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Conserved domains on  [gi|2463422910|ref|XP_054301960|]
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nuclear pore complex-interacting protein family member A7 isoform X6 [Pongo pygmaeus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NPIP super family cl05750
Nuclear pore complex interacting protein (NPIP); This family consists of a series of primate ...
 23-248 1.30e-34

Nuclear pore complex interacting protein (NPIP); This family consists of a series of primate specific nuclear pore complex interacting protein (NPIP) sequences. The function of this family is unknown but is well conserved from African apes to humans.


The actual alignment was detected with superfamily member pfam06409:

Pssm-ID: 461900 [Multi-domain]  Cd Length: 267  Bit Score: 131.79  E-value: 1.30e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  23 VSFLKTVLKSQNVHDGSTDVQRKAWRSNSHSQEGIKIGLEDLFTSQRHMEAKVRAEVHK--VTRNVNSHYKINGHRKTAK 100
Cdd:pfam06409  65 QRALKSIFPRQEGHDGSLDDIFRARRQNERKQEAIICKLEDIFKLNRHDEIKGKAKIAKehLRKKSMKEDEHGEKEKQAK 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910 101 ---------------KKKLFQRMQELRRRAQDYYRCKITPSARKPLANslcaqalqrgkaERKAAYKQHRcqmrqkkrvp 165
Cdd:pfam06409 145 eaeekgkldekehgeKEEMFQEAEALGKLAEDEIHCKIEMFARAPACN------------RRAEAAAECK---------- 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910 166 erhmsqepvqgrlglenpfsmdsgpHSVPMRNsngvPAENTektkVRMVAVEHHHSSGLRYRPYLPAETLRKRIGRKPPP 245
Cdd:pfam06409 203 -------------------------HSPGAPK----PLCLR----AEMAAAEHGHQPGLPTQPHLIADNLKNLKGHPECL 249


                  ...
gi 2463422910 246 PIQ 248
Cdd:pfam06409 250 LTP 252
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 227-569 7.94e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 7.94e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  227 RPYLPAETLRKRIGRKPPPPIQCDLRGQPRPSVKGCLRPLTLSRLQCPLGPQPHS-----------TTDDFLRRETPQDE 295
Cdd:PHA03247  2576 RPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSpspaanepdphPPPTVPPPERPRDD 2655

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  296 CALGPDPLPR----ADDFPRLKTPPEGLFIPISPSPVDDSLSLKTPPEcllVPLPPSPVDDFLTPQAPPIKRRRLGPVAF 371
Cdd:PHA03247  2656 PAPGRVSRPRrarrLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPP---PPPTPEPAPHALVSATPLPPGPAAARQAS 2732

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  372 PRADDFRRPKEPPDCFFARLPPSPVDDSLSLKTPPEcllvPLPPPVDDFLTPQAPPIKRRRLGPVAFPRADDLRRPKEPP 451
Cdd:PHA03247  2733 PALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA----PAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPP 2808

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  452 DCFFVPLPPSPVDDSLSPKTPPECLLVPLPPPvddfLTPQAPPIKRRRLGPVAflRADDFRR-------------PKEPP 518
Cdd:PHA03247  2809 AAVLAPAAALPPAASPAGPLPPPTSAQPTAPP----PPPGPPPPSLPLGGSVA--PGGDVRRrppsrspaakpaaPARPP 2882

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2463422910  519 DCFFARLPPSPVDDSLSLKTPPECLLVPLPPPVDDFLTPQAPPIKRRRLGP 569
Cdd:PHA03247  2883 VRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPP 2933
 
Name Accession Description Interval E-value
NPIP pfam06409
Nuclear pore complex interacting protein (NPIP); This family consists of a series of primate ...
 23-248 1.30e-34

Nuclear pore complex interacting protein (NPIP); This family consists of a series of primate specific nuclear pore complex interacting protein (NPIP) sequences. The function of this family is unknown but is well conserved from African apes to humans.


Pssm-ID: 461900 [Multi-domain]  Cd Length: 267  Bit Score: 131.79  E-value: 1.30e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  23 VSFLKTVLKSQNVHDGSTDVQRKAWRSNSHSQEGIKIGLEDLFTSQRHMEAKVRAEVHK--VTRNVNSHYKINGHRKTAK 100
Cdd:pfam06409  65 QRALKSIFPRQEGHDGSLDDIFRARRQNERKQEAIICKLEDIFKLNRHDEIKGKAKIAKehLRKKSMKEDEHGEKEKQAK 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910 101 ---------------KKKLFQRMQELRRRAQDYYRCKITPSARKPLANslcaqalqrgkaERKAAYKQHRcqmrqkkrvp 165
Cdd:pfam06409 145 eaeekgkldekehgeKEEMFQEAEALGKLAEDEIHCKIEMFARAPACN------------RRAEAAAECK---------- 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910 166 erhmsqepvqgrlglenpfsmdsgpHSVPMRNsngvPAENTektkVRMVAVEHHHSSGLRYRPYLPAETLRKRIGRKPPP 245
Cdd:pfam06409 203 -------------------------HSPGAPK----PLCLR----AEMAAAEHGHQPGLPTQPHLIADNLKNLKGHPECL 249


                  ...
gi 2463422910 246 PIQ 248
Cdd:pfam06409 250 LTP 252
PHA03247 PHA03247
large tegument protein UL36; Provisional
 227-569 7.94e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 7.94e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  227 RPYLPAETLRKRIGRKPPPPIQCDLRGQPRPSVKGCLRPLTLSRLQCPLGPQPHS-----------TTDDFLRRETPQDE 295
Cdd:PHA03247  2576 RPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSpspaanepdphPPPTVPPPERPRDD 2655

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  296 CALGPDPLPR----ADDFPRLKTPPEGLFIPISPSPVDDSLSLKTPPEcllVPLPPSPVDDFLTPQAPPIKRRRLGPVAF 371
Cdd:PHA03247  2656 PAPGRVSRPRrarrLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPP---PPPTPEPAPHALVSATPLPPGPAAARQAS 2732

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  372 PRADDFRRPKEPPDCFFARLPPSPVDDSLSLKTPPEcllvPLPPPVDDFLTPQAPPIKRRRLGPVAFPRADDLRRPKEPP 451
Cdd:PHA03247  2733 PALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA----PAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPP 2808

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  452 DCFFVPLPPSPVDDSLSPKTPPECLLVPLPPPvddfLTPQAPPIKRRRLGPVAflRADDFRR-------------PKEPP 518
Cdd:PHA03247  2809 AAVLAPAAALPPAASPAGPLPPPTSAQPTAPP----PPPGPPPPSLPLGGSVA--PGGDVRRrppsrspaakpaaPARPP 2882

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2463422910  519 DCFFARLPPSPVDDSLSLKTPPECLLVPLPPPVDDFLTPQAPPIKRRRLGP 569
Cdd:PHA03247  2883 VRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPP 2933
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 157-518 9.79e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 9.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910 157 QMRQKKRVPERHMSQEPVQGRLGLENPFSMDSG--PHSVPMRNSNGVPAENTEKTKVRMVAVEHH--HSSGLRYRPYLPA 232
Cdd:pfam03154 165 QILQTQPPVLQAQSGAASPPSPPPPGTTQAATAgpTPSAPSVPPQGSPATSQPPNQTQSTAAPHTliQQTPTLHPQRLPS 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910 233 ETLRKRIGRKPPPPIQCDLRGQPRPSVKGCLRPLTL------SRLQCPLGPQPHSTTDdflrrETPQDECALGPDPLPRA 306
Cdd:pfam03154 245 PHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHslqtgpSHMQHPVPPQPFPLTP-----QSSQSQVPPGPSPAAPG 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910 307 DDFPRLKTPPEGLFIPISPSPVDDSLSLKTPPECLLVPLPPSPVDDFLTPQAPPIKRRRLGPVAFPRADDFRRPK--EPP 384
Cdd:pfam03154 320 QSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPalKPL 399

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910 385 DCFFARLPPSPVDDSLSLKtpPECLLVPLPPPVDDFLT---------PQAPPIKRRRLGPVAFPRADDLRRPKEPPDCFF 455
Cdd:pfam03154 400 SSLSTHHPPSAHPPPLQLM--PQSQQLPPPPAQPPVLTqsqslpppaASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITP 477

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2463422910 456 VPLPPSPVDDSLSPKTPPECLLVPLPPPVDDFLTPQAPPIKRRRLGPvaflraDDFRRPKEPP 518
Cdd:pfam03154 478 PSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEAL------DEAEEPESPP 534
 
Name Accession Description Interval E-value
NPIP pfam06409
Nuclear pore complex interacting protein (NPIP); This family consists of a series of primate ...
 23-248 1.30e-34

Nuclear pore complex interacting protein (NPIP); This family consists of a series of primate specific nuclear pore complex interacting protein (NPIP) sequences. The function of this family is unknown but is well conserved from African apes to humans.


Pssm-ID: 461900 [Multi-domain]  Cd Length: 267  Bit Score: 131.79  E-value: 1.30e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  23 VSFLKTVLKSQNVHDGSTDVQRKAWRSNSHSQEGIKIGLEDLFTSQRHMEAKVRAEVHK--VTRNVNSHYKINGHRKTAK 100
Cdd:pfam06409  65 QRALKSIFPRQEGHDGSLDDIFRARRQNERKQEAIICKLEDIFKLNRHDEIKGKAKIAKehLRKKSMKEDEHGEKEKQAK 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910 101 ---------------KKKLFQRMQELRRRAQDYYRCKITPSARKPLANslcaqalqrgkaERKAAYKQHRcqmrqkkrvp 165
Cdd:pfam06409 145 eaeekgkldekehgeKEEMFQEAEALGKLAEDEIHCKIEMFARAPACN------------RRAEAAAECK---------- 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910 166 erhmsqepvqgrlglenpfsmdsgpHSVPMRNsngvPAENTektkVRMVAVEHHHSSGLRYRPYLPAETLRKRIGRKPPP 245
Cdd:pfam06409 203 -------------------------HSPGAPK----PLCLR----AEMAAAEHGHQPGLPTQPHLIADNLKNLKGHPECL 249


                  ...
gi 2463422910 246 PIQ 248
Cdd:pfam06409 250 LTP 252
PHA03247 PHA03247
large tegument protein UL36; Provisional
 227-569 7.94e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 7.94e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  227 RPYLPAETLRKRIGRKPPPPIQCDLRGQPRPSVKGCLRPLTLSRLQCPLGPQPHS-----------TTDDFLRRETPQDE 295
Cdd:PHA03247  2576 RPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSpspaanepdphPPPTVPPPERPRDD 2655

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  296 CALGPDPLPR----ADDFPRLKTPPEGLFIPISPSPVDDSLSLKTPPEcllVPLPPSPVDDFLTPQAPPIKRRRLGPVAF 371
Cdd:PHA03247  2656 PAPGRVSRPRrarrLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPP---PPPTPEPAPHALVSATPLPPGPAAARQAS 2732

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  372 PRADDFRRPKEPPDCFFARLPPSPVDDSLSLKTPPEcllvPLPPPVDDFLTPQAPPIKRRRLGPVAFPRADDLRRPKEPP 451
Cdd:PHA03247  2733 PALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA----PAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPP 2808

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  452 DCFFVPLPPSPVDDSLSPKTPPECLLVPLPPPvddfLTPQAPPIKRRRLGPVAflRADDFRR-------------PKEPP 518
Cdd:PHA03247  2809 AAVLAPAAALPPAASPAGPLPPPTSAQPTAPP----PPPGPPPPSLPLGGSVA--PGGDVRRrppsrspaakpaaPARPP 2882

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2463422910  519 DCFFARLPPSPVDDSLSLKTPPECLLVPLPPPVDDFLTPQAPPIKRRRLGP 569
Cdd:PHA03247  2883 VRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPP 2933
PHA03247 PHA03247
large tegument protein UL36; Provisional
 338-573 3.05e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 3.05e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  338 PECLLVPLPPSPVDDFLTPQAPPIKRRrLGPVAFPRAddfRRPKEPPDcffARLPPSPVDDSLSLKTPPEcllvPLPPPV 417
Cdd:PHA03247  2551 PPPPLPPAAPPAAPDRSVPPPRPAPRP-SEPAVTSRA---RRPDAPPQ---SARPRAPVDDRGDPRGPAP----PSPLPP 2619

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  418 DDflTPQAPPIKRRRlgpvafPRADDLRRPKEPPdcffVPLPPSPVDDSLSPKTPPECLLVPLPPPVDDFLTPQAP--PI 495
Cdd:PHA03247  2620 DT--HAPDPPPPSPS------PAANEPDPHPPPT----VPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPrrRA 2687

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  496 KRRRLGPVA-FLRADDFRRPKEPPDCFFARLPPSPVDDSLSLKTPPECLLVPLPPPV-DDFLTPQAPPIKRRRLGPVAFP 573
Cdd:PHA03247  2688 ARPTVGSLTsLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVpAGPATPGGPARPARPPTTAGPP 2767
PHA03247 PHA03247
large tegument protein UL36; Provisional
 310-561 3.18e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 3.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  310 PRLKTPPEGLFiPISPSPVDDSLSLktPPECLLVPLPPSPVDDFLTPQAPPikrrrlGPVAFPRADDFRRPKEPPDCFFA 389
Cdd:PHA03247  2478 PVYRRPAEARF-PFAAGAAPDPGGG--GPPDPDAPPAPSRLAPAILPDEPV------GEPVHPRMLTWIRGLEELASDDA 2548

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  390 RLPPSPVDDSLSLKTPPECLLVPLPPPvddflTPQAPPIKRRRLGPVAFPRADDLRRPKEPPDCFFVPLPPSPVDDSLSP 469
Cdd:PHA03247  2549 GDPPPPLPPAAPPAAPDRSVPPPRPAP-----RPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHA 2623

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  470 KTPPECLLVPLPPPVDDFLTPQAPPIKRRRLGPvAFLRADDFRR---------PKEPPDCFFARLPPSPVDDSLSLKTPP 540
Cdd:PHA03247  2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDP-APGRVSRPRRarrlgraaqASSPPQRPRRRAARPTVGSLTSLADPP 2702

                          250       260
                   ....*....|....*....|.
gi 2463422910  541 ECLLVPLPPPVDDFLTPQAPP 561
Cdd:PHA03247  2703 PPPPTPEPAPHALVSATPLPP 2723
PHA03247 PHA03247
large tegument protein UL36; Provisional
 225-494 3.74e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 3.74e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  225 RYRPYLPAETLRKRIGRKP-PPPIQCDLRGQPRPSVKGCLRPLTLSRLQCPLGPQPHSTTDDFLRRETPQDECALGPDPL 303
Cdd:PHA03247  2653 RDDPAPGRVSRPRRARRLGrAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQAS 2732

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  304 PRADDFPRLKTPPEGLFIPISPSPVDDSLSLKTPPECLLVPLPPSPVDDFLTPqaPPIKRRRLGPVAFPRADDfrrPKEP 383
Cdd:PHA03247  2733 PALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR--PAVASLSESRESLPSPWD---PADP 2807

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  384 PDCFFARLPPSPVDDSLSLKTPPECLLVPLPP-----PVDDFLTPQ---APPIKRRRLGPV----------AFPRADDLR 445
Cdd:PHA03247  2808 PAAVLAPAAALPPAASPAGPLPPPTSAQPTAPppppgPPPPSLPLGgsvAPGGDVRRRPPSrspaakpaapARPPVRRLA 2887

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 2463422910  446 RPKEPPDCFFVPLPPSPVDDSLSPKTPPECLLVPLPPPVDDFLTPQAPP 494
Cdd:PHA03247  2888 RPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPP 2936
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 228-517 6.88e-05

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 45.69  E-value: 6.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910 228 PYLPAETLRKRIGRKPPPPIQCDLRGQPRPSvkgclrPLTlsrlqcPLGPQPHSTTDDflrrETPQDECALGPDPLPRAD 307
Cdd:PLN03209  312 PLTPMEELLAKIPSQRVPPKESDAADGPKPV------PTK------PVTPEAPSPPIE----EEPPQPKAVVPRPLSPYT 375

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910 308 DFPRLKTPPEGlfIPISPS------PVDDSLSLKTPPECLLVPLPPSPVDDFLTPQAPPIKRRRLGPVAfpRADDFRRPK 381
Cdd:PLN03209  376 AYEDLKPPTSP--IPTPPSsspassKSVDAVAKPAEPDVVPSPGSASNVPEVEPAQVEAKKTRPLSPYA--RYEDLKPPT 451

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910 382 EPPdcffarlPPSPVDDSLSLKTPPECLLVPLPPPVDDFLTPQAPPIKRRRlGPVAFPRADDLRRPKEPPDCFFVPLPPS 461
Cdd:PLN03209  452 SPS-------PTAPTGVSPSVSSTSSVPAVPDTAPATAATDAAAPPPANMR-PLSPYAVYDDLKPPTSPSPAAPVGKVAP 523

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2463422910 462 PVddslSPKTPPECLLVPLPPPVDDFLTPQAPPikrRRLGPvaFLRADDFRRPKEP 517
Cdd:PLN03209  524 SS----TNEVVKVGNSAPPTALADEQHHAQPKP---RPLSP--YTMYEDLKPPTSP 570
PHA03247 PHA03247
large tegument protein UL36; Provisional
 360-566 2.23e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 2.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  360 PIKRRRLGPVAFPRADDFRRPKEPPDCFFARLPPSPVDDSlslktPPECLLVPLPPPVDDFLTPQAPPikrrrlGPVAFP 439
Cdd:PHA03247  2463 PFSLSLLLGELFPGAPVYRRPAEARFPFAAGAAPDPGGGG-----PPDPDAPPAPSRLAPAILPDEPV------GEPVHP 2531

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  440 R------------ADDLRRPKEPpdcfFVPLPPSPVDDSLSPktPPECLLVPLPPPVDDFLT-PQAPPIKRRRLGPVAfl 506
Cdd:PHA03247  2532 RmltwirgleelaSDDAGDPPPP----LPPAAPPAAPDRSVP--PPRPAPRPSEPAVTSRARrPDAPPQSARPRAPVD-- 2603

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2463422910  507 RADDFRRPKE----PPDCffARLPPSPVDDSLSLKTPPECLLVPLPPPVDDFLTPQAPPIKRRR 566
Cdd:PHA03247  2604 DRGDPRGPAPpsplPPDT--HAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPR 2665
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 157-518 9.79e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 9.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910 157 QMRQKKRVPERHMSQEPVQGRLGLENPFSMDSG--PHSVPMRNSNGVPAENTEKTKVRMVAVEHH--HSSGLRYRPYLPA 232
Cdd:pfam03154 165 QILQTQPPVLQAQSGAASPPSPPPPGTTQAATAgpTPSAPSVPPQGSPATSQPPNQTQSTAAPHTliQQTPTLHPQRLPS 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910 233 ETLRKRIGRKPPPPIQCDLRGQPRPSVKGCLRPLTL------SRLQCPLGPQPHSTTDdflrrETPQDECALGPDPLPRA 306
Cdd:pfam03154 245 PHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHslqtgpSHMQHPVPPQPFPLTP-----QSSQSQVPPGPSPAAPG 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910 307 DDFPRLKTPPEGLFIPISPSPVDDSLSLKTPPECLLVPLPPSPVDDFLTPQAPPIKRRRLGPVAFPRADDFRRPK--EPP 384
Cdd:pfam03154 320 QSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPalKPL 399

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910 385 DCFFARLPPSPVDDSLSLKtpPECLLVPLPPPVDDFLT---------PQAPPIKRRRLGPVAFPRADDLRRPKEPPDCFF 455
Cdd:pfam03154 400 SSLSTHHPPSAHPPPLQLM--PQSQQLPPPPAQPPVLTqsqslpppaASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITP 477

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2463422910 456 VPLPPSPVDDSLSPKTPPECLLVPLPPPVDDFLTPQAPPIKRRRLGPvaflraDDFRRPKEPP 518
Cdd:pfam03154 478 PSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEAL------DEAEEPESPP 534
PHA03247 PHA03247
large tegument protein UL36; Provisional
 125-494 1.59e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 1.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  125 PSARKPLANSLCAQALQRGKAERKAAYKQHRCQMRQKKRVPERHMSQEPVQGRLGLENPFSMDSGPHSVPMRNSNGVPAE 204
Cdd:PHA03247  2643 PPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLP 2722

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  205 nTEKTKVRMVAVEHHHSSGLRYRPYLPAETLRKRIGRKPPPPIQCDLRGQPRPSVKGCLRPLTLsrlqcplgPQPHSTTD 284
Cdd:PHA03247  2723 -PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR--------PAVASLSE 2793

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  285 DFLRRETPQDECALGPDPLPRADDFPRLKTPPEGLFIPISPSPvddslslkTPPecllvPLPPSPVDDFLTPQ---APPI 361
Cdd:PHA03247  2794 SRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP--------TAP-----PPPPGPPPPSLPLGgsvAPGG 2860

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910  362 KRRRLGPVAFPRADDFRRPKePPDCFFARLPPSPVDDSLSLKTPPecllvPLPPPvddflTPQAPPIKRRRLGPVAFPRA 441
Cdd:PHA03247  2861 DVRRRPPSRSPAAKPAAPAR-PPVRRLARPAVSRSTESFALPPDQ-----PERPP-----QPQAPPPPQPQPQPPPPPQP 2929

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2463422910  442 DDLRRPKEPPDCFFVPLPPSPVDDSLSPKTPPECL--LVPLPPPVDDFLTPQAPP 494
Cdd:PHA03247  2930 QPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLgaLVPGRVAVPRFRVPQPAP 2984
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 277-465 4.57e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 39.95  E-value: 4.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910 277 PQPHSTTDDFLRRETPQDECALGPDPLPRADDFPrlkTPPEGlfipISPSPVDDSLSLKTPPECLLVPLPPspvDDFLTP 356
Cdd:PTZ00441  263 PILHEGCTTHMVEECEEEECPVEPEPLPVPAPVP---PTPED----DNPRPTDDEFAVPNFNEGLDVPDNP---QDPVPP 332

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2463422910 357 QAPPIKRRRLGPVAFPRADDfRRPKEPPDcffARLPPSPVDDSlSLKTPPECLLVPLPPPVDDFLTPQAPPIKRRRLGPV 436
Cdd:PTZ00441  333 PNEGKDGNPNEENLFPPGDD-EVPDESNV---PPNPPNVPGGS-NSEFSSDVENPPNPPNPDIPEQEPNIPEDSNKEVPE 407

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2463422910 437 AFPRADDLRR------PKEPPDCFF---VPLPPSPVDD 465
Cdd:PTZ00441  408 DVPMEPEDDRdnnfnePKKPENKGDgqnEPVIPKPLDN 445
NPIP pfam06409
Nuclear pore complex interacting protein (NPIP); This family consists of a series of primate ...
 526-561 9.42e-03

Nuclear pore complex interacting protein (NPIP); This family consists of a series of primate specific nuclear pore complex interacting protein (NPIP) sequences. The function of this family is unknown but is well conserved from African apes to humans.


Pssm-ID: 461900 [Multi-domain]  Cd Length: 267  Bit Score: 38.18  E-value: 9.42e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 2463422910 526 PPSPVDDSLSLKTPPECLLVPLPPPVDDFLTPQAPP 561
Cdd:pfam06409 232 PHLIADNLKNLKGHPECLLTPLHPIADNSADDKLKP 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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