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Conserved domains on  [gi|2462527152|ref|XP_054225713|]
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transcription factor PU.1 isoform X1 [Homo sapiens]

Protein Classification

ETS domain-containing protein( domain architecture ID 10445940)

ETS (erythroblast transformation specific) domain-containing protein may function as a transcriptional regulator

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ets pfam00178
Ets-domain;
84-165 3.45e-37

Ets-domain;


:

Pssm-ID: 459700  Cd Length: 80  Bit Score: 123.38  E-value: 3.45e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527152  84 RLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSskHKEALAHRWGIQKGNRkKMTYQKMARALRNYGKTGEVKKVK-KKLT 162
Cdd:pfam00178   1 QLWQFLLDLLTDPEYSDIIKWTDKEEGEFRLV--DPEAVARLWGKRKGNP-KMTYEKLSRALRYYYKKGILEKVPgKRLT 77

                  ...
gi 2462527152 163 YQF 165
Cdd:pfam00178  78 YRF 80
 
Name Accession Description Interval E-value
Ets pfam00178
Ets-domain;
84-165 3.45e-37

Ets-domain;


Pssm-ID: 459700  Cd Length: 80  Bit Score: 123.38  E-value: 3.45e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527152  84 RLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSskHKEALAHRWGIQKGNRkKMTYQKMARALRNYGKTGEVKKVK-KKLT 162
Cdd:pfam00178   1 QLWQFLLDLLTDPEYSDIIKWTDKEEGEFRLV--DPEAVARLWGKRKGNP-KMTYEKLSRALRYYYKKGILEKVPgKRLT 77

                  ...
gi 2462527152 163 YQF 165
Cdd:pfam00178  78 YRF 80
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
82-170 1.28e-35

erythroblast transformation specific domain; variation of the helix-turn-helix motif


Pssm-ID: 197710  Cd Length: 87  Bit Score: 119.68  E-value: 1.28e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527152   82 KIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKeaLAHRWGIQKgNRKKMTYQKMARALRNYGKTGEVKKV-KKK 160
Cdd:smart00413   1 GIQLWQFLLDLLLDPENSDIIKWTDRDEGEFKLVDPEE--VARLWGQRK-NKPNMNYEKLSRALRYYYKKNILEKVpGKR 77
                           90
                   ....*....|
gi 2462527152  161 LTYQFSGEVL 170
Cdd:smart00413  78 LVYKFVKNPL 87
 
Name Accession Description Interval E-value
Ets pfam00178
Ets-domain;
84-165 3.45e-37

Ets-domain;


Pssm-ID: 459700  Cd Length: 80  Bit Score: 123.38  E-value: 3.45e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527152  84 RLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSskHKEALAHRWGIQKGNRkKMTYQKMARALRNYGKTGEVKKVK-KKLT 162
Cdd:pfam00178   1 QLWQFLLDLLTDPEYSDIIKWTDKEEGEFRLV--DPEAVARLWGKRKGNP-KMTYEKLSRALRYYYKKGILEKVPgKRLT 77

                  ...
gi 2462527152 163 YQF 165
Cdd:pfam00178  78 YRF 80
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
82-170 1.28e-35

erythroblast transformation specific domain; variation of the helix-turn-helix motif


Pssm-ID: 197710  Cd Length: 87  Bit Score: 119.68  E-value: 1.28e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462527152   82 KIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKeaLAHRWGIQKgNRKKMTYQKMARALRNYGKTGEVKKV-KKK 160
Cdd:smart00413   1 GIQLWQFLLDLLLDPENSDIIKWTDRDEGEFKLVDPEE--VARLWGQRK-NKPNMNYEKLSRALRYYYKKNILEKVpGKR 77
                           90
                   ....*....|
gi 2462527152  161 LTYQFSGEVL 170
Cdd:smart00413  78 LVYKFVKNPL 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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