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Conserved domains on  [gi|2462543505|ref|XP_054233628|]
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leucine-rich repeat-containing protein 57 isoform X2 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-229 2.52e-27

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.10  E-value: 2.52e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  38 SNLRTIDLSNNKIESLPPLlIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSG 117
Cdd:COG4886   113 TNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSN 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505 118 NQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGEL-QVIELNLNQNQISQISvKISCCPRLKILRLEENclELSMLPQS 196
Cdd:COG4886   192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNN--QLTDLPPL 268

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2462543505 197 iLSDSQICLLAVEGNLFEIKKLRELEGYDKILL 229
Cdd:COG4886   269 -ANLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-229 2.52e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.10  E-value: 2.52e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  38 SNLRTIDLSNNKIESLPPLlIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSG 117
Cdd:COG4886   113 TNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSN 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505 118 NQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGEL-QVIELNLNQNQISQISvKISCCPRLKILRLEENclELSMLPQS 196
Cdd:COG4886   192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNN--QLTDLPPL 268

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2462543505 197 iLSDSQICLLAVEGNLFEIKKLRELEGYDKILL 229
Cdd:COG4886   269 -ANLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
21-211 2.92e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 83.21  E-value: 2.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  21 LKDRGLTEFPADLQKltsNLRTIDLSNNKIESLPPLLIGKftlLKSLSLNNNKLTVLPDEICNlkKLETLSLNNNHLREL 100
Cdd:PRK15370  185 LKILGLTTIPACIPE---QITTLILDNNELKSLPENLQGN---IKTLYANSNQLTSIPATLPD--TIQEMELSINRITEL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505 101 PSTFGqlSALKTLSLSGNQLGALPPQLC-SLRHLDVMDlskNQIRSIPDSVGElQVIELNLNQNQISQISVKISccPRLK 179
Cdd:PRK15370  257 PERLP--SALQSLDLFHNKISCLPENLPeELRYLSVYD---NSIRTLPAHLPS-GITHLNVQSNSLTALPETLP--PGLK 328

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2462543505 180 ILRLEENCleLSMLPQSILSDSQIclLAVEGN 211
Cdd:PRK15370  329 TLEAGENA--LTSLPASLPPELQV--LDVSKN 356
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 21-188 6.77e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 6.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  21 LKDRGLTEFpaDLQKLTSNLRTIDLSNNKIESLPPLliGKFTLLKSLSLNNNKLTVLpDEICNLKKLETLSLNNNHLREL 100
Cdd:cd21340     9 LNDKNITKI--DNLSLCKNLKVLYLYDNKITKIENL--EFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505 101 pSTFGQLSALKTLSLSGNQLgALPPQLC-----------SLRHLDVmdlSKNQIRSIPDSVGELQVIELNLNQNQIS--- 166
Cdd:cd21340    84 -EGLENLTNLEELHIENQRL-PPGEKLTfdprslaalsnSLRVLNI---SGNNIDSLEPLAPLRNLEQLDASNNQISdle 158

                         170       180
                  ....*....|....*....|..
gi 2462543505 167 QISVKISCCPRLKILRLEENCL 188
Cdd:cd21340   159 ELLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
38-97 7.24e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 7.24e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462543505  38 SNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVL-PDEICNLKKLETLSLNNNHL 97
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-229 2.52e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 108.10  E-value: 2.52e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  38 SNLRTIDLSNNKIESLPPLlIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSALKTLSLSG 117
Cdd:COG4886   113 TNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSN 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505 118 NQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGEL-QVIELNLNQNQISQISvKISCCPRLKILRLEENclELSMLPQS 196
Cdd:COG4886   192 NQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLtNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNN--QLTDLPPL 268

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2462543505 197 iLSDSQICLLAVEGNLFEIKKLRELEGYDKILL 229
Cdd:COG4886   269 -ANLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
21-221 2.34e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 2.34e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  21 LKDRGLTEFPADLQKLTsNLRTIDLSNNKIESLPPLlIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLREL 100
Cdd:COG4886   143 LSNNQLTDLPEPLGNLT-NLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505 101 PSTFGQLSALKTLSLSGNQLGALPpQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIELNLNQNQISQISVKISCCPRLKI 180
Cdd:COG4886   221 PEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLN 299

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2462543505 181 LRLEENCLELSMLPQSILSDSQICLLAVEGNLFEIKKLREL 221
Cdd:COG4886   300 SLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-222 2.85e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 2.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  32 DLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNkltvlpDEICNLKKLETLSLNNNHLRELPSTFGQLSALK 111
Cdd:COG4886    66 LLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLK 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505 112 TLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGEL-QVIELNLNQNQISQISVKISCCPRLKILRLEENclEL 190
Cdd:COG4886   140 ELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLtNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN--QL 217

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2462543505 191 SMLPQSILSDSQICLLAVEGN----LFEIKKLRELE 222
Cdd:COG4886   218 TDLPEPLANLTNLETLDLSNNqltdLPELGNLTNLE 253
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
21-211 2.92e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 83.21  E-value: 2.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  21 LKDRGLTEFPADLQKltsNLRTIDLSNNKIESLPPLLIGKftlLKSLSLNNNKLTVLPDEICNlkKLETLSLNNNHLREL 100
Cdd:PRK15370  185 LKILGLTTIPACIPE---QITTLILDNNELKSLPENLQGN---IKTLYANSNQLTSIPATLPD--TIQEMELSINRITEL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505 101 PSTFGqlSALKTLSLSGNQLGALPPQLC-SLRHLDVMDlskNQIRSIPDSVGElQVIELNLNQNQISQISVKISccPRLK 179
Cdd:PRK15370  257 PERLP--SALQSLDLFHNKISCLPENLPeELRYLSVYD---NSIRTLPAHLPS-GITHLNVQSNSLTALPETLP--PGLK 328

                         170       180       190
                  ....*....|....*....|....*....|..
gi 2462543505 180 ILRLEENCleLSMLPQSILSDSQIclLAVEGN 211
Cdd:PRK15370  329 TLEAGENA--LTSLPASLPPELQV--LDVSKN 356
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-188 1.69e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.19  E-value: 1.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  38 SNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLT-VLPDEICNLKKLETLSLNNNHLR-ELPSTFGQLSALKTLSL 115
Cdd:PLN00113  140 PNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYL 219

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462543505 116 SGNQL-GALPPQ---LCSLRHLDVmdLSKNQIRSIPDSVGELQVIE-LNLNQNQIS-QISVKISCCPRLKILRLEENCL 188
Cdd:PLN00113  220 GYNNLsGEIPYEiggLTSLNHLDL--VYNNLTGPIPSSLGNLKNLQyLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSL 296
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
18-197 8.93e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 70.11  E-value: 8.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  18 VFQLKDRGLTEFPadlQKLTSNLRTIDLSNNKIESLPPLLIGKftlLKSLSLNNNKLTVLPDEICNlkKLETLSLNNNHL 97
Cdd:PRK15370  245 EMELSINRITELP---ERLPSALQSLDLFHNKISCLPENLPEE---LRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSL 316

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  98 RELPSTFGQlsALKTLSLSGNQLGALPPQLCSlrHLDVMDLSKNQIRSIPDSVGElQVIELNLNQNQISQISVKISCCpr 177
Cdd:PRK15370  317 TALPETLPP--GLKTLEAGENALTSLPASLPP--ELQVLDVSKNQITVLPETLPP-TITTLDVSRNALTNLPENLPAA-- 389

                         170       180
                  ....*....|....*....|
gi 2462543505 178 LKILRLEENclELSMLPQSI 197
Cdd:PRK15370  390 LQIMQASRN--NLVRLPESL 407
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 37-147 6.13e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.48  E-value: 6.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  37 TSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLT-VLPDEICNLKKLETLSLNNNHLR-ELPSTFGQLSALKTLS 114
Cdd:PLN00113  474 SKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLD 553

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2462543505 115 LSGNQL-GALPPQLCSLRHLDVMDLSKNQIR-SIP 147
Cdd:PLN00113  554 LSQNQLsGEIPKNLGNVESLVQVNISHNHLHgSLP 588
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 21-188 6.77e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 6.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  21 LKDRGLTEFpaDLQKLTSNLRTIDLSNNKIESLPPLliGKFTLLKSLSLNNNKLTVLpDEICNLKKLETLSLNNNHLREL 100
Cdd:cd21340     9 LNDKNITKI--DNLSLCKNLKVLYLYDNKITKIENL--EFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505 101 pSTFGQLSALKTLSLSGNQLgALPPQLC-----------SLRHLDVmdlSKNQIRSIPDSVGELQVIELNLNQNQIS--- 166
Cdd:cd21340    84 -EGLENLTNLEELHIENQRL-PPGEKLTfdprslaalsnSLRVLNI---SGNNIDSLEPLAPLRNLEQLDASNNQISdle 158

                         170       180
                  ....*....|....*....|..
gi 2462543505 167 QISVKISCCPRLKILRLEENCL 188
Cdd:cd21340   159 ELLDLLSSWPSLRELDLTGNPV 180
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
6-221 2.86e-10

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 59.79  E-value: 2.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505   6 LRAHVETaqktgvFQLKDRGLTEFPAdlqkLTSNLRTIDLSNNKIESLPPLLIGkftlLKSLSLNNNKLT---VLPDEIC 82
Cdd:PRK15387  220 LPAHITT------LVIPDNNLTSLPA----LPPELRTLEVSGNQLTSLPVLPPG----LLELSIFSNPLThlpALPSGLC 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  83 NL--------------KKLETLSLNNNHLRELPSTFGQL-----------------SALKTLSLSGNQLGALPP------ 125
Cdd:PRK15387  286 KLwifgnqltslpvlpPGLQELSVSDNQLASLPALPSELcklwaynnqltslptlpSGLQELSVSDNQLASLPTlpsely 365

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505 126 -------QLCSL----RHLDVMDLSKNQIRSIPDSVGELQviELNLNQNQISQISVKISCCPRLKILRleencLELSMLP 194
Cdd:PRK15387  366 klwaynnRLTSLpalpSGLKELIVSGNRLTSLPVLPSELK--ELMVSGNRLTSLPMLPSGLLSLSVYR-----NQLTRLP 438

                         250       260
                  ....*....|....*....|....*..
gi 2462543505 195 QSILSDSQICLLAVEGNLFEIKKLREL 221
Cdd:PRK15387  439 ESLIHLSSETTVNLEGNPLSERTLQAL 465
PLN03150 PLN03150
hypothetical protein; Provisional
 67-166 1.63e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 57.13  E-value: 1.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  67 LSLNNNKLT-VLPDEICNLKKLETLSLNNNHLR-ELPSTFGQLSALKTLSLSGNQLGAlppqlcslrhldvmdlsknqir 144
Cdd:PLN03150  423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNG---------------------- 480

                          90       100
                  ....*....|....*....|...
gi 2462543505 145 SIPDSVGELQVIE-LNLNQNQIS 166
Cdd:PLN03150  481 SIPESLGQLTSLRiLNLNGNSLS 503
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
4-131 4.74e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 55.86  E-value: 4.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505   4 SALRAHVetaqKTGVFQL--KDRGLTEFPAdlqKLTSNLRTIDLSNNKIESLPPLLIGKftlLKSLSLNNNKLTVLPDEI 81
Cdd:PRK15370  296 RTLPAHL----PSGITHLnvQSNSLTALPE---TLPPGLKTLEAGENALTSLPASLPPE---LQVLDVSKNQITVLPETL 365

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462543505  82 CnlKKLETLSLNNNHLRELPSTFGqlSALKTLSLSGNQLGALPPQLCSLR 131
Cdd:PRK15370  366 P--PTITTLDVSRNALTNLPENLP--AALQIMQASRNNLVRLPESLPHFR 411
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 18-188 1.68e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 1.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  18 VFQLKDRGLT-EFPADLQKlTSNLRTIDLSNNKIES-LPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNN 95
Cdd:PLN00113  336 VLQLWSNKFSgEIPKNLGK-HNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDN 414

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  96 HLR-ELPSTFGQL------------------------SALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIR-SIPDS 149
Cdd:PLN00113  415 SFSgELPSEFTKLplvyfldisnnnlqgrinsrkwdmPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRK 494

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2462543505 150 VGEL-QVIELNLNQNQIS-QISVKISCCPRLKILRLEENCL 188
Cdd:PLN00113  495 LGSLsELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQL 535
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 32-166 1.75e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 1.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  32 DLQKLTSnlrtIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLT-VLPDEICNLKKLETLSLNNNHLR-ELPSTFGQLSA 109
Cdd:PLN00113  282 SLQKLIS----LDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNN 357

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505 110 LKTLSLSGNQL-GALPPQLCSLRHLDVMDLSKNQIRS-IPDSVGELQVIE-LNLNQNQIS 166
Cdd:PLN00113  358 LTVLDLSTNNLtGEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRrVRLQDNSFS 417
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-166 2.47e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 2.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  26 LTEFPADLQKLTsNLRTIDLSNNKIESLPPLliGKFTLLKSLSLNNNKLTVLPDEiCNLKKLETLSLNNNHLRELPSTFG 105
Cdd:COG4886   217 LTDLPEPLANLT-NLETLDLSNNQLTDLPEL--GNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKEL 292

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462543505 106 QLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIELNLNQNQIS 166
Cdd:COG4886   293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLL 353
PLN03150 PLN03150
hypothetical protein; Provisional
 21-105 6.55e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.51  E-value: 6.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  21 LKDRGLTEF-PADLQKLtSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLT-VLPDEICNLKKLETLSLNNNHLR 98
Cdd:PLN03150  425 LDNQGLRGFiPNDISKL-RHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLS 503


                  ....*...
gi 2462543505  99 -ELPSTFG 105
Cdd:PLN03150  504 gRVPAALG 511
LRR_8 pfam13855
Leucine rich repeat;
38-97 7.24e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 7.24e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462543505  38 SNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVL-PDEICNLKKLETLSLNNNHL 97
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
31-197 1.22e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 1.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  31 ADLQKLTSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPSTFGQLSAL 110
Cdd:COG4886    19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505 111 KTLS-----------------LSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGEL-QVIELNLNQNQISQISVKI 172
Cdd:COG4886    99 TELDlsgneelsnltnlesldLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLtNLKSLDLSNNQLTDLPEEL 178

                         170       180
                  ....*....|....*....|....*
gi 2462543505 173 SCCPRLKILRLEENclELSMLPQSI 197
Cdd:COG4886   179 GNLTNLKELDLSNN--QITDLPEPL 201
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 37-188 4.84e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 4.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  37 TSNLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLT-VLPDEICNL-KKLETLSLNNNHLRElPSTFGQLSALKTLS 114
Cdd:PLN00113   68 SSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTsSSLRYLNLSNNNFTG-SIPRGSIPNLETLD 146

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462543505 115 LSGNQL-GALPPQLCSLRHLDVMDLSKNQIRS-IPDSVGELQVIE-LNLNQNQ-ISQISVKISCCPRLKILRLEENCL 188
Cdd:PLN00113  147 LSNNMLsGEIPNDIGSFSSLKVLDLGGNVLVGkIPNSLTNLTSLEfLTLASNQlVGQIPRELGQMKSLKWIYLGYNNL 224
LRR_8 pfam13855
Leucine rich repeat;
64-120 4.86e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 4.86e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462543505  64 LKSLSLNNNKLTVLPDEI-CNLKKLETLSLNNNHLREL-PSTFGQLSALKTLSLSGNQL 120
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 43-127 1.38e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 48.66  E-value: 1.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  43 IDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLT-VLPDEICNLKKLETLSLNNNHLR-ELPSTFGQLSALKTLSLSGNQL 120
Cdd:PLN03150  423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502


                  ....*...
gi 2462543505 121 -GALPPQL 127
Cdd:PLN03150  503 sGRVPAAL 510
LRR_8 pfam13855
Leucine rich repeat;
86-143 1.03e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 1.03e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  86 KLETLSLNNNHLREL-PSTFGQLSALKTLSLSGNQLGALPPQ-LCSLRHLDVMDLSKNQI 143
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 23-166 1.07e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.55  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  23 DRGLTEFPADLQKLTSnLRTIDLSNNKIESLPPLLIGKF----TLLKSLSLNNNKLTV-----LPDEICNLKKLETLSLN 93
Cdd:COG5238   222 DEGAEILAEALKGNKS-LTTLDLSNNQIGDEGVIALAEAlknnTTVETLYLSGNQIGAegaiaLAKALQGNTTLTSLDLS 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  94 NNHLRE-----LPSTFGQLSALKTLSLSGNQLG-----ALPPQLCSLRHLDVMDLSKNQIRSIPDS------VGELQVIE 157
Cdd:COG5238   301 VNRIGDegaiaLAEGLQGNKTLHTLNLAYNGIGaqgaiALAKALQENTTLHSLDLSDNQIGDEGAIalakylEGNTTLRE 380


                  ....*....
gi 2462543505 158 LNLNQNQIS 166
Cdd:COG5238   381 LNLGKNNIG 389
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 37-191 3.86e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 3.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  37 TSNLRTIDLSNNkieSLPPLLIGKF------TLLKSLSLNNNKL---------TVLPDEICNLKK--LETLSLNNNHLRE 99
Cdd:cd00116    80 GCGLQELDLSDN---ALGPDGCGVLesllrsSSLQELKLNNNGLgdrglrllaKGLKDLPPALEKlvLGRNRLEGASCEA 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505 100 LPSTFGQLSALKTLSLSGNQLG-----ALPPQLCSLRHLDVMDLSKNQIRSIPDS-VGEL-----QVIELNLNQNQISQI 168
Cdd:cd00116   157 LAKALRANRDLKELNLANNGIGdagirALAEGLKANCNLEVLDLNNNGLTDEGASaLAETlaslkSLEVLNLGDNNLTDA 236

                         170       180
                  ....*....|....*....|....*....
gi 2462543505 169 ------SVKISCCPRLKILRLEENCLELS 191
Cdd:cd00116   237 gaaalaSALLSPNISLLTLSLSCNDITDD 265
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 39-120 8.79e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.13  E-value: 8.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462543505  39 NLRTIDLSNNKIESLPPLLIGKFTLLKSLSLNNNKLT-VLPDEICNLKKLETLSLNNNHLR-ELPSTfGQLSALKTLSLS 116
Cdd:PLN00113  524 KLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgSLPST-GAFLAINASAVA 602


                  ....
gi 2462543505 117 GNQL 120
Cdd:PLN00113  603 GNID 606
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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