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Conserved domains on  [gi|2462619481|ref|XP_054216485|]
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nibrin isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nbs1_C pfam08599
DNA damage repair protein Nbs1; This C terminal region of the DNA damage repair protein Nbs1 ...
 390-451 8.22e-33

DNA damage repair protein Nbs1; This C terminal region of the DNA damage repair protein Nbs1 has been identified to be necessary for the binding of Mre11 and Tel1.


:

Pssm-ID: 462531  Cd Length: 62  Bit Score: 118.56  E-value: 8.22e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462619481 390 KNFKKFKKVTYPGAGKLPHIIGGSDLIAHHARKNTELEEWLRQEMEVQNQHAKEESLADDLF 451
Cdd:pfam08599   1 KNFKKFRKVAYPGAGGLPHIIGGSDLLVHNRGKNSELEEWLKQAMEEESQSAREESLADDLF 62
NIBRIN_BRCT_II super family cl24920
Second BRCT domain on Nijmegen syndrome breakage protein;
1-32 1.14e-05

Second BRCT domain on Nijmegen syndrome breakage protein;


The actual alignment was detected with superfamily member pfam16508:

Pssm-ID: 465151  Cd Length: 118  Bit Score: 44.59  E-value: 1.14e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2462619481   1 MDMLQRQ-GLRPIPEAEIGLAVIFMTTKNYCDP 32
Cdd:pfam16508  86 ENELALRlGQRVIEQSEFLDAILHCSASKLCNP 118
 
Name Accession Description Interval E-value
Nbs1_C pfam08599
DNA damage repair protein Nbs1; This C terminal region of the DNA damage repair protein Nbs1 ...
 390-451 8.22e-33

DNA damage repair protein Nbs1; This C terminal region of the DNA damage repair protein Nbs1 has been identified to be necessary for the binding of Mre11 and Tel1.


Pssm-ID: 462531  Cd Length: 62  Bit Score: 118.56  E-value: 8.22e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462619481 390 KNFKKFKKVTYPGAGKLPHIIGGSDLIAHHARKNTELEEWLRQEMEVQNQHAKEESLADDLF 451
Cdd:pfam08599   1 KNFKKFRKVAYPGAGGLPHIIGGSDLLVHNRGKNSELEEWLKQAMEEESQSAREESLADDLF 62
NIBRIN_BRCT_II pfam16508
Second BRCT domain on Nijmegen syndrome breakage protein;
1-32 1.14e-05

Second BRCT domain on Nijmegen syndrome breakage protein;


Pssm-ID: 465151  Cd Length: 118  Bit Score: 44.59  E-value: 1.14e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2462619481   1 MDMLQRQ-GLRPIPEAEIGLAVIFMTTKNYCDP 32
Cdd:pfam16508  86 ENELALRlGQRVIEQSEFLDAILHCSASKLCNP 118
 
Name Accession Description Interval E-value
Nbs1_C pfam08599
DNA damage repair protein Nbs1; This C terminal region of the DNA damage repair protein Nbs1 ...
 390-451 8.22e-33

DNA damage repair protein Nbs1; This C terminal region of the DNA damage repair protein Nbs1 has been identified to be necessary for the binding of Mre11 and Tel1.


Pssm-ID: 462531  Cd Length: 62  Bit Score: 118.56  E-value: 8.22e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462619481 390 KNFKKFKKVTYPGAGKLPHIIGGSDLIAHHARKNTELEEWLRQEMEVQNQHAKEESLADDLF 451
Cdd:pfam08599   1 KNFKKFRKVAYPGAGGLPHIIGGSDLLVHNRGKNSELEEWLKQAMEEESQSAREESLADDLF 62
NIBRIN_BRCT_II pfam16508
Second BRCT domain on Nijmegen syndrome breakage protein;
1-32 1.14e-05

Second BRCT domain on Nijmegen syndrome breakage protein;


Pssm-ID: 465151  Cd Length: 118  Bit Score: 44.59  E-value: 1.14e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2462619481   1 MDMLQRQ-GLRPIPEAEIGLAVIFMTTKNYCDP 32
Cdd:pfam16508  86 ENELALRlGQRVIEQSEFLDAILHCSASKLCNP 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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