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Conserved domains on  [gi|2795024587|ref|XP_067797952|]
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histone H2A.Z [Phytophthora cinnamomi]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00154 super family cl30550
histone H2A; Provisional
 21-132 9.08e-63

histone H2A; Provisional


The actual alignment was detected with superfamily member PLN00154:

Pssm-ID: 177756  Cd Length: 136  Bit Score: 188.23  E-value: 9.08e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2795024587  21 KRAPQSRSQRAGLQFPVGRIHRFLKKRVANNQRVGATAAVYAAAIMEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRG 100
Cdd:PLN00154   25 KKKPTSRSSRAGLQFPVGRIHRQLKQRVSAHGRVGATAAVYTAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRG 104

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2795024587 101 DEELDTLIKATIAGGGVIPHIHKNLITKQNKK 132
Cdd:PLN00154  105 DEELDTLIKGTIAGGGVIPHIHKSLINKSTKK 136
 
Name Accession Description Interval E-value
PLN00154 PLN00154
histone H2A; Provisional
 21-132 9.08e-63

histone H2A; Provisional


Pssm-ID: 177756  Cd Length: 136  Bit Score: 188.23  E-value: 9.08e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2795024587  21 KRAPQSRSQRAGLQFPVGRIHRFLKKRVANNQRVGATAAVYAAAIMEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRG 100
Cdd:PLN00154   25 KKKPTSRSSRAGLQFPVGRIHRQLKQRVSAHGRVGATAAVYTAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRG 104

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2795024587 101 DEELDTLIKATIAGGGVIPHIHKNLITKQNKK 132
Cdd:PLN00154  105 DEELDTLIKGTIAGGGVIPHIHKSLINKSTKK 136
H2A smart00414
Histone 2A;
26-131 4.67e-48

Histone 2A;


Pssm-ID: 197711  Cd Length: 106  Bit Score: 149.79  E-value: 4.67e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2795024587   26 SRSQRAGLQFPVGRIHRFLKKRvANNQRVGATAAVYAAAIMEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELD 105
Cdd:smart00414   1 SRSARAGLQFPVGRIHRLLRKG-TYAKRVGAGAPVYLAAVLEYLTAEVLELAGNAARDNKKRRITPRHLQLAIRNDEELN 79

                           90       100
                   ....*....|....*....|....*..
gi 2795024587  106 TLIKA-TIAGGGVIPHIHKNLITKQNK 131
Cdd:smart00414  80 KLLKGvTIAQGGVLPNIHKVLLPKKTG 106
HTA1 COG5262
Histone H2A [Chromatin structure and dynamics];
22-132 9.64e-44

Histone H2A [Chromatin structure and dynamics];


Pssm-ID: 227587 [Multi-domain]  Cd Length: 132  Bit Score: 140.00  E-value: 9.64e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2795024587  22 RAPQSRSQRAGLQFPVGRIHRFLKKRvANNQRVGATAAVYAAAIMEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGD 101
Cdd:COG5262    14 RVSQSRSAKAGLIFPVGRVKRLLKKG-NYRMRIGAGAPVYLAAVLEYLAAEILELAGNAARDNKKKRIIPRHLQLAIRND 92

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2795024587 102 EELDTLIK-ATIAGGGVIPHIHKNLITKQNKK 132
Cdd:COG5262    93 EELNKLLGdVTIAQGGVLPNINPGLLPKSSKK 124
HFD_H2A cd00074
histone-fold domain found in histone H2A and similar proteins; Histone H2A is the core ...
 25-112 1.65e-36

histone-fold domain found in histone H2A and similar proteins; Histone H2A is the core component of the nucleosome, which wraps and compacts DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.


Pssm-ID: 467020  Cd Length: 89  Bit Score: 119.95  E-value: 1.65e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2795024587  25 QSRSQRAGLQFPVGRIHRFLKKRVANnQRVGATAAVYAAAIMEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEEL 104
Cdd:cd00074     1 QSRSKRAGLQFPVGRIHRLLKKGTYA-KRVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKKRITPRHIQLAIRNDEEL 79


                  ....*...
gi 2795024587 105 DTLIKATI 112
Cdd:cd00074    80 NKLFKGVT 87
Histone pfam00125
Core histone H2A/H2B/H3/H4;
21-101 1.12e-14

Core histone H2A/H2B/H3/H4;


Pssm-ID: 459682 [Multi-domain]  Cd Length: 126  Bit Score: 65.53  E-value: 1.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2795024587  21 KRAPQSRSQRAGLQFPVGRIHRFLKKRVANNQRVGATAAVYAAAIMEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRG 100
Cdd:pfam00125  46 IRKYQSSTDLLIYKLPFARVVREVVQSTKTDLRISADAVVALQEAVEDFLVELFEEANLLAIHAKRVTLTPKDIQLARRL 125


                  .
gi 2795024587 101 D 101
Cdd:pfam00125 126 R 126
 
Name Accession Description Interval E-value
PLN00154 PLN00154
histone H2A; Provisional
 21-132 9.08e-63

histone H2A; Provisional


Pssm-ID: 177756  Cd Length: 136  Bit Score: 188.23  E-value: 9.08e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2795024587  21 KRAPQSRSQRAGLQFPVGRIHRFLKKRVANNQRVGATAAVYAAAIMEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRG 100
Cdd:PLN00154   25 KKKPTSRSSRAGLQFPVGRIHRQLKQRVSAHGRVGATAAVYTAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRG 104

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2795024587 101 DEELDTLIKATIAGGGVIPHIHKNLITKQNKK 132
Cdd:PLN00154  105 DEELDTLIKGTIAGGGVIPHIHKSLINKSTKK 136
PTZ00017 PTZ00017
histone H2A; Provisional
 19-132 7.75e-56

histone H2A; Provisional


Pssm-ID: 185399  Cd Length: 134  Bit Score: 170.70  E-value: 7.75e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2795024587  19 TSKRAPQSRSQRAGLQFPVGRIHRFLKKRVANnQRVGATAAVYAAAIMEYLTAEVLELAGNASKDLKVKRITPRHLQLAI 98
Cdd:PTZ00017   12 AGKKKPVSRSAKAGLQFPVGRVHRYLKKGRYA-KRVGAGAPVYLAAVLEYLTAEVLELAGNAAKDNKKKRITPRHIQLAI 90

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2795024587  99 RGDEELDTLI-KATIAGGGVIPHIHKNLITKQNKK 132
Cdd:PTZ00017   91 RNDEELNKLLaGVTIASGGVLPNIHKVLLPKKSKP 125
H2A smart00414
Histone 2A;
26-131 4.67e-48

Histone 2A;


Pssm-ID: 197711  Cd Length: 106  Bit Score: 149.79  E-value: 4.67e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2795024587   26 SRSQRAGLQFPVGRIHRFLKKRvANNQRVGATAAVYAAAIMEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELD 105
Cdd:smart00414   1 SRSARAGLQFPVGRIHRLLRKG-TYAKRVGAGAPVYLAAVLEYLTAEVLELAGNAARDNKKRRITPRHLQLAIRNDEELN 79

                           90       100
                   ....*....|....*....|....*..
gi 2795024587  106 TLIKA-TIAGGGVIPHIHKNLITKQNK 131
Cdd:smart00414  80 KLLKGvTIAQGGVLPNIHKVLLPKKTG 106
HTA1 COG5262
Histone H2A [Chromatin structure and dynamics];
22-132 9.64e-44

Histone H2A [Chromatin structure and dynamics];


Pssm-ID: 227587 [Multi-domain]  Cd Length: 132  Bit Score: 140.00  E-value: 9.64e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2795024587  22 RAPQSRSQRAGLQFPVGRIHRFLKKRvANNQRVGATAAVYAAAIMEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGD 101
Cdd:COG5262    14 RVSQSRSAKAGLIFPVGRVKRLLKKG-NYRMRIGAGAPVYLAAVLEYLAAEILELAGNAARDNKKKRIIPRHLQLAIRND 92

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2795024587 102 EELDTLIK-ATIAGGGVIPHIHKNLITKQNKK 132
Cdd:COG5262    93 EELNKLLGdVTIAQGGVLPNINPGLLPKSSKK 124
PLN00157 PLN00157
histone H2A; Provisional
 20-132 1.60e-37

histone H2A; Provisional


Pssm-ID: 177758  Cd Length: 132  Bit Score: 124.19  E-value: 1.60e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2795024587  20 SKRAPQSRSQRAGLQFPVGRIHRFLKK-RVAnnQRVGATAAVYAAAIMEYLTAEVLELAGNASKDLKVKRITPRHLQLAI 98
Cdd:PLN00157   12 GGKKATSRSAKAGLQFPVGRIARYLKAgKYA--TRVGAGAPVYLAAVLEYLAAEVLELAGNAARDNKKSRIVPRHIQLAV 89

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2795024587  99 RGDEELDTLIK-ATIAGGGVIPHIHKNLITKQNKK 132
Cdd:PLN00157   90 RNDEELSKLLGgVTIAAGGVLPNIHSVLLPKKSGK 124
HFD_H2A cd00074
histone-fold domain found in histone H2A and similar proteins; Histone H2A is the core ...
 25-112 1.65e-36

histone-fold domain found in histone H2A and similar proteins; Histone H2A is the core component of the nucleosome, which wraps and compacts DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.


Pssm-ID: 467020  Cd Length: 89  Bit Score: 119.95  E-value: 1.65e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2795024587  25 QSRSQRAGLQFPVGRIHRFLKKRVANnQRVGATAAVYAAAIMEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEEL 104
Cdd:cd00074     1 QSRSKRAGLQFPVGRIHRLLKKGTYA-KRVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKKRITPRHIQLAIRNDEEL 79


                  ....*...
gi 2795024587 105 DTLIKATI 112
Cdd:cd00074    80 NKLFKGVT 87
PLN00156 PLN00156
histone H2AX; Provisional
 26-132 1.09e-34

histone H2AX; Provisional


Pssm-ID: 215080  Cd Length: 139  Bit Score: 117.38  E-value: 1.09e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2795024587  26 SRSQRAGLQFPVGRIHRFLKKRvANNQRVGATAAVYAAAIMEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELD 105
Cdd:PLN00156   21 SRSSKAGLQFPVGRIARFLKAG-KYAERVGAGAPVYLSAVLEYLAAEVLELAGNAARDNKKNRIVPRHIQLAVRNDEELS 99

                          90       100
                  ....*....|....*....|....*...
gi 2795024587 106 TLIKA-TIAGGGVIPHIHKNLITKQNKK 132
Cdd:PLN00156  100 KLLGSvTIAAGGVLPNIHQTLLPKKVGK 127
PLN00153 PLN00153
histone H2A; Provisional
 19-131 1.49e-31

histone H2A; Provisional


Pssm-ID: 165721 [Multi-domain]  Cd Length: 129  Bit Score: 109.04  E-value: 1.49e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2795024587  19 TSKRAPQSRSQRAGLQFPVGRIHRFLKKRvANNQRVGATAAVYAAAIMEYLTAEVLELAGNASKDLKVKRITPRHLQLAI 98
Cdd:PLN00153    9 TSGKKAVSRSAKAGLQFPVGRIARYLKKG-KYAERIGAGAPVYLAAVLEYLTAEVLELAGNAARDNKKNRIVPRHIQLAI 87

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2795024587  99 RGDEELDTLI-KATIAGGGVIPHIHKNLITKQNK 131
Cdd:PLN00153   88 RNDEELGKLLgEVTIASGGVLPNIHAVLLPKKTK 121
PTZ00252 PTZ00252
histone H2A; Provisional
 20-129 1.06e-18

histone H2A; Provisional


Pssm-ID: 240330  Cd Length: 134  Bit Score: 76.15  E-value: 1.06e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2795024587  20 SKRAPQSRSQRAGLQFPVGRIHRFLKkRVANNQRVGATAAVYAAAIMEYLTAEVLELAGNAS--KDLKVKRITPRHLQLA 97
Cdd:PTZ00252   11 ASKSGSGRSAKAGLIFPVGRVGSLLR-RGQYARRIGASGAVYMAAVLEYLTAELLELSVKAAaqQAKKPKRLTPRTVTLA 89

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2795024587  98 IRGDEELDTLIK-ATIAGGGVIPHIHKNLITKQ 129
Cdd:PTZ00252   90 VRHDDDLGSLLKnVTLSRGGVMPSLNKALAKKH 122
Histone pfam00125
Core histone H2A/H2B/H3/H4;
21-101 1.12e-14

Core histone H2A/H2B/H3/H4;


Pssm-ID: 459682 [Multi-domain]  Cd Length: 126  Bit Score: 65.53  E-value: 1.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2795024587  21 KRAPQSRSQRAGLQFPVGRIHRFLKKRVANNQRVGATAAVYAAAIMEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRG 100
Cdd:pfam00125  46 IRKYQSSTDLLIYKLPFARVVREVVQSTKTDLRISADAVVALQEAVEDFLVELFEEANLLAIHAKRVTLTPKDIQLARRL 125


                  .
gi 2795024587 101 D 101
Cdd:pfam00125 126 R 126
Histone_H2A_C pfam16211
C-terminus of histone H2A;
102-133 1.14e-09

C-terminus of histone H2A;


Pssm-ID: 465070  Cd Length: 35  Bit Score: 50.22  E-value: 1.14e-09
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2795024587 102 EELDTLIK-ATIAGGGVIPHIHKNLITKQNKKR 133
Cdd:pfam16211   1 EELNKLLRgVTIAQGGVLPNIHKVLLPKKTKKK 33
HFD_SOS1_rpt2 cd22915
second histone-fold domain found in son of sevenless homolog 1 (SOS-1) and similar proteins; ...
 35-104 1.03e-08

second histone-fold domain found in son of sevenless homolog 1 (SOS-1) and similar proteins; SOS-1 is a guanine nucleotide exchange factor for Ras that binds to GRB2. It promotes the exchange of Ras-bound GDP by GTP. It is a catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac, by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity. SOS-1 contains tandem histone folds at the N-terminal region. The model corresponds to the second repeat.


Pssm-ID: 467040  Cd Length: 75  Bit Score: 48.77  E-value: 1.03e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2795024587  35 FPVGRIHRFLKKRVANNqRVGATAAVYAAAIMEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEEL 104
Cdd:cd22915     2 FPVDKIHPLLKKDLLVY-KVDPQVSLYLVAVLEYIAADILKLAGNYVRNIRHYEITSQDIKVAMCADKVL 70
HFD_ABTB2-like cd22913
histone-fold domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) ...
 25-104 3.19e-08

histone-fold domain found in ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; ABTB2, also called Bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, which has implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). This subfamily also includes BTB/POZ domain-containing protein 11 (BTBD11), also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11. It is a BTB-domain-containing Kelch-like protein with unknown function.


Pssm-ID: 467038  Cd Length: 105  Bit Score: 48.06  E-value: 3.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2795024587  25 QSRSQRAGLQFPVGRIHRFL-KKRVAnnQRVGATAAVYAAAIMEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEE 103
Cdd:cd22913     9 RSKSARCGLTFSVGRFHRWMvDSRLA--KRIHEHAAVYLTACMENLLEEIFLRALASLVPKGELELTVEALEYGINNDAE 86


                  .
gi 2795024587 104 L 104
Cdd:cd22913    87 L 87
PLN00155 PLN00155
histone H2A; Provisional
 19-69 3.14e-07

histone H2A; Provisional


Pssm-ID: 165723  Cd Length: 58  Bit Score: 44.70  E-value: 3.14e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2795024587  19 TSKRAPQSRSQRAGLQFPVGRIHRFLKKRvANNQRVGATAAVYAAAIMEYL 69
Cdd:PLN00155    9 TSGKKAVSRSAKAGLQFPVGRIARYLKKG-KYAERIGAGAPVYLAAVLEYL 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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