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Conserved domains on  [gi|2462623499|ref|XP_054218367|]
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intracellular hyaluronan-binding protein 4 isoform X3 [Homo sapiens]

Protein Classification

HABP4_PAI-RBP1 domain-containing protein( domain architecture ID 10521441)

HABP4_PAI-RBP1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HABP4_PAI-RBP1 pfam04774
Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding ...
 74-178 7.38e-19

Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1. HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo. It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan. PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability. However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.


:

Pssm-ID: 461421  Cd Length: 108  Bit Score: 79.72  E-value: 7.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462623499  74 GKREFERYGGNDKiavRTEDNMGGCGVRTWGSGKDTSDV---EPTAPMEEPTVVEESQGTPE-----EESPAKVPEleVE 145
Cdd:pfam04774   1 GKREFDRHSGTGR---GPEEKRDGAGRHNWGTVKDEIEApeeEEAENEMEKNNDAEKEAGEEetdenEEAAAAEEE--EK 75

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462623499 146 EETQVQEMTLDEWKNLQEQTRPKPEFNIRKPES 178
Cdd:pfam04774  76 EPNEDKEMTLDEYKKVQEEKRALPAFNIRKRKE 108
IHABP4_N super family cl24679
Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of ...
 182-269 1.18e-06

Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of intracellular hyaluronan-binding protein 4-like and SERPINE1 mRNA binding protein 1-like proteins. This region carries nuclear localization sites, and may also be involved in the binding to some of the partners in the translational machinery.


The actual alignment was detected with superfamily member pfam16174:

Pssm-ID: 465041 [Multi-domain]  Cd Length: 140  Bit Score: 47.10  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462623499 182 SKAVVIHKSKYRDDMVKDDYEDDSHVFRKPANDITSQLEINFGNLPRPGRGARGG--TRGGRGRIRRAENYGPRAEVVMQ 259
Cdd:pfam16174   1 MQESFGCVVTNRFDQLLDDESDPFDVLREAENKKKLQLKIKFGEKANKGKGAGPRggPRGGQARIGRKESQKDRKNDVAS 80

                          90
                  ....*....|
gi 2462623499 260 DVAPNPDDPE 269
Cdd:pfam16174  81 GQPDKPGGGG 90
IHABP4_N super family cl24679
Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of ...
 1-24 3.22e-03

Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of intracellular hyaluronan-binding protein 4-like and SERPINE1 mRNA binding protein 1-like proteins. This region carries nuclear localization sites, and may also be involved in the binding to some of the partners in the translational machinery.


The actual alignment was detected with superfamily member pfam16174:

Pssm-ID: 465041 [Multi-domain]  Cd Length: 140  Bit Score: 37.08  E-value: 3.22e-03
                          10        20
                  ....*....|....*....|....
gi 2462623499   1 MLERAERRSYREYRPYETERQADF 24
Cdd:pfam16174 117 RRERGERRPFRERRNEEDNRQGEF 140
 
Name Accession Description Interval E-value
HABP4_PAI-RBP1 pfam04774
Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding ...
 74-178 7.38e-19

Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1. HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo. It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan. PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability. However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.


Pssm-ID: 461421  Cd Length: 108  Bit Score: 79.72  E-value: 7.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462623499  74 GKREFERYGGNDKiavRTEDNMGGCGVRTWGSGKDTSDV---EPTAPMEEPTVVEESQGTPE-----EESPAKVPEleVE 145
Cdd:pfam04774   1 GKREFDRHSGTGR---GPEEKRDGAGRHNWGTVKDEIEApeeEEAENEMEKNNDAEKEAGEEetdenEEAAAAEEE--EK 75

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462623499 146 EETQVQEMTLDEWKNLQEQTRPKPEFNIRKPES 178
Cdd:pfam04774  76 EPNEDKEMTLDEYKKVQEEKRALPAFNIRKRKE 108
IHABP4_N pfam16174
Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of ...
 182-269 1.18e-06

Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of intracellular hyaluronan-binding protein 4-like and SERPINE1 mRNA binding protein 1-like proteins. This region carries nuclear localization sites, and may also be involved in the binding to some of the partners in the translational machinery.


Pssm-ID: 465041 [Multi-domain]  Cd Length: 140  Bit Score: 47.10  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462623499 182 SKAVVIHKSKYRDDMVKDDYEDDSHVFRKPANDITSQLEINFGNLPRPGRGARGG--TRGGRGRIRRAENYGPRAEVVMQ 259
Cdd:pfam16174   1 MQESFGCVVTNRFDQLLDDESDPFDVLREAENKKKLQLKIKFGEKANKGKGAGPRggPRGGQARIGRKESQKDRKNDVAS 80

                          90
                  ....*....|
gi 2462623499 260 DVAPNPDDPE 269
Cdd:pfam16174  81 GQPDKPGGGG 90
IHABP4_N pfam16174
Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of ...
 1-24 3.22e-03

Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of intracellular hyaluronan-binding protein 4-like and SERPINE1 mRNA binding protein 1-like proteins. This region carries nuclear localization sites, and may also be involved in the binding to some of the partners in the translational machinery.


Pssm-ID: 465041 [Multi-domain]  Cd Length: 140  Bit Score: 37.08  E-value: 3.22e-03
                          10        20
                  ....*....|....*....|....
gi 2462623499   1 MLERAERRSYREYRPYETERQADF 24
Cdd:pfam16174 117 RRERGERRPFRERRNEEDNRQGEF 140
 
Name Accession Description Interval E-value
HABP4_PAI-RBP1 pfam04774
Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding ...
 74-178 7.38e-19

Hyaluronan / mRNA binding family; This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1. HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo. It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan. PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability. However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.


Pssm-ID: 461421  Cd Length: 108  Bit Score: 79.72  E-value: 7.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462623499  74 GKREFERYGGNDKiavRTEDNMGGCGVRTWGSGKDTSDV---EPTAPMEEPTVVEESQGTPE-----EESPAKVPEleVE 145
Cdd:pfam04774   1 GKREFDRHSGTGR---GPEEKRDGAGRHNWGTVKDEIEApeeEEAENEMEKNNDAEKEAGEEetdenEEAAAAEEE--EK 75

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2462623499 146 EETQVQEMTLDEWKNLQEQTRPKPEFNIRKPES 178
Cdd:pfam04774  76 EPNEDKEMTLDEYKKVQEEKRALPAFNIRKRKE 108
IHABP4_N pfam16174
Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of ...
 182-269 1.18e-06

Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of intracellular hyaluronan-binding protein 4-like and SERPINE1 mRNA binding protein 1-like proteins. This region carries nuclear localization sites, and may also be involved in the binding to some of the partners in the translational machinery.


Pssm-ID: 465041 [Multi-domain]  Cd Length: 140  Bit Score: 47.10  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462623499 182 SKAVVIHKSKYRDDMVKDDYEDDSHVFRKPANDITSQLEINFGNLPRPGRGARGG--TRGGRGRIRRAENYGPRAEVVMQ 259
Cdd:pfam16174   1 MQESFGCVVTNRFDQLLDDESDPFDVLREAENKKKLQLKIKFGEKANKGKGAGPRggPRGGQARIGRKESQKDRKNDVAS 80

                          90
                  ....*....|
gi 2462623499 260 DVAPNPDDPE 269
Cdd:pfam16174  81 GQPDKPGGGG 90
IHABP4_N pfam16174
Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of ...
 1-24 3.22e-03

Intracellular hyaluronan-binding protein 4 N-terminal; IHABP4_N is the N-terminal region of intracellular hyaluronan-binding protein 4-like and SERPINE1 mRNA binding protein 1-like proteins. This region carries nuclear localization sites, and may also be involved in the binding to some of the partners in the translational machinery.


Pssm-ID: 465041 [Multi-domain]  Cd Length: 140  Bit Score: 37.08  E-value: 3.22e-03
                          10        20
                  ....*....|....*....|....
gi 2462623499   1 MLERAERRSYREYRPYETERQADF 24
Cdd:pfam16174 117 RRERGERRPFRERRNEEDNRQGEF 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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