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Conserved domains on  [gi|2462614412|ref|XP_054214205|]
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importin subunit alpha-8 isoform X7 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
1-392 1.10e-141

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 414.67  E-value: 1.10e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412   1 MLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQA 80
Cdd:COG5064    98 LLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQA 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412  81 VWALGNIAGDGPEFRDNVITSNAIPHLLALI-SPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQHQDS 159
Cdd:COG5064   178 VWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDP 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412 160 EVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQ 239
Cdd:COG5064   258 EVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLS 337

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412 240 HNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATM--DQLIQLVHSGVLE 317
Cdd:COG5064   338 SPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLNrpDIIRYLVSQGFIK 417

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412 318 PLVNLLTAPDVKIVLIILDVISCILQAAE----KRSEKENL-CLLIEELGGIDRIEALQLHENRQIGQSALNIIEKHFGE 392
Cdd:COG5064   418 PLCDLLDVVDNKIIEVALDAIENILKVGEqdrlRYGKNINIyAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGE 497
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
1-392 1.10e-141

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 414.67  E-value: 1.10e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412   1 MLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQA 80
Cdd:COG5064    98 LLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQA 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412  81 VWALGNIAGDGPEFRDNVITSNAIPHLLALI-SPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQHQDS 159
Cdd:COG5064   178 VWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDP 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412 160 EVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQ 239
Cdd:COG5064   258 EVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLS 337

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412 240 HNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATM--DQLIQLVHSGVLE 317
Cdd:COG5064   338 SPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLNrpDIIRYLVSQGFIK 417

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412 318 PLVNLLTAPDVKIVLIILDVISCILQAAE----KRSEKENL-CLLIEELGGIDRIEALQLHENRQIGQSALNIIEKHFGE 392
Cdd:COG5064   418 PLCDLLDVVDNKIIEVALDAIENILKVGEqdrlRYGKNINIyAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGE 497
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 356-395 7.93e-15

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 68.39  E-value: 7.93e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462614412 356 LLIEELGGIDRIEALQLHENRQIGQSALNIIEKHFGEVSD 395
Cdd:pfam16186   1 LLIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEE 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 218-258 8.84e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.19  E-value: 8.84e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462614412  218 TDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAA 258
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 35-297 2.61e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 43.55  E-value: 2.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412   35 QFEAAWALTNIASGTSEQTR-AVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALIsp 113
Cdd:PLN03200   462 QQEYAVALLAILTDEVDESKwAITAAGGIPPLVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVESAGAVPALLWLL-- 539

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412  114 tlpitflrnitwtlsnlcRNKNPYPCDTAVKqilpALLHLLQHQDSEVLSDacwALSYLTDGSNKRIGQVVNtgVLPRlv 193
Cdd:PLN03200   540 ------------------KNGGPKGQEIAAK----TLTKLVRTADAATISQ---LTALLLGDLPESKVHVLD--VLGH-- 590

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412  194 VLMTSSELNVLTP------SLRTVGNIVTGTDEQTQ--------------------MAIDAgMLNVLPQLLQHNKPSIQK 247
Cdd:PLN03200   591 VLSVASLEDLVREgsaandALRTLIQLLSSSKEETQekaasvladifssrqdlcesLATDE-IINPCIKLLTNNTEAVAT 669

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462614412  248 EAAWALSNVaAGPCHHIQQL--LAYDVLPPLVALLKNGEFKVQKEAVWMVAN 297
Cdd:PLN03200   670 QSARALAAL-SRSIKENRKVsyAAEDAIKPLIKLAKSSSIEVAEQAVCALAN 720
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
1-392 1.10e-141

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 414.67  E-value: 1.10e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412   1 MLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQA 80
Cdd:COG5064    98 LLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQA 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412  81 VWALGNIAGDGPEFRDNVITSNAIPHLLALI-SPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQHQDS 159
Cdd:COG5064   178 VWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDP 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412 160 EVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQ 239
Cdd:COG5064   258 EVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLS 337

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412 240 HNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATM--DQLIQLVHSGVLE 317
Cdd:COG5064   338 SPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLNrpDIIRYLVSQGFIK 417

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412 318 PLVNLLTAPDVKIVLIILDVISCILQAAE----KRSEKENL-CLLIEELGGIDRIEALQLHENRQIGQSALNIIEKHFGE 392
Cdd:COG5064   418 PLCDLLDVVDNKIIEVALDAIENILKVGEqdrlRYGKNINIyAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGE 497
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 356-395 7.93e-15

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 68.39  E-value: 7.93e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462614412 356 LLIEELGGIDRIEALQLHENRQIGQSALNIIEKHFGEVSD 395
Cdd:pfam16186   1 LLIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEE 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 218-258 3.33e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 52.07  E-value: 3.33e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2462614412 218 TDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAA 258
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 49-88 5.66e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 51.30  E-value: 5.66e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2462614412  49 TSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIA 88
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
215-331 1.05e-08

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 57.21  E-value: 1.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412 215 VTGTDEQTQMAIDAGMLNVLPQLLQ-----------------------HNKPSIQK------------------------ 247
Cdd:COG5064    54 VSEEAESSFIPMEQQFYSELPQLTQqlfsddieqqlqavykfrkllskETSPPIQPvidagvvprfvefmdeiqrdmlqf 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412 248 EAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATM--DQLIQlvhSGVLEPLVNLL-- 323
Cdd:COG5064   134 EAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGcrDYVLQ---CGALEPLLGLLls 210


                  ....*...
gi 2462614412 324 TAPDVKIV 331
Cdd:COG5064   211 SAIHISML 218
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 218-258 8.84e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.19  E-value: 8.84e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462614412  218 TDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAA 258
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 49-88 1.22e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.81  E-value: 1.22e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462614412   49 TSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIA 88
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 34-87 1.02e-06

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 45.44  E-value: 1.02e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462614412  34 LQFEAAWALTNIASGTSEQTRAVVEGgAIQPLIELLSSSNVAVCEQAVWALGNI 87
Cdd:pfam13513   3 VREAAALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 146-174 3.08e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 43.60  E-value: 3.08e-06
                          10        20
                  ....*....|....*....|....*....
gi 2462614412 146 ILPALLHLLQHQDSEVLSDACWALSYLTD 174
Cdd:pfam00514  13 AVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT COG1413
HEAT repeat [General function prediction only];
19-169 3.40e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.16  E-value: 3.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412  19 IPRMVEFLKSSlYPCLQFEAAWALTNIASGTseqtravveggAIQPLIELLSSSNVAVCEQAVWALGNIAgdgpefrdnv 98
Cdd:COG1413    18 VPALIAALADE-DPDVRAAAARALGRLGDPR-----------AVPALLEALKDPDPEVRAAAAEALGRIG---------- 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462614412  99 iTSNAIPHLL-ALISPTLPITflRNITWTLSNLcrnknpypcdtAVKQILPALLHLLQHQDSEVLSDACWAL 169
Cdd:COG1413    76 -DPEAVPALIaALKDEDPEVR--RAAAEALGRL-----------GDPAAVPALLEALKDPDWEVRRAAARAL 133
HEAT COG1413
HEAT repeat [General function prediction only];
38-174 3.85e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.16  E-value: 3.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412  38 AAWALTNIasGTSEqtravveggAIQPLIELLSSSNVAVCEQAVWALGNIAGDGpefrdnvitsnAIPHLLALISPTLPI 117
Cdd:COG1413     5 AARALGRL--GDPA---------AVPALIAALADEDPDVRAAAARALGRLGDPR-----------AVPALLEALKDPDPE 62

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462614412 118 TfLRNITWTLSNLcrnknpypcdtAVKQILPALLHLLQHQDSEVLSDACWALSYLTD 174
Cdd:COG1413    63 V-RAAAAEALGRI-----------GDPEAVPALIAALKDEDPEVRRAAAEALGRLGD 107
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 135-174 2.32e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 41.26  E-value: 2.32e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462614412  135 NPYPCDTAVKQ-ILPALLHLLQHQDSEVLSDACWALSYLTD 174
Cdd:smart00185   1 DDENKQAVVDAgGLPALVELLKSEDEEVVKEAAWALSNLSS 41
HEAT COG1413
HEAT repeat [General function prediction only];
144-293 7.72e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.31  E-value: 7.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412 144 KQILPALLHLLQHQDSEVLSDACWALSYLTDgsnkrigqvvnTGVLPRLVVLMTSSELNVLTPSLRTVGNIvtGTDEqtq 223
Cdd:COG1413    15 PAAVPALIAALADEDPDVRAAAARALGRLGD-----------PRAVPALLEALKDPDPEVRAAAAEALGRI--GDPE--- 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412 224 mAIDAgmlnvLPQLLQHNKPSIQKEAAWALSNVAAGpchhiqqllayDVLPPLVALLKNGEFKVQKEAVW 293
Cdd:COG1413    79 -AVPA-----LIAALKDEDPEVRRAAAEALGRLGDP-----------AAVPALLEALKDPDWEVRRAAAR 131
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 35-297 2.61e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 43.55  E-value: 2.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412   35 QFEAAWALTNIASGTSEQTR-AVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALIsp 113
Cdd:PLN03200   462 QQEYAVALLAILTDEVDESKwAITAAGGIPPLVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVESAGAVPALLWLL-- 539

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412  114 tlpitflrnitwtlsnlcRNKNPYPCDTAVKqilpALLHLLQHQDSEVLSDacwALSYLTDGSNKRIGQVVNtgVLPRlv 193
Cdd:PLN03200   540 ------------------KNGGPKGQEIAAK----TLTKLVRTADAATISQ---LTALLLGDLPESKVHVLD--VLGH-- 590

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412  194 VLMTSSELNVLTP------SLRTVGNIVTGTDEQTQ--------------------MAIDAgMLNVLPQLLQHNKPSIQK 247
Cdd:PLN03200   591 VLSVASLEDLVREgsaandALRTLIQLLSSSKEETQekaasvladifssrqdlcesLATDE-IINPCIKLLTNNTEAVAT 669

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462614412  248 EAAWALSNVaAGPCHHIQQL--LAYDVLPPLVALLKNGEFKVQKEAVWMVAN 297
Cdd:PLN03200   670 QSARALAAL-SRSIKENRKVsyAAEDAIKPLIKLAKSSSIEVAEQAVCALAN 720
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 6-47 3.14e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.18  E-value: 3.14e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462614412    6 KNPPLKLVIEAGLIPRMVEFLKSSlYPCLQFEAAWALTNIAS 47
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSE-DEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 7-47 3.28e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 3.28e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2462614412   7 NPPLKLVIEAGLIPRMVEFLKSSlYPCLQFEAAWALTNIAS 47
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSP-DEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 262-300 5.20e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.43  E-value: 5.20e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2462614412 262 HHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFAT 300
Cdd:pfam00514   3 ENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 243-298 9.79e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.96  E-value: 9.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462614412 243 PSIQKEAAWALSNVAaGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANF 298
Cdd:pfam13513   1 WRVREAAALALGSLA-EGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 101-292 1.23e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 41.24  E-value: 1.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412  101 SNAIPHLLALI-SPTLPITFlrNITWTLSNLCRNKnpypcDTAVKQIL----PALLHLLQHQDSEVLSDACWALSYLTDG 175
Cdd:PLN03200    57 SQAMPLLVSLLrSGTLGAKV--NAAAVLGVLCKEE-----DLRVKVLLggciPPLLSLLKSGSAEAQKAAAEAIYAVSSG 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412  176 SNK-RIGQ--VVNTGVLPRLVVLMTS------SELNVLTPSLRtvgNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQ 246
Cdd:PLN03200   130 GLSdHVGSkiFSTEGVVPSLWDQLQPgnkqdkVVEGLLTGALR---NLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQ 206

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 2462614412  247 KEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNG-EFKVQKEAV 292
Cdd:PLN03200   207 ANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGQGnEVSVRAEAA 253
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 121-172 1.95e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.19  E-value: 1.95e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462614412 121 RNITWTLSNLCrNKNPYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYL 172
Cdd:pfam13513   5 EAAALALGSLA-EGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 92-132 2.11e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.51  E-value: 2.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2462614412  92 PEFRDNVITSNAIPHLLALISPTlPITFLRNITWTLSNLCR 132
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSP-DEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 176-216 2.64e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.51  E-value: 2.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2462614412 176 SNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVT 216
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 19-111 5.04e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.16  E-value: 5.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412  19 IPRMVEFLKSSLYPCLQFEAAWALTNIASGTseqtravveggAIQPLIELLSSSNVAVCEQAVWALGNIAgdgpefrdnv 98
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGDPE-----------AVPALLELLKDEDPAVRRAAAEALGKIG---------- 59

                          90
                  ....*....|...
gi 2462614412  99 iTSNAIPHLLALI 111
Cdd:pfam13646  60 -DPEALPALLELL 71
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 214-345 7.92e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 38.93  E-value: 7.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412  214 IVTGTDEQTQMAID-AGMLNVLPQLLQHNKPSIQKEAAWALSNVaagpCHHIQQLLA----YDVLPPLVALLKNGEFKVQ 288
Cdd:PLN03200   472 ILTDEVDESKWAITaAGGIPPLVQLLETGSQKAKEDSATVLWNL----CCHSEDIRAcvesAGAVPALLWLLKNGGPKGQ 547

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462614412  289 KEAVwmvanfatgATMDQLIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCILQAA 345
Cdd:PLN03200   548 EIAA---------KTLTKLVRTADAATISQLTALLLGDLPESKVHVLDVLGHVLSVA 595
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 37-91 8.78e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 38.54  E-value: 8.78e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462614412   37 EAAWALTNIASGTSE-QTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDG 91
Cdd:PLN03200   670 QSARALAALSRSIKEnRKVSYAAEDAIKPLIKLAKSSSIEVAEQAVCALANLLSDP 725
HEAT COG1413
HEAT repeat [General function prediction only];
19-88 9.13e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 36.53  E-value: 9.13e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412  19 IPRMVEFLKSSlYPCLQFEAAWALTNIASGTseqtravveggAIQPLIELLSSSNVAVCEQAVWALGNIA 88
Cdd:COG1413    80 VPALIAALKDE-DPEVRRAAAEALGRLGDPA-----------AVPALLEALKDPDWEVRRAAARALGRLG 137
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 11-114 9.40e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 38.54  E-value: 9.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462614412   11 KLVIEAGLIPRMVEFLKSSlYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSN-VAVCEQAVWALGNIAG 89
Cdd:PLN03200   183 SATLEAGGVDILVKLLSSG-NSDAQANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGQGNeVSVRAEAAGALEALSS 261

                           90       100
                   ....*....|....*....|....*.
gi 2462614412   90 DGPEFRDNVITSNAIPHLL-ALISPT 114
Cdd:PLN03200   262 QSKEAKQAIADAGGIPALInATVAPS 287
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 262-299 9.78e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 33.94  E-value: 9.78e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462614412  262 HHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFA 299
Cdd:smart00185   3 ENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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