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Conserved domains on  [gi|2462527531|ref|XP_054225900|]
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transmembrane protein 223 isoform X1 [Homo sapiens]

Protein Classification

TMEM70/TMEM186/TMEM223 family protein( domain architecture ID 9700)

TMEM70/TMEM186/TMEM223 family protein, such as human transmembrane protein 186 (TMEM186) which is part of the mitochondrial complex I assembly (MCIA) complex that is required for efficient assembly of the mitochondrial complex I

Gene Ontology:  GO:0031966|GO:0065003
PubMed:  32275929|32320651

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM70 super family cl06160
TMEM70/TMEM186/TMEM223 protein family; This entry represents the TMEM70/TMEM186/TMEM223 ...
 32-109 1.22e-13

TMEM70/TMEM186/TMEM223 protein family; This entry represents the TMEM70/TMEM186/TMEM223 protein family. TMEM70 is a family of proteins essential for assembly of the mitochondrial proton-transporting ATP synthase complex within the inner mitochondrial membrane. TMEM70 functions in the assembly of complexes I and V.


The actual alignment was detected with superfamily member pfam06979:

Pssm-ID: 462058  Cd Length: 151  Bit Score: 63.39  E-value: 1.22e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462527531  32 RDVLLFEHDRGRFFTILGLFCAGQGVFWASMAVAAVSRppvpvqpldaevpnrgPFDLRSALWRYGLAVGCGAIGYST 109
Cdd:pfam06979   1 KDVLLYTGDLTRFFRGLKIFSLSQSIFWLYLAPFAYTK----------------LINLGSNKLRVGLTGICGFFGFVT 62
 
Name Accession Description Interval E-value
TMEM70 pfam06979
TMEM70/TMEM186/TMEM223 protein family; This entry represents the TMEM70/TMEM186/TMEM223 ...
 32-109 1.22e-13

TMEM70/TMEM186/TMEM223 protein family; This entry represents the TMEM70/TMEM186/TMEM223 protein family. TMEM70 is a family of proteins essential for assembly of the mitochondrial proton-transporting ATP synthase complex within the inner mitochondrial membrane. TMEM70 functions in the assembly of complexes I and V.


Pssm-ID: 462058  Cd Length: 151  Bit Score: 63.39  E-value: 1.22e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462527531  32 RDVLLFEHDRGRFFTILGLFCAGQGVFWASMAVAAVSRppvpvqpldaevpnrgPFDLRSALWRYGLAVGCGAIGYST 109
Cdd:pfam06979   1 KDVLLYTGDLTRFFRGLKIFSLSQSIFWLYLAPFAYTK----------------LINLGSNKLRVGLTGICGFFGFVT 62
PRK05122 PRK05122
major facilitator superfamily transporter; Provisional
 48-110 1.52e-03

major facilitator superfamily transporter; Provisional


Pssm-ID: 235348 [Multi-domain]  Cd Length: 399  Bit Score: 37.17  E-value: 1.52e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462527531  48 LGLFCAGQGVFWASMAVAAV----------SRPPVPVQPldaevPNRGPFdlRSAL---WRYGLAVGCGAIGYSTI 110
Cdd:PRK05122  167 LGVLLYHWGGLAGLGLLIMLlallglllarPRPAVPPVK-----GERLPF--RRVLgrvWPYGMGLALASIGFGTI 235
 
Name Accession Description Interval E-value
TMEM70 pfam06979
TMEM70/TMEM186/TMEM223 protein family; This entry represents the TMEM70/TMEM186/TMEM223 ...
 32-109 1.22e-13

TMEM70/TMEM186/TMEM223 protein family; This entry represents the TMEM70/TMEM186/TMEM223 protein family. TMEM70 is a family of proteins essential for assembly of the mitochondrial proton-transporting ATP synthase complex within the inner mitochondrial membrane. TMEM70 functions in the assembly of complexes I and V.


Pssm-ID: 462058  Cd Length: 151  Bit Score: 63.39  E-value: 1.22e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462527531  32 RDVLLFEHDRGRFFTILGLFCAGQGVFWASMAVAAVSRppvpvqpldaevpnrgPFDLRSALWRYGLAVGCGAIGYST 109
Cdd:pfam06979   1 KDVLLYTGDLTRFFRGLKIFSLSQSIFWLYLAPFAYTK----------------LINLGSNKLRVGLTGICGFFGFVT 62
PRK05122 PRK05122
major facilitator superfamily transporter; Provisional
 48-110 1.52e-03

major facilitator superfamily transporter; Provisional


Pssm-ID: 235348 [Multi-domain]  Cd Length: 399  Bit Score: 37.17  E-value: 1.52e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462527531  48 LGLFCAGQGVFWASMAVAAV----------SRPPVPVQPldaevPNRGPFdlRSAL---WRYGLAVGCGAIGYSTI 110
Cdd:PRK05122  167 LGVLLYHWGGLAGLGLLIMLlallglllarPRPAVPPVK-----GERLPF--RRVLgrvWPYGMGLALASIGFGTI 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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