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Conserved domains on  [gi|2462613137|ref|XP_054213605|]
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laminin subunit beta-4 isoform X3 [Homo sapiens]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 13614046)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
28-263 1.54e-94

Laminin N-terminal (Domain VI);


:

Pssm-ID: 459653  Cd Length: 230  Bit Score: 304.89  E-value: 1.54e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137   28 CHPTTGDLLVGRntQLMASSTCGLSRAQKYCILSYLEGEQKCFICDSRFPYdpydqpNSHTIENVIvSFEPDREKKWWQS 107
Cdd:pfam00055    1 CYPAFGNLAFGR--EVSATSTCGLNGPERYCILSGLEGGKKCFICDSRDPH------NSHPPSNLT-DSNNGTNETWWQS 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137  108 ENGL---DHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAKDCATSFpNITSGQAQGVGD--IV 182
Cdd:pfam00055   72 ETGViqyENVNLTLDLGKEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTF-GRPSGPSRGIKDdeVI 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137  183 CDSKYSDIEPSTGGEVVLKVL--DPSFEIENpYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQndSLDKYYYALYEMI 260
Cdd:pfam00055  151 CTSEYSDISPLTGGEVIFSTLegRPSANIFD-YSPELQDWLTATNIRIRLLRLHTLGDELLDDPS--VLRKYYYAISDIS 227

                   ...
gi 2462613137  261 VRG 263
Cdd:pfam00055  228 VGG 230
Mplasa_alph_rch super family cl37461
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
1254-1714 8.24e-13

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


The actual alignment was detected with superfamily member TIGR04523:

Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 73.52  E-value: 8.24e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1254 QIMQLNEQLKAV-YEFQDLKDTIERAKNEADLLLEDLqeeidlqsSVLNASIADSSENIKKYYHISSSAEKKINETSSTI 1332
Cdd:TIGR04523   69 KINNSNNKIKILeQQIKDLNDKLKKNKDKINKLNSDL--------SKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNI 140
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1333 NTSANTRNDLLTILDTLTSKGN------LSLERLKQIKIPDIQILNEKvcgdpgnvpcvplpcggaLCTGRKGHRKCRgp 1406
Cdd:TIGR04523  141 DKFLTEIKKKEKELEKLNNKYNdlkkqkEELENELNLLEKEKLNIQKN------------------IDKIKNKLLKLE-- 200
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1407 gchgsLTLST--NALQKAQEAKSIIRNLDKQVRGLKNQIESisEQAEVSKNNAlQLREKLGNIRNQSDSEEENINLFIKK 1484
Cdd:TIGR04523  201 -----LLLSNlkKKIQKNKSLESQISELKKQNNQLKDNIEK--KQQEINEKTT-EISNTQTQLNQLKDEQNKIKKQLSEK 272
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1485 VKnflleenvppeDIEKvANGVLDihlpipsqNLTDELVKIQkhMQLcedyrtdENRLNEEADGAQKLLvkakaaekaAN 1564
Cdd:TIGR04523  273 QK-----------ELEQ-NNKKIK--------ELEKQLNQLK--SEI-------SDLNNQKEQDWNKEL---------KS 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1565 ILLNLDKTLNQLQQaQITQgrANSTITQLTANITKIKKNV--LQAENQT-----REMKSELE-LAKQRSG-------LED 1629
Cdd:TIGR04523  315 ELKNQEKKLEEIQN-QISQ--NNKIISQLNEQISQLKKELtnSESENSEkqrelEEKQNEIEkLKKENQSykqeiknLES 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1630 GLSLLQTKLQRHQDHAVNAKVQAESAQHQAGSLEKEFVELKKQyaILQRKTSTTGLTKE------TLGKVKQLKDAAEKL 1703
Cdd:TIGR04523  392 QINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKET--IIKNNSEIKDLTNQdsvkelIIKNLDNTRESLETQ 469
                          490
                   ....*....|.
gi 2462613137 1704 AGDTEAKIRRI 1714
Cdd:TIGR04523  470 LKVLSRSINKI 480
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
1080-1128 1.32e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 63.53  E-value: 1.32e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2462613137 1080 CDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRCIPC 1128
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
454-503 1.75e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 60.45  E-value: 1.75e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462613137  454 PCDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHGC 503
Cdd:cd00055      1 PCDCNGHGSLSG-QCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
505-549 3.79e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 59.68  E-value: 3.79e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2462613137  505 PCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLN 549
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQ 45
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
395-452 5.41e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 59.29  E-value: 5.41e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462613137  395 CECDPDGTiSGGICVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLSATDPLGC 452
Cdd:pfam00053    1 CDCNPHGS-LSDTCDPET--------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
1127-1165 2.36e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 57.36  E-value: 2.36e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462613137 1127 PCDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGH 1165
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGY 39
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
822-865 3.94e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 56.59  E-value: 3.94e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462613137  822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPSCHPCPC 865
Cdd:pfam00053    6 HGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
768-809 7.03e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.13  E-value: 7.03e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462613137  768 ACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDL 809
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGL 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
1033-1077 8.68e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 52.74  E-value: 8.68e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2462613137 1033 ECPPGGGACL-CDPVTGACPCLPNVTGLACDRCADGYWNLV--PGRGC 1077
Cdd:pfam00053    2 DCNPHGSLSDtCDPETGQCLCKPGVTGRHCDRCKPGYYGLPsdPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
862-909 9.99e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 50.05  E-value: 9.99e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462613137  862 PCPCNRFAEL---CDPETGSCFnCGGFTTGRNCERCIDGYYGNPSSGQPCR 909
Cdd:cd00055      1 PCDCNGHGSLsgqCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
264-320 8.72e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 47.35  E-value: 8.72e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137  264 SCFCNGHAS---ECRPmqkmrgdvfsppgmVHGQCVCQHNTDGPNCERCKDFFQDAPWRP 320
Cdd:cd00055      1 PCDCNGHGSlsgQCDP--------------GTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
970-1012 9.67e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 46.96  E-value: 9.67e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462613137  970 CACNNNIDVTDpeSCSRVTGECLrCLHNTQGANCQLCKPGHYG 1012
Cdd:pfam00053    1 CDCNPHGSLSD--TCDPETGQCL-CKPGVTGRHCDRCKPGYYG 40
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
332-382 8.05e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 44.65  E-value: 8.05e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462613137  332 CSCNSHSS---RCHFdmttylasgglSGGVCeDCQHNTEGQHCDRCRPLFYRDP 382
Cdd:pfam00053    1 CDCNPHGSlsdTCDP-----------ETGQC-LCKPGVTGRHCDRCKPGYYGLP 42
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
28-263 1.54e-94

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 304.89  E-value: 1.54e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137   28 CHPTTGDLLVGRntQLMASSTCGLSRAQKYCILSYLEGEQKCFICDSRFPYdpydqpNSHTIENVIvSFEPDREKKWWQS 107
Cdd:pfam00055    1 CYPAFGNLAFGR--EVSATSTCGLNGPERYCILSGLEGGKKCFICDSRDPH------NSHPPSNLT-DSNNGTNETWWQS 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137  108 ENGL---DHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAKDCATSFpNITSGQAQGVGD--IV 182
Cdd:pfam00055   72 ETGViqyENVNLTLDLGKEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTF-GRPSGPSRGIKDdeVI 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137  183 CDSKYSDIEPSTGGEVVLKVL--DPSFEIENpYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQndSLDKYYYALYEMI 260
Cdd:pfam00055  151 CTSEYSDISPLTGGEVIFSTLegRPSANIFD-YSPELQDWLTATNIRIRLLRLHTLGDELLDDPS--VLRKYYYAISDIS 227

                   ...
gi 2462613137  261 VRG 263
Cdd:pfam00055  228 VGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
23-263 4.49e-67

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 226.47  E-value: 4.49e-67
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137    23 CNRGACHPTTGDLLVGRntQLMASSTCGLSRAQKYCIL-SYLEGEQKCFICDSRFPYdpydqpNSHTIENVIVSFEPDRE 101
Cdd:smart00136    2 GRPRSCYPPFVNLAFGR--EVTATSTCGEPGPERYCKLvGHTEQGKKCDYCDARNPR------RSHPAENLTDGNNPNNP 73
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137   102 KkWWQSEN---GLDHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERStDYGHNWKVFKYFAKDCATSFPNITSG--QAQ 176
Cdd:smart00136   74 T-WWQSEPlsnGPQNVNLTLDLGKEFHVTYVILKFCSPRPSLWILERS-DFGKTWQPWQYFSSDCRRTFGRPPRGpiTKG 151
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137   177 GVGDIVCDSKYSDIEPSTGGEVVLKVLDPSFEIEN-PYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQNDsLDKYYYA 255
Cdd:smart00136  152 NEDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDfDNSPVLQEWVTATNIRVRLTRLRTLGDELMDDRPEV-TRRYYYA 230

                    ....*...
gi 2462613137   256 LYEMIVRG 263
Cdd:smart00136  231 ISDIAVGG 238
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
1254-1714 8.24e-13

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 73.52  E-value: 8.24e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1254 QIMQLNEQLKAV-YEFQDLKDTIERAKNEADLLLEDLqeeidlqsSVLNASIADSSENIKKYYHISSSAEKKINETSSTI 1332
Cdd:TIGR04523   69 KINNSNNKIKILeQQIKDLNDKLKKNKDKINKLNSDL--------SKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNI 140
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1333 NTSANTRNDLLTILDTLTSKGN------LSLERLKQIKIPDIQILNEKvcgdpgnvpcvplpcggaLCTGRKGHRKCRgp 1406
Cdd:TIGR04523  141 DKFLTEIKKKEKELEKLNNKYNdlkkqkEELENELNLLEKEKLNIQKN------------------IDKIKNKLLKLE-- 200
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1407 gchgsLTLST--NALQKAQEAKSIIRNLDKQVRGLKNQIESisEQAEVSKNNAlQLREKLGNIRNQSDSEEENINLFIKK 1484
Cdd:TIGR04523  201 -----LLLSNlkKKIQKNKSLESQISELKKQNNQLKDNIEK--KQQEINEKTT-EISNTQTQLNQLKDEQNKIKKQLSEK 272
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1485 VKnflleenvppeDIEKvANGVLDihlpipsqNLTDELVKIQkhMQLcedyrtdENRLNEEADGAQKLLvkakaaekaAN 1564
Cdd:TIGR04523  273 QK-----------ELEQ-NNKKIK--------ELEKQLNQLK--SEI-------SDLNNQKEQDWNKEL---------KS 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1565 ILLNLDKTLNQLQQaQITQgrANSTITQLTANITKIKKNV--LQAENQT-----REMKSELE-LAKQRSG-------LED 1629
Cdd:TIGR04523  315 ELKNQEKKLEEIQN-QISQ--NNKIISQLNEQISQLKKELtnSESENSEkqrelEEKQNEIEkLKKENQSykqeiknLES 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1630 GLSLLQTKLQRHQDHAVNAKVQAESAQHQAGSLEKEFVELKKQyaILQRKTSTTGLTKE------TLGKVKQLKDAAEKL 1703
Cdd:TIGR04523  392 QINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKET--IIKNNSEIKDLTNQdsvkelIIKNLDNTRESLETQ 469
                          490
                   ....*....|.
gi 2462613137 1704 AGDTEAKIRRI 1714
Cdd:TIGR04523  470 LKVLSRSINKI 480
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
1080-1128 1.32e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 63.53  E-value: 1.32e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2462613137 1080 CDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRCIPC 1128
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
454-503 1.75e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 60.45  E-value: 1.75e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462613137  454 PCDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHGC 503
Cdd:cd00055      1 PCDCNGHGSLSG-QCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1080-1125 3.61e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 59.63  E-value: 3.61e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2462613137  1080 CDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRC 1125
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
505-549 3.79e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 59.68  E-value: 3.79e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2462613137  505 PCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLN 549
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQ 45
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
395-452 5.41e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 59.29  E-value: 5.41e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462613137  395 CECDPDGTiSGGICVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLSATDPLGC 452
Cdd:pfam00053    1 CDCNPHGS-LSDTCDPET--------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
1079-1121 2.20e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 57.36  E-value: 2.20e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462613137 1079 SCDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDP 1121
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
455-508 2.23e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 57.36  E-value: 2.23e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462613137  455 CDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWGlgnhLHGCSPCDC 508
Cdd:pfam00053    1 CDCNPHGSLSD-TCDPETGQCLCKPGVTGRHCDRCKPGYYG----LPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
1127-1165 2.36e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 57.36  E-value: 2.36e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462613137 1127 PCDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGH 1165
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGY 39
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
822-865 3.94e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 56.59  E-value: 3.94e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462613137  822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPSCHPCPC 865
Cdd:pfam00053    6 HGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
506-549 6.58e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.78  E-value: 6.58e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462613137   506 CDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLN 549
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP 44
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1128-1172 9.27e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.40  E-value: 9.27e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2462613137  1128 CDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGHSQE-FPTC 1172
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDgPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
394-453 2.69e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 54.28  E-value: 2.69e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137  394 PCECDPDGTISGGiCVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLsATDPLGCQ 453
Cdd:cd00055      1 PCDCNGHGSLSGQ-CDPGT--------GQCECKPNTTGRRCDRCAPGYYGL-PSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
1128-1165 3.53e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.90  E-value: 3.53e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462613137 1128 CDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGH 1165
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGY 38
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
455-503 4.02e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 53.85  E-value: 4.02e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2462613137   455 CDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWglGNHLHGC 503
Cdd:smart00180    1 CDCDPGGSASG-TCDPDTGQCECKPNVTGRRCDRCAPGYY--GDGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
768-809 7.03e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.13  E-value: 7.03e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462613137  768 ACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDL 809
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGL 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
769-809 7.21e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.13  E-value: 7.21e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462613137  769 CKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDL 809
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGL 41
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
1033-1077 8.68e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 52.74  E-value: 8.68e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2462613137 1033 ECPPGGGACL-CDPVTGACPCLPNVTGLACDRCADGYWNLV--PGRGC 1077
Cdd:pfam00053    2 DCNPHGSLSDtCDPETGQCLCKPGVTGRHCDRCKPGYYGLPsdPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
1021-1078 1.19e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 52.36  E-value: 1.19e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462613137 1021 RCSCHASGVSPMECppgggaclcDPVTGACPCLPNVTGLACDRCADGYWNL-VPGRGCQ 1078
Cdd:cd00055      1 PCDCNGHGSLSGQC---------DPGTGQCECKPNTTGRRCDRCAPGYYGLpSQGGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
822-859 2.61e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 51.59  E-value: 2.61e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462613137  822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPS 859
Cdd:cd00055      7 HGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1022-1077 2.88e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 51.16  E-value: 2.88e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462613137  1022 CSCHASGVSPMECppgggaclcDPVTGACPCLPNVTGLACDRCADGYWNlVPGRGC 1077
Cdd:smart00180    1 CDCDPGGSASGTC---------DPDTGQCECKPNVTGRRCDRCAPGYYG-DGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
395-448 4.02e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 50.77  E-value: 4.02e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2462613137   395 CECDPDGTISGGiCVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLSATD 448
Cdd:smart00180    1 CDCDPGGSASGT-CDPDT--------GQCECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
862-909 9.99e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 50.05  E-value: 9.99e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462613137  862 PCPCNRFAEL---CDPETGSCFnCGGFTTGRNCERCIDGYYGNPSSGQPCR 909
Cdd:cd00055      1 PCDCNGHGSLsgqCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
769-808 1.23e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 49.62  E-value: 1.23e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2462613137   769 CKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYD 808
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYG 40
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
822-860 3.94e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 48.08  E-value: 3.94e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462613137   822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFG--FPSC 860
Cdd:smart00180    6 GGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGdgPPGC 46
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1566-1714 5.11e-07

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 54.14  E-value: 5.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1566 LLNLDKTLNQLQQAQitqgranstitqltANITKIKKNVLQAENQTREMKSELELAKQRsgledgLSLLQTKLQRHQDHA 1645
Cdd:COG4372     37 LFELDKLQEELEQLR--------------EELEQAREELEQLEEELEQARSELEQLEEE------LEELNEQLQAAQAEL 96
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462613137 1646 VNAKVQAESAQHQAGSLEKEFVELKKQYAILQRKTST-----TGLTKETLGKVKQLKDAAEKLAgDTEAKIRRI 1714
Cdd:COG4372     97 AQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQleaqiAELQSEIAEREEELKELEEQLE-SLQEELAAL 169
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
264-320 8.72e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 47.35  E-value: 8.72e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137  264 SCFCNGHAS---ECRPmqkmrgdvfsppgmVHGQCVCQHNTDGPNCERCKDFFQDAPWRP 320
Cdd:cd00055      1 PCDCNGHGSlsgQCDP--------------GTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
970-1012 9.67e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 46.96  E-value: 9.67e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462613137  970 CACNNNIDVTDpeSCSRVTGECLrCLHNTQGANCQLCKPGHYG 1012
Cdd:pfam00053    1 CDCNPHGSLSD--TCDPETGQCL-CKPGVTGRHCDRCKPGYYG 40
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
969-1020 1.33e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.58  E-value: 1.33e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462613137  969 PCACNNNIDVtdPESCSRVTGECLrCLHNTQGANCQLCKPGHYGSALN-QTCR 1020
Cdd:cd00055      1 PCDCNGHGSL--SGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQgGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
506-544 2.34e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 46.19  E-value: 2.34e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462613137  506 CDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYF 544
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYY 39
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
332-382 8.05e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 44.65  E-value: 8.05e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462613137  332 CSCNSHSS---RCHFdmttylasgglSGGVCeDCQHNTEGQHCDRCRPLFYRDP 382
Cdd:pfam00053    1 CDCNPHGSlsdTCDP-----------ETGQC-LCKPGVTGRHCDRCKPGYYGLP 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
331-384 1.19e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 43.88  E-value: 1.19e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462613137  331 SCSCNSHSS---RCHFDmttylasgglsGGVCEdCQHNTEGQHCDRCRPLFYRDPLK 384
Cdd:cd00055      1 PCDCNGHGSlsgQCDPG-----------TGQCE-CKPNTTGRRCDRCAPGYYGLPSQ 45
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
863-908 4.96e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 42.34  E-value: 4.96e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462613137  863 CPCN---RFAELCDPETGSCFnCGGFTTGRNCERCIDGYYGNPS-SGQPC 908
Cdd:pfam00053    1 CDCNphgSLSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSdPPQGC 49
46 PHA02562
endonuclease subunit; Provisional
1413-1639 9.48e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 47.32  E-value: 9.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1413 TLST-NALQKAQ--EAKSIIRNLDKQVRGLKNQIES----ISEQAEVSKNNALQLREKLGNIRNQSDSEEENINLFIKKV 1485
Cdd:PHA02562   164 VLSEmDKLNKDKirELNQQIQTLDMKIDHIQQQIKTynknIEEQRKKNGENIARKQNKYDELVEEAKTIKAEIEELTDEL 243
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1486 KNFLLEENVPPEDIEKVANGVLDIHLPIpsQNLTDELVKIQKHmQLC----EDYRTDENRLneeADGAQKLLVKAKAAEK 1561
Cdd:PHA02562   244 LNLVMDIEDPSAALNKLNTAAAKIKSKI--EQFQKVIKMYEKG-GVCptctQQISEGPDRI---TKIKDKLKELQHSLEK 317
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462613137 1562 AANILLNLDKTLNQLQQAQitqgranSTITQLTANITKIKKNVLQAENQTREMKSELE-LAKQRSGLEDGLSLLQTKLQ 1639
Cdd:PHA02562   318 LDTAIDELEEIMDEFNEQS-------KKLLELKNKISTNKQSLITLVDKAKKVKAAIEeLQAEFVDNAEELAKLQDELD 389
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
332-382 2.15e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 40.37  E-value: 2.15e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2462613137   332 CSCN---SHSSRCHFDmttylasgglsGGVCEdCQHNTEGQHCDRCRPLFYRDP 382
Cdd:smart00180    1 CDCDpggSASGTCDPD-----------TGQCE-CKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
863-905 2.65e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 39.99  E-value: 2.65e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2462613137   863 CPCNR---FAELCDPETGSCfNCGGFTTGRNCERCIDGYYGNPSSG 905
Cdd:smart00180    1 CDCDPggsASGTCDPDTGQC-ECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
970-1013 2.67e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 39.99  E-value: 2.67e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462613137   970 CACNNniDVTDPESCSRVTGECLrCLHNTQGANCQLCKPGHYGS 1013
Cdd:smart00180    1 CDCDP--GGSASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD 41
cc_LAMB4_C cd22301
C-terminal coiled-coil domain found in laminin subunit beta-4 (LAMB4); LAMB4, also called ...
1690-1715 3.30e-04

C-terminal coiled-coil domain found in laminin subunit beta-4 (LAMB4); LAMB4, also called laminin beta-1-related protein, is a component of laminin, a complex glycoprotein consisting of three different polypeptide chains (alpha, beta, gamma). Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Mutations or loss of LAMB4 may be features of gastric and colorectal cancers. Reduced LAMB4 levels may contribute to colonic dysmotility associated with diverticulitis. This model corresponds to the C-terminal coiled-coil domain of LAMB4, which may be involved in the integrin binding activity.


Pssm-ID: 411972 [Multi-domain]  Cd Length: 70  Bit Score: 40.80  E-value: 3.30e-04
                           10        20
                   ....*....|....*....|....*.
gi 2462613137 1690 LGKVKQLKDAAEKLAGDTEAKIRRIT 1715
Cdd:cd22301      1 NERLKNIKKEAENLAKEIEDKMKRIE 26
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
265-323 4.40e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 39.64  E-value: 4.40e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462613137  265 CFCNGHAS---ECRPMQkmrgdvfsppgmvhGQCVCQHNTDGPNCERCKDFFQDAPWRPAAD 323
Cdd:pfam00053    1 CDCNPHGSlsdTCDPET--------------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQG 48
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
291-313 8.13e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 38.83  E-value: 8.13e-04
                            10        20
                    ....*....|....*....|...
gi 2462613137   291 VHGQCVCQHNTDGPNCERCKDFF 313
Cdd:smart00180   16 DTGQCECKPNVTGRRCDRCAPGY 38
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
28-263 1.54e-94

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 304.89  E-value: 1.54e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137   28 CHPTTGDLLVGRntQLMASSTCGLSRAQKYCILSYLEGEQKCFICDSRFPYdpydqpNSHTIENVIvSFEPDREKKWWQS 107
Cdd:pfam00055    1 CYPAFGNLAFGR--EVSATSTCGLNGPERYCILSGLEGGKKCFICDSRDPH------NSHPPSNLT-DSNNGTNETWWQS 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137  108 ENGL---DHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAKDCATSFpNITSGQAQGVGD--IV 182
Cdd:pfam00055   72 ETGViqyENVNLTLDLGKEFHFTYLILKFKSPRPAAMVLERSTDFGKTWQPYQYFASDCRRTF-GRPSGPSRGIKDdeVI 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137  183 CDSKYSDIEPSTGGEVVLKVL--DPSFEIENpYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQndSLDKYYYALYEMI 260
Cdd:pfam00055  151 CTSEYSDISPLTGGEVIFSTLegRPSANIFD-YSPELQDWLTATNIRIRLLRLHTLGDELLDDPS--VLRKYYYAISDIS 227

                   ...
gi 2462613137  261 VRG 263
Cdd:pfam00055  228 VGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
23-263 4.49e-67

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 226.47  E-value: 4.49e-67
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137    23 CNRGACHPTTGDLLVGRntQLMASSTCGLSRAQKYCIL-SYLEGEQKCFICDSRFPYdpydqpNSHTIENVIVSFEPDRE 101
Cdd:smart00136    2 GRPRSCYPPFVNLAFGR--EVTATSTCGEPGPERYCKLvGHTEQGKKCDYCDARNPR------RSHPAENLTDGNNPNNP 73
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137   102 KkWWQSEN---GLDHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERStDYGHNWKVFKYFAKDCATSFPNITSG--QAQ 176
Cdd:smart00136   74 T-WWQSEPlsnGPQNVNLTLDLGKEFHVTYVILKFCSPRPSLWILERS-DFGKTWQPWQYFSSDCRRTFGRPPRGpiTKG 151
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137   177 GVGDIVCDSKYSDIEPSTGGEVVLKVLDPSFEIEN-PYSPYIQDLVTLTNLRINFTKLHTLGDALLGRRQNDsLDKYYYA 255
Cdd:smart00136  152 NEDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDfDNSPVLQEWVTATNIRVRLTRLRTLGDELMDDRPEV-TRRYYYA 230

                    ....*...
gi 2462613137   256 LYEMIVRG 263
Cdd:smart00136  231 ISDIAVGG 238
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
1254-1714 8.24e-13

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 73.52  E-value: 8.24e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1254 QIMQLNEQLKAV-YEFQDLKDTIERAKNEADLLLEDLqeeidlqsSVLNASIADSSENIKKYYHISSSAEKKINETSSTI 1332
Cdd:TIGR04523   69 KINNSNNKIKILeQQIKDLNDKLKKNKDKINKLNSDL--------SKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNI 140
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1333 NTSANTRNDLLTILDTLTSKGN------LSLERLKQIKIPDIQILNEKvcgdpgnvpcvplpcggaLCTGRKGHRKCRgp 1406
Cdd:TIGR04523  141 DKFLTEIKKKEKELEKLNNKYNdlkkqkEELENELNLLEKEKLNIQKN------------------IDKIKNKLLKLE-- 200
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1407 gchgsLTLST--NALQKAQEAKSIIRNLDKQVRGLKNQIESisEQAEVSKNNAlQLREKLGNIRNQSDSEEENINLFIKK 1484
Cdd:TIGR04523  201 -----LLLSNlkKKIQKNKSLESQISELKKQNNQLKDNIEK--KQQEINEKTT-EISNTQTQLNQLKDEQNKIKKQLSEK 272
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1485 VKnflleenvppeDIEKvANGVLDihlpipsqNLTDELVKIQkhMQLcedyrtdENRLNEEADGAQKLLvkakaaekaAN 1564
Cdd:TIGR04523  273 QK-----------ELEQ-NNKKIK--------ELEKQLNQLK--SEI-------SDLNNQKEQDWNKEL---------KS 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1565 ILLNLDKTLNQLQQaQITQgrANSTITQLTANITKIKKNV--LQAENQT-----REMKSELE-LAKQRSG-------LED 1629
Cdd:TIGR04523  315 ELKNQEKKLEEIQN-QISQ--NNKIISQLNEQISQLKKELtnSESENSEkqrelEEKQNEIEkLKKENQSykqeiknLES 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1630 GLSLLQTKLQRHQDHAVNAKVQAESAQHQAGSLEKEFVELKKQyaILQRKTSTTGLTKE------TLGKVKQLKDAAEKL 1703
Cdd:TIGR04523  392 QINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKET--IIKNNSEIKDLTNQdsvkelIIKNLDNTRESLETQ 469
                          490
                   ....*....|.
gi 2462613137 1704 AGDTEAKIRRI 1714
Cdd:TIGR04523  470 LKVLSRSINKI 480
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
1080-1128 1.32e-12

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 63.53  E-value: 1.32e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2462613137 1080 CDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRCIPC 1128
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
454-503 1.75e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 60.45  E-value: 1.75e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462613137  454 PCDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHGC 503
Cdd:cd00055      1 PCDCNGHGSLSG-QCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1080-1125 3.61e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 59.63  E-value: 3.61e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2462613137  1080 CDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRC 1125
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
505-549 3.79e-11

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 59.68  E-value: 3.79e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2462613137  505 PCDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLN 549
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQ 45
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
395-452 5.41e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 59.29  E-value: 5.41e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462613137  395 CECDPDGTiSGGICVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLSATDPLGC 452
Cdd:pfam00053    1 CDCNPHGS-LSDTCDPET--------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
1079-1121 2.20e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 57.36  E-value: 2.20e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462613137 1079 SCDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDP 1121
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
455-508 2.23e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 57.36  E-value: 2.23e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462613137  455 CDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWGlgnhLHGCSPCDC 508
Cdd:pfam00053    1 CDCNPHGSLSD-TCDPETGQCLCKPGVTGRHCDRCKPGYYG----LPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
1127-1165 2.36e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 57.36  E-value: 2.36e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462613137 1127 PCDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGH 1165
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGY 39
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
822-865 3.94e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 56.59  E-value: 3.94e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462613137  822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPSCHPCPC 865
Cdd:pfam00053    6 HGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
506-549 6.58e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.78  E-value: 6.58e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462613137   506 CDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYFFAPLN 549
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP 44
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1128-1172 9.27e-10

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 55.40  E-value: 9.27e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2462613137  1128 CDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGHSQE-FPTC 1172
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDgPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
394-453 2.69e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 54.28  E-value: 2.69e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137  394 PCECDPDGTISGGiCVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLsATDPLGCQ 453
Cdd:cd00055      1 PCDCNGHGSLSGQ-CDPGT--------GQCECKPNTTGRRCDRCAPGYYGL-PSQGGGCQ 50
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
1253-1698 3.28e-09

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 61.96  E-value: 3.28e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1253 RQIMQLNEQLkavyefQDLKDTIERAKNEADL-LLEDLQEEIDlqssvlnaSIADSSENIKKyyHISSSaEKKINETSST 1331
Cdd:TIGR04523  281 KKIKELEKQL------NQLKSEISDLNNQKEQdWNKELKSELK--------NQEKKLEEIQN--QISQN-NKIISQLNEQ 343
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1332 INTSANTRNDLltilDTLTSKGNLSLERlKQIKIpdIQILNEKvcgdpgnvpcvplpcggalcTGRKGHRKcrgpgchgS 1411
Cdd:TIGR04523  344 ISQLKKELTNS----ESENSEKQRELEE-KQNEI--EKLKKEN--------------------QSYKQEIK--------N 388
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1412 LTLSTNAL-QKAQEAKSIIRNLDKQVRGLKNQIESISEQAEVSKNNALQLREKLGNIRNQsDSEEENInlfIKKVKNFLL 1490
Cdd:TIGR04523  389 LESQINDLeSKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQ-DSVKELI---IKNLDNTRE 464
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1491 EENVPPEDIEKVANGvLDIHLPIPSQNLTDelvKIQKHMQLcedyrTDENRLNEEadgaqKLlvkakaaekaanillnld 1570
Cdd:TIGR04523  465 SLETQLKVLSRSINK-IKQNLEQKQKELKS---KEKELKKL-----NEEKKELEE-----KV------------------ 512
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1571 KTLNQlQQAQItqgraNSTITQLTANITKIKKNVLQAENQTREMKSEL---ELAKQRSG--------------LEDGLSL 1633
Cdd:TIGR04523  513 KDLTK-KISSL-----KEKIEKLESEKKEKESKISDLEDELNKDDFELkkeNLEKEIDEknkeieelkqtqksLKKKQEE 586
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462613137 1634 LQTKLQRHQDHAVNAKVQAESAQHQAGSLEKEFVELKKQYAILQRKTSTTGLTKETLGK-VKQLKD 1698
Cdd:TIGR04523  587 KQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQeVKQIKE 652
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
1128-1165 3.53e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.90  E-value: 3.53e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462613137 1128 CDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRCARGH 1165
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGY 38
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
455-503 4.02e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 53.85  E-value: 4.02e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 2462613137   455 CDCNPLGSLPFlTCDVDTGQCLCLSYVTGAHCEECTVGYWglGNHLHGC 503
Cdd:smart00180    1 CDCDPGGSASG-TCDPDTGQCECKPNVTGRRCDRCAPGYY--GDGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
768-809 7.03e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.13  E-value: 7.03e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2462613137  768 ACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDL 809
Cdd:cd00055      1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGL 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
769-809 7.21e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.13  E-value: 7.21e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462613137  769 CKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDL 809
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGL 41
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
1033-1077 8.68e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 52.74  E-value: 8.68e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 2462613137 1033 ECPPGGGACL-CDPVTGACPCLPNVTGLACDRCADGYWNLV--PGRGC 1077
Cdd:pfam00053    2 DCNPHGSLSDtCDPETGQCLCKPGVTGRHCDRCKPGYYGLPsdPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
1021-1078 1.19e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 52.36  E-value: 1.19e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462613137 1021 RCSCHASGVSPMECppgggaclcDPVTGACPCLPNVTGLACDRCADGYWNL-VPGRGCQ 1078
Cdd:cd00055      1 PCDCNGHGSLSGQC---------DPGTGQCECKPNTTGRRCDRCAPGYYGLpSQGGGCQ 50
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
1223-1714 2.23e-08

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 59.68  E-value: 2.23e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1223 NVSEIERILKHPVFPS-GK--FLKVKDYHDSVRRQIMQLNEQL-KAVYEFQDLKDTIERAKNEADLLLEDLQEEIDlqss 1298
Cdd:TIGR01612 1085 NFNEIKEKLKHYNFDDfGKeeNIKYADEINKIKDDIKNLDQKIdHHIKALEEIKKKSENYIDEIKAQINDLEDVAD---- 1160
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1299 vlnasIADSSENIKKYyhisssaEKKINETSSTINTSANTRNDLLTILDTLT--SKGNLSLERLKQIKIPDIQILNEkvc 1376
Cdd:TIGR01612 1161 -----KAISNDDPEEI-------EKKIENIVTKIDKKKNIYDEIKKLLNEIAeiEKDKTSLEEVKGINLSYGKNLGK--- 1225
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1377 gdpgnvpcvplpcggaLCTGRKGHRKCRGPGCHGSLTLSTNALQKAQEAKSIIRNLDKQVRGLKNQIE--SISEQAE--- 1451
Cdd:TIGR01612 1226 ----------------LFLEKIDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEIENEMGIEMDIKAEMEtfNISHDDDkdh 1289
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1452 --VSKNNalqlREKLGNIRNQS------DSEEENINLFIKKVKNFLLEENVPPEDIEKVANGVLDIHLPIPSQNLTDELV 1523
Cdd:TIGR01612 1290 hiISKKH----DENISDIREKSlkiiedFSEESDINDIKKELQKNLLDAQKHNSDINLYLNEIANIYNILKLNKIKKIID 1365
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1524 KIQKHMQLCEDYRTDenrLNEEADGAQKLLVKAKAAEKAANILLNLDKTLNQ------LQQAQITQgraNSTITQLTANI 1597
Cdd:TIGR01612 1366 EVKEYTKEIEENNKN---IKDELDKSEKLIKKIKDDINLEECKSKIESTLDDkdidecIKKIKELK---NHILSEESNID 1439
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1598 TKIK------KNVLQAENQTrEM---KSELELAKQRSGLEDGLSLLQTKLQRHQDHAVNAKVQAESAQHQA-------GS 1661
Cdd:TIGR01612 1440 TYFKnadennENVLLLFKNI-EMadnKSQHILKIKKDNATNDHDFNINELKEHIDKSKGCKDEADKNAKAIeknkelfEQ 1518
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462613137 1662 LEKEFVELKKQYAILQRKTSTTGLTKETLGKVKQLKDAAEKL---AGDTEAKIRRI 1714
Cdd:TIGR01612 1519 YKKDVTELLNKYSALAIKNKFAKTKKDSEIIIKEIKDAHKKFileAEKSEQKIKEI 1574
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
822-859 2.61e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 51.59  E-value: 2.61e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462613137  822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPS 859
Cdd:cd00055      7 HGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1022-1077 2.88e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 51.16  E-value: 2.88e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462613137  1022 CSCHASGVSPMECppgggaclcDPVTGACPCLPNVTGLACDRCADGYWNlVPGRGC 1077
Cdd:smart00180    1 CDCDPGGSASGTC---------DPDTGQCECKPNVTGRRCDRCAPGYYG-DGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
395-448 4.02e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 50.77  E-value: 4.02e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2462613137   395 CECDPDGTISGGiCVSHSdpalgsvaGQCLCKENVEGAKCDQCKPNHYGLSATD 448
Cdd:smart00180    1 CDCDPGGSASGT-CDPDT--------GQCECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
862-909 9.99e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 50.05  E-value: 9.99e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462613137  862 PCPCNRFAEL---CDPETGSCFnCGGFTTGRNCERCIDGYYGNPSSGQPCR 909
Cdd:cd00055      1 PCDCNGHGSLsgqCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
769-808 1.23e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 49.62  E-value: 1.23e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2462613137   769 CKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYD 808
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYG 40
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
822-860 3.94e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 48.08  E-value: 3.94e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462613137   822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFG--FPSC 860
Cdd:smart00180    6 GGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGdgPPGC 46
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1566-1714 5.11e-07

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 54.14  E-value: 5.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1566 LLNLDKTLNQLQQAQitqgranstitqltANITKIKKNVLQAENQTREMKSELELAKQRsgledgLSLLQTKLQRHQDHA 1645
Cdd:COG4372     37 LFELDKLQEELEQLR--------------EELEQAREELEQLEEELEQARSELEQLEEE------LEELNEQLQAAQAEL 96
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462613137 1646 VNAKVQAESAQHQAGSLEKEFVELKKQYAILQRKTST-----TGLTKETLGKVKQLKDAAEKLAgDTEAKIRRI 1714
Cdd:COG4372     97 AQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQleaqiAELQSEIAEREEELKELEEQLE-SLQEELAAL 169
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
1250-1495 7.87e-07

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 53.81  E-value: 7.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1250 SVRRQIMQLNEQLKAVYEFQdlkdTIERAKNEADLLLEDLQEEIDLQSSVLNASIADSSENIKKYYHIS--SSAEKKINE 1327
Cdd:COG5185    306 DIKKATESLEEQLAAAEAEQ----ELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVelSKSSEELDS 381
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1328 TSSTINTsanTRNDLLTILDTLTSKGNLSLERL-KQIKIPDIQI--LNEKVCGDPGNVPCVPLPCGGALCTGRKGHRKCR 1404
Cdd:COG5185    382 FKDTIES---TKESLDEIPQNQRGYAQEILATLeDTLKAADRQIeeLQRQIEQATSSNEEVSKLLNELISELNKVMREAD 458
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1405 GpgchGSLTLSTNALQK-AQEAKSIIRNLDKQVRGLKNQIESISEQAEVSKNNalqLREKLGNIRNQSDSEEENINLFIK 1483
Cdd:COG5185    459 E----ESQSRLEEAYDEiNRSVRSKKEDLNEELTQIESRVSTLKATLEKLRAK---LERQLEGVRSKLDQVAESLKDFMR 531
                          250
                   ....*....|..
gi 2462613137 1484 KVKNFLLEENVP 1495
Cdd:COG5185    532 ARGYAHILALEN 543
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
1426-1703 8.30e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 53.87  E-value: 8.30e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1426 KSIIRNLDKQVRGLKNQIESISEQAEVSKNnalqlreKLGNIRNQSDSEEENINLFIKKVKNflLEENVppEDI---EKV 1502
Cdd:TIGR04523   25 KNIANKQDTEEKQLEKKLKTIKNELKNKEK-------ELKNLDKNLNKDEEKINNSNNKIKI--LEQQI--KDLndkLKK 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1503 ANGVLDihlpipsqNLTDELVKIQKHMQLCEDY----RTDENRLNEEADGAQKLLvkakaaEKAANILLNLDKTLNQLqq 1578
Cdd:TIGR04523   94 NKDKIN--------KLNSDLSKINSEIKNDKEQknklEVELNKLEKQKKENKKNI------DKFLTEIKKKEKELEKL-- 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1579 aqitqgraNSTITQLTANITKIKKNVLQAENQTREMKSELELAK-QRSGLEDGLSLLQTKLQRHQdhavnakvqaesaqh 1657
Cdd:TIGR04523  158 --------NNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKnKLLKLELLLSNLKKKIQKNK--------------- 214
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 2462613137 1658 qagSLEKEFVELKKQYAILqrKTSTTGLTKETLGKVKQLKDAAEKL 1703
Cdd:TIGR04523  215 ---SLESQISELKKQNNQL--KDNIEKKQQEINEKTTEISNTQTQL 255
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
264-320 8.72e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 47.35  E-value: 8.72e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137  264 SCFCNGHAS---ECRPmqkmrgdvfsppgmVHGQCVCQHNTDGPNCERCKDFFQDAPWRP 320
Cdd:cd00055      1 PCDCNGHGSlsgQCDP--------------GTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
970-1012 9.67e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 46.96  E-value: 9.67e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462613137  970 CACNNNIDVTDpeSCSRVTGECLrCLHNTQGANCQLCKPGHYG 1012
Cdd:pfam00053    1 CDCNPHGSLSD--TCDPETGQCL-CKPGVTGRHCDRCKPGYYG 40
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
969-1020 1.33e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 46.58  E-value: 1.33e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462613137  969 PCACNNNIDVtdPESCSRVTGECLrCLHNTQGANCQLCKPGHYGSALN-QTCR 1020
Cdd:cd00055      1 PCDCNGHGSL--SGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQgGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
506-544 2.34e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 46.19  E-value: 2.34e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2462613137  506 CDCDIGGAYSNVCSPKNGQCECRPHVTGRSCSEPAPGYF 544
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYY 39
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
1241-1712 6.52e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 51.12  E-value: 6.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1241 FLKVKDYHDSVRRQIMQLNEQLKAVYE-FQDLKDTIERAKNEADLLLEDLQEEIDLQSSVLNA---------SIADSSEN 1310
Cdd:TIGR00618  367 IREISCQQHTLTQHIHTLQQQKTTLTQkLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAkkqqelqqrYAELCAAA 446
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1311 IKKYYHISSSAEKKINETSSTINTSANTRNDLLTILDTLTSKGNLSLERLKQIKipDIQILNEKVCGDPgNVPCVPLPCG 1390
Cdd:TIGR00618  447 ITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQ--EEPCPLCGSCIHP-NPARQDIDNP 523
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1391 GALCTgrkghRKCRGpgchgsltlstnaLQKAQEAKSIIRNLDKQVRGLKNQIESISEQAEvsknNALQLREKLGNIRNQ 1470
Cdd:TIGR00618  524 GPLTR-----RMQRG-------------EQTYAQLETSEEDVYHQLTSERKQRASLKEQMQ----EIQQSFSILTQCDNR 581
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1471 SDseeeninlfikkvknflleenvppEDIEKVANGVLDIhlpipsQNLTDELVKIQKhMQLCEDYRtDENRLNEEADGAQ 1550
Cdd:TIGR00618  582 SK------------------------EDIPNLQNITVRL------QDLTEKLSEAED-MLACEQHA-LLRKLQPEQDLQD 629
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1551 KLLVKAKAAEKAANILLNLDKTLNQLQQAQITQGRANSTITQltanitkiKKNVLQAENQTREMKSELE-LAKQRSGLED 1629
Cdd:TIGR00618  630 VRLHLQQCSQELALKLTALHALQLTLTQERVREHALSIRVLP--------KELLASRQLALQKMQSEKEqLTYWKEMLAQ 701
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1630 GLSLLQTKLQ--------RHQ----DHAVNAKVQAE--SAQHQAGSLEKEFVE-LKKQYAILQRKTsttgltkETLGKVK 1694
Cdd:TIGR00618  702 CQTLLRELEThieeydreFNEienaSSSLGSDLAARedALNQSLKELMHQARTvLKARTEAHFNNN-------EEVTAAL 774
                          490
                   ....*....|....*...
gi 2462613137 1695 QLKDAAEKLAGDTEAKIR 1712
Cdd:TIGR00618  775 QTGAELSHLAAEIQFFNR 792
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
332-382 8.05e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 44.65  E-value: 8.05e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462613137  332 CSCNSHSS---RCHFdmttylasgglSGGVCeDCQHNTEGQHCDRCRPLFYRDP 382
Cdd:pfam00053    1 CDCNPHGSlsdTCDP-----------ETGQC-LCKPGVTGRHCDRCKPGYYGLP 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
331-384 1.19e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 43.88  E-value: 1.19e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462613137  331 SCSCNSHSS---RCHFDmttylasgglsGGVCEdCQHNTEGQHCDRCRPLFYRDPLK 384
Cdd:cd00055      1 PCDCNGHGSlsgQCDPG-----------TGQCE-CKPNTTGRRCDRCAPGYYGLPSQ 45
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1418-1716 1.71e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 49.13  E-value: 1.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1418 ALQKAQEAKSIIRNLDKQVRGLKNQIESISEQAEVSKNNALQLREKLGNIRNQSDSEEENINLFIKKVKNFLLEENVPPE 1497
Cdd:COG4372     36 ALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQE 115
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1498 DIEKVANGVldihlpipsQNLTDELVKI-QKHMQLCEDYRTDENRLNEeadgaqkllvkakaaekaanillnLDKTLNQL 1576
Cdd:COG4372    116 ELEELQKER---------QDLEQQRKQLeAQIAELQSEIAEREEELKE------------------------LEEQLESL 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1577 QQ--AQITQGRANSTITQLTANITKIKKNVLQAENQTREMKSELELAKQRSGLEDGLSLLQTKLQRHQdHAVNAKVQAES 1654
Cdd:COG4372    163 QEelAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAK-LGLALSALLDA 241
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462613137 1655 AQHQAGSLEKEFVELKKQYAILQRKTSTTGLTKETLGKVKQLKDAAEKLAGDTEAKIRRITG 1716
Cdd:COG4372    242 LELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLN 303
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
863-908 4.96e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 42.34  E-value: 4.96e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462613137  863 CPCN---RFAELCDPETGSCFnCGGFTTGRNCERCIDGYYGNPS-SGQPC 908
Cdd:pfam00053    1 CDCNphgSLSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSdPPQGC 49
46 PHA02562
endonuclease subunit; Provisional
1413-1639 9.48e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 47.32  E-value: 9.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1413 TLST-NALQKAQ--EAKSIIRNLDKQVRGLKNQIES----ISEQAEVSKNNALQLREKLGNIRNQSDSEEENINLFIKKV 1485
Cdd:PHA02562   164 VLSEmDKLNKDKirELNQQIQTLDMKIDHIQQQIKTynknIEEQRKKNGENIARKQNKYDELVEEAKTIKAEIEELTDEL 243
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1486 KNFLLEENVPPEDIEKVANGVLDIHLPIpsQNLTDELVKIQKHmQLC----EDYRTDENRLneeADGAQKLLVKAKAAEK 1561
Cdd:PHA02562   244 LNLVMDIEDPSAALNKLNTAAAKIKSKI--EQFQKVIKMYEKG-GVCptctQQISEGPDRI---TKIKDKLKELQHSLEK 317
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462613137 1562 AANILLNLDKTLNQLQQAQitqgranSTITQLTANITKIKKNVLQAENQTREMKSELE-LAKQRSGLEDGLSLLQTKLQ 1639
Cdd:PHA02562   318 LDTAIDELEEIMDEFNEQS-------KKLLELKNKISTNKQSLITLVDKAKKVKAAIEeLQAEFVDNAEELAKLQDELD 389
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
1516-1690 1.85e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 46.50  E-value: 1.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1516 QNLTDELVKI---QKHMQLCEDYRTDENRLNEEADGAQKLLvkaKAAEKAANILLNLDKTLnQLQQAQITQGRANSTITQ 1592
Cdd:TIGR00618  222 QVLEKELKHLreaLQQTQQSHAYLTQKREAQEEQLKKQQLL---KQLRARIEELRAQEAVL-EETQERINRARKAAPLAA 297
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1593 LTANITKIKKNVLQAENQTREMKSELE--------LAKQRSGLEDGLSLLQTKLQRHQDHAVNAKVQAESAQH--QAGSL 1662
Cdd:TIGR00618  298 HIKAVTQIEQQAQRIHTELQSKMRSRAkllmkraaHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREIscQQHTL 377
                          170       180
                   ....*....|....*....|....*...
gi 2462613137 1663 EKEFVELKKQYAILQRKTSTTGLTKETL 1690
Cdd:TIGR00618  378 TQHIHTLQQQKTTLTQKLQSLCKELDIL 405
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
332-382 2.15e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 40.37  E-value: 2.15e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2462613137   332 CSCN---SHSSRCHFDmttylasgglsGGVCEdCQHNTEGQHCDRCRPLFYRDP 382
Cdd:smart00180    1 CDCDpggSASGTCDPD-----------TGQCE-CKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
863-905 2.65e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 39.99  E-value: 2.65e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 2462613137   863 CPCNR---FAELCDPETGSCfNCGGFTTGRNCERCIDGYYGNPSSG 905
Cdd:smart00180    1 CDCDPggsASGTCDPDTGQC-ECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
970-1013 2.67e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 39.99  E-value: 2.67e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2462613137   970 CACNNniDVTDPESCSRVTGECLrCLHNTQGANCQLCKPGHYGS 1013
Cdd:smart00180    1 CDCDP--GGSASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD 41
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
1257-1625 3.22e-04

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 45.98  E-value: 3.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1257 QLNEQLKavyEFQDLKDTIERAKNEADLLLEDLQEE-----IDLQSSVLNASIADSSENIKKYYHiSSSAEKKINETSST 1331
Cdd:PTZ00440  1177 QINNEAK---KSKTIMEEIESYKKDIDQVKKNMSKErndhlTTFEYNAYYDKATASYENIEELTT-EAKGLKGEANRSTN 1252
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1332 INTSANTRNDLLTILDTLTSKGNLSLERLKQIK-IPDIQILN--EKVCGDPGNVpcvplpcggalctgrkghrkcrgpgc 1408
Cdd:PTZ00440  1253 VDELKEIKLQVFSYLQQVIKENNKMENALHEIKnMYEFLISIdsEKILKEILNS-------------------------- 1306
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1409 hgsltlSTNALQKAQEAKSIirnLDKQVRgLKNQIESISEQAEVSKNNAL------QLREKLGNIR--NQSDSE-EENIN 1479
Cdd:PTZ00440  1307 ------TKKAEEFSNDAKKE---LEKTDN-LIKQVEAKIEQAKEHKNKIYgsledkQIDDEIKKIEqiKEEISNkRKEIN 1376
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1480 LFIKKVK----NFLLEENVPPEDIEKVanGVLDIHLPIPSQNLTD-ELVKIQKHMQLCEDYRTDENRLNEEADGAQKLLV 1554
Cdd:PTZ00440  1377 KYLSNIKsnkeKCDLHVRNASRGKDKI--DFLNKHEAIEPSNSKEvNIIKITDNINKCKQYSNEAMETENKADENNDSII 1454
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462613137 1555 KAKAAEKA---ANILLNLDKTL-NQLQQAQITQGRANSTITQLTANITKIKKNVLQAENQTREMKSELELAKQRS 1625
Cdd:PTZ00440  1455 KYEKEITNilnNSSILGKKTKLeKKKKEATNIMDDINGEHSIIKTKLTKSSEKLNQLNEQPNIKREGDVLNNDKS 1529
cc_LAMB4_C cd22301
C-terminal coiled-coil domain found in laminin subunit beta-4 (LAMB4); LAMB4, also called ...
1690-1715 3.30e-04

C-terminal coiled-coil domain found in laminin subunit beta-4 (LAMB4); LAMB4, also called laminin beta-1-related protein, is a component of laminin, a complex glycoprotein consisting of three different polypeptide chains (alpha, beta, gamma). Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Mutations or loss of LAMB4 may be features of gastric and colorectal cancers. Reduced LAMB4 levels may contribute to colonic dysmotility associated with diverticulitis. This model corresponds to the C-terminal coiled-coil domain of LAMB4, which may be involved in the integrin binding activity.


Pssm-ID: 411972 [Multi-domain]  Cd Length: 70  Bit Score: 40.80  E-value: 3.30e-04
                           10        20
                   ....*....|....*....|....*.
gi 2462613137 1690 LGKVKQLKDAAEKLAGDTEAKIRRIT 1715
Cdd:cd22301      1 NERLKNIKKEAENLAKEIEDKMKRIE 26
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1420-1705 3.35e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.83  E-value: 3.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1420 QKAQEAKSIIRNLDKQVRGLKNQIESISEQAEvsknnalQLREKLGNIRNQSDSEEENINLFIKKVKNflLEENVPP--E 1497
Cdd:TIGR02169  702 NRLDELSQELSDASRKIGEIEKEIEQLEQEEE-------KLKERLEELEEDLSSLEQEIENVKSELKE--LEARIEEleE 772
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1498 DIEKVANGVLDIHlpipsQNLTDELVK-IQKHMQLCEDYRTD-ENRLNEeadgaqkllvkakaaekaanillnLDKTLNQ 1575
Cdd:TIGR02169  773 DLHKLEEALNDLE-----ARLSHSRIPeIQAELSKLEEEVSRiEARLRE------------------------IEQKLNR 823
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1576 LQQaqitqgranstitqltanitkiKKNVLQAENQTREMKSElELAKQRSGLEDGLSLLQTKLQRHQDHAVNAKVQAESA 1655
Cdd:TIGR02169  824 LTL----------------------EKEYLEKEIQELQEQRI-DLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDL 880
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462613137 1656 QHQAGSLEKEFVELKKQYAILQRKTSTTGLTKETLGK-VKQLKDAAEKLAG 1705
Cdd:TIGR02169  881 ESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKrLSELKAKLEALEE 931
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
265-323 4.40e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 39.64  E-value: 4.40e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462613137  265 CFCNGHAS---ECRPMQkmrgdvfsppgmvhGQCVCQHNTDGPNCERCKDFFQDAPWRPAAD 323
Cdd:pfam00053    1 CDCNPHGSlsdTCDPET--------------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQG 48
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1249-1583 5.42e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.51  E-value: 5.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1249 DSVRRQIMQLNEQLKAV-YEFQDLKDTIERAKNEADLLLEDLQE-EIDLQSSvlNASIADSSENIKKYYHISSSAEKKIN 1326
Cdd:COG4372     41 DKLQEELEQLREELEQArEELEQLEEELEQARSELEQLEEELEElNEQLQAA--QAELAQAQEELESLQEEAEELQEELE 118
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1327 ETSSTINTSANTRNDLLTILDTLTSKGNLSLERLKQIKIpDIQILNEKVcgdpgnvpcvplpcggalctgrkghrkcrgp 1406
Cdd:COG4372    119 ELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEE-QLESLQEEL------------------------------- 166
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1407 gchGSLTLSTNALQKAQeaksIIRNLDKQVRGLKNQIESISEQAEVSKNNALQLREKLGNIRNQSDSEEENINLFIKKVK 1486
Cdd:COG4372    167 ---AALEQELQALSEAE----AEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALL 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1487 NFLLEENVPPEDIEKVANGVLDIHLPIPSQNLTDELVKIqkhmqlcEDYRTDENRLNEEADGAQKLLVKAKAAEKAANIL 1566
Cdd:COG4372    240 DALELEEDKEELLEEVILKEIEELELAILVEKDTEEEEL-------EIAALELEALEEAALELKLLALLLNLAALSLIGA 312
                          330
                   ....*....|....*..
gi 2462613137 1567 LNLDKTLNQLQQAQITQ 1583
Cdd:COG4372    313 LEDALLAALLELAKKLE 329
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1462-1703 5.72e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.67  E-value: 5.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1462 EKLGNIRNQSDSEEENINLFIKKVKNF--LLEENvpPEDIEKVANGVLDIHLPIPSqnLTDELVKIQKHMQLCEDYRTDE 1539
Cdd:PRK03918   165 KNLGEVIKEIKRRIERLEKFIKRTENIeeLIKEK--EKELEEVLREINEISSELPE--LREELEKLEKEVKELEELKEEI 240
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1540 NRLNEEadgaqkllvkakaaekaaniLLNLDKTLNQLQqAQITQGRanSTITQLTANITKIKKNVLQAENQTREMKSELE 1619
Cdd:PRK03918   241 EELEKE--------------------LESLEGSKRKLE-EKIRELE--ERIEELKKEIEELEEKVKELKELKEKAEEYIK 297
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1620 LAKQRSGLEDGLSLLQTKLQR--HQDHAVNAKVQ-AESAQHQAGSLEKEFVELKKQYAILQRKTsttgltkETLGKVKQL 1696
Cdd:PRK03918   298 LSEFYEEYLDELREIEKRLSRleEEINGIEERIKeLEEKEERLEELKKKLKELEKRLEELEERH-------ELYEEAKAK 370

                   ....*..
gi 2462613137 1697 KDAAEKL 1703
Cdd:PRK03918   371 KEELERL 377
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1417-1705 6.66e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.67  E-value: 6.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1417 NALQKAQEaksIIRNLDKQVRGLKNQIESISEQAEVSKNNALQLREKLGNIRNQSDSEEEninlFIKKVKNflLEENVpp 1496
Cdd:PRK03918   162 NAYKNLGE---VIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPE----LREELEK--LEKEV-- 230
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1497 EDIEKVANGVldihlpipsQNLTDELVKIQKHMQ-LCEDYRTDENRLNEEADGAQKL-----LVKAKAAEKAANILLN-- 1568
Cdd:PRK03918   231 KELEELKEEI---------EELEKELESLEGSKRkLEEKIRELEERIEELKKEIEELeekvkELKELKEKAEEYIKLSef 301
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1569 LDKTLNQLQQAQITQGRanstitqLTANITKIKKNVLQAENQTREMKselELAKQRSGLEDGLSLLQTKLQRHQDhAVNA 1648
Cdd:PRK03918   302 YEEYLDELREIEKRLSR-------LEEEINGIEERIKELEEKEERLE---ELKKKLKELEKRLEELEERHELYEE-AKAK 370
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462613137 1649 KVQAES-----AQHQAGSLEKEFVELKKQYAILQRKTSTTGLTKETL-GKVKQLKDAAEKLAG 1705
Cdd:PRK03918   371 KEELERlkkrlTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELkKEIKELKKAIEELKK 433
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
1420-1703 7.67e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 43.36  E-value: 7.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1420 QKAQEAKSIIRNLDKQVRGLKNQIESISEQAEvsknnalQLREKLGNIRNQSDseeeninlfikkvknfllEENVPPEDI 1499
Cdd:COG1340     57 EEAQELREKRDELNEKVKELKEERDELNEKLN-------ELREELDELRKELA------------------ELNKAGGSI 111
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1500 EKvangvldihlpipsqnLTDELVKIQKhMQLCEDYRTDE--------NRLNEEADGAQKLLvkakaaekaaNILLNLDK 1571
Cdd:COG1340    112 DK----------------LRKEIERLEW-RQQTEVLSPEEekelvekiKELEKELEKAKKAL----------EKNEKLKE 164
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1572 TLNQLQQAQITQGRANSTITQLTANITKIKKNVLQAENQTREMKSELELAKQRsgledglslLQTKlqrhqdhavNAKVQ 1651
Cdd:COG1340    165 LRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADELRKEADELHKE---------IVEA---------QEKAD 226
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462613137 1652 AESAQHQAgsLEKEFVELKKQYAILQRKTSTTGLTKETLGKVKQLKDAAEKL 1703
Cdd:COG1340    227 ELHEEIIE--LQKELRELRKELKKLRKKQRALKREKEKEELEEKAEEIFEKL 276
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
291-313 8.13e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 38.83  E-value: 8.13e-04
                            10        20
                    ....*....|....*....|...
gi 2462613137   291 VHGQCVCQHNTDGPNCERCKDFF 313
Cdd:smart00180   16 DTGQCECKPNVTGRRCDRCAPGY 38
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1186-1703 1.45e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.51  E-value: 1.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1186 ISSLSKAVQGLMRLAANMEDKRETLPVCEADFKDLRGNVSEIERILKhpvfpsGKFLKVKDYHDSVRRqIMQLNEQLKAV 1265
Cdd:PRK03918   223 LEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIE------ELKKEIEELEEKVKE-LKELKEKAEEY 295
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1266 YEFQDLKDTIERAKNEADLLLEDLQEEIdlqsSVLNASIADSSENIKKYYHISSSaEKKINETSSTINTSANTRNDLLTI 1345
Cdd:PRK03918   296 IKLSEFYEEYLDELREIEKRLSRLEEEI----NGIEERIKELEEKEERLEELKKK-LKELEKRLEELEERHELYEEAKAK 370
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1346 LDTL----TSKGNLSLERLKQiKIPDIQILNEKVCGDPGNVpcvplpcggalcTGRKGHRKCRGpgchGSLTLSTNALQK 1421
Cdd:PRK03918   371 KEELerlkKRLTGLTPEKLEK-ELEELEKAKEEIEEEISKI------------TARIGELKKEI----KELKKAIEELKK 433
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1422 A-------------QEAKSIIRNLDKQVRGLKNQIESISEQAEvsknnalQLREKLGNIRNQSDSEEENINL-----FIK 1483
Cdd:PRK03918   434 AkgkcpvcgrelteEHRKELLEEYTAELKRIEKELKEIEEKER-------KLRKELRELEKVLKKESELIKLkelaeQLK 506
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1484 KVKNFLLEENVppEDIEKVANgvldihlpiPSQNLTDELVKIQKhmqlceDYRTDENRLNEEADGAQKLLVKAKAAEKAA 1563
Cdd:PRK03918   507 ELEEKLKKYNL--EELEKKAE---------EYEKLKEKLIKLKG------EIKSLKKELEKLEELKKKLAELEKKLDELE 569
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1564 NILLNLDKTLNQLQQAQITQgrANSTITQLtaniTKIKKNVLQAENQTREMKSELE-LAKQRSGLEDGLSLLQTKLQRhq 1642
Cdd:PRK03918   570 EELAELLKELEELGFESVEE--LEERLKEL----EPFYNEYLELKDAEKELEREEKeLKKLEEELDKAFEELAETEKR-- 641
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462613137 1643 dhavnakvqAESAQHQAGSLEKEFVElkKQYAILQRKtsTTGLTKETLGKVKQLKDAAEKL 1703
Cdd:PRK03918   642 ---------LEELRKELEELEKKYSE--EEYEELREE--YLELSRELAGLRAELEELEKRR 689
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1428-1713 2.81e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.62  E-value: 2.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1428 IIRNLDKQVRGLKNQiesiSEQAEvsknNALQLREKLgnirnqsdsEEENINLFIKKVKNFLLEEnvppEDIEKVAngvl 1507
Cdd:COG1196    194 ILGELERQLEPLERQ----AEKAE----RYRELKEEL---------KELEAELLLLKLRELEAEL----EELEAEL---- 248
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1508 dihlpipsQNLTDELVKIQKHMQLCE----DYRTDENRLNEEADGAQKLLvkAKAAEKAANILLNLDKTLNQLQQAQITQ 1583
Cdd:COG1196    249 --------EELEAELEELEAELAELEaeleELRLELEELELELEEAQAEE--YELLAELARLEQDIARLEERRRELEERL 318
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1584 GRANSTITQLTANITKIKKNVLQAENQTREMKSELE-LAKQRSGLEDGLSLLQTKLQRHQDHAVNAKVQAESAQHQAGSL 1662
Cdd:COG1196    319 EELEEELAELEEELEELEEELEELEEELEEAEEELEeAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAEL 398
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462613137 1663 EKEFVELKKQYAILQRKTSTtgLTKETLGKVKQLKDAAEKLAGDTEAKIRR 1713
Cdd:COG1196    399 AAQLEELEEAEEALLERLER--LEEELEELEEALAELEEEEEEEEEALEEA 447
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1432-1679 2.95e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.31  E-value: 2.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1432 LDKQVRGLKNQIESISEQAEV--SKNNALQLREKLG---NIRNQSDSEEENINLFIKKVK------NFLLE---ENVPPE 1497
Cdd:COG3206     69 LLSGLSSLSASDSPLETQIEIlkSRPVLERVVDKLNldeDPLGEEASREAAIERLRKNLTvepvkgSNVIEisyTSPDPE 148
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1498 DIEKVANGVLDIHLpipSQNL---TDELVKIQKHM--QLcEDYRTD----ENRLNE--------EADGAQKLLVkakaae 1560
Cdd:COG3206    149 LAAAVANALAEAYL---EQNLelrREEARKALEFLeeQL-PELRKEleeaEAALEEfrqknglvDLSEEAKLLL------ 218
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1561 kaaNILLNLDKTLNQLQ-QAQITQGRANSTITQLTAN---ITKIKKNVLQAENQTREMKSELELAKQRS----------G 1626
Cdd:COG3206    219 ---QQLSELESQLAEARaELAEAEARLAALRAQLGSGpdaLPELLQSPVIQQLRAQLAELEAELAELSArytpnhpdviA 295
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462613137 1627 LEDGLSLLQTKL-QRHQDHAVNAKVQAESAQHQAGSLEKEFVELKKQYAILQRK 1679
Cdd:COG3206    296 LRAQIAALRAQLqQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPEL 349
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1420-1687 9.00e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 9.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1420 QKAQEAKSIIRNLDKQVRGLKNQIESISEQAEVSKNNALQLREKLGNIRNQSDSEEENINlfikkvknflleenvppedi 1499
Cdd:COG4942     27 AELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELA-------------------- 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1500 ekvangvldihlpipsqNLTDELVKIQKhmqlceDYRTDENRLNEEADGAQKLlvkakAAEKAANILLNLD--------- 1570
Cdd:COG4942     87 -----------------ELEKEIAELRA------ELEAQKEELAELLRALYRL-----GRQPPLALLLSPEdfldavrrl 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1571 KTLNQLQQAQITQgranstITQLTANITKIKKNVLQAENQTREMKSEL-ELAKQRSGLEDGLSLLQTKLQRHQDHAVNAK 1649
Cdd:COG4942    139 QYLKYLAPARREQ------AEELRADLAELAALRAELEAERAELEALLaELEEERAALEALKAERQKLLARLEKELAELA 212
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 2462613137 1650 VQAESAQHQAGSLEKEFVELKKQYAILQRKTSTTGLTK 1687
Cdd:COG4942    213 AELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAA 250
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1420-1678 9.51e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 40.77  E-value: 9.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1420 QKAQE-AKSII-----RNLDKQVRGLKNQIESISEQAEvsknnalQLREKLgnirnqSDSEeeninlfiKKVKNFlleen 1493
Cdd:COG3206    148 ELAAAvANALAeayleQNLELRREEARKALEFLEEQLP-------ELRKEL------EEAE--------AALEEF----- 201
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1494 vppedieKVANGVLDihLPIPSQNLTDELVKIQKhmQLcEDYRTDENRLNEEADGAQKLLVKAKAAEKAAN---ILLNLD 1570
Cdd:COG3206    202 -------RQKNGLVD--LSEEAKLLLQQLSELES--QL-AEARAELAEAEARLAALRAQLGSGPDALPELLqspVIQQLR 269
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1571 KTLNQLQQ--AQITQ--GRANSTITQLTANITKIKKNVLQAENQTR-EMKSELELAKQRsgledgLSLLQTKLQrhqdha 1645
Cdd:COG3206    270 AQLAELEAelAELSAryTPNHPDVIALRAQIAALRAQLQQEAQRILaSLEAELEALQAR------EASLQAQLA------ 337
                          250       260       270
                   ....*....|....*....|....*....|...
gi 2462613137 1646 vnakvQAESAQHQAGSLEKEFVELKKQYAILQR 1678
Cdd:COG3206    338 -----QLEARLAELPELEAELRRLEREVEVARE 365
ClyA-like cd21116
family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including ...
1416-1612 9.79e-03

family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including Bacillus cereus HblB, Aeromonas hydrophila AhlB, Bacillus thuringiensis Cry6Aa and similar proteins; This family belongs to the ClyA family of alpha-PFT bacterial toxins. PFTs form the major group of virulence factors in many pathogenic bacteria and in general are critical components of the molecular offensive and defensive machinery of cells in all kingdoms of life. Bacterial PFTs facilitate the takeover of host resources by puncturing holes in the membrane. PFTs can be classified as alpha-PFTs and beta-PFTs depending on the secondary structures of their membrane component. Alpha-PFTs use a ring of amphipathic helices while beta-PFTs use a beta-barrel to construct the pore. Members of this family include the toxins: Bacillus cereus hemolysin binding component B (HblB or HBL-B) of the diarrheal enterotoxin hemolysin BL, Aeromonas hydrophila hemolytic (Ahl) component B (AhlB) of the tripartite AhlABC toxin, Vibrio cholerae cytotoxin motility associated killing factor A (MakA) cytotoxin, Xenorhabdus nematophila alpha-xenorhabdolysin (XaxA), Bacillus thuringiensis crystal 6Aa (Cry6Aa) parasporal crystal (Cry) toxin, and Bacillus cereus non-hemolytic enterotoxin (Nhe) component A (NheA) of the non-hemolytic enterotoxin Nhe, which, despite its name, is hemolytic, among others. In solution, ClyA proteins have an elongated, almost entirely alpha-helical structure, except for a short hydrophobic beta-hairpin known as the beta-tongue. Pore formation by ClyA requires circular oligomerization of the toxin by a sequential mechanism. This, in turn, concentrates the amphipathic helices in the center of the ring-like structure, forming a helical barrel that inserts into the membrane by a wedge-like mechanism. Compared with ClyA, NheA is almost entirely alpha-helical with an enlarged "head" domain, and an enlarged beta-tongue; it has been proposed that NheA could even form beta-barrel pores. Alpha-PFTs with similar structures are increasingly being found in eukaryotes, in particular as components of the immune systems of animals. This family may be distantly related to Escherichia coli alpha-PFT hemolysin E (HlyE, also known as ClyA or SheA).


Pssm-ID: 439149 [Multi-domain]  Cd Length: 224  Bit Score: 39.70  E-value: 9.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1416 TNALQKAQEAKSIIR----NLDKQVRGLKNQIES----ISEQAEV----SKNNALQLREKLGNIRNQSDSEEENINLFIK 1483
Cdd:cd21116     40 ALARAHALEWLNEIKpkllSLPNDIIGYNNTFQSyypdLIELADNlikgDQGAKQQLLQGLEALQSQVTKKQTSVTSFIN 119
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462613137 1484 KVKNFLLeenvppediekvangvldiHLPIPSQNLTDELVKIQKHMQLCEDYRTDENRLNEEADGAQKLLVkakaaekaa 1563
Cdd:cd21116    120 ELTTFKN-------------------DLDDDSRNLQTDATKAQAQVAVLNALKNQLNSLAEQIDAAIDALE--------- 171
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462613137 1564 nillNLDKTLNQLQQ------AQITQGRANSTITQLTANITKIKKNVLQAENQTR 1612
Cdd:cd21116    172 ----KLSNDWQTLDSdikeliTDLEDAESSIDAAFLQADLKAAKADWNQLYEQAK 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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