Domain of unknown function (DUF3371); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 125 to 142 amino acids in length.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558970734 231 IQARAHGLPSMAAS-MGAVELSSHLLKQQQQHQPGTPAPPstqappqpgqppiyppeDMSNPEytqrTPLPAAMVAGNAG 309
Cdd:pfam11851   1 MQARAHGLPVASSSgLCTAELAARVIKQEPALPPCPPDLY-----------------DMSQPQ----PPTQAAVSSSSTL 59

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2558970734 310 EQTDGSNTYSdplshFTDF---FCSTLKEEHRLDEILMDDPLSPFG-TDPLLSAGSPAASKGSSHRSSFSSDE 378
Cdd:pfam11851  60 DLNDGLITFS-----FGDLsasFSDALKPGSKLDDILMDDTLSPLGpSDPLLSAMSPDASKDSSRRSSFSMEE 127

Domain of unknown function (DUF3371); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 125 to 142 amino acids in length.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558970734 231 IQARAHGLPSMAAS-MGAVELSSHLLKQQQQHQPGTPAPPstqappqpgqppiyppeDMSNPEytqrTPLPAAMVAGNAG 309
Cdd:pfam11851   1 MQARAHGLPVASSSgLCTAELAARVIKQEPALPPCPPDLY-----------------DMSQPQ----PPTQAAVSSSSTL 59

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2558970734 310 EQTDGSNTYSdplshFTDF---FCSTLKEEHRLDEILMDDPLSPFG-TDPLLSAGSPAASKGSSHRSSFSSDE 378
Cdd:pfam11851  60 DLNDGLITFS-----FGDLsasFSDALKPGSKLDDILMDDTLSPLGpSDPLLSAMSPDASKDSSRRSSFSMEE 127

helix loop helix domain;

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2558970734  151 NLIERRRRYNINYRIKELGTLIPkSNDPDMRWNKGTILKASVEYIKWLQKEQQ 203
Cdd:smart00353   1 NARERRRRRKINEAFDELRSLLP-TLPKNKKLSKAEILRLAIEYIKSLQEELQ 52

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins; MITF, also termed Class E basic helix-loop-helix protein 32 (bHLHe32), is a bHLHzip transcription factor that is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. It regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. It binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558970734 134 EHDTRVLAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQHARDLESRQK 213
Cdd:cd18926     1 ESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKELENRQK 80

                          90       100
                  ....*....|....*....|....
gi 2558970734 214 KLEQANRRLLLRIQELEIQARAHG 237
Cdd:cd18926    81 KLEHANRHLLLRIQELEMQARAHG 104

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins; TFEB, also termed Class E basic helix-loop-helix protein 35 (bHLHe35), is a bHLHzip transcription factor that is required for vascularization of the mouse placenta. It specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Its efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558970734 136 DTRVLAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQHARDLESRQKKL 215
Cdd:cd18927     1 EARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKTNDLDVRWNKGTILKASVDYIKRMQKDLQRSRELENHSRRL 80

                          90
                  ....*....|.
gi 2558970734 216 EQANRRLLLRI 226
Cdd:cd18927    81 EMTNKQLWLRI 91

Domain of unknown function (DUF3371); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 125 to 142 amino acids in length.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558970734 231 IQARAHGLPSMAAS-MGAVELSSHLLKQQQQHQPGTPAPPstqappqpgqppiyppeDMSNPEytqrTPLPAAMVAGNAG 309
Cdd:pfam11851   1 MQARAHGLPVASSSgLCTAELAARVIKQEPALPPCPPDLY-----------------DMSQPQ----PPTQAAVSSSSTL 59

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2558970734 310 EQTDGSNTYSdplshFTDF---FCSTLKEEHRLDEILMDDPLSPFG-TDPLLSAGSPAASKGSSHRSSFSSDE 378
Cdd:pfam11851  60 DLNDGLITFS-----FGDLsasFSDALKPGSKLDDILMDDTLSPLGpSDPLLSAMSPDASKDSSRRSSFSMEE 127

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream stimulatory factor)/MITF (microphthalmia-associated transcription factor) family includes two bHLHzip transcription factor subfamilies. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements. The MITF (also known as microphthalmia-TFE, or MiT) subfamily comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF subfamily proteins can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2558970734 149 NHNLIERRRRYNINYRIKELGTLIPKSND--PDMRWNKGTILKASVEYIKWLQKEQQ 203
Cdd:cd11387     1 SHNAVERRRRDNINEKIQELGSLVPPSRLetKDLKPNKGSILSKAVEYIRELQNQNQ 57

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558970734 142 KERQKKDNHNLIERRRRYNINYRIKELGTLIPKsndPDMRWNKGTILKASVEYIKWLQKEQQhardlesrqkKLEQANRR 221
Cdd:cd11394     2 PKVEKRSAHNAIEKRYRSSINDRIIELKDLVVG---PDAKMNKSAVLRKAIDYIRYLQKVNQ----------KLKQENMA 68

                  .
gi 2558970734 222 L 222
Cdd:cd11394    69 L 69

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 1 (SREBP1) and similar proteins; SREBP1, also termed Class D basic helix-loop-helix protein 1 (bHLHd1), or sterol regulatory element-binding transcription factor 1 (SREBF1), is a member of a family of bHLHzip transcription factors that recognize sterol regulatory element 1 (SRE-1). It acts as a transcriptional activator required for lipid homeostasis. It may control transcription of the low-density lipoprotein receptor gene as well as the fatty acid. SREBP1 has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558970734 145 QKKDNHNLIERRRRYNINYRIKELGTLIPksnDPDMRWNKGTILKASVEYIKWLQKEQQhardlesrqkKLEQANRRLLL 224
Cdd:cd18921     5 EKRTAHNAIEKRYRSSINDKIIELKDLVV---GTEAKLNKSAVLRKAIDYIRFLQQSNQ----------KLKQENMALKM 71

                  ....
gi 2558970734 225 RIQE 228
Cdd:cd18921    72 AVQK 75

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2558970734 146 KKDNHNLIERRRRYNINYRIKELGTLIP--KSNDpdmRWNKGTILKASVEYIKWLQKEQqhaRDLESRQKKLEQANRRLL 223
Cdd:cd11400     1 KRRLHNVLERQRRNDLKNSFEKLRDLVPelADNE---KASKVVILKKATEYIKQLQQEE---KKLEKEKDKLKARNEQLR 74

                  ....*.
gi 2558970734 224 LRIQEL 229
Cdd:cd11400    75 KKLERL 80