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Conserved domains on  [gi|2462598530|ref|XP_054206637|]
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rap1 GTPase-GDP dissociation stimulator 1 isoform X3 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 11997863)

armadillo/beta-catenin-like repeat-containing protein similar to catenin delta and plakophilin

CATH:  1.25.10.10
Gene Ontology:  GO:0098609|GO:0005515
PubMed:  12946625|9770300|9298899|20688255
SCOP:  3000116

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 86-117 9.73e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.75  E-value: 9.73e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2462598530  86 VDAGLISPLVQLLNSKDQEVLLQTGRALGNIC 117
Cdd:pfam00514   9 IEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 297-340 9.42e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 9.42e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462598530  297 NDANCIHMVDNGIVEKLMDLLDrhveDGNVTVQHAALSALRNLA 340
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLS 40
PLN03200 super family cl33659
cellulose synthase-interactive protein; Provisional
 30-215 6.25e-03

cellulose synthase-interactive protein; Provisional


The actual alignment was detected with superfamily member PLN03200:

Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 39.70  E-value: 6.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598530   30 LLQALAQNNTETSEKIQASGILQLFASLLTPQS--SCKAKVANII-AEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVL 106
Cdd:PLN03200   212 LLARLMMAFESSISKVLDAGAVKQLLKLLGQGNevSVRAEAAGALeALSSQSKEAKQAIADAGGIPALINATVAPSKEFM 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598530  107 L-QTGRALgnicyDSHSLQAqLINM-GVIPTLVKLLGIHCQNAALTEMCLVAFGNLA-------ELESSKEQFASTNIAE 177
Cdd:PLN03200   292 QgEFAQAL-----QENAMGA-LANIcGGMSALILYLGELSESPRSPAPIADTLGALAyalmvfdSSAESTRAFDPTVIEQ 365

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2462598530  178 ELVKLFKKQIEHDKREMIFEVLAPLAEND--AIKLQLVEA 215
Cdd:PLN03200   366 ILVKLLKPRDTKLVQERIIEALASLYGNAylSRKLNHAEA 405
 
Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 86-117 9.73e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.75  E-value: 9.73e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2462598530  86 VDAGLISPLVQLLNSKDQEVLLQTGRALGNIC 117
Cdd:pfam00514   9 IEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 78-118 2.24e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.95  E-value: 2.24e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462598530   78 NEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICY 118
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 297-340 9.42e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 9.42e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462598530  297 NDANCIHMVDNGIVEKLMDLLDrhveDGNVTVQHAALSALRNLA 340
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLS 40
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
86-140 3.62e-03

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 40.26  E-value: 3.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462598530  86 VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLL 140
Cdd:COG5064   154 VDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLL 208
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 297-340 4.52e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.12  E-value: 4.52e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2462598530 297 NDANCIHMVDNGIVEKLMDLLDrhveDGNVTVQHAALSALRNLA 340
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLS----SPDEEVQEEAAWALSNLA 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 30-215 6.25e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 39.70  E-value: 6.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598530   30 LLQALAQNNTETSEKIQASGILQLFASLLTPQS--SCKAKVANII-AEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVL 106
Cdd:PLN03200   212 LLARLMMAFESSISKVLDAGAVKQLLKLLGQGNevSVRAEAAGALeALSSQSKEAKQAIADAGGIPALINATVAPSKEFM 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598530  107 L-QTGRALgnicyDSHSLQAqLINM-GVIPTLVKLLGIHCQNAALTEMCLVAFGNLA-------ELESSKEQFASTNIAE 177
Cdd:PLN03200   292 QgEFAQAL-----QENAMGA-LANIcGGMSALILYLGELSESPRSPAPIADTLGALAyalmvfdSSAESTRAFDPTVIEQ 365

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2462598530  178 ELVKLFKKQIEHDKREMIFEVLAPLAEND--AIKLQLVEA 215
Cdd:PLN03200   366 ILVKLLKPRDTKLVQERIIEALASLYGNAylSRKLNHAEA 405
 
Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 86-117 9.73e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.75  E-value: 9.73e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2462598530  86 VDAGLISPLVQLLNSKDQEVLLQTGRALGNIC 117
Cdd:pfam00514   9 IEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 78-118 2.24e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.95  E-value: 2.24e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462598530   78 NEFMRIPCVDAGLISPLVQLLNSKDQEVLLQTGRALGNICY 118
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 297-340 9.42e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 9.42e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2462598530  297 NDANCIHMVDNGIVEKLMDLLDrhveDGNVTVQHAALSALRNLA 340
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLS 40
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
86-140 3.62e-03

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 40.26  E-value: 3.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462598530  86 VDAGLISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLL 140
Cdd:COG5064   154 VDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLL 208
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 297-340 4.52e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.12  E-value: 4.52e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2462598530 297 NDANCIHMVDNGIVEKLMDLLDrhveDGNVTVQHAALSALRNLA 340
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLS----SPDEEVQEEAAWALSNLA 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 30-215 6.25e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 39.70  E-value: 6.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598530   30 LLQALAQNNTETSEKIQASGILQLFASLLTPQS--SCKAKVANII-AEVAKNEFMRIPCVDAGLISPLVQLLNSKDQEVL 106
Cdd:PLN03200   212 LLARLMMAFESSISKVLDAGAVKQLLKLLGQGNevSVRAEAAGALeALSSQSKEAKQAIADAGGIPALINATVAPSKEFM 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462598530  107 L-QTGRALgnicyDSHSLQAqLINM-GVIPTLVKLLGIHCQNAALTEMCLVAFGNLA-------ELESSKEQFASTNIAE 177
Cdd:PLN03200   292 QgEFAQAL-----QENAMGA-LANIcGGMSALILYLGELSESPRSPAPIADTLGALAyalmvfdSSAESTRAFDPTVIEQ 365

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 2462598530  178 ELVKLFKKQIEHDKREMIFEVLAPLAEND--AIKLQLVEA 215
Cdd:PLN03200   366 ILVKLLKPRDTKLVQERIIEALASLYGNAylSRKLNHAEA 405
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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