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Conserved domains on  [gi|2462541474|ref|XP_054232636|]
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tumor necrosis factor alpha-induced protein 2 isoform X1 [Homo sapiens]

Protein Classification

exocyst complex component Sec6 family protein( domain architecture ID 10532741)

exocyst complex component Sec6 family protein similar to human exocyst complex component 3, which is part of the exocyst complex that is involved in the docking of exocytic vesicles with fusion sites on the plasma membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sec6 pfam06046
Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 ...
 122-651 2.56e-141

Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.


:

Pssm-ID: 428738  Cd Length: 570  Bit Score: 425.99  E-value: 2.56e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 122 QSKVEALYELLRDQVLGVLRRPLEAPPERLR----QALAVVAEQEREDRQAAAAGPGTSG-----------LAATRPRRW 186
Cdd:pfam06046   1 FSKVDGLIEKFDKLLWEIIRNLLELVREGNTslvvRLARIVEREEKEDEKAEALREATKGhkdmatrfsinVFRRRPRGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 187 LQLWRRGVAEAAEERMGQRPAAGAEVPESV-FLHLGRTMKEDLEAVVERLKPLFPAEFGVVAAYAESYHQHFAAHLAAVA 265
Cdd:pfam06046  81 KDKFLEALEESVEERFEECREKFSEDDKKLeLLYNLDWVFDDLIVVKDLLAPLFPPHWKIFKTYANIYHNALHDLLQELV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 266 QF-ELCERDTYMLLLWVQNLYPNDIINSPKLvGELQGMgLGSLLPPRQIRLLEATFLSSEAANVRELMDRALELEARRWA 344
Cdd:pfam06046 161 DSeELEAADILAILSWVKTYYSKMMKGNPEL-EFDISD-LGPLLGDEVLEELEDDYLSLIVNKMREWLDNLLETEVKDFT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 345 EDVPP--QRLDGHCHSELAIDIIQITSQAQAKAesiTLDLGSQIKRVLLVELPAFLRSYQRAFNEFLERGKQLTN----- 417
Cdd:pfam06046 239 EREEPpeEDLDGYYHLPLPVDVFQMLAEQVDVA---ADSLQAKILVGVLEELAKFLRSRQDAWIELLEEELKKYMsvnnn 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 418 -----YRANVIANINNCLSFR---MSMEQNW------QVPQDTLSLLLGPLGELKSHGFDTLLQNLHEDLKPLFKRFTHT 483
Cdd:pfam06046 316 esppgLVEYLIALANDQLKCAdyaESLLQKYeplkyeERISDEFEELLDGLVDLSKECISALLDIIFNDLQPALSKLFTK 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 484 RWAAPvETLENIIATVDTRLPEFSE-LQGCFREELMEALHLHLVKEYIIQLSKGRLVlKTAEQQQQLAGYILANADTIQH 562
Cdd:pfam06046 396 KWYTG-EVMEQIVETVEDYLNDYKEyLHPPLFQELLEELLDELVVEYLRALRGKRLK-FGAEKQEQFAEKMKRDAEQLYD 473

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 563 FCTQHGSP-ATWLQPALPTLA---EIIRLQDPSAIKIEVATYATCYPDFSKGHLSAILAIKGNLSNSEVKRIRSILDVSM 638
Cdd:pfam06046 474 FFSKLGSRdAAWLLQALRAIEdllELLELEDPDAVPLEYETLLSSYPDISLDHVEAVLKARGDLDKSMVKALLQQLREIK 553

                         570
                  ....*....|....*..
gi 2462541474 639 GAQEPS----RPLFSLI 651
Cdd:pfam06046 554 KSYESGveppRTIFSRV 570
 
Name Accession Description Interval E-value
Sec6 pfam06046
Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 ...
 122-651 2.56e-141

Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.


Pssm-ID: 428738  Cd Length: 570  Bit Score: 425.99  E-value: 2.56e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 122 QSKVEALYELLRDQVLGVLRRPLEAPPERLR----QALAVVAEQEREDRQAAAAGPGTSG-----------LAATRPRRW 186
Cdd:pfam06046   1 FSKVDGLIEKFDKLLWEIIRNLLELVREGNTslvvRLARIVEREEKEDEKAEALREATKGhkdmatrfsinVFRRRPRGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 187 LQLWRRGVAEAAEERMGQRPAAGAEVPESV-FLHLGRTMKEDLEAVVERLKPLFPAEFGVVAAYAESYHQHFAAHLAAVA 265
Cdd:pfam06046  81 KDKFLEALEESVEERFEECREKFSEDDKKLeLLYNLDWVFDDLIVVKDLLAPLFPPHWKIFKTYANIYHNALHDLLQELV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 266 QF-ELCERDTYMLLLWVQNLYPNDIINSPKLvGELQGMgLGSLLPPRQIRLLEATFLSSEAANVRELMDRALELEARRWA 344
Cdd:pfam06046 161 DSeELEAADILAILSWVKTYYSKMMKGNPEL-EFDISD-LGPLLGDEVLEELEDDYLSLIVNKMREWLDNLLETEVKDFT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 345 EDVPP--QRLDGHCHSELAIDIIQITSQAQAKAesiTLDLGSQIKRVLLVELPAFLRSYQRAFNEFLERGKQLTN----- 417
Cdd:pfam06046 239 EREEPpeEDLDGYYHLPLPVDVFQMLAEQVDVA---ADSLQAKILVGVLEELAKFLRSRQDAWIELLEEELKKYMsvnnn 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 418 -----YRANVIANINNCLSFR---MSMEQNW------QVPQDTLSLLLGPLGELKSHGFDTLLQNLHEDLKPLFKRFTHT 483
Cdd:pfam06046 316 esppgLVEYLIALANDQLKCAdyaESLLQKYeplkyeERISDEFEELLDGLVDLSKECISALLDIIFNDLQPALSKLFTK 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 484 RWAAPvETLENIIATVDTRLPEFSE-LQGCFREELMEALHLHLVKEYIIQLSKGRLVlKTAEQQQQLAGYILANADTIQH 562
Cdd:pfam06046 396 KWYTG-EVMEQIVETVEDYLNDYKEyLHPPLFQELLEELLDELVVEYLRALRGKRLK-FGAEKQEQFAEKMKRDAEQLYD 473

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 563 FCTQHGSP-ATWLQPALPTLA---EIIRLQDPSAIKIEVATYATCYPDFSKGHLSAILAIKGNLSNSEVKRIRSILDVSM 638
Cdd:pfam06046 474 FFSKLGSRdAAWLLQALRAIEdllELLELEDPDAVPLEYETLLSSYPDISLDHVEAVLKARGDLDKSMVKALLQQLREIK 553

                         570
                  ....*....|....*..
gi 2462541474 639 GAQEPS----RPLFSLI 651
Cdd:pfam06046 554 KSYESGveppRTIFSRV 570
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
76-265 6.16e-03

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 39.61  E-value: 6.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474  76 PPTVEELKAALERGQLEAARPLLALERELAAAAAAGGVSEEELVRRQSKVEALYELLRDQVLGVLRRPLEAPPERLRQAL 155
Cdd:COG0515   255 YQSAAELAAALRAVLRSLAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAPAAAAAAAAAAA 334

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 156 AVVAEQEREDRQAAAAGPGTSgLAATRPRRWLQLWRRGVAEAAEERMGQRPAAGAEVPESVFLHLGRTMKEDLEAVVERL 235
Cdd:COG0515   335 ALAAAAAAAAAAAAAALLAAA-AALAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAAAAAAAAAALAAAAAAAAAAAAA 413

                         170       180       190
                  ....*....|....*....|....*....|
gi 2462541474 236 KPLFPAEFGVVAAYAESYHQHFAAHLAAVA 265
Cdd:COG0515   414 AAAAAALAAAAAAAAAAAAAAAAAAAAAAR 443
 
Name Accession Description Interval E-value
Sec6 pfam06046
Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 ...
 122-651 2.56e-141

Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.


Pssm-ID: 428738  Cd Length: 570  Bit Score: 425.99  E-value: 2.56e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 122 QSKVEALYELLRDQVLGVLRRPLEAPPERLR----QALAVVAEQEREDRQAAAAGPGTSG-----------LAATRPRRW 186
Cdd:pfam06046   1 FSKVDGLIEKFDKLLWEIIRNLLELVREGNTslvvRLARIVEREEKEDEKAEALREATKGhkdmatrfsinVFRRRPRGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 187 LQLWRRGVAEAAEERMGQRPAAGAEVPESV-FLHLGRTMKEDLEAVVERLKPLFPAEFGVVAAYAESYHQHFAAHLAAVA 265
Cdd:pfam06046  81 KDKFLEALEESVEERFEECREKFSEDDKKLeLLYNLDWVFDDLIVVKDLLAPLFPPHWKIFKTYANIYHNALHDLLQELV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 266 QF-ELCERDTYMLLLWVQNLYPNDIINSPKLvGELQGMgLGSLLPPRQIRLLEATFLSSEAANVRELMDRALELEARRWA 344
Cdd:pfam06046 161 DSeELEAADILAILSWVKTYYSKMMKGNPEL-EFDISD-LGPLLGDEVLEELEDDYLSLIVNKMREWLDNLLETEVKDFT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 345 EDVPP--QRLDGHCHSELAIDIIQITSQAQAKAesiTLDLGSQIKRVLLVELPAFLRSYQRAFNEFLERGKQLTN----- 417
Cdd:pfam06046 239 EREEPpeEDLDGYYHLPLPVDVFQMLAEQVDVA---ADSLQAKILVGVLEELAKFLRSRQDAWIELLEEELKKYMsvnnn 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 418 -----YRANVIANINNCLSFR---MSMEQNW------QVPQDTLSLLLGPLGELKSHGFDTLLQNLHEDLKPLFKRFTHT 483
Cdd:pfam06046 316 esppgLVEYLIALANDQLKCAdyaESLLQKYeplkyeERISDEFEELLDGLVDLSKECISALLDIIFNDLQPALSKLFTK 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 484 RWAAPvETLENIIATVDTRLPEFSE-LQGCFREELMEALHLHLVKEYIIQLSKGRLVlKTAEQQQQLAGYILANADTIQH 562
Cdd:pfam06046 396 KWYTG-EVMEQIVETVEDYLNDYKEyLHPPLFQELLEELLDELVVEYLRALRGKRLK-FGAEKQEQFAEKMKRDAEQLYD 473

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 563 FCTQHGSP-ATWLQPALPTLA---EIIRLQDPSAIKIEVATYATCYPDFSKGHLSAILAIKGNLSNSEVKRIRSILDVSM 638
Cdd:pfam06046 474 FFSKLGSRdAAWLLQALRAIEdllELLELEDPDAVPLEYETLLSSYPDISLDHVEAVLKARGDLDKSMVKALLQQLREIK 553

                         570
                  ....*....|....*..
gi 2462541474 639 GAQEPS----RPLFSLI 651
Cdd:pfam06046 554 KSYESGveppRTIFSRV 570
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
76-265 6.16e-03

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 39.61  E-value: 6.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474  76 PPTVEELKAALERGQLEAARPLLALERELAAAAAAGGVSEEELVRRQSKVEALYELLRDQVLGVLRRPLEAPPERLRQAL 155
Cdd:COG0515   255 YQSAAELAAALRAVLRSLAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAPAAAAAAAAAAA 334

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462541474 156 AVVAEQEREDRQAAAAGPGTSgLAATRPRRWLQLWRRGVAEAAEERMGQRPAAGAEVPESVFLHLGRTMKEDLEAVVERL 235
Cdd:COG0515   335 ALAAAAAAAAAAAAAALLAAA-AALAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAAAAAAAAAALAAAAAAAAAAAAA 413

                         170       180       190
                  ....*....|....*....|....*....|
gi 2462541474 236 KPLFPAEFGVVAAYAESYHQHFAAHLAAVA 265
Cdd:COG0515   414 AAAAAALAAAAAAAAAAAAAAAAAAAAAAR 443
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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