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Conserved domains on  [gi|2462614441|ref|XP_054214219|]
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leucine-rich repeat and calponin homology domain-containing protein 4 isoform X13 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
65-241 4.57e-42

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 153.17  E-value: 4.57e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  65 YDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIV 143
Cdd:COG4886   110 SNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDL 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 144 SNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPeELGDLP-LVRLDFSCNRVSRIPVS 222
Cdd:COG4886   190 SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTnLEELDLSNNQLTDLPPL 268

                         170
                  ....*....|....*....
gi 2462614441 223 fCRLRHLQVILLDSNPLQS 241
Cdd:COG4886   269 -ANLTNLKTLDLSNNQLTD 286
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
65-241 4.57e-42

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 153.17  E-value: 4.57e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  65 YDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIV 143
Cdd:COG4886   110 SNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDL 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 144 SNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPeELGDLP-LVRLDFSCNRVSRIPVS 222
Cdd:COG4886   190 SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTnLEELDLSNNQLTDLPPL 268

                         170
                  ....*....|....*....
gi 2462614441 223 fCRLRHLQVILLDSNPLQS 241
Cdd:COG4886   269 -ANLTNLKTLDLSNNQLTD 286
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
46-220 1.60e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 78.59  E-value: 1.60e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  46 TLNLSNRRLKHFPRG--------AARSYDLSD--------ITQADLSRNRFPEVPEaacQLVS-LEGLSLYHNCLRCLNP 108
Cdd:PRK15370  203 TLILDNNELKSLPENlqgniktlYANSNQLTSipatlpdtIQEMELSINRITELPE---RLPSaLQSLDLFHNKISCLPE 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 109 ALGNltALTYLNLSRNQLSLLPPYicqLPLRV--LIVSNNKLGALPPDIGTlgSLRQLDVSSNELQSLPSELCglSSLRD 186
Cdd:PRK15370  280 NLPE--ELRYLSVYDNSIRTLPAH---LPSGIthLNVQSNSLTALPETLPP--GLKTLEAGENALTSLPASLP--PELQV 350

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2462614441 187 LNVRRNQLSTLPEELGDlPLVRLDFSCNRVSRIP 220
Cdd:PRK15370  351 LDVSKNQITVLPETLPP-TITTLDVSRNALTNLP 383
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-198 2.36e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.96  E-value: 2.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  90 LVSLEGLSLYHNCLRCLNpALGNLTALTYLNLSRNQLsllPP--YICQLP---------LRVLIVSNNKLGALPPdIGTL 158
Cdd:cd21340    67 LVNLKKLYLGGNRISVVE-GLENLTNLEELHIENQRL---PPgeKLTFDPrslaalsnsLRVLNISGNNIDSLEP-LAPL 141

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462614441 159 GSLRQLDVSSNELQSLpSELC----GLSSLRDLNVRRNQLSTLP 198
Cdd:cd21340   142 RNLEQLDASNNQISDL-EELLdllsSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
74-126 2.98e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 2.98e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462614441  74 DLSRNRFPEV-PEAACQLVSLEGLSLYHNCLRCLNP-ALGNLTALTYLNLSRNQL 126
Cdd:pfam13855   7 DLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPgAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
65-241 4.57e-42

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 153.17  E-value: 4.57e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  65 YDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIV 143
Cdd:COG4886   110 SNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTnLKELDL 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 144 SNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPeELGDLP-LVRLDFSCNRVSRIPVS 222
Cdd:COG4886   190 SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTnLEELDLSNNQLTDLPPL 268

                         170
                  ....*....|....*....
gi 2462614441 223 fCRLRHLQVILLDSNPLQS 241
Cdd:COG4886   269 -ANLTNLKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-243 6.12e-38

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.99  E-value: 6.12e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  44 TGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNclrclnPALGNLTALTYLNLSR 123
Cdd:COG4886    49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 124 NQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELG 202
Cdd:COG4886   123 NQLTDLPEELANLTnLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLG 202

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2462614441 203 DLP-LVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPP 243
Cdd:COG4886   203 NLTnLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP 244
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-239 3.90e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 120.42  E-value: 3.90e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  33 SAERALEEAVATGTLNLSNRRLKHFPRGAARsydLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGN 112
Cdd:COG4886   104 SGNEELSNLTNLESLDLSGNQLTDLPEELAN---LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGN 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 113 LTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLP---------------- 175
Cdd:COG4886   181 LTNLKELDLSNNQITDLPEPLGNLTnLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPelgnltnleeldlsnn 260

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 176 -----SELCGLSSLRDLNVRRNQLSTLP-EELGDLPLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPL 239
Cdd:COG4886   261 qltdlPPLANLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLL 330
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
64-244 1.84e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.69  E-value: 1.84e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  64 SYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLI 142
Cdd:COG4886    23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTnLTELD 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 143 VSNNKlgalppDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLP-LVRLDFSCNRVSRIPV 221
Cdd:COG4886   103 LSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTnLKSLDLSNNQLTDLPE 176

                         170       180
                  ....*....|....*....|...
gi 2462614441 222 SFCRLRHLQVILLDSNPLQSPPA 244
Cdd:COG4886   177 ELGNLTNLKELDLSNNQITDLPE 199
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
46-220 1.60e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 78.59  E-value: 1.60e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  46 TLNLSNRRLKHFPRG--------AARSYDLSD--------ITQADLSRNRFPEVPEaacQLVS-LEGLSLYHNCLRCLNP 108
Cdd:PRK15370  203 TLILDNNELKSLPENlqgniktlYANSNQLTSipatlpdtIQEMELSINRITELPE---RLPSaLQSLDLFHNKISCLPE 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 109 ALGNltALTYLNLSRNQLSLLPPYicqLPLRV--LIVSNNKLGALPPDIGTlgSLRQLDVSSNELQSLPSELCglSSLRD 186
Cdd:PRK15370  280 NLPE--ELRYLSVYDNSIRTLPAH---LPSGIthLNVQSNSLTALPETLPP--GLKTLEAGENALTSLPASLP--PELQV 350

                         170       180       190
                  ....*....|....*....|....*....|....
gi 2462614441 187 LNVRRNQLSTLPEELGDlPLVRLDFSCNRVSRIP 220
Cdd:PRK15370  351 LDVSKNQITVLPETLPP-TITTLDVSRNALTNLP 383
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 47-239 1.07e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.88  E-value: 1.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  47 LNLSNRRLK-HFPRGAarsydLSDITQADLSRNRFP-EVPEAACQLVSLEGLSLYHNCLRCLNPA-LGNLTALTYLNLSR 123
Cdd:PLN00113  123 LNLSNNNFTgSIPRGS-----IPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGKIPNsLTNLTSLEFLTLAS 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 124 NQLS-LLPPYICQLPLRVLIV--SNNKLGALPPDIGTLGSLRQLDVSSNELQ-SLPSELCGLSSLRDLNVRRNQLS-TLP 198
Cdd:PLN00113  198 NQLVgQIPRELGQMKSLKWIYlgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIP 277

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2462614441 199 EELGDLP-LVRLDFSCNRVS-RIPVSFCRLRHLQVILLDSNPL 239
Cdd:PLN00113  278 PSIFSLQkLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNF 320
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-198 2.36e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.96  E-value: 2.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  90 LVSLEGLSLYHNCLRCLNpALGNLTALTYLNLSRNQLsllPP--YICQLP---------LRVLIVSNNKLGALPPdIGTL 158
Cdd:cd21340    67 LVNLKKLYLGGNRISVVE-GLENLTNLEELHIENQRL---PPgeKLTFDPrslaalsnsLRVLNISGNNIDSLEP-LAPL 141

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462614441 159 GSLRQLDVSSNELQSLpSELC----GLSSLRDLNVRRNQLSTLP 198
Cdd:cd21340   142 RNLEQLDASNNQISDL-EELLdllsSWPSLRELDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 82-251 4.35e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 68.34  E-value: 4.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  82 EVPEAACQLVSLEGLSL-YHNCLRCLNPALGNLTALTYLNLSRNQLS-LLPPYICQLP-LRVLIVSNNKL-GALPPDIGT 157
Cdd:PLN00113  227 EIPYEIGGLTSLNHLDLvYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQkLISLDLSDNSLsGEIPELVIQ 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 158 LGSLRQLDVSSNELQ-SLPSELCGLSSLRDLNVRRNQLS-TLPEELGDL-PLVRLDFSCNRVS-RIPVSFCRLRHLQVIL 233
Cdd:PLN00113  307 LQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHnNLTVLDLSTNNLTgEIPEGLCSSGNLFKLI 386

                         170
                  ....*....|....*...
gi 2462614441 234 LDSNPLQSppaQRPGSVG 251
Cdd:PLN00113  387 LFSNSLEG---EIPKSLG 401
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 67-243 1.66e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 63.65  E-value: 1.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  67 LSDITQADLSRNRFPEVPE-AACQlvSLEGLSLYHNCLRCLnPALGNLTALTYLNLSRNQLSLLPPyICQLP-LRVLIVS 144
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNlSLCK--NLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIEN-LENLVnLKKLYLG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 145 NNK------LGALPpdigtlgSLRQLDVSSnelQSLPSE---------LCGLS-SLRDLNVRRNQLSTLpEELGDLP-LV 207
Cdd:cd21340    77 GNRisvvegLENLT-------NLEELHIEN---QRLPPGekltfdprsLAALSnSLRVLNISGNNIDSL-EPLAPLRnLE 145

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2462614441 208 RLDFSCNRVSRIP---VSFCRLRHLQVILLDSNPLQSPP 243
Cdd:cd21340   146 QLDASNNQISDLEellDLLSSWPSLRELDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 112-229 1.36e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.25  E-value: 1.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 112 NLTALTYLNLSRNQLS-LLPPYICQLPLRVLIVSNNKL-GALPPDIGTLGSLRQLDVSSNELQS-LPSELCGLSSLRDLN 188
Cdd:PLN00113  450 DMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFsGAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLD 529

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462614441 189 VRRNQLS-TLPEELGDLP-LVRLDFSCNRVS-RIPVSFCRLRHL 229
Cdd:PLN00113  530 LSHNQLSgQIPASFSEMPvLSQLDLSQNQLSgEIPKNLGNVESL 573
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 76-239 4.09e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.71  E-value: 4.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  76 SRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPA-LGNLTALTYLNLSRNQLS-LLPPYICQLP--LRVLIVSNNKLGAL 151
Cdd:PLN00113  317 SNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKnLGKHNNLTVLDLSTNNLTgEIPEGLCSSGnlFKLILFSNSLEGEI 396

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 152 PPDIGTLGSLRQ------------------------LDVSSNELQ-SLPSELCGLSSLRDLNVRRNQLS-TLPEELGDLP 205
Cdd:PLN00113  397 PKSLGACRSLRRvrlqdnsfsgelpseftklplvyfLDISNNNLQgRINSRKWDMPSLQMLSLARNKFFgGLPDSFGSKR 476

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2462614441 206 LVRLDFSCNRVS-RIPVSFCRLRHLQVILLDSNPL 239
Cdd:PLN00113  477 LENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKL 511
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 68-242 1.45e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.17  E-value: 1.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  68 SDITQADLS-RNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPA--LGNLTALTYLNLSRNQLSLLPPYICQLPLRVLIVS 144
Cdd:PLN00113   69 SRVVSIDLSgKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDdiFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLS 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 145 NNKL-GALPPDIGTLGSLRQLDVSSNELQS-LPSELCGLSSLRDLNVRRNQLS-TLPEELGDL----------------- 204
Cdd:PLN00113  149 NNMLsGEIPNDIGSFSSLKVLDLGGNVLVGkIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMkslkwiylgynnlsgei 228

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2462614441 205 --------PLVRLDFSCNRVS-RIPVSFCRLRHLQVILLDSNPLQSP 242
Cdd:PLN00113  229 pyeiggltSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSGP 275
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-188 1.99e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.10  E-value: 1.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  46 TLNLSNRRLKHFPRGAARsydLSDITQADLSRNRFPEVPEAAcQLVSLEGLSLYHNCLRCLnPALGNLTALTYLNLSRNQ 125
Cdd:COG4886   209 ELDLSGNQLTDLPEPLAN---LTNLETLDLSNNQLTDLPELG-NLTNLEELDLSNNQLTDL-PPLANLTNLKTLDLSNNQ 283

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462614441 126 LS-----LLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLN 188
Cdd:COG4886   284 LTdlklkELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
67-245 4.57e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 55.17  E-value: 4.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  67 LSDITQADLSRNRFPEVPEAACQLVSleglslYHNCLRCLnPALGnlTALTYLNLSRNQLSLLPpyicQLP--LRVLIVS 144
Cdd:PRK15387  304 LQELSVSDNQLASLPALPSELCKLWA------YNNQLTSL-PTLP--SGLQELSVSDNQLASLP----TLPseLYKLWAY 370

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 145 NNKLGALPpdiGTLGSLRQLDVSSNELQSLPselCGLSSLRDLNVRRNQLSTLPEelgdLP--LVRLDFSCNRVSRIPVS 222
Cdd:PRK15387  371 NNRLTSLP---ALPSGLKELIVSGNRLTSLP---VLPSELKELMVSGNRLTSLPM----LPsgLLSLSVYRNQLTRLPES 440

                         170       180
                  ....*....|....*....|...
gi 2462614441 223 FCRLRHLQVILLDSNPLQSPPAQ 245
Cdd:PRK15387  441 LIHLSSETTVNLEGNPLSERTLQ 463
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
83-247 6.29e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.70  E-value: 6.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  83 VPEAACQLVsleglsLYHNCLRCLNPAL-GNLTALTylnLSRNQLSLLPPyicQLP--LRVLIVSNNKLGALPPDIGTlg 159
Cdd:PRK15370  197 IPEQITTLI------LDNNELKSLPENLqGNIKTLY---ANSNQLTSIPA---TLPdtIQEMELSINRITELPERLPS-- 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 160 SLRQLDVSSNELQSLPSELCglSSLRDLNVRRNQLSTLPEELGDlPLVRLDFSCNRVSRIPVSFCrlRHLQVILLDSNPL 239
Cdd:PRK15370  263 ALQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHLPS-GITHLNVQSNSLTALPETLP--PGLKTLEAGENAL 337


                  ....*...
gi 2462614441 240 QSPPAQRP 247
Cdd:PRK15370  338 TSLPASLP 345
PLN03150 PLN03150
hypothetical protein; Provisional
 129-211 8.12e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 54.44  E-value: 8.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 129 LPPYICQLP-LRVLIVSNNKL-GALPPDIGTLGSLRQLDVSSNELQ-SLPSELCGLSSLRDLNVRRNQLS-TLPEELGDL 204
Cdd:PLN03150  434 IPNDISKLRhLQSINLSGNSIrGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALGGR 513


                  ....*..
gi 2462614441 205 PLVRLDF 211
Cdd:PLN03150  514 LLHRASF 520
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 47-176 1.52e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.62  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  47 LNLSNRRlkhFPRGAARSYDLSDITQADLSRNRFPE-VPEAACQLVSLEGLSLYHNCLRCLNPA-LGNLTALTYLNLSRN 124
Cdd:PLN00113  457 LSLARNK---FFGGLPDSFGSKRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSGEIPDeLSSCKKLVSLDLSHN 533

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462614441 125 QLS-LLPPYICQLP-LRVLIVSNNKL-GALPPDIGTLGSLRQLDVSSNELQ-SLPS 176
Cdd:PLN00113  534 QLSgQIPASFSEMPvLSQLDLSQNQLsGEIPKNLGNVESLVQVNISHNHLHgSLPS 589
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
117-250 2.10e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.08  E-value: 2.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 117 TYLNLSRNQLSLLPPYIcqlplrvlivsnnklgalPPDIGTLgslrQLDvsSNELQSLPSELCGlsSLRDLNVRRNQLST 196
Cdd:PRK15370  181 TELRLKILGLTTIPACI------------------PEQITTL----ILD--NNELKSLPENLQG--NIKTLYANSNQLTS 234

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462614441 197 LPEELGD--------------LP------LVRLDFSCNRVSRIPVSFCR-LRHLQVIlldSNPLQSPPAQRPGSV 250
Cdd:PRK15370  235 IPATLPDtiqemelsinriteLPerlpsaLQSLDLFHNKISCLPENLPEeLRYLSVY---DNSIRTLPAHLPSGI 306
LRR_8 pfam13855
Leucine rich repeat;
74-126 2.98e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 2.98e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462614441  74 DLSRNRFPEV-PEAACQLVSLEGLSLYHNCLRCLNP-ALGNLTALTYLNLSRNQL 126
Cdd:pfam13855   7 DLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPgAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
182-239 1.61e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 1.61e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462614441 182 SSLRDLNVRRNQLSTLPEE-LGDLP-LVRLDFSCNRVSRI-PVSFCRLRHLQVILLDSNPL 239
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSnLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 92-214 3.82e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.55  E-value: 3.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  92 SLEGLSLYHNCLRC-----LNPALGNLTALTYLNLSRNQLS------LLPPYICQLPLRVLIVSNNKLG-----ALPPDI 155
Cdd:COG5238   265 TVETLYLSGNQIGAegaiaLAKALQGNTTLTSLDLSVNRIGdegaiaLAEGLQGNKTLHTLNLAYNGIGaqgaiALAKAL 344

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462614441 156 GTLGSLRQLDVSSNEL-----QSLPSELCGLSSLRDLNVRRNQLSTL-PEELGDL----PLVRLDFSCN 214
Cdd:COG5238   345 QENTTLHSLDLSDNQIgdegaIALAKYLEGNTTLRELNLGKNNIGKQgAEALIDAlqtnRLHTLILDGN 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-244 5.19e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 5.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  87 ACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDV 166
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462614441 167 SSNELQSLPSELCGLSSLRDLNVRRNqlstlpEELGDLP-LVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPA 244
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTnLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE 153
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
70-243 2.68e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 43.23  E-value: 2.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  70 ITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYlnlSRNQLSLLPPYICQLplrvLIVSNN--K 147
Cdd:PRK15387  224 ITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELSIFSN---PLTHLPALPSGLCKL----WIFGNQltS 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 148 LGALPPdigtlgSLRQLDVSSNELQS---LPSELCGL--------------SSLRDLNVRRNQLSTLP------------ 198
Cdd:PRK15387  297 LPVLPP------GLQELSVSDNQLASlpaLPSELCKLwaynnqltslptlpSGLQELSVSDNQLASLPtlpselyklway 370

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462614441 199 -EELGDLP-----LVRLDFSCNRVSRIPVSFCRLRHLQVillDSNPLQSPP 243
Cdd:PRK15387  371 nNRLTSLPalpsgLKELIVSGNRLTSLPVLPSELKELMV---SGNRLTSLP 418
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 103-245 7.06e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 7.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 103 LRCLNPALGNLTALTYLNLSRNQLSLLPPYICQL-----PLRVLIVSNNKLG--ALPPDIGTLGS----LRQLDVSSNEL 171
Cdd:cd00116    70 LQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESllrssSLQELKLNNNGLGdrGLRLLAKGLKDlppaLEKLVLGRNRL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441 172 -----QSLPSELCGLSSLRDLNVRRNQLS-----TLPEELGDLP-LVRLDFSCNRVSRIPVS-----FCRLRHLQVILLD 235
Cdd:cd00116   150 egascEALAKALRANRDLKELNLANNGIGdagirALAEGLKANCnLEVLDLNNNGLTDEGASalaetLASLKSLEVLNLG 229

                         170
                  ....*....|
gi 2462614441 236 SNPLQSPPAQ 245
Cdd:cd00116   230 DNNLTDAGAA 239
LRR_8 pfam13855
Leucine rich repeat;
116-171 7.45e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 7.45e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462614441 116 LTYLNLSRNQLSLLPPYICQ-LP-LRVLIVSNNKLGALPPD-IGTLGSLRQLDVSSNEL 171
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKgLSnLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
92-148 9.72e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 9.72e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  92 SLEGLSLYHNCLRCLNP-ALGNLTALTYLNLSRNQLSLLPPY-ICQLP-LRVLIVSNNKL 148
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPsLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 92-126 1.70e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 1.70e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2462614441  92 SLEGLSLYHNCLRCLnPALGNLTALTYLNLSRNQL 126
Cdd:pfam12799   2 NLEVLDLSNNQITDI-PPLAKLPNLETLDLSGNNK 35
PLN03150 PLN03150
hypothetical protein; Provisional
 83-185 6.37e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 38.64  E-value: 6.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614441  83 VPEAACQLVSLEGLSLYHNCLR-CLNPALGNLTALTYLNLSRNQLS-LLPPYICQL-PLRVLIVSNNKL-GALPPDIGTL 158
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLtSLRILNLNGNSLsGRVPAALGGR 513

                          90       100
                  ....*....|....*....|....*...
gi 2462614441 159 GSLR-QLDVSSNelqslpSELCGLSSLR 185
Cdd:PLN03150  514 LLHRaSFNFTDN------AGLCGIPGLR 535
PLN03150 PLN03150
hypothetical protein; Provisional
 149-222 9.57e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 38.26  E-value: 9.57e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462614441 149 GALPPDIGTLGSLRQLDVSSNELQ-SLPSELCGLSSLRDLNVRRNQLS-TLPEELGDLPLVR-LDFSCNRVS-RIPVS 222
Cdd:PLN03150  432 GFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRiLNLNGNSLSgRVPAA 509
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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