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Conserved domains on  [gi|2462520640|ref|XP_054222547|]
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lipase member K isoform X3 [Homo sapiens]

Protein Classification

lipase family protein( domain architecture ID 706631)

lipase family protein that may function as a lipase, catalyzing the hydrolysis of ester bonds of insoluble substrates such a triglycerides

EC:  3.1.1.-
Gene Ontology:  GO:0016298|GO:0016788|GO:0006629

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PLN02872 super family cl28691
triacylglycerol lipase
31-386 2.05e-52

triacylglycerol lipase


The actual alignment was detected with superfamily member PLN02872:

Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 179.68  E-value: 2.05e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640  31 MLLLGSMYGYDKKGNNANPEANMNI--------SQIISYWGYPYEEYDVTTKDGYILGIYRIPhGRGCPGRTAPKPAVYL 102
Cdd:PLN02872    1 VAVLISLFISTSAGGVLTGQSNLLRrspveslcAQLIHPAGYSCTEHTIQTKDGYLLALQRVS-SRNPRLGSQRGPPVLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640 103 QHGLIASASNWICNLPNNSLAFLLADSGYDVWLGNSRGNTWSRKHLKLSPKSPEYWAFSLDEMAKYDLPATINFIIEKTG 182
Cdd:PLN02872   80 QHGLFMAGDAWFLNSPEQSLGFILADHGFDVWVGNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSITN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640 183 QKrLYYVGHSQGTTIAFIAFsTNPELAKKIKIFFALAPVVTVKYTQSP----MKKLtTLSRRVVKVLFGDKMFHPHTLFD 258
Cdd:PLN02872  160 SK-IFIVGHSQGTIMSLAAL-TQPNVVEMVEAAALLCPISYLDHVTAPlvlrMVFM-HLDQMVVAMGIHQLNFRSDVLVK 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640 259 qfIATKVCNRKLfrrICSNFLFTLSGfdpQN--LNMSRLDVYLSHNPAGTSVQNMLH----------------------- 313
Cdd:PLN02872  237 --LLDSICEGHM---DCNDLLTSITG---TNccFNASRIDYYLEYEPHPSSVKNLRHlfqmirkgtfahydygifknlkl 308
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462520640 314 WAQLTPPLYNITKMEVPTAIW--NGGQDIVADPKDVENL---LPQIANLIYyklIPHYNHVDFYLGEDAPQEIYQDLI 386
Cdd:PLN02872  309 YGQVNPPAFDLSLIPKSLPLWmgYGGTDGLADVTDVEHTlaeLPSKPELLY---LENYGHIDFLLSTSAKEDVYNHMI 383
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
31-386 2.05e-52

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 179.68  E-value: 2.05e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640  31 MLLLGSMYGYDKKGNNANPEANMNI--------SQIISYWGYPYEEYDVTTKDGYILGIYRIPhGRGCPGRTAPKPAVYL 102
Cdd:PLN02872    1 VAVLISLFISTSAGGVLTGQSNLLRrspveslcAQLIHPAGYSCTEHTIQTKDGYLLALQRVS-SRNPRLGSQRGPPVLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640 103 QHGLIASASNWICNLPNNSLAFLLADSGYDVWLGNSRGNTWSRKHLKLSPKSPEYWAFSLDEMAKYDLPATINFIIEKTG 182
Cdd:PLN02872   80 QHGLFMAGDAWFLNSPEQSLGFILADHGFDVWVGNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSITN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640 183 QKrLYYVGHSQGTTIAFIAFsTNPELAKKIKIFFALAPVVTVKYTQSP----MKKLtTLSRRVVKVLFGDKMFHPHTLFD 258
Cdd:PLN02872  160 SK-IFIVGHSQGTIMSLAAL-TQPNVVEMVEAAALLCPISYLDHVTAPlvlrMVFM-HLDQMVVAMGIHQLNFRSDVLVK 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640 259 qfIATKVCNRKLfrrICSNFLFTLSGfdpQN--LNMSRLDVYLSHNPAGTSVQNMLH----------------------- 313
Cdd:PLN02872  237 --LLDSICEGHM---DCNDLLTSITG---TNccFNASRIDYYLEYEPHPSSVKNLRHlfqmirkgtfahydygifknlkl 308
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462520640 314 WAQLTPPLYNITKMEVPTAIW--NGGQDIVADPKDVENL---LPQIANLIYyklIPHYNHVDFYLGEDAPQEIYQDLI 386
Cdd:PLN02872  309 YGQVNPPAFDLSLIPKSLPLWmgYGGTDGLADVTDVEHTlaeLPSKPELLY---LENYGHIDFLLSTSAKEDVYNHMI 383
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
55-117 2.31e-31

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 113.40  E-value: 2.31e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462520640  55 ISQIISYWGYPYEEYDVTTKDGYILGIYRIPHGRGCPGRTAPKPAVYLQHGLIASASNWICNL 117
Cdd:pfam04083   1 VSEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRNNSNGKGGKPVVLLQHGLLASSDNWVTNG 63
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
67-212 9.74e-08

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 52.31  E-value: 9.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640  67 EEYDVTTKDGYILgiyripHGRGCPGRTAPKPAVYLQHGLIASASNWicnlpnNSLAFLLADSGYDVWLGNSRGntwsrk 146
Cdd:COG2267     4 RLVTLPTRDGLRL------RGRRWRPAGSPRGTVVLVHGLGEHSGRY------AELAEALAAAGYAVLAFDLRG------ 65
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462520640 147 HlKLSPKSPEYWAfSLDEMAKyDLPATINFIIEKTGQkRLYYVGHSQGTTIAFIAFSTNPELAKKI 212
Cdd:COG2267    66 H-GRSDGPRGHVD-SFDDYVD-DLRAALDALRARPGL-PVVLLGHSMGGLIALLYAARYPDRVAGL 127
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
31-386 2.05e-52

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 179.68  E-value: 2.05e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640  31 MLLLGSMYGYDKKGNNANPEANMNI--------SQIISYWGYPYEEYDVTTKDGYILGIYRIPhGRGCPGRTAPKPAVYL 102
Cdd:PLN02872    1 VAVLISLFISTSAGGVLTGQSNLLRrspveslcAQLIHPAGYSCTEHTIQTKDGYLLALQRVS-SRNPRLGSQRGPPVLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640 103 QHGLIASASNWICNLPNNSLAFLLADSGYDVWLGNSRGNTWSRKHLKLSPKSPEYWAFSLDEMAKYDLPATINFIIEKTG 182
Cdd:PLN02872   80 QHGLFMAGDAWFLNSPEQSLGFILADHGFDVWVGNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSITN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640 183 QKrLYYVGHSQGTTIAFIAFsTNPELAKKIKIFFALAPVVTVKYTQSP----MKKLtTLSRRVVKVLFGDKMFHPHTLFD 258
Cdd:PLN02872  160 SK-IFIVGHSQGTIMSLAAL-TQPNVVEMVEAAALLCPISYLDHVTAPlvlrMVFM-HLDQMVVAMGIHQLNFRSDVLVK 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640 259 qfIATKVCNRKLfrrICSNFLFTLSGfdpQN--LNMSRLDVYLSHNPAGTSVQNMLH----------------------- 313
Cdd:PLN02872  237 --LLDSICEGHM---DCNDLLTSITG---TNccFNASRIDYYLEYEPHPSSVKNLRHlfqmirkgtfahydygifknlkl 308
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462520640 314 WAQLTPPLYNITKMEVPTAIW--NGGQDIVADPKDVENL---LPQIANLIYyklIPHYNHVDFYLGEDAPQEIYQDLI 386
Cdd:PLN02872  309 YGQVNPPAFDLSLIPKSLPLWmgYGGTDGLADVTDVEHTlaeLPSKPELLY---LENYGHIDFLLSTSAKEDVYNHMI 383
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
55-117 2.31e-31

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 113.40  E-value: 2.31e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462520640  55 ISQIISYWGYPYEEYDVTTKDGYILGIYRIPHGRGCPGRTAPKPAVYLQHGLIASASNWICNL 117
Cdd:pfam04083   1 VSEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRNNSNGKGGKPVVLLQHGLLASSDNWVTNG 63
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
98-374 2.98e-26

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 105.66  E-value: 2.98e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640  98 PAVYLQHGLIASASNWICNLPNnslaflLADSGYDVWLGNSRGNTWSRKHLKLSpkspeywAFSLDEMAKYdlpatINFI 177
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPA------LARDGFRVIALDLRGFGKSSRPKAQD-------DYRTDDLAED-----LEYI 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640 178 IEKTGQKRLYYVGHSQGTTIAFIAFSTNPELAKKikiffalapVVTVKyTQSPMKKLTTLSRRVVKVLFGdkmfhphtLF 257
Cdd:pfam00561  63 LEALGLEKVNLVGHSMGGLIALAYAAKYPDRVKA---------LVLLG-ALDPPHELDEADRFILALFPG--------FF 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640 258 DQFIAtkVCNRKLFRRICSNFLFTLSGFD-------PQNLNMSRLDVYLSHNPAGTSVQNMLHWAQlTPPLYNITKMEVP 330
Cdd:pfam00561 125 DGFVA--DFAPNPLGRLVAKLLALLLLRLrllkalpLLNKRFPSGDYALAKSLVTGALLFIETWST-ELRAKFLGRLDEP 201
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 2462520640 331 TAIWNGGQDIVADPKDVENlLPQIANLIYYKLIPHYNHVDFYLG 374
Cdd:pfam00561 202 TLIIWGDQDPLVPPQALEK-LAQLFPNARLVVIPDAGHFAFLEG 244
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
67-212 9.74e-08

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 52.31  E-value: 9.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640  67 EEYDVTTKDGYILgiyripHGRGCPGRTAPKPAVYLQHGLIASASNWicnlpnNSLAFLLADSGYDVWLGNSRGntwsrk 146
Cdd:COG2267     4 RLVTLPTRDGLRL------RGRRWRPAGSPRGTVVLVHGLGEHSGRY------AELAEALAAAGYAVLAFDLRG------ 65
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462520640 147 HlKLSPKSPEYWAfSLDEMAKyDLPATINFIIEKTGQkRLYYVGHSQGTTIAFIAFSTNPELAKKI 212
Cdd:COG2267    66 H-GRSDGPRGHVD-SFDDYVD-DLRAALDALRARPGL-PVVLLGHSMGGLIALLYAARYPDRVAGL 127
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
65-217 1.11e-06

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 49.88  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640  65 PYEEYDVTTKDGYILgiyripHGRGCPGRTAPKPAVYLQHGLIASASNWicnlpnNSLAFLLADSGYDVWLGNSRGNTWS 144
Cdd:COG4757     6 SPESVTITAADGYPL------AARLFPPAGPPRAVVLINPATGVPQRFY------RPFARYLAERGFAVLTYDYRGIGLS 73
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462520640 145 RkhlklsPKSPEYWAFSLDEMAKYDLPATINFIIEKTGQKRLYYVGHSQGTTIafIAFSTNPELAKKIkIFFA 217
Cdd:COG4757    74 R------PGSLRGFDAGYRDWGELDLPAVLDALRARFPGLPLLLVGHSLGGQL--LGLAPNAERVDRL-VTVA 137
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
94-198 4.59e-06

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 44.82  E-value: 4.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640  94 TAPKPAVYLQHGLIASASNWicnlpnNSLAFLLADSGYDVWlgnsrgntwsrkhlklspkSPEYWAF--SLDEMAKYdLP 171
Cdd:COG1075     2 AATRYPVVLVHGLGGSAASW------APLAPRLRAAGYPVY-------------------ALNYPSTngSIEDSAEQ-LA 55
                          90       100
                  ....*....|....*....|....*..
gi 2462520640 172 ATINFIIEKTGQKRLYYVGHSQGTTIA 198
Cdd:COG1075    56 AFVDAVLAATGAEKVDLVGHSMGGLVA 82
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
94-361 2.37e-04

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 42.20  E-value: 2.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640  94 TAPKPAVYLQHGLiASASNWICNLpnnslAFLLADSGYDVWLGNSRGntwsrkHLKlSPKSPEYWAfSLDEMAKyDLPAT 173
Cdd:pfam12146   1 GEPRAVVVLVHGL-GEHSGRYAHL-----ADALAAQGFAVYAYDHRG------HGR-SDGKRGHVP-SFDDYVD-DLDTF 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640 174 INFIIEKTGQKRLYYVGHSQGTTIAFIAFSTNPELAKKIkIFFALApvvtVKYTQSPMKKLTTLSRRVVKVLFGDKMFHP 253
Cdd:pfam12146  66 VDKIREEHPGLPLFLLGHSMGGLIAALYALRYPDKVDGL-ILSAPA----LKIKPYLAPPILKLLAKLLGKLFPRLRVPN 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640 254 HTLFDqfiatKVCNRKLFRRICSNflftlsgfDPQNLNMSRLDVYLShnpagtSVQNMlhwAQLTPPLYNITkmeVPTAI 333
Cdd:pfam12146 141 NLLPD-----SLSRDPEVVAAYAA--------DPLVHGGISARTLYE------LLDAG---ERLLRRAAAIT---VPLLL 195
                         250       260       270
                  ....*....|....*....|....*....|..
gi 2462520640 334 WNGGQDIVADPKD----VENLLPQIANLIYYK 361
Cdd:pfam12146 196 LHGGADRVVDPAGsrefYERAGSTDKTLKLYP 227
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
71-210 3.02e-03

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 38.84  E-value: 3.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462520640  71 VTTKDGYIL-GIYRIPHGRGcpgrtaPKPAVYLQHGLIASASNWicnlpNNSLAFLLADSGYDVWLGNSRGNTWSRKHlk 149
Cdd:COG1506     2 FKSADGTTLpGWLYLPADGK------KYPVVVYVHGGPGSRDDS-----FLPLAQALASRGYAVLAPDYRGYGESAGD-- 68
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462520640 150 lspkspeywaFSLDEMAkyDLPATINFIIEKTG--QKRLYYVGHSQGTTIAFIAFSTNPELAK 210
Cdd:COG1506    69 ----------WGGDEVD--DVLAAIDYLAARPYvdPDRIGIYGHSYGGYMALLAAARHPDRFK 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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