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Conserved domains on  [gi|2462595972|ref|XP_054205408|]
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transmembrane protein 131-like isoform X18 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TMEM131_like pfam19532
Transmembrane protein 131-like; Transmembrane protein 131-like (TMEM131L) was identified as a ...
185-1608 0e+00

Transmembrane protein 131-like; Transmembrane protein 131-like (TMEM131L) was identified as a negative regulator of thymocyte proliferation that acts through mixed Wnt-dependent and independent mechanisms. It has two isoforms, L and S, which have different subcellular localization. L isoform, the membrane-associated form, inhibits canonical Wnt/beta-catenin signalling through the induction of lysosome-dependent degradation of the active phosphorylated form of the LRP6 coreceptor. This protein contains three conserved homology domains (CHD1, 2 and 3), a transmembrane region and a C-terminal serine-rich region. This family is related to pfam12371.


:

Pssm-ID: 437364  Cd Length: 1429  Bit Score: 2611.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  185 SGIGTRRISTEGSAKQLPNAYFLLPKVQSIQLSQMQAETTNTSLLQVQLECSLHNKVCQQLKGCYLESDDVLRLQMSIMV 264
Cdd:pfam19532    1 FGVGVPRVSTEGSKKQLPNAYLLLPHIQNIQLSQSQAETTNTSLLQVSLECSLPNKVCQQLKSCCLLSDDPLLLQMSISV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  265 TMENFSKEFEENTQHLLDHLSIVYVATDESETSDDSAVNMYILHSGNSLIWIQDIRHFSQRDALSLQFEPVLLPTSTTNF 344
Cdd:pfam19532   81 RMEESSKEFEELKQYLLENLFVVYVATDKTETSDDSIVNMYVLHSGNSLLWIQDVHHLSQRDTLSVEFEPVLLPTSTTNF 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  345 TKIASFTCKATSCDSGI--IEDVKKTTHTPTLKACLFSSVAQGYFRMDSSATQFHIETHENTSGLWSIWYRNHFDRSVVL 422
Cdd:pfam19532  161 TKVASIICKATSCDSGIsgDEEMNVVEGTAALKACLSHPVVEGYFRIDPSAAQFHIEPHQNASGFWSIWFTNNFEFSIVL 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  423 NDVFLSKETKHMLKILNFTGPLFLPPGCWNIFSLKLAVKDIAINLFTNVFLTTNIGAIFAIPLQIYSAPTKEGSLGFEVI 502
Cdd:pfam19532  241 NDVSVSKETKHLLKILNFTGPLTLPPGCWNIFSLKLAVKDTPLNLFTHVFLTTNLGVTFAIPLQIYSAPSKQGNLGFEVI 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  503 AHCGMHYFMGKSKAGNPNWNGSLSLDQSTWNVDSELANKLYERWKKYKNGDVCKRNVLGTTRFAHLKKSKESESFVFFLP 582
Cdd:pfam19532  321 AHCGVHCYLGKSKAVNPHWHRSLSLDRSTWDVDSELANELYERWQKIKSGEACRRNVLGMTRFAHEKKSKEFESFAFFLP 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  583 RLIAEPGLMLNFSATALRSRMVKYFVVQNPSSWPVSLQLLPLSLYPKPEALVHLLHRWFGTDTQMINFTTGEFQLTEACP 662
Cdd:pfam19532  401 RLITEPGLVLNFSATALRNSMVKYFVLKNPSSFPVTLQLLPLSHYPNPEAALSLLSKWFGTDVQAINVTTTEFRLTKECP 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  663 YLGTHSEE---SRFGILHLHLQPLEMKRVGVVFTPADYGKVTSLILIRNNLTVIDMIGVEGFGARELLKVGGRLPGAGGS 739
Cdd:pfam19532  481 HRGAHQEEdvkSSFGILHLHLQPLETRRIGVVFTPVDYGKVTSLILIRNNLTVLDMVTVEGFGARELLKVGGRLPGAGGS 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  740 LRFKVPESTLMDCRRQLKDSKQILSITKNFKVENIGPLPITVSSLKINGYNCQGYGFEVLDCHQFSLDPNTSRDISIVFT 819
Cdd:pfam19532  561 LRFKVPESTLMDCRRQLKDSKQILSITKNFKVENIGPLPITVSSMKINGYNCQGYGFEVLDCHSFSLDPNSSREISIVFT 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  820 PDFTSSWVIRDLSLVTAADLEFRFTLNVTLPHHLLPLCADVVPGPSWEESFWRLTVFFVSLSLLGVILIAFQQAQYILME 899
Cdd:pfam19532  641 PDFTSSWVIRELTLVTAAGLEFRFTLNVTLPHHLLPLCADVVPGPSWEESFWRLTVLFVSLSLLGVILIAFQQAQYILTE 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  900 FMKTRQRQNASSSSQQNNGPMDVISPHSYKSNCKNFLDTYGPSDKGRGKNCLPVNTPQSRIQNAAKRSPATYGHSQKKHK 979
Cdd:pfam19532  721 FMKSRQRPNPSSSLQQNSNSVDTISSDSYKGSCKTFLDSYSSSDKGKGKGCLSVNTPSSRSQNASKRSPATYGHSQKKHK 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  980 CSVYYSKHKTSTAAASSTSTTTEEKQtSPLGSSLPAAKEDICTDAMRENWISLRYASGINVNLQKNLTLPKNLLNKEENT 1059
Cdd:pfam19532  801 CSVYYSKQKLSTSSASSAGTTTEEKQ-QTSGSQTSAPKEDICTDIPSENWVTLRYANGISVNLQKNLTLPENFLGKEENA 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972 1060 LKNTIVFSNPSSECSMKEGIQTCMFPKETDIKTSENTAEFKERELCPLKTSKKLPENHLPRNSPQYhQPDLPEISRKNNG 1139
Cdd:pfam19532  880 LKNTVLVKNSSSECPLKEEPQTCMFPKETNLKTSENVAELKEQEFCPLKTSKKLPESHLPKNSPQQ-QSELQEISRKNNG 958
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972 1140 NNQQVPVKNEVDHCENLKKV-DTKPSSEKKIHKTSREDMFSEKQDIPFVEQEDPYRKKKLQEKREGNLQNLNWSKSRTCR 1218
Cdd:pfam19532  959 NNQQVPLKNEVENCETLKKQiDTKPSSEKKIHKTPKEDTCCEKQDIPSVEQEDPVRKKKPQEKREGNLQNLNWNKNRTCR 1038
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972 1219 KNKKRGVAPVSRPPEQSDLKLVCSDFERSELSSDINVRSWCIQEStREVCKADAEIAsSLPAAQREA-GYYQKPEKKCVD 1297
Cdd:pfam19532 1039 KNKKKGVASSPRGPEQSELKHLCSEFERSELRGDISLRNWCPQGN-GENCKAEPKTG-SLPLTEGETeSCYQNSKKKCGK 1116
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972 1298 KFCSDSSSDCGSSSGSVRASRGSWGSWSSTSSSDGDKKPMVDAQHFLPAGDSVSQNDFPSEAPISLNLSHNICNPMT-VN 1376
Cdd:pfam19532 1117 KFCSDSSSDCGSSSGSVRASRGSWGSWSSTSSSDGDKKPSIPARHFLPSRENQSQNDFPSEAPITLNLSHNICNPSRdVN 1196
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972 1377 SLPQYAEPSCPSLPAGPTGVEEDKGLYSPGDLWPTPPVCVTSSLNCTLENGVPCVIQESAPVHNSFIDWSATCEGQFSSA 1456
Cdd:pfam19532 1197 SLPQYPETLCPSFAAVAAGLKKNKGLYPPGDLWPSQPVCLTNGLNYNLENGMPCMIQEPPPVHNSFIDWNATCEGQFSNV 1276
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972 1457 YCPLELNDYNAFPEENMNYANGFPCPADVQTDFIDHNSQSTWNTPPNMPAAWGHASFISSPPYLTSTRSLSPMSGLFGSI 1536
Cdd:pfam19532 1277 YCPLELNDFNAFPEENMNYHNGFPCPEEQNTDFIDHSCQSTWNTPPDMPPTWEPASYVNSPPYLSSTRSLSPMSGLFGSI 1356
                         1370      1380      1390      1400      1410      1420      1430
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462595972 1537 WAPQSDVYENCCPINPTTEHSTHMENQAVVCK-EYYLGFNPFRAYMNLDIWTTTANRNANFPLSRDSSYCGNV 1608
Cdd:pfam19532 1357 WAPQSDVYESCCPVSPTTQHSAHNENQAVMCKqEYYPGFNPFRAYMNLDIWTSTANRNANFPLSRDSGYCGNV 1429
TMEM131_like_N super family cl48134
Transmembrane protein 131-like N-terminal; TMEM131_like is a family of bacterial, plant and ...
91-174 2.35e-17

Transmembrane protein 131-like N-terminal; TMEM131_like is a family of bacterial, plant and other metazoa transmembrane proteins. Many of the members are multi-pass transmembrane proteins. This domain represents the N-terminal region which contains a conserved homology domain (CHD1).


The actual alignment was detected with superfamily member pfam12371:

Pssm-ID: 463553  Cd Length: 84  Bit Score: 78.47  E-value: 2.35e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972   91 LHFQPSVLDFGIQFLGHPVAKILHAYNPSRDSEVVVNSVFAAAGHFHVPPVPCRVIPAMGKTSFRIIFLPTEEGSIESSL 170
Cdd:pfam12371    1 VSISPPVLDFGQQSLCVPASRVVTVVNMHQRETLFLLSVTTDSPDFYSSFFESVVLPPGGNTSFKVVFLPRELGASSASL 80

                   ....
gi 2462595972  171 FINT 174
Cdd:pfam12371   81 HLHT 84
 
Name Accession Description Interval E-value
TMEM131_like pfam19532
Transmembrane protein 131-like; Transmembrane protein 131-like (TMEM131L) was identified as a ...
185-1608 0e+00

Transmembrane protein 131-like; Transmembrane protein 131-like (TMEM131L) was identified as a negative regulator of thymocyte proliferation that acts through mixed Wnt-dependent and independent mechanisms. It has two isoforms, L and S, which have different subcellular localization. L isoform, the membrane-associated form, inhibits canonical Wnt/beta-catenin signalling through the induction of lysosome-dependent degradation of the active phosphorylated form of the LRP6 coreceptor. This protein contains three conserved homology domains (CHD1, 2 and 3), a transmembrane region and a C-terminal serine-rich region. This family is related to pfam12371.


Pssm-ID: 437364  Cd Length: 1429  Bit Score: 2611.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  185 SGIGTRRISTEGSAKQLPNAYFLLPKVQSIQLSQMQAETTNTSLLQVQLECSLHNKVCQQLKGCYLESDDVLRLQMSIMV 264
Cdd:pfam19532    1 FGVGVPRVSTEGSKKQLPNAYLLLPHIQNIQLSQSQAETTNTSLLQVSLECSLPNKVCQQLKSCCLLSDDPLLLQMSISV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  265 TMENFSKEFEENTQHLLDHLSIVYVATDESETSDDSAVNMYILHSGNSLIWIQDIRHFSQRDALSLQFEPVLLPTSTTNF 344
Cdd:pfam19532   81 RMEESSKEFEELKQYLLENLFVVYVATDKTETSDDSIVNMYVLHSGNSLLWIQDVHHLSQRDTLSVEFEPVLLPTSTTNF 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  345 TKIASFTCKATSCDSGI--IEDVKKTTHTPTLKACLFSSVAQGYFRMDSSATQFHIETHENTSGLWSIWYRNHFDRSVVL 422
Cdd:pfam19532  161 TKVASIICKATSCDSGIsgDEEMNVVEGTAALKACLSHPVVEGYFRIDPSAAQFHIEPHQNASGFWSIWFTNNFEFSIVL 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  423 NDVFLSKETKHMLKILNFTGPLFLPPGCWNIFSLKLAVKDIAINLFTNVFLTTNIGAIFAIPLQIYSAPTKEGSLGFEVI 502
Cdd:pfam19532  241 NDVSVSKETKHLLKILNFTGPLTLPPGCWNIFSLKLAVKDTPLNLFTHVFLTTNLGVTFAIPLQIYSAPSKQGNLGFEVI 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  503 AHCGMHYFMGKSKAGNPNWNGSLSLDQSTWNVDSELANKLYERWKKYKNGDVCKRNVLGTTRFAHLKKSKESESFVFFLP 582
Cdd:pfam19532  321 AHCGVHCYLGKSKAVNPHWHRSLSLDRSTWDVDSELANELYERWQKIKSGEACRRNVLGMTRFAHEKKSKEFESFAFFLP 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  583 RLIAEPGLMLNFSATALRSRMVKYFVVQNPSSWPVSLQLLPLSLYPKPEALVHLLHRWFGTDTQMINFTTGEFQLTEACP 662
Cdd:pfam19532  401 RLITEPGLVLNFSATALRNSMVKYFVLKNPSSFPVTLQLLPLSHYPNPEAALSLLSKWFGTDVQAINVTTTEFRLTKECP 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  663 YLGTHSEE---SRFGILHLHLQPLEMKRVGVVFTPADYGKVTSLILIRNNLTVIDMIGVEGFGARELLKVGGRLPGAGGS 739
Cdd:pfam19532  481 HRGAHQEEdvkSSFGILHLHLQPLETRRIGVVFTPVDYGKVTSLILIRNNLTVLDMVTVEGFGARELLKVGGRLPGAGGS 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  740 LRFKVPESTLMDCRRQLKDSKQILSITKNFKVENIGPLPITVSSLKINGYNCQGYGFEVLDCHQFSLDPNTSRDISIVFT 819
Cdd:pfam19532  561 LRFKVPESTLMDCRRQLKDSKQILSITKNFKVENIGPLPITVSSMKINGYNCQGYGFEVLDCHSFSLDPNSSREISIVFT 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  820 PDFTSSWVIRDLSLVTAADLEFRFTLNVTLPHHLLPLCADVVPGPSWEESFWRLTVFFVSLSLLGVILIAFQQAQYILME 899
Cdd:pfam19532  641 PDFTSSWVIRELTLVTAAGLEFRFTLNVTLPHHLLPLCADVVPGPSWEESFWRLTVLFVSLSLLGVILIAFQQAQYILTE 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  900 FMKTRQRQNASSSSQQNNGPMDVISPHSYKSNCKNFLDTYGPSDKGRGKNCLPVNTPQSRIQNAAKRSPATYGHSQKKHK 979
Cdd:pfam19532  721 FMKSRQRPNPSSSLQQNSNSVDTISSDSYKGSCKTFLDSYSSSDKGKGKGCLSVNTPSSRSQNASKRSPATYGHSQKKHK 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  980 CSVYYSKHKTSTAAASSTSTTTEEKQtSPLGSSLPAAKEDICTDAMRENWISLRYASGINVNLQKNLTLPKNLLNKEENT 1059
Cdd:pfam19532  801 CSVYYSKQKLSTSSASSAGTTTEEKQ-QTSGSQTSAPKEDICTDIPSENWVTLRYANGISVNLQKNLTLPENFLGKEENA 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972 1060 LKNTIVFSNPSSECSMKEGIQTCMFPKETDIKTSENTAEFKERELCPLKTSKKLPENHLPRNSPQYhQPDLPEISRKNNG 1139
Cdd:pfam19532  880 LKNTVLVKNSSSECPLKEEPQTCMFPKETNLKTSENVAELKEQEFCPLKTSKKLPESHLPKNSPQQ-QSELQEISRKNNG 958
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972 1140 NNQQVPVKNEVDHCENLKKV-DTKPSSEKKIHKTSREDMFSEKQDIPFVEQEDPYRKKKLQEKREGNLQNLNWSKSRTCR 1218
Cdd:pfam19532  959 NNQQVPLKNEVENCETLKKQiDTKPSSEKKIHKTPKEDTCCEKQDIPSVEQEDPVRKKKPQEKREGNLQNLNWNKNRTCR 1038
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972 1219 KNKKRGVAPVSRPPEQSDLKLVCSDFERSELSSDINVRSWCIQEStREVCKADAEIAsSLPAAQREA-GYYQKPEKKCVD 1297
Cdd:pfam19532 1039 KNKKKGVASSPRGPEQSELKHLCSEFERSELRGDISLRNWCPQGN-GENCKAEPKTG-SLPLTEGETeSCYQNSKKKCGK 1116
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972 1298 KFCSDSSSDCGSSSGSVRASRGSWGSWSSTSSSDGDKKPMVDAQHFLPAGDSVSQNDFPSEAPISLNLSHNICNPMT-VN 1376
Cdd:pfam19532 1117 KFCSDSSSDCGSSSGSVRASRGSWGSWSSTSSSDGDKKPSIPARHFLPSRENQSQNDFPSEAPITLNLSHNICNPSRdVN 1196
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972 1377 SLPQYAEPSCPSLPAGPTGVEEDKGLYSPGDLWPTPPVCVTSSLNCTLENGVPCVIQESAPVHNSFIDWSATCEGQFSSA 1456
Cdd:pfam19532 1197 SLPQYPETLCPSFAAVAAGLKKNKGLYPPGDLWPSQPVCLTNGLNYNLENGMPCMIQEPPPVHNSFIDWNATCEGQFSNV 1276
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972 1457 YCPLELNDYNAFPEENMNYANGFPCPADVQTDFIDHNSQSTWNTPPNMPAAWGHASFISSPPYLTSTRSLSPMSGLFGSI 1536
Cdd:pfam19532 1277 YCPLELNDFNAFPEENMNYHNGFPCPEEQNTDFIDHSCQSTWNTPPDMPPTWEPASYVNSPPYLSSTRSLSPMSGLFGSI 1356
                         1370      1380      1390      1400      1410      1420      1430
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462595972 1537 WAPQSDVYENCCPINPTTEHSTHMENQAVVCK-EYYLGFNPFRAYMNLDIWTTTANRNANFPLSRDSSYCGNV 1608
Cdd:pfam19532 1357 WAPQSDVYESCCPVSPTTQHSAHNENQAVMCKqEYYPGFNPFRAYMNLDIWTSTANRNANFPLSRDSGYCGNV 1429
TMEM131_like_N pfam12371
Transmembrane protein 131-like N-terminal; TMEM131_like is a family of bacterial, plant and ...
91-174 2.35e-17

Transmembrane protein 131-like N-terminal; TMEM131_like is a family of bacterial, plant and other metazoa transmembrane proteins. Many of the members are multi-pass transmembrane proteins. This domain represents the N-terminal region which contains a conserved homology domain (CHD1).


Pssm-ID: 463553  Cd Length: 84  Bit Score: 78.47  E-value: 2.35e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972   91 LHFQPSVLDFGIQFLGHPVAKILHAYNPSRDSEVVVNSVFAAAGHFHVPPVPCRVIPAMGKTSFRIIFLPTEEGSIESSL 170
Cdd:pfam12371    1 VSISPPVLDFGQQSLCVPASRVVTVVNMHQRETLFLLSVTTDSPDFYSSFFESVVLPPGGNTSFKVVFLPRELGASSASL 80

                   ....
gi 2462595972  171 FINT 174
Cdd:pfam12371   81 HLHT 84
 
Name Accession Description Interval E-value
TMEM131_like pfam19532
Transmembrane protein 131-like; Transmembrane protein 131-like (TMEM131L) was identified as a ...
185-1608 0e+00

Transmembrane protein 131-like; Transmembrane protein 131-like (TMEM131L) was identified as a negative regulator of thymocyte proliferation that acts through mixed Wnt-dependent and independent mechanisms. It has two isoforms, L and S, which have different subcellular localization. L isoform, the membrane-associated form, inhibits canonical Wnt/beta-catenin signalling through the induction of lysosome-dependent degradation of the active phosphorylated form of the LRP6 coreceptor. This protein contains three conserved homology domains (CHD1, 2 and 3), a transmembrane region and a C-terminal serine-rich region. This family is related to pfam12371.


Pssm-ID: 437364  Cd Length: 1429  Bit Score: 2611.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  185 SGIGTRRISTEGSAKQLPNAYFLLPKVQSIQLSQMQAETTNTSLLQVQLECSLHNKVCQQLKGCYLESDDVLRLQMSIMV 264
Cdd:pfam19532    1 FGVGVPRVSTEGSKKQLPNAYLLLPHIQNIQLSQSQAETTNTSLLQVSLECSLPNKVCQQLKSCCLLSDDPLLLQMSISV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  265 TMENFSKEFEENTQHLLDHLSIVYVATDESETSDDSAVNMYILHSGNSLIWIQDIRHFSQRDALSLQFEPVLLPTSTTNF 344
Cdd:pfam19532   81 RMEESSKEFEELKQYLLENLFVVYVATDKTETSDDSIVNMYVLHSGNSLLWIQDVHHLSQRDTLSVEFEPVLLPTSTTNF 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  345 TKIASFTCKATSCDSGI--IEDVKKTTHTPTLKACLFSSVAQGYFRMDSSATQFHIETHENTSGLWSIWYRNHFDRSVVL 422
Cdd:pfam19532  161 TKVASIICKATSCDSGIsgDEEMNVVEGTAALKACLSHPVVEGYFRIDPSAAQFHIEPHQNASGFWSIWFTNNFEFSIVL 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  423 NDVFLSKETKHMLKILNFTGPLFLPPGCWNIFSLKLAVKDIAINLFTNVFLTTNIGAIFAIPLQIYSAPTKEGSLGFEVI 502
Cdd:pfam19532  241 NDVSVSKETKHLLKILNFTGPLTLPPGCWNIFSLKLAVKDTPLNLFTHVFLTTNLGVTFAIPLQIYSAPSKQGNLGFEVI 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  503 AHCGMHYFMGKSKAGNPNWNGSLSLDQSTWNVDSELANKLYERWKKYKNGDVCKRNVLGTTRFAHLKKSKESESFVFFLP 582
Cdd:pfam19532  321 AHCGVHCYLGKSKAVNPHWHRSLSLDRSTWDVDSELANELYERWQKIKSGEACRRNVLGMTRFAHEKKSKEFESFAFFLP 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  583 RLIAEPGLMLNFSATALRSRMVKYFVVQNPSSWPVSLQLLPLSLYPKPEALVHLLHRWFGTDTQMINFTTGEFQLTEACP 662
Cdd:pfam19532  401 RLITEPGLVLNFSATALRNSMVKYFVLKNPSSFPVTLQLLPLSHYPNPEAALSLLSKWFGTDVQAINVTTTEFRLTKECP 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  663 YLGTHSEE---SRFGILHLHLQPLEMKRVGVVFTPADYGKVTSLILIRNNLTVIDMIGVEGFGARELLKVGGRLPGAGGS 739
Cdd:pfam19532  481 HRGAHQEEdvkSSFGILHLHLQPLETRRIGVVFTPVDYGKVTSLILIRNNLTVLDMVTVEGFGARELLKVGGRLPGAGGS 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  740 LRFKVPESTLMDCRRQLKDSKQILSITKNFKVENIGPLPITVSSLKINGYNCQGYGFEVLDCHQFSLDPNTSRDISIVFT 819
Cdd:pfam19532  561 LRFKVPESTLMDCRRQLKDSKQILSITKNFKVENIGPLPITVSSMKINGYNCQGYGFEVLDCHSFSLDPNSSREISIVFT 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  820 PDFTSSWVIRDLSLVTAADLEFRFTLNVTLPHHLLPLCADVVPGPSWEESFWRLTVFFVSLSLLGVILIAFQQAQYILME 899
Cdd:pfam19532  641 PDFTSSWVIRELTLVTAAGLEFRFTLNVTLPHHLLPLCADVVPGPSWEESFWRLTVLFVSLSLLGVILIAFQQAQYILTE 720
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  900 FMKTRQRQNASSSSQQNNGPMDVISPHSYKSNCKNFLDTYGPSDKGRGKNCLPVNTPQSRIQNAAKRSPATYGHSQKKHK 979
Cdd:pfam19532  721 FMKSRQRPNPSSSLQQNSNSVDTISSDSYKGSCKTFLDSYSSSDKGKGKGCLSVNTPSSRSQNASKRSPATYGHSQKKHK 800
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972  980 CSVYYSKHKTSTAAASSTSTTTEEKQtSPLGSSLPAAKEDICTDAMRENWISLRYASGINVNLQKNLTLPKNLLNKEENT 1059
Cdd:pfam19532  801 CSVYYSKQKLSTSSASSAGTTTEEKQ-QTSGSQTSAPKEDICTDIPSENWVTLRYANGISVNLQKNLTLPENFLGKEENA 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972 1060 LKNTIVFSNPSSECSMKEGIQTCMFPKETDIKTSENTAEFKERELCPLKTSKKLPENHLPRNSPQYhQPDLPEISRKNNG 1139
Cdd:pfam19532  880 LKNTVLVKNSSSECPLKEEPQTCMFPKETNLKTSENVAELKEQEFCPLKTSKKLPESHLPKNSPQQ-QSELQEISRKNNG 958
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972 1140 NNQQVPVKNEVDHCENLKKV-DTKPSSEKKIHKTSREDMFSEKQDIPFVEQEDPYRKKKLQEKREGNLQNLNWSKSRTCR 1218
Cdd:pfam19532  959 NNQQVPLKNEVENCETLKKQiDTKPSSEKKIHKTPKEDTCCEKQDIPSVEQEDPVRKKKPQEKREGNLQNLNWNKNRTCR 1038
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972 1219 KNKKRGVAPVSRPPEQSDLKLVCSDFERSELSSDINVRSWCIQEStREVCKADAEIAsSLPAAQREA-GYYQKPEKKCVD 1297
Cdd:pfam19532 1039 KNKKKGVASSPRGPEQSELKHLCSEFERSELRGDISLRNWCPQGN-GENCKAEPKTG-SLPLTEGETeSCYQNSKKKCGK 1116
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972 1298 KFCSDSSSDCGSSSGSVRASRGSWGSWSSTSSSDGDKKPMVDAQHFLPAGDSVSQNDFPSEAPISLNLSHNICNPMT-VN 1376
Cdd:pfam19532 1117 KFCSDSSSDCGSSSGSVRASRGSWGSWSSTSSSDGDKKPSIPARHFLPSRENQSQNDFPSEAPITLNLSHNICNPSRdVN 1196
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972 1377 SLPQYAEPSCPSLPAGPTGVEEDKGLYSPGDLWPTPPVCVTSSLNCTLENGVPCVIQESAPVHNSFIDWSATCEGQFSSA 1456
Cdd:pfam19532 1197 SLPQYPETLCPSFAAVAAGLKKNKGLYPPGDLWPSQPVCLTNGLNYNLENGMPCMIQEPPPVHNSFIDWNATCEGQFSNV 1276
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972 1457 YCPLELNDYNAFPEENMNYANGFPCPADVQTDFIDHNSQSTWNTPPNMPAAWGHASFISSPPYLTSTRSLSPMSGLFGSI 1536
Cdd:pfam19532 1277 YCPLELNDFNAFPEENMNYHNGFPCPEEQNTDFIDHSCQSTWNTPPDMPPTWEPASYVNSPPYLSSTRSLSPMSGLFGSI 1356
                         1370      1380      1390      1400      1410      1420      1430
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462595972 1537 WAPQSDVYENCCPINPTTEHSTHMENQAVVCK-EYYLGFNPFRAYMNLDIWTTTANRNANFPLSRDSSYCGNV 1608
Cdd:pfam19532 1357 WAPQSDVYESCCPVSPTTQHSAHNENQAVMCKqEYYPGFNPFRAYMNLDIWTSTANRNANFPLSRDSGYCGNV 1429
TMEM131_like_N pfam12371
Transmembrane protein 131-like N-terminal; TMEM131_like is a family of bacterial, plant and ...
91-174 2.35e-17

Transmembrane protein 131-like N-terminal; TMEM131_like is a family of bacterial, plant and other metazoa transmembrane proteins. Many of the members are multi-pass transmembrane proteins. This domain represents the N-terminal region which contains a conserved homology domain (CHD1).


Pssm-ID: 463553  Cd Length: 84  Bit Score: 78.47  E-value: 2.35e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972   91 LHFQPSVLDFGIQFLGHPVAKILHAYNPSRDSEVVVNSVFAAAGHFHVPPVPCRVIPAMGKTSFRIIFLPTEEGSIESSL 170
Cdd:pfam12371    1 VSISPPVLDFGQQSLCVPASRVVTVVNMHQRETLFLLSVTTDSPDFYSSFFESVVLPPGGNTSFKVVFLPRELGASSASL 80

                   ....
gi 2462595972  171 FINT 174
Cdd:pfam12371   81 HLHT 84
ASH pfam15780
Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin; The ASH domain or N-terminal ...
92-184 2.52e-03

Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin; The ASH domain or N-terminal domain of abnormal spindle-like microcephaly-associated protein are found in proteins associated with cilia, flagella, the centrosome and the Golgi complex. The domain is also found in Hydin and OCRL whose deficiencies are associated with hydrocephalus and Lowe oculocerebrorenal syndrome (OCRL), respectively. The fact that Human ASPM protein carries an ASH domain indicates possible roles for ASPM in sperm flagellar or in ependymal cells' cilia. The presence of ASH in centrosomal and ciliary proteins indicates that ASPM may possess roles not only in mitotic spindle regulation, but also in ciliary and flagellar function.


Pssm-ID: 464865 [Multi-domain]  Cd Length: 98  Bit Score: 38.80  E-value: 2.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462595972   92 HFQPSV-LDFGIQFLGHPVAKILHAYNPSRD-SEVVVNSVFAAAGHFHVPPvPCRVIPAMGKTSFRIIFLPTEEGSIESS 169
Cdd:pfam15780    7 PFSRQPfVCFGDVPVGTSAERLLTVVNPSEEpAEVKVSKVPAPTKGFSVSP-LEFTVQPGESQTLTVTWTPTEEGAVRET 85
                           90
                   ....*....|....*
gi 2462595972  170 LFINTSsyGVLSYHV 184
Cdd:pfam15780   86 LQFTVN--DVGKHQV 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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