NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2587643768|ref|XP_059732538|]
View 

ribosome biogenesis protein NOP53 isoform X1 [Bos taurus]

Protein Classification

ribosome biogenesis protein NOP53( domain architecture ID 12083027)

ribosome biogenesis protein NOP53 is a nucleolar protein which is involved in the regulation of several cell functions, including integration of 5S RNP into ribosomal large subunit, ribosome biogenesis, sensor-regulating the activation of p53/TP53 in response to stress conditions, and tumor suppression.

Gene Ontology:  GO:0000027|GO:0006364

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Nop53 pfam07767
Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ...
 48-451 1.76e-83

Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ribosomal biogenesis. They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation. This family contains sequences that bear similarity to the glioma tumour suppressor candidate region gene 2 protein (p60). This protein has been found to interact with herpes simplex type 1 regulatory proteins.


:

Pssm-ID: 462259 [Multi-domain]  Cd Length: 353  Bit Score: 261.85  E-value: 1.76e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2587643768  48 WRRLAQEPlglEVDQFLEDVRLQERTsGGLISEAPDEKLFFVDTGFKDKELNKKRTKgqkrsllLKKPLRSDLILENTSK 127
Cdd:pfam07767   8 WRKNIDIT---DVEDGLEEVREEIIT-GGVLSEKPDDELFVVDTKGDEELKKKLRKK-------IKKPLKSDEILAQRSA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2587643768 128 VPvpkDVLAHQ-VPNARKLKRKEQLWERLAKQGKLPGEVRRAQArllnppaATAKPGPQDTVQRPFYDLWAKGNPLDRPL 206
Cdd:pfam07767  77 VP---AVSHKRkRPGAKKLKKKKVSKKELARLRKLAKGKRKGEK-------KLEKSAKDGLVFSGTYDLWGEEEEPEVEK 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2587643768 207 EGQDEFFLEQTKKKGVKRPQHLHTKP---SRVPAVEVTPAGASYNPAFEDHQNLLWAAHEVELQREKAAEKLERQLAlPA 283
Cdd:pfam07767 147 KEEEHTLSFLEKKKKVKAPKTLKHKPislTALPAVEVPHAGTSYNPSFEDHQELLQKAVEAEKKRLKEEEKLERVLE-KI 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2587643768 284 SEQAATQESAFRemcqglleesdgegepgegqdegpeagdpaargeaspvpgrpaalEKKTEQQRRREKAARMLRMQQAA 363
Cdd:pfam07767 226 AESAATAEAREE---------------------------------------------KRKTKAQRNKEKRRKEEEREAKE 260

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2587643768 364 VRATRLRHQELFRLRGIKAQVA-----RRLAELARRREQRKAKRLAEADKPRRLGRLKYQDPDIDVQLSSELSDSLRTLK 438
Cdd:pfam07767 261 EKALKKKLAQLERLKEIAKEIAekekeREEKAEARKREKRKKKKEEKKLRPRKLGKHKVPEPDLEVQLPDELSGSLRLLK 340

                         410
                  ....*....|...
gi 2587643768 439 PEGNILRDRFKSF 451
Cdd:pfam07767 341 PEGNLLKDRFKSL 353
 
Name Accession Description Interval E-value
Nop53 pfam07767
Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ...
 48-451 1.76e-83

Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ribosomal biogenesis. They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation. This family contains sequences that bear similarity to the glioma tumour suppressor candidate region gene 2 protein (p60). This protein has been found to interact with herpes simplex type 1 regulatory proteins.


Pssm-ID: 462259 [Multi-domain]  Cd Length: 353  Bit Score: 261.85  E-value: 1.76e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2587643768  48 WRRLAQEPlglEVDQFLEDVRLQERTsGGLISEAPDEKLFFVDTGFKDKELNKKRTKgqkrsllLKKPLRSDLILENTSK 127
Cdd:pfam07767   8 WRKNIDIT---DVEDGLEEVREEIIT-GGVLSEKPDDELFVVDTKGDEELKKKLRKK-------IKKPLKSDEILAQRSA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2587643768 128 VPvpkDVLAHQ-VPNARKLKRKEQLWERLAKQGKLPGEVRRAQArllnppaATAKPGPQDTVQRPFYDLWAKGNPLDRPL 206
Cdd:pfam07767  77 VP---AVSHKRkRPGAKKLKKKKVSKKELARLRKLAKGKRKGEK-------KLEKSAKDGLVFSGTYDLWGEEEEPEVEK 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2587643768 207 EGQDEFFLEQTKKKGVKRPQHLHTKP---SRVPAVEVTPAGASYNPAFEDHQNLLWAAHEVELQREKAAEKLERQLAlPA 283
Cdd:pfam07767 147 KEEEHTLSFLEKKKKVKAPKTLKHKPislTALPAVEVPHAGTSYNPSFEDHQELLQKAVEAEKKRLKEEEKLERVLE-KI 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2587643768 284 SEQAATQESAFRemcqglleesdgegepgegqdegpeagdpaargeaspvpgrpaalEKKTEQQRRREKAARMLRMQQAA 363
Cdd:pfam07767 226 AESAATAEAREE---------------------------------------------KRKTKAQRNKEKRRKEEEREAKE 260

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2587643768 364 VRATRLRHQELFRLRGIKAQVA-----RRLAELARRREQRKAKRLAEADKPRRLGRLKYQDPDIDVQLSSELSDSLRTLK 438
Cdd:pfam07767 261 EKALKKKLAQLERLKEIAKEIAekekeREEKAEARKREKRKKKKEEKKLRPRKLGKHKVPEPDLEVQLPDELSGSLRLLK 340

                         410
                  ....*....|...
gi 2587643768 439 PEGNILRDRFKSF 451
Cdd:pfam07767 341 PEGNLLKDRFKSL 353
 
Name Accession Description Interval E-value
Nop53 pfam07767
Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ...
 48-451 1.76e-83

Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ribosomal biogenesis. They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation. This family contains sequences that bear similarity to the glioma tumour suppressor candidate region gene 2 protein (p60). This protein has been found to interact with herpes simplex type 1 regulatory proteins.


Pssm-ID: 462259 [Multi-domain]  Cd Length: 353  Bit Score: 261.85  E-value: 1.76e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2587643768  48 WRRLAQEPlglEVDQFLEDVRLQERTsGGLISEAPDEKLFFVDTGFKDKELNKKRTKgqkrsllLKKPLRSDLILENTSK 127
Cdd:pfam07767   8 WRKNIDIT---DVEDGLEEVREEIIT-GGVLSEKPDDELFVVDTKGDEELKKKLRKK-------IKKPLKSDEILAQRSA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2587643768 128 VPvpkDVLAHQ-VPNARKLKRKEQLWERLAKQGKLPGEVRRAQArllnppaATAKPGPQDTVQRPFYDLWAKGNPLDRPL 206
Cdd:pfam07767  77 VP---AVSHKRkRPGAKKLKKKKVSKKELARLRKLAKGKRKGEK-------KLEKSAKDGLVFSGTYDLWGEEEEPEVEK 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2587643768 207 EGQDEFFLEQTKKKGVKRPQHLHTKP---SRVPAVEVTPAGASYNPAFEDHQNLLWAAHEVELQREKAAEKLERQLAlPA 283
Cdd:pfam07767 147 KEEEHTLSFLEKKKKVKAPKTLKHKPislTALPAVEVPHAGTSYNPSFEDHQELLQKAVEAEKKRLKEEEKLERVLE-KI 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2587643768 284 SEQAATQESAFRemcqglleesdgegepgegqdegpeagdpaargeaspvpgrpaalEKKTEQQRRREKAARMLRMQQAA 363
Cdd:pfam07767 226 AESAATAEAREE---------------------------------------------KRKTKAQRNKEKRRKEEEREAKE 260

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2587643768 364 VRATRLRHQELFRLRGIKAQVA-----RRLAELARRREQRKAKRLAEADKPRRLGRLKYQDPDIDVQLSSELSDSLRTLK 438
Cdd:pfam07767 261 EKALKKKLAQLERLKEIAKEIAekekeREEKAEARKREKRKKKKEEKKLRPRKLGKHKVPEPDLEVQLPDELSGSLRLLK 340

                         410
                  ....*....|...
gi 2587643768 439 PEGNILRDRFKSF 451
Cdd:pfam07767 341 PEGNLLKDRFKSL 353
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH