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Conserved domains on  [gi|2462618186|ref|XP_054215922|]
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early growth response protein 3 isoform X3 [Homo sapiens]

Protein Classification

DUF3446 and COG5048 domain-containing protein( domain architecture ID 12112530)

protein containing domains DUF3446, SFP1, and COG5048

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 106-192 7.46e-10

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


:

Pssm-ID: 463400  Cd Length: 104  Bit Score: 56.00  E-value: 7.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618186 106 GKFAFDSP----SNWCQDNIISLMSaGILGV-PPASGALSTQTSTAS-----------MVQPPQGDVEAMYPALPPY--S 167
Cdd:pfam11928   1 GKFSIDPQypggGSLWPEGLISLVS-GLVGMaNPPSSSSSSSPSSSSspnssgplctmSCSVQSSEMEHIYSAPPPYpsS 79

                          90       100
                  ....*....|....*....|....*
gi 2462618186 168 NCGDLYSEPVSFHDPQGNPGLAYSP 192
Cdd:pfam11928  80 GCGDLYQDPSAFLSTPSGPPLAYPP 104
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
322-395 2.16e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 2.16e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462618186 322 KPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSD--ERKRHAKIHLKQKEKKAEKGGAPSASSAPP 395
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 218-372 5.00e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.18  E-value: 5.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618186 218 HPNDMGSIPEH-KPFQGMDPIRvnpPPITPLETIKAFKDkqihPGFGSLPQPPLTLKPIRPRKYPNRPSKTpLHERPHAC 296
Cdd:COG5189   281 EESSLGFDYEFiHKSVGNKEIR---GGISTGEMIDVRKL----PCTNSSSNGKLAHGGERNIDTPSRMLKV-KDGKPYKC 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618186 297 PAEGCDRRFSRSDELTRHlRIHtGHK-----PFQCRICMRSFSRSDhltthirthtgeKPFACEFCGRKFARSDERKRHA 371
Cdd:COG5189   353 PVEGCNKKYKNQNGLKYH-MLH-GHQnqklhENPSPEKMNIFSAKD------------KPYRCEVCDKRYKNLNGLKYHR 418


                  .
gi 2462618186 372 K 372
Cdd:COG5189   419 K 419
 
Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 106-192 7.46e-10

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


Pssm-ID: 463400  Cd Length: 104  Bit Score: 56.00  E-value: 7.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618186 106 GKFAFDSP----SNWCQDNIISLMSaGILGV-PPASGALSTQTSTAS-----------MVQPPQGDVEAMYPALPPY--S 167
Cdd:pfam11928   1 GKFSIDPQypggGSLWPEGLISLVS-GLVGMaNPPSSSSSSSPSSSSspnssgplctmSCSVQSSEMEHIYSAPPPYpsS 79

                          90       100
                  ....*....|....*....|....*
gi 2462618186 168 NCGDLYSEPVSFHDPQGNPGLAYSP 192
Cdd:pfam11928  80 GCGDLYQDPSAFLSTPSGPPLAYPP 104
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
322-395 2.16e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 2.16e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462618186 322 KPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSD--ERKRHAKIHLKQKEKKAEKGGAPSASSAPP 395
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
zf-H2C2_2 pfam13465
Zinc-finger double domain;
338-363 1.73e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 1.73e-06
                          10        20
                  ....*....|....*....|....*.
gi 2462618186 338 HLTTHIRTHTGEKPFACEFCGRKFAR 363
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 218-372 5.00e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.18  E-value: 5.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618186 218 HPNDMGSIPEH-KPFQGMDPIRvnpPPITPLETIKAFKDkqihPGFGSLPQPPLTLKPIRPRKYPNRPSKTpLHERPHAC 296
Cdd:COG5189   281 EESSLGFDYEFiHKSVGNKEIR---GGISTGEMIDVRKL----PCTNSSSNGKLAHGGERNIDTPSRMLKV-KDGKPYKC 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618186 297 PAEGCDRRFSRSDELTRHlRIHtGHK-----PFQCRICMRSFSRSDhltthirthtgeKPFACEFCGRKFARSDERKRHA 371
Cdd:COG5189   353 PVEGCNKKYKNQNGLKYH-MLH-GHQnqklhENPSPEKMNIFSAKD------------KPYRCEVCDKRYKNLNGLKYHR 418


                  .
gi 2462618186 372 K 372
Cdd:COG5189   419 K 419
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 294-318 1.61e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|....*
gi 2462618186 294 HACPaeGCDRRFSRSDELTRHLRIH 318
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 323-370 4.21e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 4.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2462618186 323 PFQCRICMRSFSRSDHLTTHIRTHTGEKpfACEFCGRKFARSDERKRH 370
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
ZnF_C2H2 smart00355
zinc finger;
324-346 7.05e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 33.98  E-value: 7.05e-03
                           10        20
                   ....*....|....*....|...
gi 2462618186  324 FQCRICMRSFSRSDHLTTHIRTH 346
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 106-192 7.46e-10

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


Pssm-ID: 463400  Cd Length: 104  Bit Score: 56.00  E-value: 7.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618186 106 GKFAFDSP----SNWCQDNIISLMSaGILGV-PPASGALSTQTSTAS-----------MVQPPQGDVEAMYPALPPY--S 167
Cdd:pfam11928   1 GKFSIDPQypggGSLWPEGLISLVS-GLVGMaNPPSSSSSSSPSSSSspnssgplctmSCSVQSSEMEHIYSAPPPYpsS 79

                          90       100
                  ....*....|....*....|....*
gi 2462618186 168 NCGDLYSEPVSFHDPQGNPGLAYSP 192
Cdd:pfam11928  80 GCGDLYQDPSAFLSTPSGPPLAYPP 104
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
322-395 2.16e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 2.16e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462618186 322 KPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSD--ERKRHAKIHLKQKEKKAEKGGAPSASSAPP 395
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
zf-H2C2_2 pfam13465
Zinc-finger double domain;
338-363 1.73e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 1.73e-06
                          10        20
                  ....*....|....*....|....*.
gi 2462618186 338 HLTTHIRTHTGEKPFACEFCGRKFAR 363
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 218-372 5.00e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.18  E-value: 5.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618186 218 HPNDMGSIPEH-KPFQGMDPIRvnpPPITPLETIKAFKDkqihPGFGSLPQPPLTLKPIRPRKYPNRPSKTpLHERPHAC 296
Cdd:COG5189   281 EESSLGFDYEFiHKSVGNKEIR---GGISTGEMIDVRKL----PCTNSSSNGKLAHGGERNIDTPSRMLKV-KDGKPYKC 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618186 297 PAEGCDRRFSRSDELTRHlRIHtGHK-----PFQCRICMRSFSRSDhltthirthtgeKPFACEFCGRKFARSDERKRHA 371
Cdd:COG5189   353 PVEGCNKKYKNQNGLKYH-MLH-GHQnqklhENPSPEKMNIFSAKD------------KPYRCEVCDKRYKNLNGLKYHR 418


                  .
gi 2462618186 372 K 372
Cdd:COG5189   419 K 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
310-335 8.60e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 8.60e-06
                          10        20
                  ....*....|....*....|....*.
gi 2462618186 310 ELTRHLRIHTGHKPFQCRICMRSFSR 335
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
155-397 1.68e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 1.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618186 155 DVEAMYPALPPYSNCGDLYSEPVSFHDPQgnpglAYSPQDYQSAKPALDSNLFPMIPDYN---LYHHPNDM--GSIPEHK 229
Cdd:COG5048   170 PLPANSLSKDPSSNLSLLISSNVSTSIPS-----SSENSPLSSSYSIPSSSSDQNLENSSsslPLTTNSQLspKSLLSQS 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618186 230 PFQGMDPIRVNPPPITPletikaFKDKQIHPGFGSLPQPPLTLKPIRPRKypnrpsktplherPHACPAegCDRRFSRSD 309
Cdd:COG5048   245 PSSLSSSDSSSSASESP------RSSLPTASSQSSSPNESDSSSEKGFSL-------------PIKSKQ--CNISFSRSS 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618186 310 ELTRHLR--IHTG--HKPFQCRI--CMRSFSRSDHLTTHIRTHTGEKPFAC--EFCGRKFARSDERKRHAKIHLKQKEKK 381
Cdd:COG5048   304 PLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKN 383

                         250
                  ....*....|....*..
gi 2462618186 382 -AEKGGAPSASSAPPVS 397
Cdd:COG5048   384 dKKSETLSNSCIRNFKR 400
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
288-352 9.42e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 9.42e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462618186 288 PLHERPHACPaeGCDRRFSRSDELTRHLRIHTGHKPFQCRICMR--SFSRSDHLTTHIRTHTGEKPF 352
Cdd:COG5048    28 SNAPRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSD 92
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 324-346 2.56e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 2.56e-04
                          10        20
                  ....*....|....*....|...
gi 2462618186 324 FQCRICMRSFSRSDHLTTHIRTH 346
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
296-375 1.54e-03

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 40.77  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462618186 296 CPAEGCDRRFSRSDELTRHLRIHtgHKPFQCRICMR---------SFSRSDHLTTHIRTHTGEKPFA----CEFCGRKFA 362
Cdd:COG5236   154 CPKSKCHRRCGSLKELKKHYKAQ--HGFVLCSECIGnkkdfwneiRLFRSSTLRDHKNGGLEEEGFKghplCIFCKIYFY 231

                          90
                  ....*....|....*...
gi 2462618186 363 RSDE-----RKRHAKIHL 375
Cdd:COG5236   232 DDDElrrhcRLRHEACHI 249
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 324-346 1.61e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 35.70  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|...
gi 2462618186 324 FQCRICMRSFSRSDHLTTHIRTH 346
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 294-318 1.61e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|....*
gi 2462618186 294 HACPaeGCDRRFSRSDELTRHLRIH 318
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 323-370 4.21e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 4.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2462618186 323 PFQCRICMRSFSRSDHLTTHIRTHTGEKpfACEFCGRKFARSDERKRH 370
Cdd:PHA00733   73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
ZnF_C2H2 smart00355
zinc finger;
324-346 7.05e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 33.98  E-value: 7.05e-03
                           10        20
                   ....*....|....*....|...
gi 2462618186  324 FQCRICMRSFSRSDHLTTHIRTH 346
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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