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Conserved domains on  [gi|2462610155|ref|XP_054212197|]
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zinc finger and SCAN domain-containing protein 31 isoform X1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein; zinc finger and BTB domain-containing protein( domain architecture ID 12210801)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation| zinc finger and BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein may be involved in transcriptional regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
35-146 3.98e-63

leucine rich region;


:

Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 198.30  E-value: 3.98e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155   35 QEASRQLFRQFCYQETPGPREALSRLRELCHQWLRPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVV 114
Cdd:smart00431   1 PEIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLL 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462610155  115 EDLEQELSEPGNQAPDHEHGHsEVLLEDVEHL 146
Cdd:smart00431  81 EDLERELDEPGQQVSAHVHGQ-EVLLEKMVPL 111
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
238-397 8.86e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 8.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155 238 RHRCNECGKSFTKSSVLIEHQR--IHTGE--KPYECEE--CGKAFSRRSSLNEHRRSHTGEKPYQCKEC-------GKAF 304
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLN 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155 305 SASNGLTRHRRIHTGEKPYECKV--CGKAFLLSSCLVQHQRIHTGEKRYQCR--ECGKAFIQNAGLFQHLRVHTgEKPYQ 380
Cdd:COG5048   369 NEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT-NHAPL 447

                         170
                  ....*....|....*..
gi 2462610155 381 CSQCSKLFSKRTLLKKH 397
Cdd:COG5048   448 LCSILKSFRRDLDLSNH 464
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
176-285 8.71e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 8.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155 176 EQDGESIPENQELASKQEILKEMehlgdsrlQRDVSLDSKYRETCKRDSKAEKQQAHSTGERRH--RCNECGKSFTKSSV 253
Cdd:COG5048   362 KFSPLLNNEPPQSLQQYKDLKND--------KKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYN 433

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462610155 254 LIEHQRIHTGEKPYECEECGKaFSRRSSLNEH 285
Cdd:COG5048   434 LIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
 
Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
35-146 3.98e-63

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 198.30  E-value: 3.98e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155   35 QEASRQLFRQFCYQETPGPREALSRLRELCHQWLRPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVV 114
Cdd:smart00431   1 PEIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLL 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462610155  115 EDLEQELSEPGNQAPDHEHGHsEVLLEDVEHL 146
Cdd:smart00431  81 EDLERELDEPGQQVSAHVHGQ-EVLLEKMVPL 111
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 35-123 7.82e-53

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 170.75  E-value: 7.82e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155  35 QEASRQLFRQFCYQETPGPREALSRLRELCHQWLRPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVV 114
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80


                  ....*....
gi 2462610155 115 EDLEQELSE 123
Cdd:pfam02023  81 EDLLLERGE 89
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 36-119 2.00e-42

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 143.55  E-value: 2.00e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155  36 EASRQLFRQFCYQETPGPREALSRLRELCHQWLRPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVVE 115
Cdd:cd07936     2 ETYRQRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILELLVLEQFLIILPPEVQAWVRERKPESGEEAATLAE 81


                  ....
gi 2462610155 116 DLEQ 119
Cdd:cd07936    82 DLLA 85
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
238-397 8.86e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 8.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155 238 RHRCNECGKSFTKSSVLIEHQR--IHTGE--KPYECEE--CGKAFSRRSSLNEHRRSHTGEKPYQCKEC-------GKAF 304
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLN 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155 305 SASNGLTRHRRIHTGEKPYECKV--CGKAFLLSSCLVQHQRIHTGEKRYQCR--ECGKAFIQNAGLFQHLRVHTgEKPYQ 380
Cdd:COG5048   369 NEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT-NHAPL 447

                         170
                  ....*....|....*..
gi 2462610155 381 CSQCSKLFSKRTLLKKH 397
Cdd:COG5048   448 LCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
310-332 4.38e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 4.38e-05
                          10        20
                  ....*....|....*....|...
gi 2462610155 310 LTRHRRIHTGEKPYECKVCGKAF 332
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
mukB PRK04863
chromosome partition protein MukB;
54-208 1.64e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 40.71  E-value: 1.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155   54 REALSRLRELCH-----QWLRPEIHTKEQILEL-----LVLEQFLTILPEELQAwvREHHPESGEEAVAVVEDLEQELSE 123
Cdd:PRK04863   499 RELLRRLREQRHlaeqlQQLRMRLSELEQRLRQqqraeRLLAEFCKRLGKNLDD--EDELEQLQEELEARLESLSESVSE 576

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155  124 PGNQAPDHEHgHSEVLLEDVEHLKvKQEPTDIQLQPMVTQLRY---ESF--------CLHQFQEQDGESIPENQELAS-K 191
Cdd:PRK04863   577 ARERRMALRQ-QLEQLQARIQRLA-ARAPAWLAAQDALARLREqsgEEFedsqdvteYMQQLLERERELTVERDELAArK 654

                          170       180
                   ....*....|....*....|...
gi 2462610155  192 QEILKEMEHL------GDSRLQR 208
Cdd:PRK04863   655 QALDEEIERLsqpggsEDPRLNA 677
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
176-285 8.71e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 8.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155 176 EQDGESIPENQELASKQEILKEMehlgdsrlQRDVSLDSKYRETCKRDSKAEKQQAHSTGERRH--RCNECGKSFTKSSV 253
Cdd:COG5048   362 KFSPLLNNEPPQSLQQYKDLKND--------KKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYN 433

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462610155 254 LIEHQRIHTGEKPYECEECGKaFSRRSSLNEH 285
Cdd:COG5048   434 LIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
 
Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
35-146 3.98e-63

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 198.30  E-value: 3.98e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155   35 QEASRQLFRQFCYQETPGPREALSRLRELCHQWLRPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVV 114
Cdd:smart00431   1 PEIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLL 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462610155  115 EDLEQELSEPGNQAPDHEHGHsEVLLEDVEHL 146
Cdd:smart00431  81 EDLERELDEPGQQVSAHVHGQ-EVLLEKMVPL 111
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 35-123 7.82e-53

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 170.75  E-value: 7.82e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155  35 QEASRQLFRQFCYQETPGPREALSRLRELCHQWLRPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVV 114
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80


                  ....*....
gi 2462610155 115 EDLEQELSE 123
Cdd:pfam02023  81 EDLLLERGE 89
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 36-119 2.00e-42

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 143.55  E-value: 2.00e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155  36 EASRQLFRQFCYQETPGPREALSRLRELCHQWLRPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVVE 115
Cdd:cd07936     2 ETYRQRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILELLVLEQFLIILPPEVQAWVRERKPESGEEAATLAE 81


                  ....
gi 2462610155 116 DLEQ 119
Cdd:cd07936    82 DLLA 85
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
238-397 8.86e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 8.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155 238 RHRCNECGKSFTKSSVLIEHQR--IHTGE--KPYECEE--CGKAFSRRSSLNEHRRSHTGEKPYQCKEC-------GKAF 304
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLN 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155 305 SASNGLTRHRRIHTGEKPYECKV--CGKAFLLSSCLVQHQRIHTGEKRYQCR--ECGKAFIQNAGLFQHLRVHTgEKPYQ 380
Cdd:COG5048   369 NEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT-NHAPL 447

                         170
                  ....*....|....*..
gi 2462610155 381 CSQCSKLFSKRTLLKKH 397
Cdd:COG5048   448 LCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
220-406 1.14e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155 220 CKRDSKAEKQQAHSTGERRHRCNECGKSFTKSSVLIEHQRIHTGE-------KPYECEECGKAFSRRSSLNEHRRS--HT 290
Cdd:COG5048   236 SPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHS 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155 291 GE--KPYQCKE--CGKAFSASNGLTRHRRIHTGEKPYECK--VCGKAF--LLSSCLVQHQRIHTGEKRYQCRE-----CG 357
Cdd:COG5048   316 GEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFspLLNNEPPQSLQQYKDLKNDKKSEtlsnsCI 395

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462610155 358 KAFIQNAGLFQHLRVHTGEKPYQC--SQCSKLFSKRTLLKKHQKIHTGERP 406
Cdd:COG5048   396 RNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-325 2.24e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 2.24e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462610155 265 KPYECEECGKAFSRRSSLNEHRRSHTGEKPYQCKECGKAFSASNG--LTRHRRIHTGEKPYEC 325
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLN 94
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
207-294 2.67e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 2.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155 207 QRDVSLDSKYRETCKRDSKAEKQQahstgERRHRCNECGKSFTKSSVLIEHQRIHTGEKPYEC--EECGKAFSRRSSLNE 284
Cdd:COG5048     7 QSSSSNNSVLSSTPKSTLKSLSNA-----PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSR 81

                          90
                  ....*....|
gi 2462610155 285 HRRSHTGEKP 294
Cdd:COG5048    82 HLRTHHNNPS 91
zf-H2C2_2 pfam13465
Zinc-finger double domain;
310-332 4.38e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 4.38e-05
                          10        20
                  ....*....|....*....|...
gi 2462610155 310 LTRHRRIHTGEKPYECKVCGKAF 332
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
254-278 4.55e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 4.55e-05
                          10        20
                  ....*....|....*....|....*
gi 2462610155 254 LIEHQRIHTGEKPYECEECGKAFSR 278
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-305 4.78e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 4.78e-05
                          10        20
                  ....*....|....*....|....*
gi 2462610155 281 SLNEHRRSHTGEKPYQCKECGKAFS 305
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
338-362 1.49e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.49e-04
                          10        20
                  ....*....|....*....|....*
gi 2462610155 338 LVQHQRIHTGEKRYQCRECGKAFIQ 362
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 263-314 2.25e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 2.25e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462610155 263 GEKPYECE--ECGKAFSRRSSLNEHRR---------------SHTG----EKPYQCKECGKAFSASNGLTRHR 314
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspeKMNIfsakDKPYRCEVCDKRYKNLNGLKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
293-346 2.49e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 2.49e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462610155 293 KPYQCKECGKAFSASNGLTRHRRIHTGEKPYECKV--CGKAFLLSSCLVQHQRIHT 346
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHH 87
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 267-289 5.71e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 5.71e-04
                          10        20
                  ....*....|....*....|...
gi 2462610155 267 YECEECGKAFSRRSSLNEHRRSH 289
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
366-390 8.80e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.80e-04
                          10        20
                  ....*....|....*....|....*
gi 2462610155 366 LFQHLRVHTGEKPYQCSQCSKLFSK 390
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
mukB PRK04863
chromosome partition protein MukB;
54-208 1.64e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 40.71  E-value: 1.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155   54 REALSRLRELCH-----QWLRPEIHTKEQILEL-----LVLEQFLTILPEELQAwvREHHPESGEEAVAVVEDLEQELSE 123
Cdd:PRK04863   499 RELLRRLREQRHlaeqlQQLRMRLSELEQRLRQqqraeRLLAEFCKRLGKNLDD--EDELEQLQEELEARLESLSESVSE 576

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155  124 PGNQAPDHEHgHSEVLLEDVEHLKvKQEPTDIQLQPMVTQLRY---ESF--------CLHQFQEQDGESIPENQELAS-K 191
Cdd:PRK04863   577 ARERRMALRQ-QLEQLQARIQRLA-ARAPAWLAAQDALARLREqsgEEFedsqdvteYMQQLLERERELTVERDELAArK 654

                          170       180
                   ....*....|....*....|...
gi 2462610155  192 QEILKEMEHL------GDSRLQR 208
Cdd:PRK04863   655 QALDEEIERLsqpggsEDPRLNA 677
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 291-374 2.03e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155 291 GEKPYQCK--ECGKAFSASNGLTRHRRI-HTGEKPYEckvcgkafllSSCLVQHQRIHTGEKRYQCRECGKAFIQNAGLF 367
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHE----------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 2462610155 368 QHlRVHT 374
Cdd:COG5189   416 YH-RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 295-317 4.84e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 4.84e-03
                          10        20
                  ....*....|....*....|...
gi 2462610155 295 YQCKECGKAFSASNGLTRHRRIH 317
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 239-261 4.99e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 4.99e-03
                          10        20
                  ....*....|....*....|...
gi 2462610155 239 HRCNECGKSFTKSSVLIEHQRIH 261
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
176-285 8.71e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 8.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462610155 176 EQDGESIPENQELASKQEILKEMehlgdsrlQRDVSLDSKYRETCKRDSKAEKQQAHSTGERRH--RCNECGKSFTKSSV 253
Cdd:COG5048   362 KFSPLLNNEPPQSLQQYKDLKND--------KKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYN 433

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462610155 254 LIEHQRIHTGEKPYECEECGKaFSRRSSLNEH 285
Cdd:COG5048   434 LIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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