFCKNHGILVEAYGPL-TPLRN-----------PNPKTDALIEKLQNANHLTKSQALFRY 232
Cdd:cd19154 175 vkPHNNQVECHLYFPQKELVEFCKKHNISVTSYATLgSPGRAnftkstgvspaPNLLQDPIVKAIAEKHGKTPAQVLLRY 254
|
250 260
....*....|....*....|
gi 68482081 233 LLDNNILPITTSFKKERLKE 252
Cdd:cd19154 255 LLQRGIAVIPKSATPSRIKE 274
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
44-252 |
4.30e-37 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 132.08 E-value: 4.30e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 44 ALSIGYNHIDTAEVYTTQPEVGTAI-----AGF-QREKLWITTKYSVTSSmikkksfTPTDfVEQALD----EMNTNYID 113
Cdd:cd19125 33 AIKEGYRHIDCAAIYGNEKEIGKALkklfeDGVvKREDLFITSKLWCTDH-------APED-VPPALEktlkDLQLDYLD 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 114 LLLIHFP---------PKPND--PYTIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIG--TPTINQIQYYLGSDN 180
Cdd:cd19125 105 LYLIHWPvrlkkgahmPEPEEvlPPDIPSTWKAMEKLVDSGKVRAIGVSNFSVKKLEDLLAVArvPPAVNQVECHPGWQQ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 181 LEVVEFCKNHGILVEAYGPL----TPLRNPNPKTDALIEKLqnANHLTKS--QALFRYLLD--NNILPitTSFKKERLKE 252
Cdd:cd19125 185 DKLHEFCKSKGIHLSAYSPLgspgTTWVKKNVLKDPIVTKV--AEKLGKTpaQVALRWGLQrgTSVLP--KSTNEERIKE 260
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
42-252 |
1.13e-36 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 130.25 E-value: 1.13e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 42 RYALSIGYNHIDTAEVYTTQPEVGTAI--AGFQREKLWITTKysVTSSMIKKKsfTPTDFVEQALDEMNTNYIDLLLIHF 119
Cdd:cd19126 30 QTALENGYRSIDTAAIYKNEEGVGEAIreSGVPREELFVTTK--LWNDDQRAR--RTEDAFQESLDRLGLDYVDLYLIHW 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 120 PPKPNdpytIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIG--TPTINQIQYYLGSDNLEVVEFCKNHGILVEAY 197
Cdd:cd19126 106 PGKDK----FIDTWKALEKLYASGKVKAIGVSNFQEHHLEELLAHAdvVPAVNQVEFHPYLTQKELRGYCKSKGIVVEAW 181
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 68482081 198 gplTPLRNPNPKTDALIEKLQNANHLTKSQALFRYLLDNNILPITTSFKKERLKE 252
Cdd:cd19126 182 ---SPLGQGGLLSNPVLAAIGEKYGKSAAQVVLRWDIQHGVVTIPKSVHASRIKE 233
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
12-258 |
1.26e-36 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 131.08 E-value: 1.26e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 12 TIGIGTGTSIKDLKRG--QPTAENKARIVDIlryALSIGYNHIDTAEVYTTQPEVGTAI--AGFQREKLWITTKYSVTSS 87
Cdd:cd19117 5 TFKLNTGAEIPAVGLGtwQSKPNEVAKAVEA---ALKAGYRHIDTAAIYGNEEEVGQGIkdSGVPREEIFITTKLWCTWH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 88 MikkksfTPTDFVEQALDEMNTNYIDLLLIHFP----PKPNDP--------------YTIQSLWQEFVSIKATGKVRYIG 149
Cdd:cd19117 82 R------RVEEALDQSLKKLGLDYVDLYLMHWPvpldPDGNDFlfkkddgtkdhepdWDFIKTWELMQKLPATGKVKAIG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 150 VSNFDIPQLNTLLEIG----TPTINQIQYYLGSDNLEVVEFCKNHGILVEAYGPLTPLRNPNPKtDALIEKLQNANHLTK 225
Cdd:cd19117 156 VSNFSIKNLEKLLASPsakiVPAVNQIELHPLLPQPKLVDFCKSKGIHATAYSPLGSTNAPLLK-EPVIIKIAKKHGKTP 234
|
250 260 270
....*....|....*....|....*....|...
gi 68482081 226 SQALFRYLLDNNILPITTSFKKERLKEALHSYT 258
Cdd:cd19117 235 AQVIISWGLQRGYSVLPKSVTPSRIESNFKLFT 267
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
13-252 |
1.25e-35 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 128.38 E-value: 1.25e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 13 IGIGTGTSikdlkrgqPTAEnkarIVDILRYALSIGYNHIDTAEVYTTQPEVGTAI------AGFQREKLWITTK----Y 82
Cdd:cd19111 7 IGLGTYQS--------PPEE----VRAAVDYALFVGYRHIDTALSYQNEKAIGEALkwwlknGKLKREEVFITTKlppvY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 83 SVTSSMIKkksftptdFVEQALDEMNTNYIDLLLIHFPP----------KPNDPYTIQSLWQEFVSIKATGKVRYIGVSN 152
Cdd:cd19111 75 LEFKDTEK--------SLEKSLENLKLPYVDLYLIHHPCgfvnkkdkgeRELASSDVTSVWRAMEALVSEGKVKSIGLSN 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 153 FDIPQLNTLLEIG-TPTIN-QIQYYLGSDNLEVVEFCKNHGILVEAYGPL-TPLR--------NPNPKTDALIEKLQNAN 221
Cdd:cd19111 147 FNPRQINKILAYAkVKPSNlQLECHAYLQQRELRKFCNKKNIVVTAYAPLgSPGRanqslwpdQPDLLEDPTVLAIAKEL 226
|
250 260 270
....*....|....*....|....*....|.
gi 68482081 222 HLTKSQALFRYLLDNNILPITTSFKKERLKE 252
Cdd:cd19111 227 DKTPAQVLLRFVLQRGTGVLPKSTNKERIEE 257
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
37-254 |
1.90e-35 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 126.70 E-value: 1.90e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 37 IVDILRYALSIGYNHIDTAEVYTTQPEVGTAIA--GFQREKLWITTKysvtssmIKKKSFTPTDFV---EQALDEMNTNY 111
Cdd:cd19139 16 VIDSVRTALELGYRHIDTAQIYDNEAAVGQAIAesGVPRDELFITTK-------IWIDNLSKDKLLpslEESLEKLRTDY 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 112 IDLLLIHFPPkPNDPYTIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEI-GTPTI--NQIQY--YLgsDNLEVVEF 186
Cdd:cd19139 89 VDLTLIHWPS-PNDEVPVEEYIGALAEAKEQGLTRHIGVSNFTIALLDEAIAVvGAGAIatNQIELspYL--QNRKLVAH 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 68482081 187 CKNHGILVEAYGPLT---PLRNPnpktdaLIEKLQNANHLTKSQALFRYLLDNNILPITTSFKKERLKEAL 254
Cdd:cd19139 166 CKQHGIHVTSYMTLAygkVLDDP------VLAAIAERHGATPAQIALAWAMARGYAVIPSSTKREHLRSNL 230
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
44-254 |
1.10e-34 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 125.08 E-value: 1.10e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 44 ALSIGYNHIDTAEVYTTQPEVGTAI--AGFQREKLWITTK-------YSVTSSMIkkksftptdfvEQALDEMNTNYIDL 114
Cdd:cd19132 29 ALQAGYRLLDTAFNYENEGAVGEAVrrSGVPREELFVTTKlpgrhhgYEEALRTI-----------EESLYRLGLDYVDL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 115 LLIHFPPKPNDPYtIQSlWQEFVSIKATGKVRYIGVSNFDIPQLNTLL-EIG-TPTINQIQYYLGSDNLEVVEFCKNHGI 192
Cdd:cd19132 98 YLIHWPNPSRDLY-VEA-WQALIEAREEGLVRSIGVSNFLPEHLDRLIdETGvTPAVNQIELHPYFPQAEQRAYHREHGI 175
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 68482081 193 LVEAYGPLTplRNPNPKTDALIEKLQNANHLTKSQALFRYLLDNNILPITTSFKKERLKEAL 254
Cdd:cd19132 176 VTQSWSPLG--RGSGLLDEPVIKAIAEKHGKTPAQVVLRWHVQLGVVPIPKSANPERQRENL 235
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
15-251 |
1.11e-34 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 126.07 E-value: 1.11e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 15 IGTGTSIKDLKRGQptaenkarIVDILRYALSIGYNHIDTAEVYTTQPEVGTAI------AGFQREKLWITTKysvtssm 88
Cdd:cd19119 15 LGLGTASPHEDRAE--------VKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIkraiddGSIKREELFITTK------- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 89 ikkksFTPT--DFVEQALDE----MNTNYIDLLLIHFP---------------PKPNDPYTIQS-------LWQEFVSIK 140
Cdd:cd19119 80 -----VWPTfyDEVERSLDEslkaLGLDYVDLLLVHWPvcfekdsddsgkpftPVNDDGKTRYAasgdhitTYKQLEKIY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 141 ATGKVRYIGVSNFDIPQLNTLLEIG--TPTINQIQYYLGSDNLEVVEFCKNHGILVEAYGPLTPLRNPNPKTDALIEKLQ 218
Cdd:cd19119 155 LDGRAKAIGVSNYSIVYLERLIKECkvVPAVNQVELHPHLPQMDLRDFCFKHGILVTAYSPLGSHGAPNLKNPLVKKIAE 234
|
250 260 270
....*....|....*....|....*....|...
gi 68482081 219 NANhLTKSQALFRYLLDNNILPITTSFKKERLK 251
Cdd:cd19119 235 KYN-VSTGDILISYHVRQGVIVLPKSLKPVRIV 266
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
12-252 |
1.53e-34 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 124.79 E-value: 1.53e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 12 TIGIGTGTSIKDLKRGQPTAENkARIVDILRYALSIGYNHIDTAEVYTTQPEVGTAI--AGFQREKLWITTKysVTSSMI 89
Cdd:cd19131 1 TITLNDGNTIPQLGLGVWQVSN-DEAASAVREALEVGYRSIDTAAIYGNEEGVGKAIraSGVPREELFITTK--LWNSDQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 90 KKKSftPTDFVEQALDEMNTNYIDLLLIHFPPKPNDPYTiqSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLL-EIG-TP 167
Cdd:cd19131 78 GYDS--TLRAFDESLRKLGLDYVDLYLIHWPVPAQDKYV--ETWKALIELKKEGRVKSIGVSNFTIEHLQRLIdETGvVP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 168 TINQIQYYLGSDNLEVVEFCKNHGILVEAYGPL---TPLRNPnpktdaLIEKLQNANHLTKSQALFRYLLDNNILPITTS 244
Cdd:cd19131 154 VVNQIELHPRFQQRELRAFHAKHGIQTESWSPLgqgGLLSDP------VIGEIAEKHGKTPAQVVIRWHLQNGLVVIPKS 227
|
....*...
gi 68482081 245 FKKERLKE 252
Cdd:cd19131 228 VTPSRIAE 235
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
44-258 |
4.78e-34 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 124.06 E-value: 4.78e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 44 ALSIGYNHIDTAEVYTTQPEVGTAIA-------GFQREKLWITTKysvtssmIKKKSFTPTDfVEQALD----EMNTNYI 112
Cdd:cd19118 29 ALKAGYRHLDLAKVYQNQHEVGQALKellkeepGVKREDLFITSK-------LWNNSHRPEY-VEPALDdtlkELGLDYL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 113 DLLLIHFP-------------PKPNDP--------YTIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIG--TPTI 169
Cdd:cd19118 101 DLYLIHWPvafkptgdlnpltAVPTNGgevdldlsVSLVDTWKAMVELKKTGKVKSIGVSNFSIDHLQAIIEETgvVPAV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 170 NQIQYYLGSDNLEVVEFCKNHGILVEAYGPL------TPLRNPNPKTDALIEKLqnaNHlTKSQALFRYLLDNNILPITT 243
Cdd:cd19118 181 NQIEAHPLLLQDELVDYCKSKNIHITAYSPLgnnlagLPLLVQHPEVKAIAAKL---GK-TPAQVLIAWGIQRGHSVIPK 256
|
250
....*....|....*
gi 68482081 244 SFKKERLKEALHSYT 258
Cdd:cd19118 257 SVTPSRIRSNFEQVE 271
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
13-252 |
7.95e-34 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 123.58 E-value: 7.95e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 13 IGIGTGTSikdlkRGQPTAENKARIVDILRYALSIGYNHIDTAEVY---TTQPEVGTAIAG--FQREKLWITTKYSVTSS 87
Cdd:pfam00248 1 IGLGTWQL-----GGGWGPISKEEALEALRAALEAGINFIDTAEVYgdgKSEELLGEALKDypVKRDKVVIATKVPDGDG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 88 MIkKKSFTP---TDFVEQALDEMNTNYIDLLLIHFPpkpnDPYT-IQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLE 163
Cdd:pfam00248 76 PW-PSGGSKeniRKSLEESLKRLGTDYIDLYYLHWP----DPDTpIEETWDALEELKKEGKIRAIGVSNFDAEQIEKALT 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 164 IG--TPTINQIQY--YLGSDNLEVVEFCKNHGILVEAYGPL---------TPLRNPNP---------------KTDALIE 215
Cdd:pfam00248 151 KGkiPIVAVQVEYnlLRRRQEEELLEYCKKNGIPLIAYSPLggglltgkyTRDPDKGPgerrrllkkgtplnlEALEALE 230
|
250 260 270
....*....|....*....|....*....|....*....
gi 68482081 216 KLQNANHLTKSQALFRYLL--DNNILPITTSFKKERLKE 252
Cdd:pfam00248 231 EIAKEHGVSPAQVALRWALskPGVTIPIPGASNPEQLED 269
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
44-252 |
1.05e-33 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 122.30 E-value: 1.05e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 44 ALSIGYNHIDTAEVYTTQPEVGTAI--AGFQREKLWITTKYSVTSSMIK--KKSFtptdfvEQALDEMNTNYIDLLLIHF 119
Cdd:cd19133 32 AIKAGYRLIDTAAAYGNEEAVGRAIkkSGIPREELFITTKLWIQDAGYEkaKKAF------ERSLKRLGLDYLDLYLIHQ 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 120 PpkPNDPYtiqSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIG--TPTINQIQYYLGSDNLEVVEFCKNHGILVEAY 197
Cdd:cd19133 106 P--FGDVY---GAWRAMEELYKEGKIRAIGVSNFYPDRLVDLILHNevKPAVNQIETHPFNQQIEAVEFLKKYGVQIEAW 180
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 68482081 198 GPLTPLRNpNPKTDALIEKLQNANHLTKSQALFRYLLDNNILPITTSFKKERLKE 252
Cdd:cd19133 181 GPFAEGRN-NLFENPVLTEIAEKYGKSVAQVILRWLIQRGIVVIPKSVRPERIAE 234
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
37-250 |
4.31e-33 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 121.28 E-value: 4.31e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 37 IVDILRYALSIGYNHIDTAEVYTTQPEVGTAIA--GFQREKLWITTKYSVtsSMIKKKSFTPTdfVEQALDEMNTNYIDL 114
Cdd:PRK11172 18 VIDSVKTALELGYRAIDTAQIYDNEAAVGQAIAesGVPRDELFITTKIWI--DNLAKDKLIPS--LKESLQKLRTDYVDL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 115 LLIHFpPKPNDPYTIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLE-IGTPTI--NQIQY--YLgsDNLEVVEFCKN 189
Cdd:PRK11172 94 TLIHW-PSPNDEVSVEEFMQALLEAKKQGLTREIGISNFTIALMKQAIAaVGAENIatNQIELspYL--QNRKVVAFAKE 170
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68482081 190 HGILVEAYGPLT---PLRNPnpktdaLIEKLQNANHLTKSQALFRYLLDNNILPITTSFKKERL 250
Cdd:PRK11172 171 HGIHVTSYMTLAygkVLKDP------VIARIAAKHNATPAQVILAWAMQLGYSVIPSSTKRENL 228
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
31-252 |
1.02e-32 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 120.32 E-value: 1.02e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 31 AENKARIVDILRYALSIGYNHIDTAEVYTTQPEVGTAIA--GFQREKLWITTKYSVTSSMIKKksfTPTDFvEQALDEMN 108
Cdd:cd19156 19 VQDGAEAENAVKWAIEAGYRHIDTAAIYKNEEGVGQGIResGVPREEVFVTTKLWNSDQGYES---TLAAF-EESLEKLG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 109 TNYIDLLLIHFPPKpnDPYtiQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIG--TPTINQIQYYLGSDNLEVVEF 186
Cdd:cd19156 95 LDYVDLYLIHWPVK--GKF--KDTWKAFEKLYKEKKVRAIGVSNFHEHHLEELLKSCkvAPMVNQIELHPLLTQEPLRKF 170
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 68482081 187 CKNHGILVEAYgplTPLRNPNPKTDALIEKLQNANHLTKSQALFRYLLDNNILPITTSFKKERLKE 252
Cdd:cd19156 171 CKEKNIAVEAW---SPLGQGKLLSNPVLKAIGKKYGKSAAQVIIRWDIQHGIITIPKSVHEERIQE 233
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
15-257 |
2.30e-32 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 119.68 E-value: 2.30e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 15 IGTGTSikdlkrgqPTAENKARIVDILRYALSIGYNHIDTAEVYTTQPEVGTAIA-----GF--QREKLWITTKYSVtss 87
Cdd:cd19124 8 IGMGTA--------SDPPSPEDIKAAVLEAIEVGYRHFDTAAAYGTEEALGEALAealrlGLvkSRDELFVTSKLWC--- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 88 mikkkSFTPTDFVEQALDE----MNTNYIDLLLIH-----------FPPKPND--PYTIQSLWQEFVSIKATGKVRYIGV 150
Cdd:cd19124 77 -----SDAHPDLVLPALKKslrnLQLEYVDLYLIHwpvslkpgkfsFPIEEEDflPFDIKGVWEAMEECQRLGLTKAIGV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 151 SNFDIPQLNTLLEIGT--PTINQIQYYLGSDNLEVVEFCKNHGILVEAYGPLTPLRNPNPKTDAL----IEKLQNANHLT 224
Cdd:cd19124 152 SNFSCKKLQELLSFATipPAVNQVEMNPAWQQKKLREFCKANGIHVTAYSPLGAPGTKWGSNAVMesdvLKEIAAAKGKT 231
|
250 260 270
....*....|....*....|....*....|...
gi 68482081 225 KSQALFRYLLDNNILPITTSFKKERLKEALHSY 257
Cdd:cd19124 232 VAQVSLRWVYEQGVSLVVKSFNKERMKQNLDIF 264
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
41-256 |
4.20e-32 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 119.44 E-value: 4.20e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 41 LRYALSIGYNHIDTAEVYTTQPEVGTAIA------GFQREKLWITTKysVTSSMIKKKSFTPTdfVEQALDEMNTNYIDL 114
Cdd:cd19123 31 VKQALEAGYRHIDCAAIYGNEAEIGAALAevfkegKVKREDLWITSK--LWNNSHAPEDVLPA--LEKTLADLQLDYLDL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 115 LLIH----------FPPKPND-----PYTIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGT--PTINQIQY--Y 175
Cdd:cd19123 107 YLMHwpvalkkgvgFPESGEDllslsPIPLEDTWRAMEELVDKGLCRHIGVSNFSVKKLEDLLATARikPAVNQVELhpY 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 176 LGSDNLevVEFCKNHGILVEAYGPL-TPLRNPNPK--------TDALIEKLQNANHLTKSQALFRYLLDNNILPITTSFK 246
Cdd:cd19123 187 LQQPEL--LAFCRDNGIHLTAYSPLgSGDRPAAMKaegepvllEDPVINKIAEKHGASPAQVLIAWAIQRGTVVIPKSVN 264
|
250
....*....|
gi 68482081 247 KERLKEALHS 256
Cdd:cd19123 265 PERIQQNLEA 274
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
38-254 |
4.51e-32 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 118.66 E-value: 4.51e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 38 VDILRYALSIGYNHIDTAEVYTTQPEVGTAI--AGFQREKLWITTKYSVTSSMIKK--KSFtptdfvEQALDEMNTNYID 113
Cdd:cd19127 25 ADAVATALADGYRLIDTAAAYGNEREVGEGIrrSGVDRSDIFVTTKLWISDYGYDKalRGF------DASLRRLGLDYVD 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 114 LLLIHFPPKPNDPYTIQSlWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGT--PTINQIQYYLGSDNLEVVEFCKNHG 191
Cdd:cd19127 99 LYLLHWPVPNDFDRTIQA-YKALEKLLAEGRVRAIGVSNFTPEHLERLIDATTvvPAVNQVELHPYFSQKDLRAFHRRLG 177
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 68482081 192 ILVEAYGPL---------TPLRNPNPKTDALIEKLQNANHLTKSQALFRYLLDNNILPITTSFKKERLKEAL 254
Cdd:cd19127 178 IVTQAWSPIggvmrygasGPTGPGDVLQDPTITGLAEKYGKTPAQIVLRWHLQNGVSAIPKSVHPERIAENI 249
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
43-254 |
3.13e-31 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 116.48 E-value: 3.13e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 43 YALSIGYNHIDTAEVYTTQPEVGTAI-----AGFQREKLWITTKysVTSSMIKKksftPTDFVEQALDEMNTNYIDLLLI 117
Cdd:cd19121 33 HALKIGYRHIDGALCYQNEDEVGEGIkeaiaGGVKREDLFVTTK--LWSTYHRR----VELCLDRSLKSLGLDYVDLYLV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 118 HFP----PKPNDP---------------YTIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGT--PTINQIQYYL 176
Cdd:cd19121 107 HWPvllnPNGNHDlfptlpdgsrdldwdWNHVDTWKQMEKVLKTGKTKAIGVSNYSIPYLEELLKHATvvPAVNQVENHP 186
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 68482081 177 GSDNLEVVEFCKNHGILVEAYGPLTPLRNPNPKTDALIEkLQNANHLTKSQALFRYLLDNNILPITTSFKKERLKEAL 254
Cdd:cd19121 187 YLPQQELVDFCKEKGILIEAYSPLGSTGSPLISDEPVVE-IAKKHNVGPGTVLISYQVARGAVVLPKSVTPDRIKSNL 263
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
38-200 |
1.43e-30 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 114.99 E-value: 1.43e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 38 VDILRYALSIGYNHIDTAEVY---TTQPEVGTAIAGfQREKLWITTKYSVtssmikkKSFTPTDF---VEQALDEMNTNY 111
Cdd:cd19085 26 IATIHAALDAGINFFDTAEAYgdgHSEEVLGKALKG-RRDDVVIATKVSP-------DNLTPEDVrksCERSLKRLGTDY 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 112 IDLLLIHFPPKPNDPY-TIQSLWQEfvsiKATGKVRYIGVSNFDIPQLNTLLEIGTPTINQIQYylgsdNL-------EV 183
Cdd:cd19085 98 IDLYQIHWPSSDVPLEeTMEALEKL----KEEGKIRAIGVSNFGPAQLEEALDAGRIDSNQLPY-----NLlwraieyEI 168
|
170
....*....|....*..
gi 68482081 184 VEFCKNHGILVEAYGPL 200
Cdd:cd19085 169 LPFCREHGIGVLAYSPL 185
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
6-254 |
1.71e-30 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 114.24 E-value: 1.71e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 6 VSGDPITI-GIGTGT-SIKDLKRGQPTAEnkarivdilryALSIGYNHIDTAEVYTTQPEVGTAIA--GFQREKLWITTK 81
Cdd:cd19130 3 VLNDGNSIpQLGYGVfKVPPADTQRAVAT-----------ALEVGYRHIDTAAIYGNEEGVGAAIAasGIPRDELFVTTK 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 82 YSVTssmiKKKSFTPTDFVEQALDEMNTNYIDLLLIHFPPKPNDPYTiqSLWQEFVSIKATGKVRYIGVSNFDIPQLNTL 161
Cdd:cd19130 72 LWND----RHDGDEPAAAFAESLAKLGLDQVDLYLVHWPTPAAGNYV--HTWEAMIELRAAGRTRSIGVSNFLPPHLERI 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 162 LEIG--TPTINQIQYYLGSDNLEVVEFCKNHGILVEAYGPL---TPLRNPnpktdaLIEKLQNANHLTKSQALFRYLLDN 236
Cdd:cd19130 146 VAATgvVPAVNQIELHPAYQQRTIRDWAQAHDVKIEAWSPLgqgKLLGDP------PVGAIAAAHGKTPAQIVLRWHLQK 219
|
250
....*....|....*...
gi 68482081 237 NILPITTSFKKERLKEAL 254
Cdd:cd19130 220 GHVVFPKSVRRERMEDNL 237
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
12-256 |
2.87e-30 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 113.88 E-value: 2.87e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 12 TIGIGTGTSIKDLkrGQPT---AENKARI---VDILRYALSIGYNHIDTAEVY---TTQPEVGTAIAGfQREKLWITTK- 81
Cdd:cd19138 2 TVTLPDGTKVPAL--GQGTwymGEDPAKRaqeIEALRAGIDLGMTLIDTAEMYgdgGSEELVGEAIRG-RRDKVFLVSKv 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 82 YSVTSS---MIKKksftptdfVEQALDEMNTNYIDLLLIHFPPKPNDPYTIQSlwqeFVSIKATGKVRYIGVSNFDIPQL 158
Cdd:cd19138 79 LPSNASrqgTVRA--------CERSLRRLGTDYLDLYLLHWRGGVPLAETVAA----MEELKKEGKIRAWGVSNFDTDDM 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 159 NTLLEI---GTPTINQIQYYLGSDNLE--VVEFCKNHGILVEAYGPLT---PLRNPNPKTDALIEkLQNANHLTKSQALF 230
Cdd:cd19138 147 EELWAVpggGNCAANQVLYNLGSRGIEydLLPWCREHGVPVMAYSPLAqggLLRRGLLENPTLKE-IAARHGATPAQVAL 225
|
250 260
....*....|....*....|....*..
gi 68482081 231 RYLL-DNNILPITTSFKKERLKEALHS 256
Cdd:cd19138 226 AWVLrDGNVIAIPKSGSPEHARENAAA 252
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
29-200 |
1.27e-29 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 112.96 E-value: 1.27e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 29 PTAENKARivDILRYALSIGYNHIDTAEVYTTQP-E--VGTAIAGFQREKLWITTK-YSVTSSMIKKKSFTP---TDFVE 101
Cdd:COG0667 29 GVDEAEAI--AILDAALDAGINFFDTADVYGPGRsEelLGEALKGRPRDDVVIATKvGRRMGPGPNGRGLSRehiRRAVE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 102 QALDEMNTNYIDLLLIHFPPkPNDPytIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGT----PTINQIQYylg 177
Cdd:COG0667 107 ASLRRLGTDYIDLYQLHRPD-PDTP--IEETLGALDELVREGKIRYIGVSNYSAEQLRRALAIAEglppIVAVQNEY--- 180
|
170 180 190
....*....|....*....|....*....|
gi 68482081 178 sdNL-------EVVEFCKNHGILVEAYGPL 200
Cdd:COG0667 181 --SLldrsaeeELLPAARELGVGVLAYSPL 208
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
38-200 |
2.41e-29 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 112.00 E-value: 2.41e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 38 VDILRYALSIGYNHIDTAEVY-TTQPE--VGTAIAGFqREKLWITTKYSVT-------SSMIKKKSFTPTdfVEQALDEM 107
Cdd:cd19102 29 IAAIRAALDLGINWIDTAAVYgLGHSEevVGRALKGL-RDRPIVATKCGLLwdeegriRRSLKPASIRAE--CEASLRRL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 108 NTNYIDLLLIHFPPKPNDpytIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGTPTINQIQYYL--GSDNLEVVE 185
Cdd:cd19102 106 GVDVIDLYQIHWPDPDEP---IEEAWGALAELKEEGKVRAIGVSNFSVDQMKRCQAIHPIASLQPPYSLlrRGIEAEILP 182
|
170
....*....|....*
gi 68482081 186 FCKNHGILVEAYGPL 200
Cdd:cd19102 183 FCAEHGIGVIVYSPM 197
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
37-254 |
1.40e-28 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 109.20 E-value: 1.40e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 37 IVDILRYALSIGYNHIDTAEVYT---TQPEVGTAIAGFQREKLWITTKysVTSSMIKKKSFTPTdfVEQALDEMNTNYID 113
Cdd:cd19137 28 MVELLKTAIELGYTHIDTAEMYGgghTEELVGKAIKDFPREDLFIVTK--VWPTNLRYDDLLRS--LQNSLRRLDTDYID 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 114 LLLIHFpPKPNDPY--TIQSLwQEFVsikATGKVRYIGVSNFDIPQLNTLLE-IGTPTI-NQIQYYLGSDNLE---VVEF 186
Cdd:cd19137 104 LYLIHW-PNPNIPLeeTLSAM-AEGV---RQGLIRYIGVSNFNRRLLEEAISkSQTPIVcNQVKYNLEDRDPErdgLLEY 178
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68482081 187 CKNHGILVEAYgplTPLRNPNPKTDALIEKLQNANHLTKSQALFRYLLDN-NILPITTSFKKERLKEAL 254
Cdd:cd19137 179 CQKNGITVVAY---SPLRRGLEKTNRTLEEIAKNYGKTIAQIALAWLIQKpNVVAIPKAGRVEHLKENL 244
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
12-252 |
8.13e-28 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 108.24 E-value: 8.13e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 12 TIGIGTGTSikdlKRGQptaenkarIVDILRYALSIGYNHIDTAEVYTTQPEVGTAI-------AGFQREKLWITTKYSV 84
Cdd:cd19106 9 LIGLGTWKS----KPGQ--------VKAAVKYALDAGYRHIDCAAVYGNEQEVGEALkekvgpgKAVPREDLFVTSKLWN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 85 TssmiKKKsftPTDF---VEQALDEMNTNYIDLLLIHFP--------PKPNDPY-TIQ-------SLWQEFVSIKATGKV 145
Cdd:cd19106 77 T----KHH---PEDVepaLRKTLKDLQLDYLDLYLIHWPyafergdnPFPKNPDgTIRydsthykETWKAMEKLVDKGLV 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 146 RYIGVSNFDIPQLNTLLEIGT--PTINQIQY--YLGSDNLevVEFCKNHGILVEAYGPL----TPLRNP-------NPKT 210
Cdd:cd19106 150 KAIGLSNFNSRQIDDILSVARikPAVLQVEChpYLAQNEL--IAHCKARGLVVTAYSPLgspdRPWAKPdepvlleEPKV 227
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 68482081 211 DALIEKLQNanhlTKSQALFRYLLDNNILPITTSFKKERLKE 252
Cdd:cd19106 228 KALAKKYNK----SPAQILLRWQVQRGVVVIPKSVTPSRIKQ 265
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
38-200 |
1.17e-27 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 107.61 E-value: 1.17e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 38 VDILRYALSIGYNHIDTAEVY---TTQPEVGTAIAGFqREKLWITTKYSVTS--SMIKKKSFTPtDFVEQALDE----MN 108
Cdd:cd19084 28 IEAIKAAIDLGINFFDTAPVYgfgHSEEILGKALKGR-RDDVVIATKCGLRWdgGKGVTKDLSP-ESIRKEVEQslrrLQ 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 109 TNYIDLLLIHFPpkpnDPYT-IQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGTPTINQIQYylgsdNL------ 181
Cdd:cd19084 106 TDYIDLYQIHWP----DPNTpIEETAEALEKLKKEGKIRYIGVSNFSVEQLEEARKYGPIVSLQPPY-----SMlereie 176
|
170 180
....*....|....*....|
gi 68482081 182 -EVVEFCKNHGILVEAYGPL 200
Cdd:cd19084 177 eELLPYCRENGIGVLPYGPL 196
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
44-254 |
1.48e-27 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 106.48 E-value: 1.48e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 44 ALSIGYNHIDTAEVYTTQPEVGTAIA--GFQREKLWITTKYSVTSsmikkKSFTPT-DFVEQALDEMNTNYIDLLLIHFP 120
Cdd:cd19134 33 ALEAGYRLIDTAAAYGNEAAVGRAIAasGIPRGELFVTTKLATPD-----QGFTASqAACRASLERLGLDYVDLYLIHWP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 121 PKPNDPYTiqSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIG--TPTINQIQYYLGSDNLEVVEFCKNHGILVEAYG 198
Cdd:cd19134 108 AGREGKYV--DSWGGLMKLREEGLARSIGVSNFTAEHLENLIDLTffTPAVNQIELHPLLNQAELRKVNAQHGIVTQAYS 185
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 68482081 199 PL---TPLRNPNpktdalIEKLQNANHLTKSQALFRYLLDNNILPITTSFKKERLKEAL 254
Cdd:cd19134 186 PLgvgRLLDNPA------VTAIAAAHGRTPAQVLLRWSLQLGNVVISRSSNPERIASNL 238
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
34-254 |
9.99e-27 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 105.00 E-value: 9.99e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 34 KARIVDILRYALSIGYNHIDTAEVYTTQPEVGTAI-----AG-FQREKLWITTKYSVTssmikkkSFTPtDFV----EQA 103
Cdd:cd19108 26 KSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIrskiaDGtVKREDIFYTSKLWCT-------FHRP-ELVrpalEKS 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 104 LDEMNTNYIDLLLIHFP----------PKPN------DPYTIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLL-EIG- 165
Cdd:cd19108 98 LKKLQLDYVDLYLIHFPvalkpgeelfPKDEngklifDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILnKPGl 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 166 --TPTINQI--QYYLGSDNLevVEFCKNHGILVEAYGPLTPLRNP---NPKTDALIE-----KLQNANHLTKSQALFRYL 233
Cdd:cd19108 178 kyKPVCNQVecHPYLNQSKL--LDFCKSKDIVLVAYSALGSQRDKewvDQNSPVLLEdpvlcALAKKHKRTPALIALRYQ 255
|
250 260
....*....|....*....|.
gi 68482081 234 LDNNILPITTSFKKERLKEAL 254
Cdd:cd19108 256 LQRGVVVLAKSFNEKRIKENL 276
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
44-252 |
1.11e-26 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 104.38 E-value: 1.11e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 44 ALSIGYNHIDTAEVYTTQPEVGTAI--AGFQREKLWITTKysvtssMIKKKSFTPTDFVEQALDEMNTNYIDLLLIHFPP 121
Cdd:PRK11565 37 ALEVGYRSIDTAAIYKNEEGVGKALkeASVAREELFITTK------LWNDDHKRPREALEESLKKLQLDYVDLYLMHWPV 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 122 KPNDPYTiqSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLL-EIG-TPTINQIQYYLGSDNLEVVEFCKNHGILVEAYGP 199
Cdd:PRK11565 111 PAIDHYV--EAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIdETGvTPVINQIELHPLMQQRQLHAWNATHKIQTESWSP 188
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 68482081 200 LTP-----LRNPnpktdaLIEKLQNANHLTKSQALFRYLLDNNILPITTSFKKERLKE 252
Cdd:PRK11565 189 LAQggkgvFDQK------VIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAE 240
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
13-200 |
5.81e-26 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 101.44 E-value: 5.81e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 13 IGIGTGTsikdlkRGQPTAENKARivDILRYALSIGYNHIDTAEVY---TTQPEVGTAIAGFQ-REKLWITTK--YSVTS 86
Cdd:cd06660 3 LGLGTMT------FGGDGDEEEAF--ALLDAALEAGGNFFDTADVYgdgRSERLLGRWLKGRGnRDDVVIATKggHPPGG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 87 SMiKKKSFTPTDF---VEQALDEMNTNYIDLLLIHFPPkPNDPytIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLE 163
Cdd:cd06660 75 DP-SRSRLSPEHIrrdLEESLRRLGTDYIDLYYLHRDD-PSTP--VEETLEALNELVREGKIRYIGVSNWSAERLAEALA 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 68482081 164 IGT------PTINQIQYYLGS---DNLEVVEFCKNHGILVEAYGPL 200
Cdd:cd06660 151 YAKahglpgFAAVQPQYSLLDrspMEEELLDWAEENGLPLLAYSPL 196
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
33-252 |
2.46e-25 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 101.41 E-value: 2.46e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 33 NKARIVDILRYALSIGYNHIDTAEVYTTQPEVGTAIA-GFQ-----REKLWITTKYSVTSSMIKKKSftptdfVEQALDE 106
Cdd:cd19112 22 EPGEIKELILNAIKIGYRHFDCAADYKNEKEVGEALAeAFKtglvkREDLFITTKLWNSDHGHVIEA------CKDSLKK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 107 MNTNYIDLLLIHFP--------PKPNDPYTIQSLWQEFVSIK------------ATGKVRYIGVSNFDIPQLNTLLEIG- 165
Cdd:cd19112 96 LQLDYLDLYLVHFPvatkhtgvGTTGSALGEDGVLDIDVTISlettwhameklvSAGLVRSIGISNYDIFLTRDCLAYSk 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 166 -TPTINQIQY--YLGSDNLevVEFCKNHGILVEAYGPL-------------TPLRNPnpktdaLIEKLQNANHLTKSQAL 229
Cdd:cd19112 176 iKPAVNQIEThpYFQRDSL--VKFCQKHGISVTAHTPLggaaanaewfgsvSPLDDP------VLKDLAKKYGKSAAQIV 247
|
250 260
....*....|....*....|...
gi 68482081 230 FRYLLDNNILPITTSFKKERLKE 252
Cdd:cd19112 248 LRWGIQRNTAVIPKSSKPERLKE 270
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
38-252 |
7.38e-25 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 98.81 E-value: 7.38e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 38 VDILRYALSIGYNHIDTAEVYTTQPE---VGTAIAGFQREKLWITTKYSVTSSMIKKKSFTPTdfVEQALDEMNTNYIDL 114
Cdd:cd19105 28 PELLRRALDLGINYFDTAEGYGNGNSeeiIGEALKGLRRDKVFLATKASPRLDKKDKAELLKS--VEESLKRLQTDYIDI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 115 LLIHFPPKPNDPYTIQSLWQEFVSIKATGKVRYIGVS--NFDIPQLNTLLEIG-----TPTINQIQYYLGSDnlEVVEFC 187
Cdd:cd19105 106 YQLHGVDTPEERLLNEELLEALEKLKKEGKVRFIGFSthDNMAEVLQAAIESGwfdviMVAYNFLNQPAELE--EALAAA 183
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 68482081 188 KNHGILVEAYGPLTPLRNpNPKTDALIEKLQnanhLTKSQALFRYLLDNN----ILPITTSFkkERLKE 252
Cdd:cd19105 184 AEKGIGVVAMKTLAGGYL-QPALLSVLKAKG----FSLPQAALKWVLSNPrvdtVVPGMRNF--AELEE 245
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
15-252 |
1.09e-24 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 99.45 E-value: 1.09e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 15 IGTGTSIKDlkrgqPTAENKArivdiLRYALSIGYNHIDTAEVYTTQPEVGTAI-----AG-FQREKLWITTKYSVTSSm 88
Cdd:cd19129 9 LGFGTLIPD-----PSATRNA-----VKAALEAGFRHFDCAERYRNEAEVGEAMqevfkAGkIRREDLFVTTKLWNTNH- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 89 iKKKSFTPTdfVEQALDEMNTNYIDLLLIH----FPPKPN-DP------------YTIQSLWQEFVSIKATGKVRYIGVS 151
Cdd:cd19129 78 -RPERVKPA--FEASLKRLQLDYLDLYLIHtpfaFQPGDEqDPrdangnviyddgVTLLDTWRAMERLVDEGRCKAIGLS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 152 NFDIPQLNTLLEIGT--PTINQIQYYLGSDNLEVVEFCKNHGILVEAYGPLTPLRNPNPKTDALIEKLQNANHLTKSQAL 229
Cdd:cd19129 155 DVSLEKLREIFEAARikPAVVQVESHPYLPEWELLDFCKNHGIVLQAFAPLGHGMEPKLLEDPVITAIARRVNKTPAQVL 234
|
250 260
....*....|....*....|...
gi 68482081 230 FRYLLDNNILPITTSFKKERLKE 252
Cdd:cd19129 235 LAWAIQRGTALLTTSKTPSRIRE 257
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
4-200 |
1.89e-24 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 99.27 E-value: 1.89e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 4 TTVSGDPITIG---IGTGTSIKDLKrgqptaENKAriVDILRYALSIGYNHIDTAEVYTT-QPE--VGTAIAGFqREKLW 77
Cdd:cd19149 7 SGIEASVIGLGtwaIGGGPWWGGSD------DNES--IRTIHAALDLGINLIDTAPAYGFgHSEeiVGKAIKGR-RDKVV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 78 ITTKYSV------TSSMIKKKSFT------PT---DFVEQALDEMNTNYIDLLLIHFPpkpnDPYT-IQSLWQEFVSIKA 141
Cdd:cd19149 78 LATKCGLrwdregGSFFFVRDGVTvyknlsPEsirEEVEQSLKRLGTDYIDLYQTHWQ----DVETpIEETMEALEELKR 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 68482081 142 TGKVRYIGVSNFDIPQLNTLLEIGTPTINQIQYYLGSDNLE--VVEFCKNHGILVEAYGPL 200
Cdd:cd19149 154 QGKIRAIGASNVSVEQIKEYVKAGQLDIIQEKYSMLDRGIEkeLLPYCKKNNIAFQAYSPL 214
|
|
| YdhF |
COG4989 |
Predicted oxidoreductase YdhF [General function prediction only]; |
33-253 |
3.10e-24 |
|
Predicted oxidoreductase YdhF [General function prediction only];
Pssm-ID: 444013 [Multi-domain] Cd Length: 299 Bit Score: 98.30 E-value: 3.10e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 33 NKARIVDILRYALSIGYNHIDTAEVY---TTQPEVGTAIA--GFQREKLWITTK----YSVTSSMIKKKSFtptDF---- 99
Cdd:COG4989 29 SPAEAAALIEAALELGITTFDHADIYggyTCEALFGEALKlsPSLREKIELQTKcgirLPSEARDNRVKHY---DTskeh 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 100 ----VEQALDEMNTNYIDLLLIHFPpkpnDPYT-IQSLWQEFVSIKATGKVRYIGVSNFDIPQLnTLLE--IGTP-TINQ 171
Cdd:COG4989 106 iiasVEGSLRRLGTDYLDLLLLHRP----DPLMdPEEVAEAFDELKASGKVRHFGVSNFTPSQF-ELLQsaLDQPlVTNQ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 172 IQYYLG-SDNLE--VVEFCKNHGILVEAYGPL------TPLRNPNPKTDALIEKLQNANHLTKSQALFRYLLDN--NILP 240
Cdd:COG4989 181 IELSLLhTDAFDdgTLDYCQLNGITPMAWSPLaggrlfGGFDEQFPRLRAALDELAEKYGVSPEAIALAWLLRHpaGIQP 260
|
250
....*....|...
gi 68482081 241 ITTSFKKERLKEA 253
Cdd:COG4989 261 VIGTTNPERIKAA 273
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
14-200 |
4.54e-24 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 97.69 E-value: 4.54e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 14 GIGTGTSIKDLKRGQPTAEnkarivdiLRYALSIGYNHIDTAEVYTTQPEVGTAIAGF-------QREKLWITTKysvts 86
Cdd:cd19122 11 AVGFGTFANEGAKGETYAA--------VTKALDVGYRHLDCAWFYLNEDEVGDAVRDFlkenpsvKREDLFICTK----- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 87 smIKKKSFTPTDF---VEQALDEMNTNYIDLLLIHFP----------PK--PNDPYTI--------QSLWQEFVSIKATG 143
Cdd:cd19122 78 --VWNHLHEPEDVkwsIDNSLKNLKLDYIDLFLVHWPiaaekndqrsPKlgPDGKYVIlkdltenpEPTWRAMEEIYESG 155
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 68482081 144 KVRYIGVSNFDIPQLNTLLEIGT--PTINQIQYYLGSDNLEVVEFCKNHGILVEAYGPL 200
Cdd:cd19122 156 KAKAIGVSNWTIPGLKKLLSFAKvkPHVNQIEIHPFLPNEELVDYCFSNDILPEAYSPL 214
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
44-259 |
7.50e-24 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 97.60 E-value: 7.50e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 44 ALSIGYNHIDTAEVYTTQPEVGTAI-----AG-FQREKLWITTKYSvtssMIKKKSFTPTDFVEQALDEMNTNYIDLLLI 117
Cdd:cd19155 34 ALEAGYRHIDTAYVYRNEAAIGNVLkkwidSGkVKREELFIVTKLP----PGGNRREKVEKFLLKSLEKLQLDYVDLYLI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 118 HFPPKPN-----------------DPYT-IQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGT--PTINQIQYYLG 177
Cdd:cd19155 110 HFPVGSLskeddsgkldptgehkqDYTTdLLDIWKAMEAQVDQGLTRSIGLSNFNREQMARILKNARikPANLQVELHVY 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 178 SDNLEVVEFCKNHGILVEAYGPL-TPLRN-------------PNPKTDALIEKLQNANHLTKSQALFRYLLDNNILPITT 243
Cdd:cd19155 190 LQQKDLVDFCSTHSITVTAYAPLgSPGAAhfspgtgspsgssPDLLQDPVVKAIAERHGKSPAQVLLRWLMQRGVVVIPK 269
|
250
....*....|....*.
gi 68482081 244 SFKKERLKEALHSYTY 259
Cdd:cd19155 270 STNAARIKENFQVFDF 285
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
10-252 |
1.19e-23 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 97.10 E-value: 1.19e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 10 PItIGIGTGTSikdlKRGQPTAENKArivdilryALSIGYNHIDTAEVYTTQPEVGTAI------AGFQREKLWITTKYS 83
Cdd:cd19107 5 PI-LGLGTWKS----PPGQVTEAVKV--------AIDAGYRHIDCAYVYQNENEVGEAIqekikeQVVKREDLFIVSKLW 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 84 VT---SSMIKKKsftptdfVEQALDEMNTNYIDLLLIHFP----------PKPNDPYTIQS------LWQEFVSIKATGK 144
Cdd:cd19107 72 CTfheKGLVKGA-------CQKTLSDLKLDYLDLYLIHWPtgfkpgkelfPLDESGNVIPSdttfldTWEAMEELVDEGL 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 145 VRYIGVSNFDIPQLNTLLEIG----TPTINQIQY--YLGSDNLevVEFCKNHGILVEAYGPL-TPLR------NPNPKTD 211
Cdd:cd19107 145 VKAIGVSNFNHLQIERILNKPglkyKPAVNQIEChpYLTQEKL--IQYCQSKGIVVTAYSPLgSPDRpwakpeDPSLLED 222
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 68482081 212 ALIEKLQNANHLTKSQALFRYLLDNNILPITTSFKKERLKE 252
Cdd:cd19107 223 PKIKEIAAKHNKTTAQVLIRFPIQRNLVVIPKSVTPERIAE 263
|
|
| AKR_AKR1E1-2 |
cd19110 |
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ... |
36-259 |
1.25e-23 |
|
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 96.95 E-value: 1.25e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 36 RIVDILRYALSIGYNHIDTAEVYTTQPEVGTAIAG------FQREKLWITTKYSVTSsmiKKKSFTPTDfVEQALDEMNT 109
Cdd:cd19110 18 EVTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIREkikegvVRREDLFIVSKLWCTC---HKKSLVKTA-CTRSLKALKL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 110 NYIDLLLIHF-----PPKPNDPYTIQSL-----------WQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIG----TPTI 169
Cdd:cd19110 94 NYLDLYLIHWpmgfkPGEPDLPLDRSGMvipsdtdfldtWEAMEDLVIEGLVKNIGVSNFNHEQLERLLNKPglrvKPVT 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 170 NQIQY--YLGSDNLevVEFCKNHGILVEAYGPL------TPLRNpnpktDALIEKLQNANHLTKSQALFRYLLDNNILPI 241
Cdd:cd19110 174 NQIEChpYLTQKKL--ISFCQSRNVSVTAYRPLggscegVDLID-----DPVIQRIAKKHGKSPAQILIRFQIQRNVIVI 246
|
250
....*....|....*...
gi 68482081 242 TTSFKKERLKEALHSYTY 259
Cdd:cd19110 247 PKSVTPSRIKENIQVFDF 264
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
35-254 |
1.49e-23 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 96.47 E-value: 1.49e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 35 ARIVDILRYALSIGYNHIDTAEVYT-TQPE--VGTAIA--GFQREKLWITTK----YSVTSSMIKKKSFtptDF------ 99
Cdd:cd19092 24 EELLSLIEAALELGITTFDHADIYGgGKCEelFGEALAlnPGLREKIEIQTKcgirLGDDPRPGRIKHY---DTskehil 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 100 --VEQALDEMNTNYIDLLLIHFPpkpnDPYT-IQSLWQEFVSIKATGKVRYIGVSNFDIPQ---LNTLLEIgtP-TINQI 172
Cdd:cd19092 101 asVEGSLKRLGTDYLDLLLLHRP----DPLMdPEEVAEAFDELVKSGKVRYFGVSNFTPSQielLQSYLDQ--PlVTNQI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 173 QYYLG-SDNLE--VVEFCKNHGILVEAYGPL------TPLRNPNPKTDALIEKLQNANHLTKSQALFRYLLDN--NILPI 241
Cdd:cd19092 175 ELSLLhTEAIDdgTLDYCQLLDITPMAWSPLgggrlfGGFDERFQRLRAALEELAEEYGVTIEAIALAWLLRHpaRIQPI 254
|
250
....*....|...
gi 68482081 242 TTSFKKERLKEAL 254
Cdd:cd19092 255 LGTTNPERIRSAV 267
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
33-236 |
5.75e-23 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 96.04 E-value: 5.75e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 33 NKARIVDILRYALSIGYNHIDTAEVYTT-QPEVGTAIAGfQREKLWITTKysvtsSMIKKKsfTPTDF---VEQALDEMN 108
Cdd:COG1453 27 DEEEAEALIRRAIDNGINYIDTARGYGDsEEFLGKALKG-PRDKVILATK-----LPPWVR--DPEDMrkdLEESLKRLQ 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 109 TNYIDLLLIHFPPKPND-PYTIQS--LWQEFVSIKATGKVRYIGVSNFDIPQLntLLEIgtptIN-------QIQY-YLG 177
Cdd:COG1453 99 TDYIDLYLIHGLNTEEDlEKVLKPggALEALEKAKAEGKIRHIGFSTHGSLEV--IKEA----IDtgdfdfvQLQYnYLD 172
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 178 SDN---LEVVEFCKNHGIlveaygPLT---PLR-----NPNPKTDALIEKlqnanHLTKSQALFRYLLDN 236
Cdd:COG1453 173 QDNqagEEALEAAAEKGI------GVIimkPLKggrlaNPPEKLVELLCP-----PLSPAEWALRFLLSH 231
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
13-194 |
1.12e-22 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 92.93 E-value: 1.12e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 13 IGIGTGTsikdlkRGQPTAEnkaRIVDILRYALSIGYNHIDTAEVY-TTQPEVGTAIAGFqREKLWITTK-YSVTSSMIK 90
Cdd:cd19100 14 LGFGGGP------LGRLSQE---EAAAIIRRALDLGINYFDTAPSYgDSEEKIGKALKGR-RDKVFLATKtGARDYEGAK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 91 KKsftptdfVEQALDEMNTNYIDLLLIHFPPKPNDPYTIQS---LWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIG-- 165
Cdd:cd19100 84 RD-------LERSLKRLGTDYIDLYQLHAVDTEEDLDQVFGpggALEALLEAKEEGKIRFIGISGHSPEVLLRALETGef 156
|
170 180 190
....*....|....*....|....*....|..
gi 68482081 166 ---TPTINQIQYYLGSDNLEVVEFCKNHGILV 194
Cdd:cd19100 157 dvvLFPINPAGDHIDSFREELLPLAREKGVGV 188
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
41-258 |
1.74e-22 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 93.36 E-value: 1.74e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 41 LRYALSIGYNHIDTAEVYTTQPEVGTAIA------GFQREKLWITTKysvtssmIKKKSFTPTDFVEQ---ALDEMNTNY 111
Cdd:cd19128 20 VKNAIKAGYRHIDCAYYYGNEAFIGIAFSeifkdgGVKREDLFITSK-------LWPTMHQPENVKEQlliTLQDLQLEY 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 112 IDLLLIHFPP--KPNDP--------------YTIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGT--PTINQIQ 173
Cdd:cd19128 93 LDLFLIHWPLafDMDTDgdprddnqiqslskKPLEDTWRAMEQCVDEKLTKNIGVSNYSTKLLTDLLNYCKikPFMNQIE 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 174 YYLGSDNLEVVEFCKNHGILVEAYGPL-TPLRNPN--PKTDALIEKLQNANHLTKSQALFRYLLD---NNILPITTSFKK 247
Cdd:cd19128 173 CHPYFQNDKLIKFCIENNIHVTAYRPLgGSYGDGNltFLNDSELKALATKYNTTPPQVIIAWHLQkwpKNYSVIPKSANK 252
|
250
....*....|.
gi 68482081 248 ERLKEALHSYT 258
Cdd:cd19128 253 SRCQQNFDIND 263
|
|
| AKR_AKR1D1-3 |
cd19109 |
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ... |
10-252 |
4.18e-22 |
|
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.
Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 92.94 E-value: 4.18e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 10 PItIGIGTGTSIKdlkrgQPTAENKARIVDIlryALSIGYNHIDTAEVYTTQPEVGTAI------AGFQRE------KLW 77
Cdd:cd19109 5 PI-IGLGTYSEPK-----TTPKGACAEAVKV---AIDTGYRHIDGAYIYQNEHEVGQAIrekiaeGKVKREdifycgKLW 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 78 ITTKysvTSSMIKkksftPTdfVEQALDEMNTNYIDLLLIHFPP--KPNDPY--------------TIQSLWQEFVSIKA 141
Cdd:cd19109 76 NTCH---PPELVR-----PT--LERTLKVLQLDYVDLYIIEMPMafKPGDEIyprdengkwlyhktNLCATWEALEACKD 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 142 TGKVRYIGVSNFDIPQLNTLLEIG----TPTINQIQYYLGSDNLEVVEFCKNHGILVEAYGPLTPLRNP---NPKT---- 210
Cdd:cd19109 146 AGLVKSIGVSNFNRRQLELILNKPglkhKPVSNQVECHPYFTQPKLLEFCQQHDIVIVAYSPLGTCRDPiwvNVSSppll 225
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 68482081 211 -DALIEKLQNANHLTKSQALFRYLLDNNILPITTSFKKERLKE 252
Cdd:cd19109 226 eDPLLNSIGKKYNKTAAQVVLRFNIQRGVVVIPKSFNPERIKE 268
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
13-254 |
2.43e-21 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 89.60 E-value: 2.43e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 13 IGIGTGtSIkdlkRGQPTAENKARIVDILRYALSIGYNHIDTAEVY-TTQPEVGTAIAGFQREKLWITTKYSVTSSMIKK 91
Cdd:cd19095 3 LGLGTS-GI----GRVWGVPSEAEAARLLNTALDLGINLIDTAPAYgRSEERLGRALAGLRRDDLFIATKVGTHGEGGRD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 92 -KSFTP---TDFVEQALDEMNTNYIDLLLIHFPPKPNDPYTIQSLWQEFvsiKATGKVRYIGVSNFDiPQLNTLLEIGTP 167
Cdd:cd19095 78 rKDFSPaaiRASIERSLRRLGTDYIDLLQLHGPSDDELTGEVLETLEDL---KAAGKVRYIGVSGDG-EELEAAIASGVF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 168 TINQIQYYLGS-DNLEVVEFCKNHGILVEAYGPL--------TPLRNPNPKTDALIEKLQNANHLTKSQALFRYLLDN-- 236
Cdd:cd19095 154 DVVQLPYNVLDrEEEELLPLAAEAGLGVIVNRPLangrlrrrVRRRPLYADYARRPEFAAEIGGATWAQAALRFVLSHpg 233
|
250 260
....*....|....*....|
gi 68482081 237 --NILPITTsfKKERLKEAL 254
Cdd:cd19095 234 vsSAIVGTT--NPEHLEENL 251
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
13-254 |
4.35e-21 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 89.59 E-value: 4.35e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 13 IGIGTgTSIKDLKRGQPTAENKARIVDILRYALSIGYNHIDTAEVY-TTQPE--VGTAIAGFQ-REKLWITTKYSVTSSm 88
Cdd:cd19093 5 LGLGT-WQWGDRLWWGYGEYGDEDLQAAFDAALEAGVNLFDTAEVYgTGRSErlLGRFLKELGdRDEVVIATKFAPLPW- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 89 ikkkSFTPTDFV---EQALDEMNTNYIDLLLIHFPPKPNDPytIQSLWQEFVSIKATGKVRYIGVSNFDIPQL----NTL 161
Cdd:cd19093 83 ----RLTRRSVVkalKASLERLGLDSIDLYQLHWPGPWYSQ--IEALMDGLADAVEEGLVRAVGVSNYSADQLrrahKAL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 162 LEIGTPTI-NQIQYYL---GSDNLEVVEFCKNHGILVEAYGPL---------TPLRNPN------------PKTDALIEK 216
Cdd:cd19093 157 KERGVPLAsNQVEYSLlyrDPEQNGLLPACDELGITLIAYSPLaqglltgkySPENPPPggrrrlfgrknlEKVQPLLDA 236
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 68482081 217 L-QNANHL--TKSQALFRYLLDNNILPITTSFKKERLKEAL 254
Cdd:cd19093 237 LeEIAEKYgkTPAQVALNWLIAKGVVPIPGAKNAEQAEENA 277
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
33-200 |
1.17e-20 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 89.02 E-value: 1.17e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 33 NKARIVDILRYALSIGYNHIDTAEVYTT---QPEVGTAIAGFQREKLWITTK----YSVTSSMIKKKSFTPTDFVEQALD 105
Cdd:cd19083 31 DEEEGKDLVREALDNGVNLLDTAFIYGLgrsEELVGEVLKEYNRNEVVIATKgahkFGGDGSVLNNSPEFLRSAVEKSLK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 106 EMNTNYIDLLLIHFP----PKPNDPYTIQSLwqefvsiKATGKVRYIGVSNFDIPQLNTLLEIGTPTINQIQY-YLGSDN 180
Cdd:cd19083 111 RLNTDYIDLYYIHFPdgetPKAEAVGALQEL-------KDEGKIRAIGVSNFSLEQLKEANKDGYVDVLQGEYnLLQREA 183
|
170 180
....*....|....*....|.
gi 68482081 181 LE-VVEFCKNHGILVEAYGPL 200
Cdd:cd19083 184 EEdILPYCVENNISFIPYFPL 204
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
38-257 |
2.83e-19 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 84.15 E-value: 2.83e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 38 VDILRYALSIGYNHIDTAEVY-TTQPE--VGTAIAGFQREKLWITTKYSVTSSMikkksfTPTDF---VEQALDEMNTNY 111
Cdd:cd19096 24 IEMIRYAIDAGINYFDTAYGYgGGKSEeiLGEALKEGPREKFYLATKLPPWSVK------SAEDFrriLEESLKRLGVDY 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 112 IDLLLIHFPPKPNDPYTIQS--LWQEFVSIKATGKVRYIGVSNFDIPQ-LNTLLEIGTPTINQIQY-YLGSD---NLEVV 184
Cdd:cd19096 98 IDFYLLHGLNSPEWLEKARKggLLEFLEKAKKEGLIRHIGFSFHDSPElLKEILDSYDFDFVQLQYnYLDQEnqaGRPGI 177
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 68482081 185 EFCKNHGILVEAYGPL---TPLRNPNPKTDALIEKlqnanHLTKSQALFRYLLDN-NILPITTSF-KKERLKEALHSY 257
Cdd:cd19096 178 EYAAKKGMGVIIMEPLkggGLANNPPEALAILCGA-----PLSPAEWALRFLLSHpEVTTVLSGMsTPEQLDENIAAA 250
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
44-255 |
4.74e-19 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 84.42 E-value: 4.74e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 44 ALSIGYNHIDTAEVYTTQPEVGTAIAG------FQREKLWITTKYSvtssmikkKSFTPTDFVEQALD----EMNTNYID 113
Cdd:cd19113 33 AIKAGYRLFDGAEDYGNEKEVGEGVNRaideglVKREELFLTSKLW--------NNFHDPKNVETALNktlsDLKLDYVD 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 114 LLLIHFP----PKP-------------NDPYTIQSL-----WQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGT--PTI 169
Cdd:cd19113 105 LFLIHFPiafkFVPieekyppgfycgdGDNFVYEDVpildtWKALEKLVDAGKIKSIGVSNFPGALILDLLRGATikPAV 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 170 NQIQY--YLGSDNLevVEFCKNHGILVEAY---GPLTPLRNPNPK---TDAL-----IEKLQNANHLTKSQALFRYLLDN 236
Cdd:cd19113 185 LQIEHhpYLQQPKL--IEYAQKAGITITAYssfGPQSFVELNQGRalnTPTLfehdtIKSIAAKHNKTPAQVLLRWATQR 262
|
250
....*....|....*....
gi 68482081 237 NILPITTSFKKERLKEALH 255
Cdd:cd19113 263 GIAVIPKSNLPERLLQNLS 281
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
38-200 |
7.64e-18 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 80.81 E-value: 7.64e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 38 VDILRYALSIGYNHIDTAEVY---TTQPEVGTAIAGF-QREKLWITTKYSV--TSSMIKKKSFTPTDF---VEQALDEMN 108
Cdd:cd19148 28 IETIHKALDLGINLIDTAPVYgfgLSEEIVGKALKEYgKRDRVVIATKVGLewDEGGEVVRNSSPARIrkeVEDSLRRLQ 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 109 TNYIDLLLIHFPpkpnDP--------YTIQSLWQEfvsikatGKVRYIGVSNFDIPQLNTLLEIGTPTINQIQYYLGSDN 180
Cdd:cd19148 108 TDYIDLYQVHWP----DPlvpieetaEALKELLDE-------GKIRAIGVSNFSPEQMETFRKVAPLHTVQPPYNLFERE 176
|
170 180
....*....|....*....|..
gi 68482081 181 LE--VVEFCKNHGILVEAYGPL 200
Cdd:cd19148 177 IEkdVLPYARKHNIVTLAYGAL 198
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
12-200 |
1.05e-17 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 80.33 E-value: 1.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 12 TIGIGTGTSIkdlkrGQPTAENKARivDILRYALSIGYNHIDTAEVYT-TQPE--VGTAIAGFQREKLWITTK--YSVTS 86
Cdd:cd19074 6 ELSLGTWLTF-----GGQVDDEDAK--ACVRKAYDLGINFFDTADVYAaGQAEevLGKALKGWPRESYVISTKvfWPTGP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 87 SmikkksftPTDF----------VEQALDEMNTNYIDLLLIHfPPKPNDPytIQSLWQEFVSIKATGKVRYIGVSNFDIP 156
Cdd:cd19074 79 G--------PNDRglsrkhifesIHASLKRLQLDYVDIYYCH-RYDPETP--LEETVRAMDDLIRQGKILYWGTSEWSAE 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 68482081 157 QLNTLLEIG------TPTINQIQYYLGSDN--LEVVEFCKNHGILVEAYGPL 200
Cdd:cd19074 148 QIAEAHDLArqfgliPPVVEQPQYNMLWREieEEVIPLCEKNGIGLVVWSPL 199
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
27-254 |
1.08e-17 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 79.95 E-value: 1.08e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 27 GQPTAENKAriVDILRYALSIGYNHIDTAEVYTtqPEV-----GTAIAGFqREKLWITTKYSVTSSmiKKKSFTP----- 96
Cdd:cd19088 18 GPPADREEA--IAVLRRALELGVNFIDTADSYG--PDVnerliAEALHPY-PDDVVIATKGGLVRT--GPGWWGPdgspe 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 97 --TDFVEQALDEMNTNYIDLLLIHfppKPNDPYTIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGTPTINQIQY 174
Cdd:cd19088 91 ylRQAVEASLRRLGLDRIDLYQLH---RIDPKVPFEEQLGALAELQDEGLIRHIGLSNVTVAQIEEARAIVRIVSVQNRY 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 175 YLGS-DNLEVVEFCKNHGILVEAYGPLT--PLRNPNPKTDALIEKLqnanHLTKSQALFRYLLD--NNILPITTSFKKER 249
Cdd:cd19088 168 NLANrDDEGVLDYCEAAGIAFIPWFPLGggDLAQPGGLLAEVAARL----GATPAQVALAWLLArsPVMLPIPGTSSVEH 243
|
....*
gi 68482081 250 LKEAL 254
Cdd:cd19088 244 LEENL 248
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
33-200 |
1.88e-17 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 78.67 E-value: 1.88e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 33 NKARIVDILRYALSIGYNHIDTAEVYTT-QPE--VGTAIAGfQREKLWITTK--YSVTSSMIKKKSFTP---TDFVEQAL 104
Cdd:cd19086 22 DDAEAIRALRAALDLGINFFDTADVYGDgHSErlLGKALKG-RRDKVVIATKfgNRFDGGPERPQDFSPeyiREAVEASL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 105 DEMNTNYIDLLLIHFPpkPNDPYTIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGTPTINQIQYylgsdNL--- 181
Cdd:cd19086 101 KRLGTDYIDLYQLHNP--PDEVLDNDELFEALEKLKQEGKIRAYGVSVGDPEEALAALRRGGIDVVQVIY-----NLldq 173
|
170 180
....*....|....*....|...
gi 68482081 182 ----EVVEFCKNHGILVEAYGPL 200
Cdd:cd19086 174 rpeeELFPLAEEHGVGVIARVPL 196
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
33-200 |
7.09e-17 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 78.76 E-value: 7.09e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 33 NKARIVDILRYALSIGYNHIDTAEVY--TTQPE--------VGTAIAGFQ-REKLWITTKYSVTSSMIKKKSFTPTDF-- 99
Cdd:cd19094 16 TEAEAHEQLDYAFDEGVNFIDTAEMYpvPPSPEtqgrteeiIGSWLKKKGnRDKVVLATKVAGPGEGITWPRGGGTRLdr 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 100 ------VEQALDEMNTNYIDLLLIHFPPKP-----NDPYTIQSLWQEFVSIKAT----------GKVRYIGVSN---FDI 155
Cdd:cd19094 96 enireaVEGSLKRLGTDYIDLYQLHWPDRYtplfgGGYYTEPSEEEDSVSFEEQlealgelvkaGKIRHIGLSNetpWGV 175
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 68482081 156 PQLNTLLEI-GTPTINQIQ--YYLGSDNLEV--VEFCKNHGILVEAYGPL 200
Cdd:cd19094 176 MKFLELAEQlGLPRIVSIQnpYSLLNRNFEEglAEACHRENVGLLAYSPL 225
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
25-174 |
8.62e-17 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 77.57 E-value: 8.62e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 25 KRGQPtaeNKARIVDILRYALSIGYNHIDTAEVYTTQPEV-GTAIAGFQREKlwITTKYSVTSSMIKKKSFTPTDFVEQA 103
Cdd:cd19097 19 KSGKP---SEKEAKKILEYALKAGINTLDTAPAYGDSEKVlGKFLKRLDKFK--IITKLPPLKEDKKEDEAAIEASVEAS 93
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 68482081 104 LDEMNTNYIDLLLIHfppKPND-PYTIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGTPTINQIQY 174
Cdd:cd19097 94 LKRLKVDSLDGLLLH---NPDDlLKHGGKLVEALLELKKEGLIRKIGVSVYSPEELEKALESFKIDIIQLPF 162
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
8-259 |
9.20e-16 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 75.29 E-value: 9.20e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 8 GDPITIgIGTGTSIKDLKRGQPTAENkarivdilryALSIGYNHIDTAEVYTTQPEVGTAIAG------FQREKLWITTK 81
Cdd:cd19114 1 GDKMPL-VGFGTAKIKANETEEVIYN----------AIKVGYRLIDGALLYGNEAEVGRGIRKaiqeglVKREDLFIVTK 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 82 YSvtssmikkKSFTPTDFVEQALD----EMNTNYIDLLLIHFP-------PKPNDPYT---------------IQSLWQE 135
Cdd:cd19114 70 LW--------NNFHGKDHVREAFDrqlkDYGLDYIDLYLIHFPipaayvdPAENYPFLwkdkelkkfpleqspMQECWRE 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 136 FVSIKATGKVRYIGVSNFDIPQLNTLLEIG--TPTINQIQY--YLGSDNLevVEFCKNHGILVEAY---GP--------- 199
Cdd:cd19114 142 MEKLVDAGLVRNIGIANFNVQLILDLLTYAkiKPAVLQIEHhpYLQQKRL--IDWAKKQGIQITAYssfGNavytkvtkh 219
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 68482081 200 ---LTPLRNpnpktDALIEKLQNANHLTKSQALFRYLLDNNILPITTSFKKERLKEALHSYTY 259
Cdd:cd19114 220 lkhFTNLLE-----HPVVKKLADKHKRDTGQVLLRWAVQRNITVIPKSVNVERMKTNLDITSY 277
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
40-254 |
1.78e-15 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 74.61 E-value: 1.78e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 40 ILRYALSIGYNHIDTAEVY-TTQPEV--GTAIAGfQREKLWITTKYSVtssmikkKSFTPTDF-------VEQALDEMNT 109
Cdd:cd19104 37 AVRRALDLGINFFDTAPSYgDGKSEEnlGRALKG-LPAGPYITTKVRL-------DPDDLGDIggqiersVEKSLKRLKR 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 110 NYIDLLLIH------------FPPKPNDPYTIQSLWQEFVSIKATGKVRYIGVSNFDIPQ-LNTLLEIGTPTINQIQYYL 176
Cdd:cd19104 109 DSVDLLQLHnrigderdkpvgGTLSTTDVLGLGGVADAFERLRSEGKIRFIGITGLGNPPaIRELLDSGKFDAVQVYYNL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 177 --------------GSDNLEVVEFCKNH-----GILVEAYGPLT------PLRNPNPKTDALIE--------KLQNANHL 223
Cdd:cd19104 189 lnpsaaearprgwsAQDYGGIIDAAAEHgvgvmGIRVLAAGALTtsldrgREAPPTSDSDVAIDfrraaafrALAREWGE 268
|
250 260 270
....*....|....*....|....*....|...
gi 68482081 224 TKSQALFRYLLDNNILP-ITTSFKK-ERLKEAL 254
Cdd:cd19104 269 TLAQLAHRFALSNPGVStVLVGVKNrEELEEAV 301
|
|
| AKR_AKR2D1 |
cd19115 |
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ... |
33-256 |
6.16e-15 |
|
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.
Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 72.84 E-value: 6.16e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 33 NKARIVDILRYALSIGYNHIDTAEVYTTQPEVGTAIA-----GF-QREKLWITTKYSvtssmikkKSFTPTDFVEQA--- 103
Cdd:cd19115 24 NNDTCADQVYNAIKAGYRLFDGACDYGNEVEAGQGVAraikeGIvKREDLFIVSKLW--------NTFHDGERVEPIcrk 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 104 -LDEMNTNYIDLLLIHFPP--KPNDP---Y----------------TIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTL 161
Cdd:cd19115 96 qLADWGIDYFDLFLIHFPIalKYVDPavrYppgwfydgkkvefsnaPIQETWTAMEKLVDKGLARSIGVSNFSAQLLMDL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 162 LEIGT--PTINQIQY--YLGSDNLevVEFCKNHGILVEAY---GPLT--PLRNPNPKTDAL------IEKLQNANHLTKS 226
Cdd:cd19115 176 LRYARirPATLQIEHhpYLTQPRL--VKYAQKEGIAVTAYssfGPQSflELDLPGAKDTPPlfehdvIKSIAEKHGKTPA 253
|
250 260 270
....*....|....*....|....*....|
gi 68482081 227 QALFRYLLDNNILPITTSFKKERLKEALHS 256
Cdd:cd19115 254 QVLLRWATQRGIAVIPKSNNPKRLAQNLDV 283
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
27-200 |
8.82e-15 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 72.61 E-value: 8.82e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 27 GQPTAENKARIVDilrYALSIGYNHIDTAEVYT---TQPEVGTAIAGfQREKLWITTKysVTSSMIKKksftPTD----- 98
Cdd:cd19087 25 GRTDEETSFAIMD---RALDAGINFFDTADVYGggrSEEIIGRWIAG-RRDDIVLATK--VFGPMGDD----PNDrglsr 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 99 -----FVEQALDEMNTNYIDLLLIHFPpkpnDPYT-IQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEI----GTPT 168
Cdd:cd19087 95 rhirrAVEASLRRLQTDYIDLYQMHHF----DRDTpLEETLRALDDLVRQGKIRYIGVSNFAAWQIAKAQGIaarrGLLR 170
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 68482081 169 INQIQ--YylgsdNL-------EVVEFCKNHGILVEAYGPL 200
Cdd:cd19087 171 FVSEQpmY-----NLlkrqaelEILPAARAYGLGVIPYSPL 206
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
27-200 |
4.89e-14 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 70.33 E-value: 4.89e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 27 GQPTAENKARIVDIlryALSIGYNHIDTAEVYTT-QPEV--GTAIAGfQREKLWITTKysVTSSMikkkSFTPTDF---- 99
Cdd:cd19091 34 GGVDQEEADRLVDI---ALDAGINFFDTADVYSEgESEEilGKALKG-RRDDVLIATK--VRGRM----GEGPNDVglsr 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 100 ------VEQALDEMNTNYIDLLLIHFPpkpnDPYT-----IQSLwQEFVsikATGKVRYIGVSNFDIPQLNTLLEI---- 164
Cdd:cd19091 104 hhiiraVEASLKRLGTDYIDLYQLHGF----DALTpleetLRAL-DDLV---RQGKVRYIGVSNFSAWQIMKALGIserr 175
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 68482081 165 --GTPTINQIQYYLGSDNL--EVVEFCKNHGILVEAYGPL 200
Cdd:cd19091 176 glARFVALQAYYSLLGRDLehELMPLALDQGVGLLVWSPL 215
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
16-200 |
1.07e-13 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 69.17 E-value: 1.07e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 16 GTGTSIKDLKRGQPTAENKArivdILRYALSIGYNHIDTAEVYTT-QPE--VGTAIAGfQREKLWITTKYSVTSSMIK-- 90
Cdd:cd19080 16 GTMTFGTEWGWGADREEARA----MFDAYVEAGGNFIDTANNYTNgTSErlLGEFIAG-NRDRIVLATKYTMNRRPGDpn 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 91 -----KKSFTPTdfVEQALDEMNTNYIDLLLIHFPpkpnDPYT-IQSLWQEFVSIKATGKVRYIGVSNFD---IPQLNTL 161
Cdd:cd19080 91 aggnhRKNLRRS--VEASLRRLQTDYIDLLYVHAW----DFTTpVEEVMRALDDLVRAGKVLYVGISDTPawvVARANTL 164
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 68482081 162 LEI-G-TPTIN-QIQYYLGSDNLE--VVEFCKNHGILVEAYGPL 200
Cdd:cd19080 165 AELrGwSPFVAlQIEYSLLERTPEreLLPMARALGLGVTPWSPL 208
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
29-200 |
2.22e-13 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 68.35 E-value: 2.22e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 29 PTAENKAriVDILRYALSIGYNHIDTAEVY--TTQPEV-GTAIAGFQREKLWITTK---YSVTSsmikKKSFtptDF--- 99
Cdd:cd19163 29 PVDEEEA--IRTVHEALDSGINYIDTAPWYgqGRSETVlGKALKGIPRDSYYLATKvgrYGLDP----DKMF---DFsae 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 100 -----VEQALDEMNTNYIDLLLIH---FPPKP----NDpyTIQSLwqefVSIKATGKVRYIGVSNFDIPQLNTLLEIGTP 167
Cdd:cd19163 100 ritksVEESLKRLGLDYIDIIQVHdieFAPSLdqilNE--TLPAL----QKLKEEGKVRFIGITGYPLDVLKEVLERSPV 173
|
170 180 190
....*....|....*....|....*....|....*...
gi 68482081 168 TINQIQYY-----LGSDNLEVVEFCKNHGILVEAYGPL 200
Cdd:cd19163 174 KIDTVLSYchytlNDTSLLELLPFFKEKGVGVINASPL 211
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
44-197 |
3.25e-13 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 67.74 E-value: 3.25e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 44 ALSIGYNHIDTAEVY---TTQPEVGTAIAGFQREKLWITTKYsvTSSMIKKKSFTPTDFVEQALDEMNTNYIDLLLIHFP 120
Cdd:cd19103 41 AMAAGLNLWDTAAVYgmgASEKILGEFLKRYPREDYIISTKF--TPQIAGQSADPVADMLEGSLARLGTDYIDIYWIHNP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 121 P--KPNDPYTIqSLWQEfvsikatGKVRYIGVSNF---DIPQLNTLLEIGTPTINQIQ-----YYLGSDNLEVVEFCKNH 190
Cdd:cd19103 119 AdvERWTPELI-PLLKS-------GKVKHVGVSNHnlaEIKRANEILAKAGVSLSAVQnhyslLYRSSEEAGILDYCKEN 190
|
....*..
gi 68482081 191 GILVEAY 197
Cdd:cd19103 191 GITFFAY 197
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
40-200 |
6.42e-13 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 67.22 E-value: 6.42e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 40 ILRYALSIGYNHIDTAEVY---TTQPEVGTAIAGF-QREKLWITTK-YSVTSSMIKKKSFTPT---DFVEQALDEMNTNY 111
Cdd:cd19079 40 IIKRALDLGINFFDTANVYsggASEEILGRALKEFaPRDEVVIATKvYFPMGDGPNGRGLSRKhimAEVDASLKRLGTDY 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 112 IDLLLIHFPpKPNDPY--TIQSLwQEFVSikaTGKVRYIGVSNFDIPQLNTLLEIG-----TPTIN-QIQYylgsdNL-- 181
Cdd:cd19079 120 IDLYQIHRW-DYETPIeeTLEAL-HDVVK---SGKVRYIGASSMYAWQFAKALHLAekngwTKFVSmQNHY-----NLly 189
|
170 180
....*....|....*....|....
gi 68482081 182 -----EVVEFCKNHGILVEAYGPL 200
Cdd:cd19079 190 reeerEMIPLCEEEGIGVIPWSPL 213
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
26-256 |
6.63e-13 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 66.87 E-value: 6.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 26 RGQPTAENKAriVDILRYALSIGYNHIDTAEVY---TTQPEVGTAIAGFqREKLWITTKYSVTSSMIKKKSFTP------ 96
Cdd:cd19078 18 YGPPPDKEEM--IELIRKAVELGITFFDTAEVYgpyTNEELVGEALKPF-RDQVVIATKFGFKIDGGKPGPLGLdsrpeh 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 97 -TDFVEQALDEMNTNYIDLLLIHFPPkPNDPY-----TIQSLWQEfvsikatGKVRYIGVSnfdipqlntllEIGTPTIN 170
Cdd:cd19078 95 iRKAVEGSLKRLQTDYIDLYYQHRVD-PNVPIeevagTMKELIKE-------GKIRHWGLS-----------EAGVETIR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 171 -----------QIQYYLGSDNLE--VVEFCKNHGILVEAYGP-----LTPLRNPNPKTDA-------------------- 212
Cdd:cd19078 156 rahavcpvtavQSEYSMMWREPEkeVLPTLEELGIGFVPFSPlgkgfLTGKIDENTKFDEgddraslprftpealeanqa 235
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 68482081 213 ---LIEKLQNANHLTKSQALFRYLLDN--NILPITTSFKKERLKEALHS 256
Cdd:cd19078 236 lvdLLKEFAEEKGATPAQIALAWLLAKkpWIVPIPGTTKLSRLEENIGA 284
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
35-151 |
7.00e-13 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 66.81 E-value: 7.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 35 ARIVDILRYALSIGYNHIDTAEVYTTQPE-VGTAIAGFQREKLWITTKysvtssmIKKKSFTPTDF--------VEQALD 105
Cdd:cd19090 20 DEAVATIRAALDLGINYIDTAPAYGDSEErLGLALAELPREPLVLSTK-------VGRLPEDTADYsadrvrrsVEESLE 92
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 68482081 106 EMNTNYIDLLLIHfppkpnDPYTIQsLWQEF---------VSIKATGKVRYIGVS 151
Cdd:cd19090 93 RLGRDRIDLLMIH------DPERVP-WVDILapggalealLELKEEGLIKHIGLG 140
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
27-200 |
1.50e-12 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 66.09 E-value: 1.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 27 GQPTAENKArivdILRYALSIGYNHIDTAEVY---TTQPEVGTAIAGFqREKLWITTKYSVTssMIKKKSFTPTD----F 99
Cdd:cd19076 28 PADEEESIA----TLHRALELGVTFLDTADMYgpgTNEELLGKALKDR-RDEVVIATKFGIV--RDPGSGFRGVDgrpeY 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 100 VEQALDE----MNTNYIDLLLIHFPPkPNDPytIQSLWQEFVSIKATGKVRYIGVSnfdipqlntllEIGTPTIN----- 170
Cdd:cd19076 101 VRAACEAslkrLGTDVIDLYYQHRVD-PNVP--IEETVGAMAELVEEGKVRYIGLS-----------EASADTIRrahav 166
|
170 180 190
....*....|....*....|....*....|....*...
gi 68482081 171 ------QIQYYLGSDNLE--VVEFCKNHGILVEAYGPL 200
Cdd:cd19076 167 hpitavQSEYSLWTRDIEdeVLPTCRELGIGFVAYSPL 204
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
48-200 |
1.54e-12 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 66.08 E-value: 1.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 48 GYNHIDTAEVYTTQPE----------VGTAIAG-FQREKLWITTKysVTSSM-IKKKSFTP---TDFVEQALDEMNTNYI 112
Cdd:cd19081 39 GGNFIDTADVYSAWVPgnaggesetiIGRWLKSrGKRDRVVIATK--VGFPMgPNGPGLSRkhiRRAVEASLRRLQTDYI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 113 DLLLIHFPpkpnDPYTIQSlwqEFVS-----IKAtGKVRYIGVSNFDIPQLNTLLEI----GTPTIN--QIQYYL---GS 178
Cdd:cd19081 117 DLYQAHWD----DPATPLE---ETLGalndlIRQ-GKVRYIGASNYSAWRLQEALELsrqhGLPRYVslQPEYNLvdrES 188
|
170 180
....*....|....*....|..
gi 68482081 179 DNLEVVEFCKNHGILVEAYGPL 200
Cdd:cd19081 189 FEGELLPLCREEGIGVIPYSPL 210
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
5-235 |
8.02e-12 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 63.88 E-value: 8.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 5 TVSgdpiTIGIGTgtsikdlKRGQPTAENKARIVDILRYALSIGYNHIDTAEVYTTQ---PEVGTAIA------GFQREK 75
Cdd:cd19099 2 TLS----SLGLGT-------YRGDSDDETDEEYREALKAALDSGINVIDTAINYRGGrseRLIGKALReliekgGIKRDE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 76 LWITTK--------------------YSVTSSMIKK------KSFTPtDFVEQALD----EMNTNYIDLLLIHFPPKPND 125
Cdd:cd19099 71 VVIVTKagyipgdgdeplrplkyleeKLGRGLIDVAdsaglrHCISP-AYLEDQIErslkRLGLDTIDLYLLHNPEEQLL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 126 PYTIQSLWQEFV-------SIKATGKVRYIGVSNFDIPQ------------------------------LNTLLEIGTPT 168
Cdd:cd19099 150 ELGEEEFYDRLEeafealeEAVAEGKIRYYGISTWDGFRappalpghlsleklvaaaeevggdnhhfkvIQLPLNLLEPE 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 68482081 169 INQIQYYLGSDNLEVVEFCKNHGILVEAYGPLTPLRNPNPKTDALIEKLQNANHLtkSQALFRYLLD 235
Cdd:cd19099 230 ALTEKNTVKGEALSLLEAAKELGLGVIASRPLNQGQLLGELRLADLLALPGGATL--AQRALQFARS 294
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
25-200 |
2.97e-11 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 62.23 E-value: 2.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 25 KRGQPTAENKArIVDILRYALSiGYNHIDTAEVYTTQPE-VGTAIAGFQRE-----KLWITTKYSVTSSMIK-KKSFTpT 97
Cdd:cd19101 15 GHGGIRDEDAA-VRAMAAYVDA-GLTTFDCADIYGPAEElIGEFRKRLRRErdaadDVQIHTKWVPDPGELTmTRAYV-E 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 98 DFVEQALDEMNTNYIDLLLIHFPpKPNDPYTIQSLwQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGTPTI-NQIQYYL 176
Cdd:cd19101 92 AAIDRSLKRLGVDRLDLVQFHWW-DYSDPGYLDAA-KHLAELQEEGKIRHLGLTNFDTERLREILDAGVPIVsNQVQYSL 169
|
170 180
....*....|....*....|....*..
gi 68482081 177 gSD---NLEVVEFCKNHGILVEAYGPL 200
Cdd:cd19101 170 -LDrrpENGMAALCEDHGIKLLAYGTL 195
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
10-164 |
5.47e-11 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 61.52 E-value: 5.47e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 10 PITIGIGTgtsikdLKRGQPTAENKARIVDILRYALSIGYNHIDTAEVYTTQPEV-GTAIA----GFQREKLWITTK--- 81
Cdd:cd19164 15 PLIFGAAT------FSYQYTTDPESIPPVDIVRRALELGIRAFDTSPYYGPSEIIlGRALKalrdEFPRDTYFIITKvgr 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 82 -------YSvtSSMIKKKsftptdfVEQALDEMNTNYIDLLLIH---FPPkpnDPYTIQSLwQEFVSIKATGKVRYIGVS 151
Cdd:cd19164 89 ygpddfdYS--PEWIRAS-------VERSLRRLHTDYLDLVYLHdveFVA---DEEVLEAL-KELFKLKDEGKIRNVGIS 155
|
170
....*....|...
gi 68482081 152 NFDIPqlnTLLEI 164
Cdd:cd19164 156 GYPLP---VLLRL 165
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
10-200 |
6.16e-11 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 61.42 E-value: 6.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 10 PITIgIGTGTSIKDlkRGQPTAENKARIVDILRyalSIGYNHIDTAEVY---TTQPEVGTAIAGFQREKlwITTKYSVTS 86
Cdd:cd19075 1 PKII-LGTMTFGSQ--GRFTTAEAAAELLDAFL---ERGHTEIDTARVYpdgTSEELLGELGLGERGFK--IDTKANPGV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 87 smikKKSFTPTDFVEQA---LDEMNTNYIDLLLIHFPpkpnDPYT--------IQSLWQEfvsikatGKVRYIGVSNFDI 155
Cdd:cd19075 73 ----GGGLSPENVRKQLetsLKRLKVDKVDVFYLHAP----DRSTpleetlaaIDELYKE-------GKFKEFGLSNYSA 137
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 68482081 156 PQLNTLLEI----G--TPTINQIQYylgsdNL-------EVVEFCKNHGILVEAYGPL 200
Cdd:cd19075 138 WEVAEIVEIckenGwvLPTVYQGMY-----NAitrqvetELFPCLRKLGIRFYAYSPL 190
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
12-200 |
9.11e-11 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 61.02 E-value: 9.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 12 TIGIGTGTSikdlkrGQPTAENKARIVdiLRYALSIGYNHIDTAEVYTTQPE----------VGTAIAGF-QREKLWITT 80
Cdd:PRK10625 15 TLGLGTMTF------GEQNSEADAHAQ--LDYAVAQGINLIDVAEMYPVPPRpetqgltetyIGNWLAKRgSREKLIIAS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 81 KYSVTS----SMIKKKSFTPTDFVEQALDE----MNTNYIDLLLIHFPPKPNDPY------------------TIQSLwQ 134
Cdd:PRK10625 87 KVSGPSrnndKGIRPNQALDRKNIREALHDslkrLQTDYLDLYQVHWPQRPTNCFgklgyswtdsapavslleTLDAL-A 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68482081 135 EFVSikaTGKVRYIGVSN---FDIPQLNTLLEI-GTPTINQIQ--YYLGSDNLEV--VEFCKNHGILVEAYGPL 200
Cdd:PRK10625 166 EQQR---AGKIRYIGVSNetaFGVMRYLHLAEKhDLPRIVTIQnpYSLLNRSFEVglAEVSQYEGVELLAYSCL 236
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
40-256 |
2.54e-10 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 59.76 E-value: 2.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 40 ILRYALSIGYNHIDTAEVYTTQPE---VGTAIAGFQREKLWITTKYSVTssMIKKKSFTPTD--------FVEQALDEMN 108
Cdd:cd19144 39 VLDAAFELGCTFWDTADIYGDSEEligRWFKQNPGKREKIFLATKFGIE--KNVETGEYSVDgspeyvkkACETSLKRLG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 109 TNYIDLLLIHfppkPNDPYT-IQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGTPTINQIQYY-----LGSDNLE 182
Cdd:cd19144 117 VDYIDLYYQH----RVDGKTpIEKTVAAMAELVQEGKIKHIGLSECSAETLRRAHAVHPIAAVQIEYSpfsldIERPEIG 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 183 VVEFCKNHGILVEAYGPL-----------------TPLRNPNPKTDA-----------LIEKLQNANHLTKSQALFRYLL 234
Cdd:cd19144 193 VLDTCRELGVAIVAYSPLgrgfltgairspddfeeGDFRRMAPRFQAenfpknlelvdKIKAIAKKKNVTAGQLTLAWLL 272
|
250 260
....*....|....*....|....
gi 68482081 235 --DNNILPITTSFKKERLKEALHS 256
Cdd:cd19144 273 aqGDDIIPIPGTTKLKRLEENLGA 296
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
27-200 |
1.02e-09 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 57.83 E-value: 1.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 27 GQPTAENKAriVDILRYALSIGYNHIDTAEVY---TTQPEVGTAIAGFQREKLWITTKYSVTSSMIKKKSFTPT-DFV-- 100
Cdd:cd19145 27 GAPKPEEEG--IALIHHAFNSGVTFLDTSDIYgpnTNEVLLGKALKDGPREKVQLATKFGIHEIGGSGVEVRGDpAYVra 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 101 --EQALDEMNTNYIDLLLIHfppKPNDPYTIQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGTPTINQIQYYLGS 178
Cdd:cd19145 105 acEASLKRLDVDYIDLYYQH---RIDTTVPIEITMGELKKLVEEGKIKYIGLSEASADTIRRAHAVHPITAVQLEWSLWT 181
|
170 180
....*....|....*....|....
gi 68482081 179 DNLE--VVEFCKNHGILVEAYGPL 200
Cdd:cd19145 182 RDIEeeIIPTCRELGIGIVPYSPL 205
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
40-200 |
3.43e-09 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 56.11 E-value: 3.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 40 ILRYALSIGYNHIDTAEVYTtqPEVGTAIAGF----------QREKLWITTK---------YSVTSSmikKKSFTPTdfV 100
Cdd:cd19089 34 LLRTAFDLGITHFDLANNYG--PPPGSAEENFgrilkrdlrpYRDELVISTKagygmwpgpYGDGGS---RKYLLAS--L 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 101 EQALDEMNTNYIDLLLIHfPPKPNDPY--TIQSLWQEFVSikatGKVRYIGVSNFDIPQLNTLLEI----GTP-TINQIQ 173
Cdd:cd19089 107 DQSLKRMGLDYVDIFYHH-RYDPDTPLeeTMTALADAVRS----GKALYVGISNYPGAKARRAIALlrelGVPlIIHQPR 181
|
170 180
....*....|....*....|....*....
gi 68482081 174 YYLGSDNLE--VVEFCKNHGILVEAYGPL 200
Cdd:cd19089 182 YSLLDRWAEdgLLEVLEEAGIGFIAFSPL 210
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
14-175 |
7.16e-09 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 55.23 E-value: 7.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 14 GIGTGTSIKDLKRGQPTAENKAriVDILRYALSIGYNHIDTAEVY---TTQPEVGTAIA--GFQREKLWITTKysvtSSM 88
Cdd:cd19153 14 PVGLGTAALGGVYGDGLEQDEA--VAIVAEAFAAGINHFDTSPYYgaeSSEAVLGKALAalQVPRSSYTVATK----VGR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 89 IKKKSF-TPTDFVEQALDE----MNTNYIDLLLIH---FPPKpnDPYTIQSLwQEFVSIKATGKVRYIGVSNFDIPQLNT 160
Cdd:cd19153 88 YRDSEFdYSAERVRASVATslerLHTTYLDVVYLHdieFVDY--DTLVDEAL-PALRTLKDEGVIKRIGIAGYPLDTLTR 164
|
170
....*....|....*.
gi 68482081 161 LLEIGTP-TINQIQYY 175
Cdd:cd19153 165 ATRRCSPgSLDAVLSY 180
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
33-156 |
1.42e-08 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 54.35 E-value: 1.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 33 NKARIVDILRYALSIGYNHIDTAEVY---TTQPEVGTAIAGFQ-REKLWITTKYSVTSSM---IKKKSFTPTDF------ 99
Cdd:cd19146 33 DKETAFKLLDAFYEQGGNFIDTANNYqgeESERWVGEWMASRGnRDEMVLATKYTTGYRRggpIKIKSNYQGNHakslrl 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 100 -VEQALDEMNTNYIDLLLIHFPpkpndPYT--IQSLWQEFVSIKATGKVRYIGVSnfDIP 156
Cdd:cd19146 113 sVEASLKKLQTSYIDILYVHWW-----DYTtsIPELMQSLNHLVAAGKVLYLGVS--DTP 165
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
30-254 |
9.59e-07 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 48.70 E-value: 9.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 30 TAENKARIVDILRYALSIGYNHIDTAEVYTTQPEVGTA-------IAGFQ-REKLWITTK---YSVTSSMIKKksFTPTD 98
Cdd:cd19082 12 TRIDEEEAFALLDAFVELGGNFIDTARVYGDWVERGAServigewLKSRGnRDKVVIATKgghPDLEDMSRSR--LSPED 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 99 F---VEQALDEMNTNYIDLLLIHF--PPKPNDPytIQSLWQEFVsikATGKVRYIGVSNFDIPQL----NTLLEIG--TP 167
Cdd:cd19082 90 IradLEESLERLGTDYIDLYFLHRddPSVPVGE--IVDTLNELV---RAGKIRAFGASNWSTERIaeanAYAKAHGlpGF 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 168 TINQIQYYL-------------GSDNLEVVEFCKNHGILVEAYGPL----------TPLRNPNPK-----TDALIEKLQN 219
Cdd:cd19082 165 AASSPQWSLarpneppwpgptlVAMDEEMRAWHEENQLPVFAYSSQargffskraaGGAEDDSELrrvyySEENFERLER 244
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 68482081 220 ANHLTK------SQALFRYLLDN--NILPITTSFKKERLKEAL 254
Cdd:cd19082 245 AKELAEekgvspTQIALAYVLNQpfPTVPIIGPRTPEQLRDSL 287
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
32-256 |
1.48e-06 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 48.10 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 32 ENKARIVDilRYaLSIGYNHIDTAEVYTTQPEVGTA-----IAG------FQREKLWITTKY-----SVTSSMIKKKSFT 95
Cdd:cd19752 17 ETSFAILD--RY-VAAGGNFLDTANNYAFWTEGGVGgeserLIGrwlkdrGNRDDVVIATKVgagprDPDGGPESPEGLS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 96 PtDFVEQALDE----MNTNYIDLLLIHFppkpNDPYT-IQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGT---- 166
Cdd:cd19752 94 A-ETIEQEIDKslrrLGTDYIDLYYAHV----DDRDTpLEETLEAFNELVKAGKVRAIGASNFAAWRLERARQIARqqgw 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 167 --PTINQIQY-YL----GSD-------NLEVVEFCKNHGIL-VEAYGPL---------TPLRNP--NPKTDALIEKLQN- 219
Cdd:cd19752 169 aeFSAIQQRHsYLrprpGADfgvqrivTDELLDYASSRPDLtLLAYSPLlsgaytrpdRPLPEQydGPDSDARLAVLEEv 248
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 68482081 220 ANHL--TKSQALFRYLLDN--NILPITTSFKKERLKEALHS 256
Cdd:cd19752 249 AGELgaTPNQVVLAWLLHRtpAIIPLLGASTVEQLEENLAA 289
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
40-200 |
1.23e-05 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 45.69 E-value: 1.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 40 ILRYALSIGYNHIDTAEVYTTQPEVGTA--IAGF------QREKLWIttkySVTSSMIKKkSFTPT---DFVEQALDEMN 108
Cdd:cd19077 30 TMKAALDAGSNLWNGGEFYGPPDPHANLklLARFfrkypeYADKVVL----SVKGGLDPD-TLRPDgspEAVRKSIENIL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 109 -----TNYIDLL-LIHFPPKPNDPYTIQSLwQEFVsikATGKVRYIGVSNFDIPQLNTLLEIGTPTINQIQYYLGS---- 178
Cdd:cd19077 105 ralggTKKIDIFePARVDPNVPIEETIKAL-KELV---KEGKIRGIGLSEVSAETIRRAHAVHPIAAVEVEYSLFSreie 180
|
170 180
....*....|....*....|..
gi 68482081 179 DNlEVVEFCKNHGILVEAYGPL 200
Cdd:cd19077 181 EN-GVLETCAELGIPIIAYSPL 201
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
40-174 |
1.15e-04 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 42.78 E-value: 1.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 40 ILRYALSIGYNHIDTAEVYTtqPEVGTAIAGF----------QREKLWITTK---------YSVTSSmikKKSFTPTdfV 100
Cdd:cd19151 35 MLRRAFDLGITHFDLANNYG--PPPGSAEENFgrilkedlkpYRDELIISTKagytmwpgpYGDWGS---KKYLIAS--L 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 101 EQALDEMNTNYIDLLLiHFPPKPNDPY--TIQSLWQefvsIKATGKVRYIGVSNFDIPQ----LNTLLEIGTPT-INQIQ 173
Cdd:cd19151 108 DQSLKRMGLDYVDIFY-HHRPDPETPLeeTMGALDQ----IVRQGKALYVGISNYPPEEareaAAILKDLGTPClIHQPK 182
|
.
gi 68482081 174 Y 174
Cdd:cd19151 183 Y 183
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
13-202 |
6.88e-04 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 40.03 E-value: 6.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 13 IGIGTGTsikdlkRGQPTAENKARIVDILRYALSIGYNHIDTAEVY---TTQPEVGTAIAGFQREKLWITTKYSVTSSMI 89
Cdd:cd19162 3 LGLGAAS------LGNLARAGEDEAAATLDAAWDAGIRYFDTAPLYglgLSERRLGAALARHPRAEYVVSTKVGRLLEPG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 90 KKKSFTPTDF------------VEQALDEMNTNYIDLLLIHFPPkPNDPYTIQSLWQEFVSIKATGKVRYIGVSNFDIPQ 157
Cdd:cd19162 77 AAGRPAGADRrfdfsadgirrsIEASLERLGLDRLDLVFLHDPD-RHLLQALTDAFPALEELRAEGVVGAIGVGVTDWAA 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 68482081 158 LNTLLEIGTPTINQI--QYYLGSDN--LEVVEFCKNHGILVEAYGPLTP 202
Cdd:cd19162 156 LLRAARRADVDVVMVagRYTLLDRRaaTELLPLCAAKGVAVVAAGVFNS 204
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
10-152 |
6.89e-04 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 40.19 E-value: 6.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 10 PITIGigtGTSIKDLKRGQPTAENKARIVDILRYALSIGYNHIDTAEVYTT-QPE--VGTAIAGFQ-REKLWITTKYSVT 85
Cdd:cd19147 12 PLILG---AMSIGDAWSGFMGSMDKEQAFELLDAFYEAGGNFIDTANNYQDeQSEtwIGEWMKSRKnRDQIVIATKFTTD 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 86 SSMIKKKSFTPTDF-----------VEQALDEMNTNYIDLLLIHFppkpndpytiqslWQEFVSIKAT----------GK 144
Cdd:cd19147 89 YKAYEVGKGKAVNYcgnhkrslhvsVRDSLRKLQTDWIDILYVHW-------------WDYTTSIEEVmdslhilvqqGK 155
|
....*...
gi 68482081 145 VRYIGVSN 152
Cdd:cd19147 156 VLYLGVSD 163
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
12-118 |
2.63e-03 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 38.60 E-value: 2.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 12 TIGIGTGTSIkdlkrGQPTAENKARivDILRYALSIGYNHIDTAEVYTtQPEVGTAIAGFQREKLWITTKYSVTSSMIKK 91
Cdd:cd19142 15 NVGLGTWSTF-----STAISEEQAE--EIVTLAYENGINYFDTSDAFT-SGQAETELGRILKKKGWKRSSYIVSTKIYWS 86
|
90 100 110
....*....|....*....|....*....|....*..
gi 68482081 92 KsfTPTD----------FVEQALDEMNTNYIDLLLIH 118
Cdd:cd19142 87 Y--GSEErglsrkhiieSVRASLRRLQLDYIDIVIIH 121
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
39-200 |
8.29e-03 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 36.81 E-value: 8.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 39 DILRYALSIGYNHIDTAEVYTT-QPEV--GTAI--AGFQREKLWITTKY-------SVTSSMIKKKSFtpTDFVEQALDE 106
Cdd:cd19143 35 ECMKAAYDAGVNFFDNAEVYANgQSEEimGQAIkeLGWPRSDYVVSTKIfwggggpPPNDRGLSRKHI--VEGTKASLKR 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68482081 107 MNTNYIDLLLIHFPpkpnDPYT-IQSLWQEFVSIKATGKVRYIGVSNFDIPQLNTLLEIGT------PTINQIQY-YLGS 178
Cdd:cd19143 113 LQLDYVDLVFCHRP----DPATpIEETVRAMNDLIDQGKAFYWGTSEWSAQQIEEAHEIADrlglipPVMEQPQYnLFHR 188
|
170 180
....*....|....*....|....
gi 68482081 179 DNLEV--VEFCKNHGILVEAYGPL 200
Cdd:cd19143 189 ERVEVeyAPLYEKYGLGTTTWSPL 212
|
|
| |
