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Conserved domains on  [gi|2462546780|ref|XP_054235218|]
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GPI mannosyltransferase 3 isoform X4 [Homo sapiens]

Protein Classification

glycosyltransferase family protein( domain architecture ID 229536)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMT_2 super family cl21590
Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are ...
 1-288 7.19e-80

Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are not captured by pfam02366.


The actual alignment was detected with superfamily member pfam03901:

Pssm-ID: 473917  Cd Length: 414  Bit Score: 251.51  E-value: 7.19e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546780   1 MKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSM----NSVKYSSLVALAFIIRPTAVI 76
Cdd:pfam03901 102 VCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVsnykYLKAVLLIAALAILGRPTSAL 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546780  77 LWTPLLFRHFCQEPRK-LDLILHHFLPVGFVTLSLSL----MIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYF 151
Cdd:pfam03901 182 LWLPLVLYLLLRLRGKrLKLFLFLAISLGLLVALLVLgaviLIDSYFYGRFVFTPLNFLKYNVLSNGSSFYGTHPWYFYF 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546780 152 SQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLV----YSMLSHKEFRFIYPVLPFCMVFCGYSLTHLK--TWKK 225
Cdd:pfam03901 262 SNGLPNILGPFLLAFILGPLVLLLRKVSRLSQLLAPILIwlfiYSLQPHKEERFLYPVYPLILLSAAIALTRLSrrSWKV 341

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462546780 226 PA----LSFLFLSNLFLALYTGLVHQRGTL----DVMSHIQKVC--YNNPNKSSASIFIMMPCHSTPYYSHVH 288
Cdd:pfam03901 342 RKklslLFLLLFFNVSLARLFGLVHQYGAPlavyDVMSFLNETPreNRNPAGPPVNVCIGMECYSTPSSFFLH 414
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 1-288 7.19e-80

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 251.51  E-value: 7.19e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546780   1 MKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSM----NSVKYSSLVALAFIIRPTAVI 76
Cdd:pfam03901 102 VCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVsnykYLKAVLLIAALAILGRPTSAL 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546780  77 LWTPLLFRHFCQEPRK-LDLILHHFLPVGFVTLSLSL----MIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYF 151
Cdd:pfam03901 182 LWLPLVLYLLLRLRGKrLKLFLFLAISLGLLVALLVLgaviLIDSYFYGRFVFTPLNFLKYNVLSNGSSFYGTHPWYFYF 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546780 152 SQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLV----YSMLSHKEFRFIYPVLPFCMVFCGYSLTHLK--TWKK 225
Cdd:pfam03901 262 SNGLPNILGPFLLAFILGPLVLLLRKVSRLSQLLAPILIwlfiYSLQPHKEERFLYPVYPLILLSAAIALTRLSrrSWKV 341

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462546780 226 PA----LSFLFLSNLFLALYTGLVHQRGTL----DVMSHIQKVC--YNNPNKSSASIFIMMPCHSTPYYSHVH 288
Cdd:pfam03901 342 RKklslLFLLLFFNVSLARLFGLVHQYGAPlavyDVMSFLNETPreNRNPAGPPVNVCIGMECYSTPSSFFLH 414
PLN02816 PLN02816
mannosyltransferase
 9-379 1.99e-77

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 248.80  E-value: 1.99e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546780   9 VARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKS----MNSVKYSSLVALAFIIRPTAVILWTPLLFR 84
Cdd:PLN02816  148 VATWSLFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSidypVNRKWGLVIAALACAIRPTSAVIWLYVGML 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546780  85 HFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLP 164
Cdd:PLN02816  228 ELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLVMLFTFTP 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546780 165 FFIHGCYlaPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLK----------TWKKP-------- 226
Cdd:PLN02816  308 FSIAGII--KSKNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAFAQMEvsgssssssvTKKKQvprqnhtk 385

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546780 227 -------ALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKssaSIFIMMPCHSTPYYSHVHCPLPMRFLQCP 299
Cdd:PLN02816  386 wspklrlSVYFLLATNIPMALYMSLFHQRGTEDAMNYLSDEAYKGRVK---SILFLMPCHSTPYYSTLHRNIPMQFLDCT 462

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546780 300 PdlTGKSHYLDEADVFYLNPLNWLHREFHDDASLPTHLITFSILEEEISAFLISSNYKRTAVFFHTHLPEGR-IGSHIYV 378
Cdd:PLN02816  463 P--SAEKGELDESDQFLVNPLGFASELARNWSEPPSHIVLFASEETKLRDFMIQHSFKEVRRFFHAHFKVDRdLQSSVVV 540


                  .
gi 2462546780 379 Y 379
Cdd:PLN02816  541 Y 541
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 1-288 7.19e-80

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 251.51  E-value: 7.19e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546780   1 MKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSM----NSVKYSSLVALAFIIRPTAVI 76
Cdd:pfam03901 102 VCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVsnykYLKAVLLIAALAILGRPTSAL 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546780  77 LWTPLLFRHFCQEPRK-LDLILHHFLPVGFVTLSLSL----MIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYF 151
Cdd:pfam03901 182 LWLPLVLYLLLRLRGKrLKLFLFLAISLGLLVALLVLgaviLIDSYFYGRFVFTPLNFLKYNVLSNGSSFYGTHPWYFYF 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546780 152 SQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLV----YSMLSHKEFRFIYPVLPFCMVFCGYSLTHLK--TWKK 225
Cdd:pfam03901 262 SNGLPNILGPFLLAFILGPLVLLLRKVSRLSQLLAPILIwlfiYSLQPHKEERFLYPVYPLILLSAAIALTRLSrrSWKV 341

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462546780 226 PA----LSFLFLSNLFLALYTGLVHQRGTL----DVMSHIQKVC--YNNPNKSSASIFIMMPCHSTPYYSHVH 288
Cdd:pfam03901 342 RKklslLFLLLFFNVSLARLFGLVHQYGAPlavyDVMSFLNETPreNRNPAGPPVNVCIGMECYSTPSSFFLH 414
PLN02816 PLN02816
mannosyltransferase
 9-379 1.99e-77

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 248.80  E-value: 1.99e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546780   9 VARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKS----MNSVKYSSLVALAFIIRPTAVILWTPLLFR 84
Cdd:PLN02816  148 VATWSLFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSidypVNRKWGLVIAALACAIRPTSAVIWLYVGML 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546780  85 HFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLP 164
Cdd:PLN02816  228 ELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLVMLFTFTP 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546780 165 FFIHGCYlaPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSLTHLK----------TWKKP-------- 226
Cdd:PLN02816  308 FSIAGII--KSKNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAFAQMEvsgssssssvTKKKQvprqnhtk 385

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546780 227 -------ALSFLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKssaSIFIMMPCHSTPYYSHVHCPLPMRFLQCP 299
Cdd:PLN02816  386 wspklrlSVYFLLATNIPMALYMSLFHQRGTEDAMNYLSDEAYKGRVK---SILFLMPCHSTPYYSTLHRNIPMQFLDCT 462

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462546780 300 PdlTGKSHYLDEADVFYLNPLNWLHREFHDDASLPTHLITFSILEEEISAFLISSNYKRTAVFFHTHLPEGR-IGSHIYV 378
Cdd:PLN02816  463 P--SAEKGELDESDQFLVNPLGFASELARNWSEPPSHIVLFASEETKLRDFMIQHSFKEVRRFFHAHFKVDRdLQSSVVV 540


                  .
gi 2462546780 379 Y 379
Cdd:PLN02816  541 Y 541
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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