|
Name |
Accession |
Description |
Interval |
E-value |
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
61-791 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 1361.43 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 61 GIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDF 140
Cdd:cd00764 1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 141 REREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGT 220
Cdd:cd00764 81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 221 DMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRT 300
Cdd:cd00764 161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 301 RGSRLNIIIVAEGAIDKNGKPITSEDIKN-------------------------------GSRMGVEAVMALLEGTPDTP 349
Cdd:cd00764 241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDlvverlgldtrvttlghvqrggtpsafdrilASLMGVEAVMALLEATPDTP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 350 ACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRP-PVSKSGSHTVAVMNVGAP 428
Cdd:cd00764 321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPqPLPEKTNLNIAIVNVGAP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 429 AAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQ 508
Cdd:cd00764 401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 509 GLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIE 588
Cdd:cd00764 481 GLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVE 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 589 TMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGI 668
Cdd:cd00764 561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 669 FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVAELKDQTd 748
Cdd:cd00764 641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTT- 719
|
730 740 750 760
....*....|....*....|....*....|....*....|...
gi 2462532436 749 FEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHITRKR 791
Cdd:cd00764 720 FEHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
64-772 |
0e+00 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 1122.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 64 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDFRER 143
Cdd:TIGR02478 1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 144 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMT 223
Cdd:TIGR02478 81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 224 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGS 303
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 304 RLNIIIVAEGAIDKNGKPITSEDIKN-------------------------------GSRMGVEAVMALLEGTPDTPACV 352
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDvlverlgldtritvlghvqrggapsafdrilATRQGVEAVLAVLESTPETPSPV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 353 VSLSGNQAVRLPLMECVQVTKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLA---HVRPPVSKSGSH-TVAVMNVGAP 428
Cdd:TIGR02478 321 ISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSipdDDKKLVPSEASRlRIAIIHVGAP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 429 AAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQ 508
Cdd:TIGR02478 401 AGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKID 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 509 GLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIE 588
Cdd:TIGR02478 481 GLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFVVE 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 589 TMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGI 668
Cdd:TIGR02478 561 TMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGR 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 669 FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANtPDSGCVLGMRKRALVFQPVA-ELKDQT 747
Cdd:TIGR02478 641 FDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSAD-DTSAVVIGIRGSNVLFTPVKqLLANET 719
|
730 740
....*....|....*....|....*
gi 2462532436 748 DFEHRIPKEQWWLKLRPILKILAKY 772
Cdd:TIGR02478 720 DFEHRRPKNQWWLQLRPLVRILAGR 744
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
64-400 |
2.97e-160 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 468.70 E-value: 2.97e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 64 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFRER 143
Cdd:cd00363 1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEG--DIKELDWESVSDIINRGGTIIGSARCKEFRTE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 144 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDllsdlqkagkitdeeatKSSYLNIVGLVGSIDNDFCGTDMT 223
Cdd:cd00363 79 EGRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPS-----------------KYQGFNVIGLPGTIDNDIKGTDYT 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 224 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGS 303
Cdd:cd00363 142 IGFDTALKTIVEAIDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEEMVDVIKKRRERGK 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 304 RLNIIIVAEGAIDKNGKPITSEDIKN-------------------------------GSRMGVEAVMALLEGTPDTPACV 352
Cdd:cd00363 222 RHGIVIVAEGAIDFIPKPITEKLLAKlveerlgfdtratvlghvqrggtptafdrilASRLGAEAVELLLEGTGGTPVGI 301
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 2462532436 353 VSLSGNQAVRLPLMECVQVTKDVtkamdekkfdeALKLRGRSFMNNWE 400
Cdd:cd00363 302 QNLNENQVVRHPLTEAVNMTKRV-----------GVDLEGRPFKKFAK 338
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
66-338 |
1.18e-112 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 343.17 E-value: 1.18e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 66 IAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGdhIKEATWESVSMMLQLGGTVIGSARCKDFREREG 145
Cdd:pfam00365 2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGD--IDELTWRDVSGILNRGGTILGTSRSKPFKTEEG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 146 RLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSdllsdlqkagkitdeeatkssyLNIVGLVGSIDNDFCGTDMTIG 225
Cdd:pfam00365 80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIG 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 226 TDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSEtRTRGSRL 305
Cdd:pfam00365 138 FDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD---IEELCEKIKE-LRKGKRF 213
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 2462532436 306 NIIIVAEGAIDKN-------------------------GKPiTSEDIKNGSRMGVEAV 338
Cdd:pfam00365 214 SIIVVAEGASDGEflaklieegtgietrvtvlghvqrgGTP-SAFDRILATRLGVKAV 270
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
420-702 |
5.69e-105 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 323.52 E-value: 5.69e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 420 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFE--- 496
Cdd:pfam00365 2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKTEEgre 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 497 QISANITKFNIQGLVIIGGFEAYTGGLELMEGRKqfdelcIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQS 576
Cdd:pfam00365 82 KIAENLKKLGIDALVVIGGDGSLTGANKLSEERG------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 577 AAGTkRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLvQKMKTTVkrgLVLRNEKCNenyTTDF 656
Cdd:pfam00365 156 ASSH-NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKEL-RKGKRFS---IIVVAEGAS---DGEF 227
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2462532436 657 IFNLYsEEGKGIfDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMN 702
Cdd:pfam00365 228 LAKLI-EEGTGI-ETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
64-388 |
1.56e-97 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 305.85 E-value: 1.56e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 64 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFRER 143
Cdd:PRK03202 2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 144 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADtfrsewsdLLSDLQkagkitdeeatkssyLNIVGLVGSIDNDFCGTDMT 223
Cdd:PRK03202 80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAK--------RLTEHG---------------IPVIGLPGTIDNDIAGTDYT 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 224 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 303
Cdd:PRK03202 137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD---IEELCAKIKKGRERGK 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 304 RLNIIIVAEGAIDKN-------------------------GKPiTSEDIKNGSRMGVEAVMALLEGTPDTpacVVSLSGN 358
Cdd:PRK03202 214 KHAIIVVAEGVMPAEelakeieertgletrvtvlghiqrgGSP-TAFDRVLASRMGAHAVELLLEGKGGR---MVGIQNN 289
|
330 340 350
....*....|....*....|....*....|
gi 2462532436 359 QAVRLPLMECVQVTKdvtkamdeKKFDEAL 388
Cdd:PRK03202 290 KIVHVPIEEAVENMK--------HPFDKDL 311
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
64-380 |
4.68e-97 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 305.46 E-value: 4.68e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 64 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFRER 143
Cdd:COG0205 2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 144 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADtfrsewsdllsdlqkagKITDEEAtkssyLNIVGLVGSIDNDFCGTDMT 223
Cdd:COG0205 80 EGREKALENLKKLGIDALVVIGGDGSLDGAA-----------------KLAEEYG-----IPVVGIPKTIDNDLPGTDYT 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 224 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 303
Cdd:COG0205 138 IGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD---LDKLLEKLKERRKRGK 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 304 RLNIIIVAEGAIDKNGKPITSED-------------------IKN---------------------------GSRMGVEA 337
Cdd:COG0205 215 GYSIIVVAEGAGDEDGEAVLEADtdafghvrlggigeylakeIEErtgietrvtvlghlqrggspsafdrvlASRLGAAA 294
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 2462532436 338 VMALLEGTPDtpaCVVSLSGNQAVRLPLMECVQVTKDVTKAMD 380
Cdd:COG0205 295 VELLLEGKTG---VMVGIRRGEIVLVPLEEVANKEKPVDPDSP 334
|
|
| PFKA_ATP |
TIGR02482 |
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ... |
66-367 |
9.94e-81 |
|
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 213713 [Multi-domain] Cd Length: 301 Bit Score: 261.13 E-value: 9.94e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 66 IAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFREREG 145
Cdd:TIGR02482 2 IGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLING--KIEPLESKNVSGIIHRGGTILGTARCPEFKTEEV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 146 RLRAAYNLVKRGITNLCVIGGDGSLTGAdtfrsewsdllSDLQKAGKItdeeatkssylNIVGLVGSIDNDFCGTDMTIG 225
Cdd:TIGR02482 80 REKAVENLKKLGIEGLVVIGGDGSYTGA-----------QKLYEEGGI-----------PVIGLPGTIDNDIPGTDYTIG 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 226 TDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDweeHLCRRLSETRTRGSRL 305
Cdd:TIGR02482 138 FDTALNTIIDAVDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYDID---ELIQRLKEQHEAGKKH 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 306 NIIIVAEGAIDKNGKPI--------------------------TSEDIKNGSRMGVEAVMALLEGTPDTpacVVSLSGNQ 359
Cdd:TIGR02482 215 SIIIVAEGNIVGSAKEVakkieektgietrvtvlghtqrggspSAFDRVLASRLGAKAVELLLEGKGGV---MIGIQNNK 291
|
....*...
gi 2462532436 360 AVRLPLME 367
Cdd:TIGR02482 292 IVTHPIEE 299
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
64-379 |
1.44e-75 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 247.71 E-value: 1.44e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 64 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFRER 143
Cdd:cd00763 1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAG--DIVPLDRYSVSDIINRGGTFLGSARFPEFKDE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 144 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADtfrsewsdllsdlqkagKITDEEatkssyLNIVGLVGSIDNDFCGTDMT 223
Cdd:cd00763 79 EGQAKAIEQLKKHGIDALVVIGGDGSYMGAM-----------------RLTEHG------FPCVGLPGTIDNDIPGTDYT 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 224 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 303
Cdd:cd00763 136 IGFDTALNTVVEAIDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFD---REEVANRIKAGIERGK 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 304 RLNIIIVAEGA-------------------------IDKNGKPiTSEDIKNGSRMGVEAVMALLEGtpdTPACVVSLSGN 358
Cdd:cd00763 213 KHAIVVVAEGVydvdelakeieeatgfetratvlghIQRGGSP-TAFDRILASRMGAYAVELLLAG---KGGLAVGIQNE 288
|
330 340
....*....|....*....|.
gi 2462532436 359 QAVRLPLMECVQVTKDVTKAM 379
Cdd:cd00763 289 QLVHHDIIDAIENMKPFKKDW 309
|
|
| PFK_mixed |
TIGR02483 |
phosphofructokinase; Members of this family that are characterized, save one, are ... |
66-334 |
1.52e-56 |
|
phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 274155 [Multi-domain] Cd Length: 324 Bit Score: 196.75 E-value: 1.52e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 66 IAVLTSGGDAQGMNAAVRAVVRVGIFT-GARVFFVHEGYQGLVDGgDHIKEATWESVSMMLQLGGTVIGSARCKDFR-ER 143
Cdd:TIGR02483 2 IGVLTGGGDCPGLNAVIRGVVRRAIAEyGWEVIGIRDGWRGLLEG-DTVPLLDLEDVRGILPRGGTILGSSRTNPFKyEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 144 EGRLRAAYNLVKRGITNLCVIGGDGSLTGAdtfrsewsdllSDLQKAGkitdeeatkssyLNIVGLVGSIDNDFCGTDMT 223
Cdd:TIGR02483 81 DGDDKIVANLKELGLDALIAIGGDGTLGIA-----------RRLADKG------------LPVVGVPKTIDNDLEATDYT 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 224 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPddDWEEhLCRRLSETRTRGS 303
Cdd:TIGR02483 138 FGFDTAVEIATEALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEIPF--DIDS-VCEKVRERFARGK 214
|
250 260 270
....*....|....*....|....*....|....
gi 2462532436 304 RLNIIIVAEGAIDKNGKPITSE---DIKNGSRMG 334
Cdd:TIGR02483 215 RFAIVVVAEGAKPKGGEMVVQEgvkDAFGHVRLG 248
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
419-768 |
1.10e-52 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 186.82 E-value: 1.10e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 419 TVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKS---F 495
Cdd:COG0205 3 RIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKTeegR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 496 EQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKqfdelcIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQ 575
Cdd:COG0205 83 EKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG------IPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 576 SAAGTkRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLqanVEHLVQKMKTTVKRGLV-----LRNEKCNE 650
Cdd:COG0205 157 TAASH-ERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKL---LEKLKERRKRGKGYSIIvvaegAGDEDGEA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 651 NYTTD-FIFNLYSEEGKGI-----------FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNW-MSGKikesyrngri 717
Cdd:COG0205 233 VLEADtDAFGHVRLGGIGEylakeieertgIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELlLEGK---------- 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 2462532436 718 fantpdSGCVLGMRKRALVFQPVAELKDQtdfEHRIPKEQWWLKLRPILKI 768
Cdd:COG0205 303 ------TGVMVGIRRGEIVLVPLEEVANK---EKPVDPDSPLIQLARELGI 344
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
420-700 |
2.26e-52 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 185.58 E-value: 2.26e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 420 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQIS 499
Cdd:cd00363 3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSARCKEFRTEEGRA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 500 A---NITKFNIQGLVIIGGFEAYTGGLELmegRKQFDELCIPFVVI--PATVSNNVPGSDFSVGADTALNTICTTCDRIK 574
Cdd:cd00363 83 KaaeNLKKHGIDALVVIGGDGSYTGADLL---TEEWPSKYQGFNVIglPGTIDNDIKGTDYTIGFDTALKTIVEAIDRIR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 575 QSAAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDlqanVEHLVQKMKTTVKRG----LVLRNEKcne 650
Cdd:cd00363 160 DTAS-SHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEW----EEEMVDVIKKRRERGkrhgIVIVAEG--- 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 2462532436 651 nyTTDFIFNLYSEEG-------KGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKA 700
Cdd:cd00363 232 --AIDFIPKPITEKLlaklveeRLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEA 286
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
420-700 |
4.55e-51 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 181.43 E-value: 4.55e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 420 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFE--- 496
Cdd:PRK03202 4 IGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEEgra 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 497 QISANITKFNIQGLVIIGGFEAYTGGLELMEGRkqfdelcIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQS 576
Cdd:PRK03202 84 KAIENLKKLGIDALVVIGGDGSYMGAKRLTEHG-------IPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 577 AAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKttvKRGLVLRNEK-CNENYTTD 655
Cdd:PRK03202 157 AS-SHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEELCAKIKKGRERGK---KHAIIVVAEGvMPAEELAK 232
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2462532436 656 FIfnlyseEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKA 700
Cdd:PRK03202 233 EI------EERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHA 271
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
420-700 |
2.67e-49 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 176.45 E-value: 2.67e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 420 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRtLPKKSFEQIS 499
Cdd:cd00763 3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSAR-FPEFKDEEGQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 500 A----NITKFNIQGLVIIGGFEAYTGGLELMEgrkqfdeLCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQ 575
Cdd:cd00763 82 AkaieQLKKHGIDALVVIGGDGSYMGAMRLTE-------HGFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 576 SAAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKttvKRGLVLRNEKCnenYTTD 655
Cdd:cd00763 155 TSS-SHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGK---KHAIVVVAEGV---YDVD 227
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2462532436 656 FIFNLYSEEGKgiFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKA 700
Cdd:cd00763 228 ELAKEIEEATG--FETRATVLGHIQRGGSPTAFDRILASRMGAYA 270
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
60-334 |
2.02e-40 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 152.53 E-value: 2.02e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 60 LGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFT-GARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCK 138
Cdd:PRK14071 1 MGEKKRIGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARPPQYIELDLDQVDDLLRMGGTILGTTNKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 139 D----------FREREGRLRAAYNlvKRGITNLCVIGGDGSLTgadtfrsewsdLLSDLQKAGKItdeeatkssylNIVG 208
Cdd:PRK14071 81 DpfafpmpdgsLRDRSQEIIDGYH--SLGLDALIGIGGDGSLA-----------ILRRLAQQGGI-----------NLVG 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 209 LVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwE 288
Cdd:PRK14071 137 IPKTIDNDVGATEVSIGFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYT---L 213
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2462532436 289 EHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNGSRMG 334
Cdd:PRK14071 214 ENVCKKIRERQEEGKNFCLVVVSEAVRTEEGEQVTKTQALGEDRYG 259
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
63-329 |
1.08e-39 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 157.12 E-value: 1.08e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 63 GKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGdhIKEATWESVSMMLQLGGTVIGSAR---CKD 139
Cdd:TIGR02478 389 RLRIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD--VRELTWSDVEGWVGEGGSELGTNRslpGDD 466
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 140 FREregrlrAAYNLVKRGITNLCVIGGDGSLTGadtfrsewsdlLSDLQKAgkitdEEATKSSYLNIVGLVGSIDNDFCG 219
Cdd:TIGR02478 467 LGT------IAYYFQQHKIDGLIIIGGFEAFEA-----------LYQLDAA-----REKYPAFRIPMVVIPATISNNVPG 524
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 220 TDMTIGTDSALHRIMEIVDAITTTAQ-SHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPD-DDWEE---HLCRR 294
Cdd:TIGR02478 525 TEYSLGSDTALNEITEYCDNIKQSASaSKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISlKDLQEdieHLKET 604
|
250 260 270
....*....|....*....|....*....|....*
gi 2462532436 295 LSETRTRGsrlnIIIVAEGAIdkngKPITSEDIKN 329
Cdd:TIGR02478 605 FAEGRAGK----LILRNEKAS----KVYTTDFIAR 631
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
66-326 |
1.99e-22 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 101.27 E-value: 1.99e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 66 IAVLTSGGDAQGMNAAVRAVVRVGIFTGA--RVFFVHEGYQGLVDGgDHIKeATWESVSMMLQLGGTVIGSARCKDFRER 143
Cdd:PTZ00286 90 AGIVTCGGLCPGLNVVIRELVMNLINNYGvkTIYGAKYGYKGLYKE-DWIK-LDPKDVKTIHRLGGTILGSSRGGFDPKV 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 144 egrlrAAYNLVKRGITNLCVIGGDGSLTGADtfrsewsdllsdlqkagKITDEEATKSSYLNIVGLVGSIDNDFCGTDMT 223
Cdd:PTZ00286 168 -----MVDTLIRHGINILFTLGGDGTHRGAL-----------------AIYKELRRRKLNISVVGIPKTIDNDIPIIDES 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 224 IGTDSALHRIMEIVDAITTTAQSHQRTF-VLEVMGRHCGYLALVTSLSCG-ADWVFIPEcppdDDWEEHLCRRLSETRTR 301
Cdd:PTZ00286 226 FGFQTAVEEAQNAIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASAdVNVCLIPE----FDIPLEGVLEYIEQRLQ 301
|
250 260
....*....|....*....|....*..
gi 2462532436 302 GSRLNIIIVAEGAID--KNGKPITSED 326
Cdd:PTZ00286 302 KKGHCVIVVAEGAGQslKDADLDLGTD 328
|
|
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
67-314 |
3.14e-22 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 100.33 E-value: 3.14e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 67 AVLTSGGDAQGMNAAVRAVVRV-----GIftgARVFFVHEGYQGLVDGGDH-IKEATWESVSMMLQLGGTVIGSARckdf 140
Cdd:PRK06830 84 AIVTCGGLCPGLNDVIRAIVLElhhhyGV---RRILGIRYGYQGLIPRYGHdPVELTPEVVADIHEFGGTILGSSR---- 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 141 rereGRLRAAY---NLVKRGITNLCVIGGDGSLTGadtfrsewsdllsdlqkAGKITDEEATKSSYLNIVGLVGSIDNDF 217
Cdd:PRK06830 157 ----GPQDPEEivdTLERMNINILFVIGGDGTLRG-----------------ASAIAEEIERRGLKISVIGIPKTIDNDI 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 218 CGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVL-EVMGRHCGYLALVTSLSCG-ADWVFIPECPPDDDWE----EHL 291
Cdd:PRK06830 216 NFIQKSFGFETAVEKATEAIRCAHVEANGAPNGIGLvKLMGRHSGFIAAYAALASKdVNFVLIPEVPFDLEGPngllAAL 295
|
250 260
....*....|....*....|...
gi 2462532436 292 CRRLSEtrtRGSRlnIIIVAEGA 314
Cdd:PRK06830 296 EKRLAE---RGHA--VIVVAEGA 313
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
420-702 |
9.73e-18 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 85.51 E-value: 9.73e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 420 VAVMNVGAPAAGMNAAVRSTVRIGLIQ-GNRVLVVHDGFEGLAKG--QIEEAGWSYVGGWTGQGGSKLGTKR-------- 488
Cdd:PRK14071 7 IGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILGTTNkgdpfafp 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 489 ----TLPKKSfEQISANITKFNIQGLVIIGGfeayTGGLELMegRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALN 564
Cdd:PRK14071 87 mpdgSLRDRS-QEIIDGYHSLGLDALIGIGG----DGSLAIL--RRLAQQGGINLVGIPKTIDNDVGATEVSIGFDTAVN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 565 TICTTCDRIKQSAAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIrdlqanvEHLVQKMKTTVKRG---- 640
Cdd:PRK14071 160 IATEALDRLHFTAA-SHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTL-------ENVCKKIRERQEEGknfc 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462532436 641 LVLRNEKC----NENYTTDFIF--NLYSEEGKGIFD---------SRKNVLGHMQQGGSPTPFDRNFATKMGAKAMN 702
Cdd:PRK14071 232 LVVVSEAVrteeGEQVTKTQALgeDRYGGIGQYLAEqiaertgaeTRVTVLGHIQRGGIPSPRDRLLASAFGVAAVD 308
|
|
| PRK06555 |
PRK06555 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated |
64-314 |
1.81e-13 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
Pssm-ID: 180620 [Multi-domain] Cd Length: 403 Bit Score: 73.12 E-value: 1.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 64 KAIAVLTSGGDAQGMNAAVRAVVR--VGIFTGARVFFVHEGYQGLVdGGDHIK--EATWESVSMMLQLGGTVIGSARCK- 138
Cdd:PRK06555 4 KKVALLTAGGLAPCLSSAVGGLIEryTEIAPEVEIIAYRSGYQGLL-LGDSIEitPAVRANAGLLHRYGGSPIGNSRVKl 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 139 ----D------FREREGRLR-AAYNLVKRGITNLCVIGGDGSLTGAdtfrsewSDLLSDLQKAGkitdeeatkssY-LNI 206
Cdd:PRK06555 83 tnvaDcvkrglVKEGENPLKvAAERLAADGVDILHTIGGDDTNTTA-------ADLAAYLAENG-----------YdLTV 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 207 VGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVL-EVMGRHCGYLALVTS----------------- 268
Cdd:PRK06555 145 VGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWLTAATArayrewldrqeyvpgfg 224
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2462532436 269 LSCGA---DWVFIPECPPDDDWEehlCRRLSETRTRGSRLNiIIVAEGA 314
Cdd:PRK06555 225 LSAERwdiHAVYLPEMAFDLEAE---AERLKAVMDEVGNVN-IFLSEGA 269
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
67-314 |
7.52e-13 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 71.38 E-value: 7.52e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 67 AVLTSGGDAQGMNAAVRAVV-RVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARckdfrereG 145
Cdd:PLN02884 57 AIVTCGGLCPGLNDVIRQIVfTLEIYGVKNIVGIPFGYRGFFEKGLSEMPLSRKVVQNIHLSGGSLLGVSR--------G 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 146 RLRAAY---NLVKRGITNLCVIGGDGSLTGADTfrsewsdllsdlqkagkITDEEATKSSYLNIVGLVGSIDNDFCGTDM 222
Cdd:PLN02884 129 GAKTSDivdSIEARGINMLFVLGGNGTHAGANA-----------------IHNECRKRKMKVSVVGVPKTIDNDILLMDK 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 223 TIGTDSALHRIMEIVDAITTTAQSHQRTF-VLEVMGRHCGYLALVTSLSCG-ADWVFIPECPPDDDWEEHLCRRLSE-TR 299
Cdd:PLN02884 192 TFGFDTAVEEAQRAINSAYIEAHSAYHGIgLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTLDGPNGVLRHLEHlIE 271
|
250
....*....|....*
gi 2462532436 300 TRGSRlnIIIVAEGA 314
Cdd:PLN02884 272 TKGSA--VVCVAEGA 284
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
164-323 |
5.58e-11 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 65.27 E-value: 5.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 164 IGGDGSltgADTfrsewsdllsdlqkAGKITdEEATKSSY-LNIVGLVGSIDNDFCGTDMTIGTDSALHRI----MEI-- 236
Cdd:PRK14072 110 NGGNDS---MDT--------------ALKVS-QLAKKMGYpIRCIGIPKTIDNDLPGTDHCPGFGSAAKYIatsvLEAal 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 237 -VDAITTTaqshQRTFVLEVMGRHCGYLALVTSLSC-----GADWVFIPECPPDDDweehlcRRLSETRTRGSRLN--II 308
Cdd:PRK14072 172 dVAAMANT----SKVFILEVMGRHAGWLAAAAALAKqnpddAPHLIYLPERPFDEE------KFLADVRAIVKRYGycVV 241
|
170
....*....|....*
gi 2462532436 309 IVAEGAIDKNGKPIT 323
Cdd:PRK14072 242 VVSEGIRDADGKFIA 256
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
67-314 |
9.36e-11 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 65.15 E-value: 9.36e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 67 AVLTSGGDAQGMNAAVRAVVrVGIFTG---ARVFFVHEGYQGLVdgGDHIKEATWESVSMMLQLGGTVIGSARCKdfrer 143
Cdd:PLN02564 91 CIVTCGGLCPGLNTVIREIV-CGLSYMygvTRILGIDGGYRGFY--SRNTIPLTPKVVNDIHKRGGTILGTSRGG----- 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 144 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEwsdllsdLQKAG-KITdeeatkssylnIVGLVGSIDNDFCGTDM 222
Cdd:PLN02564 163 HDTSKIVDSIQDRGINQVYIIGGDGTQKGASVIYEE-------IRRRGlKVA-----------VAGIPKTIDNDIPVIDK 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 223 TIGTDSALHRIMEIVDAITTTAQS-HQRTFVLEVMGRHCGYLALVTSL-SCGADWVFIPECPPDDDWE----EHLCRRLS 296
Cdd:PLN02564 225 SFGFDTAVEEAQRAINAAHVEAESvENGIGLVKLMGRYSGFIAMYATLaSRDVDCCLIPESPFYLEGKgglfEFIEKRLK 304
|
250
....*....|....*...
gi 2462532436 297 EtrtrgSRLNIIIVAEGA 314
Cdd:PLN02564 305 E-----NGHMVIVVAEGA 317
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
419-598 |
5.57e-08 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 56.20 E-value: 5.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 419 TVAVMNVGAPAAGMNAAVRSTVRIGLI--QGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTlpKKSFE 496
Cdd:PTZ00286 89 KAGIVTCGGLCPGLNVVIRELVMNLINnyGVKTIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTILGSSRG--GFDPK 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 497 QISANITKFNIQGLVIIGGFEAYTGGLELM-EGRKQfdELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQ 575
Cdd:PTZ00286 167 VMVDTLIRHGINILFTLGGDGTHRGALAIYkELRRR--KLNISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAYV 244
|
170 180
....*....|....*....|...
gi 2462532436 576 SAAGTKRRVFIIETMGGYCGYLA 598
Cdd:PTZ00286 245 EAKSAKNGVGIVKLMGRDSGFIA 267
|
|
| PTZ00287 |
PTZ00287 |
6-phosphofructokinase; Provisional |
51-316 |
6.69e-06 |
|
6-phosphofructokinase; Provisional
Pssm-ID: 240345 [Multi-domain] Cd Length: 1419 Bit Score: 50.04 E-value: 6.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 51 HEEHHAAKTLGIGkaiaVLTSGGDAQGMNAAVRavvrvGIFTGARVFFVHEGYQGLVDGGDHIKEATWESV--SMM---L 125
Cdd:PTZ00287 169 HESFKGGNVLKIG----IILSGGPAPGGHNVIS-----GIYDYAKRYNEQSQVIGFLGGIDGLYSKNYVTItdSLMnrfR 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 126 QLGG-TVIGSARCKdFREREGrLRAAYNLV-KRGITNLCVIGGDGSLTgadtfrsewsdllsdlqKAGKITDEEATKSSY 203
Cdd:PTZ00287 240 NLGGfNMLWSGRGK-VRNKDD-LIAIENIVaKLKLNGLVIIGGDGSNS-----------------NAALISEYFAERQIP 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 204 LNIVGLVGSIDNDFC--GTDMTIGTDSALHRIMEIVDAITTTAQS-HQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPE 280
Cdd:PTZ00287 301 ISIIGIPKTIDGDLKseAIEISFGFDTATKTYSEVIGNLCTDVKTgHNVYHVVRVMGRSASHVVLECALQTRPNIVLIGE 380
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 2462532436 281 CPPDD-----DWEEHLCRRLSETRTRGSRLNIIIVAEGAID 316
Cdd:PTZ00287 381 EVEKEnlslkDIVSNIVNTILKRRSLNKNYGVILIPEGLIE 421
|
|
| PTZ00468 |
PTZ00468 |
phosphofructokinase family protein; Provisional |
64-316 |
8.97e-04 |
|
phosphofructokinase family protein; Provisional
Pssm-ID: 185647 [Multi-domain] Cd Length: 1328 Bit Score: 43.04 E-value: 8.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 64 KAIAVLTSGGDAQGMNAAVRAVVR-VGIFTGARVFFvheGYQGLVDG--GDHIKEATWESVSMMLQLGG-TVIGSARCKd 139
Cdd:PTZ00468 103 RRIGVVLSGGQASGGHNVIAGLMSyIKLCNQSSQLF---GFLGGPEGvySERYRELTEDDINGILNQGGfNIICSGRHK- 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 140 fREREGRLRAAYNLV-KRGITNLCVIGGDGSLTGADtfrsewsdLLSDLQKagkitdeeaTKSSYLNIVGLVGSIDNDFC 218
Cdd:PTZ00468 179 -IETEEQMRASLEICeKLKLHGLVVIGGDDSNTNAA--------VLAEYFK---------RNSSSTVVVGCPKTIDGDLK 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462532436 219 G--TDMTIGTDSAL----HRIMEIVDAITTtaqSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPD-------- 284
Cdd:PTZ00468 241 NevIETSFGYDTAVktysEQIGSIMDAIKT---EGYGYYFVRLMGRSASHITLECGLQTRANMILIGEEIKEenrslmsi 317
|
250 260 270
....*....|....*....|....*....|...
gi 2462532436 285 -DDWEEHLCRRLSetrtRGSRLNIIIVAEGAID 316
Cdd:PTZ00468 318 vDEIVEMILKRDS----LGKKHGIVLLPEGLIE 346
|
|
| |
