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Conserved domains on  [gi|2462621636|ref|XP_054217484|]
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fibrocystin-L isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2131-2249 2.07e-43

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 155.07  E-value: 2.07e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 2131 SWGGKSPPEEGSLVVITKGQTILLDQSTPILKMLLIQgGTLIF-DEADIELQAENILITdGGVLQIGTETSPFQHKAVIT 2209
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFdDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2462621636 2210 LHG--HLRSPELPVYGAKTLAVRE-GILDLHGVPVPVTWTRLA 2249
Cdd:pfam10162   79 LHGrpELDDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKLA 121
Cupredoxin_Fibrocystin-L_like cd04217
Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease ...
 1395-1498 5.32e-36

Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease protein; One member of this family is Fibrocystin-L, a homolog of the autosomal recessive polycystic kidney disease protein PKHD1. Human fibrocystin-L is predicted to be a large receptor protein (466 kDa) with a signal peptide, a single transmembrane domain and a short cytoplasmic tail. Fibrocystin-L is widely expressed at a low level in most tissues but is up-regulated specifically in T lymphocytes following activation signals. It may play roles in immunity.


:

Pssm-ID: 259879 [Multi-domain]  Cd Length: 86  Bit Score: 132.68  E-value: 5.32e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1395 TNNGKDSVHGLGYAWSPPVLNVSVGDTVAWHWQTHPflrgiGYRIFSVSSPGSVIYDgkgftsgrQKSTSGSFSYQFTSP 1474
Cdd:cd04217      1 TNAGKDLVRGLGYVISPSELEINVGDTVTWHNFKRP-----KGRIVLVSEEGLFEDQ--------TLYYGKAFSYTFTEP 67

                           90       100
                   ....*....|....*....|....
gi 2462621636 1475 GIHYYSSGYVDEahsifLQGVINV 1498
Cdd:cd04217     68 GTYYFSVKDVPE-----MKGTINV 86
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2990-3119 5.00e-35

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 131.19  E-value: 5.00e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 2990 NNYTVPHPGANVIIPEGTWIVADIDMPSMERLIIWGVLELEDKynvgaaessyREVVLNATYISLQGGRLIGGWEDNPFK 3069
Cdd:pfam10162    3 GGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDD----------KNITLRARYILVQGGRLIIGSEDCPFQ 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462621636 3070 GDLKIVLRGNHTTQDwalPEGPNQGAKVLGV--FGELDLHGIPHSIYKTKLS 3119
Cdd:pfam10162   73 GKATITLHGRPELDD---DDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 271-363 1.05e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 83.66  E-value: 1.05e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  271 EVTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKTPPKPhilkTVYPGGRGLKLEVWNNS 350
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAA----TPGEGPVEVTVDGANVS 77

                           90
                   ....*....|...
gi 2462621636  351 RPIRLEEILEYNE 363
Cdd:cd00603     78 ARVLSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 2037-2124 2.05e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.89  E-value: 2.05e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 2037 PLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDAHTLSGWAP--VCVHIRGVGMAK 2114
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPveVTVDGANVSARV 80

                           90
                   ....*....|
gi 2462621636 2115 LDNADFLYVD 2124
Cdd:cd00603     81 LSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1659-1745 3.31e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 79.42  E-value: 3.31e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1659 PNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQ---QLVDVDLLIHGVPAQC 1735
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATpgeGPVEVTVDGANVSARV 80

                           90
                   ....*....|
gi 2462621636 1736 QGNCTFSYLE 1745
Cdd:cd00603     81 LSNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1831-1910 1.78e-16

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 77.10  E-value: 1.78e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1831 PPVASLSPTSGSIGGGTTLVITGNGFYPG--NTTVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKIFVNT--IAYPPL 1906
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDssDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGggISSSPL 80


                   ....
gi 2462621636 1907 LFTY 1910
Cdd:pfam01833   81 TFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1240-1314 1.18e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 74.80  E-value: 1.18e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462621636 1240 PIITDFSPKVRTILGEVNLTIKGYNFGNElTQNMAVYVGGKTCQILHWNFTDIRCLLPKL-SPGKHDIYVEVRNWG 1314
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSG-SPRVRVTVGGVPCKVLNVSSTEIVCRTPAAaTPGEGPVEVTVDGAN 75
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1157-1234 2.54e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 70.95  E-value: 2.54e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1157 ISHIWPDSGSIAGGTLLTLSGFGFN---ENSKVLVGNETCNVIEGDLNRITCRTPKKTEG-----TVDISVTTNGFQATA 1228
Cdd:cd00603      3 ITSISPSSGPLSGGTRLTITGSNLGsgsPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPgegpvEVTVDGANVSARVLS 82


                   ....*.
gi 2462621636 1229 RDAFSY 1234
Cdd:cd00603     83 NTTFTY 88
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1067-1154 3.91e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 64.78  E-value: 3.91e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1067 PLVLAISPSQGSYEEGTILTIVGSGFSPSSA-VTVSVGPVGCSLLSVDEKELKCQIL-NGSAGHAPVAVSmADVGLAQNV 1144
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrVRVTVGGVPCKVLNVSSTEIVCRTPaAATPGEGPVEVT-VDGANVSAR 79

                           90
                   ....*....|
gi 2462621636 1145 GGEEFYFVYQ 1154
Cdd:cd00603     80 VLSNTTFTYV 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1566-1633 5.96e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 61.31  E-value: 5.96e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1566 PSISNITPSTGTVN--ELITIIGHGFSNLPWANKVTIGSYPCVVEESSEDSITCHIDPQNSMDVGIRETV 1633
Cdd:pfam01833    1 PVITSISPSSGPASggTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTV 70
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1330-1406 2.29e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.77  E-value: 2.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1330 LEVTSMFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNVTSSSENVIKCIL--HSTGNI-FRITNNGKDSVHGLG 1406
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTppGTSGLVnVSVTVGGGGISSSPL 80
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 31-139 4.84e-10

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 59.01  E-value: 4.84e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636   31 PKVTEIIPKYGSINGATRLTIRGEGFSQanqfnygvdnselgNSVQLISSFQSITCDVEKdaSHSTQITCYTRAMPE-DS 109
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGS--------------GSPRVRVTVGGVPCKVLN--VSSTEIVCRTPAAATpGE 64

                           90       100       110
                   ....*....|....*....|....*....|
gi 2462621636  110 YTVRVSVDGVPVtenntckGHINSWECTFN 139
Cdd:cd00603     65 GPVEVTVDGANV-------SARVLSNTTFT 87
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1916-2031 2.11e-07

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 51.30  E-value: 2.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1916 PFLRGIIPSRGPP--GTEIEITGSNFgfeileisvminniqwsfgggqtmtvtgtGFNPQNSIILVCGSECAIdrLRSDY 1993
Cdd:cd00603      1 PVITSISPSSGPLsgGTRLTITGSNL-----------------------------GSGSPRVRVTVGGVPCKV--LNVSS 49

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2462621636 1994 TTLLCEIPS-NNGTGAEQACEVSVVNGKDLSQSMTPFTY 2031
Cdd:cd00603     50 TEIVCRTPAaATPGEGPVEVTVDGANVSARVLSNTTFTY 88
PA14 super family cl08459
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 341-467 9.09e-07

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


The actual alignment was detected with superfamily member smart00758:

Pssm-ID: 471833 [Multi-domain]  Cd Length: 136  Bit Score: 50.86  E-value: 9.09e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636   341 GLKLEVWNNSRPIRLEEIleynEKTPGYMGASWvDSASYIWLMEQDTFVARFSGFLVAPDSDVYRFYIKGDDRYAIYFSq 420
Cdd:smart00758    2 GLTGYYFENEKFSGLPEI----IDTDPLNTFYW-DSDKFGEGEKADNFSVRWTGYLKPPEDGEYTFSITSDDGARLWID- 75

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*..
gi 2462621636   421 tglpeDKVRIAYHSANANsyfssPTQRSDDIHLQKGKEYYIEILLQE 467
Cdd:smart00758   76 -----GKLVIDNWGKHEA-----RPSTSSTLYLLAGGTYPIRIEYFE 112
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 146-255 3.67e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 47.83  E-value: 3.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  146 PTIRSITPLSGTP--GTLITIQGRIFtdvygsnialssnGKNVRILRVYIGGMPCELlIPQSDNlyglkldhpngdmgSM 223
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNF-------------GTDSSDLKVTIGGTPCTV-ISVSST--------------TI 52

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462621636  224 VCKTTGTFIGHHNVSFILDNDYGRSFPQKMAY 255
Cdd:pfam01833   53 VCTTPPGTSGLVNVSVTVGGGGISSSPLTFTY 84
NosD super family cl34609
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 3202-3458 5.03e-05

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG3420:

Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 48.76  E-value: 5.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 3202 ILSRNIKIVGEDYPgwsedsfgarVLVGSFTENMMTFKG-NARISNVEFYHSGqegfRDSTDPRYAvtflnlgqIQEHGS 3280
Cdd:COG3420     49 VIDKPLTLIGEGGA----------VIDGGGKGTVITITAdNVTVRGLTITGSG----DSLTDDDAG--------IYVRGA 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 3281 SY--IRGCAFHHGFSpAIGVFGTDGLDIDDNIIH------FTVGEGIRIWG-NANRVRGNLIalsvwpgtYQNRKdlsst 3351
Cdd:COG3420    107 DNavIENNRIENNLF-GIYLEGSDNNVIRNNTISgnrdlrADRGNGIHLWNsPGNVIEGNTI--------SGGRD----- 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 3352 lwhaAIEINRGTNTVLQNNVVAGfGRAGYRIDGepcpGQFNPVEkwfDNEAHGGLYGIY-MNQDGLpgcsLIQGFTIWTC 3430
Cdd:COG3420    173 ----GIYLEFSDNNVIRNNTIRN-LRYGIHYMY----SNDNLVE---GNTFRDNGAGIAlMYSKGN----TVRGNTILGN 236

                          250       260
                   ....*....|....*....|....*...
gi 2462621636 3431 WDYGIYFQTTESVHIYNVTLVDNGMAIF 3458
Cdd:COG3420    237 SGYGILLKESSDSVIEGNTISGNGKGIF 264
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1749-1827 1.63e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 43.20  E-value: 1.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1749 PYITGVFPNS--VIGSVKVLIEGEGLGTVLEDIAVFIGNQQFRAIEVNENNITALVTPLPVGHHSVSVVVGSKGLALGNL 1826
Cdd:pfam01833    1 PVITSISPSSgpASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   .
gi 2462621636 1827 T 1827
Cdd:pfam01833   81 T 81
 
Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2131-2249 2.07e-43

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 155.07  E-value: 2.07e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 2131 SWGGKSPPEEGSLVVITKGQTILLDQSTPILKMLLIQgGTLIF-DEADIELQAENILITdGGVLQIGTETSPFQHKAVIT 2209
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFdDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2462621636 2210 LHG--HLRSPELPVYGAKTLAVRE-GILDLHGVPVPVTWTRLA 2249
Cdd:pfam10162   79 LHGrpELDDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKLA 121
Cupredoxin_Fibrocystin-L_like cd04217
Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease ...
 1395-1498 5.32e-36

Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease protein; One member of this family is Fibrocystin-L, a homolog of the autosomal recessive polycystic kidney disease protein PKHD1. Human fibrocystin-L is predicted to be a large receptor protein (466 kDa) with a signal peptide, a single transmembrane domain and a short cytoplasmic tail. Fibrocystin-L is widely expressed at a low level in most tissues but is up-regulated specifically in T lymphocytes following activation signals. It may play roles in immunity.


Pssm-ID: 259879 [Multi-domain]  Cd Length: 86  Bit Score: 132.68  E-value: 5.32e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1395 TNNGKDSVHGLGYAWSPPVLNVSVGDTVAWHWQTHPflrgiGYRIFSVSSPGSVIYDgkgftsgrQKSTSGSFSYQFTSP 1474
Cdd:cd04217      1 TNAGKDLVRGLGYVISPSELEINVGDTVTWHNFKRP-----KGRIVLVSEEGLFEDQ--------TLYYGKAFSYTFTEP 67

                           90       100
                   ....*....|....*....|....
gi 2462621636 1475 GIHYYSSGYVDEahsifLQGVINV 1498
Cdd:cd04217     68 GTYYFSVKDVPE-----MKGTINV 86
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2990-3119 5.00e-35

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 131.19  E-value: 5.00e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 2990 NNYTVPHPGANVIIPEGTWIVADIDMPSMERLIIWGVLELEDKynvgaaessyREVVLNATYISLQGGRLIGGWEDNPFK 3069
Cdd:pfam10162    3 GGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDD----------KNITLRARYILVQGGRLIIGSEDCPFQ 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462621636 3070 GDLKIVLRGNHTTQDwalPEGPNQGAKVLGV--FGELDLHGIPHSIYKTKLS 3119
Cdd:pfam10162   73 GKATITLHGRPELDD---DDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 271-363 1.05e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 83.66  E-value: 1.05e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  271 EVTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKTPPKPhilkTVYPGGRGLKLEVWNNS 350
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAA----TPGEGPVEVTVDGANVS 77

                           90
                   ....*....|...
gi 2462621636  351 RPIRLEEILEYNE 363
Cdd:cd00603     78 ARVLSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 2037-2124 2.05e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.89  E-value: 2.05e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 2037 PLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDAHTLSGWAP--VCVHIRGVGMAK 2114
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPveVTVDGANVSARV 80

                           90
                   ....*....|
gi 2462621636 2115 LDNADFLYVD 2124
Cdd:cd00603     81 LSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1659-1745 3.31e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 79.42  E-value: 3.31e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1659 PNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQ---QLVDVDLLIHGVPAQC 1735
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATpgeGPVEVTVDGANVSARV 80

                           90
                   ....*....|
gi 2462621636 1736 QGNCTFSYLE 1745
Cdd:cd00603     81 LSNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1831-1910 1.78e-16

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 77.10  E-value: 1.78e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1831 PPVASLSPTSGSIGGGTTLVITGNGFYPG--NTTVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKIFVNT--IAYPPL 1906
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDssDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGggISSSPL 80


                   ....
gi 2462621636 1907 LFTY 1910
Cdd:pfam01833   81 TFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1831-1910 1.91e-16

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 77.11  E-value: 1.91e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1831 PPVASLSPTSGSIGGGTTLVITGNGFYPG--NTTVTIGDEPCQIISINPNEVYCRTPAGTTGM---VDVKIF---VNTIA 1902
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGspRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGegpVEVTVDganVSARV 80


                   ....*...
gi 2462621636 1903 YPPLLFTY 1910
Cdd:cd00603     81 LSNTTFTY 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 2037-2122 5.84e-16

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 75.56  E-value: 5.84e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 2037 PLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDAHTlSGWAPVCVHIRGVGMAkLD 2116
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGT-SGLVNVSVTVGGGGIS-SS 78


                   ....*.
gi 2462621636 2117 NADFLY 2122
Cdd:pfam01833   79 PLTFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1240-1314 1.18e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 74.80  E-value: 1.18e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462621636 1240 PIITDFSPKVRTILGEVNLTIKGYNFGNElTQNMAVYVGGKTCQILHWNFTDIRCLLPKL-SPGKHDIYVEVRNWG 1314
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSG-SPRVRVTVGGVPCKVLNVSSTEIVCRTPAAaTPGEGPVEVTVDGAN 75
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1157-1234 2.54e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 70.95  E-value: 2.54e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1157 ISHIWPDSGSIAGGTLLTLSGFGFN---ENSKVLVGNETCNVIEGDLNRITCRTPKKTEG-----TVDISVTTNGFQATA 1228
Cdd:cd00603      3 ITSISPSSGPLSGGTRLTITGSNLGsgsPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPgegpvEVTVDGANVSARVLS 82


                   ....*.
gi 2462621636 1229 RDAFSY 1234
Cdd:cd00603     83 NTTFTY 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1659-1743 1.17e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 66.32  E-value: 1.17e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1659 PNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQQLVDVDLLIHGVpAQCQGN 1738
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGG-GISSSP 79


                   ....*
gi 2462621636 1739 CTFSY 1743
Cdd:pfam01833   80 LTFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1067-1154 3.91e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 64.78  E-value: 3.91e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1067 PLVLAISPSQGSYEEGTILTIVGSGFSPSSA-VTVSVGPVGCSLLSVDEKELKCQIL-NGSAGHAPVAVSmADVGLAQNV 1144
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrVRVTVGGVPCKVLNVSSTEIVCRTPaAATPGEGPVEVT-VDGANVSAR 79

                           90
                   ....*....|
gi 2462621636 1145 GGEEFYFVYQ 1154
Cdd:cd00603     80 VLSNTTFTYV 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1156-1234 1.48e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 62.85  E-value: 1.48e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1156 QISHIWPDSGSIAGGTLLTLSGFGFNENS---KVLVGNETCNVIEGDLNRITCRTPKKTEGTVDISVTTNGFQATARD-A 1231
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSNFGTDSsdlKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPlT 81


                   ...
gi 2462621636 1232 FSY 1234
Cdd:pfam01833   82 FTY 84
IPT smart00429
ig-like, plexins, transcription factors;
271-335 4.33e-11

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 62.05  E-value: 4.33e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462621636   271 EVTMIFPSQGSIRGGTTLTISGRFFDQ-TDFPVRVLVGGEPCDILNVTENSICCKTPPKPHILKTV 335
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLKSiSVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSV 68
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1566-1633 5.96e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 61.31  E-value: 5.96e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1566 PSISNITPSTGTVN--ELITIIGHGFSNLPWANKVTIGSYPCVVEESSEDSITCHIDPQNSMDVGIRETV 1633
Cdd:pfam01833    1 PVITSISPSSGPASggTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTV 70
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1330-1406 2.29e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.77  E-value: 2.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1330 LEVTSMFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNVTSSSENVIKCIL--HSTGNI-FRITNNGKDSVHGLG 1406
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTppGTSGLVnVSVTVGGGGISSSPL 80
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1331-1383 3.06e-10

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 59.39  E-value: 3.06e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462621636 1331 EVTSMFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNVTSSSENVIKC 1383
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVC 54
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 272-327 3.66e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.00  E-value: 3.66e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462621636  272 VTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKTPP 327
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPP 58
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 31-139 4.84e-10

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 59.01  E-value: 4.84e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636   31 PKVTEIIPKYGSINGATRLTIRGEGFSQanqfnygvdnselgNSVQLISSFQSITCDVEKdaSHSTQITCYTRAMPE-DS 109
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGS--------------GSPRVRVTVGGVPCKVLN--VSSTEIVCRTPAAATpGE 64

                           90       100       110
                   ....*....|....*....|....*....|
gi 2462621636  110 YTVRVSVDGVPVtenntckGHINSWECTFN 139
Cdd:cd00603     65 GPVEVTVDGANV-------SARVLSNTTFT 87
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1240-1318 2.53e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 56.69  E-value: 2.53e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462621636 1240 PIITDFSPKVRTILGEVNLTIKGYNFGNElTQNMAVYVGGKTCQILHWNFTDIRCLLPKLSPGKHDIYVEVRNWGFAST 1318
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTD-SSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1067-1143 5.01e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.92  E-value: 5.01e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462621636 1067 PLVLAISPSQGSYEEGTILTIVGSGFSP-SSAVTVSVGPVGCSLLSVDEKELKCQILNGSAGHAPVAVSMADVGLAQN 1143
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTdSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
IPT smart00429
ig-like, plexins, transcription factors;
1831-1896 9.61e-09

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 55.12  E-value: 9.61e-09
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462621636  1831 PPVASLSPTSGSIGGGTTLVITGNGFYPGNT---TVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKI 1896
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVvfvEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPV 70
IPT smart00429
ig-like, plexins, transcription factors;
1157-1225 6.44e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 52.81  E-value: 6.44e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462621636  1157 ISHIWPDSGSIAGGTLLTLSGFGFN----ENSKVLVGNETCNVIEGDLNRITCRTPKKTEGTVDISVTTNGFQ 1225
Cdd:smart00429    4 ITRISPTSGPVSGGTEITLCGKNLKsisvVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLR 76
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1916-2031 2.11e-07

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 51.30  E-value: 2.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1916 PFLRGIIPSRGPP--GTEIEITGSNFgfeileisvminniqwsfgggqtmtvtgtGFNPQNSIILVCGSECAIdrLRSDY 1993
Cdd:cd00603      1 PVITSISPSSGPLsgGTRLTITGSNL-----------------------------GSGSPRVRVTVGGVPCKV--LNVSS 49

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2462621636 1994 TTLLCEIPS-NNGTGAEQACEVSVVNGKDLSQSMTPFTY 2031
Cdd:cd00603     50 TEIVCRTPAaATPGEGPVEVTVDGANVSARVLSNTTFTY 88
IPT smart00429
ig-like, plexins, transcription factors;
2037-2123 6.14e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 50.11  E-value: 6.14e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  2037 PLITAVSPKRGSTAGGTRLTVVGSGF-SENMEDVHITIAEAKCDVEYSNKTHIICMTDA-HTLSGWAPV-CVHIRGVGmA 2113
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLkSISVVFVEVGVGEAPCTFSPSSSTAIVCKTPPyHNIPGSVPVrTVGLRNGG-V 80

                            90
                    ....*....|
gi 2462621636  2114 KLDNADFLYV 2123
Cdd:smart00429   81 PSSPQPFTYV 90
PA14 smart00758
domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, ...
 341-467 9.09e-07

domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins;


Pssm-ID: 214807 [Multi-domain]  Cd Length: 136  Bit Score: 50.86  E-value: 9.09e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636   341 GLKLEVWNNSRPIRLEEIleynEKTPGYMGASWvDSASYIWLMEQDTFVARFSGFLVAPDSDVYRFYIKGDDRYAIYFSq 420
Cdd:smart00758    2 GLTGYYFENEKFSGLPEI----IDTDPLNTFYW-DSDKFGEGEKADNFSVRWTGYLKPPEDGEYTFSITSDDGARLWID- 75

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*..
gi 2462621636   421 tglpeDKVRIAYHSANANsyfssPTQRSDDIHLQKGKEYYIEILLQE 467
Cdd:smart00758   76 -----GKLVIDNWGKHEA-----RPSTSSTLYLLAGGTYPIRIEYFE 112
IPT smart00429
ig-like, plexins, transcription factors;
1067-1153 2.46e-06

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 48.57  E-value: 2.46e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  1067 PLVLAISPSQGSYEEGTILTIVGSGFSPSSAVTVSVGPVG--CSLLSVDEKELKCQILNGSAGHAPVAVSMADVGLAqNV 1144
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEapCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLRNG-GV 80


                    ....*....
gi 2462621636  1145 GGEEFYFVY 1153
Cdd:smart00429   81 PSSPQPFTY 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 146-255 3.67e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 47.83  E-value: 3.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  146 PTIRSITPLSGTP--GTLITIQGRIFtdvygsnialssnGKNVRILRVYIGGMPCELlIPQSDNlyglkldhpngdmgSM 223
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNF-------------GTDSSDLKVTIGGTPCTV-ISVSST--------------TI 52

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462621636  224 VCKTTGTFIGHHNVSFILDNDYGRSFPQKMAY 255
Cdd:pfam01833   53 VCTTPPGTSGLVNVSVTVGGGGISSSPLTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1956-2031 5.06e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 47.44  E-value: 5.06e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462621636 1956 SFGGGQTMTVTGTGFN--PQNSIILVCGSECAIdrLRSDYTTLLCEIPSNNGTGaeqaCEVSV-VNGKDLSQSMTPFTY 2031
Cdd:pfam01833   12 PASGGTTITITGSNFGtdSSDLKVTIGGTPCTV--ISVSSTTIVCTTPPGTSGL----VNVSVtVGGGGISSSPLTFTY 84
PA14 pfam07691
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 363-467 5.22e-06

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


Pssm-ID: 400161 [Multi-domain]  Cd Length: 141  Bit Score: 48.90  E-value: 5.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  363 EKTPGYMGASWvDSASYIWLMEQDTFVARFSGFLVAPDSDVYRFYIKGDDRYAIYFSqtglpeDKVRIAYhsaNANSYFS 442
Cdd:pfam07691   22 IDTDPDNTFYW-DTDVPGFGEAPGDFSARWTGYLLPPESGTYTFGVASDDGARLWID------GELVIDN---WGQHPPD 91

                           90       100
                   ....*....|....*....|....*
gi 2462621636  443 SPTQRSDDIHLQKGKEYYIEILLQE 467
Cdd:pfam07691   92 ASPEESNTLYLVAGKLYPIRIEYFH 116
IPT smart00429
ig-like, plexins, transcription factors;
1658-1744 5.37e-06

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 47.42  E-value: 5.37e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  1658 LPNIDLVLPNAGSTTGMTSVTIKGSGF-AVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQQLVD-----VDLLIHGV 1731
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLkSISVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSvpvrtVGLRNGGV 80

                            90
                    ....*....|...
gi 2462621636  1732 PAQCQgncTFSYL 1744
Cdd:smart00429   81 PSSPQ---PFTYV 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1566-1624 1.42e-05

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 46.29  E-value: 1.42e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462621636 1566 PSISNITPSTGTVNE--LITIIGHGFSNLPWANKVTIGSYPCVVEESSEDSITCHIDPQNS 1624
Cdd:cd00603      1 PVITSISPSSGPLSGgtRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAT 61
IPT smart00429
ig-like, plexins, transcription factors;
1330-1383 1.59e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 46.26  E-value: 1.59e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 2462621636  1330 LEVTSMFPQRGSLFGGTEITIRGFGFSTIPAEN-TVLLGSIPCNVTSSSENVIKC 1383
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFvEVGVGEAPCTFSPSSSTAIVC 56
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 31-126 2.78e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 45.13  E-value: 2.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636   31 PKVTEIIPKYGSINGATRLTIRGEGFSQanqfnygvdnselgNSVQLISSFQSITCDVEKDAshSTQITCYTRAMPEDSY 110
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGT--------------DSSDLKVTIGGTPCTVISVS--STTIVCTTPPGTSGLV 64

                           90
                   ....*....|....*.
gi 2462621636  111 TVRVSVDGVPVTENNT 126
Cdd:pfam01833   65 NVSVTVGGGGISSSPL 80
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 3202-3458 5.03e-05

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 48.76  E-value: 5.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 3202 ILSRNIKIVGEDYPgwsedsfgarVLVGSFTENMMTFKG-NARISNVEFYHSGqegfRDSTDPRYAvtflnlgqIQEHGS 3280
Cdd:COG3420     49 VIDKPLTLIGEGGA----------VIDGGGKGTVITITAdNVTVRGLTITGSG----DSLTDDDAG--------IYVRGA 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 3281 SY--IRGCAFHHGFSpAIGVFGTDGLDIDDNIIH------FTVGEGIRIWG-NANRVRGNLIalsvwpgtYQNRKdlsst 3351
Cdd:COG3420    107 DNavIENNRIENNLF-GIYLEGSDNNVIRNNTISgnrdlrADRGNGIHLWNsPGNVIEGNTI--------SGGRD----- 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 3352 lwhaAIEINRGTNTVLQNNVVAGfGRAGYRIDGepcpGQFNPVEkwfDNEAHGGLYGIY-MNQDGLpgcsLIQGFTIWTC 3430
Cdd:COG3420    173 ----GIYLEFSDNNVIRNNTIRN-LRYGIHYMY----SNDNLVE---GNTFRDNGAGIAlMYSKGN----TVRGNTILGN 236

                          250       260
                   ....*....|....*....|....*...
gi 2462621636 3431 WDYGIYFQTTESVHIYNVTLVDNGMAIF 3458
Cdd:COG3420    237 SGYGILLKESSDSVIEGNTISGNGKGIF 264
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 146-244 9.82e-05

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 43.98  E-value: 9.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  146 PTIRSITPLSGTP--GTLITIqgriftdvYGSNiaLSSNGKNVRilrVYIGGMPCELLipqsdnlyglkldhpNGDMGSM 223
Cdd:cd00603      1 PVITSISPSSGPLsgGTRLTI--------TGSN--LGSGSPRVR---VTVGGVPCKVL---------------NVSSTEI 52

                           90       100
                   ....*....|....*....|..
gi 2462621636  224 VCKT-TGTFIGHHNVSFILDND 244
Cdd:cd00603     53 VCRTpAAATPGEGPVEVTVDGA 74
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1749-1827 1.63e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 43.20  E-value: 1.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1749 PYITGVFPNS--VIGSVKVLIEGEGLGTVLEDIAVFIGNQQFRAIEVNENNITALVTPLPVGHHSVSVVVGSKGLALGNL 1826
Cdd:pfam01833    1 PVITSISPSSgpASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   .
gi 2462621636 1827 T 1827
Cdd:pfam01833   81 T 81
IPT smart00429
ig-like, plexins, transcription factors;
31-138 1.82e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 43.18  E-value: 1.82e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636    31 PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNSElgnsvqlissfqsITCDVekDASHSTQITCYTRAmpedsy 110
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGE-------------APCTF--SPSSSTAIVCKTPP------ 60

                            90       100
                    ....*....|....*....|....*...
gi 2462621636   111 tVRVSVDGVPVTENNTCKGHINSWECTF 138
Cdd:smart00429   61 -YHNIPGSVPVRTVGLRNGGVPSSPQPF 87
PetE COG3794
Plastocyanin [Energy production and conversion];
1407-1479 2.51e-04

Plastocyanin [Energy production and conversion];


Pssm-ID: 443008 [Multi-domain]  Cd Length: 76  Bit Score: 42.29  E-value: 2.51e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462621636 1407 YAWSPPVLNVSVGDTVAWHWQThpflrGIGYRIFSVSSPgsviydGKGFTSGRQKsTSGSFSYQFTSPGIHYY 1479
Cdd:COG3794      1 MAFEPATLTVKPGDTVTWVNTD-----SVPHNVTSDDGP------DGAFDSGLLA-PGETFSVTFDEPGTYDY 61
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 3240-3333 7.61e-03

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 40.08  E-value: 7.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 3240 GNARISNVEFYHSGQEGFRDSTDPRyaVTFLN-------LGQIQEHGSSY--IRGCAFHHGFSPAIGVFGTDGLDIDDNI 3310
Cdd:pfam13229   32 SNATIENNTITNNGGDGIEISGSSN--NTISNntisnngGGGIALRGSSNnlIENNTISNNGGAGIYLSDSSNNTIENNI 109

                           90       100
                   ....*....|....*....|....*
gi 2462621636 3311 IHFTVGEGIRI--WGNANRVRGNLI 3333
Cdd:pfam13229  110 IHNNGGSGIVIedSSNNVTISNNTV 134
IPT smart00429
ig-like, plexins, transcription factors;
1921-2031 8.09e-03

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 38.56  E-value: 8.09e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  1921 IIPSRGPP--GTEIEITGSNFGFeileisvmINNIQWSFGGGqtmtvtgtgfnpqnsiilvcGSECAIDRLRSdyTTLLC 1998
Cdd:smart00429    7 ISPTSGPVsgGTEITLCGKNLKS--------ISVVFVEVGVG--------------------EAPCTFSPSSS--TAIVC 56

                            90       100       110
                    ....*....|....*....|....*....|....
gi 2462621636  1999 EIPS-NNGTGAEQACEVSVVNGkDLSQSMTPFTY 2031
Cdd:smart00429   57 KTPPyHNIPGSVPVRTVGLRNG-GVPSSPQPFTY 89
IPT smart00429
ig-like, plexins, transcription factors;
1240-1297 8.83e-03

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 38.17  E-value: 8.83e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462621636  1240 PIITDFSPKVRTILGEVNLTIKGYNFGNELTQNMAVYVGGKTCQILHWNFTDIRCLLP 1297
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAPCTFSPSSSTAIVCKTP 59
 
Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2131-2249 2.07e-43

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 155.07  E-value: 2.07e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 2131 SWGGKSPPEEGSLVVITKGQTILLDQSTPILKMLLIQgGTLIF-DEADIELQAENILITdGGVLQIGTETSPFQHKAVIT 2209
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQ-GTLIFdDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2462621636 2210 LHG--HLRSPELPVYGAKTLAVRE-GILDLHGVPVPVTWTRLA 2249
Cdd:pfam10162   79 LHGrpELDDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKLA 121
Cupredoxin_Fibrocystin-L_like cd04217
Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease ...
 1395-1498 5.32e-36

Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease protein; One member of this family is Fibrocystin-L, a homolog of the autosomal recessive polycystic kidney disease protein PKHD1. Human fibrocystin-L is predicted to be a large receptor protein (466 kDa) with a signal peptide, a single transmembrane domain and a short cytoplasmic tail. Fibrocystin-L is widely expressed at a low level in most tissues but is up-regulated specifically in T lymphocytes following activation signals. It may play roles in immunity.


Pssm-ID: 259879 [Multi-domain]  Cd Length: 86  Bit Score: 132.68  E-value: 5.32e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1395 TNNGKDSVHGLGYAWSPPVLNVSVGDTVAWHWQTHPflrgiGYRIFSVSSPGSVIYDgkgftsgrQKSTSGSFSYQFTSP 1474
Cdd:cd04217      1 TNAGKDLVRGLGYVISPSELEINVGDTVTWHNFKRP-----KGRIVLVSEEGLFEDQ--------TLYYGKAFSYTFTEP 67

                           90       100
                   ....*....|....*....|....
gi 2462621636 1475 GIHYYSSGYVDEahsifLQGVINV 1498
Cdd:cd04217     68 GTYYFSVKDVPE-----MKGTINV 86
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2990-3119 5.00e-35

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 131.19  E-value: 5.00e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 2990 NNYTVPHPGANVIIPEGTWIVADIDMPSMERLIIWGVLELEDKynvgaaessyREVVLNATYISLQGGRLIGGWEDNPFK 3069
Cdd:pfam10162    3 GGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDD----------KNITLRARYILVQGGRLIIGSEDCPFQ 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462621636 3070 GDLKIVLRGNHTTQDwalPEGPNQGAKVLGV--FGELDLHGIPHSIYKTKLS 3119
Cdd:pfam10162   73 GKATITLHGRPELDD---DDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKLA 121
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 271-363 1.05e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 83.66  E-value: 1.05e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  271 EVTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKTPPKPhilkTVYPGGRGLKLEVWNNS 350
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAA----TPGEGPVEVTVDGANVS 77

                           90
                   ....*....|...
gi 2462621636  351 RPIRLEEILEYNE 363
Cdd:cd00603     78 ARVLSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 2037-2124 2.05e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.89  E-value: 2.05e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 2037 PLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDAHTLSGWAP--VCVHIRGVGMAK 2114
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPveVTVDGANVSARV 80

                           90
                   ....*....|
gi 2462621636 2115 LDNADFLYVD 2124
Cdd:cd00603     81 LSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1659-1745 3.31e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 79.42  E-value: 3.31e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1659 PNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQ---QLVDVDLLIHGVPAQC 1735
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATpgeGPVEVTVDGANVSARV 80

                           90
                   ....*....|
gi 2462621636 1736 QGNCTFSYLE 1745
Cdd:cd00603     81 LSNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1831-1910 1.78e-16

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 77.10  E-value: 1.78e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1831 PPVASLSPTSGSIGGGTTLVITGNGFYPG--NTTVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKIFVNT--IAYPPL 1906
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDssDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGggISSSPL 80


                   ....
gi 2462621636 1907 LFTY 1910
Cdd:pfam01833   81 TFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1831-1910 1.91e-16

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 77.11  E-value: 1.91e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1831 PPVASLSPTSGSIGGGTTLVITGNGFYPG--NTTVTIGDEPCQIISINPNEVYCRTPAGTTGM---VDVKIF---VNTIA 1902
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGspRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGegpVEVTVDganVSARV 80


                   ....*...
gi 2462621636 1903 YPPLLFTY 1910
Cdd:cd00603     81 LSNTTFTY 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 2037-2122 5.84e-16

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 75.56  E-value: 5.84e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 2037 PLITAVSPKRGSTAGGTRLTVVGSGFSENMEDVHITIAEAKCDVEYSNKTHIICMTDAHTlSGWAPVCVHIRGVGMAkLD 2116
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGT-SGLVNVSVTVGGGGIS-SS 78


                   ....*.
gi 2462621636 2117 NADFLY 2122
Cdd:pfam01833   79 PLTFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1240-1314 1.18e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 74.80  E-value: 1.18e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462621636 1240 PIITDFSPKVRTILGEVNLTIKGYNFGNElTQNMAVYVGGKTCQILHWNFTDIRCLLPKL-SPGKHDIYVEVRNWG 1314
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSG-SPRVRVTVGGVPCKVLNVSSTEIVCRTPAAaTPGEGPVEVTVDGAN 75
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1831-1910 9.18e-15

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 72.49  E-value: 9.18e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1831 PPVASLSPTSGSIGGGTTLVITGNGFYPG-NTTVTIGDE-PCQIISINPNEVYCRTPAGTTGM-----VDVKIFVNTIAY 1903
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGsNLRVTFGGGvPCSVLSVSSTAIVCTTPPYANPGpgpveVTVDRGNGGITS 80


                   ....*..
gi 2462621636 1904 PPLLFTY 1910
Cdd:cd00102     81 SPLTFTY 87
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1157-1234 2.54e-14

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 70.95  E-value: 2.54e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1157 ISHIWPDSGSIAGGTLLTLSGFGFN---ENSKVLVGNETCNVIEGDLNRITCRTPKKTEG-----TVDISVTTNGFQATA 1228
Cdd:cd00603      3 ITSISPSSGPLSGGTRLTITGSNLGsgsPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPgegpvEVTVDGANVSARVLS 82


                   ....*.
gi 2462621636 1229 RDAFSY 1234
Cdd:cd00603     83 NTTFTY 88
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 2037-2124 2.92e-13

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 67.87  E-value: 2.92e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 2037 PLITAVSPKRGSTAGGTRLTVVGSGFSENMeDVHITI-AEAKCDVEYSNKTHIICMTDAHTLSGWAPVCVHI-RGVGMAK 2114
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGS-NLRVTFgGGVPCSVLSVSSTAIVCTTPPYANPGPGPVEVTVdRGNGGIT 79

                           90
                   ....*....|
gi 2462621636 2115 LDNADFLYVD 2124
Cdd:cd00102     80 SSPLTFTYVP 89
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 271-329 5.72e-13

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 67.10  E-value: 5.72e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  271 EVTMIFPSQGSIRGGTTLTISGRFFDqTDFPVRVLVGGE-PCDILNVTENSICCKTPPKP 329
Cdd:cd00102      2 VITSISPSSGPVSGGTEVTITGSNFG-SGSNLRVTFGGGvPCSVLSVSSTAIVCTTPPYA 60
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1659-1743 1.17e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 66.32  E-value: 1.17e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1659 PNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQQLVDVDLLIHGVpAQCQGN 1738
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGG-GISSSP 79


                   ....*
gi 2462621636 1739 CTFSY 1743
Cdd:pfam01833   80 LTFTY 84
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 272-363 1.21e-12

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 66.09  E-value: 1.21e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  272 VTMIFPSQGSIRGGTTLTISGRFFDqTDFPVRVLVGGEPCDILNVTENSICCKTPPKPHILKtvypggrgLKLEVWNNSR 351
Cdd:cd01179      3 ITSLSPSYGPQSGGTRLTITGKHLN-AGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGE--------APVKVLIDGA 73

                           90
                   ....*....|..
gi 2462621636  352 PIRLEEILEYNE 363
Cdd:cd01179     74 RRLAPLVFTYTE 85
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1831-1910 1.50e-12

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 65.71  E-value: 1.50e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1831 PPVASLSPTSGSIGGGTTLVITGNGFYPGNTT-VTIGDEPCQIISINPNEVYCRTPAGTTGM-VDVKIFV-NTIAYPPLL 1907
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVrVTVGGQPCKILSVSSSQIVCLTPPSASPGeAPVKVLIdGARRLAPLV 80


                   ...
gi 2462621636 1908 FTY 1910
Cdd:cd01179     81 FTY 83
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1067-1154 3.91e-12

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 64.78  E-value: 3.91e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1067 PLVLAISPSQGSYEEGTILTIVGSGFSPSSA-VTVSVGPVGCSLLSVDEKELKCQIL-NGSAGHAPVAVSmADVGLAQNV 1144
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrVRVTVGGVPCKVLNVSSTEIVCRTPaAATPGEGPVEVT-VDGANVSAR 79

                           90
                   ....*....|
gi 2462621636 1145 GGEEFYFVYQ 1154
Cdd:cd00603     80 VLSNTTFTYV 89
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1156-1234 4.06e-12

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 64.79  E-value: 4.06e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1156 QISHIWPDSGSIAGGTLLTLSG--FGFNENSKVLV-GNETCNVIEGDLNRITCRTPK---KTEGTVDISVTT-NGFQATA 1228
Cdd:cd00102      2 VITSISPSSGPVSGGTEVTITGsnFGSGSNLRVTFgGGVPCSVLSVSSTAIVCTTPPyanPGPGPVEVTVDRgNGGITSS 81


                   ....*.
gi 2462621636 1229 RDAFSY 1234
Cdd:cd00102     82 PLTFTY 87
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1156-1234 1.48e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 62.85  E-value: 1.48e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1156 QISHIWPDSGSIAGGTLLTLSGFGFNENS---KVLVGNETCNVIEGDLNRITCRTPKKTEGTVDISVTTNGFQATARD-A 1231
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSNFGTDSsdlKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPlT 81


                   ...
gi 2462621636 1232 FSY 1234
Cdd:pfam01833   82 FTY 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1659-1745 3.82e-11

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 62.09  E-value: 3.82e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1659 PNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQQL-VDVDLLIHGVPAQCQG 1737
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGGGVPCSVLSVSSTAIVCTTPPYANPGpGPVEVTVDRGNGGITS 80


                   ....*....
gi 2462621636 1738 NC-TFSYLE 1745
Cdd:cd00102     81 SPlTFTYVP 89
IPT smart00429
ig-like, plexins, transcription factors;
271-335 4.33e-11

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 62.05  E-value: 4.33e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462621636   271 EVTMIFPSQGSIRGGTTLTISGRFFDQ-TDFPVRVLVGGEPCDILNVTENSICCKTPPKPHILKTV 335
Cdd:smart00429    3 VITRISPTSGPVSGGTEITLCGKNLKSiSVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSV 68
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1566-1633 5.96e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 61.31  E-value: 5.96e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1566 PSISNITPSTGTVN--ELITIIGHGFSNLPWANKVTIGSYPCVVEESSEDSITCHIDPQNSMDVGIRETV 1633
Cdd:pfam01833    1 PVITSISPSSGPASggTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTV 70
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1330-1406 2.29e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.77  E-value: 2.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1330 LEVTSMFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNVTSSSENVIKCIL--HSTGNI-FRITNNGKDSVHGLG 1406
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTppGTSGLVnVSVTVGGGGISSSPL 80
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1331-1383 3.06e-10

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 59.39  E-value: 3.06e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462621636 1331 EVTSMFPQRGSLFGGTEITIRGFGFSTIPAENTVLLGSIPCNVTSSSENVIKC 1383
Cdd:cd00603      2 VITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVC 54
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1240-1318 3.60e-10

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 59.40  E-value: 3.60e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1240 PIITDFSPKVRTILGEVNLTIKGYNFGNEltQNMAVYVGG-KTCQILHWNFTDIRCLLPKL---SPGKHDIYVEVRNWGF 1315
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSG--SNLRVTFGGgVPCSVLSVSSTAIVCTTPPYanpGPGPVEVTVDRGNGGI 78


                   ...
gi 2462621636 1316 AST 1318
Cdd:cd00102     79 TSS 81
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 272-327 3.66e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.00  E-value: 3.66e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462621636  272 VTMIFPSQGSIRGGTTLTISGRFFDQTDFPVRVLVGGEPCDILNVTENSICCKTPP 327
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPP 58
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 31-139 4.84e-10

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 59.01  E-value: 4.84e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636   31 PKVTEIIPKYGSINGATRLTIRGEGFSQanqfnygvdnselgNSVQLISSFQSITCDVEKdaSHSTQITCYTRAMPE-DS 109
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGS--------------GSPRVRVTVGGVPCKVLN--VSSTEIVCRTPAAATpGE 64

                           90       100       110
                   ....*....|....*....|....*....|
gi 2462621636  110 YTVRVSVDGVPVtenntckGHINSWECTFN 139
Cdd:cd00603     65 GPVEVTVDGANV-------SARVLSNTTFT 87
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1067-1155 1.89e-09

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 57.09  E-value: 1.89e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1067 PLVLAISPSQGSYEEGTILTIVGSGFSPSSAVTVSV-GPVGCSLLSVDEKELKCQI---LNGSAGHAPVAVSMADVGLAQ 1142
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFgGGVPCSVLSVSSTAIVCTTppyANPGPGPVEVTVDRGNGGITS 80

                           90
                   ....*....|...
gi 2462621636 1143 NvggeEFYFVYQS 1155
Cdd:cd00102     81 S----PLTFTYVP 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1240-1318 2.53e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 56.69  E-value: 2.53e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462621636 1240 PIITDFSPKVRTILGEVNLTIKGYNFGNElTQNMAVYVGGKTCQILHWNFTDIRCLLPKLSPGKHDIYVEVRNWGFAST 1318
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTD-SSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1067-1143 5.01e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.92  E-value: 5.01e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462621636 1067 PLVLAISPSQGSYEEGTILTIVGSGFSP-SSAVTVSVGPVGCSLLSVDEKELKCQILNGSAGHAPVAVSMADVGLAQN 1143
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTdSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 2037-2107 8.46e-09

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 55.31  E-value: 8.46e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462621636 2037 PLITAVSPKRGSTAGGTRLTVVG----SGFSenmedVHITIAEAKCDVEYSNKTHIICMTDAHTLSGWAPVCVHI 2107
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGkhlnAGSS-----VRVTVGGQPCKILSVSSSQIVCLTPPSASPGEAPVKVLI 70
IPT smart00429
ig-like, plexins, transcription factors;
1831-1896 9.61e-09

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 55.12  E-value: 9.61e-09
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462621636  1831 PPVASLSPTSGSIGGGTTLVITGNGFYPGNT---TVTIGDEPCQIISINPNEVYCRTPAGTTGMVDVKI 1896
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVvfvEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPV 70
IPT smart00429
ig-like, plexins, transcription factors;
1157-1225 6.44e-08

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 52.81  E-value: 6.44e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462621636  1157 ISHIWPDSGSIAGGTLLTLSGFGFN----ENSKVLVGNETCNVIEGDLNRITCRTPKKTEGTVDISVTTNGFQ 1225
Cdd:smart00429    4 ITRISPTSGPVSGGTEITLCGKNLKsisvVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLR 76
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 2037-2124 9.84e-08

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 52.32  E-value: 9.84e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 2037 PLITAVSPKRGSTAGGTRLTVVGS--GFSENMEDVHITIAEAKCDV---EYSNKTHIICMTD-AHTLSGWAPVCVHIRGV 2110
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSnlGLRKNDVRHGVRVGGVPCNPeppEYSSSEKIVCTTGpAGNPVFNGPVEVTVGHG 80

                           90
                   ....*....|....
gi 2462621636 2111 GMAKLDNADFLYVD 2124
Cdd:cd01180     81 SFRTESSEGFSFVD 94
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1916-2031 2.11e-07

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 51.30  E-value: 2.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1916 PFLRGIIPSRGPP--GTEIEITGSNFgfeileisvminniqwsfgggqtmtvtgtGFNPQNSIILVCGSECAIdrLRSDY 1993
Cdd:cd00603      1 PVITSISPSSGPLsgGTRLTITGSNL-----------------------------GSGSPRVRVTVGGVPCKV--LNVSS 49

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 2462621636 1994 TTLLCEIPS-NNGTGAEQACEVSVVNGKDLSQSMTPFTY 2031
Cdd:cd00603     50 TEIVCRTPAaATPGEGPVEVTVDGANVSARVLSNTTFTY 88
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 31-128 2.15e-07

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 51.31  E-value: 2.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636   31 PKVTEIIPKYGSINGATRLTIRGEGFSQANqfnygvdnselgNSVQLIssFQSITCDVEKdaSHSTQITCYTRAMPE-DS 109
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGS------------NLRVTF--GGGVPCSVLS--VSSTAIVCTTPPYANpGP 64

                           90
                   ....*....|....*....
gi 2462621636  110 YTVRVSVDGVPVTENNTCK 128
Cdd:cd00102     65 GPVEVTVDRGNGGITSSPL 83
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1157-1234 4.42e-07

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 50.78  E-value: 4.42e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1157 ISHIWPDSGSIAGGTLLTLSG--FGFNEN---SKVLVGNETCNVIEG---DLNRITCRTPKK----TEGTVDISVTTNGF 1224
Cdd:cd01180      3 ITEFFPLSGPLEGGTRLTICGsnLGLRKNdvrHGVRVGGVPCNPEPPeysSSEKIVCTTGPAgnpvFNGPVEVTVGHGSF 82

                           90
                   ....*....|
gi 2462621636 1225 QATARDAFSY 1234
Cdd:cd01180     83 RTESSEGFSF 92
IPT smart00429
ig-like, plexins, transcription factors;
2037-2123 6.14e-07

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 50.11  E-value: 6.14e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  2037 PLITAVSPKRGSTAGGTRLTVVGSGF-SENMEDVHITIAEAKCDVEYSNKTHIICMTDA-HTLSGWAPV-CVHIRGVGmA 2113
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLkSISVVFVEVGVGEAPCTFSPSSSTAIVCKTPPyHNIPGSVPVrTVGLRNGG-V 80

                            90
                    ....*....|
gi 2462621636  2114 KLDNADFLYV 2123
Cdd:smart00429   81 PSSPQPFTYV 90
PA14 smart00758
domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, ...
 341-467 9.09e-07

domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins;


Pssm-ID: 214807 [Multi-domain]  Cd Length: 136  Bit Score: 50.86  E-value: 9.09e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636   341 GLKLEVWNNSRPIRLEEIleynEKTPGYMGASWvDSASYIWLMEQDTFVARFSGFLVAPDSDVYRFYIKGDDRYAIYFSq 420
Cdd:smart00758    2 GLTGYYFENEKFSGLPEI----IDTDPLNTFYW-DSDKFGEGEKADNFSVRWTGYLKPPEDGEYTFSITSDDGARLWID- 75

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*..
gi 2462621636   421 tglpeDKVRIAYHSANANsyfssPTQRSDDIHLQKGKEYYIEILLQE 467
Cdd:smart00758   76 -----GKLVIDNWGKHEA-----RPSTSSTLYLLAGGTYPIRIEYFE 112
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1157-1234 9.66e-07

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 49.53  E-value: 9.66e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1157 ISHIWPDSGSIAGGTLLTLSGFGFNENS--KVLVGNETCNVIEGDLNRITCRTPKKTE-GTVDISVTTNGFQATARDAFS 1233
Cdd:cd01179      3 ITSLSPSYGPQSGGTRLTITGKHLNAGSsvRVTVGGQPCKILSVSSSQIVCLTPPSASpGEAPVKVLIDGARRLAPLVFT 82


                   .
gi 2462621636 1234 Y 1234
Cdd:cd01179     83 Y 83
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 271-329 1.54e-06

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 49.24  E-value: 1.54e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462621636  271 EVTMIFPSQGSIRGGTTLTISGRFF--DQTDFPVRVLVGGEPCDILN---VTENSICCKTPPKP 329
Cdd:cd01180      2 VITEFFPLSGPLEGGTRLTICGSNLglRKNDVRHGVRVGGVPCNPEPpeySSSEKIVCTTGPAG 65
IPT smart00429
ig-like, plexins, transcription factors;
1067-1153 2.46e-06

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 48.57  E-value: 2.46e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  1067 PLVLAISPSQGSYEEGTILTIVGSGFSPSSAVTVSVGPVG--CSLLSVDEKELKCQILNGSAGHAPVAVSMADVGLAqNV 1144
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEapCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLRNG-GV 80


                    ....*....
gi 2462621636  1145 GGEEFYFVY 1153
Cdd:smart00429   81 PSSPQPFTY 89
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1331-1390 2.77e-06

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 48.47  E-value: 2.77e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462621636 1331 EVTSMFPQRGSLFGGTEITIRG--FGFSTIPAENTVLLGSIPCNVT---SSSENVIKCILHSTGN 1390
Cdd:cd01180      2 VITEFFPLSGPLEGGTRLTICGsnLGLRKNDVRHGVRVGGVPCNPEppeYSSSEKIVCTTGPAGN 66
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1330-1384 3.06e-06

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 48.23  E-value: 3.06e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462621636 1330 LEVTSMFPQRGSLFGGTEITIRGFGFSTIPAEnTVLL-GSIPCNVTSSSENVIKCI 1384
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNL-RVTFgGGVPCSVLSVSSTAIVCT 55
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 146-255 3.67e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 47.83  E-value: 3.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  146 PTIRSITPLSGTP--GTLITIQGRIFtdvygsnialssnGKNVRILRVYIGGMPCELlIPQSDNlyglkldhpngdmgSM 223
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNF-------------GTDSSDLKVTIGGTPCTV-ISVSST--------------TI 52

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462621636  224 VCKTTGTFIGHHNVSFILDNDYGRSFPQKMAY 255
Cdd:pfam01833   53 VCTTPPGTSGLVNVSVTVGGGGISSSPLTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1956-2031 5.06e-06

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 47.44  E-value: 5.06e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462621636 1956 SFGGGQTMTVTGTGFN--PQNSIILVCGSECAIdrLRSDYTTLLCEIPSNNGTGaeqaCEVSV-VNGKDLSQSMTPFTY 2031
Cdd:pfam01833   12 PASGGTTITITGSNFGtdSSDLKVTIGGTPCTV--ISVSSTTIVCTTPPGTSGL----VNVSVtVGGGGISSSPLTFTY 84
PA14 pfam07691
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 363-467 5.22e-06

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


Pssm-ID: 400161 [Multi-domain]  Cd Length: 141  Bit Score: 48.90  E-value: 5.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  363 EKTPGYMGASWvDSASYIWLMEQDTFVARFSGFLVAPDSDVYRFYIKGDDRYAIYFSqtglpeDKVRIAYhsaNANSYFS 442
Cdd:pfam07691   22 IDTDPDNTFYW-DTDVPGFGEAPGDFSARWTGYLLPPESGTYTFGVASDDGARLWID------GELVIDN---WGQHPPD 91

                           90       100
                   ....*....|....*....|....*
gi 2462621636  443 SPTQRSDDIHLQKGKEYYIEILLQE 467
Cdd:pfam07691   92 ASPEESNTLYLVAGKLYPIRIEYFH 116
IPT smart00429
ig-like, plexins, transcription factors;
1658-1744 5.37e-06

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 47.42  E-value: 5.37e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  1658 LPNIDLVLPNAGSTTGMTSVTIKGSGF-AVSSAGVKVLMGHFPCKVLSVNYTAIECETSPAAQQLVD-----VDLLIHGV 1731
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLkSISVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSvpvrtVGLRNGGV 80

                            90
                    ....*....|...
gi 2462621636  1732 PAQCQgncTFSYL 1744
Cdd:smart00429   81 PSSPQ---PFTYV 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1566-1624 1.42e-05

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 46.29  E-value: 1.42e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462621636 1566 PSISNITPSTGTVNE--LITIIGHGFSNLPWANKVTIGSYPCVVEESSEDSITCHIDPQNS 1624
Cdd:cd00603      1 PVITSISPSSGPLSGgtRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAT 61
IPT smart00429
ig-like, plexins, transcription factors;
1330-1383 1.59e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 46.26  E-value: 1.59e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 2462621636  1330 LEVTSMFPQRGSLFGGTEITIRGFGFSTIPAEN-TVLLGSIPCNVTSSSENVIKC 1383
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFvEVGVGEAPCTFSPSSSTAIVC 56
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 31-126 2.78e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 45.13  E-value: 2.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636   31 PKVTEIIPKYGSINGATRLTIRGEGFSQanqfnygvdnselgNSVQLISSFQSITCDVEKDAshSTQITCYTRAMPEDSY 110
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGT--------------DSSDLKVTIGGTPCTVISVS--STTIVCTTPPGTSGLV 64

                           90
                   ....*....|....*.
gi 2462621636  111 TVRVSVDGVPVTENNT 126
Cdd:pfam01833   65 NVSVTVGGGGISSSPL 80
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1067-1152 4.04e-05

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 44.91  E-value: 4.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1067 PLVLAISPSQGSYEEGTILTIVGSGFSPSSAVTVSVGPVGCSLLSVDEKELKCQILNGSAGH-APVAVSmadVGLAQNVG 1145
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGeAPVKVL---IDGARRLA 77


                   ....*..
gi 2462621636 1146 GEEFYFV 1152
Cdd:cd01179     78 PLVFTYT 84
Halocyanin cd04220
Halocyanin is an archaea blue (type I) copper redox protein; Halocyanins are blue (type I) ...
 1406-1479 5.00e-05

Halocyanin is an archaea blue (type I) copper redox protein; Halocyanins are blue (type I) copper redox proteins found in halophilic archaea such as Natronomonas pharaonis (Natronobacterium pharaonis). Halocyanin may serve as a mobile electron carrier at a peripheral membrane protein. The copper-binding domain is present only once in some halocyanins and is duplicated in others.


Pssm-ID: 259882 [Multi-domain]  Cd Length: 92  Bit Score: 44.69  E-value: 5.00e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462621636 1406 GYAWSPPVLNVSVGDTVAWHWQTHpflrGIGYRIFSVSSPgsviydGKGFTSGRQKSTSG-SFSYQFTSPGIHYY 1479
Cdd:cd04220     11 GFAFDPAAIRVSPGTTVTWEWTGE----GGGHNVVAYEDP------ITAFDSGSTDSSEGeTYEHTFEETGEYRY 75
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 3202-3458 5.03e-05

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 48.76  E-value: 5.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 3202 ILSRNIKIVGEDYPgwsedsfgarVLVGSFTENMMTFKG-NARISNVEFYHSGqegfRDSTDPRYAvtflnlgqIQEHGS 3280
Cdd:COG3420     49 VIDKPLTLIGEGGA----------VIDGGGKGTVITITAdNVTVRGLTITGSG----DSLTDDDAG--------IYVRGA 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 3281 SY--IRGCAFHHGFSpAIGVFGTDGLDIDDNIIH------FTVGEGIRIWG-NANRVRGNLIalsvwpgtYQNRKdlsst 3351
Cdd:COG3420    107 DNavIENNRIENNLF-GIYLEGSDNNVIRNNTISgnrdlrADRGNGIHLWNsPGNVIEGNTI--------SGGRD----- 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 3352 lwhaAIEINRGTNTVLQNNVVAGfGRAGYRIDGepcpGQFNPVEkwfDNEAHGGLYGIY-MNQDGLpgcsLIQGFTIWTC 3430
Cdd:COG3420    173 ----GIYLEFSDNNVIRNNTIRN-LRYGIHYMY----SNDNLVE---GNTFRDNGAGIAlMYSKGN----TVRGNTILGN 236

                          250       260
                   ....*....|....*....|....*...
gi 2462621636 3431 WDYGIYFQTTESVHIYNVTLVDNGMAIF 3458
Cdd:COG3420    237 SGYGILLKESSDSVIEGNTISGNGKGIF 264
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1659-1745 5.81e-05

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 44.14  E-value: 5.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1659 PNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAgVKVLMGHFPCKVLSVNYTAIECETSPAAQ-QLVDVDLLIHGvpAQCQG 1737
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSS-VRVTVGGQPCKILSVSSSQIVCLTPPSASpGEAPVKVLIDG--ARRLA 77


                   ....*...
gi 2462621636 1738 NCTFSYLE 1745
Cdd:cd01179     78 PLVFTYTE 85
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1067-1152 9.19e-05

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 44.23  E-value: 9.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1067 PLVLAISPSQGSYEEGTILTIVGS--GFSPS-SAVTVSVGPVGCSLL---SVDEKELKCQI--LNGSAGHAPVAVSMADv 1138
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSnlGLRKNdVRHGVRVGGVPCNPEppeYSSSEKIVCTTgpAGNPVFNGPVEVTVGH- 79

                           90
                   ....*....|....
gi 2462621636 1139 GLAQNVGGEEFYFV 1152
Cdd:cd01180     80 GSFRTESSEGFSFV 93
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 146-244 9.82e-05

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 43.98  E-value: 9.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  146 PTIRSITPLSGTP--GTLITIqgriftdvYGSNiaLSSNGKNVRilrVYIGGMPCELLipqsdnlyglkldhpNGDMGSM 223
Cdd:cd00603      1 PVITSISPSSGPLsgGTRLTI--------TGSN--LGSGSPRVR---VTVGGVPCKVL---------------NVSSTEI 52

                           90       100
                   ....*....|....*....|..
gi 2462621636  224 VCKT-TGTFIGHHNVSFILDND 244
Cdd:cd00603     53 VCRTpAAATPGEGPVEVTVDGA 74
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1831-1897 1.02e-04

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 43.84  E-value: 1.02e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462621636 1831 PPVASLSPTSGSIGGGTTLVITGNGFY----PGNTTVTIGDEPCQII---SINPNEVYCRTPA----GTTGMVDVKIF 1897
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGlrknDVRHGVRVGGVPCNPEppeYSSSEKIVCTTGPagnpVFNGPVEVTVG 78
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1749-1827 1.63e-04

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 43.20  E-value: 1.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1749 PYITGVFPNS--VIGSVKVLIEGEGLGTVLEDIAVFIGNQQFRAIEVNENNITALVTPLPVGHHSVSVVVGSKGLALGNL 1826
Cdd:pfam01833    1 PVITSISPSSgpASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   .
gi 2462621636 1827 T 1827
Cdd:pfam01833   81 T 81
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1659-1745 1.72e-04

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 43.46  E-value: 1.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1659 PNIDLVLPNAGSTTGMTSVTIKGSGFAVSSAGV--KVLMGHFPCKVLSVNY---TAIECETSPAAQQLVD--VDLLIHGV 1731
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVrhGVRVGGVPCNPEPPEYsssEKIVCTTGPAGNPVFNgpVEVTVGHG 80

                           90
                   ....*....|....
gi 2462621636 1732 PAQCQGNCTFSYLE 1745
Cdd:cd01180     81 SFRTESSEGFSFVD 94
IPT smart00429
ig-like, plexins, transcription factors;
31-138 1.82e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 43.18  E-value: 1.82e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636    31 PKVTEIIPKYGSINGATRLTIRGEGFSQANQFNYGVDNSElgnsvqlissfqsITCDVekDASHSTQITCYTRAmpedsy 110
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGE-------------APCTF--SPSSSTAIVCKTPP------ 60

                            90       100
                    ....*....|....*....|....*...
gi 2462621636   111 tVRVSVDGVPVTENNTCKGHINSWECTF 138
Cdd:smart00429   61 -YHNIPGSVPVRTVGLRNGGVPSSPQPF 87
PetE COG3794
Plastocyanin [Energy production and conversion];
1407-1479 2.51e-04

Plastocyanin [Energy production and conversion];


Pssm-ID: 443008 [Multi-domain]  Cd Length: 76  Bit Score: 42.29  E-value: 2.51e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462621636 1407 YAWSPPVLNVSVGDTVAWHWQThpflrGIGYRIFSVSSPgsviydGKGFTSGRQKsTSGSFSYQFTSPGIHYY 1479
Cdd:COG3794      1 MAFEPATLTVKPGDTVTWVNTD-----SVPHNVTSDDGP------DGAFDSGLLA-PGETFSVTFDEPGTYDY 61
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1956-2031 3.20e-04

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 42.45  E-value: 3.20e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462621636 1956 SFGGGQTMTVTGTGFNP-QNSIILV-CGSECAIdrLRSDYTTLLCEIPSNNGTGAEQAcEVSVVNGKDLS-QSMTPFTY 2031
Cdd:cd00102     12 PVSGGTEVTITGSNFGSgSNLRVTFgGGVPCSV--LSVSSTAIVCTTPPYANPGPGPV-EVTVDRGNGGItSSPLTFTY 87
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 31-118 3.97e-04

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 42.30  E-value: 3.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636   31 PKVTEIIPKYGSINGATRLTIRGEGF-SQANQFNYGVdnsELGNSVqlissfqsitCDVEKD-ASHSTQITCYTRAMPED 108
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLgLRKNDVRHGV---RVGGVP----------CNPEPPeYSSSEKIVCTTGPAGNP 67

                           90
                   ....*....|..
gi 2462621636  109 SYT--VRVSVDG 118
Cdd:cd01180     68 VFNgpVEVTVGH 79
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1566-1651 8.34e-04

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 41.29  E-value: 8.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 1566 PSISNITPSTGTVN--ELITIIGHGFSNLPWAnKVTI-GSYPCVVEESSEDSITCHIDPQNSMDVGireTVTLTVYNLGT 1642
Cdd:cd00102      1 PVITSISPSSGPVSggTEVTITGSNFGSGSNL-RVTFgGGVPCSVLSVSSTAIVCTTPPYANPGPG---PVEVTVDRGNG 76


                   ....*....
gi 2462621636 1643 AINTLSNEF 1651
Cdd:cd00102     77 GITSSPLTF 85
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 146-207 9.46e-04

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 41.15  E-value: 9.46e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462621636  146 PTIRSITPLSGTP--GTLITIqgriftdvYGSNIALSSNGKNVRilrVYIGGMPCELLIPQSDN 207
Cdd:cd01180      1 PVITEFFPLSGPLegGTRLTI--------CGSNLGLRKNDVRHG---VRVGGVPCNPEPPEYSS 53
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1332-1384 1.02e-03

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 40.67  E-value: 1.02e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462621636 1332 VTSMFPQRGSLFGGTEITIRG----FGFSTipaenTVLLGSIPCNVTSSSENVIKCI 1384
Cdd:cd01179      3 ITSLSPSYGPQSGGTRLTITGkhlnAGSSV-----RVTVGGQPCKILSVSSSQIVCL 54
Amicyanin cd13921
Amicyanin is a type I blue copper protein that plays an essential role in electron transfer; ...
 1406-1479 1.40e-03

Amicyanin is a type I blue copper protein that plays an essential role in electron transfer; In Paracoccus denitrificans bacteria, amicyanin acts as an intermediary of a three-member redox complex along with methylamine dehydrogenase (MADH) and cytochrome c-551i. The electron is transferred from the active site of MADH via the amicyanin copper ion to the cytochrome heme iron. The electron transfer from MADH to cytochrome c-551i does not involve a ternary complex but occurs via a ping-pong mechanism in which amicyanin uses the same interface for the reactions with MADH and cytochrome c-551i.


Pssm-ID: 259988 [Multi-domain]  Cd Length: 81  Bit Score: 40.39  E-value: 1.40e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462621636 1406 GYAWSPPVLNVSVGDTVAWhwqthpflrgigyrIFSVSSPGSVIYDGKGFTSGRQKsTSGSFSYQFTSPGIHYY 1479
Cdd:cd13921      8 DFKFNPAEVTVKVGDTVTW--------------TNKDSVPHTVTAEDGAFDSGMLA-TGKSFSYTFTAAGTYDY 66
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1240-1310 3.02e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 39.61  E-value: 3.02e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462621636 1240 PIITDFSPKVRTILGEVNLTIKGYNFGNELTQ-NMAVYVGGKTCQILHWNFTD---IRCLLPKLSPGKHDIYVEV 1310
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDvRHGVRVGGVPCNPEPPEYSSsekIVCTTGPAGNPVFNGPVEV 75
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 272-327 5.42e-03

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 39.32  E-value: 5.42e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  272 VTMIFPSQGSIRGGTTLTISGRFFDQTDFP-VRVLVGG---EPCDILNVTEnsICCKTPP 327
Cdd:cd01181      3 ITRIEPEWSFLSGGTPITVTGTNLNTVQEPrIRVKYGGvekTSCKVRNSTL--MTCPAPS 60
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 3240-3333 7.61e-03

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 40.08  E-value: 7.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636 3240 GNARISNVEFYHSGQEGFRDSTDPRyaVTFLN-------LGQIQEHGSSY--IRGCAFHHGFSPAIGVFGTDGLDIDDNI 3310
Cdd:pfam13229   32 SNATIENNTITNNGGDGIEISGSSN--NTISNntisnngGGGIALRGSSNnlIENNTISNNGGAGIYLSDSSNNTIENNI 109

                           90       100
                   ....*....|....*....|....*
gi 2462621636 3311 IHFTVGEGIRI--WGNANRVRGNLI 3333
Cdd:pfam13229  110 IHNNGGSGIVIedSSNNVTISNNTV 134
IPT smart00429
ig-like, plexins, transcription factors;
1921-2031 8.09e-03

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 38.56  E-value: 8.09e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462621636  1921 IIPSRGPP--GTEIEITGSNFGFeileisvmINNIQWSFGGGqtmtvtgtgfnpqnsiilvcGSECAIDRLRSdyTTLLC 1998
Cdd:smart00429    7 ISPTSGPVsgGTEITLCGKNLKS--------ISVVFVEVGVG--------------------EAPCTFSPSSS--TAIVC 56

                            90       100       110
                    ....*....|....*....|....*....|....
gi 2462621636  1999 EIPS-NNGTGAEQACEVSVVNGkDLSQSMTPFTY 2031
Cdd:smart00429   57 KTPPyHNIPGSVPVRTVGLRNG-GVPSSPQPFTY 89
IPT smart00429
ig-like, plexins, transcription factors;
1240-1297 8.83e-03

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 38.17  E-value: 8.83e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462621636  1240 PIITDFSPKVRTILGEVNLTIKGYNFGNELTQNMAVYVGGKTCQILHWNFTDIRCLLP 1297
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAPCTFSPSSSTAIVCKTP 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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