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Conserved domains on  [gi|2794956638|ref|XP_067729917|]
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uncharacterized protein MONOS_4187 [Monocercomonoides exilis]

Protein Classification

protein kinase family protein( domain architecture ID 229378)

protein kinase family protein may catalyze the transfer of the gamma-phosphoryl group from ATP to substrates such as serine/threonine and/or tyrosine residues on proteins, or may be a pseudokinase

CATH:  1.10.510.10
PubMed:  16244704
SCOP:  4003661

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PKc_like super family cl21453
Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the ...
 2420-2503 1.39e-07

Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases, and choline kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to hydroxyl groups in specific substrates such as serine, threonine, or tyrosine residues of proteins.


The actual alignment was detected with superfamily member cd13999:

Pssm-ID: 473864 [Multi-domain]  Cd Length: 245  Bit Score: 55.24  E-value: 1.39e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794956638 2420 LRWKAPELQMNKKmgATKESVAFSIGMMLWECLTLQIPFGEYE-AEVAGQKIVNGERPSMKEAEESMLLPMILSCLSSES 2498
Cdd:cd13999    155 PRWMAPEVLRGEP--YTEKADVYSFGIVLWELLTGEVPFKELSpIQIAAAVVQKGLRPPIPPDCPPELSKLIKRCWNEDP 232


                   ....*
gi 2794956638 2499 EKRLS 2503
Cdd:cd13999    233 EKRPS 237
PRK09752 super family cl32407
AIDA-I family autotransporter YfaL;
268-456 1.01e-03

AIDA-I family autotransporter YfaL;


The actual alignment was detected with superfamily member PRK09752:

Pssm-ID: 182059 [Multi-domain]  Cd Length: 1250  Bit Score: 44.66  E-value: 1.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794956638  268 GGGLYVHDNSSATLTVENSSFVKCNATST------RGGGIFA-----INIAECTVKHSVfeecfcasSTDYGGA---GAE 333
Cdd:PRK09752    76 GGAVFLQQGAEFTLSPENETGMTLFANNTvsgeynNGGAIFAkenstLNLTDVIFSGNV--------AGGYGGAiysSGT 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794956638  334 VEELKVQVLVENCLFEDGWSgNDGGGLGIWrskTINSNDCILDCIFLNCSAHYSTD--SGGGGFI--------TWYPSDK 403
Cdd:PRK09752   148 NDTGAVDLRVTNAMFRNNIA-NDGKGGAIY---TINNDVYLSDVIFDNNQAYTSTSysDGDGGAIdvtdnnsdSKHPSGY 223

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2794956638  404 IVAKNCLFQRCYSARHGGAVsvqtkeyngnllwfcFFHNNSAPQGNDIYVHDN 456
Cdd:PRK09752   224 TIINNTAFTNNTAEGYGGAI---------------YTNSATAPYLIDISVDDS 261
 
Name Accession Description Interval E-value
STKc_MAP3K-like cd13999
Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine ...
 2420-2503 1.39e-07

Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed mainly of MAP3Ks and similar proteins, including TGF-beta Activated Kinase-1 (TAK1, also called MAP3K7), MAP3K12, MAP3K13, Mixed lineage kinase (MLK), MLK-Like mitogen-activated protein Triple Kinase (MLTK), and Raf (Rapidly Accelerated Fibrosarcoma) kinases. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Also included in this subfamily is the pseudokinase Kinase Suppressor of Ras (KSR), which is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway.


Pssm-ID: 270901 [Multi-domain]  Cd Length: 245  Bit Score: 55.24  E-value: 1.39e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794956638 2420 LRWKAPELQMNKKmgATKESVAFSIGMMLWECLTLQIPFGEYE-AEVAGQKIVNGERPSMKEAEESMLLPMILSCLSSES 2498
Cdd:cd13999    155 PRWMAPEVLRGEP--YTEKADVYSFGIVLWELLTGEVPFKELSpIQIAAAVVQKGLRPPIPPDCPPELSKLIKRCWNEDP 232


                   ....*
gi 2794956638 2499 EKRLS 2503
Cdd:cd13999    233 EKRPS 237
PRK09752 PRK09752
AIDA-I family autotransporter YfaL;
268-456 1.01e-03

AIDA-I family autotransporter YfaL;


Pssm-ID: 182059 [Multi-domain]  Cd Length: 1250  Bit Score: 44.66  E-value: 1.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794956638  268 GGGLYVHDNSSATLTVENSSFVKCNATST------RGGGIFA-----INIAECTVKHSVfeecfcasSTDYGGA---GAE 333
Cdd:PRK09752    76 GGAVFLQQGAEFTLSPENETGMTLFANNTvsgeynNGGAIFAkenstLNLTDVIFSGNV--------AGGYGGAiysSGT 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794956638  334 VEELKVQVLVENCLFEDGWSgNDGGGLGIWrskTINSNDCILDCIFLNCSAHYSTD--SGGGGFI--------TWYPSDK 403
Cdd:PRK09752   148 NDTGAVDLRVTNAMFRNNIA-NDGKGGAIY---TINNDVYLSDVIFDNNQAYTSTSysDGDGGAIdvtdnnsdSKHPSGY 223

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2794956638  404 IVAKNCLFQRCYSARHGGAVsvqtkeyngnllwfcFFHNNSAPQGNDIYVHDN 456
Cdd:PRK09752   224 TIINNTAFTNNTAEGYGGAI---------------YTNSATAPYLIDISVDDS 261
 
Name Accession Description Interval E-value
STKc_MAP3K-like cd13999
Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine ...
 2420-2503 1.39e-07

Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed mainly of MAP3Ks and similar proteins, including TGF-beta Activated Kinase-1 (TAK1, also called MAP3K7), MAP3K12, MAP3K13, Mixed lineage kinase (MLK), MLK-Like mitogen-activated protein Triple Kinase (MLTK), and Raf (Rapidly Accelerated Fibrosarcoma) kinases. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Also included in this subfamily is the pseudokinase Kinase Suppressor of Ras (KSR), which is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway.


Pssm-ID: 270901 [Multi-domain]  Cd Length: 245  Bit Score: 55.24  E-value: 1.39e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794956638 2420 LRWKAPELQMNKKmgATKESVAFSIGMMLWECLTLQIPFGEYE-AEVAGQKIVNGERPSMKEAEESMLLPMILSCLSSES 2498
Cdd:cd13999    155 PRWMAPEVLRGEP--YTEKADVYSFGIVLWELLTGEVPFKELSpIQIAAAVVQKGLRPPIPPDCPPELSKLIKRCWNEDP 232


                   ....*
gi 2794956638 2499 EKRLS 2503
Cdd:cd13999    233 EKRPS 237
STKc_MLTK cd14060
Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated ...
 2422-2505 5.37e-05

Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLTK, also called zipper sterile-alpha-motif kinase (ZAK), contains a catalytic kinase domain and a leucine zipper. There are two alternatively-spliced variants, MLTK-alpha and MLTK-beta. MLTK-alpha contains a sterile-alpha-motif (SAM) at the C-terminus. MLTK regulates the c-Jun N-terminal kinase, extracellular signal-regulated kinase, p38 MAPK, and NF-kB pathways. ZAK is the MAP3K involved in the signaling cascade that leads to the ribotoxic stress response initiated by cellular damage due to Shiga toxins and ricin. It may also play a role in cell transformation and cancer development. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals.The MLTK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270962 [Multi-domain]  Cd Length: 242  Bit Score: 47.26  E-value: 5.37e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794956638 2422 WKAPELQMNKKMGATKESvaFSIGMMLWECLTLQIPFGEYEA-EVAGQKIVNGERPSMKEAEESMLLPMILSCLSSESEK 2500
Cdd:cd14060    151 WMAPEVIQSLPVSETCDT--YSYGVVLWEMLTREVPFKGLEGlQVAWLVVEKNERPTIPSSCPRSFAELMRRCWEADVKE 228


                   ....*
gi 2794956638 2501 RLSLQ 2505
Cdd:cd14060    229 RPSFK 233
PRK09752 PRK09752
AIDA-I family autotransporter YfaL;
268-456 1.01e-03

AIDA-I family autotransporter YfaL;


Pssm-ID: 182059 [Multi-domain]  Cd Length: 1250  Bit Score: 44.66  E-value: 1.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794956638  268 GGGLYVHDNSSATLTVENSSFVKCNATST------RGGGIFA-----INIAECTVKHSVfeecfcasSTDYGGA---GAE 333
Cdd:PRK09752    76 GGAVFLQQGAEFTLSPENETGMTLFANNTvsgeynNGGAIFAkenstLNLTDVIFSGNV--------AGGYGGAiysSGT 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794956638  334 VEELKVQVLVENCLFEDGWSgNDGGGLGIWrskTINSNDCILDCIFLNCSAHYSTD--SGGGGFI--------TWYPSDK 403
Cdd:PRK09752   148 NDTGAVDLRVTNAMFRNNIA-NDGKGGAIY---TINNDVYLSDVIFDNNQAYTSTSysDGDGGAIdvtdnnsdSKHPSGY 223

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2794956638  404 IVAKNCLFQRCYSARHGGAVsvqtkeyngnllwfcFFHNNSAPQGNDIYVHDN 456
Cdd:PRK09752   224 TIINNTAFTNNTAEGYGGAI---------------YTNSATAPYLIDISVDDS 261
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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