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Conserved domains on  [gi|2462538888|ref|XP_054231381|]
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sodium/potassium/calcium exchanger 4 isoform X2 [Homo sapiens]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 75-634 9.57e-117

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 374.72  E-value: 9.57e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888   75 SPELRAAPGGAQDAAAGHKTASASKRVLPDTWrnrklmapvngtqtaknctdPAIH---EFPTDLFSNKERQHGAVLLHI 151
Cdd:TIGR00927  402 APAVPTTPSPSLTTALFPEAPSPSPSALPPGQ--------------------PDLHpkaEYPPDLFSVEERRQGWVVLHI 461

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  152 LGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCI 231
Cdd:TIGR00927  462 FGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFV 541

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  232 IGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYN------VKMQAFFTVK 305
Cdd:TIGR00927  542 IGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNkqielwVKEQLSRRPV 621

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  306 QKSIANG------------------------------NPVNSELEAVKEKPQYGKNPVVMVDEIMSS------------- 342
Cdd:TIGR00927  622 AKVMALGdlskgdvaeaehtgertgeegerpteaegeNGEESGGEAEQEGETETKGENESEGEIPAErkgeqegegeiea 701

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  343 --------------SPPKFTFPE--------------------------AGLRIMIT-NKFGPRTRLRMASRIIINERQR 381
Cdd:TIGR00927  702 keadhkgeteaeevEHEGETEAEgtedegeietgeegeevedegegeaeGKHEVETEgDRKETEHEGETEAEGKEDEDEG 781

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  382 LINSANGVSSK----PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPV---------------------- 435
Cdd:TIGR00927  782 EIQAGEDGEMKgdegAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAenqgeakqdekgvdggggsdgg 861

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  436 -------------------------EADFLSPFSV--PEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITA 488
Cdd:TIGR00927  862 dseeeeeeeeeeeeeeeeeeeeeeeEEENEEPLSLewPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGS 941

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  489 TLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGL 568
Cdd:TIGR00927  942 IMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLL 1021

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462538888  569 QTMvVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIE 634
Cdd:TIGR00927 1022 FSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLE 1086
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 75-634 9.57e-117

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 374.72  E-value: 9.57e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888   75 SPELRAAPGGAQDAAAGHKTASASKRVLPDTWrnrklmapvngtqtaknctdPAIH---EFPTDLFSNKERQHGAVLLHI 151
Cdd:TIGR00927  402 APAVPTTPSPSLTTALFPEAPSPSPSALPPGQ--------------------PDLHpkaEYPPDLFSVEERRQGWVVLHI 461

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  152 LGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCI 231
Cdd:TIGR00927  462 FGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFV 541

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  232 IGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYN------VKMQAFFTVK 305
Cdd:TIGR00927  542 IGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNkqielwVKEQLSRRPV 621

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  306 QKSIANG------------------------------NPVNSELEAVKEKPQYGKNPVVMVDEIMSS------------- 342
Cdd:TIGR00927  622 AKVMALGdlskgdvaeaehtgertgeegerpteaegeNGEESGGEAEQEGETETKGENESEGEIPAErkgeqegegeiea 701

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  343 --------------SPPKFTFPE--------------------------AGLRIMIT-NKFGPRTRLRMASRIIINERQR 381
Cdd:TIGR00927  702 keadhkgeteaeevEHEGETEAEgtedegeietgeegeevedegegeaeGKHEVETEgDRKETEHEGETEAEGKEDEDEG 781

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  382 LINSANGVSSK----PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPV---------------------- 435
Cdd:TIGR00927  782 EIQAGEDGEMKgdegAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAenqgeakqdekgvdggggsdgg 861

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  436 -------------------------EADFLSPFSV--PEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITA 488
Cdd:TIGR00927  862 dseeeeeeeeeeeeeeeeeeeeeeeEEENEEPLSLewPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGS 941

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  489 TLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGL 568
Cdd:TIGR00927  942 IMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLL 1021

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462538888  569 QTMvVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIE 634
Cdd:TIGR00927 1022 FSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLE 1086
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
167-629 4.61e-37

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 139.88  E-value: 4.61e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 167 DFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVRLT 246
Cdd:COG0530     2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 247 WWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKmqafftvkqksiaNGNPVNSELEAVKEKP 326
Cdd:COG0530    80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRAR-------------KEPAWEEVEEELEEKP 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 327 QYgknpvvmvdeimsssppkftfpeaglrimitnkfgprtrlrmasriiinerqrlinsangvsskplqngrheniengn 406
Cdd:COG0530   147 KM------------------------------------------------------------------------------ 148

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 407 vpvenpedpqqnqeqqpppqppppepepveadflspfsvpeargdkvkwvfTWPLIFLLcvtipncskprwekffmvtFI 486
Cdd:COG0530   149 ---------------------------------------------------SLWKALLL-------------------LV 158

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 487 TATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPW 566
Cdd:COG0530   159 LGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGA 238

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462538888 567 GLQTMVVnygstvkiNSRGLVYSVVLLLGsVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCF 629
Cdd:COG0530   239 LITPIPV--------DPAVLSFDLPVMLA-ATLLLLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 150-292 7.64e-27

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 106.53  E-value: 7.64e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 150 HILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNIL 229
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462538888 230 CIIGVCGLFAGQVVRLTW----WAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIM 292
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQ 147
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 488-623 5.72e-11

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 64.28  E-value: 5.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 488 ATLWIAVFSYIM-------VWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILV 560
Cdd:PRK10734  175 AFLWLGIALIIMpmatrmvIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVI 254

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462538888 561 GLGVPWGLQTMVVNYGSTVKinsrglVYSVVLLLgSVALTVLGihlnkWRLDRKLG------------VYVLVLY 623
Cdd:PRK10734  255 VLGLPALISPGEINPLAFSR------DYWVMLLV-SVIFALLC-----WRRKRRIGrgagalllggfiVWLAMLY 317
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 75-634 9.57e-117

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 374.72  E-value: 9.57e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888   75 SPELRAAPGGAQDAAAGHKTASASKRVLPDTWrnrklmapvngtqtaknctdPAIH---EFPTDLFSNKERQHGAVLLHI 151
Cdd:TIGR00927  402 APAVPTTPSPSLTTALFPEAPSPSPSALPPGQ--------------------PDLHpkaEYPPDLFSVEERRQGWVVLHI 461

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  152 LGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCI 231
Cdd:TIGR00927  462 FGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFV 541

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  232 IGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYN------VKMQAFFTVK 305
Cdd:TIGR00927  542 IGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNkqielwVKEQLSRRPV 621

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  306 QKSIANG------------------------------NPVNSELEAVKEKPQYGKNPVVMVDEIMSS------------- 342
Cdd:TIGR00927  622 AKVMALGdlskgdvaeaehtgertgeegerpteaegeNGEESGGEAEQEGETETKGENESEGEIPAErkgeqegegeiea 701

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  343 --------------SPPKFTFPE--------------------------AGLRIMIT-NKFGPRTRLRMASRIIINERQR 381
Cdd:TIGR00927  702 keadhkgeteaeevEHEGETEAEgtedegeietgeegeevedegegeaeGKHEVETEgDRKETEHEGETEAEGKEDEDEG 781

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  382 LINSANGVSSK----PLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPV---------------------- 435
Cdd:TIGR00927  782 EIQAGEDGEMKgdegAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAenqgeakqdekgvdggggsdgg 861

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  436 -------------------------EADFLSPFSV--PEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITA 488
Cdd:TIGR00927  862 dseeeeeeeeeeeeeeeeeeeeeeeEEENEEPLSLewPETRQKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGS 941

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888  489 TLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGL 568
Cdd:TIGR00927  942 IMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLL 1021

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462538888  569 QTMvVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIE 634
Cdd:TIGR00927 1022 FSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLE 1086
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 149-626 9.74e-47

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 167.50  E-value: 9.74e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 149 LHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNI 228
Cdd:TIGR00367   1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 229 LCIIGVCGLFAgQVVRLTWWaVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILimkynvkmqafFTVKQKS 308
Cdd:TIGR00367  81 LLILGLSAIFS-PIIVDKDW-LRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLL-----------FLVKNER 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 309 IANGNPVNSEleavkekpqygknpvvmvdeimsssppkftfpeaglrimitnkfgprtrlrmasriiinerqrlinsang 388
Cdd:TIGR00367 148 WVKYDTYTEE---------------------------------------------------------------------- 157

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 389 vsskplQNGrheniengnvpvENPEDpqqnqeqqpppqppppepepveadflspfsvpeargdkvkwvftwPLIFllcvt 468
Cdd:TIGR00367 158 ------NLD------------ENNRR---------------------------------------------PQIF----- 169

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 469 ipncskprwekFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVS 548
Cdd:TIGR00367 170 -----------FSLVLLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVG 238

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462538888 549 NTIGSNVFDILVGLGVPWGLQTMVVnygSTVKINSRGLVYSVVLLLgsvaltVLGIHLNKWRLDRKLGVYVLVLYAIF 626
Cdd:TIGR00367 239 NVIGSNIFNILVGLGVPSLFMPIPV---EPLAYNLDAPVMVIVTLL------LMLFFKTSMKLGRWEGILLLALYIAY 307
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
167-629 4.61e-37

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 139.88  E-value: 4.61e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 167 DFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVRLT 246
Cdd:COG0530     2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 247 WWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKmqafftvkqksiaNGNPVNSELEAVKEKP 326
Cdd:COG0530    80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRAR-------------KEPAWEEVEEELEEKP 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 327 QYgknpvvmvdeimsssppkftfpeaglrimitnkfgprtrlrmasriiinerqrlinsangvsskplqngrheniengn 406
Cdd:COG0530   147 KM------------------------------------------------------------------------------ 148

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 407 vpvenpedpqqnqeqqpppqppppepepveadflspfsvpeargdkvkwvfTWPLIFLLcvtipncskprwekffmvtFI 486
Cdd:COG0530   149 ---------------------------------------------------SLWKALLL-------------------LV 158

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 487 TATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPW 566
Cdd:COG0530   159 LGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGA 238

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462538888 567 GLQTMVVnygstvkiNSRGLVYSVVLLLGsVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCF 629
Cdd:COG0530   239 LITPIPV--------DPAVLSFDLPVMLA-ATLLLLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 150-292 7.64e-27

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 106.53  E-value: 7.64e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 150 HILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNIL 229
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462538888 230 CIIGVCGLFAGQVVRLTW----WAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIM 292
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLlkldLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQ 147
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 480-632 1.61e-26

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 105.38  E-value: 1.61e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 480 FFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDIL 559
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462538888 560 VGLGVPWGLQTMVVnYGSTVKINSRGLVYSVVLLLGSVALTVLgihLNKWRLDRKLGVYVLVLYAIFLCFSIM 632
Cdd:pfam01699  81 LVLGLSALIGPVKV-DSLLLKLDLGVLLLVALLLLLLLLLLLL---PLFGRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
126-292 6.22e-22

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 96.36  E-value: 6.22e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 126 DPAIHEFPTDLFSNKERQHGAVLLHILGALymfyALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASV 205
Cdd:COG0530   132 EPAWEEVEEELEEKPKMSLWKALLLLVLGL----ALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSI 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 206 IGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAG-----QVVRLTWWAVcrdsvyyTISVIVLIVFIY-DEQIVWWEGL 279
Cdd:COG0530   208 VAARKGEDDLAVGNIIGSNIFNILLVLGIGALITPipvdpAVLSFDLPVM-------LAATLLLLGLLRtGGRIGRWEGL 280

                         170
                  ....*....|...
gi 2462538888 280 VLIILYVFYILIM 292
Cdd:COG0530   281 LLLALYLAYLALL 293
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
510-634 1.14e-13

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 72.09  E-value: 1.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 510 LGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVpwglqTMVVnygSTVKINSRGLVYS 589
Cdd:COG0530    15 LGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGL-----AALI---RPLAVDRRVLRRD 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462538888 590 VVLLLGSVALTVLGIHLNkwRLDRKLGVYVLVLYAIFLCFSIMIE 634
Cdd:COG0530    87 LPFLLLASLLLLALLLDG--TLSRIDGVILLLLYVLYLYYLIRRA 129
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 155-285 1.14e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 71.36  E-value: 1.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 155 LYMFYALAIVCDDFFV----------------PSLEKICERLHL-SEDVAGATFMAAGSSTPELFASVIGVF---ITHGD 214
Cdd:TIGR00845  83 VYMFLGVSIIADRFMAsievitsqekeitikkPNGETTVTTVRIwNETVSNLTLMALGSSAPEILLSVIEVCghnFEAGD 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 215 VGVGTIVGSAVFNILCIIGVCGLF--AGQVVRL----------TWwavcrdSVY-YTISVIVLIVFIYDEQIVwWEGLVL 281
Cdd:TIGR00845 163 LGPSTIVGSAAFNMFIIIAICVYVipDGETRKIkhlrvffvtaAW------SVFaYVWLYLILAVFSPGVVEV-WEGLLT 235


                  ....
gi 2462538888 282 IILY 285
Cdd:TIGR00845 236 FFFF 239
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 485-631 3.21e-12

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 67.73  E-value: 3.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 485 FITATLWIAVFSY-IMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLG 563
Cdd:TIGR00367   6 YLILGLILLIYGAdLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILG 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462538888 564 vpwglqtmVVNYGSTVKINSRGLVYSVVLLLGSVALtvLGIHLNKWRLDRKLGVYVLVLYAIFLCFSI 631
Cdd:TIGR00367  86 --------LSAIFSPIIVDKDWLRRDILFYLLVSIL--LLFFGLDGQISRIDGVVLLILYIVYLLFLV 143
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 483-601 7.02e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 68.67  E-value: 7.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 483 VTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLG-DMAVSNTIGSNVFDILVG 561
Cdd:TIGR00845 757 ACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTGSNAVNVFLG 836

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2462538888 562 LGVPWGLQTMV-VNYGSTVKINSRGLVYSVVLLLGSVALTV 601
Cdd:TIGR00845 837 IGVAWSIAAIYhAANGTQFKVSPGTLAFSVTLFTIFAFICI 877
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 488-623 5.72e-11

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 64.28  E-value: 5.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 488 ATLWIAVFSYIM-------VWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILV 560
Cdd:PRK10734  175 AFLWLGIALIIMpmatrmvIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVI 254

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462538888 561 GLGVPWGLQTMVVNYGSTVKinsrglVYSVVLLLgSVALTVLGihlnkWRLDRKLG------------VYVLVLY 623
Cdd:PRK10734  255 VLGLPALISPGEINPLAFSR------DYWVMLLV-SVIFALLC-----WRRKRRIGrgagalllggfiVWLAMLY 317
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 499-633 1.23e-10

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 63.13  E-value: 1.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 499 MVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNygST 578
Cdd:PRK10734   22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIRPFTVH--SD 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462538888 579 VKINSRGLVYSVVLLLGSValtvlgihLNKWRLDRKLGVYVLVLYAIFLCFSIMI 633
Cdd:PRK10734  100 VLRRELPLMLLVSVLAGSV--------LYDGQLSRSDGIFLLLLAVLWLLFIVKI 146
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 145-631 1.86e-10

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 64.01  E-value: 1.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 145 GAVLLHI-LGALymFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASvIGVFI--THGDVGVGTIV 221
Cdd:PLN03151  139 GYAVLGVwLVAL--FYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVgkDAGEVGLNSVL 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 222 GSAVFNILCIIGVCGL-FAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNV---- 296
Cdd:PLN03151  216 GGAVFVTCVVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANEilrk 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 297 -----KMQA---FFTVKQKSIANGN----PVNS---ELEAVKEKPQygknpvvmvdeiMSSSPPKFTFpeaglrimitnk 361
Cdd:PLN03151  296 harrlKLDVvtpLLPVQGSIFSPSVeedeSMYSpllESDTESDVPR------------LQTSLPQWMW------------ 351

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 362 fgprtrlrmASRIIINERQRLINSANGvSSKPLQNGRHENIENGNvPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLS 441
Cdd:PLN03151  352 ---------ASNVAIYSNHFAKGSVHD-EERPPWGWTDEGAEVES-SLFSCSKLFSLLEMPLTIPRRLTIPIVEEDRWSK 420

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 442 PFSVPEARGDKVKWVFTWP-----------LIFLLCVTI---------PNCSKPRWEKFFMVT-----FITATLWIAVFS 496
Cdd:PLN03151  421 TYAVASASLAPVLLAFLWSsqddvslqariAAYFIGVAIgstlgflayKYTEPDRPPRRFLIPwvlggFIMSIVWFYMIA 500

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 497 YIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGlGD---MAVSNTIGSNVFDILVGLGVPWGLQTMVV 573
Cdd:PLN03151  501 NELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCYAGPMFNTLVGLGMSMLLGAWSK 579

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462538888 574 NYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSI 631
Cdd:PLN03151  580 SPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRV 637
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 146-239 1.27e-05

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 47.72  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462538888 146 AVLLHILGALYMFYALAIVCDDFFVpslekICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAV 225
Cdd:PRK10734  175 AFLWLGIALIIMPMATRMVIDNATV-----LANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNI 249

                          90
                  ....*....|....
gi 2462538888 226 FNILCIIGVCGLFA 239
Cdd:PRK10734  250 FNIVIVLGLPALIS 263
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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