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Conserved domains on  [gi|2462605206|ref|XP_054209860|]
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synphilin-1 isoform X9 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SNCAIP_SNCA_bd super family cl25051
Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is ...
 152-195 4.25e-14

Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is responsible for binding to alpha-Synuclein.


The actual alignment was detected with superfamily member pfam16700:

Pssm-ID: 435527  Cd Length: 45  Bit Score: 66.68  E-value: 4.25e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2462605206 152 VETCMSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGK 195
Cdd:pfam16700   1 VETCMSLASQVVKLTKQLHEQTAARIAIQKHLQLLFDPQDAEGR 44
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-149 2.39e-12

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.06  E-value: 2.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462605206  34 QNGQLECVRWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGC 112
Cdd:COG0666   129 YNGNLEIVKLLL---EAGADVnAQDNDGNTPLHLAAANGNLEIVKLLL----EAGADVNARDNDGETPLHLAAENGHLEI 201

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462605206 113 IQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYL 149
Cdd:COG0666   202 VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLL 238
 
Name Accession Description Interval E-value
SNCAIP_SNCA_bd pfam16700
Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is ...
 152-195 4.25e-14

Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is responsible for binding to alpha-Synuclein.


Pssm-ID: 435527  Cd Length: 45  Bit Score: 66.68  E-value: 4.25e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2462605206 152 VETCMSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGK 195
Cdd:pfam16700   1 VETCMSLASQVVKLTKQLHEQTAARIAIQKHLQLLFDPQDAEGR 44
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-149 2.39e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.06  E-value: 2.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462605206  34 QNGQLECVRWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGC 112
Cdd:COG0666   129 YNGNLEIVKLLL---EAGADVnAQDNDGNTPLHLAAANGNLEIVKLLL----EAGADVNARDNDGETPLHLAAENGHLEI 201

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462605206 113 IQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYL 149
Cdd:COG0666   202 VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLL 238
Ank_2 pfam12796
Ankyrin repeats (3 copies);
34-127 1.43e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.12  E-value: 1.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462605206  34 QNGQLECVRWMVSETEAIAELSCSKDFPslIHYAGCYGQEKILLWLLQFMQeqgisLDEVDqDGNSAVHVASQHGYLGCI 113
Cdd:pfam12796   6 KNGNLELVKLLLENGADANLQDKNGRTA--LHLAAKNGHLEIVKLLLEHAD-----VNLKD-NGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 2462605206 114 QTLVEYGANVTMQN 127
Cdd:pfam12796  78 KLLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 62-150 1.98e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.18  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462605206  62 SLIHYAGCYGQEKILLWLLQFMQEQGISldevDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQG 141
Cdd:PHA02874  126 TFLHYAIKKGDLESIKMLFEYGADVNIE----DDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYG 201


                  ....*....
gi 2462605206 142 HTLCSRYLV 150
Cdd:PHA02874  202 DYACIKLLI 210
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 96-125 1.02e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 1.02e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462605206   96 DGNSAVHVASQHGYLGCIQTLVEYGANVTM 125
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
SNCAIP_SNCA_bd pfam16700
Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is ...
 152-195 4.25e-14

Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is responsible for binding to alpha-Synuclein.


Pssm-ID: 435527  Cd Length: 45  Bit Score: 66.68  E-value: 4.25e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2462605206 152 VETCMSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGK 195
Cdd:pfam16700   1 VETCMSLASQVVKLTKQLHEQTAARIAIQKHLQLLFDPQDAEGR 44
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-149 2.39e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.06  E-value: 2.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462605206  34 QNGQLECVRWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGC 112
Cdd:COG0666   129 YNGNLEIVKLLL---EAGADVnAQDNDGNTPLHLAAANGNLEIVKLLL----EAGADVNARDNDGETPLHLAAENGHLEI 201

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462605206 113 IQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYL 149
Cdd:COG0666   202 VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLL 238
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-150 1.81e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 65.36  E-value: 1.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462605206  34 QNGQLECVRWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGC 112
Cdd:COG0666    96 RNGDLEIVKLLL---EAGADVnARDKDGETPLHLAAYNGNLEIVKLLL----EAGADVNAQDNDGNTPLHLAAANGNLEI 168

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2462605206 113 IQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 150
Cdd:COG0666   169 VKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLL 206
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
58-150 3.68e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.51  E-value: 3.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462605206  58 KDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSA 137
Cdd:COG0666    85 DGGNTLLHAAARNGDLEIVKLLL----EAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                          90
                  ....*....|...
gi 2462605206 138 ERQGHTLCSRYLV 150
Cdd:COG0666   161 AANGNLEIVKLLL 173
Ank_2 pfam12796
Ankyrin repeats (3 copies);
34-127 1.43e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.12  E-value: 1.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462605206  34 QNGQLECVRWMVSETEAIAELSCSKDFPslIHYAGCYGQEKILLWLLQFMQeqgisLDEVDqDGNSAVHVASQHGYLGCI 113
Cdd:pfam12796   6 KNGNLELVKLLLENGADANLQDKNGRTA--LHLAAKNGHLEIVKLLLEHAD-----VNLKD-NGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 2462605206 114 QTLVEYGANVTMQN 127
Cdd:pfam12796  78 KLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
64-150 1.76e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 49.34  E-value: 1.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462605206  64 IHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYgANVTMQNHaGEKPSQSAERQGHT 143
Cdd:pfam12796   1 LHLAAKNGNLELVKLLL----ENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHL 74


                  ....*..
gi 2462605206 144 LCSRYLV 150
Cdd:pfam12796  75 EIVKLLL 81
Ank_4 pfam13637
Ankyrin repeats (many copies);
62-117 5.63e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 5.63e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462605206  62 SLIHYAGCYGQEKILLWLLQFmqeqGISLDEVDQDGNSAVHVASQHGYLGCIQTLV 117
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEK----GADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-149 2.37e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 46.49  E-value: 2.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462605206  34 QNGQLECVRWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGC 112
Cdd:COG0666   162 ANGNLEIVKLLL---EAGADVnARDNDGETPLHLAAENGHLEIVKLLL----EAGADVNAKDNDGKTALDLAAENGNLEI 234

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2462605206 113 IQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYL 149
Cdd:COG0666   235 VKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
Ank_4 pfam13637
Ankyrin repeats (many copies);
97-150 7.91e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 7.91e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462605206  97 GNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 150
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 62-150 1.98e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.18  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462605206  62 SLIHYAGCYGQEKILLWLLQFMQEQGISldevDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQG 141
Cdd:PHA02874  126 TFLHYAIKKGDLESIKMLFEYGADVNIE----DDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYG 201


                  ....*....
gi 2462605206 142 HTLCSRYLV 150
Cdd:PHA02874  202 DYACIKLLI 210
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
50-150 2.16e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 43.40  E-value: 2.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462605206  50 AIAELSCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHA 129
Cdd:COG0666    44 LLALALADALGALLLLAAALAGDLLVALLLL----AAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKD 119

                          90       100
                  ....*....|....*....|.
gi 2462605206 130 GEKPSQSAERQGHTLCSRYLV 150
Cdd:COG0666   120 GETPLHLAAYNGNLEIVKLLL 140
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 85-141 5.02e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.96  E-value: 5.02e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462605206  85 EQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQG 141
Cdd:PTZ00322  103 TGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENG 159
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 96-125 1.02e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 1.02e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462605206   96 DGNSAVHVASQHGYLGCIQTLVEYGANVTM 125
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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