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Conserved domains on  [gi|2487110522|ref|XP_054941693|]
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LOW QUALITY PROTEIN: WD repeat-containing protein 82-like [Physeter catodon]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-296 1.45e-35

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.73  E-value: 1.45e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522  12 HVAKVFRENLDKINCFDFSPNGETVISSSDDDSLVLCDCQEGKPKRTLYSKKYGVdlircshaaNTVVYSPNKT------ 85
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV---------TSVAFSPDGKllasgs 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522  86 -DDTISYLSFHDEKYIRYFPGHSKRVVALSMSPVDDTFISGSLHKTIRLWDLQSPNCQGLMHLQGKPVCS--FDPEGLIL 162
Cdd:COG2319   182 dDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSvaFSPDGRLL 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522 163 TAGVSSEMVKLYDLRSFDkgPFATFKMQYDRTcewTGVKFSNDGKLILISTNGSFIRLIDAVKRVVMHTFGGYASSkavT 242
Cdd:COG2319   262 ASGSADGTVRLWDLATGE--LLRTLTGHSGGV---NSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA---V 333

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2487110522 243 LEASFTPESQFIMIGTEDGKIHAWNGESGIKVAVKVAvlddkHTGPITCLQVNP 296
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG-----HTGAVTSVAFSP 382
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-296 1.45e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.73  E-value: 1.45e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522  12 HVAKVFRENLDKINCFDFSPNGETVISSSDDDSLVLCDCQEGKPKRTLYSKKYGVdlircshaaNTVVYSPNKT------ 85
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV---------TSVAFSPDGKllasgs 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522  86 -DDTISYLSFHDEKYIRYFPGHSKRVVALSMSPVDDTFISGSLHKTIRLWDLQSPNCQGLMHLQGKPVCS--FDPEGLIL 162
Cdd:COG2319   182 dDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSvaFSPDGRLL 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522 163 TAGVSSEMVKLYDLRSFDkgPFATFKMQYDRTcewTGVKFSNDGKLILISTNGSFIRLIDAVKRVVMHTFGGYASSkavT 242
Cdd:COG2319   262 ASGSADGTVRLWDLATGE--LLRTLTGHSGGV---NSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA---V 333

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2487110522 243 LEASFTPESQFIMIGTEDGKIHAWNGESGIKVAVKVAvlddkHTGPITCLQVNP 296
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG-----HTGAVTSVAFSP 382
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-304 3.97e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.99  E-value: 3.97e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522  15 KVFRENLDKINCFDFSPNGETVISSSDDDSLVLCDCQEGKPKRTLYSKKYGVDLIRCSHAANTVVYSpnKTDDTISYLSF 94
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASG--SSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522  95 HDEKYIRYFPGHSKRVVALSMSPVDDTFISGSLHKTIRLWDLQSPNCQGLMHLQGKPV--CSFDPEGLILTAGVSSEMVK 172
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVnsVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522 173 LYDLRSFdkGPFATFKmqyDRTCEWTGVKFSNDGKLILISTNGSFIRLIDAVKRVVMHTFGGyaSSKAVTlEASFTPESQ 252
Cdd:cd00200   161 LWDLRTG--KCVATLT---GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG--HENGVN-SVAFSPDGY 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2487110522 253 FIMIGTEDGKIHAWNGESGIKVAVKVAvlddkHTGPITCLQVNPKFMTFAGA 304
Cdd:cd00200   233 LLASGSEDGTIRVWDLRTGECVQTLSG-----HTNSVTSLAWSPDGKRLASG 279
WD40 pfam00400
WD domain, G-beta repeat;
98-135 2.51e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 2.51e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2487110522  98 KYIRYFPGHSKRVVALSMSPVDDTFISGSLHKTIRLWD 135
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-135 5.26e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 5.26e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2487110522   98 KYIRYFPGHSKRVVALSMSPVDDTFISGSLHKTIRLWD 135
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
12-296 1.45e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.73  E-value: 1.45e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522  12 HVAKVFRENLDKINCFDFSPNGETVISSSDDDSLVLCDCQEGKPKRTLYSKKYGVdlircshaaNTVVYSPNKT------ 85
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV---------TSVAFSPDGKllasgs 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522  86 -DDTISYLSFHDEKYIRYFPGHSKRVVALSMSPVDDTFISGSLHKTIRLWDLQSPNCQGLMHLQGKPVCS--FDPEGLIL 162
Cdd:COG2319   182 dDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSvaFSPDGRLL 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522 163 TAGVSSEMVKLYDLRSFDkgPFATFKMQYDRTcewTGVKFSNDGKLILISTNGSFIRLIDAVKRVVMHTFGGYASSkavT 242
Cdd:COG2319   262 ASGSADGTVRLWDLATGE--LLRTLTGHSGGV---NSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA---V 333

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2487110522 243 LEASFTPESQFIMIGTEDGKIHAWNGESGIKVAVKVAvlddkHTGPITCLQVNP 296
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG-----HTGAVTSVAFSP 382
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-304 3.97e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.99  E-value: 3.97e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522  15 KVFRENLDKINCFDFSPNGETVISSSDDDSLVLCDCQEGKPKRTLYSKKYGVDLIRCSHAANTVVYSpnKTDDTISYLSF 94
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASG--SSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522  95 HDEKYIRYFPGHSKRVVALSMSPVDDTFISGSLHKTIRLWDLQSPNCQGLMHLQGKPV--CSFDPEGLILTAGVSSEMVK 172
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVnsVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522 173 LYDLRSFdkGPFATFKmqyDRTCEWTGVKFSNDGKLILISTNGSFIRLIDAVKRVVMHTFGGyaSSKAVTlEASFTPESQ 252
Cdd:cd00200   161 LWDLRTG--KCVATLT---GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG--HENGVN-SVAFSPDGY 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2487110522 253 FIMIGTEDGKIHAWNGESGIKVAVKVAvlddkHTGPITCLQVNPKFMTFAGA 304
Cdd:cd00200   233 LLASGSEDGTIRVWDLRTGECVQTLSG-----HTNSVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
15-267 2.13e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.17  E-value: 2.13e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522  15 KVFRENLDKINCFDFSPNGETVISSSDDDSLVLCDCQEGKPKRTLYSKKYGVdlircshaaNTVVYSPN-KT------DD 87
Cdd:COG2319   156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV---------RSVAFSPDgKLlasgsaDG 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522  88 TISYLSFHDEKYIRYFPGHSKRVVALSMSPVDDTFISGSLHKTIRLWDLQSPNCQGLMHLQGKPVCS--FDPEGLILTAG 165
Cdd:COG2319   227 TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSvaFSPDGKLLASG 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522 166 VSSEMVKLYDLRSFDkgPFATFKmqyDRTCEWTGVKFSNDGKLILISTNGSFIRLIDAVKRVVMHTFGGYasSKAVTlEA 245
Cdd:COG2319   307 SDDGTVRLWDLATGK--LLRTLT---GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH--TGAVT-SV 378

                         250       260
                  ....*....|....*....|..
gi 2487110522 246 SFTPESQFIMIGTEDGKIHAWN 267
Cdd:COG2319   379 AFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
28-296 1.40e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.60  E-value: 1.40e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522  28 DFSPNGETVISSSDDDSLVLCDCQEGKPKRTLYSKKYGVDLIRCSHAANTVVYSPNktDDTISYLSFHDEKYIRYFPGHS 107
Cdd:COG2319    43 AASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASA--DGTVRLWDLATGLLLRTLTGHT 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522 108 KRVVALSMSPVDDTFISGSLHKTIRLWDLQSPNCQGLMHLQGKPVCS--FDPEGLILTAGVSSEMVKLYDLRSFDkgPFA 185
Cdd:COG2319   121 GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSvaFSPDGKLLASGSDDGTVRLWDLATGK--LLR 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522 186 TFKmqyDRTCEWTGVKFSNDGKLILISTNGSFIRLIDAVKRVVMHTFGGYASS-KAVtleaSFTPESQFIMIGTEDGKIH 264
Cdd:COG2319   199 TLT---GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSvRSV----AFSPDGRLLASGSADGTVR 271

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2487110522 265 AWNGESGikvavKVAVLDDKHTGPITCLQVNP 296
Cdd:COG2319   272 LWDLATG-----ELLRTLTGHSGGVNSVAFSP 298
WD40 COG2319
WD40 repeat [General function prediction only];
15-223 5.54e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.36  E-value: 5.54e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522  15 KVFRENLDKINCFDFSPNGETVISSSDDDSLVLCDCQEGKPKRTLYSKKYGVdlircshaaNTVVYSPN-KT------DD 87
Cdd:COG2319   198 RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV---------RSVAFSPDgRLlasgsaDG 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522  88 TISYLSFHDEKYIRYFPGHSKRVVALSMSPVDDTFISGSLHKTIRLWDLQSPNCQGLMHLQGKPVCS--FDPEGLILTAG 165
Cdd:COG2319   269 TVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSvaFSPDGKTLASG 348

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2487110522 166 VSSEMVKLYDLRSfdKGPFATFKmqyDRTCEWTGVKFSNDGKLILISTNGSFIRLIDA 223
Cdd:COG2319   349 SDDGTVRLWDLAT--GELLRTLT---GHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-220 7.40e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.00  E-value: 7.40e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522   8 LRNFHVAKVFRENLDKINCFDFSPNGETVISSSDDDSLVLCDCQEGKPKRTLYSKKYGVDLIRCSHAANTVVYSpnKTDD 87
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASS--SQDG 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522  88 TISYLSFHDEKYIRYFPGHSKRVVALSMSPVDDTFISGSLHKTIRLWDLQSPNCQGLMHLQGKPVCS--FDPEGLILTAG 165
Cdd:cd00200   158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSvaFSPDGYLLASG 237

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2487110522 166 VSSEMVKLYDLRSFDkgPFATFKMqYDRTCewTGVKFSNDGKLILISTNGSFIRL 220
Cdd:cd00200   238 SEDGTIRVWDLRTGE--CVQTLSG-HTNSV--TSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 100-312 6.41e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.60  E-value: 6.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522 100 IRYFPGHSKRVVALSMSPVDDTFISGSLHKTIRLWDLQSPNCQGLM--HLQGKPVCSFDPEG-LILTAGVSSeMVKLYDL 176
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkgHTGPVRDVAASADGtYLASGSSDK-TIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522 177 RSFDKgpFATFKMQydrTCEWTGVKFSNDGKLILISTNGSFIRLIDAVKRVVMHTFGGYASS-KAVtleaSFTPESQFIM 255
Cdd:cd00200    81 ETGEC--VRTLTGH---TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWvNSV----AFSPDGTFVA 151

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2487110522 256 IGTEDGKIHAWNGESGikvaVKVAVLDDkHTGPITCLQVNPKFMTFAGACSNMA*WL 312
Cdd:cd00200   152 SSSQDGTIKLWDLRTG----KCVATLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
15-138 1.28e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 1.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522  15 KVFRENLDKINCFDFSPNGETVISSSDDDSLVLCDCQEGKPKRTLYSKKYGVdlircshaaNTVVYSPNKT-------DD 87
Cdd:COG2319   282 RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV---------RSVAFSPDGKtlasgsdDG 352

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2487110522  88 TISYLSFHDEKYIRYFPGHSKRVVALSMSPVDDTFISGSLHKTIRLWDLQS 138
Cdd:COG2319   353 TVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-135 8.93e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.44  E-value: 8.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2487110522   8 LRNFHVAKVFRENLDKINCFDFSPNGETVISSSDDDSLVLCDCQEGKPKRTLYSKKYGVdlircshaaNTVVYSPNK--- 84
Cdd:cd00200   164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGV---------NSVAFSPDGyll 234

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2487110522  85 ----TDDTISYLSFHDEKYIRYFPGHSKRVVALSMSPVDDTFISGSLHKTIRLWD 135
Cdd:cd00200   235 asgsEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
98-135 2.51e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 2.51e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2487110522  98 KYIRYFPGHSKRVVALSMSPVDDTFISGSLHKTIRLWD 135
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-135 5.26e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 5.26e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2487110522   98 KYIRYFPGHSKRVVALSMSPVDDTFISGSLHKTIRLWD 135
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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