|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR1E1-2 |
cd19110 |
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ... |
1-281 |
0e+00 |
|
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 558.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 1 MGDIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATK---PPHPEWIM 77
Cdd:cd19110 1 MEDIPAVGLGTWKASPGEVTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIREKIKEGVVRREDLFIVSKlwcTCHKKSLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 78 --SCSE---------LSFCLSH------PRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLER 140
Cdd:cd19110 81 ktACTRslkalklnyLDLYLIHwpmgfkPGEPDLPLDRSGMVIPSDTDFLDTWEAMEDLVIEGLVKNIGVSNFNHEQLER 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 141 LLNKPGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQ 220
Cdd:cd19110 161 LLNKPGLRVKPVTNQIECHPYLTQKKLISFCQSRNVSVTAYRPLGGSCEGVDLIDDPVIQRIAKKHGKSPAQILIRFQIQ 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462521296 221 RNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFPITKNHKDYPFHIEY 281
Cdd:cd19110 241 RNVIVIPKSVTPSRIKENIQVFDFELTEHDMDNLLSLDRNLRLATFPITENHKDYPFHIEY 301
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
4-281 |
3.05e-148 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 417.20 E-value: 3.05e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATK---PPHPEWIM--S 78
Cdd:cd19107 4 MPILGLGTWKSPPGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQEKIKEQVVKREDLFIVSKlwcTFHEKGLVkgA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 79 CSE---------LSFCLSH------PRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLN 143
Cdd:cd19107 84 CQKtlsdlkldyLDLYLIHwptgfkPGKELFPLDESGNVIPSDTTFLDTWEAMEELVDEGLVKAIGVSNFNHLQIERILN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 144 KPGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLG------GSCEGVDLIDNPVIKRIAKEHGKSPAQILIRF 217
Cdd:cd19107 164 KPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGspdrpwAKPEDPSLLEDPKIKEIAAKHNKTTAQVLIRF 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462521296 218 QIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFPITKNHKDYPFHIEY 281
Cdd:cd19107 244 PIQRNLVVIPKSVTPERIAENFKVFDFELSSEDMATILSFNRNWRACALLSCSSHKDYPFHAEY 307
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
4-254 |
1.69e-109 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 316.73 E-value: 1.69e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIkegaVRREDLFIATK----PPHPEWIMSC 79
Cdd:cd19071 1 MPLIGLGTYKLKPEETAEAVLAALEAGYRHIDTAAAYGNEAEVGEAIRESG----VPREELFITTKlwptDHGYERVREA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 80 SELSfclshprVQDLPLD----------ESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPglRF 149
Cdd:cd19071 77 LEES-------LKDLGLDyldlylihwpVPGKEGGSKEARLETWRALEELVDEGLVRSIGVSNFNVEHLEELLAAA--RI 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 150 KPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSceGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGS 229
Cdd:cd19071 148 KPAVNQIELHPYLQQKELVEFCKEHGIVVQAYSPLGRG--RRPLLDDPVLKEIAKKYGKTPAQVLLRWALQRGVVVIPKS 225
|
250 260
....*....|....*....|....*
gi 2462521296 230 ITPSHIKENIQVFDFELTQHDMDNI 254
Cdd:cd19071 226 SNPERIKENLDVFDFELSEEDMAAI 250
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
3-276 |
4.66e-107 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 312.78 E-value: 4.66e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 3 DIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEG-AVRREDLFIATK----PPHPEWIM 77
Cdd:cd19106 6 KMPLIGLGTWKSKPGQVKAAVKYALDAGYRHIDCAAVYGNEQEVGEALKEKVGPGkAVPREDLFVTSKlwntKHHPEDVE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 78 -SCSE---------LSFCLSH-P----RVQDL-PLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERL 141
Cdd:cd19106 86 pALRKtlkdlqldyLDLYLIHwPyafeRGDNPfPKNPDGTIRYDSTHYKETWKAMEKLVDKGLVKAIGLSNFNSRQIDDI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 142 LNKPglRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGG-------SCEGVdLIDNPVIKRIAKEHGKSPAQIL 214
Cdd:cd19106 166 LSVA--RIKPAVLQVECHPYLAQNELIAHCKARGLVVTAYSPLGSpdrpwakPDEPV-LLEEPKVKALAKKYNKSPAQIL 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462521296 215 IRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFPITKNHKDYP 276
Cdd:cd19106 243 LRWQVQRGVVVIPKSVTPSRIKQNIQVFDFTLSPEEMKQLDALNRNWRYIVPMITVDGKRVP 304
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
4-262 |
5.18e-107 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 312.63 E-value: 5.18e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKAS---PGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKPP----HPEWI 76
Cdd:cd19108 11 IPVLGFGTYAPEevpKSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSKLWctfhRPELV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 77 MSCSELSF----------CLSH------PRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLER 140
Cdd:cd19108 91 RPALEKSLkklqldyvdlYLIHfpvalkPGEELFPKDENGKLIFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEM 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 141 LLNKPGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEG--VD-----LIDNPVIKRIAKEHGKSPAQI 213
Cdd:cd19108 171 ILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGSQRDKewVDqnspvLLEDPVLCALAKKHKRTPALI 250
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2462521296 214 LIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 262
Cdd:cd19108 251 ALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLR 299
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
4-262 |
2.22e-102 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 300.35 E-value: 2.22e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKA-SPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATK----PPHPEWI-- 76
Cdd:cd19116 11 IPAIALGTWKLkDDEGVRQAVKHAIEAGYRHIDTAYLYGNEAEVGEAIREKIAEGVVKREDLFITTKlwnsYHEREQVep 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 77 ---MSCSELSFC-----LSHPRV---QDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNkp 145
Cdd:cd19116 91 alrESLKRLGLDyvdlyLIHWPVafkENNDSESNGDGSLSDIDYLETWRGMEDLVKLGLTRSIGVSNFNSEQINRLLS-- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 146 GLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLG-----GSCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQ 220
Cdd:cd19116 169 NCNIKPAVNQIEVHPTLTQEKLVAYCQSNGIVVMAYSPFGrlvprGQTNPPPRLDDPTLVAIAKKYGKTTAQIVLRYLID 248
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 2462521296 221 RNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 262
Cdd:cd19116 249 RGVVPIPKSSNKKRIKENIDIFDFQLTPEEVAALNSFNTNQR 290
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
4-267 |
3.42e-102 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 298.51 E-value: 3.42e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATK--PPHpewimscse 81
Cdd:COG0656 5 IPALGLGTWQLPGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIA----ASGVPREELFVTTKvwNDN--------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 82 lsfcLSHPRV--------QDLPLDESNMVI---PSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLrfK 150
Cdd:COG0656 72 ----HGYDDTlaafeeslERLGLDYLDLYLihwPGPGPYVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETGV--K 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 151 PLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGgscEGvDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSI 230
Cdd:COG0656 146 PAVNQVELHPYLQQRELLAFCREHGIVVEAYSPLG---RG-KLLDDPVLAEIAEKHGKTPAQVVLRWHLQRGVVVIPKSV 221
|
250 260 270
....*....|....*....|....*....|....*..
gi 2462521296 231 TPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFP 267
Cdd:COG0656 222 TPERIRENLDAFDFELSDEDMAAIDALDRGERLGPDP 258
|
|
| AKR_AKR1D1-3 |
cd19109 |
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ... |
4-277 |
4.38e-97 |
|
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.
Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 287.47 E-value: 4.38e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGL---SSWKASP-GKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATK------PPH- 72
Cdd:cd19109 4 IPIIGLgtySEPKTTPkGACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKIAEGKVKREDIFYCGKlwntchPPEl 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 73 --PEWIMSCSELSF-----------CLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLE 139
Cdd:cd19109 84 vrPTLERTLKVLQLdyvdlyiiempMAFKPGDEIYPRDENGKWLYHKTNLCATWEALEACKDAGLVKSIGVSNFNRRQLE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 140 RLLNKPGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEG--VD-----LIDNPVIKRIAKEHGKSPAQ 212
Cdd:cd19109 164 LILNKPGLKHKPVSNQVECHPYFTQPKLLEFCQQHDIVIVAYSPLGTCRDPiwVNvssppLLEDPLLNSIGKKYNKTAAQ 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462521296 213 ILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFPITKNHKDYPF 277
Cdd:cd19109 244 VVLRFNIQRGVVVIPKSFNPERIKENFQIFDFSLTEEEMKDIEALNKNVRYVELLMWRDHPEYPF 308
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
4-266 |
3.12e-93 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 277.37 E-value: 3.12e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATK-PPH---PEWIMSC 79
Cdd:cd19154 12 MPLIGLGTWQSKGAEGITAVRTALKAGYRLIDTAFLYQNEEAIGEALAELLEEGVVKREDLFITTKlWTHehaPEDVEEA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 80 SELSfcLSHPRVQ--DLPL----------------DESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERL 141
Cdd:cd19154 92 LRES--LKKLQLEyvDLYLihapaafkddegesgtMENGMSIHDAVDVEDVWRGMEKVYDEGLTKAIGVSNFNNDQIQRI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 142 LNKPglRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLG-----------GSCEGVDLIDNPVIKRIAKEHGKSP 210
Cdd:cd19154 170 LDNA--RVKPHNNQVECHLYFPQKELVEFCKKHNISVTSYATLGspgranftkstGVSPAPNLLQDPIVKAIAEKHGKTP 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 2462521296 211 AQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMF 266
Cdd:cd19154 248 AQVLLRYLLQRGIAVIPKSATPSRIKENFNIFDFSLSEEDMATLEEIEKSLRLFLF 303
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
4-263 |
2.03e-89 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 267.74 E-value: 2.03e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATK----PPHPEWIMSC 79
Cdd:cd19123 12 IPALGLGTWKSKPGEVGQAVKQALEAGYRHIDCAAIYGNEAEIGAALAEVFKEGKVKREDLWITSKlwnnSHAPEDVLPA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 80 SE----------LSFCLSHPRV---QDLPLDESN--MVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNK 144
Cdd:cd19123 92 LEktladlqldyLDLYLMHWPValkKGVGFPESGedLLSLSPIPLEDTWRAMEELVDKGLCRHIGVSNFSVKKLEDLLAT 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 145 PglRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLG---------GSCEGVdLIDNPVIKRIAKEHGKSPAQILI 215
Cdd:cd19123 172 A--RIKPAVNQVELHPYLQQPELLAFCRDNGIHLTAYSPLGsgdrpaamkAEGEPV-LLEDPVINKIAEKHGASPAQVLI 248
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2462521296 216 RFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRL 263
Cdd:cd19123 249 AWAIQRGTVVIPKSVNPERIQQNLEAAEVELDASDMATIAALDRHHRY 296
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
4-266 |
2.22e-87 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 262.85 E-value: 2.22e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKPP----HPEWIMSC 79
Cdd:cd19155 12 MPVVGLGTWQSSPEEIETAVDTALEAGYRHIDTAYVYRNEAAIGNVLKKWIDSGKVKREELFIVTKLPpggnRREKVEKF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 80 SELSF----------CLSHPRV-------QDLPLDESN-MVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERL 141
Cdd:cd19155 92 LLKSLeklqldyvdlYLIHFPVgslskedDSGKLDPTGeHKQDYTTDLLDIWKAMEAQVDQGLTRSIGLSNFNREQMARI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 142 LNKPglRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLG-----------GSCEGV--DLIDNPVIKRIAKEHGK 208
Cdd:cd19155 172 LKNA--RIKPANLQVELHVYLQQKDLVDFCSTHSITVTAYAPLGspgaahfspgtGSPSGSspDLLQDPVVKAIAERHGK 249
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 2462521296 209 SPAQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMF 266
Cdd:cd19155 250 SPAQVLLRWLMQRGVVVIPKSTNAARIKENFQVFDFELTEADMAKLSSLDKNIRGRTF 307
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
4-263 |
1.30e-85 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 257.66 E-value: 1.30e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKPphpeWimsCSELS 83
Cdd:cd19125 11 IPAVGLGTWQADPGVVGNAVKTAIKEGYRHIDCAAIYGNEKEIGKALKKLFEDGVVKREDLFITSKL----W---CTDHA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 84 fclsHPRV--------QDLPLD---------------ESNMVIPSD---TDFLDTWEAMEDLVITGLVKNIGVSNFNHEQ 137
Cdd:cd19125 84 ----PEDVppalektlKDLQLDyldlylihwpvrlkkGAHMPEPEEvlpPDIPSTWKAMEKLVDSGKVRAIGVSNFSVKK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 138 LERLLNKPglRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGS---CEGVDLIDNPVIKRIAKEHGKSPAQIL 214
Cdd:cd19125 160 LEDLLAVA--RVPPAVNQVECHPGWQQDKLHEFCKSKGIHLSAYSPLGSPgttWVKKNVLKDPIVTKVAEKLGKTPAQVA 237
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2462521296 215 IRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRL 263
Cdd:cd19125 238 LRWGLQRGTSVLPKSTNEERIKENIDVFDWSIPEEDFAKFSSIEQQRRV 286
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
4-266 |
5.70e-80 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 243.17 E-value: 5.70e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATK-PPH---PEWIMSC 79
Cdd:cd19111 4 MPVIGLGTYQSPPEEVRAAVDYALFVGYRHIDTALSYQNEKAIGEALKWWLKNGKLKREEVFITTKlPPVyleFKDTEKS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 80 SELSF-CLSHPRVqDLPL----------DESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPglR 148
Cdd:cd19111 84 LEKSLeNLKLPYV-DLYLihhpcgfvnkKDKGERELASSDVTSVWRAMEALVSEGKVKSIGLSNFNPRQINKILAYA--K 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 149 FKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGG--------SCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQ 220
Cdd:cd19111 161 VKPSNLQLECHAYLQQRELRKFCNKKNIVVTAYAPLGSpgranqslWPDQPDLLEDPTVLAIAKELDKTPAQVLLRFVLQ 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2462521296 221 RNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMF 266
Cdd:cd19111 241 RGTGVLPKSTNKERIEENFEVFDFELTEEHFKKLKTLDRNMKYFDF 286
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
4-262 |
4.60e-79 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 241.62 E-value: 4.60e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATK---PPHPEWIMSCS 80
Cdd:cd19112 11 MPVIGLGVWRMEPGEIKELILNAIKIGYRHFDCAADYKNEKEVGEALAEAFKTGLVKREDLFITTKlwnSDHGHVIEACK 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 81 E---------LSFCLSHPRV---------QDLPLDESNMV-IPSDTDFLDTWEAMEDLVITGLVKNIGVSNFnheqlERL 141
Cdd:cd19112 91 DslkklqldyLDLYLVHFPVatkhtgvgtTGSALGEDGVLdIDVTISLETTWHAMEKLVSAGLVRSIGISNY-----DIF 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 142 LNKPGL---RFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVDL------IDNPVIKRIAKEHGKSPAQ 212
Cdd:cd19112 166 LTRDCLaysKIKPAVNQIETHPYFQRDSLVKFCQKHGISVTAHTPLGGAAANAEWfgsvspLDDPVLKDLAKKYGKSAAQ 245
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2462521296 213 ILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 262
Cdd:cd19112 246 IVLRWGIQRNTAVIPKSSKPERLKENIDVFDFQLSKEDMKLIKSLDRKYR 295
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
3-258 |
2.34e-77 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 235.34 E-value: 2.34e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 3 DIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKPPHPEWIMSCSEL 82
Cdd:cd19131 9 TIPQLGLGVWQVSNDEAASAVREALEVGYRSIDTAAIYGNEEGVGKAIR----ASGVPREELFITTKLWNSDQGYDSTLR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 83 SFCLSHPRVQ----DLPLDESNMviPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLrfKPLTNQIEC 158
Cdd:cd19131 85 AFDESLRKLGldyvDLYLIHWPV--PAQDKYVETWKALIELKKEGRVKSIGVSNFTIEHLQRLIDETGV--VPVVNQIEL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 159 HPYLTQKNLISFCQSRDVSVTAYRPLGGScegvDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKEN 238
Cdd:cd19131 161 HPRFQQRELRAFHAKHGIQTESWSPLGQG----GLLSDPVIGEIAEKHGKTPAQVVIRWHLQNGLVVIPKSVTPSRIAEN 236
|
250 260
....*....|....*....|
gi 2462521296 239 IQVFDFELTQHDMDNILSLN 258
Cdd:cd19131 237 FDVFDFELDADDMQAIAGLD 256
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
4-258 |
2.26e-75 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 230.40 E-value: 2.26e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTE-AVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKPPHPEWIMSCSEL 82
Cdd:cd19126 9 MPWLGLGVFQTPDGDETErAVQTALENGYRSIDTAAIYKNEEGVGEAIR----ESGVPREELFVTTKLWNDDQRARRTED 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 83 SFclsHPRVQDLPLDESNMVI---PSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPglRFKPLTNQIECH 159
Cdd:cd19126 85 AF---QESLDRLGLDYVDLYLihwPGKDKFIDTWKALEKLYASGKVKAIGVSNFQEHHLEELLAHA--DVVPAVNQVEFH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 160 PYLTQKNLISFCQSRDVSVTAYRPLGGScegvDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKENI 239
Cdd:cd19126 160 PYLTQKELRGYCKSKGIVVEAWSPLGQG----GLLSNPVLAAIGEKYGKSAAQVVLRWDIQHGVVTIPKSVHASRIKENA 235
|
250
....*....|....*....
gi 2462521296 240 QVFDFELTQHDMDNILSLN 258
Cdd:cd19126 236 DIFDFELSEDDMTAIDALN 254
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
4-259 |
5.94e-75 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 230.46 E-value: 5.94e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIrckiKEGAVRREDLFIATK-----PPHPEWIMS 78
Cdd:cd19117 14 IPAVGLGTWQSKPNEVAKAVEAALKAGYRHIDTAAIYGNEEEVGQGI----KDSGVPREEIFITTKlwctwHRRVEEALD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 79 CS-------ELSFCLSH-------PRVQDLPL-DESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLN 143
Cdd:cd19117 90 QSlkklgldYVDLYLMHwpvpldpDGNDFLFKkDDGTKDHEPDWDFIKTWELMQKLPATGKVKAIGVSNFSIKNLEKLLA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 144 KPGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSceGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNV 223
Cdd:cd19117 170 SPSAKIVPAVNQIELHPLLPQPKLVDFCKSKGIHATAYSPLGST--NAPLLKEPVIIKIAKKHGKTPAQVIISWGLQRGY 247
|
250 260 270
....*....|....*....|....*....|....*.
gi 2462521296 224 IVIPGSITPSHIKENIQVfdFELTQHDMDNILSLNR 259
Cdd:cd19117 248 SVLPKSVTPSRIESNFKL--FTLSDEEFKEIDELHK 281
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
4-254 |
6.67e-74 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 226.00 E-value: 6.67e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIrckiKEGAVRREDLFIATKPPHPEW-----IMS 78
Cdd:cd19073 1 IPALGLGTWQLRGDDCANAVKEALELGYRHIDTAEIYNNEAEVGEAI----AESGVPREDLFITTKVWRDHLrpedlKKS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 79 CSElsfCLshprvQDLPLDESNMVI---P-SDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLrfKPLTN 154
Cdd:cd19073 77 VDR---SL-----EKLGTDYVDLLLihwPnPTVPLEETLGALKELKEAGKVKSIGVSNFTIELLEEALDISPL--PIAVN 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 155 QIECHPYLTQKNLISFCQSRDVSVTAYRPLggsCEGvDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSH 234
Cdd:cd19073 147 QVEFHPFLYQAELLEYCRENDIVITAYSPL---ARG-EVLRDPVIQEIAEKYDKTPAQVALRWLVQKGIVVIPKASSEDH 222
|
250 260
....*....|....*....|
gi 2462521296 235 IKENIQVFDFELTQHDMDNI 254
Cdd:cd19073 223 LKENLAIFDWELTSEDVAKI 242
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
4-243 |
8.20e-74 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 227.29 E-value: 8.20e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKE-GAVRREDLFIATK---PPH-PEWI-- 76
Cdd:cd19118 7 IPAIGLGTWQAEPGEVGAAVKIALKAGYRHLDLAKVYQNQHEVGQALKELLKEePGVKREDLFITSKlwnNSHrPEYVep 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 77 --------MSCSELSFCLSH-----PRVQDL------PLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQ 137
Cdd:cd19118 87 alddtlkeLGLDYLDLYLIHwpvafKPTGDLnpltavPTNGGEVDLDLSVSLVDTWKAMVELKKTGKVKSIGVSNFSIDH 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 138 LERLLNKPGLRfkPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVD-LIDNPVIKRIAKEHGKSPAQILIR 216
Cdd:cd19118 167 LQAIIEETGVV--PAVNQIEAHPLLLQDELVDYCKSKNIHITAYSPLGNNLAGLPlLVQHPEVKAIAAKLGKTPAQVLIA 244
|
250 260
....*....|....*....|....*..
gi 2462521296 217 FQIQRNVIVIPGSITPSHIKENIQVFD 243
Cdd:cd19118 245 WGIQRGHSVIPKSVTPSRIRSNFEQVE 271
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
4-257 |
2.38e-73 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 225.59 E-value: 2.38e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTE-AVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATK-PPHP---EWIMS 78
Cdd:cd19136 1 MPILGLGTFRLRGEEEVRqAVDAALKAGYRLIDTASVYRNEADIGKALRDLLPKYGLSREDIFITSKlAPKDqgyEKARA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 79 CSELS----------FCLSH-PRVQDLPldesnmviPSDTDF----LDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLN 143
Cdd:cd19136 81 ACLGSlerlgtdyldLYLIHwPGVQGLK--------PSDPRNaelrRESWRALEDLYKEGKLRAIGVSNYTVRHLEELLK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 144 KPglRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSceGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNV 223
Cdd:cd19136 153 YC--EVPPAVNQVEFHPHLVQKELLKFCKDHGIHLQAYSSLGSG--DLRLLEDPTVLAIAKKYGRTPAQVLLRWALQQGI 228
|
250 260 270
....*....|....*....|....*....|....
gi 2462521296 224 IVIPGSITPSHIKENIQVFDFELTQHDMDNILSL 257
Cdd:cd19136 229 GVIPKSTNPERIAENIKVFDFELSEEDMAELNAL 262
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
4-258 |
3.20e-73 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 224.76 E-value: 3.20e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTE-AVKEAIDAGYRHFDCAYFYHNEREVGAGIrckiKEGAVRREDLFIATKPphpeWIMSCSE- 81
Cdd:cd19133 9 MPILGFGVFQIPDPEECErAVLEAIKAGYRLIDTAAAYGNEEAVGRAI----KKSGIPREELFITTKL----WIQDAGYe 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 82 ---LSFCLSHPRVQdlpldesnmvipsdTDFLD-------------TWEAMEDLVITGLVKNIGVSNFNHEQLERLLnkP 145
Cdd:cd19133 81 kakKAFERSLKRLG--------------LDYLDlylihqpfgdvygAWRAMEELYKEGKIRAIGVSNFYPDRLVDLI--L 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 146 GLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGgscEG-VDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVI 224
Cdd:cd19133 145 HNEVKPAVNQIETHPFNQQIEAVEFLKKYGVQIEAWGPFA---EGrNNLFENPVLTEIAEKYGKSVAQVILRWLIQRGIV 221
|
250 260 270
....*....|....*....|....*....|....
gi 2462521296 225 VIPGSITPSHIKENIQVFDFELTQHDMDNILSLN 258
Cdd:cd19133 222 VIPKSVRPERIAENFDIFDFELSDEDMEAIAALD 255
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
4-262 |
3.46e-73 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 224.96 E-value: 3.46e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGK-VTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIrckiKEGAVRREDLFIATKPPHPEWIMSCSEL 82
Cdd:cd19157 10 MPWLGLGVFKVEEGSeVVNAVKTALKNGYRSIDTAAIYGNEEGVGKGI----KESGIPREELFITSKVWNADQGYDSTLK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 83 SFCLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPglRFKPLTNQIECHPYL 162
Cdd:cd19157 86 AFEASLERLGLDYLDLYLIHWPVKGKYKETWKALEKLYKDGRVRAIGVSNFQVHHLEDLLADA--EIVPMVNQVEFHPRL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 163 TQKNLISFCQSRDVSVTAYRPLggsCEGvDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKENIQVF 242
Cdd:cd19157 164 TQKELRDYCKKQGIQLEAWSPL---MQG-QLLDNPVLKEIAEKYNKSVAQVILRWDLQNGVVTIPKSIKEHRIIENADVF 239
|
250 260
....*....|....*....|
gi 2462521296 243 DFELTQHDMDNILSLNRNLR 262
Cdd:cd19157 240 DFELSQEDMDKIDALNENLR 259
|
|
| AKR_AKR2D1 |
cd19115 |
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ... |
2-262 |
1.34e-71 |
|
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.
Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 222.68 E-value: 1.34e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 2 GDIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATK-------PPHPE 74
Cdd:cd19115 11 YDMPLVGFGLWKVNNDTCADQVYNAIKAGYRLFDGACDYGNEVEAGQGVARAIKEGIVKREDLFIVSKlwntfhdGERVE 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 75 WIMScSELS--------FCLSH---------PRVQDLP--LDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNH 135
Cdd:cd19115 91 PICR-KQLAdwgidyfdLFLIHfpialkyvdPAVRYPPgwFYDGKKVEFSNAPIQETWTAMEKLVDKGLARSIGVSNFSA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 136 EQLERLLNKPglRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLG----------GSCEGVDLIDNPVIKRIAKE 205
Cdd:cd19115 170 QLLMDLLRYA--RIRPATLQIEHHPYLTQPRLVKYAQKEGIAVTAYSSFGpqsfleldlpGAKDTPPLFEHDVIKSIAEK 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 2462521296 206 HGKSPAQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 262
Cdd:cd19115 248 HGKTPAQVLLRWATQRGIAVIPKSNNPKRLAQNLDVTGFDLEAEEIKAISALDIGLR 304
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
3-257 |
1.02e-69 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 215.97 E-value: 1.02e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 3 DIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGirckIKEGAVRREDLFIATK--PPH--PEWIMS 78
Cdd:cd19140 7 RIPALGLGTYPLTGEECTRAVEHALELGYRHIDTAQMYGNEAQVGEA----IAASGVPRDELFLTTKvwPDNysPDDFLA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 79 CSELSfclshprVQDLPLDESNMVI----PSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFkpLTN 154
Cdd:cd19140 83 SVEES-------LRKLRTDYVDLLLlhwpNKDVPLAETLGALNEAQEAGLARHIGVSNFTVALLREAVELSEAPL--FTN 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 155 QIECHPYLTQKNLISFCQSRDVSVTAYRPLGgscEGvDLIDNPVIKRIAKEHGKSPAQILIRFQIQR-NVIVIPGSITPS 233
Cdd:cd19140 154 QVEYHPYLDQRKLLDAAREHGIALTAYSPLA---RG-EVLKDPVLQEIGRKHGKTPAQVALRWLLQQeGVAAIPKATNPE 229
|
250 260
....*....|....*....|....
gi 2462521296 234 HIKENIQVFDFELTQHDMDNILSL 257
Cdd:cd19140 230 RLEENLDIFDFTLSDEEMARIAAL 253
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
4-267 |
1.35e-69 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 216.23 E-value: 1.35e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTE-AVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKPPHPEWIMSCSEL 82
Cdd:cd19156 9 MPRLGLGVWRVQDGAEAEnAVKWAIEAGYRHIDTAAIYKNEEGVGQGIR----ESGVPREEVFVTTKLWNSDQGYESTLA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 83 SFCLShprVQDLPLDESNMVI---PSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRfkPLTNQIECH 159
Cdd:cd19156 85 AFEES---LEKLGLDYVDLYLihwPVKGKFKDTWKAFEKLYKEKKVRAIGVSNFHEHHLEELLKSCKVA--PMVNQIELH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 160 PYLTQKNLISFCQSRDVSVTAYRPLGGScegvDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKENI 239
Cdd:cd19156 160 PLLTQEPLRKFCKEKNIAVEAWSPLGQG----KLLSNPVLKAIGKKYGKSAAQVIIRWDIQHGIITIPKSVHEERIQENF 235
|
250 260
....*....|....*....|....*...
gi 2462521296 240 QVFDFELTQHDMDNILSLNRNLRLAMFP 267
Cdd:cd19156 236 DVFDFELTAEEIRQIDGLNTDHRYGPDP 263
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
2-259 |
5.57e-69 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 214.06 E-value: 5.57e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 2 GDIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKPP----HPEWIM 77
Cdd:cd19132 5 TQIPAIGFGTYPLKGDEGVEAVVAALQAGYRLLDTAFNYENEGAVGEAVR----RSGVPREELFVTTKLPgrhhGYEEAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 78 SCSELSFCLSHPRVQDLPLdesnmvI----PSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLrfKPLT 153
Cdd:cd19132 81 RTIEESLYRLGLDYVDLYL------IhwpnPSRDLYVEAWQALIEAREEGLVRSIGVSNFLPEHLDRLIDETGV--TPAV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 154 NQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGsceGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPS 233
Cdd:cd19132 153 NQIELHPYFPQAEQRAYHREHGIVTQSWSPLGR---GSGLLDEPVIKAIAEKHGKTPAQVVLRWHVQLGVVPIPKSANPE 229
|
250 260
....*....|....*....|....*.
gi 2462521296 234 HIKENIQVFDFELTQHDMDNILSLNR 259
Cdd:cd19132 230 RQRENLAIFDFELSDEDMAAIAALDR 255
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
3-262 |
8.04e-69 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 215.39 E-value: 8.04e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 3 DIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATK-------PPHPEW 75
Cdd:cd19113 10 KMPSVGFGCWKLDNATAADQIYQAIKAGYRLFDGAEDYGNEKEVGEGVNRAIDEGLVKREELFLTSKlwnnfhdPKNVET 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 76 IM--SCSELS------FCLSHPRVQD-LPLDES----------NMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHE 136
Cdd:cd19113 90 ALnkTLSDLKldyvdlFLIHFPIAFKfVPIEEKyppgfycgdgDNFVYEDVPILDTWKALEKLVDAGKIKSIGVSNFPGA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 137 QLERLLNkpGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLG-------GSCEGVD---LIDNPVIKRIAKEH 206
Cdd:cd19113 170 LILDLLR--GATIKPAVLQIEHHPYLQQPKLIEYAQKAGITITAYSSFGpqsfvelNQGRALNtptLFEHDTIKSIAAKH 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 2462521296 207 GKSPAQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 262
Cdd:cd19113 248 NKTPAQVLLRWATQRGIAVIPKSNLPERLLQNLSVNDFDLTKEDFEEIAKLDIGLR 303
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
5-257 |
8.36e-69 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 214.31 E-value: 8.36e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 5 PAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATK--PPH--PEWI---- 76
Cdd:cd19128 2 PRLGFGTYKITESESKEAVKNAIKAGYRHIDCAYYYGNEAFIGIAFSEIFKDGGVKREDLFITSKlwPTMhqPENVkeql 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 77 ------MSCSELSFCLSHPRVQDLPLDESNMVIPSDTDFL------DTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNK 144
Cdd:cd19128 82 litlqdLQLEYLDLFLIHWPLAFDMDTDGDPRDDNQIQSLskkpleDTWRAMEQCVDEKLTKNIGVSNYSTKLLTDLLNY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 145 pgLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSC-EGVDLIDN-PVIKRIAKEHGKSPAQILIRFQIQR- 221
Cdd:cd19128 162 --CKIKPFMNQIECHPYFQNDKLIKFCIENNIHVTAYRPLGGSYgDGNLTFLNdSELKALATKYNTTPPQVIIAWHLQKw 239
|
250 260 270
....*....|....*....|....*....|....*...
gi 2462521296 222 --NVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSL 257
Cdd:cd19128 240 pkNYSVIPKSANKSRCQQNFDINDLALTKEDMDAINTL 277
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
4-257 |
6.05e-67 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 209.69 E-value: 6.05e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIkEGAVRREDLFIATK--PPHPEWIMSCSE 81
Cdd:cd19121 12 IPAVGLGTWQAKAGEVKAAVAHALKIGYRHIDGALCYQNEDEVGEGIKEAI-AGGVKREDLFVTTKlwSTYHRRVELCLD 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 82 LSFCL---------------------SHPRVQDLPlDESNMVIPsDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLER 140
Cdd:cd19121 91 RSLKSlgldyvdlylvhwpvllnpngNHDLFPTLP-DGSRDLDW-DWNHVDTWKQMEKVLKTGKTKAIGVSNYSIPYLEE 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 141 LLnkPGLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSceGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQ 220
Cdd:cd19121 169 LL--KHATVVPAVNQVENHPYLPQQELVDFCKEKGILIEAYSPLGST--GSPLISDEPVVEIAKKHNVGPGTVLISYQVA 244
|
250 260 270
....*....|....*....|....*....|....*..
gi 2462521296 221 RNVIVIPGSITPSHIKENIQVFDFelTQHDMDNILSL 257
Cdd:cd19121 245 RGAVVLPKSVTPDRIKSNLEIIDL--DDEDMNKLNDI 279
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
4-254 |
1.76e-65 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 205.54 E-value: 1.76e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGL---SSWKASPG-----KVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIrckiKEGAVRREDLFIATKpphpew 75
Cdd:cd19120 4 IPAIAFgtgTAWYKSGDddiqrDLVDSVKLALKAGFRHIDTAEMYGNEKEVGEAL----KESGVPREDLFITTK------ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 76 imscseLSFCLSHPR------VQDLPLDESNMVI--------PSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERL 141
Cdd:cd19120 74 ------VSPGIKDPRealrksLAKLGVDYVDLYLihspffakEGGPTLAEAWAELEALKDAGLVRSIGVSNFRIEDLEEL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 142 LNKPglRFKPLTNQIECHPYLT--QKNLISFCQSRDVSVTAYRPLG----GSCEGVDlidnPVIKRIAKEHGKSPAQILI 215
Cdd:cd19120 148 LDTA--KIKPAVNQIEFHPYLYpqQPALLEYCREHGIVVSAYSPLSpltrDAGGPLD----PVLEKIAEKYGVTPAQVLL 221
|
250 260 270
....*....|....*....|....*....|....*....
gi 2462521296 216 RFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNI 254
Cdd:cd19120 222 RWALQKGIVVVTTSSKEERMKEYLEAFDFELTEEEVEEI 260
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
3-258 |
5.93e-65 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 204.18 E-value: 5.93e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 3 DIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKPPHPEWIMSCSEL 82
Cdd:cd19127 8 EMPALGLGVFQTPPEETADAVATALADGYRLIDTAAAYGNEREVGEGIR----RSGVDRSDIFVTTKLWISDYGYDKALR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 83 SFCLSHPRvqdLPLDESNMVI---PSDTDFLDT---WEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGlrFKPLTNQI 156
Cdd:cd19127 84 GFDASLRR---LGLDYVDLYLlhwPVPNDFDRTiqaYKALEKLLAEGRVRAIGVSNFTPEHLERLIDATT--VVPAVNQV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 157 ECHPYLTQKNLISFCQSRDVSVTAYRPLGG--------SCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPG 228
Cdd:cd19127 159 ELHPYFSQKDLRAFHRRLGIVTQAWSPIGGvmrygasgPTGPGDVLQDPTITGLAEKYGKTPAQIVLRWHLQNGVSAIPK 238
|
250 260 270
....*....|....*....|....*....|
gi 2462521296 229 SITPSHIKENIQVFDFELTQHDMDNILSLN 258
Cdd:cd19127 239 SVHPERIAENIDIFDFALSAEDMAAIDALD 268
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
4-263 |
3.16e-63 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 199.91 E-value: 3.16e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIrckiKEGAVRREDLFIATK-----PPHPEWIMS 78
Cdd:PRK11565 15 MPQLGLGVWQASNEEVITAIHKALEVGYRSIDTAAIYKNEEGVGKAL----KEASVAREELFITTKlwnddHKRPREALE 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 79 CSelsfclshprVQDLPLDESNMVI-----PSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLrfKPLT 153
Cdd:PRK11565 91 ES----------LKKLQLDYVDLYLmhwpvPAIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGV--TPVI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 154 NQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGVdlIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPS 233
Cdd:PRK11565 159 NQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKGV--FDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPS 236
|
250 260 270
....*....|....*....|....*....|
gi 2462521296 234 HIKENIQVFDFELTQHDMDNILSLNRNLRL 263
Cdd:PRK11565 237 RIAENFDVFDFRLDKDELGEIAKLDQGKRL 266
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
2-262 |
1.03e-59 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 191.52 E-value: 1.03e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 2 GDIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATK-------PPH-- 72
Cdd:cd19129 4 GAIPALGFGTLIPDPSATRNAVKAALEAGFRHFDCAERYRNEAEVGEAMQEVFKAGKIRREDLFVTTKlwntnhrPERvk 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 73 PEWIMSCSELS------------FCLSHPRVQDlPLDESNMVIPSD-TDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLE 139
Cdd:cd19129 84 PAFEASLKRLQldyldlylihtpFAFQPGDEQD-PRDANGNVIYDDgVTLLDTWRAMERLVDEGRCKAIGLSDVSLEKLR 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 140 RLLNKPglRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGvDLIDNPVIKRIAKEHGKSPAQILIRFQI 219
Cdd:cd19129 163 EIFEAA--RIKPAVVQVESHPYLPEWELLDFCKNHGIVLQAFAPLGHGMEP-KLLEDPVITAIARRVNKTPAQVLLAWAI 239
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 2462521296 220 QRNVIVIPGSITPSHIKENiqvfdFELTQHDMDNILSLNRNLR 262
Cdd:cd19129 240 QRGTALLTTSKTPSRIREN-----FDISTLPEDAMREINEGIK 277
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
4-254 |
4.03e-59 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 189.79 E-value: 4.03e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGL--SSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVR-REDLFIATKP----PHPEWI 76
Cdd:cd19124 5 MPVIGMgtASDPPSPEDIKAAVLEAIEVGYRHFDTAAAYGTEEALGEALAEALRLGLVKsRDELFVTSKLwcsdAHPDLV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 77 MSCseLSFCLSHPRVQ--DL-----PLD---ESNMVIPSDTDFLD-----TWEAMEDLVITGLVKNIGVSNFNHEQLERL 141
Cdd:cd19124 85 LPA--LKKSLRNLQLEyvDLylihwPVSlkpGKFSFPIEEEDFLPfdikgVWEAMEECQRLGLTKAIGVSNFSCKKLQEL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 142 LNKPGLRfkPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGV---DLIDNPVIKRIAKEHGKSPAQILIRFQ 218
Cdd:cd19124 163 LSFATIP--PAVNQVEMNPAWQQKKLREFCKANGIHVTAYSPLGAPGTKWgsnAVMESDVLKEIAAAKGKTVAQVSLRWV 240
|
250 260 270
....*....|....*....|....*....|....*.
gi 2462521296 219 IQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNI 254
Cdd:cd19124 241 YEQGVSLVVKSFNKERMKQNLDIFDWELTEEDLEKI 276
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
4-259 |
1.64e-58 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 188.47 E-value: 1.64e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWkaSP----GKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKPphpeWIMSC 79
Cdd:cd19119 12 IPALGLGTA--SPhedrAEVKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIKRAIDDGSIKREELFITTKV----WPTFY 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 80 SELSFCLSHpRVQDLPLDESNMV-------------------IPSDT----------DFLDTWEAMEDLVITGLVKNIGV 130
Cdd:cd19119 86 DEVERSLDE-SLKALGLDYVDLLlvhwpvcfekdsddsgkpfTPVNDdgktryaasgDHITTYKQLEKIYLDGRAKAIGV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 131 SNFNHEQLERLLNKpgLRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSceGVDLIDNPVIKRIAKEHGKSP 210
Cdd:cd19119 165 SNYSIVYLERLIKE--CKVVPAVNQVELHPHLPQMDLRDFCFKHGILVTAYSPLGSH--GAPNLKNPLVKKIAEKYNVST 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2462521296 211 AQILIRFQIQRNVIVIPGSITPSHIKENIQVfdFELTQHDMDNILSLNR 259
Cdd:cd19119 241 GDILISYHVRQGVIVLPKSLKPVRIVSNGKI--VSLTKEDLQKLDDIGE 287
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
4-258 |
1.80e-58 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 187.43 E-value: 1.80e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKikegAVRREDLFIATKPPHPEWIMSCSELS 83
Cdd:cd19130 10 IPQLGYGVFKVPPADTQRAVATALEVGYRHIDTAAIYGNEEGVGAAIAAS----GIPRDELFVTTKLWNDRHDGDEPAAA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 84 FCLSHPRvqdLPLDESNMVI-----PSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLrfKPLTNQIEC 158
Cdd:cd19130 86 FAESLAK---LGLDQVDLYLvhwptPAAGNYVHTWEAMIELRAAGRTRSIGVSNFLPPHLERIVAATGV--VPAVNQIEL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 159 HPYLTQKNLISFCQSRDVSVTAYRPLG-GScegvdLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKE 237
Cdd:cd19130 161 HPAYQQRTIRDWAQAHDVKIEAWSPLGqGK-----LLGDPPVGAIAAAHGKTPAQIVLRWHLQKGHVVFPKSVRRERMED 235
|
250 260
....*....|....*....|.
gi 2462521296 238 NIQVFDFELTQHDMDNILSLN 258
Cdd:cd19130 236 NLDVFDFDLTDTEIAAIDALD 256
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
4-251 |
1.85e-58 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 187.53 E-value: 1.85e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKaSPGKVTEAVKEAI-DAGYRHFDCAYFYHNEREVGAGIrckiKEGAVRREDLFIATKPPHPEWIMSCSEL 82
Cdd:cd19135 13 MPILGLGTSH-SGGYSHEAVVYALkECGYRHIDTAKRYGCEELLGKAI----KESGVPREDLFLTTKLWPSDYGYESTKQ 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 83 SFCLSHPRVQ----DL-----PLDESNMVIPSDTdFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRfkPLT 153
Cdd:cd19135 88 AFEASLKRLGvdylDLyllhwPDCPSSGKNVKET-RAETWRALEELYDEGLCRAIGVSNFLIEHLEQLLEDCSVV--PHV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 154 NQIECHPYLTQKNLISFCQSRDVSVTAYRPLGgscEGVDLIDNPVIKrIAKEHGKSPAQILIRFQIQRNVIVIPGSITPS 233
Cdd:cd19135 165 NQVEFHPFQNPVELIEYCRDNNIVFEGYCPLA---KGKALEEPTVTE-LAKKYQKTPAQILIRWSIQNGVVTIPKSTKEE 240
|
250
....*....|....*...
gi 2462521296 234 HIKENIQVFDFELTQHDM 251
Cdd:cd19135 241 RIKENCQVFDFSLSEEDM 258
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
2-262 |
2.47e-58 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 188.54 E-value: 2.47e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 2 GD-IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATK----------- 69
Cdd:cd19114 1 GDkMPLVGFGTAKIKANETEEVIYNAIKVGYRLIDGALLYGNEAEVGRGIRKAIQEGLVKREDLFIVTKlwnnfhgkdhv 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 70 -----------------------PPHPEWIMSCSELSFCLSHPRVQDLPLDESNMvipsdtdfLDTWEAMEDLVITGLVK 126
Cdd:cd19114 81 reafdrqlkdygldyidlylihfPIPAAYVDPAENYPFLWKDKELKKFPLEQSPM--------QECWREMEKLVDAGLVR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 127 NIGVSNFNHEQLERLLNKPglRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCEGV---------DLIDNP 197
Cdd:cd19114 153 NIGIANFNVQLILDLLTYA--KIKPAVLQIEHHPYLQQKRLIDWAKKQGIQITAYSSFGNAVYTKvtkhlkhftNLLEHP 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462521296 198 VIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 262
Cdd:cd19114 231 VVKKLADKHKRDTGQVLLRWAVQRNITVIPKSVNVERMKTNLDITSYKLDEEDMEALYELEANAR 295
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
4-257 |
4.42e-56 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 180.63 E-value: 4.42e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKPphpeWIMScsels 83
Cdd:cd19139 1 IPAFGLGTFRLKDDVVIDSVRTALELGYRHIDTAQIYDNEAAVGQAIA----ESGVPRDELFITTKI----WIDN----- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 84 fcLSHPRVQDlPLDES-------------------NMVIPSDtdflDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNK 144
Cdd:cd19139 68 --LSKDKLLP-SLEESleklrtdyvdltlihwpspNDEVPVE----EYIGALAEAKEQGLTRHIGVSNFTIALLDEAIAV 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 145 PGLRfKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGgscEGvDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVI 224
Cdd:cd19139 141 VGAG-AIATNQIELSPYLQNRKLVAHCKQHGIHVTSYMTLA---YG-KVLDDPVLAAIAERHGATPAQIALAWAMARGYA 215
|
250 260 270
....*....|....*....|....*....|...
gi 2462521296 225 VIPGSITPSHIKENIQVFDFELTQHDMDNILSL 257
Cdd:cd19139 216 VIPSSTKREHLRSNLLALDLTLDADDMAAIAAL 248
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
4-263 |
2.96e-55 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 179.28 E-value: 2.96e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKPPHPEWIMSCSELS 83
Cdd:cd19134 11 MPVIGLGVGELSDDEAERSVSAALEAGYRLIDTAAAYGNEAAVGRAIA----ASGIPRGELFVTTKLATPDQGFTASQAA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 84 FCLSHPRvqdLPLDESNMVI-----PSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGlrFKPLTNQIEC 158
Cdd:cd19134 87 CRASLER---LGLDYVDLYLihwpaGREGKYVDSWGGLMKLREEGLARSIGVSNFTAEHLENLIDLTF--FTPAVNQIEL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 159 HPYLTQKNLISFCQSRDVSVTAYRPLG-GScegvdLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKE 237
Cdd:cd19134 162 HPLLNQAELRKVNAQHGIVTQAYSPLGvGR-----LLDNPAVTAIAAAHGRTPAQVLLRWSLQLGNVVISRSSNPERIAS 236
|
250 260
....*....|....*....|....*.
gi 2462521296 238 NIQVFDFELTQHDMDNILSLNRNLRL 263
Cdd:cd19134 237 NLDVFDFELTADHMDALDGLDDGTRF 262
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
4-254 |
1.15e-51 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 170.88 E-value: 1.15e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSW--KASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEG-AVRREDLFIATK-------PPHP 73
Cdd:cd19122 9 IPAVGFGTFanEGAKGETYAAVTKALDVGYRHLDCAWFYLNEDEVGDAVRDFLKENpSVKREDLFICTKvwnhlhePEDV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 74 EWIM--SCSELS-----FCLSHPRVQDLPLDESNMVIPSDTDFL----------DTWEAMEDLVITGLVKNIGVSNFNHE 136
Cdd:cd19122 89 KWSIdnSLKNLKldyidLFLVHWPIAAEKNDQRSPKLGPDGKYVilkdltenpePTWRAMEEIYESGKAKAIGVSNWTIP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 137 QLERLLNKPglRFKPLTNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGSCE----GVDLIDNPVIKRIAKEHGKSPAQ 212
Cdd:cd19122 169 GLKKLLSFA--KVKPHVNQIEIHPFLPNEELVDYCFSNDILPEAYSPLGSQNQvpstGERVSENPTLNEVAEKGGYSLAQ 246
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 2462521296 213 ILIRFQIQRNVIVIPGSITPSHIKENIQVfdFELTQHDMDNI 254
Cdd:cd19122 247 VLIAWGLRRGYVVLPKSSTPSRIESNFKS--IELSDEDFEAI 286
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
6-258 |
1.27e-51 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 170.57 E-value: 1.27e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 6 AVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYH---NEREVGAGIrckiKEGAVRREDLFIATKPP----------H 72
Cdd:pfam00248 7 QLGGGWGPISKEEALEALRAALEAGINFIDTAEVYGdgkSEELLGEAL----KDYPVKRDKVVIATKVPdgdgpwpsggS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 73 PEWIMSCSELSFclshprvQDLPLDESNMV----IPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLr 148
Cdd:pfam00248 83 KENIRKSLEESL-------KRLGTDYIDLYylhwPDPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKALTKGKI- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 149 fKPLTNQIECHPY--LTQKNLISFCQSRDVSVTAYRPLGGS------------CEGVDLIDN-----------PVIKRIA 203
Cdd:pfam00248 155 -PIVAVQVEYNLLrrRQEEELLEYCKKNGIPLIAYSPLGGGlltgkytrdpdkGPGERRRLLkkgtplnlealEALEEIA 233
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 2462521296 204 KEHGKSPAQILIRF--QIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLN 258
Cdd:pfam00248 234 KEHGVSPAQVALRWalSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDELL 290
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
4-254 |
1.49e-50 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 167.02 E-value: 1.49e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWK---------ASPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegAVRREDLFIATK-- 69
Cdd:cd19072 4 VPVLGLGTWGigggmskdySDDKKAIEALRYAIELGINLIDTAEMYgggHAEELVGKAIK------GFDREDLFITTKvs 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 70 PPH---PEWIMSCSElsfclSHPRVQ----DLPL-DESNMVIPsdtdFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERL 141
Cdd:cd19072 78 PDHlkyDDVIKAAKE-----SLKRLGtdyiDLYLiHWPNPSIP----IEETLRAMEELVEEGKIRYIGVSNFSLEELEEA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 142 LNKPGlRFKPLTNQIECHPYLT--QKNLISFCQSRDVSVTAYRPLG-GSCEGVDLIdnPVIKRIAKEHGKSPAQILIRFQ 218
Cdd:cd19072 149 QSYLK-KGPIVANQVEYNLFDReeESGLLPYCQKNGIAIIAYSPLEkGKLSNAKGS--PLLDEIAKKYGKTPAQIALNWL 225
|
250 260 270
....*....|....*....|....*....|....*..
gi 2462521296 219 IQR-NVIVIPGSITPSHIKENIQVFDFELTQHDMDNI 254
Cdd:cd19072 226 ISKpNVIAIPKASNIEHLEENAGALGWELSEEDLQRL 262
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
4-264 |
8.92e-44 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 149.79 E-value: 8.92e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKPphpeWIMSCSELS 83
Cdd:PRK11172 3 IPAFGLGTFRLKDQVVIDSVKTALELGYRAIDTAQIYDNEAAVGQAIA----ESGVPRDELFITTKI----WIDNLAKDK 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 84 FCLS-HPRVQDLPLDESNMVI---PSDTDFLDTWEAMEDLVIT---GLVKNIGVSNFNHEQLERLLNKPGLRfKPLTNQI 156
Cdd:PRK11172 75 LIPSlKESLQKLRTDYVDLTLihwPSPNDEVSVEEFMQALLEAkkqGLTREIGISNFTIALMKQAIAAVGAE-NIATNQI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 157 ECHPYLTQKNLISFCQSRDVSVTAYRPLGgscEGVDLIDnPVIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIK 236
Cdd:PRK11172 154 ELSPYLQNRKVVAFAKEHGIHVTSYMTLA---YGKVLKD-PVIARIAAKHNATPAQVILAWAMQLGYSVIPSSTKRENLA 229
|
250 260
....*....|....*....|....*...
gi 2462521296 237 ENIQVFDFELTQHDMDNILSLNRNLRLA 264
Cdd:PRK11172 230 SNLLAQDLQLDAEDMAAIAALDRNGRLV 257
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
4-252 |
5.22e-41 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 142.32 E-value: 5.22e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWK---------ASPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegAVRREDLFIATK-- 69
Cdd:cd19137 4 IPALGLGTWGiggfltpdySRDEEMVELLKTAIELGYTHIDTAEMYgggHTEELVGKAIK------DFPREDLFIVTKvw 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 70 -------PPHPEWIMSCSELS-----FCLSHPRVQDLPLDEsnmvipsdtdfldTWEAMEDLVITGLVKNIGVSNFNHEQ 137
Cdd:cd19137 78 ptnlrydDLLRSLQNSLRRLDtdyidLYLIHWPNPNIPLEE-------------TLSAMAEGVRQGLIRYIGVSNFNRRL 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 138 LERLLNKpgLRFKPLTNQIECHPY---LTQKNLISFCQSRDVSVTAYRPLGgscEGVDLIdNPVIKRIAKEHGKSPAQIL 214
Cdd:cd19137 145 LEEAISK--SQTPIVCNQVKYNLEdrdPERDGLLEYCQKNGITVVAYSPLR---RGLEKT-NRTLEEIAKNYGKTIAQIA 218
|
250 260 270
....*....|....*....|....*....|....*....
gi 2462521296 215 IRFQIQR-NVIVIPGSITPSHIKENIQVFDFELTQHDMD 252
Cdd:cd19137 219 LAWLIQKpNVVAIPKAGRVEHLKENLKATEIKLSEEEMK 257
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
4-254 |
7.19e-39 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 136.99 E-value: 7.19e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSW-----KASPGKVTEAVKEAIDAGYRHFDCAYFYHN---EREVGAGIRCkikegavRREDLFIATK--PPH- 72
Cdd:cd19138 11 VPALGQGTWymgedPAKRAQEIEALRAGIDLGMTLIDTAEMYGDggsEELVGEAIRG-------RRDKVFLVSKvlPSNa 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 73 -PEWIMSCSELSfcLSHprvqdLPLDESNMVI---PSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLR 148
Cdd:cd19138 84 sRQGTVRACERS--LRR-----LGTDYLDLYLlhwRGGVPLAETVAAMEELKKEGKIRAWGVSNFDTDDMEELWAVPGGG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 149 fKPLTNQIECHpyLTQKN----LISFCQSRDVSVTAYRPLG-GSCEGVDLIDNPVIKRIAKEHGKSPAQILIRFQI-QRN 222
Cdd:cd19138 157 -NCAANQVLYN--LGSRGieydLLPWCREHGVPVMAYSPLAqGGLLRRGLLENPTLKEIAARHGATPAQVALAWVLrDGN 233
|
250 260 270
....*....|....*....|....*....|..
gi 2462521296 223 VIVIPGSITPSHIKENIQVFDFELTQHDMDNI 254
Cdd:cd19138 234 VIAIPKSGSPEHARENAAAADLELTEEDLAEL 265
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
8-254 |
5.65e-35 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 127.99 E-value: 5.65e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 8 GLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegAVRREDLFIATK-------PPH----- 72
Cdd:COG0667 24 GGPWGGVDEAEAIAILDAALDAGINFFDTADVYgpgRSEELLGEALK------GRPRDDVVIATKvgrrmgpGPNgrgls 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 73 PEWIMSCselsfclshprvqdlpLDES--NM-----------VIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLE 139
Cdd:COG0667 98 REHIRRA----------------VEASlrRLgtdyidlyqlhRPDPDTPIEETLGALDELVREGKIRYIGVSNYSAEQLR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 140 RLLNKPGLRFKPLTNQIEchpY--LTQ---KNLISFCQSRDVSVTAYRPLGG---------------------------- 186
Cdd:COG0667 162 RALAIAEGLPPIVAVQNE---YslLDRsaeEELLPAARELGVGVLAYSPLAGglltgkyrrgatfpegdraatnfvqgyl 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 187 SCEGVDLIDnpVIKRIAKEHGKSPAQILIRFQIQR--NVIVIPGSITPSHIKENIQVFDFELTQHDMDNI 254
Cdd:COG0667 239 TERNLALVD--ALRAIAAEHGVTPAQLALAWLLAQpgVTSVIPGARSPEQLEENLAAADLELSAEDLAAL 306
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
4-254 |
4.50e-28 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 109.15 E-value: 4.50e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASP---GKVTE-----AVKEAIDAGYRHFDCAYFY---HNEREVGAGIrckikegAVRREDLFIATK--- 69
Cdd:cd19084 4 VSRIGLGTWAIGGtwwGEVDDqesieAIKAAIDLGINFFDTAPVYgfgHSEEILGKAL-------KGRRDDVVIATKcgl 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 70 ----PPH------PEWIMSCSELSfcLShpRVQ----DL-----PlDEsnmvipsDTDFLDTWEAMEDLVITGLVKNIGV 130
Cdd:cd19084 77 rwdgGKGvtkdlsPESIRKEVEQS--LR--RLQtdyiDLyqihwP-DP-------NTPIEETAEALEKLKKEGKIRYIGV 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 131 SNFNHEQLERLLNkpglRFKPLTNQIechPY--LTQKN---LISFCQSRDVSVTAYRPLGG------------------- 186
Cdd:cd19084 145 SNFSVEQLEEARK----YGPIVSLQP---PYsmLEREIeeeLLPYCRENGIGVLPYGPLAQglltgkykkeptfppddrr 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 187 ------SCE----GVDLIDnpVIKRIAKEHGKSPAQILIRFQIQRN--VIVIPGSITPSHIKENIQVFDFELTQHDMDNI 254
Cdd:cd19084 218 srfpffRGEnfekNLEIVD--KLKEIAEKYGKSLAQLAIAWTLAQPgvTSAIVGAKNPEQLEENAGALDWELTEEELKEI 295
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
4-251 |
9.82e-27 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 105.39 E-value: 9.82e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKA-----------SPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIrckiKEGAVRrEDLFIATK 69
Cdd:cd19093 2 VSPLGLGTWQWgdrlwwgygeyGDEDLQAAFDAALEAGVNLFDTAEVYgtgRSERLLGRFL----KELGDR-DEVVIATK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 70 --PPHPEWIMSCSELSFCLSHPRVQ----DLPLDESNMVIPSDTDFLdtWEAMEDLVITGLVKNIGVSNFNHEQLERLLN 143
Cdd:cd19093 77 faPLPWRLTRRSVVKALKASLERLGldsiDLYQLHWPGPWYSQIEAL--MDGLADAVEEGLVRAVGVSNYSADQLRRAHK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 144 KPGLRFKPL-TNQIE---CHPYLTQKNLISFCQSRDVSVTAYRPLG-GSCEGVDLIDNP--------------------- 197
Cdd:cd19093 155 ALKERGVPLaSNQVEyslLYRDPEQNGLLPACDELGITLIAYSPLAqGLLTGKYSPENPppggrrrlfgrknlekvqpll 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 2462521296 198 -VIKRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDM 251
Cdd:cd19093 235 dALEEIAEKYGKTPAQVALNWLIAKGVVPIPGAKNAEQAEENAGALGWRLSEEEV 289
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
8-247 |
1.42e-26 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 104.95 E-value: 1.42e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 8 GLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHN---EREVGAGIrckiKEGAVRREDLFIATK-------PPHPEWIM 77
Cdd:cd19092 15 RLADWGESAEELLSLIEAALELGITTFDHADIYGGgkcEELFGEAL----ALNPGLREKIEIQTKcgirlgdDPRPGRIK 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 78 ScselsFCLSHPRVQDlPLDES--NMvipsDTDFLD---------------TWEAMEDLVITGLVKNIGVSNFNHEQLEr 140
Cdd:cd19092 91 H-----YDTSKEHILA-SVEGSlkRL----GTDYLDllllhrpdplmdpeeVAEAFDELVKSGKVRYFGVSNFTPSQIE- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 141 LLNKpGLRFKPLTNQIEC---HPYLTQKNLISFCQSRDVSVTAYRPL-GGSCEGVDLID----NPVIKRIAKEHGKSPAQ 212
Cdd:cd19092 160 LLQS-YLDQPLVTNQIELsllHTEAIDDGTLDYCQLLDITPMAWSPLgGGRLFGGFDERfqrlRAALEELAEEYGVTIEA 238
|
250 260 270
....*....|....*....|....*....|....*...
gi 2462521296 213 ILIRFqIQR---NVIVIPGSITPSHIKENIQVFDFELT 247
Cdd:cd19092 239 IALAW-LLRhpaRIQPILGTTNPERIRSAVKALDIELT 275
|
|
| YdhF |
COG4989 |
Predicted oxidoreductase YdhF [General function prediction only]; |
8-250 |
1.30e-25 |
|
Predicted oxidoreductase YdhF [General function prediction only];
Pssm-ID: 444013 [Multi-domain] Cd Length: 299 Bit Score: 102.54 E-value: 1.30e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 8 GLSSWKASPGKVTEAVKEAIDAGYRHFDCA--Y-FYHNEREVGAGIrckiKEGAVRREDLFIATK----PPHP------- 73
Cdd:COG4989 22 RLGEWDLSPAEAAALIEAALELGITTFDHAdiYgGYTCEALFGEAL----KLSPSLREKIELQTKcgirLPSEardnrvk 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 74 ------EWIMSCSELSfclshprVQDLpldesnmvipsDTDFLDTW---------------EAMEDLVITGLVKNIGVSN 132
Cdd:COG4989 98 hydtskEHIIASVEGS-------LRRL-----------GTDYLDLLllhrpdplmdpeevaEAFDELKASGKVRHFGVSN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 133 FNHEQLErLLNKpGLRFKPLTNQIECHpyLTQKNLIS-----FCQSRDVSVTAYRPL-GGSCEGVDLIDNP----VIKRI 202
Cdd:COG4989 160 FTPSQFE-LLQS-ALDQPLVTNQIELS--LLHTDAFDdgtldYCQLNGITPMAWSPLaGGRLFGGFDEQFPrlraALDEL 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 2462521296 203 AKEHGKSPAQILIRFqIQR---NVIVIPGSITPSHIKENIQVFDFELTQHD 250
Cdd:COG4989 236 AEKYGVSPEAIALAW-LLRhpaGIQPVIGTTNPERIKAAAAALDIELTREE 285
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
4-254 |
2.80e-25 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 101.51 E-value: 2.80e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWKASPGKVTE---------AVKEAIDAGYRHFDCAYFY---HNEREVGAGIrckikEGavRREDLFIATK-- 69
Cdd:cd19085 1 VSRLGLGCWQFGGGYWWGdqddeesiaTIHAALDAGINFFDTAEAYgdgHSEEVLGKAL-----KG--RRDDVVIATKvs 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 70 --PPHPEWImscsELSFCLSHPRVQ----DL-----PldesnmviPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQL 138
Cdd:cd19085 74 pdNLTPEDV----RKSCERSLKRLGtdyiDLyqihwP--------SSDVPLEETMEALEKLKEEGKIRAIGVSNFGPAQL 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 139 ERLLNkpglRFKPLTNQIECHPYLTQ--KNLISFCQSRDVSVTAYRP-----LGG------------------------- 186
Cdd:cd19085 142 EEALD----AGRIDSNQLPYNLLWRAieYEILPFCREHGIGVLAYSPlaqglLTGkfssaedfppgdartrlfrhfepga 217
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462521296 187 ---SCEGVDLidnpvIKRIAKEHGKSPAQILIRFQIQRNVI--VIPGSITPSHIKENIQVFDFELTQHDMDNI 254
Cdd:cd19085 218 eeeTFEALEK-----LKEIADELGVTMAQLALAWVLQQPGVtsVIVGARNPEQLEENAAAVDLELSPSVLERL 285
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
21-240 |
5.00e-25 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 99.52 E-value: 5.00e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 21 EAVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikeGAVRREDLFIATKPPHPEWimsCSELSFCLSHPRV-QDLpl 96
Cdd:cd06660 21 ALLDAALEAGGNFFDTADVYgdgRSERLLGRWLK-----GRGNRDDVVIATKGGHPPG---GDPSRSRLSPEHIrRDL-- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 97 DES--NMvipsDTDFLD---------------TWEAMEDLVITGLVKNIGVSNFNHEQLERLLN--KPGLRFKPLTNQIE 157
Cdd:cd06660 91 EESlrRL----GTDYIDlyylhrddpstpveeTLEALNELVREGKIRYIGVSNWSAERLAEALAyaKAHGLPGFAAVQPQ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 158 ---CHPYLTQKNLISFCQSRDVSVTAYRPLGGsceGvdlidnpvikriakehgksPAQILIRFQIQR--NVIVIPGSITP 232
Cdd:cd06660 167 yslLDRSPMEEELLDWAEENGLPLLAYSPLAR---G-------------------PAQLALAWLLSQpfVTVPIVGARSP 224
|
....*...
gi 2462521296 233 SHIKENIQ 240
Cdd:cd06660 225 EQLEENLA 232
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
6-254 |
3.37e-20 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 88.11 E-value: 3.37e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 6 AVGLSSWKASPGKVTE-----AVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegaVRREDLFIATKPPhPEWiM 77
Cdd:cd19102 10 AIGGGGWGGGWGPQDDrdsiaAIRAALDLGINWIDTAAVYglgHSEEVVGRALK-------GLRDRPIVATKCG-LLW-D 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 78 SCSELSFCL-----------SHPRVQDLPLDESNMVIPS-DTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLlnkp 145
Cdd:cd19102 81 EEGRIRRSLkpasiraeceaSLRRLGVDVIDLYQIHWPDpDEPIEEAWGALAELKEEGKVRAIGVSNFSVDQMKRC---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 146 gLRFKPLT-NQIechPYL-----TQKNLISFCQSRDVSVTAYRPLG-GSCEG---------------------------- 190
Cdd:cd19102 157 -QAIHPIAsLQP---PYSllrrgIEAEILPFCAEHGIGVIVYSPMQsGLLTGkmtpervaslpaddwrrrspffqepnla 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462521296 191 --VDLIDnpVIKRIAKEHGKSPAQILIRFQIQRNVI--VIPGSITPSHIKENIQVFDFELTQHDMDNI 254
Cdd:cd19102 233 rnLALVD--ALRPIAERHGRTVAQLAIAWVLRRPEVtsAIVGARRPDQIDETVGAADLRLTPEELAEI 298
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
12-252 |
5.48e-20 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 87.64 E-value: 5.48e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 12 WKASPGKVTEAVKEAIDAGYRHFDCAYFYHN---EREVGAGIRckikeGAVRREDLFIATKPPHP------------EWI 76
Cdd:cd19079 30 WVLDEEESRPIIKRALDLGINFFDTANVYSGgasEEILGRALK-----EFAPRDEVVIATKVYFPmgdgpngrglsrKHI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 77 MSCSELSfcLShpRVQ----DL----PLDEsnmvipsDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLN---KP 145
Cdd:cd19079 105 MAEVDAS--LK--RLGtdyiDLyqihRWDY-------ETPIEETLEALHDVVKSGKVRYIGASSMYAWQFAKALHlaeKN 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 146 GL-RFKPLTNQ-------IEchpyltqKNLISFCQSRDVSVTAYRPL------GGSCEGVDLI----------------- 194
Cdd:cd19079 174 GWtKFVSMQNHynllyreEE-------REMIPLCEEEGIGVIPWSPLargrlaRPWGDTTERRrsttdtaklkydyftea 246
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462521296 195 DNPVIKR---IAKEHGKSPAQILIRFQIQRNVIVIP--GSITPSHIKENIQVFDFELTQHDMD 252
Cdd:cd19079 247 DKEIVDRveeVAKERGVSMAQVALAWLLSKPGVTAPivGATKLEHLEDAVAALDIKLSEEEIK 309
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
23-247 |
1.66e-18 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 82.65 E-value: 1.66e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 23 VKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegaVRREDLFIATK-----------PPH--PEWIMSCSELSfcL 86
Cdd:cd19088 30 LRRALELGVNFIDTADSYgpdVNERLIAEALH-------PYPDDVVIATKgglvrtgpgwwGPDgsPEYLRQAVEAS--L 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 87 SHPRVQDLPLDESNmVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLrfkpLTNQIECHPYLTQ-K 165
Cdd:cd19088 101 RRLGLDRIDLYQLH-RIDPKVPFEEQLGALAELQDEGLIRHIGLSNVTVAQIEEARAIVRI----VSVQNRYNLANRDdE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 166 NLISFCQSRDVSVTAYRPLGGsceGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQR--NVIVIPGSITPSHIKENIQVFD 243
Cdd:cd19088 176 GVLDYCEAAGIAFIPWFPLGG---GDLAQPGGLLAEVAARLGATPAQVALAWLLARspVMLPIPGTSSVEHLEENLAAAG 252
|
....
gi 2462521296 244 FELT 247
Cdd:cd19088 253 LRLS 256
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
14-254 |
1.30e-17 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 80.72 E-value: 1.30e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 14 ASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATK--PPHPEWIMSCSE----LSFCLS 87
Cdd:cd19101 20 RDEDAAVRAMAAYVDAGLTTFDCADIYGPAEELIGEFRKRLRRERDAADDVQIHTKwvPDPGELTMTRAYveaaIDRSLK 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 88 HPRVQDLPL------DesnmviPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPglrFKPLTNQIEC--- 158
Cdd:cd19101 100 RLGVDRLDLvqfhwwD------YSDPGYLDAAKHLAELQEEGKIRHLGLTNFDTERLREILDAG---VPIVSNQVQYsll 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 159 --HPyltQKNLISFCQSRDVSVTAYRPLGG----------------SCEGVDL------IDN-----------PVIKRIA 203
Cdd:cd19101 171 drRP---ENGMAALCEDHGIKLLAYGTLAGgllsekylgvpeptgpALETRSLqkyklmIDEwggwdlfqellRTLKAIA 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 2462521296 204 KEHGKSPAQILIRFQIQRNVI--VIPGSITPSHIKENIQVFDFELTQHDMDNI 254
Cdd:cd19101 248 DKHGVSIANVAVRWVLDQPGVagVIVGARNSEHIDDNVRAFSFRLDDEDRAAI 300
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
24-254 |
6.12e-16 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 76.10 E-value: 6.12e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 24 KEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegaVRREDLFIATK--------PPH------PEWIMSCSELSfcl 86
Cdd:cd19076 39 HRALELGVTFLDTADMYgpgTNEELLGKALK-------DRRDEVVIATKfgivrdpgSGFrgvdgrPEYVRAACEAS--- 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 87 shprVQDLPLDESNMV----IPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERllnkpGLRFKPLTN-QIECHPY 161
Cdd:cd19076 109 ----LKRLGTDVIDLYyqhrVDPNVPIEETVGAMAELVEEGKVRYIGLSEASADTIRR-----AHAVHPITAvQSEYSLW 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 162 LT--QKNLISFCQSRDVSVTAYRPLG-----GSCEGVDLID-------NP---------------VIKRIAKEHGKSPAQ 212
Cdd:cd19076 180 TRdiEDEVLPTCRELGIGFVAYSPLGrgfltGAIKSPEDLPeddfrrnNPrfqgenfdknlklveKLEAIAAEKGCTPAQ 259
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 2462521296 213 ILIRFQIQR--NVIVIPGSITPSHIKENIQVFDFELTQHDMDNI 254
Cdd:cd19076 260 LALAWVLAQgdDIVPIPGTKRIKYLEENVGALDVVLTPEELAEI 303
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
4-241 |
1.49e-15 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 74.05 E-value: 1.49e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSW--------KASPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGagircKIKEGavRREDLFIATKPPH 72
Cdd:cd19086 3 VSEIGFGTWglggdwwgDVDDAEAIRALRAALDLGINFFDTADVYgdgHSERLLG-----KALKG--RRDKVVIATKFGN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 73 -------------PEWIMSCSELS----------FCLSH-PRVQDLPLDEsnmvipsdtdfldTWEAMEDLVITGLVKNI 128
Cdd:cd19086 76 rfdggperpqdfsPEYIREAVEASlkrlgtdyidLYQLHnPPDEVLDNDE-------------LFEALEKLKQEGKIRAY 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 129 GVSNFNHEQLERLLNKPG-----LRFkpltNQIECHPYLTqknLISFCQSRDVSVTAYRPLggsCEGVdLIdnpvikria 203
Cdd:cd19086 143 GVSVGDPEEALAALRRGGidvvqVIY----NLLDQRPEEE---LFPLAEEHGVGVIARVPL---ASGL-LT--------- 202
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2462521296 204 kehGKsPAQILIRFQIQRNVI--VIPGSITPSHIKENIQV 241
Cdd:cd19086 203 ---GK-LAQAALRFILSHPAVstVIPGARSPEQVEENAAA 238
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
23-257 |
2.90e-15 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 74.38 E-value: 2.90e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 23 VKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegAVRREDLFIATKPPH------------PEWIMSCSELSFcls 87
Cdd:cd19083 39 VREALDNGVNLLDTAFIYglgRSEELVGEVLK------EYNRNEVVIATKGAHkfggdgsvlnnsPEFLRSAVEKSL--- 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 88 hPRVQDLPLDESNMVIPS-DTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERlLNKPGlrfkpLTNQIEcHPY-LTQ- 164
Cdd:cd19083 110 -KRLNTDYIDLYYIHFPDgETPKAEAVGALQELKDEGKIRAIGVSNFSLEQLKE-ANKDG-----YVDVLQ-GEYnLLQr 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 165 ---KNLISFCQSRDVSVTAYRPL------GGSCEGVDLIDNPV---------------------IKRIAKEHGKSPAQIL 214
Cdd:cd19083 182 eaeEDILPYCVENNISFIPYFPLasgllaGKYTKDTKFPDNDLrndkplfkgerfsenldkvdkLKSIADEKGVTVAHLA 261
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2462521296 215 IRFQIQRNVI--VIPGSITPSHIKENIQVFDFELTQHDMDNILSL 257
Cdd:cd19083 262 LAWYLTRPAIdvVIPGAKRAEQVIDNLKALDVTLTEEEIAFIDAL 306
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
14-241 |
9.63e-15 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 71.85 E-value: 9.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 14 ASPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegAVRREDLFIATKPPHPEWIMSCSEL--SFCLSH 88
Cdd:cd19105 22 GLPRESPELLRRALDLGINYFDTAEGYgngNSEEIIGEALK------GLRRDKVFLATKASPRLDKKDKAELlkSVEESL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 89 PRVQdlpldesnmvipsdTDFLDTW------------------EAMEDLVITGLVKNIGVS--NFNHEQLERLLNKPG-- 146
Cdd:cd19105 96 KRLQ--------------TDYIDIYqlhgvdtpeerllneellEALEKLKKEGKVRFIGFSthDNMAEVLQAAIESGWfd 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 147 ---LRFKPLtnqiecHPYLTQKNLISFCQSRDVSVTAYRPLGGscegvdLIDNPVIKRIAKEHGKSPAQILIRFQIQRNV 223
Cdd:cd19105 162 vimVAYNFL------NQPAELEEALAAAAEKGIGVVAMKTLAG------GYLQPALLSVLKAKGFSLPQAALKWVLSNPR 229
|
250 260
....*....|....*....|
gi 2462521296 224 I--VIPGSITPSHIKENIQV 241
Cdd:cd19105 230 VdtVVPGMRNFAELEENLAA 249
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
12-252 |
1.13e-13 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 69.95 E-value: 1.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 12 WKASPGKVTEA-----VKEAIDAGYRHFDCAYFYHN---EREVGAGIRCkikegavRREDLFIATKpphpewimscseLS 83
Cdd:cd19091 29 FFGAWGGVDQEeadrlVDIALDAGINFFDTADVYSEgesEEILGKALKG-------RRDDVLIATK------------VR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 84 FCLShPRVQDLPLDESNMVIPSD-------TDFLD---------------TWEAMEDLVITGLVKNIGVSNFNHEQLERL 141
Cdd:cd19091 90 GRMG-EGPNDVGLSRHHIIRAVEaslkrlgTDYIDlyqlhgfdaltpleeTLRALDDLVRQGKVRYIGVSNFSAWQIMKA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 142 L---NKPGLRfKPLTNQIechpYLT------QKNLISFCQSRDVSVTAYRPLGGSC------------------------ 188
Cdd:cd19091 169 LgisERRGLA-RFVALQA----YYSllgrdlEHELMPLALDQGVGLLVWSPLAGGLlsgkyrrgqpapegsrlrrtgfdf 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462521296 189 ------EGVDLIDnpVIKRIAKEHGKSPAQILIRFQIQRNVI--VIPGSITPSHIKENIQVFDFELTQHDMD 252
Cdd:cd19091 244 ppvdreRGYDVVD--ALREIAKETGATPAQVALAWLLSRPTVssVIIGARNEEQLEDNLGAAGLSLTPEEIA 313
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
5-241 |
1.66e-13 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 68.42 E-value: 1.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 5 PAVGLSSWK--ASPGKVTEA-----VKEAIDAGYRHFDCAYFYHN-EREVGAGIRckikegAVRREDLFIATK------- 69
Cdd:cd19095 1 SVLGLGTSGigRVWGVPSEAeaarlLNTALDLGINLIDTAPAYGRsEERLGRALA------GLRRDDLFIATKvgthgeg 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 70 -PPHPEWIMSCSELSFCLSHPRVQ----DLpldesnMVIPSDTDFL---DTWEAMEDLVITGLVKNIGVSNFNHEqLERL 141
Cdd:cd19095 75 gRDRKDFSPAAIRASIERSLRRLGtdyiDL------LQLHGPSDDEltgEVLETLEDLKAAGKVRYIGVSGDGEE-LEAA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 142 LNKPGLRFkpltnqIEChPY----LTQKNLISFCQSRDVSVTAYRPLGGSC-------EGVDLIDNPVIKRIAKEHGKSP 210
Cdd:cd19095 148 IASGVFDV------VQL-PYnvldREEEELLPLAAEAGLGVIVNRPLANGRlrrrvrrRPLYADYARRPEFAAEIGGATW 220
|
250 260 270
....*....|....*....|....*....|...
gi 2462521296 211 AQILIRFQIQ--RNVIVIPGSITPSHIKENIQV 241
Cdd:cd19095 221 AQAALRFVLShpGVSSAIVGTTNPEHLEENLAA 253
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
13-243 |
2.35e-13 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 67.97 E-value: 2.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 13 KASPGKVTEAVKEAIDAGYRHFDCAYFYHN---EREVGAGIRckikegAVRREDLFIATKPPHpeWIMSCSElSFclshp 89
Cdd:cd19096 17 SIDEEKAIEMIRYAIDAGINYFDTAYGYGGgksEEILGEALK------EGPREKFYLATKLPP--WSVKSAE-DF----- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 90 rvqDLPLDES--NMvipsDTDFLD--------------------TWEAMEDLVITGLVKNIGVSnFnH---EQLERLLNK 144
Cdd:cd19096 83 ---RRILEESlkRL----GVDYIDfyllhglnspewlekarkggLLEFLEKAKKEGLIRHIGFS-F-HdspELLKEILDS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 145 PGLRFkpltNQIECHpYLTQKN-----LISFCQSRDVSVTAYRPLGGsceGVDLIDNPVIKRIAKEHGKSPAQILIRFQI 219
Cdd:cd19096 154 YDFDF----VQLQYN-YLDQENqagrpGIEYAAKKGMGVIIMEPLKG---GGLANNPPEALAILCGAPLSPAEWALRFLL 225
|
250 260
....*....|....*....|....*.
gi 2462521296 220 -QRNV-IVIPGSITPSHIKENIQVFD 243
Cdd:cd19096 226 sHPEVtTVLSGMSTPEQLDENIAAAD 251
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
11-254 |
2.37e-13 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 68.80 E-value: 2.37e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 11 SWKASP---GKVTEAVKEAIDAGYRHFDCAYFY------HNEREVGAGIRcKIKEgavRREDLFI--------ATKPPH- 72
Cdd:cd19077 16 TWRPNPtpdEEAFETMKAALDAGSNLWNGGEFYgppdphANLKLLARFFR-KYPE---YADKVVLsvkggldpDTLRPDg 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 73 -PEWIMScsELSFCLSHPRVQDlPLDESNM-VIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERllnkpGLRFK 150
Cdd:cd19077 92 sPEAVRK--SIENILRALGGTK-KIDIFEPaRVDPNVPIEETIKALKELVKEGKIRGIGLSEVSAETIRR-----AHAVH 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 151 PLT-NQIECHPYLT---QKNLISFCQSRDVSVTAYRPLG-GSCEG-----VDLIDNPV---------------------I 199
Cdd:cd19077 164 PIAaVEVEYSLFSReieENGVLETCAELGIPIIAYSPLGrGLLTGrikslADIPEGDFrrhldrfngenfeknlklvdaL 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 2462521296 200 KRIAKEHGKSPAQIL---IRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNI 254
Cdd:cd19077 244 QELAEKKGCTPAQLAlawILAQSGPKIIPIPGSTTLERVEENLKAANVELTDEELKEI 301
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
18-265 |
3.00e-13 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 68.69 E-value: 3.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 18 KVTEAVKEAIDAGYRHFDCAYFYHN-EREVGAGIRCkikegavRREDLFIATKpphpewimscselsfclSHPRVQDLP- 95
Cdd:COG1453 30 EAEALIRRAIDNGINYIDTARGYGDsEEFLGKALKG-------PRDKVILATK-----------------LPPWVRDPEd 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 96 ----LDES--NMvipsDTDFLD---------------------TWEAMEDLVITGLVKNIGVSnfNH---EQLERLLNkp 145
Cdd:COG1453 86 mrkdLEESlkRL----QTDYIDlylihglnteedlekvlkpggALEALEKAKAEGKIRHIGFS--THgslEVIKEAID-- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 146 glrfkplTNQIEC----HPYLTQKN-----LISFCQSRDVSVTAYRPLGGsceGvDLIDNP-VIKRIAkEHGKSPAQILI 215
Cdd:COG1453 158 -------TGDFDFvqlqYNYLDQDNqageeALEAAAEKGIGVIIMKPLKG---G-RLANPPeKLVELL-CPPLSPAEWAL 225
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 2462521296 216 RF--QIQRNVIVIPGSITPSHIKENIQVFD-FE-LTQHDMDNILSLNRNLRLAM 265
Cdd:COG1453 226 RFllSHPEVTTVLSGMSTPEQLDENLKTADnLEpLTEEELAILERLAEELGELL 279
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
60-252 |
3.12e-13 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 68.39 E-value: 3.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 60 RREDLFIATK---PP-------HPEWIMSCSELS----------FCLSHPRVQDLPLDEsnmvipsdtdfldTWEAMEDL 119
Cdd:cd19081 74 KRDRVVIATKvgfPMgpngpglSRKHIRRAVEASlrrlqtdyidLYQAHWDDPATPLEE-------------TLGALNDL 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 120 VITGLVKNIGVSNFNHEQLERLLN---KPGL-RF---KPLTNQIECHPYltQKNLISFCQSRDVSVTAYRPLGG------ 186
Cdd:cd19081 141 IRQGKVRYIGASNYSAWRLQEALElsrQHGLpRYvslQPEYNLVDRESF--EGELLPLCREEGIGVIPYSPLAGgfltgk 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 187 ------------SCEGVDLIDNP-------VIKRIAKEHGKSPAQILIRFQIQRNVI--VIPGSITPSHIKENIQVFDFE 245
Cdd:cd19081 219 yrseadlpgstrRGEAAKRYLNErglrildALDEVAAEHGATPAQVALAWLLARPGVtaPIAGARTVEQLEDLLAAAGLR 298
|
....*..
gi 2462521296 246 LTQHDMD 252
Cdd:cd19081 299 LTDEEVA 305
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
7-248 |
5.37e-12 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 64.54 E-value: 5.37e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 7 VGLSSWKASPGKVT-----EAVKEAIDAGYRHFDCAYFYHN---EREVGAGIRckikegAVRREDLFIATK-----PPHP 73
Cdd:cd19074 7 LSLGTWLTFGGQVDdedakACVRKAYDLGINFFDTADVYAAgqaEEVLGKALK------GWPRESYVISTKvfwptGPGP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 74 -EW------IMSCSELS------------FClsHPRVQDLPLDEsnmvipsdtdfldTWEAMEDLVITGLVKNIGVSNFN 134
Cdd:cd19074 81 nDRglsrkhIFESIHASlkrlqldyvdiyYC--HRYDPETPLEE-------------TVRAMDDLIRQGKILYWGTSEWS 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 135 HEQLE---RLLNKPGLRfKPLTNQIECHpYLTQK---NLISFCQSRDVSVTAYRPLggsCEGV----------------- 191
Cdd:cd19074 146 AEQIAeahDLARQFGLI-PPVVEQPQYN-MLWREieeEVIPLCEKNGIGLVVWSPL---AQGLltgkyrdgipppsrsra 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462521296 192 ------DLIDNPV----------IKRIAKEHGKSPAQILIRFQIQRNVI--VIPGSITPSHIKENIQVFDFELTQ 248
Cdd:cd19074 221 tdednrDKKRRLLtdenlekvkkLKPIADELGLTLAQLALAWCLRNPAVssAIIGASRPEQLEENVKASGVKLSP 295
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
6-254 |
6.77e-12 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 64.77 E-value: 6.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 6 AVGLSSWKASPGKVTEAVK---EAIDAGYRHFDCAYFY-HNEREVGAGIrckiKEGAVRREDLFIATK------PP---- 71
Cdd:cd19144 20 AMGLSAFYGPPKPDEERFAvldAAFELGCTFWDTADIYgDSEELIGRWF----KQNPGKREKIFLATKfgieknVEtgey 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 72 ----HPEWIMSCSELSfclshprVQDLPLDESNMV----IPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERlln 143
Cdd:cd19144 96 svdgSPEYVKKACETS-------LKRLGVDYIDLYyqhrVDGKTPIEKTVAAMAELVQEGKIKHIGLSECSAETLRR--- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 144 kpGLRFKPLTN-QIECHPYLT-----QKNLISFCQSRDVSVTAYRPLG-GSCEG-------------------------- 190
Cdd:cd19144 166 --AHAVHPIAAvQIEYSPFSLdierpEIGVLDTCRELGVAIVAYSPLGrGFLTGairspddfeegdfrrmaprfqaenfp 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462521296 191 --VDLIDNpvIKRIAKEHGKSPAQILIRFQIQR--NVIVIPGSITPSHIKENIQVFDFELTQHDMDNI 254
Cdd:cd19144 244 knLELVDK--IKAIAKKKNVTAGQLTLAWLLAQgdDIIPIPGTTKLKRLEENLGALKVKLTEEEEKEI 309
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
3-256 |
1.87e-11 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 63.45 E-value: 1.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 3 DIPAVGLSSWKA----SPGKVTE-----AVKEAIDAGYRHFDCAYFY---HNEREVGAGIRCkikegavRREDLFIATKp 70
Cdd:cd19149 10 EASVIGLGTWAIgggpWWGGSDDnesirTIHAALDLGINLIDTAPAYgfgHSEEIVGKAIKG-------RRDKVVLATK- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 71 phpewimsCS------ELSF-----------CLSHPRVQDlPLDESNMVIpsDTDFLD---------------TWEAMED 118
Cdd:cd19149 82 --------CGlrwdreGGSFffvrdgvtvykNLSPESIRE-EVEQSLKRL--GTDYIDlyqthwqdvetpieeTMEALEE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 119 LVITGLVKNIGVSNFNHEQLERLLNKPGL-----RFKPLTNQIEchpyltqKNLISFCQSRDVSVTAYRPL--------- 184
Cdd:cd19149 151 LKRQGKIRAIGASNVSVEQIKEYVKAGQLdiiqeKYSMLDRGIE-------KELLPYCKKNNIAFQAYSPLeqglltgki 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 185 --------GGSCEG------------VDLIDNpvIKRIAKEHGKSPAQILIRFQIQR--NVIVIPGSITPSHIKENIQVF 242
Cdd:cd19149 224 tpdrefdaGDARSGipwfspenrekvLALLEK--WKPLCEKYGCTLAQLVIAWTLAQpgITSALCGARKPEQAEENAKAG 301
|
330
....*....|....
gi 2462521296 243 DFELTQHDMDNILS 256
Cdd:cd19149 302 DIRLSAEDIATMRS 315
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
21-240 |
3.94e-11 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 62.34 E-value: 3.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 21 EAVKEAIDAGYRHFDCA--YFY-HNEREVGAGIRCKIKEGAVRREDLFIATK----PP---------------------- 71
Cdd:cd19099 25 EALKAALDSGINVIDTAinYRGgRSERLIGKALRELIEKGGIKRDEVVIVTKagyiPGdgdeplrplkyleeklgrglid 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 72 -----------HPEWIMSCSELS----------FCLSH-PRVQDLPLDESNMvipsDTDFLDTWEAMEDLVITGLVKNIG 129
Cdd:cd19099 105 vadsaglrhciSPAYLEDQIERSlkrlgldtidLYLLHnPEEQLLELGEEEF----YDRLEEAFEALEEAVAEGKIRYYG 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 130 VSNFN----------HEQLERLL--------NKPGLRFKpltnQIECHPYLTQ------------KNLISFCQSRDVSVT 179
Cdd:cd19099 181 ISTWDgfrappalpgHLSLEKLVaaaeevggDNHHFKVI----QLPLNLLEPEaltekntvkgeaLSLLEAAKELGLGVI 256
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462521296 180 AYRPLGGsceGVDLIDNPVIKRIAKEHGKSPAQILIRFQIQRNVI--VIPGSITPSHIKENIQ 240
Cdd:cd19099 257 ASRPLNQ---GQLLGELRLADLLALPGGATLAQRALQFARSTPGVdsALVGMRRPEHVDENLA 316
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
20-254 |
6.99e-11 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 61.48 E-value: 6.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 20 TEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIrckikegAVRREDLFIATK--------PPH-------PEWIMSCSE 81
Cdd:cd19078 28 IELIRKAVELGITFFDTAEVYgpyTNEELVGEAL-------KPFRDQVVIATKfgfkidggKPGplgldsrPEHIRKAVE 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 82 LSfcLSHPRVQDLPLDESNMVIPsDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERllnkpGLRFKPLTN-QIECH- 159
Cdd:cd19078 101 GS--LKRLQTDYIDLYYQHRVDP-NVPIEEVAGTMKELIKEGKIRHWGLSEAGVETIRR-----AHAVCPVTAvQSEYSm 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 160 ----PyltQKNLISFCQSRDVSVTAYRPLGG-------------------------SCEGV----DLIDnpVIKRIAKEH 206
Cdd:cd19078 173 mwreP---EKEVLPTLEELGIGFVPFSPLGKgfltgkidentkfdegddraslprfTPEALeanqALVD--LLKEFAEEK 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 2462521296 207 GKSPAQILIRFQIQR--NVIVIPGSITPSHIKENIQVFDFELTQHDMDNI 254
Cdd:cd19078 248 GATPAQIALAWLLAKkpWIVPIPGTTKLSRLEENIGAADIELTPEELREI 297
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
8-239 |
7.97e-11 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 60.57 E-value: 7.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 8 GLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHN-EREVGAGIRckikeGavRREDLFIATKpphpewimscselsfcl 86
Cdd:cd19100 18 GGPLGRLSQEEAAAIIRRALDLGINYFDTAPSYGDsEEKIGKALK-----G--RRDKVFLATK----------------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 87 SHPRVQDLP---LDES--NMvipsDTDFLD---------------------TWEAMEDLVITGLVKNIGVSNFNHEQLER 140
Cdd:cd19100 74 TGARDYEGAkrdLERSlkRL----GTDYIDlyqlhavdteedldqvfgpggALEALLEAKEEGKIRFIGISGHSPEVLLR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 141 LLNKPG---LRFkPLtNQIECHPYLTQKNLISFCQSRDVSVTAYRPLGGScegvdlidnpvikRIAKEHGKSPAQiLIRF 217
Cdd:cd19100 150 ALETGEfdvVLF-PI-NPAGDHIDSFREELLPLAREKGVGVIAMKVLAGG-------------RLLSGDPLDPEQ-ALRY 213
|
250 260
....*....|....*....|....
gi 2462521296 218 QIQRNVI--VIPGSITPSHIKENI 239
Cdd:cd19100 214 ALSLPPVdvVIVGMDSPEELDENL 237
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
5-246 |
1.96e-10 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 59.88 E-value: 1.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 5 PAVGL--SSWKASPGKVT-----EAVKEAIDAGYRHFDCAYFYHN-EREVGAGIRckikegAVRREDLFIATK-PPHPEW 75
Cdd:cd19090 1 SALGLgtAGLGGVFGGVDddeavATIRAALDLGINYIDTAPAYGDsEERLGLALA------ELPREPLVLSTKvGRLPED 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 76 --------IMSCSELSF-CLSHPRVQDLPLDEsnmviPSDTDFLD------TWEAMEDLVITGLVKNIGVSNFNHEQLER 140
Cdd:cd19090 75 tadysadrVRRSVEESLeRLGRDRIDLLMIHD-----PERVPWVDilapggALEALLELKEEGLIKHIGLGGGPPDLLRR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 141 LLNkpglrfkplTNQIEC----HPY--LTQKN---LISFCQSRDVSVTAYRPLGG-----------SCEGVDLIDNPV-- 198
Cdd:cd19090 150 AIE---------TGDFDVvltaNRYtlLDQSAadeLLPAAARHGVGVINASPLGMgllagrppervRYTYRWLSPELLdr 220
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 2462521296 199 ---IKRIAKEHGKSPAQILIRF--QIQRNVIVIPGSITPSHIKENIQVFDFEL 246
Cdd:cd19090 221 akrLYELCDEHGVPLPALALRFllRDPRISTVLVGASSPEELEQNVAAAEGPL 273
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
24-257 |
3.78e-10 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 59.51 E-value: 3.78e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 24 KEAIDAGYRHFDCAYFY---HNEREVGAGIrckikegAVRREDLFIATK---PPHPE---------WIMSCSELS----- 83
Cdd:cd19087 37 DRALDAGINFFDTADVYgggRSEEIIGRWI-------AGRRDDIVLATKvfgPMGDDpndrglsrrHIRRAVEASlrrlq 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 84 ------FCLSHPRVqDLPLDEsnmvipsdtdfldTWEAMEDLVITGLVKNIGVSNFNHEQLERLLN---KPGL-RF---K 150
Cdd:cd19087 110 tdyidlYQMHHFDR-DTPLEE-------------TLRALDDLVRQGKIRYIGVSNFAAWQIAKAQGiaaRRGLlRFvseQ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 151 PLTN----QIECHpyltqknLISFCQSRDVSVTAYRPLGG--------------SCEGVDLIDN----------PVIKR- 201
Cdd:cd19087 176 PMYNllkrQAELE-------ILPAARAYGLGVIPYSPLAGglltgkygkgkrpeSGRLVERARYqarygleeyrDIAERf 248
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 202 --IAKEHGKSPAQILIRFQIQRNVI--VIPGSITPSHIKENIQVFDFELTQHDMDNILSL 257
Cdd:cd19087 249 eaLAAEAGLTPASLALAWVLSHPAVtsPIIGPRTLEQLEDSLAALEITLTPELLAEIDEL 308
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
15-257 |
7.20e-10 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 58.50 E-value: 7.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 15 SPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegAVRREDLFIATKpphpewimscselsFClshPRV 91
Cdd:cd19103 30 DEDTLKAVFDKAMAAGLNLWDTAAVYgmgASEKILGEFLK------RYPREDYIISTK--------------FT---PQI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 92 QDlplDESNMVIPS--------DTDFLDT-W-----------EAMEDLVITGLVKNIGVSNFNHEQLER---LLNKPGLR 148
Cdd:cd19103 87 AG---QSADPVADMlegslarlGTDYIDIyWihnpadverwtPELIPLLKSGKVKHVGVSNHNLAEIKRaneILAKAGVS 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 149 FKPLTNqiecHPYLTQKN-----LISFCQSRDVSVTAY---------------RPL-GGSCEGVDLID--------NPVI 199
Cdd:cd19103 164 LSAVQN----HYSLLYRSseeagILDYCKENGITFFAYmvleqgalsgkydtkHPLpEGSGRAETYNPllpqleelTAVM 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 2462521296 200 KRIAKEHGKSPAQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSL 257
Cdd:cd19103 240 AEIGAKHGASIAQVAIAWAIAKGTTPIIGVTKPHHVEDAARAASITLTDDEIKELEQL 297
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
3-254 |
8.73e-10 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 58.09 E-value: 8.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 3 DIPA--VGLSSWK--------ASPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIrckikEGAVRREDLFIATK 69
Cdd:cd19148 1 DLPVsrIALGTWAiggwmwggTDEKEAIETIHKALDLGINLIDTAPVYgfgLSEEIVGKAL-----KEYGKRDRVVIATK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 70 -------------PPHPEWIMScsELSFCLShpRVQDLPLDESNMVIPSD-TDFLDTWEAMEDLVITGLVKNIGVSNFNH 135
Cdd:cd19148 76 vglewdeggevvrNSSPARIRK--EVEDSLR--RLQTDYIDLYQVHWPDPlVPIEETAEALKELLDEGKIRAIGVSNFSP 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 136 EQLERLlnkpgLRFKPL-TNQIechPY-----LTQKNLISFCQSRDVSVTAYRPLggsCEGV--------------DLID 195
Cdd:cd19148 152 EQMETF-----RKVAPLhTVQP---PYnlferEIEKDVLPYARKHNIVTLAYGAL---CRGLlsgkmtkdtkfegdDLRR 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462521296 196 N-PV---------------IKRIAKEH-GKSPAQILIRFQIQRNVIVIP--GSITPSHIKENIQVFDFELTQHDMDNI 254
Cdd:cd19148 221 TdPKfqeprfsqylaaveeLDKLAQERyGKSVIHLAVRWLLDQPGVSIAlwGARKPEQLDAVDEVFGWSLNDEDMKEI 298
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
106-240 |
1.11e-09 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 57.73 E-value: 1.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 106 DTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLER----------------------LLNKPGLRFKpltNQIechpyLT 163
Cdd:cd19752 124 DTPLEETLEAFNELVKAGKVRAIGASNFAAWRLERarqiarqqgwaefsaiqqrhsyLRPRPGADFG---VQR-----IV 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 164 QKNLISFCQSR-DVSVTAYRPLGGSCEGVDliDNP---------------VIKRIAKEHGKSPAQILIRFQIQRNVIVIP 227
Cdd:cd19752 196 TDELLDYASSRpDLTLLAYSPLLSGAYTRP--DRPlpeqydgpdsdarlaVLEEVAGELGATPNQVVLAWLLHRTPAIIP 273
|
170
....*....|....*
gi 2462521296 228 --GSITPSHIKENIQ 240
Cdd:cd19752 274 llGASTVEQLEENLA 288
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
107-254 |
1.75e-08 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 54.49 E-value: 1.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 107 TDFLDTWEAMEDLVITGLVKNIGVSN--------FNHeqLERLLNKPglrfKPLTNQiecHPY--LTQKNLISF---CQS 173
Cdd:cd19094 144 VSFEEQLEALGELVKAGKIRHIGLSNetpwgvmkFLE--LAEQLGLP----RIVSIQ---NPYslLNRNFEEGLaeaCHR 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 174 RDVSVTAYRPLGGsceGV------DLIDNPVIKR-------------------------IAKEHGKSPAQILIRFQIQRN 222
Cdd:cd19094 215 ENVGLLAYSPLAG---GVltgkylDGAARPEGGRlnlfpgymaryrspqaleavaeyvkLARKHGLSPAQLALAWVRSRP 291
|
170 180 190
....*....|....*....|....*....|....
gi 2462521296 223 VI--VIPGSITPSHIKENIQVFDFELTQHDMDNI 254
Cdd:cd19094 292 FVtsTIIGATTLEQLKENIDAFDVPLSDELLAEI 325
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
17-243 |
5.42e-08 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 52.53 E-value: 5.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 17 GKVTEA-----VKEAIDAGYRHFDCAYFYHN-EREVGagirckikEGAVRREDLFIATKPPH--------PEWIM----- 77
Cdd:cd19097 21 GKPSEKeakkiLEYALKAGINTLDTAPAYGDsEKVLG--------KFLKRLDKFKIITKLPPlkedkkedEAAIEasvea 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 78 SCSEL-----SFCLSHpRVQDLPLDESNMvipsdtdfldtWEAMEDLVITGLVKNIGVSNFNHEQLERLLNkpglRFKPL 152
Cdd:cd19097 93 SLKRLkvdslDGLLLH-NPDDLLKHGGKL-----------VEALLELKKEGLIRKIGVSVYSPEELEKALE----SFKID 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 153 TNQIECHPY---LTQKNLISFCQSRDVSV-------------TAYRPLGGSCEGVDLIDNpvIKRIAKEHGKSPAQILIR 216
Cdd:cd19097 157 IIQLPFNILdqrFLKSGLLAKLKKKGIEIharsvflqglllmEPDKLPAKFAPAKPLLKK--LHELAKKLGLSPLELALG 234
|
250 260
....*....|....*....|....*....
gi 2462521296 217 FQIQRNVI--VIPGSITPSHIKENIQVFD 243
Cdd:cd19097 235 FVLSLPEIdkIVVGVDSLEQLKEIIAAFK 263
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
27-243 |
8.63e-08 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 52.17 E-value: 8.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 27 IDAGYRHFDCAYFY-------HNEREVGAGIRCKIKegavrREDLFIATKPPHP-EWIMSCSELS-FCLSHprvqDLplD 97
Cdd:cd19082 27 VELGGNFIDTARVYgdwvergASERVIGEWLKSRGN-----RDKVVIATKGGHPdLEDMSRSRLSpEDIRA----DL--E 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 98 ES--NMvipsDTDFLDTW---------------EAMEDLVITGLVKNIGVSNFNHEQLE---RLLNKPGLRfkPLT-NQI 156
Cdd:cd19082 96 ESleRL----GTDYIDLYflhrddpsvpvgeivDTLNELVRAGKIRAFGASNWSTERIAeanAYAKAHGLP--GFAaSSP 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 157 ---------ECHPYLT----QKNLISFCQSRDVSVTAYRPLGG-------------SCEGVDLIDNPV-------IKRIA 203
Cdd:cd19082 170 qwslarpnePPWPGPTlvamDEEMRAWHEENQLPVFAYSSQARgffskraaggaedDSELRRVYYSEEnferlerAKELA 249
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 2462521296 204 KEHGKSPAQILIRFQIQR--NVIVIPGSITPSHIKENIQVFD 243
Cdd:cd19082 250 EEKGVSPTQIALAYVLNQpfPTVPIIGPRTPEQLRDSLAAAD 291
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
27-247 |
6.90e-07 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 49.53 E-value: 6.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 27 IDAGYRHFDCAYFYHN---EREVGAGIrckikegAVRREDLFIATK------PPHPewimscselSFCLSHPRvqdlpld 97
Cdd:cd19080 41 VEAGGNFIDTANNYTNgtsERLLGEFI-------AGNRDRIVLATKytmnrrPGDP---------NAGGNHRK------- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 98 esNMVIPSD-------TDFLD-----TWE----------AMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLR-FKPLTN 154
Cdd:cd19080 98 --NLRRSVEaslrrlqTDYIDllyvhAWDfttpveevmrALDDLVRAGKVLYVGISDTPAWVVARANTLAELRgWSPFVA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 155 -QIECHpyLTQKN----LISFCQSRDVSVTAYRPLGG-----------SCEGVDLIDNP---------------VIKRIA 203
Cdd:cd19080 176 lQIEYS--LLERTpereLLPMARALGLGVTPWSPLGGglltgkyqrgeEGRAGEAKGVTvgfgklternwaivdVVAAVA 253
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2462521296 204 KEHGKSPAQILIRFQIQRNVIVIP--GSITPSHIKENIQVFDFELT 247
Cdd:cd19080 254 EELGRSAAQVALAWVRQKPGVVIPiiGARTLEQLKDNLGALDLTLS 299
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
4-243 |
1.23e-06 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 48.79 E-value: 1.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 4 IPAVGLSSWK-----ASPGKVTEAVKEAIDAGYRHFDCAYFY-----HNEREVGAGIRckiKEGAVRREDLFIATK---- 69
Cdd:cd19089 11 LPAISLGLWHnfgdyTSPEEARELLRTAFDLGITHFDLANNYgpppgSAEENFGRILK---RDLRPYRDELVISTKagyg 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 70 ---PPHPEW-----IMSCSELSF----------CLSHPRVQDLPLDEsnmvipsdtdfldTWEAMEDLVITGLVKNIGVS 131
Cdd:cd19089 88 mwpGPYGDGgsrkyLLASLDQSLkrmgldyvdiFYHHRYDPDTPLEE-------------TMTALADAVRSGKALYVGIS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 132 NFNHEQLER---LLNKPGLRFkpLTNQIechPY--LTQ---KNLISFCQSRDVSVTAYRPLGG----------------- 186
Cdd:cd19089 155 NYPGAKARRaiaLLRELGVPL--IIHQP---RYslLDRwaeDGLLEVLEEAGIGFIAFSPLAQglltdkylngippdsrr 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462521296 187 SCEGVDLID-------NPVIK---RIAKEHGKSPAQILIRFQIQRNVI--VIPGSITPSHIKENIQVFD 243
Cdd:cd19089 230 AAESKFLTEealtpekLEQLRklnKIAAKRGQSLAQLALSWVLRDPRVtsVLIGASSPSQLEDNVAALK 298
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
22-240 |
1.62e-06 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 48.42 E-value: 1.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 22 AVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegaVRREDLFIATK----PPHPEWIMSCSELS----------- 83
Cdd:cd19104 37 AVRRALDLGINFFDTAPSYgdgKSEENLGRALK-------GLPAGPYITTKvrldPDDLGDIGGQIERSvekslkrlkrd 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 84 -----FCLSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLER----------------LL 142
Cdd:cd19104 110 svdllQLHNRIGDERDKPVGGTLSTTDVLGLGGVADAFERLRSEGKIRFIGITGLGNPPAIRelldsgkfdavqvyynLL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 143 NKPGLRFKPltnqiECHPYLTQKNLISFCQSRDVSVTAYRPL--GGSCEGVDLIDNPVI----------------KRIAK 204
Cdd:cd19104 190 NPSAAEARP-----RGWSAQDYGGIIDAAAEHGVGVMGIRVLaaGALTTSLDRGREAPPtsdsdvaidfrraaafRALAR 264
|
250 260 270
....*....|....*....|....*....|....*...
gi 2462521296 205 EHGKSPAQILIRFQIQRNVI--VIPGSITPSHIKENIQ 240
Cdd:cd19104 265 EWGETLAQLAHRFALSNPGVstVLVGVKNREELEEAVA 302
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
7-245 |
3.03e-05 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 44.52 E-value: 3.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 7 VGLSSW-----KASPGKVTEAVKEAIDAGYRHFDCAYFYHN---EREVGAGIRckikegAVRREDLFIATK--------- 69
Cdd:cd19152 5 FGTAPLgnlyeAVSDEEAKATLVAAWDLGIRYFDTAPWYGAglsEERLGAALR------ELGREDYVISTKvgrllvplq 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 70 -------------PPH-PEW------IMSCSELSFC-LSHPRVQ-----DLpldESNMVIPSDTDFLDTW-----EAMED 118
Cdd:cd19152 79 eveptfepgfwnpLPFdAVFdysydgILRSIEDSLQrLGLSRIDllsihDP---DEDLAGAESDEHFAQAikgafRALEE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 119 LVITGLVKNIGV-SNFnHEQLERLLNKPGL-------RFKPLTnqiecHPYLTqkNLISFCQSRDVSVTAYRPL------ 184
Cdd:cd19152 156 LREEGVIKAIGLgVND-WEVILRILEEADLdwvmlagRYTLLD-----HSAAR--ELLPECEKRGVKVVNAGPFnsgfla 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462521296 185 GGSCEGVDlIDNPV----------IKRIAKEHGKSPAQILIRFQIQRNVI--VIPGSITPSHIKENIQVFDFE 245
Cdd:cd19152 228 GGDNFDYY-EYGPAppeliarrdrIEALCEQHGVSLAAAALQFALAPPAVasVAPGASSPERVEENVALLATE 299
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
18-142 |
2.12e-04 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 41.88 E-value: 2.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 18 KVTEAVKEAIDAGYRHFDCAYFYHnEREVGAGIRCKIKEGAVRREDLFIATKPPH---------PEWImscsELSFCLSH 88
Cdd:cd19164 35 PPVDIVRRALELGIRAFDTSPYYG-PSEIILGRALKALRDEFPRDTYFIITKVGRygpddfdysPEWI----RASVERSL 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 89 PRVQDLPLDesnMVIPSDTDFL---DTWEAMEDLV---ITGLVKNIGVSNFnheQLERLL 142
Cdd:cd19164 110 RRLHTDYLD---LVYLHDVEFVadeEVLEALKELFklkDEGKIRNVGISGY---PLPVLL 163
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
6-243 |
1.14e-03 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 39.83 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 6 AVGLSSWKASPGKVTEA---VKEAIDAGYRHFDCAYFYHN---EREVGAGIRckikEGAVRREDLFIATKPPH---PEWI 76
Cdd:cd19153 19 TAALGGVYGDGLEQDEAvaiVAEAFAAGINHFDTSPYYGAessEAVLGKALA----ALQVPRSSYTVATKVGRyrdSEFD 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 77 MSCSELSFCL--SHPRVQDLPLDesnMVIPSDTDFLD-------TWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGL 147
Cdd:cd19153 95 YSAERVRASVatSLERLHTTYLD---VVYLHDIEFVDydtlvdeALPALRTLKDEGVIKRIGIAGYPLDTLTRATRRCSP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462521296 148 RfKPLTNQIECH------------PYLTQKNLISFCQSRDVSVTAYRPLGGS----CEGVDLIDNPVIKRIAKEHGKSPA 211
Cdd:cd19153 172 G-SLDAVLSYCHltlqdarlesdaPGLVRGAGPHVINASPLSMGLLTSQGPPpwhpASGELRHYAAAADAVCASVEASLP 250
|
250 260 270
....*....|....*....|....*....|....*
gi 2462521296 212 QILIRFQIQRNVIVIP---GSITPSHIKENIQVFD 243
Cdd:cd19153 251 DLALQYSLAAHAGVGTvllGPSSLAQLRSMLAAVD 285
|
|
| |
