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Conserved domains on  [gi|2462613589|ref|XP_054213821|]
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metalloreductase STEAP2 isoform X1 [Homo sapiens]

Protein Classification

COG2085 and Ferric_reduct domain-containing protein( domain architecture ID 11946522)

COG2085 and Ferric_reduct domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
33-222 3.41e-36

Predicted dinucleotide-binding enzyme [General function prediction only];


:

Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 132.99  E-value: 3.41e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613589  33 VGVIGSGDFAKSLTIRLIRCGYHVVIGSRNP----KFASEFFPHVVDVThHEDALTKTNIIFVAIHREHYTS-LWDLRHL 107
Cdd:COG2085     1 IGIIGTGNIGSALARRLAAAGHEVVIGSRDPekaaALAAELGPGARAGT-NAEAAAAADVVVLAVPYEAVPDvLESLGDA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613589 108 LVGKILIDVSNNMRINQYP-------ESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDAS--RQVYICSNNIQARQQV 178
Cdd:COG2085    80 LAGKIVIDATNPLPERDGFildppggGSAAELVAALLPGARVVKAFNTIGAAVLADPARPAGgrRDVFVAGDDAEAKAVV 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2462613589 179 IELARQLNFIPIDLGSLSSAREIENL-PLRLFTLWRGPVVVAISL 222
Cdd:COG2085   160 AALIEDLGFDPVDAGPLANARRLEPLtPLLINLARTAGLELGFRL 204
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 259-405 2.28e-08

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


:

Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 52.27  E-value: 2.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613589 259 LPIVAITLLSLVYLAGLLAAAYQLYYGTKYrrfppwlETWLQCRKQLGLLSFFFAMVHVAYSLCLPMRRSERYLFlnmay 338
Cdd:pfam01794   1 LGILALALLPLLLLLALRNNPLEWLTGLSY-------DRLLLFHRWLGRLAFLLALLHVILYLIYWLRFSLEGIL----- 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462613589 339 qqvhanienswneeEVWRIEMYISFGIMSLGLLSLLAVTSIPSVSNaLNWREFSFIQSTLGYVALLI 405
Cdd:pfam01794  69 --------------DLLLKRPYNILGIIALVLLVLLAITSLPPFRR-LSYELFLYLHILLAVAFLLL 120
 
Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
33-222 3.41e-36

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 132.99  E-value: 3.41e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613589  33 VGVIGSGDFAKSLTIRLIRCGYHVVIGSRNP----KFASEFFPHVVDVThHEDALTKTNIIFVAIHREHYTS-LWDLRHL 107
Cdd:COG2085     1 IGIIGTGNIGSALARRLAAAGHEVVIGSRDPekaaALAAELGPGARAGT-NAEAAAAADVVVLAVPYEAVPDvLESLGDA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613589 108 LVGKILIDVSNNMRINQYP-------ESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDAS--RQVYICSNNIQARQQV 178
Cdd:COG2085    80 LAGKIVIDATNPLPERDGFildppggGSAAELVAALLPGARVVKAFNTIGAAVLADPARPAGgrRDVFVAGDDAEAKAVV 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2462613589 179 IELARQLNFIPIDLGSLSSAREIENL-PLRLFTLWRGPVVVAISL 222
Cdd:COG2085   160 AALIEDLGFDPVDAGPLANARRLEPLtPLLINLARTAGLELGFRL 204
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
34-119 6.53e-20

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 84.21  E-value: 6.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613589  34 GVIGSGDFAKSLTIRLIRCGYH--VVIGSRNPKFASEFFPHV-VDVTH--HEDALTKTNIIFVAIHREHYTSLW-DLRHL 107
Cdd:pfam03807   1 GFIGAGNMGEALARGLVAAGPHevVVANSRNPEKAEELAEEYgVGATAvdNEEAAEEADVVFLAVKPEDAPDVLsELSDL 80

                          90
                  ....*....|..
gi 2462613589 108 LVGKILIDVSNN 119
Cdd:pfam03807  81 LKGKIVISIAAG 92
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 259-405 2.28e-08

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 52.27  E-value: 2.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613589 259 LPIVAITLLSLVYLAGLLAAAYQLYYGTKYrrfppwlETWLQCRKQLGLLSFFFAMVHVAYSLCLPMRRSERYLFlnmay 338
Cdd:pfam01794   1 LGILALALLPLLLLLALRNNPLEWLTGLSY-------DRLLLFHRWLGRLAFLLALLHVILYLIYWLRFSLEGIL----- 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462613589 339 qqvhanienswneeEVWRIEMYISFGIMSLGLLSLLAVTSIPSVSNaLNWREFSFIQSTLGYVALLI 405
Cdd:pfam01794  69 --------------DLLLKRPYNILGIIALVLLVLLAITSLPPFRR-LSYELFLYLHILLAVAFLLL 120
 
Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
33-222 3.41e-36

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 132.99  E-value: 3.41e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613589  33 VGVIGSGDFAKSLTIRLIRCGYHVVIGSRNP----KFASEFFPHVVDVThHEDALTKTNIIFVAIHREHYTS-LWDLRHL 107
Cdd:COG2085     1 IGIIGTGNIGSALARRLAAAGHEVVIGSRDPekaaALAAELGPGARAGT-NAEAAAAADVVVLAVPYEAVPDvLESLGDA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613589 108 LVGKILIDVSNNMRINQYP-------ESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDAS--RQVYICSNNIQARQQV 178
Cdd:COG2085    80 LAGKIVIDATNPLPERDGFildppggGSAAELVAALLPGARVVKAFNTIGAAVLADPARPAGgrRDVFVAGDDAEAKAVV 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2462613589 179 IELARQLNFIPIDLGSLSSAREIENL-PLRLFTLWRGPVVVAISL 222
Cdd:COG2085   160 AALIEDLGFDPVDAGPLANARRLEPLtPLLINLARTAGLELGFRL 204
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
34-119 6.53e-20

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 84.21  E-value: 6.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613589  34 GVIGSGDFAKSLTIRLIRCGYH--VVIGSRNPKFASEFFPHV-VDVTH--HEDALTKTNIIFVAIHREHYTSLW-DLRHL 107
Cdd:pfam03807   1 GFIGAGNMGEALARGLVAAGPHevVVANSRNPEKAEELAEEYgVGATAvdNEEAAEEADVVFLAVKPEDAPDVLsELSDL 80

                          90
                  ....*....|..
gi 2462613589 108 LVGKILIDVSNN 119
Cdd:pfam03807  81 LKGKIVISIAAG 92
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 259-405 2.28e-08

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 52.27  E-value: 2.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613589 259 LPIVAITLLSLVYLAGLLAAAYQLYYGTKYrrfppwlETWLQCRKQLGLLSFFFAMVHVAYSLCLPMRRSERYLFlnmay 338
Cdd:pfam01794   1 LGILALALLPLLLLLALRNNPLEWLTGLSY-------DRLLLFHRWLGRLAFLLALLHVILYLIYWLRFSLEGIL----- 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462613589 339 qqvhanienswneeEVWRIEMYISFGIMSLGLLSLLAVTSIPSVSNaLNWREFSFIQSTLGYVALLI 405
Cdd:pfam01794  69 --------------DLLLKRPYNILGIIALVLLVLLAITSLPPFRR-LSYELFLYLHILLAVAFLLL 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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