|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
99-448 |
3.25e-70 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 227.34 E-value: 3.25e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 99 GMRTKYRTKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRY-PDcrcLNFGSWFTFSFPAALIILLLSWI 177
Cdd:COG0471 64 SIAAALGSEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATgIP---ISFFEWMLVGLPVALVGLLLLWL 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 178 WLQWLFlgfnfkemfkcgKTKTVQQKACAEVIKQEYQKLGPIRYQEIVTLVLFIIMALLWFSRDPGFVP-GWSALFSeyp 256
Cdd:COG0471 141 VLYRLL------------PPEIKEVPGSKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLHGIPiAVVALLG--- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 257 gfatdstvalligllfflipaktltkttptgeIVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGN 336
Cdd:COG0471 206 --------------------------------AVLLLLTGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLAD 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 337 KLSP-LGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIV 415
Cdd:COG0471 254 ALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIV 333
|
330 340 350
....*....|....*....|....*....|...
gi 2462615798 416 FSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTW 448
Cdd:COG0471 334 YGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
118-453 |
1.64e-38 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 145.59 E-value: 1.64e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 118 LCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDCrcLNFGSWFTFSFPAALIILLLSWIWLQWLFLGFNFKemfkcgkt 197
Cdd:pfam00939 178 WTVYQSTSITSAMFLTAMAPNLLLLGLMNSILGVT--ITWASWFLAAIPPGVILLLLAPLLLYVLYPPEIKS-------- 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 198 ktvqQKACAEVIKQEYQKLGPIRYQEIVTLVLFIIMALLWFsrdpgfvpgwsalFSEYPGFaTDSTVALLIGLLFFLipa 277
Cdd:pfam00939 248 ----VPDAKAIAKTELKELGPMTFREKALLGLFVLLLLLWI-------------FGGSLNI-DATTVAIIGLALMLL--- 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 278 ktltkttptgeivafdySPLITWKE-FQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPL--GSLPAWLIILISS 354
Cdd:pfam00939 307 -----------------LRILDWKDiVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSlsGFSPAMAFIIILS 369
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 355 LMVTSLTEVASNPATITLFLPILSPLAEAIH-VNPLYILIPSTLCTSFA-FLLPVANPPNAIVFSYGHLKVIDMVKAGLG 432
Cdd:pfam00939 370 LFYLSHYLFASATAHTAAMLPIFAAVAQAIPgAPPLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAI 449
|
330 340
....*....|....*....|.
gi 2462615798 433 VNIVGVAVVMLGICTWIVPMF 453
Cdd:pfam00939 450 LTIIGLLILLLLGNWWWKPLG 470
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
118-445 |
1.28e-36 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 138.49 E-value: 1.28e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 118 LCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDCrcLNFGSWFTFSFPAALIILLLSWIWLQWLFLgfnfkemfkcgkt 197
Cdd:cd01115 130 MPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQG--FSFFEFTPIGLPLLIIGLLYLWFIFRLAVL------------- 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 198 ktvqqkacaevikqeyqklgpiryqeIVTLVLFIIMALLwfsrdPGFVPgwsalfseypgfatdstvalligllfflipa 277
Cdd:cd01115 195 --------------------------IITIVLLAALAAI-----TGLLP------------------------------- 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 278 ktLTKTTPTGEIVAFDYSPLITWKEFQSFmPWDIAILVGGGFALADGCEESGLSKWIGNKLSP-LGSLPAWLIILISSLM 356
Cdd:cd01115 213 --VSVAIAIGAIVLVFGGVLLTKEDYKSI-DWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLPPFAILLLLCLL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 357 VTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIV 436
Cdd:cd01115 290 TLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSIL 369
|
....*....
gi 2462615798 437 GVAVVMLGI 445
Cdd:cd01115 370 SLVVSVTMI 378
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
74-448 |
4.57e-34 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 132.85 E-value: 4.57e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 74 NKTLTFGLVIPQVKPFQDVPLSKNSGMRTKYRtkkghvtrKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYfnTRYPDCR 153
Cdd:TIGR00785 121 NTARAGGILLPIIKSLLPLLGSKPEKSPRKIG--------KYLMLGIAYSASIGSSGFLTGSAPNALAAGI--LSKILGI 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 154 CLNFGSWFTFSFPAALIILLLSWIWLQWLFlgfnfkemfkcgKTKTVQQKACAEVIKQEYQKLGPIRYQEIVTLVLFIIM 233
Cdd:TIGR00785 191 QISWGDWFLAGLPLGIILLLLVPLLLYVLF------------PPELKLKDEVDLWAKEELEEMGPMSFREKALLGIFLLA 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 234 ALLWFSRDPGFVPgwsalfseypgfatDSTVALLIgllfflipaktltkttptgeIVAFDYSPLITWKEFQS-FMPWDIA 312
Cdd:TIGR00785 259 LLLWIFGGSLGIN--------------ASVVALLA--------------------VVLMLFLGIVTWKDIQKnKVAWNTL 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 313 ILVGGGFALADGCEESGLSKWIGNKLSP--LGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLY 390
Cdd:TIGR00785 305 ILFGGLIGLAGGLKKSGFIKWFSEKLVGilDGLSPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLEL 384
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2462615798 391 ILIPSTLCTSFA-FLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTW 448
Cdd:TIGR00785 385 LALALALSASLMgFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVGTLW 443
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
99-448 |
3.25e-70 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 227.34 E-value: 3.25e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 99 GMRTKYRTKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRY-PDcrcLNFGSWFTFSFPAALIILLLSWI 177
Cdd:COG0471 64 SIAAALGSEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATgIP---ISFFEWMLVGLPVALVGLLLLWL 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 178 WLQWLFlgfnfkemfkcgKTKTVQQKACAEVIKQEYQKLGPIRYQEIVTLVLFIIMALLWFSRDPGFVP-GWSALFSeyp 256
Cdd:COG0471 141 VLYRLL------------PPEIKEVPGSKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLHGIPiAVVALLG--- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 257 gfatdstvalligllfflipaktltkttptgeIVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGN 336
Cdd:COG0471 206 --------------------------------AVLLLLTGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLAD 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 337 KLSP-LGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIV 415
Cdd:COG0471 254 ALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIV 333
|
330 340 350
....*....|....*....|....*....|...
gi 2462615798 416 FSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTW 448
Cdd:COG0471 334 YGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
118-453 |
1.64e-38 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 145.59 E-value: 1.64e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 118 LCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDCrcLNFGSWFTFSFPAALIILLLSWIWLQWLFLGFNFKemfkcgkt 197
Cdd:pfam00939 178 WTVYQSTSITSAMFLTAMAPNLLLLGLMNSILGVT--ITWASWFLAAIPPGVILLLLAPLLLYVLYPPEIKS-------- 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 198 ktvqQKACAEVIKQEYQKLGPIRYQEIVTLVLFIIMALLWFsrdpgfvpgwsalFSEYPGFaTDSTVALLIGLLFFLipa 277
Cdd:pfam00939 248 ----VPDAKAIAKTELKELGPMTFREKALLGLFVLLLLLWI-------------FGGSLNI-DATTVAIIGLALMLL--- 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 278 ktltkttptgeivafdySPLITWKE-FQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPL--GSLPAWLIILISS 354
Cdd:pfam00939 307 -----------------LRILDWKDiVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSlsGFSPAMAFIIILS 369
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 355 LMVTSLTEVASNPATITLFLPILSPLAEAIH-VNPLYILIPSTLCTSFA-FLLPVANPPNAIVFSYGHLKVIDMVKAGLG 432
Cdd:pfam00939 370 LFYLSHYLFASATAHTAAMLPIFAAVAQAIPgAPPLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAI 449
|
330 340
....*....|....*....|.
gi 2462615798 433 VNIVGVAVVMLGICTWIVPMF 453
Cdd:pfam00939 450 LTIIGLLILLLLGNWWWKPLG 470
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
118-445 |
1.28e-36 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 138.49 E-value: 1.28e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 118 LCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDCrcLNFGSWFTFSFPAALIILLLSWIWLQWLFLgfnfkemfkcgkt 197
Cdd:cd01115 130 MPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQG--FSFFEFTPIGLPLLIIGLLYLWFIFRLAVL------------- 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 198 ktvqqkacaevikqeyqklgpiryqeIVTLVLFIIMALLwfsrdPGFVPgwsalfseypgfatdstvalligllfflipa 277
Cdd:cd01115 195 --------------------------IITIVLLAALAAI-----TGLLP------------------------------- 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 278 ktLTKTTPTGEIVAFDYSPLITWKEFQSFmPWDIAILVGGGFALADGCEESGLSKWIGNKLSP-LGSLPAWLIILISSLM 356
Cdd:cd01115 213 --VSVAIAIGAIVLVFGGVLLTKEDYKSI-DWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLPPFAILLLLCLL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 357 VTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIV 436
Cdd:cd01115 290 TLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSIL 369
|
....*....
gi 2462615798 437 GVAVVMLGI 445
Cdd:cd01115 370 SLVVSVTMI 378
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
74-448 |
4.57e-34 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 132.85 E-value: 4.57e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 74 NKTLTFGLVIPQVKPFQDVPLSKNSGMRTKYRtkkghvtrKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYfnTRYPDCR 153
Cdd:TIGR00785 121 NTARAGGILLPIIKSLLPLLGSKPEKSPRKIG--------KYLMLGIAYSASIGSSGFLTGSAPNALAAGI--LSKILGI 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 154 CLNFGSWFTFSFPAALIILLLSWIWLQWLFlgfnfkemfkcgKTKTVQQKACAEVIKQEYQKLGPIRYQEIVTLVLFIIM 233
Cdd:TIGR00785 191 QISWGDWFLAGLPLGIILLLLVPLLLYVLF------------PPELKLKDEVDLWAKEELEEMGPMSFREKALLGIFLLA 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 234 ALLWFSRDPGFVPgwsalfseypgfatDSTVALLIgllfflipaktltkttptgeIVAFDYSPLITWKEFQS-FMPWDIA 312
Cdd:TIGR00785 259 LLLWIFGGSLGIN--------------ASVVALLA--------------------VVLMLFLGIVTWKDIQKnKVAWNTL 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 313 ILVGGGFALADGCEESGLSKWIGNKLSP--LGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLY 390
Cdd:TIGR00785 305 ILFGGLIGLAGGLKKSGFIKWFSEKLVGilDGLSPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLEL 384
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2462615798 391 ILIPSTLCTSFA-FLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTW 448
Cdd:TIGR00785 385 LALALALSASLMgFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVGTLW 443
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
117-445 |
4.10e-24 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 103.87 E-value: 4.10e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 117 CLCIAYSSTIGGLTTITGTSTNLIFAEYFNtrypdcrcLNFGSWFTFSFPAALIILLLSWIWLQWLFLGFNFKEmfkcgk 196
Cdd:cd00625 122 LLALAFAANIGGAATPIGNPPNLIIASLSG--------LGFLDFLAFMAPPALGLLLLLLGLLYLLFRKKLLLP------ 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 197 tktvqQKACAEVIKQEYQKLGPIRYQEIVTLVLFIIMALLWFsrdpgfvpgwsalFSEYPGFATDSTVAlligllfflip 276
Cdd:cd00625 188 -----DEDKLTVLAEPLPARPLLKKFLLLALLLLLLFVLLFF-------------FLIPLGLIALLGAL----------- 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 277 aktltkttptgeIVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLM 356
Cdd:cd00625 239 ------------LLLLLLVRGLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLL 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 357 VTSLTEVASNPATITLFLPILSPLAEA-----IHVNPLYILIPSTLCTSFAFLLPVANPPNAIVfsygHLKVIDMVKAGL 431
Cdd:cd00625 307 SALLSNFISNVPTVALLLPIAASLAPPepawlALALGSTLGGNLTLIGSLANLIPLGAAENAGV----GISFGEFLKVGL 382
|
330
....*....|....
gi 2462615798 432 GVNIVGVAVVMLGI 445
Cdd:cd00625 383 PLTLLSLVVSLLYL 396
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
289-471 |
6.57e-15 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 75.81 E-value: 6.57e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 289 IVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPA 368
Cdd:pfam03600 19 AVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 369 TITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLL-PVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICT 447
Cdd:pfam03600 99 TVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTAtPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALLLVGLLPLL 178
|
170 180
....*....|....*....|....
gi 2462615798 448 WIVPMFDLYTYPSWAPAMSNETMP 471
Cdd:pfam03600 179 LIFRKLLPVRKEEEAELEELRKRA 202
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
106-393 |
3.82e-14 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 73.50 E-value: 3.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 106 TKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNtrypdcrcLNFGSWFTFSFPAALIILLLSWIWLQWLFLG 185
Cdd:pfam03600 111 ARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASALG--------LSFGDFGFFMFPPVGVALLLVGLLPLLLIFR 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 186 FNFKEMFKcgktktvqqkacaevIKQEYQKLGPIRYQEIVTLVLFIIMALLWFSrdpGFVPGWSALFSeypgfatdstva 265
Cdd:pfam03600 183 KLLPVRKE---------------EEAELEELRKRAIKDKLLLAISALVLALVIL---GFLLLSVLALA------------ 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 266 lligllfflipaktltkttptgEIVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGslP 345
Cdd:pfam03600 233 ----------------------GALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS--G 288
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2462615798 346 AWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILI 393
Cdd:pfam03600 289 LLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPLA 336
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
297-460 |
3.90e-11 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 64.58 E-value: 3.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 297 LITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILIsSLMVTSLTEVASNPATITLFLPI 376
Cdd:cd00625 27 VVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRLLLLL-MLLTAALSAFFSNDATAVLLTPI 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 377 LSPLAEAIH-VNPLYILIPSTLCTSFA-FLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMlgICTWIVPMFD 454
Cdd:cd00625 106 VLALLRKLGlSPPVPLLLALAFAANIGgAATPIGNPPNLIIASLSGLGFLDFLAFMAPPALGLLLLLL--GLLYLLFRKK 183
|
....*.
gi 2462615798 455 LYTYPS 460
Cdd:cd00625 184 LLLPDE 189
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
310-418 |
1.02e-08 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 56.82 E-value: 1.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 310 DIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPL 389
Cdd:cd01115 47 PAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPS 126
|
90 100 110
....*....|....*....|....*....|
gi 2462615798 390 YILIPSTLCTSFAFLL-PVANPPNAIVFSY 418
Cdd:cd01115 127 RLLMPLAFAASIGGMLtLIGTPPNLVASGY 156
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
297-443 |
3.01e-08 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 55.52 E-value: 3.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 297 LITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPATITLFLPI 376
Cdd:COG1055 41 VVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPV 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462615798 377 LSPLAEAIHVNPLYILIPSTLCTSFA-FLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVML 443
Cdd:COG1055 121 VLAIARRLGLNPVPFLIAIVFAANIGgAATPIGNPTNIMIASAGGLSFLDFLANLFPPSLVSLLVTLL 188
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
317-451 |
8.06e-08 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 54.00 E-value: 8.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 317 GGFALADGCEESGLSKWIGNK-LSPLGSLPAWLIILIsSLMVTSLTEVASNPATITLFLPILSPLAEAIHVN-----PLY 390
Cdd:COG0471 2 GGFVLAAALEKTGLGRRIALLlLKRFGGSPLRLLLGL-MLATALLSAFISNTARAAMMLPIALSIAAALGSEkrskfGSA 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 391 ILIP---STLCTSFAFLlpVANPPNAIVFSY------GHLKVIDMVKAGLGVNIVGVAVVMLgICTWIVP 451
Cdd:COG0471 81 LLLPiafAASIGGMGTL--IGTPPNLIAAGLleeatgIPISFFEWMLVGLPVALVGLLLLWL-VLYRLLP 147
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
117-393 |
1.99e-05 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 46.66 E-value: 1.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 117 CLCIAYSSTIGGLTTITGTSTNLIFAEYFNtrypdcrcLNFGSWFTFSFPAALIILLLSWIWLQWLFLGfnfkemfkcgk 196
Cdd:COG1055 136 LIAIVFAANIGGAATPIGNPTNIMIASAGG--------LSFLDFLANLFPPSLVSLLVTLLVLYLLFRK----------- 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 197 tktvQQKACAEVIKQEYQKLGPIRYQEIVTLVLFIIMALLWFSRDPGFVPGWSALFseypgfatdstvalligllfflip 276
Cdd:COG1055 197 ----ELPAAPDLEDDPKEAIKDRRLLRISLLVLALLLVGFVLHSFLGLPPALIALL------------------------ 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 277 aktltkttptGEIVAFDYSPLITWKEFQSfMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLM 356
Cdd:COG1055 249 ----------GAAVLLLLARVDVREVLKK-VDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWL 317
|
250 260 270
....*....|....*....|....*....|....*..
gi 2462615798 357 VTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILI 393
Cdd:COG1055 318 SAILSAVVDNVPLVAALLPLIPDLGATGNPEPLWLAL 354
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
294-449 |
1.41e-04 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 44.16 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 294 YSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPATITLF 373
Cdd:cd01116 32 ATLSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLM 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462615798 374 LPILSPLAEAIHVNPLYILIPSTLCTSF-AFLLPVANPPNAIVFSYGHLKVIDMVkAGLGVNIVGVAVVMLGICTWI 449
Cdd:cd01116 112 VPVTIRLCEVLGLNPVPVLISEVIAANIgGAATLIGDPPNIMIGSAAGLTFNDFL-LHMLPSVVLALVVTFILLYFL 187
|
|
| ArsB_permease |
cd01118 |
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ... |
309-421 |
6.09e-04 |
|
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.
Pssm-ID: 238538 [Multi-domain] Cd Length: 416 Bit Score: 41.87 E-value: 6.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 309 WDIAILVGGGFALADGCEESGLSKWIGNKLSPL----GSLPAWLIILISSLMvtslTEVASNPATITLFLPILSPLAEAI 384
Cdd:cd01118 52 WDVTLTLIGVILLSLLLDEEGFFEWVAALAARWargsGRKLFTLIVLLGAAV----TAFFANDGTALILTPIVIALLRAL 127
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 2462615798 385 HVNPL----YILIPSTLCTSFAFLLPVANPPNAIVFSYGHL 421
Cdd:cd01118 128 GAKKNrtlpFLYACAFIADAASLPLPISNLVNIVTAGYFGI 168
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
118-184 |
1.96e-03 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 40.50 E-value: 1.96e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462615798 118 LCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYpdcRCLNFGSWFTFSFPAALIILLLSWIWLQWLFL 184
Cdd:COG1055 352 LALALGATLGGNLTPIGSAANVIVLGIAEKKG---IKISFGEFLKVGLPLTLLTLLIALLYLLLLYF 415
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
311-418 |
9.95e-03 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 38.09 E-value: 9.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462615798 311 IAILVGGGFALADGCEESGLSKWIGNKLSPLG---SLPAWLIILISSLMVTSLTevASNPATIT-LFLPILSPLAEAIHV 386
Cdd:TIGR00785 65 TIWLFFGAFILATALVKTGLGKRIAYKLVGKMggtTLGLGYFLVFLETLLAPMW--PSNTARAGgILLPIIKSLLPLLGS 142
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 2462615798 387 NP-----------LYILIPSTLCTSFAFLlpVANPPNAIVFSY 418
Cdd:TIGR00785 143 KPeksprkigkylMLGIAYSASIGSSGFL--TGSAPNALAAGI 183
|
|
| |
