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Conserved domains on  [gi|2462518349|ref|XP_054221430|]
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attractin-like protein 1 isoform X8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CLECT_attractin_like cd03597
C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and ...
 321-447 1.80e-81

C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP); CLECT_attractin_like: C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP). CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. Mouse AtrN (the product of the mahogany gene) has been shown to bind Agouti protein and to function in agouti-induced pigmentation and obesity. Mutations in AtrN have also been shown to cause spongiform encephalopathy and hypomyelination in rats and hamsters. The cytoplasmic region of mouse ALP has been shown to binds to melanocortin receptor (MCR4). Signaling through MCR4 plays a role in appetite suppression. Attractin may have therapeutic potential in the treatment of obesity. Human attractin (hAtrN) has been shown to be expressed on activated T cells and released extracellularly. The circulating serum attractin induces the spreading of monocytes that become the focus of the clustering of non-proliferating T cells.


:

Pssm-ID: 153067  Cd Length: 129  Bit Score: 259.05  E-value: 1.80e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349 321 CGEGWSHIGDACLRVNSSRENYDNAKLYCYNLSGNLASLTTSKEVEFVLDEIQK--YTQQKVSPWVGLRKINISYWGWED 398
Cdd:cd03597     1 CGEGWHLVGNSCLKINTARESYDNAKLYCRNLNAVLASLTTQKKVEFVLKELQKhqMTKQKLTPWVGLRKINVSYWCWED 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2462518349 399 MSPFTNTTLQWLPGEPNDSGFCAYLERAAVAGLKANPCTSMANGLVCEK 447
Cdd:cd03597    81 MSPFTNTTLQWLPGEPSDAGFCGYLEEPAVSGLKANPCTNPVNGSVCER 129
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
54-185 5.37e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 76.35  E-value: 5.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349  54 IYVHGGYKALpgnkyGLVDDLYKYEVNTKTWTILKE-SGFARYLHSAVLINGAMLIFGGNTHNDTSLSngakcFSADFLA 132
Cdd:COG3055    25 VYVAGGLSGG-----SASNSFEVYDPATNTWSELAPlPGPPRHHAAAVAQDGKLYVFGGFTGANPSST-----PLNDVYV 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462518349 133 YDIACDEW-KILPKPnlhrdVNRFGHSAVVINGSMYIFGGFS-SVLLNDILVYKP 185
Cdd:COG3055    95 YDPATNTWtKLAPMP-----TPRGGATALLLDGKIYVVGGWDdGGNVAWVEVYDP 144
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 586-631 2.11e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.42  E-value: 2.11e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462518349 586 ACQCNGHSTciNNNVCEQ------CKNLTTGKQCQDCMPGYYGDPTNGGQCT 631
Cdd:cd00055     1 PCDCNGHGS--LSGQCDPgtgqceCKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 462-511 5.48e-06

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 44.24  E-value: 5.48e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462518349 462 PCSLRTSCSNCT-SNGMECMWCSSTKRCVDSNAYiiSFPYGQCLEWQTATC 511
Cdd:pfam01437   1 RCSQYTSCSSCLaARDPYCGWCSSEGRCVRRSAC--GAPEGNCEEWEQASS 49
 
Name Accession Description Interval E-value
CLECT_attractin_like cd03597
C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and ...
 321-447 1.80e-81

C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP); CLECT_attractin_like: C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP). CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. Mouse AtrN (the product of the mahogany gene) has been shown to bind Agouti protein and to function in agouti-induced pigmentation and obesity. Mutations in AtrN have also been shown to cause spongiform encephalopathy and hypomyelination in rats and hamsters. The cytoplasmic region of mouse ALP has been shown to binds to melanocortin receptor (MCR4). Signaling through MCR4 plays a role in appetite suppression. Attractin may have therapeutic potential in the treatment of obesity. Human attractin (hAtrN) has been shown to be expressed on activated T cells and released extracellularly. The circulating serum attractin induces the spreading of monocytes that become the focus of the clustering of non-proliferating T cells.


Pssm-ID: 153067  Cd Length: 129  Bit Score: 259.05  E-value: 1.80e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349 321 CGEGWSHIGDACLRVNSSRENYDNAKLYCYNLSGNLASLTTSKEVEFVLDEIQK--YTQQKVSPWVGLRKINISYWGWED 398
Cdd:cd03597     1 CGEGWHLVGNSCLKINTARESYDNAKLYCRNLNAVLASLTTQKKVEFVLKELQKhqMTKQKLTPWVGLRKINVSYWCWED 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2462518349 399 MSPFTNTTLQWLPGEPNDSGFCAYLERAAVAGLKANPCTSMANGLVCEK 447
Cdd:cd03597    81 MSPFTNTTLQWLPGEPSDAGFCGYLEEPAVSGLKANPCTNPVNGSVCER 129
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
54-185 5.37e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 76.35  E-value: 5.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349  54 IYVHGGYKALpgnkyGLVDDLYKYEVNTKTWTILKE-SGFARYLHSAVLINGAMLIFGGNTHNDTSLSngakcFSADFLA 132
Cdd:COG3055    25 VYVAGGLSGG-----SASNSFEVYDPATNTWSELAPlPGPPRHHAAAVAQDGKLYVFGGFTGANPSST-----PLNDVYV 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462518349 133 YDIACDEW-KILPKPnlhrdVNRFGHSAVVINGSMYIFGGFS-SVLLNDILVYKP 185
Cdd:COG3055    95 YDPATNTWtKLAPMP-----TPRGGATALLLDGKIYVVGGWDdGGNVAWVEVYDP 144
Lectin_C pfam00059
Lectin C-type domain; This family includes both long and short form C-type
 339-447 6.00e-15

Lectin C-type domain; This family includes both long and short form C-type


Pssm-ID: 459655 [Multi-domain]  Cd Length: 105  Bit Score: 71.35  E-value: 6.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349 339 RENYDNAKLYCYNLSGNLASLTTSKEVEFVLDEIQKYtqqKVSPWVGLRKINIS-YWGWEDMSPFTNTTLQWLPGEPNDS 417
Cdd:pfam00059   1 SKTWDEAREACRKLGGHLVSINSAEELDFLSSTLKKS---NKYFWIGLTDRKNEgTWKWVDGSPVNYTNWAPEPNNNGEN 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462518349 418 GFCAYLERAAvAGLKANPCTSMaNGLVCEK 447
Cdd:pfam00059  78 EDCVELSSSS-GKWNDENCNSK-NPFVCEK 105
CLECT smart00034
C-type lectin (CTL) or carbohydrate-recognition domain (CRD); Many of these domains function ...
 321-446 3.11e-14

C-type lectin (CTL) or carbohydrate-recognition domain (CRD); Many of these domains function as calcium-dependent carbohydrate binding modules.


Pssm-ID: 214480 [Multi-domain]  Cd Length: 124  Bit Score: 70.32  E-value: 3.11e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349  321 CGEGWSHIGDACLRVNSSRENYDNAKLYCYNLSGNLASLTTSKEVEFVLDEIQKYTQQKvSPWVGLRKINISY-WGWEDM 399
Cdd:smart00034   1 CPSGWISYGGKCYKFSTEKKTWEDAQAFCQSLGGHLASIHSEAENDFVASLLKNSGSSD-YYWIGLSDPDSNGsWQWSDG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2462518349  400 SPFTNTTLqWLPGEPNDS-GFCAYLeRAAVAGLKANPCTSmANGLVCE 446
Cdd:smart00034  80 SGPVSYSN-WAPGEPNNSsGDCVVL-STSGGKWNDVSCTS-KLPFVCE 124
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 586-631 2.11e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.42  E-value: 2.11e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462518349 586 ACQCNGHSTciNNNVCEQ------CKNLTTGKQCQDCMPGYYGDPTNGGQCT 631
Cdd:cd00055     1 PCDCNGHGS--LSGQCDPgtgqceCKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 462-511 5.48e-06

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 44.24  E-value: 5.48e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462518349 462 PCSLRTSCSNCT-SNGMECMWCSSTKRCVDSNAYiiSFPYGQCLEWQTATC 511
Cdd:pfam01437   1 RCSQYTSCSSCLaARDPYCGWCSSEGRCVRRSAC--GAPEGNCEEWEQASS 49
Kelch_3 pfam13415
Galactose oxidase, central domain;
51-102 1.65e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.05  E-value: 1.65e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462518349  51 TKSIYVHGGYKALPGNKYglvDDLYKYEVNTKTWTILKESGFARYLHSAVLI 102
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRL---NDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
PLN02153 PLN02153
epithiospecifier protein
 27-173 2.63e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 47.29  E-value: 2.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349  27 WLVPETKGAIVQG---GYGHTSVYDEItksiYVHGGykALPGNKYgLVDDLYKYEVNTKTWTILKESGFARYLHS----A 99
Cdd:PLN02153    9 WIKVEQKGGKGPGprcSHGIAVVGDKL----YSFGG--ELKPNEH-IDKDLYVFDFNTHTWSIAPANGDVPRISClgvrM 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462518349 100 VLINGAMLIFGGNTHNdtslsngaKCFSaDFLAYDIACDEWKILPKPNLHRDVN-RFGHSAVVINGSMYIFGGFS 173
Cdd:PLN02153   82 VAVGTKLYIFGGRDEK--------REFS-DFYSYDTVKNEWTFLTKLDEEGGPEaRTFHSMASDENHVYVFGGVS 147
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 587-630 2.31e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 39.64  E-value: 2.31e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462518349 587 CQCNGHSTciNNNVCEQ------CKNLTTGKQCQDCMPGYYGDP-TNGGQC 630
Cdd:pfam00053   1 CDCNPHGS--LSDTCDPetgqclCKPGVTGRHCDRCKPGYYGLPsDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
587-627 1.49e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 37.29  E-value: 1.49e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 2462518349  587 CQCNG----HSTCINNN-VCEqCKNLTTGKQCQDCMPGYYGDPTNG 627
Cdd:smart00180   1 CDCDPggsaSGTCDPDTgQCE-CKPNVTGRRCDRCAPGYYGDGPPG 45
 
Name Accession Description Interval E-value
CLECT_attractin_like cd03597
C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and ...
 321-447 1.80e-81

C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP); CLECT_attractin_like: C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP). CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. Mouse AtrN (the product of the mahogany gene) has been shown to bind Agouti protein and to function in agouti-induced pigmentation and obesity. Mutations in AtrN have also been shown to cause spongiform encephalopathy and hypomyelination in rats and hamsters. The cytoplasmic region of mouse ALP has been shown to binds to melanocortin receptor (MCR4). Signaling through MCR4 plays a role in appetite suppression. Attractin may have therapeutic potential in the treatment of obesity. Human attractin (hAtrN) has been shown to be expressed on activated T cells and released extracellularly. The circulating serum attractin induces the spreading of monocytes that become the focus of the clustering of non-proliferating T cells.


Pssm-ID: 153067  Cd Length: 129  Bit Score: 259.05  E-value: 1.80e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349 321 CGEGWSHIGDACLRVNSSRENYDNAKLYCYNLSGNLASLTTSKEVEFVLDEIQK--YTQQKVSPWVGLRKINISYWGWED 398
Cdd:cd03597     1 CGEGWHLVGNSCLKINTARESYDNAKLYCRNLNAVLASLTTQKKVEFVLKELQKhqMTKQKLTPWVGLRKINVSYWCWED 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2462518349 399 MSPFTNTTLQWLPGEPNDSGFCAYLERAAVAGLKANPCTSMANGLVCEK 447
Cdd:cd03597    81 MSPFTNTTLQWLPGEPSDAGFCGYLEEPAVSGLKANPCTNPVNGSVCER 129
CLECT cd00037
C-type lectin (CTL)/C-type lectin-like (CTLD) domain; CLECT: C-type lectin (CTL)/C-type ...
 332-447 2.90e-16

C-type lectin (CTL)/C-type lectin-like (CTLD) domain; CLECT: C-type lectin (CTL)/C-type lectin-like (CTLD) domain; protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. This group is chiefly comprised of eukaryotic CTLDs, but contains some, as yet functionally uncharacterized, bacterial CTLDs. Many CTLDs are calcium-dependent carbohydrate binding modules; other CTLDs bind protein ligands, lipids, and inorganic surfaces, including CaCO3 and ice. Animal C-type lectins are involved in such functions as extracellular matrix organization, endocytosis, complement activation, pathogen recognition, and cell-cell interactions. For example: mannose-binding lectin and lung surfactant proteins A and D bind carbohydrates on surfaces (e.g. pathogens, allergens, necrotic, and apoptotic cells) and mediate functions associated with killing and phagocytosis; P (platlet)-, E (endothelial)-, and L (leukocyte)- selectins (sels) mediate the initial attachment, tethering, and rolling of lymphocytes on inflamed vascular walls enabling subsequent lymphocyte adhesion and transmigration. CTLDs may bind a variety of carbohydrate ligands including mannose, N-acetylglucosamine, galactose, N-acetylgalactosamine, and fucose. Several CTLDs bind to protein ligands, and only some of these binding interactions are Ca2+-dependent; including the CTLDs of Coagulation Factors IX/X (IX/X) and Von Willebrand Factor (VWF) binding proteins, and natural killer cell receptors. C-type lectins, such as lithostathine, and some type II antifreeze glycoproteins function in a Ca2+-independent manner to bind inorganic surfaces. Many proteins in this group contain a single CTLD; these CTLDs associate with each other through several different surfaces to form dimers, trimers, or tetramers, from which ligand-binding sites project in different orientations. Various vertebrate type 1 transmembrane proteins including macrophage mannose receptor, endo180, phospholipase A2 receptor, and dendritic and epithelial cell receptor (DEC205) have extracellular domains containing 8 or more CTLDs; these CTLDs remain in the parent model. In some members (IX/X and VWF binding proteins), a loop extends to the adjoining domain to form a loop-swapped dimer. A similar conformation is seen in the macrophage mannose receptor CRD4's putative non-sugar bound form of the domain in the acid environment of the endosome. Lineage specific expansions of CTLDs have occurred in several animal lineages including Drosophila melanogaster and Caenorhabditis elegans; these CTLDs also remain in the parent model.


Pssm-ID: 153057 [Multi-domain]  Cd Length: 116  Bit Score: 75.73  E-value: 2.90e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349 332 CLRVNSSRENYDNAKLYCYNLSGNLASLTTSKEVEFVLDEIQKYTQQKVspWVGLRKINI-SYWGWEDMSPFTNTTlQWL 410
Cdd:cd00037     2 CYKFSTEKLTWEEAQEYCRSLGGHLASIHSEEENDFLASLLKKSSSSDV--WIGLNDLSSeGTWKWSDGSPLVDYT-NWA 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2462518349 411 PGEPN--DSGFCAYLERAAVAGLKANPCTSMaNGLVCEK 447
Cdd:cd00037    79 PGEPNpgGSEDCVVLSSSSDGKWNDVSCSSK-LPFICEK 116
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
54-185 5.37e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 76.35  E-value: 5.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349  54 IYVHGGYKALpgnkyGLVDDLYKYEVNTKTWTILKE-SGFARYLHSAVLINGAMLIFGGNTHNDTSLSngakcFSADFLA 132
Cdd:COG3055    25 VYVAGGLSGG-----SASNSFEVYDPATNTWSELAPlPGPPRHHAAAVAQDGKLYVFGGFTGANPSST-----PLNDVYV 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462518349 133 YDIACDEW-KILPKPnlhrdVNRFGHSAVVINGSMYIFGGFS-SVLLNDILVYKP 185
Cdd:COG3055    95 YDPATNTWtKLAPMP-----TPRGGATALLLDGKIYVVGGWDdGGNVAWVEVYDP 144
Lectin_C pfam00059
Lectin C-type domain; This family includes both long and short form C-type
 339-447 6.00e-15

Lectin C-type domain; This family includes both long and short form C-type


Pssm-ID: 459655 [Multi-domain]  Cd Length: 105  Bit Score: 71.35  E-value: 6.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349 339 RENYDNAKLYCYNLSGNLASLTTSKEVEFVLDEIQKYtqqKVSPWVGLRKINIS-YWGWEDMSPFTNTTLQWLPGEPNDS 417
Cdd:pfam00059   1 SKTWDEAREACRKLGGHLVSINSAEELDFLSSTLKKS---NKYFWIGLTDRKNEgTWKWVDGSPVNYTNWAPEPNNNGEN 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462518349 418 GFCAYLERAAvAGLKANPCTSMaNGLVCEK 447
Cdd:pfam00059  78 EDCVELSSSS-GKWNDENCNSK-NPFVCEK 105
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
23-174 1.63e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 74.81  E-value: 1.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349  23 ASNTWlvpETKGAIVQGGYGH--TSVYDEitkSIYVHGGYKALPGNkYGLVDDLYKYEVNTKTWTILKESGFARYLHSAV 100
Cdd:COG3055    46 ATNTW---SELAPLPGPPRHHaaAVAQDG---KLYVFGGFTGANPS-STPLNDVYVYDPATNTWTKLAPMPTPRGGATAL 118

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462518349 101 LINGAMLIFGGNTHNDtslsngakcFSADFLAYDIACDEWKILPKPNlhrdVNRFGHSAVVI-NGSMYIFGGFSS 174
Cdd:COG3055   119 LLDGKIYVVGGWDDGG---------NVAWVEVYDPATGTWTQLAPLP----TPRDHLAAAVLpDGKILVIGGRNG 180
CLECT smart00034
C-type lectin (CTL) or carbohydrate-recognition domain (CRD); Many of these domains function ...
 321-446 3.11e-14

C-type lectin (CTL) or carbohydrate-recognition domain (CRD); Many of these domains function as calcium-dependent carbohydrate binding modules.


Pssm-ID: 214480 [Multi-domain]  Cd Length: 124  Bit Score: 70.32  E-value: 3.11e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349  321 CGEGWSHIGDACLRVNSSRENYDNAKLYCYNLSGNLASLTTSKEVEFVLDEIQKYTQQKvSPWVGLRKINISY-WGWEDM 399
Cdd:smart00034   1 CPSGWISYGGKCYKFSTEKKTWEDAQAFCQSLGGHLASIHSEAENDFVASLLKNSGSSD-YYWIGLSDPDSNGsWQWSDG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2462518349  400 SPFTNTTLqWLPGEPNDS-GFCAYLeRAAVAGLKANPCTSmANGLVCE 446
Cdd:smart00034  80 SGPVSYSN-WAPGEPNNSsGDCVVL-STSGGKWNDVSCTS-KLPFVCE 124
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
23-171 8.61e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 72.88  E-value: 8.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349  23 ASNTWlvpETKGAIVQGGYGHTSVYdeITKSIYVHGGYkalpgNKYGLVDDLYKYEVNTKTWTILKESGFARYLHSA-VL 101
Cdd:COG3055    98 ATNTW---TKLAPMPTPRGGATALL--LDGKIYVVGGW-----DDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAaVL 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349 102 INGAMLIFGGNT--------------------HNDTSLSN------GAKCFSADFLAYDIACDEWKILPKPNlhrdVNRF 155
Cdd:COG3055   168 PDGKILVIGGRNgsgfsntwttlaplptaragHAAAVLGGkilvfgGESGFSDEVEAYDPATNTWTALGELP----TPRH 243

                         170
                  ....*....|....*.
gi 2462518349 156 GHSAVVINGSMYIFGG 171
Cdd:COG3055   244 GHAAVLTDGKVYVIGG 259
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
83-185 1.80e-11

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 65.95  E-value: 1.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349  83 TWTILKESGFARYLHSAVLINGAMLIFGGNTHNDTslsngakcfSADFLAYDIACDEWKILPKPNLHRdvnRFGHSAVVI 162
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSA---------SNSFEVYDPATNTWSELAPLPGPP---RHHAAAVAQ 69

                          90       100
                  ....*....|....*....|....*...
gi 2462518349 163 NGSMYIFGGF-----SSVLLNDILVYKP 185
Cdd:COG3055    70 DGKLYVFGGFtganpSSTPLNDVYVYDP 97
CLECT_DC-SIGN_like cd03590
C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific ...
 321-447 1.44e-08

C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR); CLECT_DC-SIGN_like: C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR). This group also contains proteins similar to hepatic asialoglycoprotein receptor (ASGP-R) and langerin in human. These proteins are type II membrane proteins with a CTLD ectodomain. CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. DC-SIGN is thought to mediate the initial contact between dendritic cells and resting T cells, and may also mediate the rolling of DCs on epithelium. DC-SIGN and DC-SIGNR bind to oligosaccharides present on human tissues, as well as, on pathogens including parasites, bacteria, and viruses. DC-SIGN and DC-SIGNR bind to HIV enhancing viral infection of T cells. DC-SIGN and DC-SIGNR are homotetrameric, and contain four CTLDs stabilized by a coiled coil of alpha helices. The hepatic ASGP-R is an endocytic recycling receptor which binds and internalizes desialylated glycoproteins having a terminal galactose or N-acetylgalactosamine residues on their N-linked carbohydrate chains, via the clathrin-coated pit mediated endocytic pathway, and delivers them to lysosomes for degradation. It has been proposed that glycoproteins bearing terminal Sia (sialic acid) alpha2, 6GalNAc and Sia alpha2, 6Gal are endogenous ligands for ASGP-R and that ASGP-R participates in regulating the relative concentration of serum glycoproteins bearing alpha 2,6-linked Sia. The human ASGP-R is a hetero-oligomer composed of two subunits, both of which are found within this group. Langerin is expressed in a subset of dendritic leukocytes, the Langerhans cells (LC). Langerin induces the formation of Birbeck Granules (BGs) and associates with these BGs following internalization. Langerin binds, in a calcium-dependent manner, to glyco-conjugates containing mannose and related sugars mediating their uptake and degradation. Langerin molecules oligomerize as trimers with three CTLDs held together by a coiled-coil of alpha helices.


Pssm-ID: 153060 [Multi-domain]  Cd Length: 126  Bit Score: 53.85  E-value: 1.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349 321 CGEGWSHIGDACLRVNSSRENYDNAKLYCYNLSGNLASLTTSKEVEFvldeIQKYTQQKVSPWVGLRKINI-SYWGWEDM 399
Cdd:cd03590     1 CPTNWKSFQSSCYFFSTEKKSWEESRQFCEDMGAHLVIINSQEEQEF----ISKILSGNRSYWIGLSDEETeGEWKWVDG 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462518349 400 SPFTNTTLQWLPGEPNDSGF----CAYLeRAAVAGLKANPCTsMANGLVCEK 447
Cdd:cd03590    77 TPLNSSKTFWHPGEPNNWGGggedCAEL-VYDSGGWNDVPCN-LEYRWICEK 126
CLECT_NK_receptors_like cd03593
C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs); ...
 321-447 2.81e-07

C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs); CLECT_NK_receptors_like: C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs), including proteins similar to oxidized low density lipoprotein (OxLDL) receptor (LOX-1), CD94, CD69, NKG2-A and -D, osteoclast inhibitory lectin (OCIL), dendritic cell-associated C-type lectin-1 (dectin-1), human myeloid inhibitory C-type lectin-like receptor (MICL), mast cell-associated functional antigen (MAFA), killer cell lectin-like receptors: subfamily F, member 1 (KLRF1) and subfamily B, member 1 (KLRB1), and lys49 receptors. CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. NKRs are variously associated with activation or inhibition of natural killer (NK) cells. Activating NKRs stimulate cytolysis by NK cells of virally infected or transformed cells; inhibitory NKRs block cytolysis upon recognition of markers of healthy self cells. Most Lys49 receptors are inhibitory; some are stimulatory. OCIL inhibits NK cell function via binding to the receptor NKRP1D. Murine OCIL in addition to inhibiting NK cell function inhibits osteoclast differentiation. MAFA clusters with the type I Fc epsilon receptor (FcepsilonRI) and inhibits the mast cells secretory response to FcepsilonRI stimulus. CD72 is a negative regulator of B cell receptor signaling. NKG2D is an activating receptor for stress-induced antigens; human NKG2D ligands include the stress induced MHC-I homologs, MICA, MICB, and ULBP family of glycoproteins Several NKRs have a carbohydrate-binding capacity which is not mediated through calcium ions (e.g. OCIL binds a range of high molecular weight sulfated glycosaminoglycans including dextran sulfate, fucoidan, and gamma-carrageenan sugars). Dectin-1 binds fungal beta-glucans and in involved in the innate immune responses to fungal pathogens. MAFA binds saccharides having terminal alpha-D mannose residues in a calcium-dependent manner. LOX-1 is the major receptor for OxLDL in endothelial cells and thought to play a role in the pathology of atherosclerosis. Some NKRs exist as homodimers (e.g.Lys49, NKG2D, CD69, LOX-1) and some as heterodimers (e.g. CD94/NKG2A). Dectin-1 can function as a monomer in vitro.


Pssm-ID: 153063  Cd Length: 116  Bit Score: 50.02  E-value: 2.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349 321 CGEGWSHIGDACLRVNSSRENYDNAKLYCYNLSGNLASLTTSKEVEFvldeIQKYTQQKvSPWVGLRKINISY-WGWEDM 399
Cdd:cd03593     1 CPKDWICYGNKCYYFSMEKKTWNESKEACSSKNSSLLKIDDEEELEF----LQSQIGSS-SYWIGLSREKSEKpWKWIDG 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2462518349 400 SPFTNttlqWL-PGEPNDSGFCAYLERaavAGLKANPCtSMANGLVCEK 447
Cdd:cd03593    76 SPLNN----LFnIRGSTKSGNCAYLSS---TGIYSEDC-STKKRWICEK 116
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
22-115 7.49e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 51.70  E-value: 7.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349  22 SASNTWlvpETKGAIVQGGYGHTSVYdeITKSIYVHGGYkalpgnkYGLVDDLYKYEVNTKTWTILKESGFARYLHSAVL 101
Cdd:COG3055   182 GFSNTW---TTLAPLPTARAGHAAAV--LGGKILVFGGE-------SGFSDEVEAYDPATNTWTALGELPTPRHGHAAVL 249

                          90
                  ....*....|....
gi 2462518349 102 INGAMLIFGGNTHN 115
Cdd:COG3055   250 TDGKVYVIGGETKP 263
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 586-631 2.11e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.42  E-value: 2.11e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462518349 586 ACQCNGHSTciNNNVCEQ------CKNLTTGKQCQDCMPGYYGDPTNGGQCT 631
Cdd:cd00055     1 PCDCNGHGS--LSGQCDPgtgqceCKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 462-511 5.48e-06

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 44.24  E-value: 5.48e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462518349 462 PCSLRTSCSNCT-SNGMECMWCSSTKRCVDSNAYiiSFPYGQCLEWQTATC 511
Cdd:pfam01437   1 RCSQYTSCSSCLaARDPYCGWCSSEGRCVRRSAC--GAPEGNCEEWEQASS 49
CLECT_DGCR2_like cd03599
C-type lectin-like domain (CTLD) of the type found in DGCR2, an integral membrane protein ...
 321-425 1.52e-05

C-type lectin-like domain (CTLD) of the type found in DGCR2, an integral membrane protein deleted in DiGeorge Syndrome (DGS); CLECT_DGCR2_like: C-type lectin-like domain (CTLD) of the type found in DGCR2, an integral membrane protein deleted in DiGeorge Syndrome (DGS). CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. DGS is also known velo-cardio-facial syndrome (VCFS). DGS is a genetic abnormality that results in malformations of the heart, face, and limbs and is associated with schizophrenia and depressive disorders. DGCR2 is a candidate for involvement in the pathogenesis of DGS since the DGCR2 gene lies within the minimal DGS critical region (MDGRC) of 22q11, which when deleted gives rise to DGS, and the DGCR2 gene is in close proximity to the balanced translocation breakpoint in a DGS patient having a balanced translocation.


Pssm-ID: 153069  Cd Length: 153  Bit Score: 46.06  E-value: 1.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349 321 CGEGWSHI-GDA-CLRVNSSRENYDNAKLYCYNLSGNLASLTTSKEVEFVL------DEIQKYTQQKVSPWVGLRKI--- 389
Cdd:cd03599     1 CPSGWHHYeGTAsCYKVYLSGENYWDAVQTCQKVNGSLATFTTDQELQFILaqewdfDERVFGRKDQCKFWVGYQYVitn 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2462518349 390 -NISYWG-WEdmSPFTNTTLQWLPGEP--------NDSGFCAYLER 425
Cdd:cd03599    81 rNHSLEGrWE--VAYKGSMEVFLPPEPifatgmstNDNVFCAQLQC 124
Kelch_3 pfam13415
Galactose oxidase, central domain;
51-102 1.65e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.05  E-value: 1.65e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462518349  51 TKSIYVHGGYKALPGNKYglvDDLYKYEVNTKTWTILKESGFARYLHSAVLI 102
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRL---NDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
CLECT_REG-1_like cd03594
C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and ...
 321-446 1.92e-05

C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2); CLECT_REG-1_like: C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2). CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. REG-1 is a proliferating factor which participates in various kinds of tissue regeneration including pancreatic beta-cell regeneration, regeneration of intestinal mucosa, regeneration of motor neurons, and perhaps in tissue regeneration of damaged heart. REG-1 may play a role on the pathophysiology of Alzheimer's disease and in the development of gastric cancers. Its expression is correlated with reduced survival from early-stage colorectal cancer. REG-1 also binds and aggregates several bacterial strains from the intestinal flora and it has been suggested that it is involved in the control of the intestinal bacterial ecosystem. Rat lithostathine has calcium carbonate crystal inhibitor activity in vitro. REG-IV is unregulated in pancreatic, gastric, hepatocellular, and prostrate adenocarcinomas. REG-IV activates the EGF receptor/Akt/AP-1 signaling pathway in colorectal carcinoma. Ansocalcin, SCA-1 and -2 are found at high concentration in the calcified egg shell layer of goose and ostrich, respectively and tend to form aggregates. Ansocalcin nucleates calcite crystal aggregates in vitro.


Pssm-ID: 153064 [Multi-domain]  Cd Length: 129  Bit Score: 45.06  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349 321 CGEGWSHIGDACLRVNSSRENYDNAKLYC--YNLSGNLASLTTSKEVEFVLDEIQKYTQQKVSPWVGLRKINISY-WGWE 397
Cdd:cd03594     1 CPKGWLPYKGNCYGYFRQPLSWSDAELFCqkYGPGAHLASIHSPAEAAAIASLISSYQKAYQPVWIGLHDPQQSRgWEWS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462518349 398 DMSPFTNTTlqWLPGEP-NDSGFCAYLER-AAVAGLKANPCTSMaNGLVCE 446
Cdd:cd03594    81 DGSKLDYRS--WDRNPPyARGGYCAELSRsTGFLKWNDANCEER-NPFICK 128
PLN02153 PLN02153
epithiospecifier protein
 27-173 2.63e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 47.29  E-value: 2.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349  27 WLVPETKGAIVQG---GYGHTSVYDEItksiYVHGGykALPGNKYgLVDDLYKYEVNTKTWTILKESGFARYLHS----A 99
Cdd:PLN02153    9 WIKVEQKGGKGPGprcSHGIAVVGDKL----YSFGG--ELKPNEH-IDKDLYVFDFNTHTWSIAPANGDVPRISClgvrM 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462518349 100 VLINGAMLIFGGNTHNdtslsngaKCFSaDFLAYDIACDEWKILPKPNLHRDVN-RFGHSAVVINGSMYIFGGFS 173
Cdd:PLN02153   82 VAVGTKLYIFGGRDEK--------REFS-DFYSYDTVKNEWTFLTKLDEEGGPEaRTFHSMASDENHVYVFGGVS 147
PHA03098 PHA03098
kelch-like protein; Provisional
 54-183 9.52e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 46.30  E-value: 9.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349  54 IYVHGGYkalpgNKYG-LVDDLYKYEVNTKTWTILKESGFARYLHSAVLINGAMLIFGGNTHndtslSNGAKCFSADFLa 132
Cdd:PHA03098  392 IYVIGGI-----SKNDeLLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISY-----IDNIKVYNIVES- 460

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462518349 133 YDIACDEWKILPKPNLHrdvnRFGHSAVVINGSMYIFGGFS-SVLLNDILVY 183
Cdd:PHA03098  461 YNPVTNKWTELSSLNFP----RINASLCIFNNKIYVVGGDKyEYYINEIEVY 508
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 587-630 2.31e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 39.64  E-value: 2.31e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462518349 587 CQCNGHSTciNNNVCEQ------CKNLTTGKQCQDCMPGYYGDP-TNGGQC 630
Cdd:pfam00053   1 CDCNPHGS--LSDTCDPetgqclCKPGVTGRHCDRCKPGYYGLPsDPPQGC 49
CLECT_CEL-1_like cd03589
C-type lectin-like domain (CTLD) of the type found in CEL-1 from Cucumaria echinata and ...
 321-437 3.47e-04

C-type lectin-like domain (CTLD) of the type found in CEL-1 from Cucumaria echinata and Echinoidin from Anthocidaris crassispina; CLECT_CEL-1_like: C-type lectin-like domain (CTLD) of the type found in CEL-1 from Cucumaria echinata and Echinoidin from Anthocidaris crassispina. CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. The CEL-1 CTLD binds three calcium ions and has a high specificity for N-acteylgalactosamine (GalNAc). CEL-1 exhibits strong cytotoxicity which is inhibited by GalNAc. This protein may play a role as a toxin defending against predation. Echinoidin is found in the coelomic fluid of the sea urchin and is specific for GalBeta1-3GalNAc. Echinoidin has a cell adhesive activity towards human cancer cells which is not mediated through the CTLD. Both CEL-1 and Echinoidin are multimeric proteins comprised of multiple dimers linked by disulfide bonds.


Pssm-ID: 153059  Cd Length: 137  Bit Score: 41.57  E-value: 3.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349 321 CGEGWSHIGDACLRVNSSRENYDNAKLYCYN-----LSGNLASLTTSKEVEFVLD--EIQKYTQQKVSPWVGL-RKINIS 392
Cdd:cd03589     1 CPTFWTAFGGYCYRFFGDRLTWEEAELRCRSfsipgLIAHLVSIHSQEENDFVYDlfESSRGPDTPYGLWIGLhDRTSEG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462518349 393 YWGWEDMSPFTNTtlQWLPGEPNDSGF---CAYLERAAVAGLKAN--PCT 437
Cdd:cd03589    81 PFEWTDGSPVDFT--KWAGGQPDNYGGnedCVQMWRRGDAGQSWNdmPCD 128
PLN02193 PLN02193
nitrile-specifier protein
 16-214 4.14e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 43.79  E-value: 4.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349  16 TLSCFISASNT------WLVPETKGAivqgGYGHTSVYD--EITKSIYVHGG--YKALPGNKYglvddLYKYEVNTKTWT 85
Cdd:PLN02193  136 SLGAYISLPSTpkllgkWIKVEQKGE----GPGLRCSHGiaQVGNKIYSFGGefTPNQPIDKH-----LYVFDLETRTWS 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349  86 ILKESGFARYLH----SAVLINGAMLIFGGnthNDTSLS-NGakcfsadFLAYDIACDEWKIL------PKPnlhrdvnR 154
Cdd:PLN02193  207 ISPATGDVPHLSclgvRMVSIGSTLYVFGG---RDASRQyNG-------FYSFDTTTNEWKLLtpveegPTP-------R 269

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462518349 155 FGHSAVVINGSMYIFGGFSS-VLLNDILVYKPPNCKAFR----DEELCKNAGPGIKCVWNK-------NHCE 214
Cdd:PLN02193  270 SFHSMAADEENVYVFGGVSAtARLKTLDSYNIVDKKWFHcstpGDSFSIRGGAGLEVVQGKvwvvygfNGCE 341
CLECT_CSPGs cd03588
C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core ...
 321-421 4.31e-04

C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins; CLECT_CSPGs: C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins (CSPGs) in human and chicken aggrecan, frog brevican, and zebra fish dermacan. CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Xenopus brevican is expressed in the notochord and the brain during early embryogenesis. Zebra fish dermacan is expressed in dermal bones and may play a role in dermal bone development. CSPGs do contain LINK domain(s) which bind HA. These LINK domains are considered by one classification system to be a variety of CTLD, but are omitted from this hierarchical classification based on insignificant sequence similarity.


Pssm-ID: 153058  Cd Length: 124  Bit Score: 41.02  E-value: 4.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349 321 CGEGWSHIGDACLRVNSSRENYDNAKLYCYNLSGNLASLTTSKEVEFVLDEIQKYTqqkvspWVGLRKINISY-WGWEDM 399
Cdd:cd03588     1 CEEGWDKFQGHCYRHFPDRETWEDAERRCREQQGHLSSIVTPEEQEFVNNNAQDYQ------WIGLNDRTIEGdFRWSDG 74

                          90       100
                  ....*....|....*....|....
gi 2462518349 400 SP--FTNttlqWLPGEPnDSGFCA 421
Cdd:cd03588    75 HPlqFEN----WRPNQP-DNFFAT 93
Kelch_4 pfam13418
Galactose oxidase, central domain;
42-87 5.07e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.75  E-value: 5.07e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462518349  42 GHTSVYDEiTKSIYVHGGYkalpGNKYGLVDDLYKYEVNTKTWTIL 87
Cdd:pfam13418   4 YHTSTSIP-DDTIYLFGGE----GEDGTLLSDLWVFDLSTNEWTRL 44
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
587-627 1.49e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 37.29  E-value: 1.49e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 2462518349  587 CQCNG----HSTCINNN-VCEqCKNLTTGKQCQDCMPGYYGDPTNG 627
Cdd:smart00180   1 CDCDPggsaSGTCDPDTgQCE-CKPNVTGRRCDRCAPGYYGDGPPG 45
PRK14131 PRK14131
N-acetylneuraminate epimerase;
72-178 1.82e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.54  E-value: 1.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349  72 DDLYKYEVNT--KTWTILKE-SGFARYLHSAVLINGAMLIFGGNTHNDTSLSNGAkcFSaDFLAYDIACDEWKilpKPNL 148
Cdd:PRK14131   50 TSWYKLDLNApsKGWTKIAAfPGGPREQAVAAFIDGKLYVFGGIGKTNSEGSPQV--FD-DVYKYDPKTNSWQ---KLDT 123

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2462518349 149 HRDVNRFGHSAVVINGSM-YIFGGFSSVLLN 178
Cdd:PRK14131  124 RSPVGLAGHVAVSLHNGKaYITGGVNKNIFD 154
CLECT_selectins_like cd03592
C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P ...
 333-418 3.15e-03

C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels); CLECT_selectins_like: C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels). CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. P- E- and L-sels are cell adhesion receptors that mediate the initial attachment, tethering, and rolling of lymphocytes on inflamed vascular walls enabling subsequent lymphocyte adhesion and transmigration. L- sel is expressed constitutively on most leukocytes. P-sel is stored in the Weibel-Palade bodies of endothelial cells and in the alpha granules of platlets. E- sels are present on endothelial cells. Following platelet and/or endothelial cell activation P- sel is rapidly translocated to the cell surface and E-sel expression is induced. The initial step in leukocyte migration involves interactions of selectins with fucosylated, sialylated, and sulfated carbohydrate moieties on target ligands displayed on glycoprotein scaffolds on endothelial cells and leucocytes. A major ligand of P- E- and L-sels is PSGL-1 (P-sel glycoprotein ligand). Interactions of E- and P- sels with tumor cells may promote extravasation of cancer cells. Regulation of L-sel and P-sel function includes proteolytic shedding of the most extracellular portion (containing the CTLD) from the cell surface. Increased levels of the soluble form of P-sel in the plasma have been found in a number of diseases including coronary disease and diabetes. E- and P- sel also play roles in the development of synovial inflammation in inflammatory arthritis. Platelet P-sel, but not endothelial P-sel, plays a role in the inflammatory response and neointimal formation after arterial injury. Selectins may also function as signal-transducing receptors.


Pssm-ID: 153062  Cd Length: 115  Bit Score: 38.51  E-value: 3.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462518349 333 LRVNSSRENYDNAKLYCYNLSGNLASLTTSKEVEFVLDEIQKYTQQKVspWVGLRKINISyWGWEDMSPFTNTTLQWLPG 412
Cdd:cd03592     3 YHYSTEKMTFNEAVKYCKSRGTDLVAIQNAEENALLNGFALKYNLGYY--WIDGNDINNE-GTWVDTDKKELEYKNWAPG 79


                  ....*.
gi 2462518349 413 EPNDSG 418
Cdd:cd03592    80 EPNNGR 85
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 154-187 4.12e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 36.00  E-value: 4.12e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2462518349 154 RFGHSAVVINGSMYIFGGFSS---VLLNDILVYKPPN 187
Cdd:pfam13854   4 RYGHCAVTVGDYIYLYGGYTGgegQPSDDVYVLSLPT 40
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 154-185 4.23e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.05  E-value: 4.23e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2462518349 154 RFGHSAVVINGSMYIFGGF-SSVLLNDILVYKP 185
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFdGNQSLNSVEVYDP 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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