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Conserved domains on  [gi|2462524715|ref|XP_054224515|]
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putative nuclease HARBI1 isoform X1 [Homo sapiens]

Protein Classification

transposase family protein( domain architecture ID 10595532)

transposase family protein might bind to the end of a transposon and catalyze the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Gene Ontology:  GO:0046872|GO:0004518

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DDE_Tnp_4 pfam13359
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
 148-328 5.99e-37

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.


:

Pssm-ID: 463855 [Multi-domain]  Cd Length: 158  Bit Score: 131.24  E-value: 5.99e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524715 148 VDCIHVAIKAP---NAEDLSYVNRKGLHSLNCLMVCDIRGTLMTVETNWPGSLQDCAVLQQSSLSSQFEAGMHKDSWLLd 224
Cdd:pfam13359   1 VDGTEIPIQRPsnlEARGQTYSNYKHHNTLKVLIVVTPNGKIIFVSKGYPGSVSDKSILENSGLLKALNLAFGPGDYIL- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524715 225 lpefhwkdwltvmsrtriystfssvnqGDSSFFLRTWLMTPLHIPE----TPAEYRYNMAHSATHSVIEKTFRTLCSRFR 300
Cdd:pfam13359  80 ---------------------------ADKGFPISDWLLVPYKKPGgaqlSPEEVEFNRRIASARIHVERVIGRLKGRFR 132

                         170       180
                  ....*....|....*....|....*....
gi 2462524715 301 CLdgsKGALQYS-PEKSSHIILACCVLHN 328
Cdd:pfam13359 133 IL---RGRLPISlPERLDKIVTVCCVLHN 158
 
Name Accession Description Interval E-value
DDE_Tnp_4 pfam13359
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
 148-328 5.99e-37

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.


Pssm-ID: 463855 [Multi-domain]  Cd Length: 158  Bit Score: 131.24  E-value: 5.99e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524715 148 VDCIHVAIKAP---NAEDLSYVNRKGLHSLNCLMVCDIRGTLMTVETNWPGSLQDCAVLQQSSLSSQFEAGMHKDSWLLd 224
Cdd:pfam13359   1 VDGTEIPIQRPsnlEARGQTYSNYKHHNTLKVLIVVTPNGKIIFVSKGYPGSVSDKSILENSGLLKALNLAFGPGDYIL- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524715 225 lpefhwkdwltvmsrtriystfssvnqGDSSFFLRTWLMTPLHIPE----TPAEYRYNMAHSATHSVIEKTFRTLCSRFR 300
Cdd:pfam13359  80 ---------------------------ADKGFPISDWLLVPYKKPGgaqlSPEEVEFNRRIASARIHVERVIGRLKGRFR 132

                         170       180
                  ....*....|....*....|....*....
gi 2462524715 301 CLdgsKGALQYS-PEKSSHIILACCVLHN 328
Cdd:pfam13359 133 IL---RGRLPISlPERLDKIVTVCCVLHN 158
 
Name Accession Description Interval E-value
DDE_Tnp_4 pfam13359
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ...
 148-328 5.99e-37

DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.


Pssm-ID: 463855 [Multi-domain]  Cd Length: 158  Bit Score: 131.24  E-value: 5.99e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524715 148 VDCIHVAIKAP---NAEDLSYVNRKGLHSLNCLMVCDIRGTLMTVETNWPGSLQDCAVLQQSSLSSQFEAGMHKDSWLLd 224
Cdd:pfam13359   1 VDGTEIPIQRPsnlEARGQTYSNYKHHNTLKVLIVVTPNGKIIFVSKGYPGSVSDKSILENSGLLKALNLAFGPGDYIL- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462524715 225 lpefhwkdwltvmsrtriystfssvnqGDSSFFLRTWLMTPLHIPE----TPAEYRYNMAHSATHSVIEKTFRTLCSRFR 300
Cdd:pfam13359  80 ---------------------------ADKGFPISDWLLVPYKKPGgaqlSPEEVEFNRRIASARIHVERVIGRLKGRFR 132

                         170       180
                  ....*....|....*....|....*....
gi 2462524715 301 CLdgsKGALQYS-PEKSSHIILACCVLHN 328
Cdd:pfam13359 133 IL---RGRLPISlPERLDKIVTVCCVLHN 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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