LA motif RNA-binding domain; This domain is found at the N-terminus of La RNA-binding proteins as well as in other related proteins. Typically, the domain co-occurs with an RNA-recognition motif (RRM), and together these domains function to bind primary transcripts of RNA polymerase III in the La autoantigen (Lupus La protein, LARP3, or Sjoegren syndrome type B antigen, SS-B). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462518097  26 MDSDQYVPITTVANLDHIKKLSTDVDLIVEVLRSLPLVQVDEKGEKVRP 74
Cdd:cd08036    27 MDSDQYVPIMTVANLDHIKKLSTDVDLIVDVLRSLPLVQVDEKGEKVRP 75

La RNA-binding domain of La-related protein 5; This domain is found in vertebrate La-related protein 5 (LARP5). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462518097  26 MDSDQYVPITTVANLDHIKKLSTDVDLIVEVLRSLPLVQVDEKGEKVRP 74
Cdd:cd08036    27 MDSDQYVPIMTVANLDHIKKLSTDVDLIVDVLRSLPLVQVDEKGEKVRP 75

RNA recognition motif;

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462518097   81 VILREISESTPVEEVEALFKgdNLPKFINCEFAYNDNW-------FITFETEADAQQAYKYLREevKTFQGKPIK 148
Cdd:smart00360   2 LFVGNLPPDTTEEELRELFS--KFGKVESVRLVRDKETgkskgfaFVEFESEEDAEKALEALNG--KELDGRPLK 72

RNA recognition motif (RRM) found in La-related protein 4 (LARP4), La-related protein 5 (LARP5 or LARP4B) and similar proteins; This subfamily corresponds to the RRM of LARP4 and LARP5. LARP4 is a cytoplasmic factor that can bind poly(A) RNA and interact with poly(A) binding protein (PABP). It may play a role in promoting translation by stabilizing mRNA. LARP5 is a cytosolic protein that co-sediments with polysomes and accumulates upon stress induction in cellular stress granules. It can interact with the cytosolic poly(A) binding protein 1 (PABPC1) and the receptor for activated C Kinase (RACK1), a component of the 40S ribosomal subunit. LARP5 may function as a stimulatory factor of translation through bridging mRNA factors of the 3' end with initiating ribosomes. Both, LARP4 and LARP5, are structurally related to the La autoantigen. Like other La-related proteins (LARPs) family members, LARP4 and LARP5 contain a La motif (LAM) and an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain).

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462518097  79 CIVILREISESTPVEEVEALFKGDNLPKFINCEFAYNDNWFITFETEADAQQAYKYLREEVKTFQGKPIKARIKAK 154
Cdd:cd12430     1 CIVILREIPESTPEEEVEALFSGQNCPKFTSCEFAINDSWYVTFESEEDAQEAYKYLREEVKTFNGKPIMARIKAE 76

La RNA-binding domain of La-related protein 5; This domain is found in vertebrate La-related protein 5 (LARP5). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462518097  26 MDSDQYVPITTVANLDHIKKLSTDVDLIVEVLRSLPLVQVDEKGEKVRP 74
Cdd:cd08036    27 MDSDQYVPIMTVANLDHIKKLSTDVDLIVDVLRSLPLVQVDEKGEKVRP 75

La RNA-binding domain of La-related protein 4; This domain is found in vertebrate La-related protein 4 (LARP4), also known as c-MPL binding protein. La-type domains often co-occur with RNA-recognition motifs (RRMs). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462518097  26 MDSDQYVPITTVANLDHIKKLSTDVDLIVEVLRSLPLVQVDEKGEKVRP 74
Cdd:cd08035    27 MDSDQFVPIWTVANMEGIKKLTTDMDLILDVLRSSPMVQVDETGEKVRP 75

LA motif RNA-binding domain; This domain is found at the N-terminus of La RNA-binding proteins as well as in other related proteins. Typically, the domain co-occurs with an RNA-recognition motif (RRM), and together these domains function to bind primary transcripts of RNA polymerase III in the La autoantigen (Lupus La protein, LARP3, or Sjoegren syndrome type B antigen, SS-B). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462518097  26 MDSDQYVPITTVANLDHIKKLSTDVDLIVEVLRSLPLVQVDEKGEKVRP 74
Cdd:cd07323    27 MDDDGWVPLSLLASFNRVKKLTTDVELILEALRDSSVVEVSEDGTKVRR 75

La RNA-binding domain proteins similar to La-related proteins 1 and 2; This domain is found in proteins similar to vertebrate La-related proteins 1 and 2 (LARP1, LARP2). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2462518097  26 MDSDQYVPITTVANLDHIKKLSTDVDLIVEVLRSLPLVQVDekGEKVR 73
Cdd:cd08034    27 MDPEGYLPIALIASFHRVQALTTDVNLILEALKDSTVVELV--DEKVR 72

La RNA-binding domain of La-related protein 7; LARP7 is a component of the 7SK snRNP, a key factor in the regulation of RNA polymerase II transcription. 7SK functionality is dependent on the presence of LARP7, which is thought to stabilize the 7SK RNA by interacting with its 3' end. The release of 7SK RNA from P-TEFb/HEXIM/7SK complexes activates the cyclin-dependent kinase P-TEFb, which in turn phosphorylates the C-terminal domain of RNA pol II and mediates a transition into productive transcription elongation.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462518097  24 ITMDSDQYVPITTVANLDHIKKLSTDVDLIVEVLRSLPLVQVDEKGEKVR 73
Cdd:cd08032    32 IEKSRDGYIDISLLVSFNKMKKLTTDGKLIARALKNSSVVELNLEGTRIR 81

La RNA-binding domain of La-related protein 3; This domain is found at the N-terminus of the La autoantigen and similar proteins, and co-occurs with an RNA-recognition motif (RRM). Together these domains function to bind primary transcripts of RNA polymerase III at their 3' terminus and protect them from exonucleolytic degradation. Binding is specific for the 3'-terminal UUU-OH motif. The La autoantigen is also called Lupus La protein, LARP3, or Sjoegren syndrome type B antigen (SS-B).

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2462518097  28 SDQYVPITTVANLDHIKKLSTDVDLIVEVLR--SLPLVQVDEKGEKVR 73
Cdd:cd08028    34 DDGWVPMEVMLKFNRLKSLSSDPEVIAKALKksKSGLIEVSEDKTKIR 81

La RNA-binding domain of La-related protein 2; This domain is found in vertebrate La-related protein 2 (LARP2). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2462518097  26 MDSDQYVPITTVANLDHIKKLSTDVDLIVEVLR-SLPLVQVDEK 68
Cdd:cd08038    27 MDLQGFLPISLIAGFYRVQALTTNVDLILEALKdSTEVEIVDQK 70