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Conserved domains on  [gi|2721090384|ref|XP_064499407|]
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cyclin-dependent kinase 4 inhibitor B-like [Pseudopipra pipra]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-155 7.12e-18

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.46  E-value: 7.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721090384  13 LANAAARGDLQRLRELLDGAADPNAVNSYGRTPIQV-MMLGSPRVAELLLQRGADPNRPDPStGCLPAHDAARAGFLETL 91
Cdd:COG0666   124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLaAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENGHLEIV 202

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2721090384  92 AALHRAGARLDQPDGRGRLPLDVAAGGPHGAVGRYLRHPPPAPDLSRGNSRPKIMLAPASGDTK 155
Cdd:COG0666   203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAAL 266
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-155 7.12e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.46  E-value: 7.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721090384  13 LANAAARGDLQRLRELLDGAADPNAVNSYGRTPIQV-MMLGSPRVAELLLQRGADPNRPDPStGCLPAHDAARAGFLETL 91
Cdd:COG0666   124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLaAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENGHLEIV 202

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2721090384  92 AALHRAGARLDQPDGRGRLPLDVAAGGPHGAVGRYLRHPPPAPDLSRGNSRPKIMLAPASGDTK 155
Cdd:COG0666   203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAAL 266
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 12-96 4.21e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.13  E-value: 4.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721090384  12 ELANAAARGDLQRLRELLDGAADPNAVNSYGRTPIQVM-MLGSPRVAELLLQRGADPNRPDpSTGCLPAHDAARAGFLET 90
Cdd:PTZ00322   85 ELCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIAcANGHVQVVRVLLEFGADPTLLD-KDGKTPLELAEENGFREV 163


                  ....*.
gi 2721090384  91 LAALHR 96
Cdd:PTZ00322  164 VQLLSR 169
Ank_2 pfam12796
Ankyrin repeats (3 copies);
13-105 1.71e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 49.34  E-value: 1.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721090384  13 LANAAARGDLQRLRELLDGAADPNAVNSYGRTPIQV-MMLGSPRVAELLLQRgADPNRPDpsTGCLPAHDAARAGFLETL 91
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLaAKNGHLEIVKLLLEH-ADVNLKD--NGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 2721090384  92 AALHRAGARLDQPD 105
Cdd:pfam12796  78 KLLLEKGADINVKD 91
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-155 7.12e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.46  E-value: 7.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721090384  13 LANAAARGDLQRLRELLDGAADPNAVNSYGRTPIQV-MMLGSPRVAELLLQRGADPNRPDPStGCLPAHDAARAGFLETL 91
Cdd:COG0666   124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLaAANGNLEIVKLLLEAGADVNARDND-GETPLHLAAENGHLEIV 202

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2721090384  92 AALHRAGARLDQPDGRGRLPLDVAAGGPHGAVGRYLRHPPPAPDLSRGNSRPKIMLAPASGDTK 155
Cdd:COG0666   203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAAL 266
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-127 1.08e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 66.90  E-value: 1.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721090384  13 LANAAARGDLQRLRELLDGAADPNAVNSYGRTP-IQVMMLGSPRVAELLLQRGADPNRPDPStGCLPAHDAARAGFLETL 91
Cdd:COG0666   157 LHLAAANGNLEIVKLLLEAGADVNARDNDGETPlHLAAENGHLEIVKLLLEAGADVNAKDND-GKTALDLAAENGNLEIV 235

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2721090384  92 AALHRAGARLDQPDGRGRLPLDVAAGGPHGAVGRYL 127
Cdd:COG0666   236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
10-127 4.91e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 62.28  E-value: 4.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721090384  10 ADELANAAARGDLQRLRELLDGAADPNAVNSYGRTP-IQVMMLGSPRVAELLLQRGADPNRPDPStGCLPAHDAARAGFL 88
Cdd:COG0666    55 ALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLlHAAARNGDLEIVKLLLEAGADVNARDKD-GETPLHLAAYNGNL 133

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2721090384  89 ETLAALHRAGARLDQPDGRGRLPLDVAAGGPHGAVGRYL 127
Cdd:COG0666   134 EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 12-96 4.21e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.13  E-value: 4.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721090384  12 ELANAAARGDLQRLRELLDGAADPNAVNSYGRTPIQVM-MLGSPRVAELLLQRGADPNRPDpSTGCLPAHDAARAGFLET 90
Cdd:PTZ00322   85 ELCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIAcANGHVQVVRVLLEFGADPTLLD-KDGKTPLELAEENGFREV 163


                  ....*.
gi 2721090384  91 LAALHR 96
Cdd:PTZ00322  164 VQLLSR 169
Ank_2 pfam12796
Ankyrin repeats (3 copies);
13-105 1.71e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 49.34  E-value: 1.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721090384  13 LANAAARGDLQRLRELLDGAADPNAVNSYGRTPIQV-MMLGSPRVAELLLQRgADPNRPDpsTGCLPAHDAARAGFLETL 91
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLaAKNGHLEIVKLLLEH-ADVNLKD--NGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 2721090384  92 AALHRAGARLDQPD 105
Cdd:pfam12796  78 KLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1-119 9.15e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 47.33  E-value: 9.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721090384   1 MARRAGGSVADELANAAaRGDLQRLRELLDGAADPNAVNSYGRTPIQVMMLGS----PRVAELLLQRGADPNRPDpSTGC 76
Cdd:PHA03095    7 VDIIMEAALYDYLLNAS-NVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSsekvKDIVRLLLEAGADVNAPE-RCGF 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2721090384  77 LPAHDAARAGF-LETLAALHRAGARLDQPDGRGRLPLDVAAGGP 119
Cdd:PHA03095   85 TPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHVYLSGF 128
PHA03095 PHA03095
ankyrin-like protein; Provisional
 25-114 4.60e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.40  E-value: 4.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721090384  25 LRELLDGAADPNAVNSYGRTPIQVMMLG---SPRVAELLLQRGADPNRPDPStGCLPAHDAARAG--FLETLAALHRAGA 99
Cdd:PHA03095  100 IKLLIKAGADVNAKDKVGRTPLHVYLSGfniNPKVIRLLLRKGADVNALDLY-GMTPLAVLLKSRnaNVELLRLLIDAGA 178

                          90
                  ....*....|....*
gi 2721090384 100 RLDQPDGRGRLPLDV 114
Cdd:PHA03095  179 DVYAVDDRFRSLLHH 193
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-127 7.40e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 44.56  E-value: 7.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721090384  13 LANAAARGDLQRLRELLDGAADPNAVNSYGRTPIQVMMLGSPRVAELLLQRGADPNRPDPSTGCLPAHDAARAGFLETLA 92
Cdd:COG0666    25 LLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVK 104

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2721090384  93 ALHRAGARLDQPDGRGRLPLDVAAGGPHGAVGRYL 127
Cdd:COG0666   105 LLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLL 139
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-112 2.94e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 42.63  E-value: 2.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721090384  13 LANAAARGDLQRLRELLDGAADPNAVNSYGRTPIQV-MMLGSPRVAELLLQRGADPNRPDPStGCLPAHDAARAGFLETL 91
Cdd:COG0666   190 LHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLaAENGNLEIVKLLLEAGADLNAKDKD-GLTALLLAAAAGAALIV 268

                          90       100
                  ....*....|....*....|.
gi 2721090384  92 AALHRAGARLDQPDGRGRLPL 112
Cdd:COG0666   269 KLLLLALLLLAAALLDLLTLL 289
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 5-66 1.40e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 41.01  E-value: 1.40e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2721090384   5 AGGsvaDELANAAARGDLQRLRELLDGAADPNAVNSYGRTPIQVMML-GSPRVAELLLQRGAD 66
Cdd:PLN03192  621 AAG---DLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAeDHVDMVRLLIMNGAD 680
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-127 1.58e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 40.74  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721090384   9 VADELANAAARGDLQRLRELLDGAADPNAV-NSYGRTPIQV-MMLGSPRVAELLLQRGADPNRP--DPSTgclPAHDAAR 84
Cdd:PHA02875   68 IESELHDAVEEGDVKAVEELLDLGKFADDVfYKDGMTPLHLaTILKKLDIMKLLIARGADPDIPntDKFS---PLHLAVM 144

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2721090384  85 AGFLETLAALHRAGARLDQPDGRGRLPLDVAAGGPHGAVGRYL 127
Cdd:PHA02875  145 MGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKML 187
Ank_4 pfam13637
Ankyrin repeats (many copies);
13-61 1.81e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 1.81e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2721090384  13 LANAAARGDLQRLRELLDGAADPNAVNSYGRTPIQ--VMMlGSPRVAELLL 61
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGADINAVDGNGETALHfaASN-GNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 12-155 5.05e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 39.20  E-value: 5.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721090384  12 ELANAAARGDLQRLRELLDGAADPNAVNSYGRTPIQVMM-LGSPRVAELLLQRGADPNRPDPSTGClPAHDAARAGFLET 90
Cdd:PHA02875    5 ALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMkFRDSEAIKLLMKHGAIPDVKYPDIES-ELHDAVEEGDVKA 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2721090384  91 LAALHRAGARLDQP-DGRGRLPLDVAAGGPHGAVGRYLRHPPPAPDLSRGNSRPKIMLAPASGDTK 155
Cdd:PHA02875   84 VEELLDLGKFADDVfYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK 149
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 55-117 1.37e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 37.94  E-value: 1.37e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2721090384  55 RVAELLLQRGADPNRPDpSTGCLPAHDAARAGFLETLAALHRAGARLDQPDGRGRLPLDVAAG 117
Cdd:PHA02878  182 RLTELLLSYGANVNIPD-KTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVG 243
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 41-71 2.78e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 33.80  E-value: 2.78e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2721090384  41 YGRTPIQ--VMMLGSPRVAELLLQRGADPNRPD 71
Cdd:pfam00023   1 DGNTPLHlaAGRRGNLEIVKLLLSKGADVNARD 33
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 25-116 3.08e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 36.87  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721090384  25 LRELLDGAADPNAVNSYGRTPIQ-VMMLGSPRVAELLLQRGADPNRPDpSTGCLPAHDAARAGFLETLAALHRAGARLDQ 103
Cdd:PHA02874  107 IKTILDCGIDVNIKDAELKTFLHyAIKKGDLESIKMLFEYGADVNIED-DNGCYPIHIAIKHNFFDIIKLLLEKGAYANV 185

                          90
                  ....*....|...
gi 2721090384 104 PDGRGRLPLDVAA 116
Cdd:PHA02874  186 KDNNGESPLHNAA 198
PHA03095 PHA03095
ankyrin-like protein; Provisional
 25-114 5.71e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 36.16  E-value: 5.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2721090384  25 LRELLDGAADPNAVNSYGRTPIQVMMLGS--PRVAELLLQRGADPNRPD-----PSTGCLpAHDAARAGfleTLAALHRA 97
Cdd:PHA03095   66 VRLLLEAGADVNAPERCGFTPLHLYLYNAttLDVIKLLIKAGADVNAKDkvgrtPLHVYL-SGFNINPK---VIRLLLRK 141

                          90
                  ....*....|....*..
gi 2721090384  98 GARLDQPDGRGRLPLDV 114
Cdd:PHA03095  142 GADVNALDLYGMTPLAV 158
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 28-68 8.97e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 35.81  E-value: 8.97e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2721090384  28 LLDGAADPNAVNSYGRTPIQ-VMMLGSPRVAELLLQRGADPN 68
Cdd:PHA02876  164 LLEGGADVNAKDIYCITPIHyAAERGNAKMVNLLLSYGADVN 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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