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Conserved domains on  [gi|2462624897|ref|XP_054219031|]
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alpha/beta hydrolase domain-containing protein 17B isoform X3 [Homo sapiens]

Protein Classification

alpha/beta hydrolase( domain architecture ID 11437497)

alpha/beta hydrolase catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917|37582413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 58-225 4.42e-23

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


:

Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 93.44  E-value: 4.42e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624897  58 YSSREKDAIECFMTRTSKGNRIACM-FVRCSPNAKY-TLLFSHGNAVDLGQMSSF---YIGLGSrincNIFSYDYSGYGA 132
Cdd:COG1073     2 FPPSDKVNKEDVTFKSRDGIKLAGDlYLPAGASKKYpAVVVAHGNGGVKEQRALYaqrLAELGF----NVLAFDYRGYGE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624897 133 SSGKPTEKNLYA--DIEAAWLALRT------------------------------------------------------- 155
Cdd:COG1073    78 SEGEPREEGSPErrDARAAVDYLRTlpgvdperigllgislgggyalnaaatdprvkavildspftsledlaaqrakear 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624897 156 ------------------------SIDKISKITSPVLIIHGTEDEVIDFSHGLALFERCQRPVEPLWVEGAGHND--VEL 209
Cdd:COG1073   158 gaylpgvpylpnvrlasllndefdPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPKELLIVPGAGHVDlyDRP 237

                         250
                  ....*....|....*.
gi 2462624897 210 YGQYLERLKQFVSQEL 225
Cdd:COG1073   238 EEEYFDKLAEFFKKNL 253
 
Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 58-225 4.42e-23

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 93.44  E-value: 4.42e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624897  58 YSSREKDAIECFMTRTSKGNRIACM-FVRCSPNAKY-TLLFSHGNAVDLGQMSSF---YIGLGSrincNIFSYDYSGYGA 132
Cdd:COG1073     2 FPPSDKVNKEDVTFKSRDGIKLAGDlYLPAGASKKYpAVVVAHGNGGVKEQRALYaqrLAELGF----NVLAFDYRGYGE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624897 133 SSGKPTEKNLYA--DIEAAWLALRT------------------------------------------------------- 155
Cdd:COG1073    78 SEGEPREEGSPErrDARAAVDYLRTlpgvdperigllgislgggyalnaaatdprvkavildspftsledlaaqrakear 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624897 156 ------------------------SIDKISKITSPVLIIHGTEDEVIDFSHGLALFERCQRPVEPLWVEGAGHND--VEL 209
Cdd:COG1073   158 gaylpgvpylpnvrlasllndefdPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPKELLIVPGAGHVDlyDRP 237

                         250
                  ....*....|....*.
gi 2462624897 210 YGQYLERLKQFVSQEL 225
Cdd:COG1073   238 EEEYFDKLAEFFKKNL 253
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
162-204 9.27e-05

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 42.22  E-value: 9.27e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462624897 162 KITSPVLIIHGTEDEVIDFSHGLALFERCQR---PVEPLWVEGAGH 204
Cdd:pfam00326 142 KVYPPLLLIHGLLDDRVPPWQSLKLVAALQRkgvPFLLLIFPDEGH 187
PHA02857 PHA02857
monoglyceride lipase; Provisional
 66-136 8.06e-03

monoglyceride lipase; Provisional


Pssm-ID: 165193 [Multi-domain]  Cd Length: 276  Bit Score: 36.79  E-value: 8.06e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462624897  66 IECFMTrtSKGNRIACMFVRCSPNAKYTLLFSHGNavdlGQMSSFYIGLG---SRINCNIFSYDYSGYGASSGK 136
Cdd:PHA02857    2 ANCMFN--LDNDYIYCKYWKPITYPKALVFISHGA----GEHSGRYEELAeniSSLGILVFSHDHIGHGRSNGE 69
 
Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 58-225 4.42e-23

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 93.44  E-value: 4.42e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624897  58 YSSREKDAIECFMTRTSKGNRIACM-FVRCSPNAKY-TLLFSHGNAVDLGQMSSF---YIGLGSrincNIFSYDYSGYGA 132
Cdd:COG1073     2 FPPSDKVNKEDVTFKSRDGIKLAGDlYLPAGASKKYpAVVVAHGNGGVKEQRALYaqrLAELGF----NVLAFDYRGYGE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624897 133 SSGKPTEKNLYA--DIEAAWLALRT------------------------------------------------------- 155
Cdd:COG1073    78 SEGEPREEGSPErrDARAAVDYLRTlpgvdperigllgislgggyalnaaatdprvkavildspftsledlaaqrakear 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624897 156 ------------------------SIDKISKITSPVLIIHGTEDEVIDFSHGLALFERCQRPVEPLWVEGAGHND--VEL 209
Cdd:COG1073   158 gaylpgvpylpnvrlasllndefdPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPKELLIVPGAGHVDlyDRP 237

                         250
                  ....*....|....*.
gi 2462624897 210 YGQYLERLKQFVSQEL 225
Cdd:COG1073   238 EEEYFDKLAEFFKKNL 253
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
148-225 8.21e-12

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 62.73  E-value: 8.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624897 148 AAWLALRTSIDKISKITSPVLIIHGTEDEVIDFSHGLALFERCQR---PVEPLWVEGAGHNDV-ELYGQYLERLKQFVSQ 223
Cdd:COG1506   152 PEAYAARSPLAYADKLKTPLLLIHGEADDRVPPEQAERLYEALKKagkPVELLVYPGEGHGFSgAGAPDYLERILDFLDR 231


                  ..
gi 2462624897 224 EL 225
Cdd:COG1506   232 HL 233
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
72-223 8.22e-10

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 56.93  E-value: 8.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624897  72 RTSKGNRIACMFVRCSPNAKYTLLFSHGNAVDLGQMSSFYIGLGSRiNCNIFSYDYSGYGASSGK----PTEKNLYADIE 147
Cdd:COG2267     9 PTRDGLRLRGRRWRPAGSPRGTVVLVHGLGEHSGRYAELAEALAAA-GYAVLAFDLRGHGRSDGPrghvDSFDDYVDDLR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624897 148 AAWLALRTS--------------------------------------------------------IDKISKITSPVLIIH 171
Cdd:COG2267    88 AALDALRARpglpvvllghsmggliallyaarypdrvaglvllapayradpllgpsarwlralrlAEALARIDVPVLVLH 167

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462624897 172 GTEDEVIDFSHGLALFERCQRPVEPLWVEGAGHNDV--ELYGQYLERLKQFVSQ 223
Cdd:COG2267   168 GGADRVVPPEAARRLAARLSPDVELVLLPGARHELLnePAREEVLAAILAWLER 221
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
154-225 1.40e-08

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 52.86  E-value: 1.40e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462624897 154 RTSIDKISKITSPVLIIHGTEDEVIDFSHGLALFERCQRPVEPLWVEGAGHndveLYGQYLERLKQFVSQEL 225
Cdd:COG2945   132 RYDFSFLAPCPAPTLVIHGEQDEVVPPAEVLDWARPLSPPLPVVVVPGADH----FFHGKLDELKELVARYL 199
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
158-223 3.16e-08

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 52.64  E-value: 3.16e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462624897 158 DKISKITSPVLIIHGTEDEVIDFSHGLALFERC-QRPVEPLWVEGAGH---NDVELyGQYLERLKQFVSQ 223
Cdd:COG1647   175 RDLPKITAPTLIIQSRKDEVVPPESARYIYERLgSPDKELVWLEDSGHvitLDKDR-EEVAEEILDFLER 243
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 149-223 4.77e-06

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 46.15  E-value: 4.77e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462624897 149 AWLALRTSIDKISKITSPVLIIHGTEDEVIDFSHGLALFERCQRpVEPLWVEGAGHN-DVELYGQYLERLKQFVSQ 223
Cdd:COG0596   146 RALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLPN-AELVVLPGAGHFpPLEQPEAFAAALRDFLAR 220
YpfH COG0400
Predicted esterase [General function prediction only];
166-225 5.64e-05

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 42.59  E-value: 5.64e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462624897 166 PVLIIHGTEDEVIDFSHGLALFERCQR---PVEPLWVEGaGHndvELYGQYLERLKQFVSQEL 225
Cdd:COG0400   141 PVFLAHGTQDPVIPVERAREAAEALEAagaDVTYREYPG-GH---EISPEELADARAWLAERL 199
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
162-204 9.27e-05

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 42.22  E-value: 9.27e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2462624897 162 KITSPVLIIHGTEDEVIDFSHGLALFERCQR---PVEPLWVEGAGH 204
Cdd:pfam00326 142 KVYPPLLLIHGLLDDRVPPWQSLKLVAALQRkgvPFLLLIFPDEGH 187
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
150-204 2.16e-03

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 38.02  E-value: 2.16e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462624897 150 WLALRTSIDKISKITSPVLIIHGTEDEVIDFSHGLALFERCQR---PVEPLWVEGAGH 204
Cdd:COG0412   142 GLPADDLLDLAARIKAPVLLLYGEKDPLVPPEQVAALEAALAAagvDVELHVYPGAGH 199
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 162-204 2.26e-03

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 37.96  E-value: 2.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2462624897 162 KITSPVLIIHGTEDEVIDFSHGLALFERCQRP-VEPLWVEGAGH 204
Cdd:pfam12146 188 AITVPLLLLHGGADRVVDPAGSREFYERAGSTdKTLKLYPGLYH 231
PHA02857 PHA02857
monoglyceride lipase; Provisional
 66-136 8.06e-03

monoglyceride lipase; Provisional


Pssm-ID: 165193 [Multi-domain]  Cd Length: 276  Bit Score: 36.79  E-value: 8.06e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462624897  66 IECFMTrtSKGNRIACMFVRCSPNAKYTLLFSHGNavdlGQMSSFYIGLG---SRINCNIFSYDYSGYGASSGK 136
Cdd:PHA02857    2 ANCMFN--LDNDYIYCKYWKPITYPKALVFISHGA----GEHSGRYEELAeniSSLGILVFSHDHIGHGRSNGE 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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